Collective Molecular Activities of the Plant: Ricinus Communis
Plant ID: NPO24560
Plant Latin Name: Ricinus Communis
Taxonomy Genus: Ricinus
Taxonomy Family: Euphorbiaceae
Plant External Links:
NCBI TaxonomyDB:
3988
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
52 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
35 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
20 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99901
Ingredient ID: NPC87463
Ingredient ID: NPC83987
Ingredient ID: NPC78625
Ingredient ID: NPC77294
Ingredient ID: NPC65350
Ingredient ID: NPC61248
Ingredient ID: NPC60523
Ingredient ID: NPC485242
Ingredient ID: NPC43696
Ingredient ID: NPC304309
Ingredient ID: NPC291545
Ingredient ID: NPC283316
Ingredient ID: NPC2728
Ingredient ID: NPC269077
Ingredient ID: NPC268826
Ingredient ID: NPC267499
Ingredient ID: NPC265800
Ingredient ID: NPC264083
Ingredient ID: NPC253303
Ingredient ID: NPC249980
Ingredient ID: NPC244118
Ingredient ID: NPC243532
Ingredient ID: NPC243293
Ingredient ID: NPC238379
Ingredient ID: NPC230861
Ingredient ID: NPC22293
Ingredient ID: NPC21806
Ingredient ID: NPC212911
Ingredient ID: NPC208590
Ingredient ID: NPC208198
Ingredient ID: NPC202967
Ingredient ID: NPC192858
Ingredient ID: NPC185538
Ingredient ID: NPC179694
Ingredient ID: NPC175190
Ingredient ID: NPC173265
Ingredient ID: NPC171064
Ingredient ID: NPC16511
Ingredient ID: NPC161956
Ingredient ID: NPC161193
Ingredient ID: NPC161159
Ingredient ID: NPC157192
Ingredient ID: NPC135642
Ingredient ID: NPC134782
Ingredient ID: NPC128409
Ingredient ID: NPC121051
Ingredient ID: NPC118968
Ingredient ID: NPC113763
Ingredient ID: NPC113733
Ingredient ID: NPC106770
Ingredient ID: NPC101888
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials |
|---|
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
NAPRT
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❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
