Collective Molecular Activities of the Plant: Aleurites Cordata
Plant ID: NPO28169
Plant Latin Name: Aleurites Cordata
Taxonomy Genus: Aleurites
Taxonomy Family: Euphorbiaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
40 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
28 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
11 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC85980
Ingredient ID: NPC7085
Ingredient ID: NPC65397
Ingredient ID: NPC59446
Ingredient ID: NPC52955
Ingredient ID: NPC51492
Ingredient ID: NPC43346
Ingredient ID: NPC40177
Ingredient ID: NPC3343
Ingredient ID: NPC306598
Ingredient ID: NPC292220
Ingredient ID: NPC280932
Ingredient ID: NPC27239
Ingredient ID: NPC272349
Ingredient ID: NPC270556
Ingredient ID: NPC266383
Ingredient ID: NPC265040
Ingredient ID: NPC26253
Ingredient ID: NPC249980
Ingredient ID: NPC248921
Ingredient ID: NPC245930
Ingredient ID: NPC230705
Ingredient ID: NPC230226
Ingredient ID: NPC226690
Ingredient ID: NPC223695
Ingredient ID: NPC213563
Ingredient ID: NPC198007
Ingredient ID: NPC189768
Ingredient ID: NPC179694
Ingredient ID: NPC167072
Ingredient ID: NPC15494
Ingredient ID: NPC15118
Ingredient ID: NPC145911
Ingredient ID: NPC142673
Ingredient ID: NPC136434
Ingredient ID: NPC133856
Ingredient ID: NPC123965
Ingredient ID: NPC113691
Ingredient ID: NPC110257
Ingredient ID: NPC101888
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials |
|---|
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
