Collective Molecular Activities of the Plant: Croton Hutchinsonianus
Plant ID: NPO28961
Plant Latin Name: Croton Hutchinsonianus
Taxonomy Genus: Croton
Taxonomy Family: Euphorbiaceae
Plant External Links:
NCBI TaxonomyDB:
323057
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
34 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
31 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
25 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC85932
Ingredient ID: NPC76982
Ingredient ID: NPC7433
Ingredient ID: NPC6786
Ingredient ID: NPC4687
Ingredient ID: NPC43787
Ingredient ID: NPC3207
Ingredient ID: NPC310211
Ingredient ID: NPC308137
Ingredient ID: NPC303951
Ingredient ID: NPC300991
Ingredient ID: NPC280799
Ingredient ID: NPC269367
Ingredient ID: NPC252251
Ingredient ID: NPC250351
Ingredient ID: NPC249583
Ingredient ID: NPC247803
Ingredient ID: NPC246651
Ingredient ID: NPC23294
Ingredient ID: NPC228273
Ingredient ID: NPC218034
Ingredient ID: NPC210828
Ingredient ID: NPC209174
Ingredient ID: NPC201697
Ingredient ID: NPC199277
Ingredient ID: NPC174760
Ingredient ID: NPC169402
Ingredient ID: NPC161833
Ingredient ID: NPC160381
Ingredient ID: NPC150239
Ingredient ID: NPC141504
Ingredient ID: NPC135887
Ingredient ID: NPC131885
Ingredient ID: NPC116238
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials |
|---|
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
