CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Echinops Grijsii

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO11329
Plant Latin Name: Echinops Grijsii
Taxonomy Genus: Echinops
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 1804979
Plant-of-the-World-Online: 202515-1

Used in Medicines

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution

Taiwan; China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

52 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

28 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

11 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC88759

Ingredient ID: NPC85813

Ingredient ID: NPC76145

Ingredient ID: NPC6850

Ingredient ID: NPC66943

Ingredient ID: NPC60427

Ingredient ID: NPC59570

Ingredient ID: NPC46170

Ingredient ID: NPC45270

Ingredient ID: NPC34764

Ingredient ID: NPC34125

Ingredient ID: NPC323806

Ingredient ID: NPC323787

Ingredient ID: NPC323434

Ingredient ID: NPC320738

Ingredient ID: NPC309606

Ingredient ID: NPC307063

Ingredient ID: NPC299720

Ingredient ID: NPC298091

Ingredient ID: NPC291724

Ingredient ID: NPC29082

Ingredient ID: NPC290732

Ingredient ID: NPC288932

Ingredient ID: NPC278072

Ingredient ID: NPC271027

Ingredient ID: NPC258000

Ingredient ID: NPC257035

Ingredient ID: NPC25407

Ingredient ID: NPC250166

Ingredient ID: NPC249045

Ingredient ID: NPC248271

Ingredient ID: NPC247042

Ingredient ID: NPC234846

Ingredient ID: NPC220089

Ingredient ID: NPC216630

Ingredient ID: NPC215717

Ingredient ID: NPC204759

Ingredient ID: NPC203634

Ingredient ID: NPC186653

Ingredient ID: NPC180880

Ingredient ID: NPC159754

Ingredient ID: NPC157017

Ingredient ID: NPC156205

Ingredient ID: NPC155182

Ingredient ID: NPC150643

Ingredient ID: NPC14917

Ingredient ID: NPC142753

Ingredient ID: NPC128915

Ingredient ID: NPC117416

Ingredient ID: NPC116696

Ingredient ID: NPC108872

Ingredient ID: NPC10251

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Therapeutic Target	Enzyme	AKR1C3	Aldo-keto-reductase family 1 member C3	P42330	CHEMBL4681
Therapeutic Target	Fatty acid binding protein family	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Therapeutic Target	Nuclear hormone receptor subfamily 1	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Therapeutic Target	Oxidoreductase	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Therapeutic Target	Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Therapeutic Target	Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Therapeutic Target	Structural protein	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	8

