Collective Molecular Activities of the Plant: Monachosorum Henryi
Plant ID: NPO7116
Plant Latin Name: Monachosorum Henryi
Taxonomy Genus: Monachosorum
Taxonomy Family: Dennstaedtiaceae
Plant External Links:
NCBI TaxonomyDB:
32150
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
52 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
12 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
6 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99371
Ingredient ID: NPC99241
Ingredient ID: NPC93471
Ingredient ID: NPC90012
Ingredient ID: NPC86060
Ingredient ID: NPC81304
Ingredient ID: NPC78226
Ingredient ID: NPC76340
Ingredient ID: NPC75661
Ingredient ID: NPC71709
Ingredient ID: NPC70180
Ingredient ID: NPC64217
Ingredient ID: NPC58781
Ingredient ID: NPC54839
Ingredient ID: NPC48916
Ingredient ID: NPC4567
Ingredient ID: NPC40302
Ingredient ID: NPC306499
Ingredient ID: NPC3032
Ingredient ID: NPC299444
Ingredient ID: NPC292697
Ingredient ID: NPC274759
Ingredient ID: NPC269121
Ingredient ID: NPC24897
Ingredient ID: NPC248020
Ingredient ID: NPC247301
Ingredient ID: NPC245731
Ingredient ID: NPC245272
Ingredient ID: NPC242688
Ingredient ID: NPC238577
Ingredient ID: NPC237938
Ingredient ID: NPC232884
Ingredient ID: NPC221459
Ingredient ID: NPC221301
Ingredient ID: NPC210828
Ingredient ID: NPC201915
Ingredient ID: NPC197843
Ingredient ID: NPC193517
Ingredient ID: NPC178046
Ingredient ID: NPC167894
Ingredient ID: NPC16079
Ingredient ID: NPC154903
Ingredient ID: NPC151698
Ingredient ID: NPC151286
Ingredient ID: NPC141411
Ingredient ID: NPC137922
Ingredient ID: NPC133289
Ingredient ID: NPC132889
Ingredient ID: NPC132017
Ingredient ID: NPC126582
Ingredient ID: NPC123676
Ingredient ID: NPC114834
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials |
|---|
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
ALOX15,ALOX12
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
ALOX15
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
ALOX12
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
ALOX15
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
ALOX12
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ALOX15
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
ALOX15
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
ALOX15
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
ALOX15
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
ALOX15
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
ALOX15
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
ALOX15
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
ALOX12
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
