Collective Molecular Activities of the Plant: Azadirachta Indica
Country/Region:
Ghana; Lebanon; Tanzania; Indonesia; India; Togo; Senegal; Rwanda; Kenya; Sri Lanka; Thailand; Nigeria; Burkina FasoTraditional Medicine System:
Bangladesh; Sudan; Guinea; Cambodia; Rwanda; Somalia; Nigeria; Cameroon; Burkina Faso; Ghana; Cuba; El Salvador; Togo; Thailand; Haiti; Mauritania; Netherlands; Pakistan; Gambia; Tanzania; Indonesia; Mauritius; Trinidad and Tobago; Guinea-Bissau; Kenya; Dominican Republic; Jamaica; Chad; Myanmar; India; Senegal; Uganda; Sri Lanka; Lebanon; Niger; United States
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
63 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
35 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
50 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC910
Ingredient ID: NPC85762
Ingredient ID: NPC84335
Ingredient ID: NPC83706
Ingredient ID: NPC79117
Ingredient ID: NPC663
Ingredient ID: NPC61967
Ingredient ID: NPC56197
Ingredient ID: NPC5284
Ingredient ID: NPC51882
Ingredient ID: NPC5180
Ingredient ID: NPC5079
Ingredient ID: NPC470120
Ingredient ID: NPC470119
Ingredient ID: NPC470118
Ingredient ID: NPC470117
Ingredient ID: NPC470116
Ingredient ID: NPC470115
Ingredient ID: NPC470114
Ingredient ID: NPC469845
Ingredient ID: NPC469844
Ingredient ID: NPC46764
Ingredient ID: NPC38530
Ingredient ID: NPC35000
Ingredient ID: NPC34421
Ingredient ID: NPC326729
Ingredient ID: NPC326021
Ingredient ID: NPC322546
Ingredient ID: NPC308205
Ingredient ID: NPC307383
Ingredient ID: NPC302392
Ingredient ID: NPC30222
Ingredient ID: NPC292133
Ingredient ID: NPC291150
Ingredient ID: NPC272590
Ingredient ID: NPC267502
Ingredient ID: NPC264048
Ingredient ID: NPC255017
Ingredient ID: NPC25351
Ingredient ID: NPC246164
Ingredient ID: NPC239097
Ingredient ID: NPC238843
Ingredient ID: NPC237259
Ingredient ID: NPC236288
Ingredient ID: NPC224394
Ingredient ID: NPC214495
Ingredient ID: NPC210424
Ingredient ID: NPC209364
Ingredient ID: NPC208610
Ingredient ID: NPC199044
Ingredient ID: NPC197596
Ingredient ID: NPC197137
Ingredient ID: NPC194854
Ingredient ID: NPC189616
Ingredient ID: NPC185456
Ingredient ID: NPC184700
Ingredient ID: NPC177275
Ingredient ID: NPC174161
Ingredient ID: NPC167340
Ingredient ID: NPC161065
Ingredient ID: NPC137605
Ingredient ID: NPC120099
Ingredient ID: NPC116717
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 Plant level | 3 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT01251250 | Azadirachta Indica in Treating Patients With Chronic Lymphocytic Leukemia | Refractory Chronic Lymphocytic Leukemia|Stage II Chronic Lymphocytic Leukemia|Stage III Chronic Lymphocytic Leukemia|Stage IV Chronic Lymphocytic Leukemia | Azadirachta Indica | Plant level As single plant |
| NCT01731756 | Effects of Leaf Extract of Azadirachta Indica in Palmer Arsenical Keratosis | Arsenical Keratosis | Azadirachta Indica | Plant level As plant Extract |
| NCT01321645 | Efficacy of Azadirachta Indica (Homoeopathic Medicine) in Treatment of Acne Vulgaris | Acne Vulgaris | Azadirachta Indica | Plant level As single plant |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
Lymphocytic leukaemia, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH7PW5 |
NCT01251250,NCT01251250,NCT01251250,NCT01251250
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
NCT01321645
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
