TDP1; RECQL; | |
ATR; | |
CA2; CA14; CA7; CA4; CA12; CA1; CA9; | |
MAPT; | |
SMN1;SMN2; |
Cytochrome P450 Enzymes: | CYP3A4; |
---|
Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
Protein Kinase | ATR | Serine-protein kinase ATR | Q13535 | CHEMBL5024 |
Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 8.029E-14 | 3.496E-10 | CA1, CA12, CA2, CA4, CA7, CA9 |
BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 1.463E-06 | 3.539E-03 | CA2, CA7 |
MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 1.108E-19 | 2.412E-15 | CA1, CA12, CA14, CA2, CA4, CA7, CA9 |
BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 6.537E-16 | 7.117E-12 | CA1, CA12, CA14, CA2, CA4, CA7, CA9 |
Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|
hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 2.623E-19 | 5.508E-18 | CA12; CA1; CA2; CA4; CA7; CA9; CA14 |
hsa04964 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.142E-04 | 1.199E-03 | CA2; CA4 |
hsa04976 | Bile secretion_Homo sapiens_hsa04976 | 1.100E-03 | 7.700E-03 | CA2; CYP3A4 |
hsa03013 | RNA transport_Homo sapiens_hsa03013 | 6.252E-03 | 3.282E-02 | SMN2; SMN1 |
ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
---|---|---|---|
NA: NA | Edema | NA | CA2 |
I00-I99: Diseases of the circulatory system | Edema associated with congestive heart failure | I50, R60.9 | CA2 |
G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | MAPT |
C00-D49: Neoplasms | Renal cancer | C64 | CA9 |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | CYP3A4 |
K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA2; CA1 |
H00-H59: Diseases of the eye and adnexa | Ocular hypertension | H40.0 | CA4; CA4 |
H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA2; CA4 |
C00-D49: Neoplasms | Solid tumours | C00-D48 | CA9; ATR |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CA2 |
H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | CA1 |
G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | MAPT |
G00-G99: Diseases of the nervous system G00-G99 | Spinal muscular atrophy | G00-G99 | SMN1;SMN2 |
C00-D49: Neoplasms | Lymphoma | C81-C86 | CA9 |
C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9 |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | MAPT |
H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | CA1; CA1 |
C00-D49: Neoplasms | Chronic lymphocytic leukaemia | C91 | ATR |
G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | MAPT |
C00-D49: Neoplasms | Breast cancer | C50 | CA9 |
I00-I99: Diseases of the circulatory system | High blood pressure | I10-I16 | CA2 |
C00-D49: Neoplasms | Cancer | C00-C96 | CA1; CA9; ATR |