Cytochrome P450 Enzymes: |
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Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
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GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 4.930E-11 | 1.073E-06 | CA12, CA2, CA7, CA9 |
BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 2.116E-09 | 2.304E-05 | CA12, CA2, CA7, CA9 |
BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 4.868E-09 | 3.533E-05 | CA12, CA2, CA7, CA9 |
BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 7.235E-07 | 2.626E-03 | CA2, CA7 |
Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|
hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 7.476E-11 | 2.018E-09 | CA12; CA2; CA7; CA9 |
hsa05134 | Legionellosis_Homo sapiens_hsa05134 | 3.295E-04 | 4.133E-03 | CASP7; CASP1 |
hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 4.602E-04 | 4.133E-03 | CYP1A2; ALDH1A1 |
hsa05133 | Pertussis_Homo sapiens_hsa05133 | 6.124E-04 | 4.133E-03 | CASP7; CASP1 |
hsa05010 | Alzheimer's disease_Homo sapiens_hsa05010 | 3.020E-03 | 1.359E-02 | CASP7; HSD17B10 |
hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 2.049E-02 | 4.914E-02 | CYP1A2; ALDH1A1; HSD17B10 |
hsa00380 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.983E-02 | 4.914E-02 | CYP1A2 |
hsa00280 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.375E-02 | 4.914E-02 | HSD17B10 |
hsa04966 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.342E-02 | 4.323E-02 | CA2 |
hsa04964 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.144E-02 | 4.323E-02 | CA2 |
hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.441E-02 | 4.323E-02 | CYP1A2 |
hsa05014 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 2.521E-02 | 4.914E-02 | CASP1 |
hsa04621 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 2.814E-02 | 4.914E-02 | CASP1 |
hsa04971 | Gastric acid secretion_Homo sapiens_hsa04971 | 3.640E-02 | 4.914E-02 | CA2 |
hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 3.398E-02 | 4.914E-02 | CYP1A2 |
hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 2.863E-02 | 4.914E-02 | CYP1A2 |
hsa04623 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 3.155E-02 | 4.914E-02 | CASP1 |
hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 3.591E-02 | 4.914E-02 | CYP1A2 |
hsa04976 | Bile secretion_Homo sapiens_hsa04976 | 3.495E-02 | 4.914E-02 | CA2 |
hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 2.498E-03 | 1.349E-02 | CYP1A2 |
ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
---|---|---|---|
C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9 |
C00-D49: Neoplasms | Renal cancer | C64 | CA9 |
C00-D49: Neoplasms | Cancer | C00-C96 | CA9 |
G00-G99: Diseases of the nervous system G00-G99 | Epilepsy | G40 | CASP1 |
C00-D49: Neoplasms | Solid tumours | C00-D48 | CA9 |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CA2 |
C00-D49: Neoplasms | Lymphoma | C81-C86 | CA9 |
I00-I99: Diseases of the circulatory system | Edema associated with congestive heart failure | I50, R60.9 | CA2 |
NA: NA | Edema | NA | CA2 |
H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA2 |
I00-I99: Diseases of the circulatory system | High blood pressure | I10-I16 | CA2 |
M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | CASP1 |
K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA2 |
C00-D49: Neoplasms | Breast cancer | C50 | CA9 |
L00-L99: Diseases of the skin and subcutaneous tissue | Fibrosis | L90.5 | CASP1 |