Collective Molecular Activities of the Plant: Carpesium Abrotanoides
Unknown.
Turkey; Afghanistan; Italy; Nepal; Georgia; Laos; Australia; Iran; China; Belgium; Germany; Iraq; Kazakhstan; Netherlands; Poland; Vietnam; Japan; Switzerland; Russia; Bulgaria; Myanmar; South Africa; India; Austria; Greece; Hungary; Taiwan
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
35 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
21 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
12 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC90014
Ingredient ID: NPC7568
Ingredient ID: NPC72823
Ingredient ID: NPC69989
Ingredient ID: NPC59031
Ingredient ID: NPC56593
Ingredient ID: NPC47946
Ingredient ID: NPC473155
Ingredient ID: NPC470012
Ingredient ID: NPC45718
Ingredient ID: NPC36646
Ingredient ID: NPC329392
Ingredient ID: NPC328788
Ingredient ID: NPC325867
Ingredient ID: NPC308445
Ingredient ID: NPC305327
Ingredient ID: NPC304909
Ingredient ID: NPC277693
Ingredient ID: NPC27056
Ingredient ID: NPC260488
Ingredient ID: NPC253056
Ingredient ID: NPC239039
Ingredient ID: NPC226559
Ingredient ID: NPC219011
Ingredient ID: NPC216092
Ingredient ID: NPC206142
Ingredient ID: NPC205551
Ingredient ID: NPC203486
Ingredient ID: NPC202189
Ingredient ID: NPC196776
Ingredient ID: NPC178638
Ingredient ID: NPC175074
Ingredient ID: NPC138647
Ingredient ID: NPC12452
Ingredient ID: NPC122398
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Enzyme | UMPS | Uridine 5'-monophosphate synthase | P11172 | CHEMBL5216 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials |
|---|
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
UMPS
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
UMPS
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
UMPS
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
UMPS
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
UMPS
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
