Collective Molecular Activities of the Plant: Alnus Japonica
Country/Region:
South KoreaTraditional Medicine System:
Medicinal Functions:
Cancer
South Africa; Russia; China; Japan; South Korea; Taiwan
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
50 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
31 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
28 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC836
Ingredient ID: NPC7686
Ingredient ID: NPC75039
Ingredient ID: NPC64765
Ingredient ID: NPC61062
Ingredient ID: NPC476407
Ingredient ID: NPC473138
Ingredient ID: NPC473137
Ingredient ID: NPC473136
Ingredient ID: NPC40258
Ingredient ID: NPC37033
Ingredient ID: NPC34634
Ingredient ID: NPC324467
Ingredient ID: NPC321194
Ingredient ID: NPC311259
Ingredient ID: NPC305074
Ingredient ID: NPC29989
Ingredient ID: NPC296697
Ingredient ID: NPC293686
Ingredient ID: NPC290598
Ingredient ID: NPC28776
Ingredient ID: NPC286222
Ingredient ID: NPC27765
Ingredient ID: NPC266441
Ingredient ID: NPC265800
Ingredient ID: NPC230047
Ingredient ID: NPC223579
Ingredient ID: NPC223253
Ingredient ID: NPC206812
Ingredient ID: NPC203891
Ingredient ID: NPC193018
Ingredient ID: NPC182240
Ingredient ID: NPC180171
Ingredient ID: NPC17968
Ingredient ID: NPC177576
Ingredient ID: NPC176607
Ingredient ID: NPC173638
Ingredient ID: NPC158673
Ingredient ID: NPC158325
Ingredient ID: NPC156116
Ingredient ID: NPC145379
Ingredient ID: NPC143863
Ingredient ID: NPC139901
Ingredient ID: NPC131532
Ingredient ID: NPC122318
Ingredient ID: NPC121817
Ingredient ID: NPC121372
Ingredient ID: NPC106364
Ingredient ID: NPC103398
Ingredient ID: NPC102803
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Nuclear hormone receptor subfamily 1 | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials |
|---|
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
