Collective Molecular Activities of the Plant: Camellia Saluenensis
Plant ID: NPO23768
Plant Latin Name: Camellia Saluenensis
Taxonomy Genus: Camellia
Taxonomy Family: Theaceae
Plant External Links:
NCBI TaxonomyDB:
319929
Plant-of-the-World-Online:
n.a.
Country/Region:
ChinaTraditional Medicine System:
TCMChina
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
38 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
36 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
29 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC94637
Ingredient ID: NPC88839
Ingredient ID: NPC88566
Ingredient ID: NPC8416
Ingredient ID: NPC78500
Ingredient ID: NPC72258
Ingredient ID: NPC61665
Ingredient ID: NPC52403
Ingredient ID: NPC49151
Ingredient ID: NPC33489
Ingredient ID: NPC303893
Ingredient ID: NPC301690
Ingredient ID: NPC301540
Ingredient ID: NPC295442
Ingredient ID: NPC287331
Ingredient ID: NPC287191
Ingredient ID: NPC286627
Ingredient ID: NPC279895
Ingredient ID: NPC279300
Ingredient ID: NPC266539
Ingredient ID: NPC266144
Ingredient ID: NPC257124
Ingredient ID: NPC255042
Ingredient ID: NPC250539
Ingredient ID: NPC235797
Ingredient ID: NPC234961
Ingredient ID: NPC230221
Ingredient ID: NPC226794
Ingredient ID: NPC223118
Ingredient ID: NPC211453
Ingredient ID: NPC197356
Ingredient ID: NPC190797
Ingredient ID: NPC178939
Ingredient ID: NPC163556
Ingredient ID: NPC147054
Ingredient ID: NPC123357
Ingredient ID: NPC108779
Ingredient ID: NPC108218
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Oxidoreductase | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Therapeutic Target | Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 5 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00080366 | Octanol to Treat Essential Tremor | essential tremor | Octanol (NPC163556) | NP level |
| NCT00001986 | 1-Octanol to Treat Essential Tremor | essential tremor | Octanol (NPC163556) | NP level |
| NCT00102596 | Clinical Trial Characterizing the Bioavailability of 1-Octanol in Adults With Ethanol-responsive Essential Tremor | essential tremor | Octanol (NPC163556) | NP level |
| NCT00016679 | 1-Octanol to Treat Essential Tremor | essential tremor | Octanol (NPC163556) | NP level |
| NCT01119534 | Comparative Efficacy of the Suppository Versus Guaiacol Suppository Versus Guaifenesin Syrup in Pediatric Patients With Cough Due the Infectious Origin | Cough | Eucalyptol (NPC287331) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
Essential tremor or related tremorsDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A04.1 |
NCT00080366,NCT00102596,NCT00001986,NCT00016679
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
ALDH1A1,TRPA1
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
TRPA1,TRPA1
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
MAPK1,TRPA1
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
MAPK1
|
Pancreatic cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
MAPK1
|
NeuropathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C0Z |
TRPA1
|
Substance abuseDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40 |
ALDH1A1
|
MelanomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
MAPK1
|
Upper respiratory tract disorderDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA0Z |
TRPA1
|
Arteries/arterioles disorderDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD52 |
MAPK1
|
CoughDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD12 |
NCT01119534
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
TRPA1
|
Osteoarthritis, unspecifiedDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA0Z |
TRPA1
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
TRPA1
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
TRPA1
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
TRPA1
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
TRPA1
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
TRPA1
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
TRPA1
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
ALDH1A1
|
Pneumonia due to PseudomonasaeruginosaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA40.05 |
TRPA1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
TRPA1
|
Parkinson diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00.0 |
ALDH1A1
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
TRPA1
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
TRPA1
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
TRPA1
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
