Cytochrome P450 Enzymes: |
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Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
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GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
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BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 3.528E-12 | 7.682E-08 | CYP1A2, CYP2C19, CYP2C9, CYP2D6 |
BP | GO:0008152; metabolic process | GO:0008202; steroid metabolic process | 1.870E-08 | 8.144E-05 | CYP1A2, CYP2C19, CYP2C9, CYP2D6, HSD17B2, NPC1 |
MF | GO:0005488; binding | GO:0019825; oxygen binding | 3.442E-08 | 1.071E-04 | CYP1A2, CYP2C19, CYP2C9, CYP2D6 |
BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 4.532E-08 | 1.233E-04 | CYP1A2, CYP2C19, CYP2C9 |
BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 8.300E-08 | 1.506E-04 | CYP1A2, CYP2C19, CYP2C9 |
BP | GO:0008152; metabolic process | GO:0070989; oxidative demethylation | 8.300E-08 | 1.506E-04 | CYP1A2, CYP2C9, CYP2D6 |
MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 1.714E-07 | 2.871E-04 | CA12, CA4, CA7 |
BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 4.997E-07 | 7.668E-04 | CYP1A2, CYP2C19, CYP2C9 |
BP | GO:0008152; metabolic process | GO:0006805; xenobiotic metabolic process | 1.494E-06 | 1.414E-03 | CYP1A2, CYP2C19, CYP2C9, CYP2D6 |
MF | GO:0003824; catalytic activity | GO:0008395; steroid hydroxylase activity | 2.235E-06 | 1.946E-03 | CYP2C19, CYP2C9, CYP2D6 |
MF | GO:0005488; binding | GO:0020037; heme binding | 2.373E-06 | 1.987E-03 | CYP1A2, CYP2C19, CYP2C9, CYP2D6 |
BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 2.664E-06 | 2.148E-03 | CA12, CA4, CA7 |
MF | GO:0003824; catalytic activity | GO:0034875; caffeine oxidase activity | 3.374E-06 | 2.449E-03 | CYP1A2, CYP2C9 |
BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 4.923E-06 | 3.353E-03 | CA12, CA4, CA7 |
MF | GO:0005488; binding | GO:0005506; iron ion binding | 5.764E-06 | 3.692E-03 | CYP1A2, CYP2C19, CYP2C9, CYP2D6 |
BP | GO:0008152; metabolic process | GO:0009820; alkaloid metabolic process | 1.179E-05 | 6.699E-03 | CYP1A2, CYP2D6 |
Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
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hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.721E-07 | 4.267E-06 | CYP2C9; CYP2D6; CYP1A2; CYP2C19 |
hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.233E-06 | 1.520E-05 | CYP2C9; CYP1A2; CYP2C19 |
hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 2.306E-07 | 4.267E-06 | CA12; CA4; CA7 |
hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 1.450E-05 | 1.341E-04 | CYP2C9; CYP1A2; ALDH1A1 |
hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 2.057E-05 | 1.522E-04 | CYP2C9; CYP2D6; CYP1A2 |
hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 7.406E-05 | 3.915E-04 | CYP2C9; CYP2D6; CYP2C19 |
hsa05204 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 2.917E-05 | 1.799E-04 | CYP2C9; CYP1A2; CYP2C19 |
hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 1.720E-04 | 7.954E-04 | CYP2C9; ALDH2; HSD17B2; CYP1A2; ALDH1A1; CYP2C19 |
hsa00380 | Tryptophan metabolism_Homo sapiens_hsa00380 | 4.028E-04 | 1.656E-03 | ALDH2; CYP1A2 |
hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 9.673E-04 | 3.254E-03 | CYP2C9; CYP2C19 |
hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 8.471E-04 | 3.134E-03 | CYP1A2; HSD17B2 |
hsa00340 | Histidine metabolism_Homo sapiens_hsa00340 | 1.786E-02 | 4.719E-02 | ALDH2 |
hsa04964 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.712E-02 | 4.719E-02 | CA4 |
hsa00053 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 2.007E-02 | 4.950E-02 | ALDH2 |
hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 3.745E-03 | 1.155E-02 | CYP1A2 |
ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
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G00-G99: Diseases of the nervous system G00-G99 | Parkinson's disease | G20 | ACHE |
G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | ACHE |
A00-B99: Certain infectious and parasitic diseases | Pediculus humanus capitis | B85.0 | ACHE |
C00-D49: Neoplasms | Cancer | C00-C96 | HIF1A; ACHE |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Alcohol use disorders | F10.2 | ALDH2 |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Substance dependence | F10-F19 | ALDH2 |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Mild cognitive impairment | F06.7 | ACHE |
K00-K95: Diseases of the digestive system | Xerostomia | K11.7, R68.2 | ACHE |
NA: NA | Early satiation associated with functional dyspepsia | NA | ACHE |
G00-G99: Diseases of the nervous system G00-G99 | Epileptic seizures | G40, P90, R56 | ACHE |
A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | RAB9A |
A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE |
C00-D49: Neoplasms | Lymphoma | C81-C86 | HIF1A |
A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | CYP2C9 |
C00-D49: Neoplasms | Solid tumours | C00-D48 | HIF1A |
H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | ACHE |
I00-I99: Diseases of the circulatory system | Pulmonary arterial hypertension | I27.0, I27.2 | HIF1A |
G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis | G70.0 | ACHE |
G00-G99: Diseases of the nervous system G00-G99 | Migraine | G43 | CYP2D6 |
G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | ACHE; ACHE; ACHE |
G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | ACHE |
I00-I99: Diseases of the circulatory system | Cerebrovascular ischaemia | I61-I63 | ALDH2 |
N00-N99: Diseases of the genitourinary system | Urinary dysfunction | N39.3-N39.4 | ACHE |
NA: NA | Upper abdominal bloating | NA | ACHE |
H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | ACHE |
G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis diagnosis | G70.0 | ACHE |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CYP2D6 |
S00-T88: Injury, poisoning and certain other consequences of external causes | Poisoning due to pesticides and chemicals | T36-T50 | ACHE |
S00-T88: Injury, poisoning and certain other consequences of external causes | Poison intoxication | T36-T50 | ACHE |
H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA4; ACHE |
H00-H59: Diseases of the eye and adnexa | Ocular hypertension | H40.0 | CA4; CA4 |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | ACHE |
A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | CYP2D6 |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | ACHE |