Collective Molecular Activities of the Plant: Grevillea Robusta
Plant ID: NPO8945
Plant Latin Name: Grevillea Robusta
Taxonomy Genus: Grevillea
Taxonomy Family: Proteaceae
Plant External Links:
NCBI TaxonomyDB:
105748
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
107 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
21 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
50 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC98200
Ingredient ID: NPC9592
Ingredient ID: NPC93202
Ingredient ID: NPC92212
Ingredient ID: NPC91204
Ingredient ID: NPC88773
Ingredient ID: NPC86785
Ingredient ID: NPC86678
Ingredient ID: NPC86078
Ingredient ID: NPC82299
Ingredient ID: NPC76453
Ingredient ID: NPC73464
Ingredient ID: NPC69952
Ingredient ID: NPC68352
Ingredient ID: NPC65238
Ingredient ID: NPC64092
Ingredient ID: NPC60087
Ingredient ID: NPC49651
Ingredient ID: NPC49315
Ingredient ID: NPC48781
Ingredient ID: NPC473221
Ingredient ID: NPC470760
Ingredient ID: NPC470759
Ingredient ID: NPC470752
Ingredient ID: NPC470700
Ingredient ID: NPC470699
Ingredient ID: NPC46663
Ingredient ID: NPC45539
Ingredient ID: NPC45112
Ingredient ID: NPC39430
Ingredient ID: NPC32715
Ingredient ID: NPC309787
Ingredient ID: NPC309757
Ingredient ID: NPC307281
Ingredient ID: NPC306804
Ingredient ID: NPC30390
Ingredient ID: NPC298088
Ingredient ID: NPC295409
Ingredient ID: NPC291440
Ingredient ID: NPC288208
Ingredient ID: NPC277091
Ingredient ID: NPC274836
Ingredient ID: NPC273801
Ingredient ID: NPC271958
Ingredient ID: NPC269383
Ingredient ID: NPC266149
Ingredient ID: NPC263507
Ingredient ID: NPC2603
Ingredient ID: NPC259716
Ingredient ID: NPC258637
Ingredient ID: NPC25464
Ingredient ID: NPC246889
Ingredient ID: NPC246056
Ingredient ID: NPC244509
Ingredient ID: NPC244336
Ingredient ID: NPC23804
Ingredient ID: NPC233924
Ingredient ID: NPC2304
Ingredient ID: NPC229519
Ingredient ID: NPC227908
Ingredient ID: NPC227778
Ingredient ID: NPC226130
Ingredient ID: NPC224925
Ingredient ID: NPC219424
Ingredient ID: NPC218754
Ingredient ID: NPC217981
Ingredient ID: NPC214723
Ingredient ID: NPC212699
Ingredient ID: NPC209959
Ingredient ID: NPC207675
Ingredient ID: NPC205424
Ingredient ID: NPC19822
Ingredient ID: NPC19661
Ingredient ID: NPC193019
Ingredient ID: NPC189454
Ingredient ID: NPC188942
Ingredient ID: NPC188703
Ingredient ID: NPC181361
Ingredient ID: NPC178292
Ingredient ID: NPC177849
Ingredient ID: NPC174729
Ingredient ID: NPC168303
Ingredient ID: NPC163176
Ingredient ID: NPC156380
Ingredient ID: NPC153904
Ingredient ID: NPC151030
Ingredient ID: NPC150484
Ingredient ID: NPC149925
Ingredient ID: NPC148634
Ingredient ID: NPC147310
Ingredient ID: NPC140750
Ingredient ID: NPC139774
Ingredient ID: NPC137791
Ingredient ID: NPC134413
Ingredient ID: NPC132771
Ingredient ID: NPC129717
Ingredient ID: NPC122175
Ingredient ID: NPC119309
Ingredient ID: NPC115808
Ingredient ID: NPC114064
Ingredient ID: NPC111723
Ingredient ID: NPC110129
Ingredient ID: NPC108679
Ingredient ID: NPC10829
Ingredient ID: NPC108228
Ingredient ID: NPC107225
Ingredient ID: NPC105107
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials |
|---|
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
