CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Calystegia Pubescens

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO15597
Plant Latin Name: Calystegia Pubescens
Taxonomy Genus: Calystegia
Taxonomy Family: Convolvulaceae

Plant External Links:

NCBI TaxonomyDB: 649339
Plant-of-the-World-Online: n.a.

Used in Medicines

Unknown.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

83 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

55 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

27 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC9874

Ingredient ID: NPC92615

Ingredient ID: NPC90982

Ingredient ID: NPC90757

Ingredient ID: NPC89

Ingredient ID: NPC88806

Ingredient ID: NPC87213

Ingredient ID: NPC86438

Ingredient ID: NPC86249

Ingredient ID: NPC81803

Ingredient ID: NPC81010

Ingredient ID: NPC81002

Ingredient ID: NPC80600

Ingredient ID: NPC76356

Ingredient ID: NPC74351

Ingredient ID: NPC70744

Ingredient ID: NPC6984

Ingredient ID: NPC63973

Ingredient ID: NPC61461

Ingredient ID: NPC5586

Ingredient ID: NPC51570

Ingredient ID: NPC47094

Ingredient ID: NPC37468

Ingredient ID: NPC32163

Ingredient ID: NPC311986

Ingredient ID: NPC309557

Ingredient ID: NPC306244

Ingredient ID: NPC303409

Ingredient ID: NPC301377

Ingredient ID: NPC300017

Ingredient ID: NPC29883

Ingredient ID: NPC296427

Ingredient ID: NPC294470

Ingredient ID: NPC291454

Ingredient ID: NPC28983

Ingredient ID: NPC287992

Ingredient ID: NPC287301

Ingredient ID: NPC280077

Ingredient ID: NPC276808

Ingredient ID: NPC276268

Ingredient ID: NPC273070

Ingredient ID: NPC272695

Ingredient ID: NPC272537

Ingredient ID: NPC272415

Ingredient ID: NPC265007

Ingredient ID: NPC263417

Ingredient ID: NPC263367

Ingredient ID: NPC258546

Ingredient ID: NPC251102

Ingredient ID: NPC248355

Ingredient ID: NPC245561

Ingredient ID: NPC24402

Ingredient ID: NPC241105

Ingredient ID: NPC235431

Ingredient ID: NPC228346

Ingredient ID: NPC227698

Ingredient ID: NPC227678

Ingredient ID: NPC227302

Ingredient ID: NPC219913

Ingredient ID: NPC212770

Ingredient ID: NPC205796

Ingredient ID: NPC205054

Ingredient ID: NPC203719

Ingredient ID: NPC202472

Ingredient ID: NPC199194

Ingredient ID: NPC194416

Ingredient ID: NPC192612

Ingredient ID: NPC186418

Ingredient ID: NPC176015

Ingredient ID: NPC171721

Ingredient ID: NPC170807

Ingredient ID: NPC160345

Ingredient ID: NPC156654

Ingredient ID: NPC156502

Ingredient ID: NPC155930

Ingredient ID: NPC150919

Ingredient ID: NPC147583

Ingredient ID: NPC141799

Ingredient ID: NPC140201

Ingredient ID: NPC130833

Ingredient ID: NPC130754

Ingredient ID: NPC111888

Ingredient ID: NPC111625

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Therapeutic Target	Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Therapeutic Target	Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Therapeutic Target	Small molecule receptor (family A GPCR)	DRD1	Dopamine D1 receptor	P21728	CHEMBL2056
Therapeutic Target	Unclassified protein	SNCA	Alpha-synuclein	P37840	CHEMBL6152

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	4

Clinical trial details

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT00992667	Inhaled Apocynin Decreases Reactive Oxygen Species Concentrations in Exhaled Breath Condensate in Mild Asthmatics	asthma	Apocynin (NPC32163)	NP level
NCT01402297	Hydrogen Peroxide and Nitrite Reduction in Exhaled Breath Condensate of COPD Patients	chronic obstructive pulmonary disease	Apocynin (NPC32163)	NP level
NCT03680638	The Effect of Antioxidants on Skin Blood Flow During Local Heating	cardiovascular disease	Apocynin (NPC32163)	NP level
NCT03680573	The Effect of Antioxidants on Skin Blood Flow-BH4	cardiovascular disease	Apocynin (NPC32163)	NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant	Association Type & Detailed Evidence
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	SNCA,CA14,DRD1,CA2
Germ cell tumour of testis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C80.2	SNCA,CA14,DRD1,AKR1B1
Carcinosarcoma of uterus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.43	CA14,CA2,AKR1B1
Pheochromocytoma Disease Category: X.Extension Codes Disease ICD-11 Code: XH3854	SNCA,CA14,CA2
Malignant neoplasms of thymus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C27	TRIM24,DRD1,AKR1B1
Rheumatoid arthritis Disease Category: 15.Diseases of the musculoskeletal system or connective tissue Disease ICD-11 Code: FA20	AKR1B1,CA2
Schizophrenia Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A20	DRD1,AKR1B1
Solid tumour/cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00-2F9Z	CA14,CA2
Parkinsonism Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A00	DRD1,SNCA
Breast cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C60-2C6Y	CA14,CA2
Bacterial infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1A00-1C4Z	CA14,CA2
Glaucoma Disease Category: 09.Diseases of the visual system Disease ICD-11 Code: 9C61	AKR1B1,CA2
Cardiovascular disease Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA00-BE2Z	NCT03680573,NCT03680638
Hepatoblastoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.01	TRIM24,AKR1B1
Diffuse large B-cell lymphomas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A81	TRIM24,AKR1B1
Mesothelioma of pleura Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C26.0	SNCA,DRD1
Superficial ovarian endometriosis Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA10.B4	SNCA,CA2
Urothelial carcinoma of bladder Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C94.2	CA2,AKR1B1
Cytomegaloviral disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D82	CA14,CA2
Acute diabete complication Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A2Y	AKR1B1
Allergic/hypersensitivity disorder Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4A80-4A8Z	DRD1
Psychotic disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A20-6A25	DRD1
Heart failure Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BD10-BD1Z	CA2
Neuropathy Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C0Z	AKR1B1
Tic disorder Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A05	DRD1
Inborn metabolism deficiency Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C50-5C59	CA14
Pain, unspecified Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MG3Z	AKR1B1
Alzheimer disease Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A20	SNCA
Insomnia Disease Category: 07.Sleep-wake disorders Disease ICD-11 Code: 7A00-7A0Z	CA2
Autonomic nervous system disorder Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8D87	SNCA
Cocaine use disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6C45	DRD1
Dementia Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6D80-6D8Z	DRD1
Duodenal ulcer Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DA63	CA2
Pulmonary hypertension Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BB01	DRD1
Seborrhoeic dermatitis Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA81	CA2
Cataract Disease Category: 09.Diseases of the visual system Disease ICD-11 Code: 9B10	AKR1B1
Abortion Disease Category: 18.Pregnancy, childbirth or the puerperium Disease ICD-11 Code: JA00	DRD1
Essential hypertension Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA00	CA2
Thrombosis Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB61-GB90	AKR1B1
Low bone mass disorder Disease Category: 15.Diseases of the musculoskeletal system or connective tissue Disease ICD-11 Code: FB83	CA2
Asthma Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA23	NCT00992667
Chronic obstructive pulmonary disease Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA22	NCT01402297
Serous cystadenoma,borderline malignancy of ovary Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C73.4	CA2
Malignant neoplasms of biliary tract, distal bile duct Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C15	AKR1B1
Leishmaniasis Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F54	AKR1B1
Adenocarcinoma of stomach Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72.0	DRD1
Tetralogy of Fallot Disease Category: 20.Developmental anomalies Disease ICD-11 Code: LA88.2	CA14
Hepatocellular carcinoma of liver Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.02	TRIM24
Malignant neoplasms of corpus uteri, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.Z	CA2
Glioblastoma of brain Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00.00	CA2
Renal cell carcinoma, chromophobe type Disease Category: X.Extension Codes Disease ICD-11 Code: XH6153	CA2
Malignant neoplasms of adrenal gland Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D11	SNCA

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Calystegia Pubescens

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

83 All known Ingredients in Total

55 Ingredients with Acceptable Bioavailablity

27 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Adenocarcinoma of pancreas

Germ cell tumour of testis

Carcinosarcoma of uterus

Pheochromocytoma

Malignant neoplasms of thymus

Rheumatoid arthritis

Schizophrenia

Solid tumour/cancer

Parkinsonism

Breast cancer

Bacterial infection

Glaucoma

Cardiovascular disease

Hepatoblastoma

Diffuse large B-cell lymphomas

Mesothelioma of pleura

Superficial ovarian endometriosis

Urothelial carcinoma of bladder

Cytomegaloviral disease

Acute diabete complication

Allergic/hypersensitivity disorder

Psychotic disorder

Heart failure

Neuropathy

Tic disorder

Inborn metabolism deficiency

Pain, unspecified

Alzheimer disease

Insomnia

Autonomic nervous system disorder

Cocaine use disorder

Dementia

Duodenal ulcer

Pulmonary hypertension

Seborrhoeic dermatitis

Cataract

Abortion

Essential hypertension

Thrombosis

Low bone mass disorder

Asthma

Chronic obstructive pulmonary disease

Serous cystadenoma,borderline malignancy of ovary

Malignant neoplasms of biliary tract, distal bile duct

Leishmaniasis

Adenocarcinoma of stomach

Tetralogy of Fallot

Hepatocellular carcinoma of liver

Malignant neoplasms of corpus uteri, unspecified

Glioblastoma of brain

Renal cell carcinoma, chromophobe type

Malignant neoplasms of adrenal gland

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities