Plant ID: NPO12595
Plant Latin Name: Euphorbia Royleana
Taxonomy Genus: Euphorbia
Taxonomy Family: Euphorbiaceae
NCBI TaxonomyDB:
1130020
Plant-of-the-World-Online:
n.a.
India; China
Ingredient ID: NPC94196
Ingredient ID: NPC8505
Ingredient ID: NPC82623
Ingredient ID: NPC76336
Ingredient ID: NPC74236
Ingredient ID: NPC479266
Ingredient ID: NPC479265
Ingredient ID: NPC479264
Ingredient ID: NPC479263
Ingredient ID: NPC479261
Ingredient ID: NPC479260
Ingredient ID: NPC479259
Ingredient ID: NPC479258
Ingredient ID: NPC479257
Ingredient ID: NPC479256
Ingredient ID: NPC479255
Ingredient ID: NPC479254
Ingredient ID: NPC479253
Ingredient ID: NPC479252
Ingredient ID: NPC479249
Ingredient ID: NPC477103
Ingredient ID: NPC477102
Ingredient ID: NPC477101
Ingredient ID: NPC477100
Ingredient ID: NPC477099
Ingredient ID: NPC477098
Ingredient ID: NPC477097
Ingredient ID: NPC477096
Ingredient ID: NPC477095
Ingredient ID: NPC477094
Ingredient ID: NPC477093
Ingredient ID: NPC477092
Ingredient ID: NPC46160
Ingredient ID: NPC45255
Ingredient ID: NPC42577
Ingredient ID: NPC40209
Ingredient ID: NPC327873
Ingredient ID: NPC325560
Ingredient ID: NPC321194
Ingredient ID: NPC29922
Ingredient ID: NPC29905
Ingredient ID: NPC296697
Ingredient ID: NPC289664
Ingredient ID: NPC28657
Ingredient ID: NPC265800
Ingredient ID: NPC25212
Ingredient ID: NPC251616
Ingredient ID: NPC216630
Ingredient ID: NPC196776
Ingredient ID: NPC19082
Ingredient ID: NPC169468
Ingredient ID: NPC16345
Ingredient ID: NPC154346
Ingredient ID: NPC151844
Ingredient ID: NPC147923
Ingredient ID: NPC131182
Ingredient ID: NPC118508
Ingredient ID: NPC106364
Ingredient ID: NPC101352
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Fatty acid binding protein family | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
Therapeutic Target | Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
Therapeutic Target | Nuclear hormone receptor subfamily 1 | RORC | Nuclear receptor ROR-gamma | P51449 | CHEMBL1741186 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 4 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT00965068 | Cholesterol in ASD: Characterization and Treatment | Asperger syndrome;autism | Cholesterol (NPC28657) | NP level |
NCT00272844 | Treatment of the Cholesterol Defect in Smith-Lemli-Opitz Syndrome | Smith-Lemli-Opitz syndrome | Cholesterol (NPC28657) | NP level |
NCT04359823 | DSAP Treatment Comparison | porokeratosis | Cholesterol (NPC28657) | NP level |
NCT00009841 | Gene Therapy in Treating Patients With Advanced Head and Neck Cancer | head and neck malignant neoplasia | Cholesterol (NPC28657) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
FABP5,CA9,FABP5,CA9,OR51E2
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
FABP5,CA9,FABP4,OR51E2,CA9
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
CA9,FABP4,OR51E2,FABP5
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
FABP5,CA9,RORC
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
CA9,RORC,FABP5
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
FABP5,RORC,OR51E2
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
FABP5,CA9,OR51E2
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
FABP5,FABP4,OR51E2
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
FABP5,CA9,OR51E2
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
RORC,CA9
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
RORC
FABP5 |
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
CA9,FABP4
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
CA9,OR51E2
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CA9,OR51E2
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
CA9,OR51E2
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
FABP5,OR51E2
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
FABP5,CA9
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
FABP5,CA9
|
Autoimmune diseaseDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40-4A45 |
RORC
|
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
RORC
|
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
RORC
|
Mature T-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A90 |
CA9
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
RORC
|
Renal cell carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90 |
CA9
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
CA9
|
Autism spectrum disorder without disorder of intellectual development and with mild or no impairment of functional languageDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A02.0 |
NCT00965068
|
Autism spectrum disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A02 |
NCT00965068
|
Head and neck cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D42 |
NCT00009841
|
Disorders of cholesterol synthesisDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C52.10 |
NCT00272844
|
PorokeratosesDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED52 |
NCT04359823
|
Non-alcoholic fatty liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB92 |
FABP4
|
Malignant neoplasms of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94 |
FABP4
|
Tetralogy of FallotDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA88.2 |
RORC
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
CA9
|
Other specified malignant neoplasms of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.Y |
CA9
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
CA9
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
KDM4E
|
Systemic sclerosisDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A42 |
FABP4
|
Chronic rhinosinusitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA0A |
CA9
|
Malignant neoplasms of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
FABP4
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA9
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
CA9
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
CA9
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
FABP5
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
OR51E2
|
Malignant neoplasm of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
FABP4
|