BIDD Pharmainformatics Databases
Therapeutically Relevant Multiple Pathways Database
National University of Singapore, Science Faculty, Computational Sci Dept
 
 
   

Reference of Pathway
(listed in alphabetical order)
  

1. Ahima, R.S. & Osei, S.Y. Molecular regulation of eating behavior: new insights and prospects for therapeutic strategies. Trends Mol Med 7, 205-213 (2001).
2. Alcami, A. Viral mimicry of cytokines, chemokines and their receptors. Nat Rev Immunol 3, 36-50 (2003).
3. Arner, P. The adipocyte in insulin resistance: key molecules and the impact of the thiazolidinediones. Trends Endocrinol Metab 14, 137-145 (2003).
4. Bader, T., Zoumakis, E., Friedberg, M., Chrousos, G.P. & Hochberg, Z. Human adipose tissue under in vitro inhibition of 11beta-hydroxysteroid dehydrogenase type 1: differentiation and metabolism changes. Horm Metab Res 34, 752-757 (2002).
5. Barsh, G.S., Farooqi, I.S. & O'Rahilly, S. Genetics of body-weight regulation. Nature 404, 644-651 (2000).
6. Barton, M., Carmona, R., Ortmann, J., Krieger, J.E. & Traupe, T. Obesity-associated activation of angiotensin and endothelin in the cardiovascular system. Int J Biochem Cell Biol 35, 826-837 (2003).
7. Baselga, J. Why the epidermal growth factor receptor? The rationale for cancer therapy. Oncologist 7 Suppl 4, 2-8 (2002).
8. Bereswill, S. & Kist, M. Molecular microbiology and pathogenesis of Helicobacter and Campylobacter updated: a meeting report of the 11th conference on Campylobacter, Helicobacter and related organisms. Mol Microbiol 45, 255-262 (2002).
9. Bickerdike, M.J. 5-HT2C receptor agonists as potential drugs for the treatment of obesity. Curr Top Med Chem 3, 885-897 (2003).
10. Blanck, H.M., Khan, L.K. & Serdula, M.K. Use of nonprescription weight loss products: results from a multistate survey. Jama 286, 930-935 (2001).
11. Boquet, P., Munro, P., Fiorentini, C. & Just, I. Toxins from anaerobic bacteria: specificity and molecular mechanisms of action. Curr Opin Microbiol 1, 66-74 (1998).
12. Bradley, R.L., Cleveland, K.A. & Cheatham, B. The adipocyte as a secretory organ: mechanisms of vesicle transport and secretory pathways. Recent Prog Horm Res 56, 329-358 (2001).
13. Bray, G.A. Drug treatment of obesity. Baillieres Best Pract Res Clin Endocrinol Metab 13, 131-148 (1999).
14. Bray, G.A. A concise review on the therapeutics of obesity. Nutrition 16, 953-960 (2000).
15. Bray, G.A. Afferent signals regulating food intake. Proc Nutr Soc 59, 373-384 (2000).
16. Bray, G.A. The underlying basis for obesity: relationship to cancer. J Nutr 132, 3451S-3455S (2002).
17. Bray, G.A. & Tartaglia, L.A. Medicinal strategies in the treatment of obesity. Nature 404, 672-677 (2000).
18. Bullock, A.N. & Fersht, A.R. Rescuing the function of mutant p53. Nat Rev Cancer 1, 68-76 (2001).
19. Cantrell, D. T cell antigen receptor signal transduction pathways. Annu Rev Immunol 14, 259-274 (1996).
20. Chensue, S.W. Molecular machinations: chemokine signals in host-pathogen interactions. Clin Microbiol Rev 14, 821-835, table of contents (2001).
21. Chiang, J.Y. Bile acid regulation of gene expression: roles of nuclear hormone receptors. Endocr Rev 23, 443-463 (2002).
22. Clapham, J.C., Arch, J.R. & Tadayyon, M. Anti-obesity drugs: a critical review of current therapies and future opportunities. Pharmacol Ther 89, 81-121 (2001).
23. Dong, C., Davis, R.J. & Flavell, R.A. MAP kinases in the immune response. Annu Rev Immunol 20, 55-72 (2002).
24. Feldman, B.J. & Feldman, D. The development of androgen-independent prostate cancer. Nat Rev Cancer 1, 34-45 (2001).
25. Fodde, R., Smits, R. & Clevers, H. APC, signal transduction and genetic instability in colorectal cancer. Nat Rev Cancer 1, 55-67 (2001).
26. Frayn, K.N. Non-esterified fatty acid metabolism and postprandial lipaemia. Atherosclerosis 141 Suppl 1, S41-46 (1998).
27. Frayn, K.N. et al. Regulation of fatty acid movement in human adipose tissue in the postabsorptive-to-postprandial transition. Am J Physiol 266, E308-317 (1994).
28. Friedman, J.M. Obesity in the new millennium. Nature 404, 632-634 (2000).
29. Friedman, J.M. & Halaas, J.L. Leptin and the regulation of body weight in mammals. Nature 395, 763-770 (1998).
30. Froguel, P. & Boutin, P. Genetics of pathways regulating body weight in the development of obesity in humans. Exp Biol Med (Maywood) 226, 991-996 (2001).
31. Fruhbeck, G., Gomez-Ambrosi, J., Muruzabal, F.J. & Burrell, M.A. The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation. Am J Physiol Endocrinol Metab 280, E827-847 (2001).
32. Galloway, T.S., Ray, K. & Malhotra, R. Regulation of B lymphocytes in health and disease. Meeting review. Mol Immunol 39, 649-653 (2003).
33. Giles, R.H., van Es, J.H. & Clevers, H. Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta 1653, 1-24 (2003).
34. Goudreau, P.N. & Stock, A.M. Signal transduction in bacteria: molecular mechanisms of stimulus-response coupling. Curr Opin Microbiol 1, 160-169 (1998).
35. Gronke, S. et al. Control of fat storage by a Drosophila PAT domain protein. Curr Biol 13, 603-606 (2003).
36. Habeck, M. A succulent cure to end obesity. Drug Discov Today 7, 280-281 (2002).
37. Halford, J.C. Pharmacology of appetite suppression: implication for the treatment of obesity. Curr Drug Targets 2, 353-370 (2001).
38. Halford, J.C. & Blundell, J.E. Pharmacology of appetite suppression. Prog Drug Res 54, 25-58 (2000).
39. Harper, J.A., Dickinson, K. & Brand, M.D. Mitochondrial uncoupling as a target for drug development for the treatment of obesity. Obes Rev 2, 255-265 (2001).
40. Harris, A.L. Hypoxia--a key regulatory factor in tumour growth. Nat Rev Cancer 2, 38-47 (2002).
41. Hersey, P. & Zhang, X.D. How melanoma cells evade trail-induced apoptosis. Nat Rev Cancer 1, 142-150 (2001).
42. Heumann, D., Glauser, M.P. & Calandra, T. Molecular basis of host-pathogen interaction in septic shock. Curr Opin Microbiol 1, 49-55 (1998).
43. Higuchi, H. & Gores, G.J. Bile acid regulation of hepatic physiology: IV. Bile acids and death receptors. Am J Physiol Gastrointest Liver Physiol 284, G734-738 (2003).
44. Hofbauer, K.G. Molecular pathways to obesity. Int J Obes Relat Metab Disord 26 Suppl 2, S18-27 (2002).
45. Hood, J.D. & Cheresh, D.A. Role of integrins in cell invasion and migration. Nat Rev Cancer 2, 91-100 (2002).
46. Horvath, T.L. et al. Uncoupling proteins-2 and 3 influence obesity and inflammation in transgenic mice. Int J Obes Relat Metab Disord 27, 433-442 (2003).
47. Houseknecht, K.L. & Portocarrero, C.P. Leptin and its receptors: regulators of whole-body energy homeostasis. Domest Anim Endocrinol 15, 457-475 (1998).
48. Jallepalli, P.V. & Lengauer, C. Chromosome segregation and cancer: cutting through the mystery. Nat Rev Cancer 1, 109-117 (2001).
49. Janssens, S. & Beyaert, R. Role of Toll-like receptors in pathogen recognition. Clin Microbiol Rev 16, 637-646 (2003).
50. Kato, S. et al. Molecular mechanism of a cross-talk between oestrogen and growth factor signalling pathways. Genes Cells 5, 593-601 (2000).
51. Katze, M.G., He, Y. & Gale, M., Jr. Viruses and interferon: a fight for supremacy. Nat Rev Immunol 2, 675-687 (2002).
52. Kopelman, P.G. Obesity as a medical problem. Nature 404, 635-643 (2000).
53. Kozak, W. et al. Molecular mechanisms of fever and endogenous antipyresis. Ann N Y Acad Sci 917, 121-134 (2000).
54. Kraus, S., Naor, Z. & Seger, R. Intracellular signaling pathways mediated by the gonadotropin-releasing hormone (GnRH) receptor. Arch Med Res 32, 499-509 (2001).
55. Kuehl, W.M. & Bergsagel, P.L. Multiple myeloma: evolving genetic events and host interactions. Nat Rev Cancer 2, 175-187 (2002).
56. Kwiterovich, P.O., Jr. The metabolic pathways of high-density lipoprotein, low-density lipoprotein, and triglycerides: a current review. Am J Cardiol 86, 5L-10L (2000).
57. Langhans, W. & Hrupka, B. Interleukins and tumor necrosis factor as inhibitors of food intake. Neuropeptides 33, 415-424 (1999).
58. Levy, D.E. & Garcia-Sastre, A. The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion. Cytokine Growth Factor Rev 12, 143-156 (2001).
59. Li, M.D., Kane, J.K. & Konu, O. Nicotine, body weight and potential implications in the treatment of obesity. Curr Top Med Chem 3, 899-919 (2003).
60. Li, X. & Stark, G.R. NFkappaB-dependent signaling pathways. Exp Hematol 30, 285-296 (2002).
61. Loftus, T.M. et al. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 288, 2379-2381 (2000).
62. Lowell, B.B. & Spiegelman, B.M. Towards a molecular understanding of adaptive thermogenesis. Nature 404, 652-660 (2000).
63. Mahalingam, S., Meanger, J., Foster, P.S. & Lidbury, B.A. The viral manipulation of the host cellular and immune environments to enhance propagation and survival: a focus on RNA viruses. J Leukoc Biol 72, 429-439 (2002).
64. Mahley, R.W. & Ji, Z.S. Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E. J Lipid Res 40, 1-16 (1999).
65. Mantyh, P.W., Clohisy, D.R., Koltzenburg, M. & Hunt, S.P. Molecular mechanisms of cancer pain. Nat Rev Cancer 2, 201-209 (2002).
66. Maquoi, E., Demeulemeester, D., Voros, G., Collen, D. & Lijnen, H.R. Enhanced nutritionally induced adipose tissue development in mice with stromelysin-1 gene inactivation. Thromb Haemost 89, 696-704 (2003).
67. Mareel, M. & Leroy, A. Clinical, cellular, and molecular aspects of cancer invasion. Physiol Rev 83, 337-376 (2003).
68. Mathon, N.F. & Lloyd, A.C. Cell senescence and cancer. Nat Rev Cancer 1, 203-213 (2001).
69. Mora, S. & Pessin, J.E. An adipocentric view of signaling and intracellular trafficking. Diabetes Metab Res Rev 18, 345-356 (2002).
70. Moro, C.O. & Basile, G. Obesity and medicinal plants. Fitoterapia 71 Suppl 1, S73-82 (2000).
71. Mudgett, M.B. & Staskawicz, B.J. Protein signaling via type III secretion pathways in phytopathogenic bacteria. Curr Opin Microbiol 1, 109-114 (1998).
72. Mukherjee, R. PPARs: Versatile Targets for Future Therapy for Obesity, Diabetes and Cardiovascular Diseases. Drug News Perspect 15, 261-267 (2002).
73. Muller, G. Dynamics of plasma membrane microdomains and cross-talk to the insulin signalling cascade. FEBS Lett 531, 81-87 (2002).
74. Mulrow, C.D. et al. Efficacy of newer medications for treating depression in primary care patients. Am J Med 108, 54-64 (2000).
75. Mundy, G.R. Metastasis to bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer 2, 584-593 (2002).
76. Naaz, A. et al. Effect of ovariectomy on adipose tissue of mice in the absence of estrogen receptor alpha (ERalpha): a potential role for estrogen receptor beta (ERbeta). Horm Metab Res 34, 758-763 (2002).
77. Naumann, M. Nuclear factor-kappa B activation and innate immune response in microbial pathogen infection. Biochem Pharmacol 60, 1109-1114 (2000).
78. Netea, M.G., Kullberg, B.J. & Van der Meer, J.W. Circulating cytokines as mediators of fever. Clin Infect Dis 31 Suppl 5, S178-184 (2000).
79. Norkin, L.C. Virus receptors: implications for pathogenesis and the design of antiviral agents. Clin Microbiol Rev 8, 293-315 (1995).
80. North, M.A. Advances in the molecular genetics of obesity. Curr Opin Genet Dev 9, 283-288 (1999).
81. Noverr, M.C., Erb-Downward, J.R. & Huffnagle, G.B. Production of eicosanoids and other oxylipins by pathogenic eukaryotic microbes. Clin Microbiol Rev 16, 517-533 (2003).
82. Oria, E. et al. [Weight-loss drugs: composition of diet pills prescribed in Navarra]. An Med Interna 14, 275-281 (1997).
83. Parker, E., Van Heek, M. & Stamford, A. Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status. Eur J Pharmacol 440, 173-187 (2002).
84. Perusse, L. et al. The human obesity gene map: the 2000 update. Obes Res 9, 135-169 (2001).
85. Pillarisetti, S. & Saxena, U. Lipoprotein lipase as a therapeutic target for dyslipidemia. Front Biosci 8, d238-241 (2003).
86. Ramachandran, C. & Kennedy, B.P. Protein tyrosine phosphatase 1B: a novel target for type 2 diabetes and obesity. Curr Top Med Chem 3, 749-757 (2003).
87. Rambukkana, A. Molecular basis for the peripheral nerve predilection of Mycobacterium leprae. Curr Opin Microbiol 4, 21-27 (2001).
88. Rivest, S. et al. How the blood talks to the brain parenchyma and the paraventricular nucleus of the hypothalamus during systemic inflammatory and infectious stimuli. Proc Soc Exp Biol Med 223, 22-38 (2000).
89. Sahai, E. & Marshall, C.J. RHO-GTPases and cancer. Nat Rev Cancer 2, 133-142 (2002).
90. Sanchez-Mejorada, G. & Rosales, C. Signal transduction by immunoglobulin Fc receptors. J Leukoc Biol 63, 521-533 (1998).
91. Sauer, F.G., Mulvey, M.A., Schilling, J.D., Martinez, J.J. & Hultgren, S.J. Bacterial pili: molecular mechanisms of pathogenesis. Curr Opin Microbiol 3, 65-72 (2000).
92. Schuller, H.M. Mechanisms of smoking-related lung and pancreatic adenocarcinoma development. Nat Rev Cancer 2, 455-463 (2002).
93. Schwartz, M.W. Brain pathways controlling food intake and body weight. Exp Biol Med (Maywood) 226, 978-981 (2001).
94. Schwartz, M.W., Woods, S.C., Porte, D., Jr., Seeley, R.J. & Baskin, D.G. Central nervous system control of food intake. Nature 404, 661-671 (2000).
95. Seet, B.T. & McFadden, G. Viral chemokine-binding proteins. J Leukoc Biol 72, 24-34 (2002).
96. Servant, M.J., Grandvaux, N. & Hiscott, J. Multiple signaling pathways leading to the activation of interferon regulatory factor 3. Biochem Pharmacol 64, 985-992 (2002).
97. Silver, L.L. Novel inhibitors of bacterial cell wall synthesis. Curr Opin Microbiol 6, 431-438 (2003).
98. Stan, S., Delvin, E., Lambert, M., Seidman, E. & Levy, E. Apo A-IV: an update on regulation and physiologic functions. Biochim Biophys Acta 1631, 177-187 (2003).
99. Stefan, N. & Stumvoll, M. Adiponectin--its role in metabolism and beyond. Horm Metab Res 34, 469-474 (2002).
100. Suzuki, H., Ueda, T., Ichikawa, T. & Ito, H. Androgen receptor involvement in the progression of prostate cancer. Endocr Relat Cancer 10, 209-216 (2003).
101. Sweeney, G. Leptin signalling. Cell Signal 14, 655-663 (2002).
102. Szewczyk, J.R. & Laudeman, C. CCK1R agonists: a promising target for the pharmacological treatment of obesity. Curr Top Med Chem 3, 837-854 (2003).
103. Thrasher, A.J. WASp in immune-system organization and function. Nat Rev Immunol 2, 635-646 (2002).
104. Tomlinson, J.W. & Stewart, P.M. The functional consequences of 11beta-hydroxysteroid dehydrogenase expression in adipose tissue. Horm Metab Res 34, 746-751 (2002).
105. Trusolino, L. & Comoglio, P.M. Scatter-factor and semaphorin receptors: cell signalling for invasive growth. Nat Rev Cancer 2, 289-300 (2002).
106. Unger, R.H. & Orci, L. Diseases of liporegulation: new perspective on obesity and related disorders. Faseb J 15, 312-321 (2001).
107. Van Amersfoort, E.S., Van Berkel, T.J. & Kuiper, J. Receptors, mediators, and mechanisms involved in bacterial sepsis and septic shock. Clin Microbiol Rev 16, 379-414 (2003).
108. van Crevel, R., Ottenhoff, T.H. & van der Meer, J.W. Innate immunity to Mycobacterium tuberculosis. Clin Microbiol Rev 15, 294-309 (2002).
109. Vivanco, I. & Sawyers, C.L. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2, 489-501 (2002).
110. Wajant, H., Pfizenmaier, K. & Scheurich, P. Non-apoptotic Fas signaling. Cytokine Growth Factor Rev 14, 53-66 (2003).
111. Wange, R.L. LAT, the linker for activation of T cells: a bridge between T cell-specific and general signaling pathways. Sci STKE 2000, RE1 (2000).
112. Webber, J. & Macdonald, I.A. Signalling in body-weight homeostasis: neuroendocrine efferent signals. Proc Nutr Soc 59, 397-404 (2000).
113. Wieland, H.A. & Hamilton, B.S. Weighing the options in the pharmacotherapy of obesity. Int J Clin Pharmacol Ther 39, 406-414 (2001).
114. Wilding, J.P. Leptin and the control of obesity. Curr Opin Pharmacol 1, 656-661 (2001).
115. Williams, G., Harrold, J.A. & Cutler, D.J. The hypothalamus and the regulation of energy homeostasis: lifting the lid on a black box. Proc Nutr Soc 59, 385-396 (2000).
116. Woods, S.C. & Seeley, R.J. Adiposity signals and the control of energy homeostasis. Nutrition 16, 894-902 (2000).
117. Yee, C. & Greenberg, P. Modulating T-cell immunity to tumours: new strategies for monitoring T-cell responses. Nat Rev Cancer 2, 409-419 (2002).

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Last update: 1/1/2004

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