Plant ID: NPO27623
Plant Latin Name: Citrus Japonica
Taxonomy Genus: Citrus
Taxonomy Family: Rutaceae
NCBI TaxonomyDB:
76966
Plant-of-the-World-Online:
n.a.
India
Ingredient ID: NPC94355
Ingredient ID: NPC90336
Ingredient ID: NPC8587
Ingredient ID: NPC82295
Ingredient ID: NPC73422
Ingredient ID: NPC69127
Ingredient ID: NPC62392
Ingredient ID: NPC40818
Ingredient ID: NPC295219
Ingredient ID: NPC281034
Ingredient ID: NPC273340
Ingredient ID: NPC265319
Ingredient ID: NPC263955
Ingredient ID: NPC261195
Ingredient ID: NPC239350
Ingredient ID: NPC23593
Ingredient ID: NPC22062
Ingredient ID: NPC184607
Ingredient ID: NPC169575
Ingredient ID: NPC167667
Ingredient ID: NPC164843
Ingredient ID: NPC164490
Ingredient ID: NPC161520
Ingredient ID: NPC142860
Ingredient ID: NPC136275
Ingredient ID: NPC13625
Ingredient ID: NPC110639
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Hydrolase | EIF4A1 | Eukaryotic initiation factor 4A-I | P60842 | CHEMBL2052028 |
Therapeutic Target | Nuclear hormone receptor subfamily 1 | THRB | Thyroid hormone receptor beta-1 | P10828 | CHEMBL1947 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials |
---|
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
EIF4A1,THRB
|
Hypo-thyroidismDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A00 |
THRB
|
Inborn lipid metabolism errorDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C52 |
THRB
|
Hyper-lipoproteinaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
THRB
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
THRB
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
EIF4A1
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
EIF4A1
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
THRB
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
EIF4A1
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
THRB
|