Clinical trial details

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT04392622	d-Limonene +Radiation +Platinum Based Chemo for Xerostomia Prevention in Locally Advanced Head and Neck Squamous Cell Carcinoma	xerostomia	Limonene (NPC76145)	NP level
NCT02063802	Metformin vs Conjugated Linoleic Acid and an Intervention Program With Healthy Habits in Obese Children	obesity	Linoleic Acid (NPC85813)	NP level
NCT00908791	Proof of Principle Trial to Determine if Nutritional Supplement Conjugated Linoleic Acid (CLA) Can Modulate the Lipogenic Pathway in Breast Cancer Tissue	breast cancer	Linoleic Acid (NPC85813)	NP level
NCT04853082	Limonene on Regulating Metabolism-related Fatty Liver Disease (MAFLD) and Analysis of TCM Constitution	Hepatic steatosis	Limonene (NPC76145)	NP level
NCT00029679	Borage Oil and Ginkgo Biloba (EGb 761) in Asthma	asthma	Linoleic Acid (NPC85813)	NP level
NCT00607945	Dietary Fatty Acids as Complementary Therapy in Type 2 Diabetes Mellitus	type 2 diabetes mellitus	Linoleic Acid (NPC85813)	NP level
NCT00204932	Effects of CLA Supplements on Body Weight and Fat Oxidation	obesity	Linoleic Acid (NPC85813)	NP level
NCT00951158	A Molecular Pharmacodynamic Dose-titration Trial of Conjugated Linoleic Acid (CLA; Clarinol®) in Patients With Advanced Solid Tumors	neoplasm	Linoleic Acid (NPC85813)	NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant	Association Type & Detailed Evidence
Diffuse large B-cell lymphomas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A81	LMNA,OR51E2,FABP4,FABP5,FABP3,FFAR1
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	LMNA,AKR1C3,OR51E2,ALOX15,FFAR4,FABP3
Other specified malignant neoplasms of kidney, except renal pelvis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C90.Y	FFAR4,FABP5,FFAR4,OR51E2,FABP5
Mesothelioma of pleura Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C26.0	LMNA,OR51E2,ALOX15,FFAR4,FFAR1
Hepatocellular carcinoma of liver Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.02	FABP5,OR51E2,AKR1C3,FABP4,AKR1C3
Carcinosarcoma of uterus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.43	FABP5,ALOX15,FFAR4,FFAR1
Serous cystadenoma,borderline malignancy of ovary Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C73.4	FABP5,ALOX15,FFAR4,FABP3
Hepatoblastoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.01	FABP5,FABP3,OR51E2,FABP4
Malignant neoplasms of adrenal gland Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D11	FFAR1,FABP3,OR51E2,FABP5
Malignant neoplasms of biliary tract, distal bile duct Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C15	LMNA,OR51E2,FABP5
Adenocarcinoma of prostate Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C82.0	ALOX15,OR51E2,FABP5
Malignant neoplasms of thymus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C27	FABP5,ALOX15,FFAR4
Type 2 diabetes mellitus Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A11	FFAR1 NCT00607945
Obesity Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5B80-5B81	NCT00204932,NCT02063802
Pheochromocytoma Disease Category: X.Extension Codes Disease ICD-11 Code: XH3854	OR51E2,FABP5
Malignant neoplasm metastasis in lymph nodes of head, face or neck Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D60.0	AKR1C3,FABP4
Squamous cell carcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.2	AKR1C3,OR51E2
Melanoma of skin Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C30	FFAR1,FABP3
Superficial ovarian endometriosis Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA10.B4	FABP3,LMNA
Chikungunya virus disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D40	LMNA,FFAR1
Glioblastoma of brain Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00.00	LMNA,FABP5
Germ cell tumour of testis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C80.2	FABP5,FABP3
Carpal tunnel syndrome Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C10.0	FFAR4,OR51E2
Idiopathic interstitial pneumonitis Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CB03	FFAR1
Female pelvic pain Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA34	AKR1C3
Prostate cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C82	AKR1C3
Acute diabete complication Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A2Y	FFAR1
Other specified non-alcoholic fatty liver disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB92.Y	NCT04853082
Asthma Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA23	NCT00029679
Breast cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C60-2C6Y	NCT00908791
Xerostomia Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DA02.1	NCT04392622
Neoplasms Disease Category: 02.Neoplasms Disease ICD-11 Code: 02	NCT00951158
Psoriasis Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA90	FABP5
Adenocarcinoma of stomach Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72.0	ALOX15
Non-alcoholic fatty liver disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB92	FABP4
Malignant neoplasms of bladder Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C94	FABP4
Other specified malignant neoplasms of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.Y	AKR1C3
Malignant neoplasms of oesophagus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B70	ALOX15
Cytomegaloviral disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D82	ALOX15
Systemic sclerosis Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4A42	FABP4
Systemic lupus erythematosus Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4A40.0	FFAR1
Malignant neoplasms of thyroid gland, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D10.Z	FFAR1
Malignant neoplasms of stomach Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72	FABP4
Adenocarcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.0	AKR1C3
Malignant neoplasms of corpus uteri, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.Z	ALOX15
Polycystic ovary syndrome Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A80.1	FFAR4
Human immunodeficiency virus disease without mention of tuberculosis or malaria Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1C62	FFAR1
Malignant neoplasm of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10	FABP4
Gliomas of brain Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00.0	AKR1C3

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Echinops Grijsii

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

Country/Region:

Traditional Medicine System:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

52 All known Ingredients in Total

28 Ingredients with Acceptable Bioavailablity

11 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Diffuse large B-cell lymphomas

Adenocarcinoma of pancreas

Other specified malignant neoplasms of kidney, except renal pelvis

Mesothelioma of pleura

Hepatocellular carcinoma of liver

Carcinosarcoma of uterus

Serous cystadenoma,borderline malignancy of ovary

Hepatoblastoma

Malignant neoplasms of adrenal gland

Malignant neoplasms of biliary tract, distal bile duct

Adenocarcinoma of prostate

Malignant neoplasms of thymus

Type 2 diabetes mellitus

Obesity

Pheochromocytoma

Malignant neoplasm metastasis in lymph nodes of head, face or neck

Squamous cell carcinoma of bronchus or lung

Melanoma of skin

Superficial ovarian endometriosis

Chikungunya virus disease

Glioblastoma of brain

Germ cell tumour of testis

Carpal tunnel syndrome

Idiopathic interstitial pneumonitis

Female pelvic pain

Prostate cancer

Acute diabete complication

Other specified non-alcoholic fatty liver disease

Asthma

Breast cancer

Xerostomia

Neoplasms

Psoriasis

Adenocarcinoma of stomach

Non-alcoholic fatty liver disease

Malignant neoplasms of bladder

Other specified malignant neoplasms of bronchus or lung

Malignant neoplasms of oesophagus

Cytomegaloviral disease

Systemic sclerosis

Systemic lupus erythematosus

Malignant neoplasms of thyroid gland, unspecified

Malignant neoplasms of stomach

Adenocarcinoma of bronchus or lung

Malignant neoplasms of corpus uteri, unspecified

Polycystic ovary syndrome

Human immunodeficiency virus disease without mention of tuberculosis or malaria

Malignant neoplasm of pancreas

Gliomas of brain

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities