CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Euphorbia Characias Subsp. Wulfenii

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO19668.1
Plant Latin Name: Euphorbia Characias Subsp. Wulfenii
Taxonomy Genus: Euphorbia
Taxonomy Family: Euphorbiaceae

Plant External Links:

NCBI TaxonomyDB: 3991
Plant-of-the-World-Online: 346016-1

Used in Medicines

Country/Region:

Italy; Spain

Traditional Medicine System:

Geographical Distribution

Turkey; Albania; Italy; Portugal; Libya; France; Morocco; Greece; Argentina; New Zealand; Spain

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

30 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

22 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

15 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC76884

Ingredient ID: NPC73492

Ingredient ID: NPC63646

Ingredient ID: NPC55470

Ingredient ID: NPC49075

Ingredient ID: NPC47721

Ingredient ID: NPC313133

Ingredient ID: NPC298979

Ingredient ID: NPC293624

Ingredient ID: NPC290582

Ingredient ID: NPC279533

Ingredient ID: NPC278525

Ingredient ID: NPC252643

Ingredient ID: NPC249405

Ingredient ID: NPC232924

Ingredient ID: NPC231560

Ingredient ID: NPC22481

Ingredient ID: NPC217280

Ingredient ID: NPC205421

Ingredient ID: NPC196231

Ingredient ID: NPC173840

Ingredient ID: NPC166688

Ingredient ID: NPC146264

Ingredient ID: NPC145980

Ingredient ID: NPC142713

Ingredient ID: NPC141977

Ingredient ID: NPC128560

Ingredient ID: NPC127274

Ingredient ID: NPC123331

Ingredient ID: NPC118804

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Therapeutic Target	Other cytosolic protein	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Therapeutic Target	Small molecule receptor (family A GPCR)	ADRA1D	Alpha-1d adrenergic receptor	P25100	CHEMBL223
Therapeutic Target	Small molecule receptor (family A GPCR)	ADRA1A	Alpha-1a adrenergic receptor	P35348	CHEMBL229

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	1

Clinical trial details

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT05398705	Study of Oral High/Low-dose Cepharanthine Compared With Placebo in Non Hospitalized Adults With COVID-19	COVID-19	Cepharanthine (NPC73492)	NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant	Association Type & Detailed Evidence
Hepatocellular carcinoma of liver Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.02	MAPT,ADRA1D,MAPT
Pain, unspecified Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MG3Z	ADRA1A,ADRA1D
Pulmonary hypertension Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BB01	ADRA1A,ADRA1D
Mild neurocognitive disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6D71	ADRA1A,MAPT
Prostate hyperplasia Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA90	ADRA1D,ADRA1A
Glaucoma Disease Category: 09.Diseases of the visual system Disease ICD-11 Code: 9C61	ADRA1D
Prostate cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C82	ADRA1A
Sexual dysfunction Disease Category: 17.Conditions related to sexual health Disease ICD-11 Code: HA00-HA01	ADRA1D
Parkinsonism Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A00	MAPT
Acute myeloid leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A60	MAPT
Alzheimer disease Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A20	MAPT
Heart failure Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BD10-BD1Z	ADRA1D
Choreiform disorder Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A01	MAPT
Solid tumour/cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00-2F9Z	ADRA1D
COVID-19 Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D6Y	NCT05398705
Pheochromocytoma Disease Category: X.Extension Codes Disease ICD-11 Code: XH3854	MAPT
Malignant neoplasms of biliary tract, distal bile duct Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C15	MAPT
Hepatoblastoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.01	ADRA1D
Cytomegaloviral disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D82	ADRA1D
Chikungunya virus disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D40	ADRA1A
Malignant neoplasms of thymus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C27	MAPT

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Euphorbia Characias Subsp. Wulfenii

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

Country/Region:

Traditional Medicine System:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

30 All known Ingredients in Total

22 Ingredients with Acceptable Bioavailablity

15 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Hepatocellular carcinoma of liver

Pain, unspecified

Pulmonary hypertension

Mild neurocognitive disorder

Prostate hyperplasia

Glaucoma

Prostate cancer

Sexual dysfunction

Parkinsonism

Acute myeloid leukaemia

Alzheimer disease

Heart failure

Choreiform disorder

Solid tumour/cancer

COVID-19

Pheochromocytoma

Malignant neoplasms of biliary tract, distal bile duct

Hepatoblastoma

Cytomegaloviral disease

Chikungunya virus disease

Malignant neoplasms of thymus

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities