CMAUP Plant Collective Molecular Activities

Plant Name: Solanum nigrum

Taxonomic Information:

Plant ID: NPO2211
Plant Latin Name: Solanum nigrum
Taxonomy Genus: Solanum
Taxonomy Family: Solanaceae

Plant External Links:

NCBI TaxonomyDB: 4112
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Israel; Indonesia; Italy; Mexico; Guinea; Tanzania; Finland; India; Malaysia; Rwanda; Jordan; Vietnam; Thailand; Kenya; South Korea; China; Philippines; Bulgaria

Traditional Medicine System:

Sowa-Rigpa; Indian Folk; Unani; Siddha; Ayurveda; TCM; Homeopathy

Medicinal Functions:

Antiperiodic; Antiphlogistic; Antipsoriatic; Diaphoretic; Diuretic; Emollient; Febrifuge; Narcotic; Purgative; Sedative

Geographical Distribution:

Israel; Indonesia; Italy; Mexico; Guinea; Philippines; Finland; India; Malaysia; Rwanda; China; Vietnam; Kenya; Jordan; South Korea; Tanzania; Thailand; Bulgaria

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Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3; ADORA2A; ADORA1; CHRM2; CHRM3; CHRM4; CHRM5; CHRM1;
Peptide receptor (family A GPCR)	TSHR; NPSR1;
Enzyme_unclassified	ALPL; RECQL; TDP1; ADK; TERT; GLO1; PGD; ALOX12; HSD17B1; HSD17B2; HSD17B10; NOX4; POLB; APEX1;
Hydrolase	ACHE;
Miscellaneous ion channel	BCL2;
Isomerase	TOP2A;
Protein Kinase	MET; AXL; FLT3; CDK1; PIM1; KDR; IGF1R; AURKB; CSNK2A1;
Lyase	CA2; CA12; CA9; CA14; CA7; CA4;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Oxidoreductase	TYR;
Lysine demethylase	KDM4E;
Metallo protease	MMP12; MMP9; MMP1; MMP2;
Transcription Factor	AHR; HIF1A; NFKB1;
Transferase	FUT7;
DNA methyltransferase	DNMT1;
ATP-binding cassette	ABCB1;
Methyl-lysine/arginine binding protein	L3MBTL1;
Unclassified	LMNA; THPO; SIGMAR1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCB1	P-glycoprotein 1	P08183	CHEMBL4302
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
DNA methyltransferase	DNMT1	DNA (cytosine-5)-methyltransferase 1	P26358	CHEMBL1993
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	ADK	Adenosine kinase	P55263	CHEMBL3589
Enzyme_unclassified	TERT	Telomerase reverse transcriptase	O14746	CHEMBL2916
Enzyme_unclassified	GLO1	Glyoxalase I	Q04760	CHEMBL2424
Enzyme_unclassified	PGD	6-phosphogluconate dehydrogenase	P52209	CHEMBL3404
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Enzyme_unclassified	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Isomerase	TOP2A	DNA topoisomerase II alpha	P11388	CHEMBL1806
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Metallo protease	MMP1	Matrix metalloproteinase-1	P03956	CHEMBL332
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Methyl-lysine/arginine binding protein	L3MBTL1	Lethal(3)malignant brain tumor-like protein 1	Q9Y468	CHEMBL1287622
Miscellaneous ion channel	BCL2	Apoptosis regulator Bcl-2	P10415	CHEMBL4860
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Oxidoreductase	TYR	Tyrosinase	P14679	CHEMBL1973
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Protein Kinase	CSNK2A1	Casein kinase II alpha	P68400	CHEMBL3629
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256
Small molecule receptor (family A GPCR)	ADORA2A	Adenosine A2a receptor	P29274	CHEMBL251
Small molecule receptor (family A GPCR)	ADORA1	Adenosine A1 receptor	P30542	CHEMBL226
Small molecule receptor (family A GPCR)	CHRM2	Muscarinic acetylcholine receptor M2	P08172	CHEMBL211
Small molecule receptor (family A GPCR)	CHRM3	Muscarinic acetylcholine receptor M3	P20309	CHEMBL245
Small molecule receptor (family A GPCR)	CHRM4	Muscarinic acetylcholine receptor M4	P08173	CHEMBL1821
Small molecule receptor (family A GPCR)	CHRM5	Muscarinic acetylcholine receptor M5	P08912	CHEMBL2035
Small molecule receptor (family A GPCR)	CHRM1	Muscarinic acetylcholine receptor M1	P11229	CHEMBL216
Transcription Factor	AHR	Aryl hydrocarbon receptor	P35869	CHEMBL3201
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Transferase	FUT7	Alpha-(1,3)-fucosyltransferase 7	Q11130	CHEMBL3596077
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256
Unclassified	SIGMAR1	Sigma opioid receptor	Q99720	CHEMBL287

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0050896; response to stimulus	GO:0007197; adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway	3.138E-13	2.278E-09	CHRM1, CHRM2, CHRM3, CHRM4, CHRM5
MF	GO:0060089; molecular transducer activity	GO:0016907; G-protein coupled acetylcholine receptor activity	3.138E-13	2.278E-09	CHRM1, CHRM2, CHRM3, CHRM4, CHRM5
BP	GO:0050896; response to stimulus	GO:0007207; phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway	1.878E-12	1.023E-08	CHRM1, CHRM2, CHRM3, CHRM4, CHRM5
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	4.611E-12	2.008E-08	CA12, CA14, CA2, CA4, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	6.043E-09	5.061E-06	CA12, CA14, CA2, CA4, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.095E-07	5.297E-05	CA12, CA2, CA4, CA7, CA9
MF	GO:0005488; binding	GO:0019825; oxygen binding	3.469E-07	1.349E-04	CYP19A1, CYP1A1, CYP1A2, CYP1B1, NOX4
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	8.683E-07	2.822E-04	CYP19A1, CYP1A1, CYP1A2, CYP1B1
MF	GO:0060089; molecular transducer activity	GO:0001609; G-protein coupled adenosine receptor activity	1.147E-06	3.460E-04	ADORA1, ADORA2A, ADORA3
MF	Unclassified;	GO:0004872; receptor activity	1.420E-06	4.068E-04	ADORA1, ADORA2A, ADORA3, AHR, AXL, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, ESR2, FLT3, IGF1R, KDR, MET, NPSR1, SIGMAR1, TSHR
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.760E-06	4.792E-04	CA12, CA2, CA4, CA7, CA9, DNMT1, ESR2, GLO1, L3MBTL1, MMP1, MMP12, MMP2, MMP9
BP	GO:0051179; localization	GO:0051050; positive regulation of transport	2.100E-06	5.444E-04	ABCB1, ACHE, ADORA1, ADORA2A, AXL, BCL2, CA2, CDK1, CHRM1, CYP19A1, HIF1A, MMP12, NPSR1, TERT
BP	GO:0009987; cellular process	GO:0001973; adenosine receptor signaling pathway	2.739E-06	6.627E-04	ADORA1, ADORA2A, ADORA3
BP	GO:0050896; response to stimulus	GO:0033993; response to lipid	3.146E-06	7.445E-04	ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, FLT3, HSD17B2, NFKB1, TYR
MF	GO:0005488; binding	GO:0051879; Hsp90 protein binding	3.450E-06	7.991E-04	AHR, CSNK2A1, HIF1A, KDR
BP	GO:0051179; localization	GO:2001225; regulation of chloride transport	3.904E-06	8.674E-04	ABCB1, CA2, CA7
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	3.904E-06	8.674E-04	CYP1A1, CYP1A2, CYP1B1
BP	Unclassified;	GO:2000021; regulation of ion homeostasis	5.038E-06	1.097E-03	ADORA1, ADORA2A, BCL2, CA2, CA7, KDR, NPSR1
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	5.241E-06	1.122E-03	ALOX12, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B10, HSD17B2, KDM4E, NOX4, PGD, TYR
CC	GO:0044425; membrane part	GO:0005887; integral component of plasma membrane	8.120E-06	1.593E-03	ADORA1, ADORA2A, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FLT3, IGF1R, KDR, MET, NPSR1, SIGMAR1, TSHR
BP	Unclassified;	GO:0044259; multicellular organismal macromolecule metabolic process	8.924E-06	1.720E-03	HIF1A, MMP1, MMP12, MMP2, MMP9
BP	GO:0008152; metabolic process	GO:0006703; estrogen biosynthetic process	9.239E-06	1.734E-03	CYP19A1, HSD17B1, HSD17B2
BP	GO:0023052; signaling	GO:0032230; positive regulation of synaptic transmission, GABAergic	9.239E-06	1.734E-03	ADORA2A, CA2, CA7
BP	GO:0009987; cellular process	GO:0006286; base-excision repair, base-free sugar-phosphate removal	1.047E-05	1.932E-03	APEX1, POLB
BP	Unclassified;	GO:0044236; multicellular organism metabolic process	2.470E-05	3.984E-03	HIF1A, MMP1, MMP12, MMP2, MMP9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	3.134E-05	4.599E-03	CA2, CA7
MF	GO:0005488; binding	GO:0046982; protein heterodimerization activity	3.166E-05	4.599E-03	ADORA1, ADORA2A, AHR, AXL, BCL2, HIF1A, NFKB1, TOP2A, TYR
CC	GO:0044464; cell part	GO:0099056; integral component of presynaptic membrane	3.134E-05	4.599E-03	ADORA1, ADORA2A
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	3.168E-05	4.599E-03	ADORA1, CA2, CA4, CA9, CHRM3, TSHR
BP	GO:0050896; response to stimulus	GO:0046686; response to cadmium ion	3.323E-05	4.792E-03	CDK1, CYP1A2, MMP9, TERT
BP	GO:0065007; biological regulation	GO:0048872; homeostasis of number of cells	3.813E-05	5.357E-03	AXL, BCL2, FLT3, HIF1A, POLB
BP	GO:0008152; metabolic process	GO:0070988; demethylation	4.087E-05	5.633E-03	APEX1, CYP1A1, CYP1A2, KDM4E
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	4.217E-05	5.775E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	4.247E-05	5.781E-03	AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1
BP	GO:0009987; cellular process	GO:0070301; cellular response to hydrogen peroxide	4.664E-05	6.308E-03	APEX1, AXL, CDK1, CYP1B1
BP	GO:0008283; cell proliferation	GO:1904707; positive regulation of vascular smooth muscle cell proliferation	4.872E-05	6.548E-03	MMP2, MMP9, TERT
BP	GO:0050896; response to stimulus	GO:0009725; response to hormone	5.047E-05	6.742E-03	ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, FLT3, NFKB1, TSHR
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	5.589E-05	7.421E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0030574; collagen catabolic process	5.992E-05	7.813E-03	MMP1, MMP12, MMP2, MMP9
BP	GO:0009987; cellular process	GO:0007569; cell aging	5.992E-05	7.813E-03	BCL2, CDK1, NOX4, TERT
MF	GO:0005488; binding	GO:0020037; heme binding	6.104E-05	7.912E-03	CYP19A1, CYP1A1, CYP1A2, CYP1B1, NOX4
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	6.255E-05	8.060E-03	CYP1A1, CYP1A2
BP	GO:0050896; response to stimulus	GO:0046688; response to copper ion	7.225E-05	8.789E-03	CDK1, CYP1A1, CYP1A2
MF	GO:0005488; binding	GO:0044877; macromolecular complex binding	7.278E-05	8.804E-03	ACHE, ADORA1, APEX1, CSNK2A1, FLT3, IGF1R, KDR, L3MBTL1, MMP12, MMP9, PIM1, TSHR

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	9.216E-12	1.364E-09	CA12, CA2, CA4, CA7, CA9, CA14
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.092E-08	8.077E-07	HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R
09150 Organismal Systems	09156 Nervous system	hsa04725	Cholinergic synapse	5.738E-08	2.123E-06	CHRM2, CHRM3, ACHE, CHRM1, CHRM4, CHRM5, BCL2
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.726E-08	1.345E-06	HSD17B1, CYP1A2, HSD17B2, CYP1A1, CYP1B1, CYP19A1
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2.027E-07	6.001E-06	CHRM2, CHRM3, CHRM1, ADORA2A, CHRM4, ADORA3, CHRM5, ADORA1, TSHR
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	4.013E-06	8.679E-05	FLT3, MMP1, MMP2, BCL2, HIF1A, MET, MMP9, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	4.105E-06	8.679E-05	DNMT1, ABCB1, PIM1, BCL2, CYP1B1, MMP9, MET, NFKB1
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	4.264E-05	7.011E-04	MMP2, KDR, HIF1A, MMP9, MET, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	3.815E-05	7.011E-04	CHRM2, CHRM1, ADORA2A, ADORA1, NFKB1, TSHR
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	9.604E-05	1.421E-03	CHRM2, CHRM1, KDR, BCL2, MET, NFKB1, IGF1R
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.064E-04	1.432E-03	DNMT1, ADK, ALOX12, PGD, TYR, CYP19A1, HSD17B10, FUT7, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL
09130 Environmental Information Processing	09132 Signal transduction	hsa04020	Calcium signaling pathway	2.573E-04	2.697E-03	CHRM2, CHRM3, CHRM1, ADORA2A, CHRM5
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	2.903E-04	2.697E-03	MMP2, PIM1, BCL2, NFKB1
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	2.573E-04	2.697E-03	FLT3, MMP9, MET, NFKB1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	3.129E-04	2.724E-03	BCL2, HIF1A, NFKB1, IGF1R
09140 Cellular Processes	09142 Cell motility	hsa04810	Regulation of actin cytoskeleton	5.683E-04	4.427E-03	CHRM2, CHRM3, CHRM1, CHRM4, CHRM5
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	2.708E-04	2.697E-03	CYP1A2, CYP1A1, CYP1B1
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	5.587E-04	4.427E-03	ADORA3, ADORA1, BCL2, NFKB1
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	2.915E-04	2.697E-03	MMP1, MMP2, MMP9
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	7.720E-04	5.713E-03	FLT3, PIM1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	1.236E-03	8.711E-03	FLT3, MET, HIF1A

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
J00-J99: Diseases of the respiratory system	Bronchodilator	J45	CHRM4;
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; MET; CDK1; IGF1R; KDR; CSNK2A1; NFKB1; FLT3; ACHE; HIF1A; ADORA3; DNMT1; MMP9; MMP2; ABCB1; CA9; BCL2;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Genetic disease	Q00-Q99	ALPL;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	MMP1;
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	ADORA2A;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnosing bronchial hyperreactivity	W88	CHRM3;
I00-I99: Diseases of the circulatory system	Cardiac arrhythmias	I47-I49	ADORA1;
I00-I99: Diseases of the circulatory system	Cardiac disease	I00-I99	ADORA1;
I00-I99: Diseases of the circulatory system	Aortic aneurysm	I71	MMP12;
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
NA: NA	Edema	NA	CA2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Emesis	R11	CHRM4;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ADORA1;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
G00-G99: Diseases of the nervous system G00-G99	Amyotrophic lateral sclerosis	G12.2	BCL2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Anesthesia	R20.0	CHRM1;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Fatigue	R53	ADORA1;
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	CHRM5;
NA: NA	Dystonia	NA	CHRM1;
NA: NA	Dysuria	NA	CHRM4;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
NA: NA	Moderate and severe psychomotor agitation	NA	CHRM4;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE; CHRM1; CHRM2; CHRM3; CHRM4;
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ADORA1;
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADORA2A; CHRM5;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Amnesia	F04	CHRM5;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE; CHRM4;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
NA: NA	Extrapyramidal disorders secondary to neuroleptic drug therapy	NA	CHRM1;
NA: NA	Excessive sweating	NA	CHRM1;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	CHRM1; CHRM2; CHRM3; CHRM5;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Postoperative nausea and vomiting	R11	CHRM3;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	ADK;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE; ADK;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADORA1; ADORA2A; CHRM4;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypertriglyceridemia	E78.1, E78.2, E78.3, I47-I49	ADORA1;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Advanced melanoma	C43	BCL2;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; TERT; FLT3; DNMT1;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Radionuclide imaging	W88	ADORA2A;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
K00-K95: Diseases of the digestive system	Gastric motility disorder	K22.4	CHRM4;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3; MMP9;
C00-D49: Neoplasms	Colon cancer	C50	FLT3; ALPL;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MMP12;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR; ADORA3;
NA: NA	Hepatitis C virus infection	NA	ADORA3;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB;
C00-D49: Neoplasms	Adrenocortical carcinoma	C74.0	ABCB1;
NA: NA	Addiction	NA	CHRM2;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL; DNMT1; ABCB1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ADORA1;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
I00-I99: Diseases of the circulatory system	Coronary disorder diagnosis	I20-I25	ADORA2A;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Convulsions	R56.0	ADK;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
NA: NA	HIV infections	NA	AHR;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
A00-B99: Certain infectious and parasitic diseases	Sepsis	A40, A41	ADORA1;
L00-L99: Diseases of the skin and subcutaneous tissue	Seborrhea	L21	CHRM3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	CHRM1; CHRM5;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
NA: NA	Schizoaffective disorders	NA	CHRM1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	MMP1; TYR;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	DNMT1;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; TERT; KDR;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A; CA9; BCL2;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TERT; KDR;
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADORA1; CHRM2;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE; ADORA1; ADORA2A; CHRM1; CHRM2; CHRM4;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
NA: NA	Abdominal stomach pain	NA	CHRM1;
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	MMP2;
I00-I99: Diseases of the circulatory system	Acute and chronic heart failure	I50	ADORA1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Spasm	R25.2	CHRM4;
C00-D49: Neoplasms	Solid tumours	C00-D48	TOP2A; MET; AURKB; IGF1R; KDR; FLT3; HIF1A; CHRM4; MMP9; MMP2; ABCB1; CA9;
NA: NA	Spasms	NA	CHRM3;
C00-D49: Neoplasms	Soft tissue sarcoma	C00-D49	DNMT1;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	ADORA3;
A00-B99: Certain infectious and parasitic diseases	Irritable bowel syndrome	A09, K58, K59.1	CHRM1; CHRM4; CHRM5;
NA: NA	Gastritis	NA	CHRM4;
K00-K95: Diseases of the digestive system	Gastrointestinal disease	K00-K93	CHRM4;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	ABCB1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Sjogren's syndrome	M35.0	CHRM3;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR; CHRM2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
NA: NA	GIST	NA	FLT3;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE; ADORA1; ADORA2A; ADORA3; CHRM1; CHRM3; CHRM4;
C00-D49: Neoplasms	Glioma	C71	KDR;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
C00-D49: Neoplasms	Glioblastoma multiforme	C71	DNMT1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
NA: NA	Uveitis	NA	CHRM4;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR; DNMT1;
H00-H59: Diseases of the eye and adnexa	Mydriasis diagnosis	H57.0	CHRM4;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE; CHRM5;
G00-G99: Diseases of the nervous system G00-G99	Central and peripheral nervous diseases	G96.9	CHRM4; CHRM5;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	MMP12; ADORA2A; CHRM1; CHRM3; CHRM4; CHRM5;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	TYR;
NA: NA	Vomiting	NA	CHRM4;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Visceral spasms	R25.2	CHRM1;
H00-H59: Diseases of the eye and adnexa	Produce mydriasis and cycloplegia for diagnostic purposes	H57.04	CHRM4;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	ADORA1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Nausea	R11	CHRM2; CHRM4;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
C00-D49: Neoplasms	Prostate cancer	C61	TERT; FLT3; BCL2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	CHRM1;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
J00-J99: Diseases of the respiratory system	Respiratory disease	J00-J99	CHRM3;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR; MMP2;
C00-D49: Neoplasms	Renal cancer	C64	KDR; CA9;
N00-N99: Diseases of the genitourinary system	Renal failure	N17, N18, N19	ADORA1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Nocturia	R35	CHRM4;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	ADORA1; ADORA2A; CHRM1;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1; CHRM1; CHRM5;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
C00-D49: Neoplasms	Melanoma	C43	TERT; KDR; TYR;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Melasma	L81.1	TYR;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Urinary retention	R33	CHRM4;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
NA: NA	Urgency	NA	CHRM4;
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MMP9;
NA: NA	Upper abdominal bloating	NA	ACHE;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR; MMP2;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3; BCL2;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3; BCL2;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
E00-E89: Endocrine, nutritional and metabolic diseases	Atrial fibrillation	E78, I48	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ADORA1;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A;
C00-D49: Neoplasms	Ocular cancer	C69	APEX1;
J00-J99: Diseases of the respiratory system	Obstructive lung diseases	J40-J44, J47	CHRM3;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; ACHE; CA2;
H00-H59: Diseases of the eye and adnexa	Ocular inflammation	H16.229	TERT;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R; TERT; AHR; BCL2;
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	ADORA2A;
J00-J99: Diseases of the respiratory system	Asthma	J45	MMP12; ADORA1; ADORA2A; CHRM2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	MMP1;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	MMP12;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3;
S00-T88: Injury, poisoning and certain other consequences of external causes	Organophosphate poisoning	T60.0	CHRM4;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	MMP2;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
H00-H59: Diseases of the eye and adnexa	Acquired nystagmus	H55	CHRM4;
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	BCL2;
N00-N99: Diseases of the genitourinary system	Overactive bladder	N32.81	CHRM3;
C00-D49: Neoplasms	Ovarian cancer	C56	TERT; KDR; MMP2; ABCB1;
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	CHRM1; CHRM3; CHRM4;
NA: NA	Functional bowel syndrome	NA	CHRM1;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ADORA3;
C00-D49: Neoplasms	CLL	NA	FLT3;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE; ADORA1; CHRM1; CHRM5;
K00-K95: Diseases of the digestive system	Colitis	K50-K52	CHRM5;
I00-I99: Diseases of the circulatory system	Orthostatic hypotension	I95.1	ADORA1;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CDK1; IGF1R; ACHE; ADORA2A; ADK; CHRM3;
C00-D49: Neoplasms	Pancreatic cancer	C25	TERT; KDR; FLT3; MMP2;
K00-K95: Diseases of the digestive system	Peptic ulcer	K25-K27	CHRM1; CHRM2; CHRM4;
NA: NA	Peptic ulcer disease	NA	CHRM4;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	CHRM4;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR; TSHR;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
C00-D49: Neoplasms	Tumors	C00-D48	TERT;
K00-K95: Diseases of the digestive system	Pancreatitis	K85, K86.0K86.1	CHRM4;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cough	R05	CHRM4;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	MMP9;
NA: NA	Suprapubic pain	NA	CHRM4;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Stabilize muscle contractions	M00-M99	CHRM2;
K00-K95: Diseases of the digestive system	Stomach ulcer	K25-K27	CHRM1; CHRM5;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; TERT; KDR; FLT3; CYP19A1; CA9; BCL2;
C00-D49: Neoplasms	Brain cancer	C71, D33	TERT;
G00-G99: Diseases of the nervous system G00-G99	Brain diseases	G00-G99	CHRM5;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases