Natural Product: NPC108948

Natural Product ID:  NPC108948
Common Name:   (3R,4Ar,10As)-3,4A-Dichloro-10A-[[(1S,3S,6S)-3-Chloro-6-Hydroxy-2,2,6-Trimethylcyclohexyl]Methyl]-6,8-Dihydroxy-2,2,7-Trimethyl-3,4-Dihydrobenzo[G]Chromene-5,10-Dione
IUPAC Name:   (3R,4aR,10aS)-3,4a-dichloro-10a-[[(1S,3S,6S)-3-chloro-6-hydroxy-2,2,6-trimethylcyclohexyl]methyl]-6,8-dihydroxy-2,2,7-trimethyl-3,4-dihydrobenzo[g]chromene-5,10-dione
Synonyms:  
Molecular Formula:   C26H33Cl3O6
Standard InCHIKey:  XGGIVXWAYKZBIV-CYGDAPSSSA-N
Standard InCHI:  InChI=1S/C26H33Cl3O6/c1-12-14(30)9-13-18(19(12)31)21(33)25(29)11-17(28)23(4,5)35-26(25,20(13)32)10-15-22(2,3)16(27)7-8-24(15,6)34/h9,15-17,30-31,34H,7-8,10-11H2,1-6H3/t15-,16-,17+,24-,25-,26-/m0/s1
Canonical SMILES:  Oc1cc2c(c(c1C)O)C(=O)[C@@]1([C@@](C2=O)(C[C@@H]2[C@@](C)(O)CC[C@@H](C2(C)C)Cl)OC([C@@H](C1)Cl)(C)C)Cl
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO32475 actinomycete sp. Species NA NA PMID[24328269]

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT393 Cell Line HCT-116 Homo sapiens IC50 = 15000 nM 24467317

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC108948 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
0.9873 High Similarity NPC301846
0.9748 High Similarity NPC311679
0.9748 High Similarity NPC131078
0.9627 High Similarity NPC184518
0.9394 High Similarity NPC471684
0.9321 High Similarity NPC73544
0.9162 High Similarity NPC158699
0.897 High Similarity NPC471685
0.8889 High Similarity NPC471686
0.8462 Intermediate Similarity NPC471687
0.8214 Intermediate Similarity NPC470564
0.814 Intermediate Similarity NPC470563
0.8118 Intermediate Similarity NPC470559
0.8081 Intermediate Similarity NPC470561
0.8075 Intermediate Similarity NPC181560
0.8075 Intermediate Similarity NPC169452
0.8012 Intermediate Similarity NPC138099
0.8012 Intermediate Similarity NPC242994
0.8 Intermediate Similarity NPC471905
0.7989 Intermediate Similarity NPC316262
0.7989 Intermediate Similarity NPC314653
0.7988 Intermediate Similarity NPC471906
0.7977 Intermediate Similarity NPC475106
0.7975 Intermediate Similarity NPC193555
0.7937 Intermediate Similarity NPC254847
0.7937 Intermediate Similarity NPC191976
0.7914 Intermediate Similarity NPC246638
0.791 Intermediate Similarity NPC277865
0.791 Intermediate Similarity NPC470565
0.791 Intermediate Similarity NPC470562
0.791 Intermediate Similarity NPC474004
0.7901 Intermediate Similarity NPC143438
0.7892 Intermediate Similarity NPC470570
0.7888 Intermediate Similarity NPC53414
0.7888 Intermediate Similarity NPC53206
0.7877 Intermediate Similarity NPC264922
0.7866 Intermediate Similarity NPC308572
0.7866 Intermediate Similarity NPC135524
0.7866 Intermediate Similarity NPC474961
0.7865 Intermediate Similarity NPC470560
0.7849 Intermediate Similarity NPC197326
0.7849 Intermediate Similarity NPC201127
0.7849 Intermediate Similarity NPC272196
0.7849 Intermediate Similarity NPC474637
0.7844 Intermediate Similarity NPC37709
0.7841 Intermediate Similarity NPC125465
0.7831 Intermediate Similarity NPC34482
0.7809 Intermediate Similarity NPC315306
0.7809 Intermediate Similarity NPC313717
0.7805 Intermediate Similarity NPC110810
0.7805 Intermediate Similarity NPC204045
0.7805 Intermediate Similarity NPC305845
0.7803 Intermediate Similarity NPC472617
0.7791 Intermediate Similarity NPC190457
0.7791 Intermediate Similarity NPC280497
0.7778 Intermediate Similarity NPC472211
0.7778 Intermediate Similarity NPC53001
0.7771 Intermediate Similarity NPC244691
0.7771 Intermediate Similarity NPC48762
0.7771 Intermediate Similarity NPC21599
0.7771 Intermediate Similarity NPC193703
0.7765 Intermediate Similarity NPC305965
0.7765 Intermediate Similarity NPC474857
0.7759 Intermediate Similarity NPC472618
0.7759 Intermediate Similarity NPC313368
0.7753 Intermediate Similarity NPC54903
0.7753 Intermediate Similarity NPC286074
0.775 Intermediate Similarity NPC267205
0.7738 Intermediate Similarity NPC312929
0.7738 Intermediate Similarity NPC126767
0.7738 Intermediate Similarity NPC190648
0.7738 Intermediate Similarity NPC56433
0.7738 Intermediate Similarity NPC245584
0.7738 Intermediate Similarity NPC289042
0.7738 Intermediate Similarity NPC118027
0.773 Intermediate Similarity NPC87723
0.7727 Intermediate Similarity NPC100849
0.7725 Intermediate Similarity NPC28632
0.7725 Intermediate Similarity NPC470674
0.7725 Intermediate Similarity NPC12402
0.7725 Intermediate Similarity NPC470673
0.7725 Intermediate Similarity NPC117716
0.7725 Intermediate Similarity NPC474630
0.7722 Intermediate Similarity NPC303910
0.7719 Intermediate Similarity NPC154683
0.7719 Intermediate Similarity NPC142527
0.7719 Intermediate Similarity NPC40356
0.7716 Intermediate Similarity NPC474311
0.7714 Intermediate Similarity NPC103816
0.7714 Intermediate Similarity NPC61382
0.7714 Intermediate Similarity NPC219686
0.7711 Intermediate Similarity NPC474203
0.7711 Intermediate Similarity NPC451542
0.7711 Intermediate Similarity NPC313047
0.7711 Intermediate Similarity NPC174905
0.7711 Intermediate Similarity NPC295712
0.7711 Intermediate Similarity NPC293545
0.7706 Intermediate Similarity NPC470568
0.7706 Intermediate Similarity NPC147735
0.7706 Intermediate Similarity NPC294646
0.7705 Intermediate Similarity NPC151292
0.7702 Intermediate Similarity NPC166480
0.7702 Intermediate Similarity NPC282780
0.7702 Intermediate Similarity NPC44437
0.7697 Intermediate Similarity NPC290550
0.7692 Intermediate Similarity NPC142846
0.7692 Intermediate Similarity NPC94781
0.7688 Intermediate Similarity NPC4547
0.7679 Intermediate Similarity NPC271944
0.7679 Intermediate Similarity NPC85393
0.7679 Intermediate Similarity NPC473135
0.7679 Intermediate Similarity NPC470676
0.7679 Intermediate Similarity NPC110882
0.7679 Intermediate Similarity NPC136878
0.7679 Intermediate Similarity NPC473132
0.7676 Intermediate Similarity NPC191606
0.7674 Intermediate Similarity NPC214632
0.7674 Intermediate Similarity NPC470408
0.7674 Intermediate Similarity NPC182921
0.7674 Intermediate Similarity NPC218870
0.7674 Intermediate Similarity NPC474824
0.7673 Intermediate Similarity NPC108129
0.767 Intermediate Similarity NPC245122
0.7667 Intermediate Similarity NPC118128
0.7665 Intermediate Similarity NPC227841
0.7661 Intermediate Similarity NPC470569
0.7661 Intermediate Similarity NPC478148
0.7654 Intermediate Similarity NPC249272
0.7647 Intermediate Similarity NPC477566
0.7647 Intermediate Similarity NPC477567
0.7647 Intermediate Similarity NPC329933
0.7647 Intermediate Similarity NPC474310
0.7647 Intermediate Similarity NPC120171
0.7644 Intermediate Similarity NPC158542
0.764 Intermediate Similarity NPC476056
0.764 Intermediate Similarity NPC17274
0.764 Intermediate Similarity NPC85047
0.764 Intermediate Similarity NPC120857
0.7633 Intermediate Similarity NPC34802
0.7633 Intermediate Similarity NPC5568
0.763 Intermediate Similarity NPC226656
0.763 Intermediate Similarity NPC275575
0.763 Intermediate Similarity NPC66508
0.7624 Intermediate Similarity NPC470422
0.7624 Intermediate Similarity NPC469393
0.7622 Intermediate Similarity NPC13715
0.7616 Intermediate Similarity NPC45934
0.7616 Intermediate Similarity NPC470353
0.7605 Intermediate Similarity NPC471682
0.7605 Intermediate Similarity NPC100242
0.7602 Intermediate Similarity NPC315520
0.7602 Intermediate Similarity NPC255641
0.7602 Intermediate Similarity NPC205766
0.7602 Intermediate Similarity NPC290954
0.76 Intermediate Similarity NPC324736
0.76 Intermediate Similarity NPC228654
0.76 Intermediate Similarity NPC239118
0.7598 Intermediate Similarity NPC76647
0.7598 Intermediate Similarity NPC193222
0.7596 Intermediate Similarity NPC470334
0.7593 Intermediate Similarity NPC12070
0.7593 Intermediate Similarity NPC270899
0.7593 Intermediate Similarity NPC202225
0.759 Intermediate Similarity NPC92079
0.7588 Intermediate Similarity NPC112816
0.7586 Intermediate Similarity NPC474861
0.7586 Intermediate Similarity NPC192587
0.7586 Intermediate Similarity NPC470352
0.7586 Intermediate Similarity NPC470354
0.7584 Intermediate Similarity NPC472049
0.7576 Intermediate Similarity NPC114620
0.7576 Intermediate Similarity NPC103337
0.7574 Intermediate Similarity NPC143685
0.7574 Intermediate Similarity NPC285122
0.7572 Intermediate Similarity NPC178964
0.7572 Intermediate Similarity NPC280530
0.7572 Intermediate Similarity NPC95842
0.7572 Intermediate Similarity NPC329844
0.7571 Intermediate Similarity NPC470694
0.7571 Intermediate Similarity NPC473022
0.7571 Intermediate Similarity NPC94796
0.756 Intermediate Similarity NPC19896
0.756 Intermediate Similarity NPC10764
0.756 Intermediate Similarity NPC29932
0.7558 Intermediate Similarity NPC149526
0.7558 Intermediate Similarity NPC474417
0.7558 Intermediate Similarity NPC470675
0.7558 Intermediate Similarity NPC473131
0.7558 Intermediate Similarity NPC230848
0.7557 Intermediate Similarity NPC284495
0.7557 Intermediate Similarity NPC472052
0.7557 Intermediate Similarity NPC470342
0.7557 Intermediate Similarity NPC472060
0.7556 Intermediate Similarity NPC20734
0.7546 Intermediate Similarity NPC290803
0.7546 Intermediate Similarity NPC283088
0.7545 Intermediate Similarity NPC257644
0.7545 Intermediate Similarity NPC73061
0.7545 Intermediate Similarity NPC291078
0.7544 Intermediate Similarity NPC65775

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC108948 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.7937 Intermediate Similarity NPD1509 Clinical (unspecified phase)
0.7665 Intermediate Similarity NPD7390 Discontinued
0.7416 Intermediate Similarity NPD6959 Discontinued
0.7348 Intermediate Similarity NPD7473 Discontinued
0.7209 Intermediate Similarity NPD4378 Clinical (unspecified phase)
0.7182 Intermediate Similarity NPD6232 Discontinued
0.7175 Intermediate Similarity NPD7819 Suspended
0.7173 Intermediate Similarity NPD7879 Clinical (unspecified phase)
0.7143 Intermediate Similarity NPD5406 Approved
0.7143 Intermediate Similarity NPD1470 Approved
0.7143 Intermediate Similarity NPD5408 Approved
0.7143 Intermediate Similarity NPD5405 Approved
0.7143 Intermediate Similarity NPD6099 Approved
0.7143 Intermediate Similarity NPD6100 Approved
0.7143 Intermediate Similarity NPD5404 Approved
0.7135 Intermediate Similarity NPD8443 Clinical (unspecified phase)
0.7135 Intermediate Similarity NPD8438 Clinical (unspecified phase)
0.711 Intermediate Similarity NPD7410 Clinical (unspecified phase)
0.711 Intermediate Similarity NPD2533 Approved
0.711 Intermediate Similarity NPD2532 Approved
0.711 Intermediate Similarity NPD2534 Approved
0.7083 Intermediate Similarity NPD651 Clinical (unspecified phase)
0.7056 Intermediate Similarity NPD7075 Discontinued
0.7053 Intermediate Similarity NPD8150 Discontinued
0.7018 Intermediate Similarity NPD2800 Approved
0.7011 Intermediate Similarity NPD2403 Approved
0.7006 Intermediate Similarity NPD4380 Phase 2
0.6983 Remote Similarity NPD2393 Clinical (unspecified phase)
0.6983 Remote Similarity NPD7096 Clinical (unspecified phase)
0.6977 Remote Similarity NPD6398 Clinical (unspecified phase)
0.6961 Remote Similarity NPD3749 Approved
0.6959 Remote Similarity NPD970 Clinical (unspecified phase)
0.6949 Remote Similarity NPD3226 Approved
0.6946 Remote Similarity NPD943 Approved
0.6914 Remote Similarity NPD7422 Clinical (unspecified phase)
0.691 Remote Similarity NPD6599 Discontinued
0.6894 Remote Similarity NPD1201 Approved
0.6872 Remote Similarity NPD7411 Suspended
0.6866 Remote Similarity NPD8320 Phase 1
0.6866 Remote Similarity NPD8319 Approved
0.6864 Remote Similarity NPD6651 Approved
0.6864 Remote Similarity NPD1607 Approved
0.6837 Remote Similarity NPD6535 Approved
0.6837 Remote Similarity NPD6534 Approved
0.6828 Remote Similarity NPD6167 Clinical (unspecified phase)
0.6828 Remote Similarity NPD6166 Phase 2
0.6828 Remote Similarity NPD6168 Clinical (unspecified phase)
0.6823 Remote Similarity NPD6784 Approved
0.6823 Remote Similarity NPD6785 Approved
0.6818 Remote Similarity NPD7700 Phase 2
0.6818 Remote Similarity NPD7699 Phase 2
0.6816 Remote Similarity NPD7435 Discontinued
0.6813 Remote Similarity NPD3882 Suspended
0.6809 Remote Similarity NPD7804 Clinical (unspecified phase)
0.6809 Remote Similarity NPD5844 Phase 1
0.68 Remote Similarity NPD3300 Phase 2
0.6793 Remote Similarity NPD5494 Approved
0.6784 Remote Similarity NPD1510 Phase 2
0.678 Remote Similarity NPD1512 Approved
0.6763 Remote Similarity NPD1549 Phase 2
0.675 Remote Similarity NPD6780 Approved
0.675 Remote Similarity NPD6778 Approved
0.675 Remote Similarity NPD6779 Approved
0.675 Remote Similarity NPD6777 Approved
0.675 Remote Similarity NPD6782 Approved
0.675 Remote Similarity NPD6781 Approved
0.675 Remote Similarity NPD6776 Approved
0.6746 Remote Similarity NPD1240 Approved
0.674 Remote Similarity NPD1934 Approved
0.674 Remote Similarity NPD6801 Discontinued
0.6738 Remote Similarity NPD7852 Clinical (unspecified phase)
0.6733 Remote Similarity NPD7698 Approved
0.6733 Remote Similarity NPD7696 Phase 3
0.6733 Remote Similarity NPD7697 Approved
0.6721 Remote Similarity NPD7768 Phase 2
0.672 Remote Similarity NPD5711 Approved
0.672 Remote Similarity NPD5710 Approved
0.6705 Remote Similarity NPD1550 Clinical (unspecified phase)
0.6705 Remote Similarity NPD1552 Clinical (unspecified phase)
0.6705 Remote Similarity NPD2346 Discontinued
0.6703 Remote Similarity NPD2801 Approved
0.67 Remote Similarity NPD7870 Phase 2
0.67 Remote Similarity NPD7871 Phase 2
0.6686 Remote Similarity NPD3750 Approved
0.6686 Remote Similarity NPD3299 Clinical (unspecified phase)
0.6667 Remote Similarity NPD4363 Phase 3
0.6667 Remote Similarity NPD1511 Approved
0.6667 Remote Similarity NPD4360 Phase 2
0.663 Remote Similarity NPD4868 Clinical (unspecified phase)
0.6618 Remote Similarity NPD7874 Approved
0.6618 Remote Similarity NPD7875 Clinical (unspecified phase)
0.6615 Remote Similarity NPD7251 Discontinued
0.6612 Remote Similarity NPD1465 Phase 2
0.6602 Remote Similarity NPD7701 Phase 2
0.6595 Remote Similarity NPD4381 Clinical (unspecified phase)
0.6587 Remote Similarity NPD7801 Approved
0.658 Remote Similarity NPD7808 Phase 3
0.6579 Remote Similarity NPD3751 Discontinued
0.6576 Remote Similarity NPD3817 Phase 2
0.6573 Remote Similarity NPD6799 Approved
0.657 Remote Similarity NPD8151 Discontinued
0.6564 Remote Similarity NPD3019 Approved
0.6562 Remote Similarity NPD6797 Phase 2
0.6552 Remote Similarity NPD2796 Approved
0.6552 Remote Similarity NPD2935 Discontinued
0.6546 Remote Similarity NPD8313 Approved
0.6546 Remote Similarity NPD8312 Approved
0.6529 Remote Similarity NPD3764 Approved
0.6528 Remote Similarity NPD6559 Discontinued
0.6522 Remote Similarity NPD405 Clinical (unspecified phase)
0.651 Remote Similarity NPD7074 Phase 3
0.6505 Remote Similarity NPD7211 Clinical (unspecified phase)
0.6503 Remote Similarity NPD4196 Clinical (unspecified phase)
0.6497 Remote Similarity NPD7003 Approved
0.6495 Remote Similarity NPD4338 Clinical (unspecified phase)
0.6486 Remote Similarity NPD5402 Approved
0.6484 Remote Similarity NPD7458 Discontinued
0.648 Remote Similarity NPD8055 Clinical (unspecified phase)
0.6477 Remote Similarity NPD7993 Clinical (unspecified phase)
0.6465 Remote Similarity NPD8397 Clinical (unspecified phase)
0.6463 Remote Similarity NPD2932 Approved
0.6458 Remote Similarity NPD6020 Phase 2
0.6458 Remote Similarity NPD7054 Approved
0.6447 Remote Similarity NPD8434 Phase 2
0.6425 Remote Similarity NPD7236 Approved
0.6425 Remote Similarity NPD7472 Approved
0.6416 Remote Similarity NPD230 Phase 1
0.6406 Remote Similarity NPD3818 Discontinued
0.6404 Remote Similarity NPD4975 Approved
0.6404 Remote Similarity NPD8166 Discontinued
0.6404 Remote Similarity NPD4974 Approved
0.64 Remote Similarity NPD3748 Approved
0.64 Remote Similarity NPD2799 Discontinued
0.6393 Remote Similarity NPD5808 Clinical (unspecified phase)
0.6386 Remote Similarity NPD4361 Phase 2
0.6386 Remote Similarity NPD4362 Clinical (unspecified phase)
0.6374 Remote Similarity NPD4625 Phase 3
0.6373 Remote Similarity NPD5544 Approved
0.6373 Remote Similarity NPD7286 Phase 2
0.6369 Remote Similarity NPD6190 Approved
0.6368 Remote Similarity NPD6212 Phase 3
0.6368 Remote Similarity NPD6214 Clinical (unspecified phase)
0.6368 Remote Similarity NPD3787 Discontinued
0.6368 Remote Similarity NPD6213 Phase 3
0.6359 Remote Similarity NPD6823 Phase 2
0.6354 Remote Similarity NPD7004 Clinical (unspecified phase)
0.6348 Remote Similarity NPD7421 Clinical (unspecified phase)
0.6347 Remote Similarity NPD4878 Approved
0.6344 Remote Similarity NPD5760 Phase 2
0.6344 Remote Similarity NPD5761 Phase 2
0.6341 Remote Similarity NPD4914 Approved
0.6339 Remote Similarity NPD7239 Suspended
0.6337 Remote Similarity NPD6410 Clinical (unspecified phase)
0.6335 Remote Similarity NPD3926 Phase 2
0.6331 Remote Similarity NPD1164 Approved
0.6328 Remote Similarity NPD2344 Approved
0.6328 Remote Similarity NPD1471 Phase 3
0.6316 Remote Similarity NPD1247 Approved
0.6313 Remote Similarity NPD8155 Clinical (unspecified phase)
0.6313 Remote Similarity NPD1878 Clinical (unspecified phase)
0.6308 Remote Similarity NPD5953 Discontinued
0.6301 Remote Similarity NPD6663 Approved
0.6284 Remote Similarity NPD5403 Approved
0.6284 Remote Similarity NPD920 Approved
0.6283 Remote Similarity NPD7229 Phase 3
0.628 Remote Similarity NPD4387 Approved
0.628 Remote Similarity NPD4386 Approved
0.6271 Remote Similarity NPD1551 Phase 2
0.6262 Remote Similarity NPD7501 Clinical (unspecified phase)
0.6257 Remote Similarity NPD1243 Approved
0.6257 Remote Similarity NPD5736 Approved
0.625 Remote Similarity NPD9269 Phase 2
0.6244 Remote Similarity NPD4419 Clinical (unspecified phase)
0.6243 Remote Similarity NPD4907 Clinical (unspecified phase)
0.6237 Remote Similarity NPD7799 Discontinued
0.6237 Remote Similarity NPD7228 Approved
0.6228 Remote Similarity NPD4879 Approved
0.6228 Remote Similarity NPD3026 Approved
0.6228 Remote Similarity NPD3023 Approved
0.6222 Remote Similarity NPD4628 Phase 3
0.6219 Remote Similarity NPD4287 Approved
0.6213 Remote Similarity NPD4749 Approved
0.6211 Remote Similarity NPD6234 Discontinued
0.6211 Remote Similarity NPD5537 Clinical (unspecified phase)
0.6211 Remote Similarity NPD919 Approved
0.6207 Remote Similarity NPD7961 Discontinued
0.6205 Remote Similarity NPD3025 Approved
0.6205 Remote Similarity NPD9268 Approved
0.6205 Remote Similarity NPD3024 Approved
0.6203 Remote Similarity NPD37 Approved
0.6197 Remote Similarity NPD7782 Clinical (unspecified phase)
0.6197 Remote Similarity NPD7783 Phase 2
0.6195 Remote Similarity NPD8090 Clinical (unspecified phase)
0.6195 Remote Similarity NPD5543 Approved
0.6195 Remote Similarity NPD4388 Approved
0.6195 Remote Similarity NPD4915 Approved
0.6193 Remote Similarity NPD5027 Approved
0.6193 Remote Similarity NPD5029 Approved
0.6193 Remote Similarity NPD5031 Approved
0.619 Remote Similarity NPD4967 Phase 2

Structure

External Identifiers

PubChem CID   14650471
ChEMBL   CHEMBL3104877
ZINC  

Physicochemical Properties

Molecular Weight:  546.13
ALogP:  2.0559
MLogP:  3.33
XLogP:  3.127
# Rotatable Bonds:  14
Polar Surface Area:  104.06
# H-Bond Aceptor:  4
# H-Bond Donor:  3
# Rings:  4
# Heavy Atoms:  35

Download Data

Data Type Select
General Info & Identifiers & Properties  
Structure MOL file  
Source Organisms  
Biological Activities  
Similar NPs/Drugs