Collective Molecular Activities of the Plant: Vincetoxicum Stauntonii
Plant ID: NPO10366
Plant Latin Name: Vincetoxicum Stauntonii
Taxonomy Genus: Vincetoxicum
Taxonomy Family: Apocynaceae
Plant External Links:
NCBI TaxonomyDB:
516547
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
66 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
48 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
29 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC96218
Ingredient ID: NPC90566
Ingredient ID: NPC90232
Ingredient ID: NPC88759
Ingredient ID: NPC86906
Ingredient ID: NPC79456
Ingredient ID: NPC79238
Ingredient ID: NPC7491
Ingredient ID: NPC74308
Ingredient ID: NPC7214
Ingredient ID: NPC71621
Ingredient ID: NPC68889
Ingredient ID: NPC64370
Ingredient ID: NPC60556
Ingredient ID: NPC5555
Ingredient ID: NPC49151
Ingredient ID: NPC41348
Ingredient ID: NPC38216
Ingredient ID: NPC36783
Ingredient ID: NPC309182
Ingredient ID: NPC308749
Ingredient ID: NPC304208
Ingredient ID: NPC301585
Ingredient ID: NPC28779
Ingredient ID: NPC283277
Ingredient ID: NPC282694
Ingredient ID: NPC278683
Ingredient ID: NPC273385
Ingredient ID: NPC272592
Ingredient ID: NPC256989
Ingredient ID: NPC244582
Ingredient ID: NPC239406
Ingredient ID: NPC236579
Ingredient ID: NPC233533
Ingredient ID: NPC231738
Ingredient ID: NPC223455
Ingredient ID: NPC222591
Ingredient ID: NPC21664
Ingredient ID: NPC209275
Ingredient ID: NPC208936
Ingredient ID: NPC198654
Ingredient ID: NPC197978
Ingredient ID: NPC191123
Ingredient ID: NPC186098
Ingredient ID: NPC1838
Ingredient ID: NPC175987
Ingredient ID: NPC171175
Ingredient ID: NPC163556
Ingredient ID: NPC16157
Ingredient ID: NPC161374
Ingredient ID: NPC161162
Ingredient ID: NPC161097
Ingredient ID: NPC154477
Ingredient ID: NPC152405
Ingredient ID: NPC151843
Ingredient ID: NPC144682
Ingredient ID: NPC13789
Ingredient ID: NPC134025
Ingredient ID: NPC12845
Ingredient ID: NPC127122
Ingredient ID: NPC118329
Ingredient ID: NPC110615
Ingredient ID: NPC109813
Ingredient ID: NPC106250
Ingredient ID: NPC105329
Ingredient ID: NPC101285
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Therapeutic Target | Methyl-lysine/arginine binding protein | SMN1 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADRA2C | Alpha-2c adrenergic receptor | P18825 | CHEMBL1916 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | HRH3 | Histamine H3 receptor | Q9Y5N1 | CHEMBL264 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | CNR2 | Cannabinoid CB2 receptor | P34972 | CHEMBL253 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADRA2A | Alpha-2a adrenergic receptor | P08913 | CHEMBL1867 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 7 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT02220673 | Serial Lung Function Measurements in Healthy and Mild Asthmatic Adults After Oral Inhalation of Ethanolic Solutions Containing Two Concentrations of the Excipient Butylated Hydroxytoluene (BHT) Administered With the Respimat® B (RMT-B) | asthma | Butylated Hydroxytoluene (NPC144682) | NP level |
| NCT00080366 | Octanol to Treat Essential Tremor | essential tremor | Octanol (NPC163556) | NP level |
| NCT00103974 | Immunotherapy With BHT-3009 Alone or Combined With Atorvastatin in Patients With Multiple Sclerosis | multiple sclerosis | Butylated Hydroxytoluene (NPC144682) | NP level |
| NCT00102596 | Clinical Trial Characterizing the Bioavailability of 1-Octanol in Adults With Ethanol-responsive Essential Tremor | essential tremor | Octanol (NPC163556) | NP level |
| NCT00001986 | 1-Octanol to Treat Essential Tremor | essential tremor | Octanol (NPC163556) | NP level |
| NCT00016679 | 1-Octanol to Treat Essential Tremor | essential tremor | Octanol (NPC163556) | NP level |
| NCT00382629 | BHT-3009 Immunotherapy in Relapsing Remitting Multiple Sclerosis | relapsing-remitting multiple sclerosis | Butylated Hydroxytoluene (NPC144682) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
Essential tremor or related tremorsDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A04.1 |
NCT00016679,NCT00102596,NCT00001986,NCT00080366
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
ADRA2A,ADRA2C,CNR2,SMN1
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
HRH3,CA2,ADRA2C,CNR2
|
Substance abuseDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40 |
ADRA2C,HRH3,ADRA2A
|
Attention deficit hyperactivity disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A05 |
ADRA2A,HRH3,CNR2
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
CNR2,ADRA2C,ADRA2A
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
HRH3,ADRA2A,CA2
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
ADRA2A,CNR2,SMN1
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
ADRA2C,CNR2,SMN1
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
HRH3,ADRA2A,ADRA2C
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
HRH3,ADRA2C
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
CA2,ADRA2C
|
Chronic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG30 |
HRH3,ADRA2C
|
Muscular atrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B61 |
SMN1,SMN2
|
Vasomotor/allergic rhinitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA08 |
HRH3,ADRA2C
|
InsomniaDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A00-7A0Z |
CNR2,CA2
|
General pain disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E43 |
ADRA2C,CNR2
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
HRH3,CA2
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
CA2,ADRA2C
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
ADRA2A,ADRA2C
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CA2,CNR2
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
ADRA2A,CA2
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
HRH3,CA2
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
ADRA2C,CNR2
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
HRH3,CNR2
|
DementiaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D80-6D8Z |
HRH3
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
CA2
|
Duodenal ulcerDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA63 |
CA2
|
DepressionDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A70-6A7Z |
ADRA2A
|
Chronic kidney diseaseDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB61 |
ADRA2C
|
NeuropathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C0Z |
HRH3
|
Inborn lipid metabolism errorDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C52 |
CNR2
|
SomnolenceDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG42 |
HRH3
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
CA2
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
CA2
|
Dissociative neurological symptom disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6B60 |
ADRA2C
|
Low bone mass disorderDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB83 |
CA2
|
Mild neurocognitive disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D71 |
HRH3
|
Seborrhoeic dermatitisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA81 |
CA2
|
Heart failureDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD10-BD1Z |
CA2
|
Sleep-wake disorderDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A00-7B2Z |
HRH3
|
Post-traumatic stress disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6B40 |
ADRA2C
|
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
ADRA2C
|
Pulmonary hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB01 |
ADRA2C
|
HypotensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA20-BA21 |
ADRA2C
|
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
HRH3
|
NarcolepsyDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A20 |
HRH3
|
Chronic arterial occlusive diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD4Z |
ADRA2C
|
Essential hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00 |
CA2
|
Non-specific cutaneous vascular symptonDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: ME64 |
ADRA2C
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
CA2
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
CNR2
|
Herpes simplex infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F00 |
ADRA2C
|
Opioid use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C43 |
ADRA2A
|
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
CNR2
|
Relapsing-remitting multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40.0 |
NCT00382629
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
NCT02220673
|
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
NCT00103974
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
ADRA2C
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
CNR2
|
Myotonic dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C71.0 |
ADRA2A
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
ADRA2C
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
CA2
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
ADRA2C
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
ADRA2A
|
Human immunodeficiency virus disease without mention of tuberculosis or malariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62 |
CNR2
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
CA2
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
CA2
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
