Natural Product: NPC137493

Natural Product ID:  NPC137493
Common Name:   Aglaiabbreviatin D
IUPAC Name:   (5R,8R,9R,10R,13R,14R,17S)-4,4,8,10,14-pentamethyl-17-[(2S)-2,6,6-trimethyl-3H-pyran-2-yl]-1,2,5,6,7,9,11,12,13,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
Synonyms:   Aglaiabbreviatin D
Molecular Formula:   C30H48O2
Standard InCHIKey:  WVWUAJRNIVNQJF-MRULXVATSA-N
Standard InCHI:  InChI=1S/C30H48O2/c1-25(2)15-9-16-30(8,32-25)21-12-18-28(6)20(21)10-11-23-27(5)17-14-24(31)26(3,4)22(27)13-19-29(23,28)7/h9,15,20-23H,10-14,16-19H2,1-8H3/t20-,21+,22+,23-,27+,28-,29-,30+/m1/s1
Canonical SMILES:  O=C1CC[C@]2([C@H](C1(C)C)CC[C@@]1([C@@H]2CC[C@H]2[C@@]1(C)CC[C@@H]2[C@]1(C)CC=CC(O1)(C)C)C)C
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO7602 Aglaia abbreviata Species Meliaceae Eukaryota PMID[21087017]
NPO7602 Aglaia abbreviata Species Meliaceae Eukaryota Stems PMID[21087017]

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT83 Cell Line MCF7 Homo sapiens IC50 > 10000 nM 21087017
NPT2 Others Unspecified IC50 > 10000 nM 21087017
NPT91 Cell Line KB Homo sapiens IC50 = 1200 nM 21087017
NPT2 Others Unspecified IC50 = 960 nM 21087017
NPT659 Cell Line SMMC-7721 Homo sapiens IC50 = 2100 nM 21087017
NPT111 Cell Line K562 Homo sapiens IC50 = 1200 nM 21087017

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC137493 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
0.875 High Similarity NPC470557
0.8621 High Similarity NPC285982
0.8571 High Similarity NPC470046
0.8571 High Similarity NPC470047
0.8488 Intermediate Similarity NPC470050
0.8488 Intermediate Similarity NPC470051
0.8415 Intermediate Similarity NPC470052
0.8315 Intermediate Similarity NPC76286
0.8313 Intermediate Similarity NPC215843
0.8222 Intermediate Similarity NPC190442
0.8172 Intermediate Similarity NPC151488
0.8161 Intermediate Similarity NPC470048
0.8152 Intermediate Similarity NPC33473
0.8132 Intermediate Similarity NPC229976
0.8111 Intermediate Similarity NPC273199
0.8105 Intermediate Similarity NPC310981
0.8072 Intermediate Similarity NPC91665
0.8065 Intermediate Similarity NPC160056
0.8 Intermediate Similarity NPC40574
0.7978 Intermediate Similarity NPC128644
0.7955 Intermediate Similarity NPC269638
0.7952 Intermediate Similarity NPC198473
0.7895 Intermediate Similarity NPC98868
0.7889 Intermediate Similarity NPC478259
0.7889 Intermediate Similarity NPC478261
0.7889 Intermediate Similarity NPC478260
0.7865 Intermediate Similarity NPC264127
0.7835 Intermediate Similarity NPC185530
0.7816 Intermediate Similarity NPC100297
0.7802 Intermediate Similarity NPC2983
0.7802 Intermediate Similarity NPC177141
0.7802 Intermediate Similarity NPC469323
0.7789 Intermediate Similarity NPC291634
0.7789 Intermediate Similarity NPC126815
0.7778 Intermediate Similarity NPC93778
0.7766 Intermediate Similarity NPC171395
0.7766 Intermediate Similarity NPC84383
0.7766 Intermediate Similarity NPC281134
0.7765 Intermediate Similarity NPC63020
0.7755 Intermediate Similarity NPC26478
0.7753 Intermediate Similarity NPC470223
0.7753 Intermediate Similarity NPC471224
0.7738 Intermediate Similarity NPC474231
0.7727 Intermediate Similarity NPC477852
0.7717 Intermediate Similarity NPC253177
0.7717 Intermediate Similarity NPC280592
0.7717 Intermediate Similarity NPC320026
0.7717 Intermediate Similarity NPC213636
0.7701 Intermediate Similarity NPC147066
0.7692 Intermediate Similarity NPC472220
0.7692 Intermediate Similarity NPC97884
0.7684 Intermediate Similarity NPC322063
0.7684 Intermediate Similarity NPC78473
0.7654 Intermediate Similarity NPC182815
0.7647 Intermediate Similarity NPC474230
0.7647 Intermediate Similarity NPC475025
0.7647 Intermediate Similarity NPC475027
0.764 Intermediate Similarity NPC59453
0.764 Intermediate Similarity NPC221758
0.764 Intermediate Similarity NPC312660
0.7634 Intermediate Similarity NPC296114
0.7634 Intermediate Similarity NPC475806
0.7634 Intermediate Similarity NPC471329
0.7634 Intermediate Similarity NPC218301
0.7619 Intermediate Similarity NPC293803
0.7619 Intermediate Similarity NPC255650
0.7614 Intermediate Similarity NPC260956
0.7614 Intermediate Similarity NPC193347
0.7609 Intermediate Similarity NPC474844
0.7609 Intermediate Similarity NPC305039
0.7609 Intermediate Similarity NPC262043
0.7604 Intermediate Similarity NPC76266
0.7604 Intermediate Similarity NPC10057
0.7604 Intermediate Similarity NPC110937
0.76 Intermediate Similarity NPC189863
0.76 Intermediate Similarity NPC60681
0.7586 Intermediate Similarity NPC267517
0.7582 Intermediate Similarity NPC75315
0.7582 Intermediate Similarity NPC58063
0.7582 Intermediate Similarity NPC477228
0.7582 Intermediate Similarity NPC136948
0.7582 Intermediate Similarity NPC163016
0.7561 Intermediate Similarity NPC477856
0.7561 Intermediate Similarity NPC214770
0.7558 Intermediate Similarity NPC469996
0.7556 Intermediate Similarity NPC474083
0.7556 Intermediate Similarity NPC469948
0.7556 Intermediate Similarity NPC29447
0.7556 Intermediate Similarity NPC469993
0.7553 Intermediate Similarity NPC475700
0.7553 Intermediate Similarity NPC169343
0.7553 Intermediate Similarity NPC474736
0.7551 Intermediate Similarity NPC473174
0.7551 Intermediate Similarity NPC168319
0.7551 Intermediate Similarity NPC476897
0.7551 Intermediate Similarity NPC194028
0.7531 Intermediate Similarity NPC20610
0.7528 Intermediate Similarity NPC170862
0.7528 Intermediate Similarity NPC470558
0.7528 Intermediate Similarity NPC167103
0.7527 Intermediate Similarity NPC48010
0.7527 Intermediate Similarity NPC198818
0.7527 Intermediate Similarity NPC8062
0.7526 Intermediate Similarity NPC124703
0.7526 Intermediate Similarity NPC234617
0.7525 Intermediate Similarity NPC144459
0.7525 Intermediate Similarity NPC475294
0.7525 Intermediate Similarity NPC91034
0.75 Intermediate Similarity NPC28227
0.75 Intermediate Similarity NPC38350
0.75 Intermediate Similarity NPC474484
0.75 Intermediate Similarity NPC323005
0.75 Intermediate Similarity NPC193360
0.75 Intermediate Similarity NPC201912
0.75 Intermediate Similarity NPC103754
0.7476 Intermediate Similarity NPC473627
0.7476 Intermediate Similarity NPC16270
0.7476 Intermediate Similarity NPC37116
0.7474 Intermediate Similarity NPC292793
0.7474 Intermediate Similarity NPC8993
0.7473 Intermediate Similarity NPC469994
0.7473 Intermediate Similarity NPC472863
0.7473 Intermediate Similarity NPC474778
0.7473 Intermediate Similarity NPC145879
0.7473 Intermediate Similarity NPC195640
0.7473 Intermediate Similarity NPC474732
0.7473 Intermediate Similarity NPC51014
0.7473 Intermediate Similarity NPC31564
0.7473 Intermediate Similarity NPC474733
0.7471 Intermediate Similarity NPC201459
0.7471 Intermediate Similarity NPC477371
0.7471 Intermediate Similarity NPC231431
0.7471 Intermediate Similarity NPC192744
0.7471 Intermediate Similarity NPC471475
0.747 Intermediate Similarity NPC234707
0.747 Intermediate Similarity NPC470078
0.747 Intermediate Similarity NPC115023
0.747 Intermediate Similarity NPC305501
0.7451 Intermediate Similarity NPC177064
0.7449 Intermediate Similarity NPC473176
0.7449 Intermediate Similarity NPC201406
0.7447 Intermediate Similarity NPC262870
0.7447 Intermediate Similarity NPC177641
0.7447 Intermediate Similarity NPC49420
0.7447 Intermediate Similarity NPC272746
0.7444 Intermediate Similarity NPC472480
0.7444 Intermediate Similarity NPC82902
0.7444 Intermediate Similarity NPC156981
0.7444 Intermediate Similarity NPC144258
0.7444 Intermediate Similarity NPC214043
0.7444 Intermediate Similarity NPC85774
0.7442 Intermediate Similarity NPC66105
0.7429 Intermediate Similarity NPC122056
0.7423 Intermediate Similarity NPC107243
0.7423 Intermediate Similarity NPC57416
0.7419 Intermediate Similarity NPC473999
0.7419 Intermediate Similarity NPC32830
0.7419 Intermediate Similarity NPC284561
0.7419 Intermediate Similarity NPC173042
0.7419 Intermediate Similarity NPC309603
0.7419 Intermediate Similarity NPC76879
0.7419 Intermediate Similarity NPC474245
0.7419 Intermediate Similarity NPC474570
0.7416 Intermediate Similarity NPC320514
0.7416 Intermediate Similarity NPC163236
0.7416 Intermediate Similarity NPC145143
0.7416 Intermediate Similarity NPC251779
0.7416 Intermediate Similarity NPC328351
0.7416 Intermediate Similarity NPC327969
0.7416 Intermediate Similarity NPC69101
0.7416 Intermediate Similarity NPC240302
0.7416 Intermediate Similarity NPC321289
0.7416 Intermediate Similarity NPC310989
0.7416 Intermediate Similarity NPC151519
0.7404 Intermediate Similarity NPC474315
0.74 Intermediate Similarity NPC112009
0.74 Intermediate Similarity NPC36688
0.74 Intermediate Similarity NPC222153
0.74 Intermediate Similarity NPC180204
0.74 Intermediate Similarity NPC470954
0.7396 Intermediate Similarity NPC127197
0.7396 Intermediate Similarity NPC280877
0.7396 Intermediate Similarity NPC293052
0.7391 Intermediate Similarity NPC475740
0.7391 Intermediate Similarity NPC317590
0.7391 Intermediate Similarity NPC171722
0.7391 Intermediate Similarity NPC90652
0.7386 Intermediate Similarity NPC474509
0.7386 Intermediate Similarity NPC195424
0.7386 Intermediate Similarity NPC233332
0.7386 Intermediate Similarity NPC37038
0.7381 Intermediate Similarity NPC474228
0.7381 Intermediate Similarity NPC303613
0.7381 Intermediate Similarity NPC279241
0.7381 Intermediate Similarity NPC251705
0.7374 Intermediate Similarity NPC235142
0.7374 Intermediate Similarity NPC474327
0.7368 Intermediate Similarity NPC472871
0.7363 Intermediate Similarity NPC157257
0.7363 Intermediate Similarity NPC274448

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC137493 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.7865 Intermediate Similarity NPD6098 Approved
0.7826 Intermediate Similarity NPD5693 Phase 1
0.7692 Intermediate Similarity NPD7513 Clinical (unspecified phase)
0.764 Intermediate Similarity NPD4786 Approved
0.7614 Intermediate Similarity NPD4221 Approved
0.7614 Intermediate Similarity NPD4223 Phase 3
0.7609 Intermediate Similarity NPD6080 Approved
0.7609 Intermediate Similarity NPD6904 Approved
0.7609 Intermediate Similarity NPD6673 Approved
0.7556 Intermediate Similarity NPD5329 Approved
0.75 Intermediate Similarity NPD6672 Approved
0.75 Intermediate Similarity NPD5208 Approved
0.75 Intermediate Similarity NPD5737 Approved
0.7473 Intermediate Similarity NPD7146 Approved
0.7473 Intermediate Similarity NPD7521 Approved
0.7473 Intermediate Similarity NPD7334 Approved
0.7473 Intermediate Similarity NPD6409 Approved
0.7473 Intermediate Similarity NPD6684 Approved
0.7473 Intermediate Similarity NPD5330 Approved
0.7444 Intermediate Similarity NPD4197 Approved
0.7416 Intermediate Similarity NPD3667 Approved
0.7368 Intermediate Similarity NPD6399 Phase 3
0.7349 Intermediate Similarity NPD4747 Approved
0.734 Intermediate Similarity NPD5207 Approved
0.7312 Intermediate Similarity NPD6903 Approved
0.7283 Intermediate Similarity NPD4138 Approved
0.7283 Intermediate Similarity NPD4689 Approved
0.7283 Intermediate Similarity NPD4519 Discontinued
0.7283 Intermediate Similarity NPD4690 Approved
0.7283 Intermediate Similarity NPD4623 Approved
0.7283 Intermediate Similarity NPD4688 Approved
0.7283 Intermediate Similarity NPD4693 Phase 3
0.7283 Intermediate Similarity NPD5205 Approved
0.7283 Intermediate Similarity NPD5690 Phase 2
0.7263 Intermediate Similarity NPD5694 Approved
0.7263 Intermediate Similarity NPD6050 Approved
0.7253 Intermediate Similarity NPD3668 Phase 3
0.7234 Intermediate Similarity NPD6051 Approved
0.7229 Intermediate Similarity NPD4137 Phase 3
0.7222 Intermediate Similarity NPD7115 Discovery
0.7222 Intermediate Similarity NPD4752 Clinical (unspecified phase)
0.7216 Intermediate Similarity NPD6356 Clinical (unspecified phase)
0.7204 Intermediate Similarity NPD3573 Approved
0.7158 Intermediate Similarity NPD5692 Phase 3
0.7143 Intermediate Similarity NPD4691 Approved
0.7143 Intermediate Similarity NPD4788 Approved
0.7113 Intermediate Similarity NPD6001 Approved
0.7108 Intermediate Similarity NPD3621 Clinical (unspecified phase)
0.7097 Intermediate Similarity NPD4694 Approved
0.7097 Intermediate Similarity NPD5280 Approved
0.7093 Intermediate Similarity NPD5733 Approved
0.7093 Intermediate Similarity NPD4785 Approved
0.7093 Intermediate Similarity NPD4058 Approved
0.7093 Intermediate Similarity NPD4784 Approved
0.7093 Intermediate Similarity NPD4687 Approved
0.7083 Intermediate Similarity NPD6079 Approved
0.7079 Intermediate Similarity NPD4195 Approved
0.7071 Intermediate Similarity NPD6084 Phase 2
0.7071 Intermediate Similarity NPD6083 Phase 2
0.7065 Intermediate Similarity NPD3665 Phase 1
0.7065 Intermediate Similarity NPD3133 Approved
0.7065 Intermediate Similarity NPD3666 Approved
0.7053 Intermediate Similarity NPD5328 Approved
0.7053 Intermediate Similarity NPD4753 Phase 2
0.7 Intermediate Similarity NPD7638 Approved
0.6966 Remote Similarity NPD3617 Approved
0.6931 Remote Similarity NPD7640 Approved
0.6931 Remote Similarity NPD7639 Approved
0.6923 Remote Similarity NPD4139 Approved
0.6923 Remote Similarity NPD4692 Approved
0.6915 Remote Similarity NPD3618 Phase 1
0.6915 Remote Similarity NPD3574 Clinical (unspecified phase)
0.6907 Remote Similarity NPD5284 Approved
0.6907 Remote Similarity NPD5281 Approved
0.6905 Remote Similarity NPD5361 Clinical (unspecified phase)
0.6905 Remote Similarity NPD5360 Phase 3
0.6869 Remote Similarity NPD4629 Approved
0.6869 Remote Similarity NPD5210 Approved
0.6869 Remote Similarity NPD5695 Phase 3
0.686 Remote Similarity NPD4243 Approved
0.686 Remote Similarity NPD5276 Approved
0.6837 Remote Similarity NPD4202 Approved
0.6832 Remote Similarity NPD5696 Approved
0.6813 Remote Similarity NPD4695 Discontinued
0.6809 Remote Similarity NPD7520 Clinical (unspecified phase)
0.6809 Remote Similarity NPD1694 Approved
0.6771 Remote Similarity NPD4518 Approved
0.6768 Remote Similarity NPD7900 Approved
0.6768 Remote Similarity NPD7901 Clinical (unspecified phase)
0.6768 Remote Similarity NPD7748 Approved
0.6737 Remote Similarity NPD5279 Phase 3
0.6735 Remote Similarity NPD8034 Phase 2
0.6735 Remote Similarity NPD8035 Phase 2
0.6731 Remote Similarity NPD6052 Approved
0.6701 Remote Similarity NPD7285 Clinical (unspecified phase)
0.67 Remote Similarity NPD5654 Approved
0.6698 Remote Similarity NPD6614 Approved
0.6667 Remote Similarity NPD5777 Approved
0.6636 Remote Similarity NPD6881 Approved
0.6636 Remote Similarity NPD6899 Approved
0.6635 Remote Similarity NPD5211 Phase 2
0.6634 Remote Similarity NPD5221 Approved
0.6634 Remote Similarity NPD5222 Approved
0.6634 Remote Similarity NPD5220 Clinical (unspecified phase)
0.6633 Remote Similarity NPD4096 Approved
0.663 Remote Similarity NPD7525 Registered
0.6629 Remote Similarity NPD6942 Approved
0.6629 Remote Similarity NPD7339 Approved
0.6629 Remote Similarity NPD8039 Approved
0.6604 Remote Similarity NPD6675 Approved
0.6604 Remote Similarity NPD7128 Approved
0.6604 Remote Similarity NPD6402 Approved
0.6604 Remote Similarity NPD5739 Approved
0.6604 Remote Similarity NPD6008 Approved
0.6602 Remote Similarity NPD5286 Approved
0.6602 Remote Similarity NPD5285 Approved
0.6602 Remote Similarity NPD4696 Approved
0.6593 Remote Similarity NPD5784 Clinical (unspecified phase)
0.6569 Remote Similarity NPD5959 Approved
0.6569 Remote Similarity NPD5173 Approved
0.6569 Remote Similarity NPD4755 Approved
0.6569 Remote Similarity NPD7902 Approved
0.6566 Remote Similarity NPD7515 Phase 2
0.6552 Remote Similarity NPD7457 Clinical (unspecified phase)
0.6552 Remote Similarity NPD4789 Approved
0.6542 Remote Similarity NPD5697 Approved
0.6538 Remote Similarity NPD5223 Approved
0.6517 Remote Similarity NPD6926 Approved
0.6517 Remote Similarity NPD6924 Approved
0.6514 Remote Similarity NPD6883 Approved
0.6514 Remote Similarity NPD7102 Approved
0.6514 Remote Similarity NPD7290 Approved
0.6509 Remote Similarity NPD5141 Approved
0.65 Remote Similarity NPD5133 Approved
0.6481 Remote Similarity NPD7320 Approved
0.6481 Remote Similarity NPD6011 Approved
0.6477 Remote Similarity NPD4808 Clinical (unspecified phase)
0.6477 Remote Similarity NPD6081 Approved
0.6477 Remote Similarity NPD4809 Clinical (unspecified phase)
0.6477 Remote Similarity NPD4758 Discontinued
0.6476 Remote Similarity NPD5091 Approved
0.6476 Remote Similarity NPD5225 Approved
0.6476 Remote Similarity NPD5226 Approved
0.6476 Remote Similarity NPD4633 Approved
0.6476 Remote Similarity NPD5224 Approved
0.6471 Remote Similarity NPD4224 Phase 2
0.6471 Remote Similarity NPD4697 Phase 3
0.6465 Remote Similarity NPD5785 Approved
0.6455 Remote Similarity NPD6650 Approved
0.6455 Remote Similarity NPD6869 Approved
0.6455 Remote Similarity NPD8130 Phase 1
0.6455 Remote Similarity NPD6847 Approved
0.6455 Remote Similarity NPD6617 Approved
0.6455 Remote Similarity NPD6649 Approved
0.6444 Remote Similarity NPD5275 Approved
0.6444 Remote Similarity NPD4190 Phase 3
0.6442 Remote Similarity NPD4700 Approved
0.6436 Remote Similarity NPD5769 Clinical (unspecified phase)
0.6422 Remote Similarity NPD6012 Approved
0.6422 Remote Similarity NPD6372 Approved
0.6422 Remote Similarity NPD6373 Approved
0.6422 Remote Similarity NPD6013 Approved
0.6422 Remote Similarity NPD6014 Approved
0.6421 Remote Similarity NPD6695 Phase 3
0.6415 Remote Similarity NPD5175 Approved
0.6415 Remote Similarity NPD5174 Approved
0.64 Remote Similarity NPD7637 Suspended
0.6396 Remote Similarity NPD6053 Discontinued
0.6396 Remote Similarity NPD6882 Approved
0.6396 Remote Similarity NPD8297 Approved
0.6389 Remote Similarity NPD6412 Phase 2
0.6389 Remote Similarity NPD5701 Approved
0.6374 Remote Similarity NPD3701 Clinical (unspecified phase)
0.6374 Remote Similarity NPD6933 Approved
0.6364 Remote Similarity NPD4244 Approved
0.6364 Remote Similarity NPD4245 Approved
0.6354 Remote Similarity NPD7338 Clinical (unspecified phase)
0.6353 Remote Similarity NPD3171 Clinical (unspecified phase)
0.6339 Remote Similarity NPD7094 Approved
0.6339 Remote Similarity NPD6858 Approved
0.6327 Remote Similarity NPD4751 Clinical (unspecified phase)
0.6321 Remote Similarity NPD7632 Discontinued
0.6311 Remote Similarity NPD7732 Phase 3
0.6306 Remote Similarity NPD6401 Clinical (unspecified phase)
0.6303 Remote Similarity NPD7507 Approved
0.6286 Remote Similarity NPD6404 Discontinued
0.6277 Remote Similarity NPD7514 Phase 3
0.6277 Remote Similarity NPD6930 Phase 2
0.6277 Remote Similarity NPD6931 Approved
0.6264 Remote Similarity NPD3702 Approved
0.6262 Remote Similarity NPD4754 Approved
0.625 Remote Similarity NPD3698 Phase 2
0.625 Remote Similarity NPD3700 Clinical (unspecified phase)
0.625 Remote Similarity NPD3699 Clinical (unspecified phase)
0.625 Remote Similarity NPD5362 Discontinued
0.625 Remote Similarity NPD3527 Clinical (unspecified phase)
0.6237 Remote Similarity NPD7322 Clinical (unspecified phase)
0.6237 Remote Similarity NPD5364 Discontinued
0.6211 Remote Similarity NPD5369 Approved
0.6211 Remote Similarity NPD8028 Phase 2

Structure

External Identifiers

PubChem CID   50908217
ChEMBL   CHEMBL1651317
ZINC  

Physicochemical Properties

Molecular Weight:  440.37
ALogP:  3.234
MLogP:  4.54
XLogP:  8.794
# Rotatable Bonds:  9
Polar Surface Area:  26.3
# H-Bond Aceptor:  2
# H-Bond Donor:  0
# Rings:  5
# Heavy Atoms:  32

Download Data

Data Type Select
General Info & Identifiers & Properties  
Structure MOL file  
Source Organisms  
Biological Activities  
Similar NPs/Drugs