TCM-ID Prescription

Prescription Description

Prescription ID	TCMFx5125
Pinyin Name	Tong Zhong Ling
Chinese Name	痛肿灵
English Name	Tong Zhong Ling
Function Description	痹病, 跌打损伤
Indications	Arthritis
Disease ICD-11 Category	FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病，未特指的 ];
Human Tissues Associated with Indication	SkeletalMuscle, Blood
Reference	CFDA
Reference Book/link	http://samr.cfda.gov.cn/WS01/CL0001/

Prescription Components

Component ID	Latin Name	Chinese Name	Component Quantity	Barcode
TCMH806	Amygdalus persica	汉桃叶	TCMH806
TCMH514	Murraya euchrestifolia	豆叶九里香	TCMH514	ITSAN4855-14
TCMH2014	Saraca chinensis merr.et chun	四方木皮	TCMH2014
TCMH1840	NA	山乌龟	TCMH1840
TCMH830	NA	黑吹风	TCMH830
TCMH2044	Caesalpinia sappan	苏木	TCMH2044	ITSAJ4578-14
TCMH764	Entada phaseoloides	过岗龙	TCMH764	ITSAJ4199-14
TCMH349	Adhatoda vasica	大驳骨	TCMH349	GENG059-12
TCMH1657	Radix moghaniae philippinensis	千斤拔	TCMH1657
TCMH761	Cinnamomum cassia	桂枝	TCMH761	GQ255631
TCMH2287	Justicia gendarussa	小驳骨	TCMH2287	ITSAM887-14
TCMH383	Adenosma indianum	大头陈	TCMH383	GBVU4174-13
TCMH1565	Millettia speciosa champ	牛大力	TCMH1565
TCMH1165	Murraya paniculata	九里香	TCMH1165	ITSAJ1731-14
TCMH2696	Phyllostachys nigra	竹叶	TCMH2696	BBOBC006-15
TCMH924	Zanthoxylum bungeanum	花椒	TCMH924	ITSAJ4650-14
TCMH565	Stephania tetrandra	防己	TCMH565	ITSAG893-14
TCMH353	Blumea balsamifera	大风艾	TCMH353	ITSAG1573-14
TCMH700	Drynaria fortunei	骨碎补	TCMH700	GBVM3977-11
TCMH2290	NA	小风艾	TCMH2290
TCMH1533	Saussurea lappa	木香	TCMH1533
TCMH118	Angelica dahurica	白芷	TCMH118	ITSAK3312-14
TCMH1063	Curcuma longa	姜黄	TCMH1063	ITSAP2805-14
TCMH2684	Ardisia crenata	朱砂根	TCMH2684	ITSAP4502-14
TCMH423	Embelia parviflora	当归藤	TCMH423	GBVY2010-14, GBVP2315-14
TCMH450	Caulis fici tikouae	地瓜藤	TCMH450
TCMH2741	Blumea laciniata	走马风	TCMH2741	GENG1191-15
TCMH2693	Fructus gleditsiae abnormalis	猪牙皂	TCMH2693
TCMH2265	Cyperus rotundus	香附	TCMH2265	GENG1049-15
TCMH2012	Lycopus lucidus	水泽兰	TCMH2012	ITSAH2420-14
TCMH2658	NA	猪肚木皮	TCMH2658
TCMH1036	Spatholobus suberectus	鸡血藤	TCMH1036	ITSAK2607-14
TCMH183	Dryobalanops aromatica	冰片	TCMH183	GBVK4926-11
TCMH2585	Cinnamomum camphora	樟脑	TCMH2585	SDH069-14
TCMH189	Mentholum	薄荷脑	TCMH189

Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID	Gene Symbol	Target Name	Target Class	Uniprot ID
TCMT100	TTR	Transthyretin	Unclassified	P02766
TCMT101	PTPN1	Protein-tyrosine phosphatase 1B	Hydrolase	P18031
TCMT102	ACP1	Low molecular weight phosphotyrosine protein phosphatase	Hydrolase	P24666
TCMT103	PTPRF	Receptor-type tyrosine-protein phosphatase F (LAR)	Hydrolase	P10586
TCMT114	CNR2	Cannabinoid CB2 receptor	GPCR	P34972
TCMT115	CNR1	Cannabinoid CB1 receptor	GPCR	P21554
TCMT127	PARP1	Poly [ADP-ribose] polymerase-1	Transferase	P09874
TCMT130	ALOX5	Arachidonate 5-lipoxygenase	Oxidoreductase	P09917
TCMT131	ACHE	Acetylcholinesterase	Hydrolase	P22303
TCMT133	CA1	Carbonic anhydrase I	Lyase	P00915
TCMT134	CA2	Carbonic anhydrase II	Lyase	P00918
TCMT135	CA14	Carbonic anhydrase XIV	Lyase	Q9ULX7
TCMT136	CA12	Carbonic anhydrase XII	Lyase	O43570
TCMT137	CA9	Carbonic anhydrase IX	Lyase	Q16790
TCMT138	CA7	Carbonic anhydrase VII	Lyase	P43166
TCMT142	CA4	Carbonic anhydrase IV	Lyase	P22748
TCMT150	RORC	Nuclear receptor ROR-gamma	Nuclear receptor	P51449
TCMT154	PRKCD	Protein kinase C delta	Kinase	Q05655
TCMT156	CYP19A1	Cytochrome P450 19A1	Oxidoreductase	P11511
TCMT159	TYR	Tyrosinase	Oxidoreductase	P14679
TCMT162	UGT1A1	UDP-glucuronosyltransferase 1-1	Transferase	P22309
TCMT174	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	Oxidoreductase	P28845
TCMT187	AR	Androgen Receptor	Nuclear receptor	P10275
TCMT189	DUSP3	Dual specificity protein phosphatase 3	Hydrolase	P51452
TCMT190	PTPN2	T-cell protein-tyrosine phosphatase	Hydrolase	P17706
TCMT197	PDE4D	Phosphodiesterase 4D	Hydrolase	Q08499
TCMT206	CYP2A6	Cytochrome P450 2A6	Oxidoreductase	P11509
TCMT208	MAOA	Monoamine oxidase A	Oxidoreductase	P21397
TCMT212	SRC	Tyrosine-protein kinase SRC	Kinase	P12931
TCMT215	CYP1A1	Cytochrome P450 1A1	Oxidoreductase	P04798
TCMT217	CYP2C8	Cytochrome P450 2C8	Oxidoreductase	P10632
TCMT219	CYP1A2	Cytochrome P450 1A2	Oxidoreductase	P05177
TCMT223	AKR1B1	Aldose reductase	Oxidoreductase	P15121
TCMT226	PDPK1	3-phosphoinositide dependent protein kinase-1	Kinase	O15530
TCMT23	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Hydrolase	P05186
TCMT236	ESR2	Estrogen receptor beta	Nuclear receptor	Q92731
TCMT239	PIM1	Serine/threonine-protein kinase PIM1	Kinase	P11309
TCMT243	ADRA2C	Alpha-2c adrenergic receptor	GPCR	P18825
TCMT247	ADRA2A	Alpha-2a adrenergic receptor	GPCR	P08913
TCMT257	CYP1B1	Cytochrome P450 1B1	Oxidoreductase	Q16678
TCMT260	FLT3	Tyrosine-protein kinase receptor FLT3	Kinase	P36888
TCMT261	DAPK1	Death-associated protein kinase 1	Kinase	P53355
TCMT27	DRD1	Dopamine D1 receptor	GPCR	P21728
TCMT280	AKR1B10	Aldo-keto reductase family 1 member B10	Oxidoreductase	O60218
TCMT295	MMP1	Matrix metalloproteinase-1	Hydrolase	P03956
TCMT297	FABP4	Fatty acid binding protein adipocyte	Unclassified	P15090
TCMT298	FABP3	Fatty acid binding protein muscle	Hydrolase	P05413
TCMT301	PTGES	Prostaglandin E synthase	Isomerase	O14684
TCMT306	MMP2	Matrix metalloproteinase-2	Hydrolase	P08253
TCMT321	MMP9	Matrix metalloproteinase 9	Hydrolase	P14780
TCMT322	MMP13	Matrix metalloproteinase 13	Hydrolase	P45452
TCMT337	XPO1	Exportin-1	Unclassified	O14980
TCMT34	CYP2D6	Cytochrome P450 2D6	Oxidoreductase	P10635
TCMT344	AOX1	Aldehyde oxidase	Oxidoreductase	Q06278
TCMT354	AURKA	Serine/threonine-protein kinase Aurora-A	Kinase	O14965
TCMT359	FYN	Tyrosine-protein kinase FYN	Kinase	P06241
TCMT369	IGF1R	Insulin-like growth factor I receptor	Kinase	P08069
TCMT370	KDR	Vascular endothelial growth factor receptor 2	Kinase	P35968
TCMT374	AURKB	Serine/threonine-protein kinase Aurora-B	Kinase	Q96GD4
TCMT377	INSR	Insulin receptor	Kinase	P06213
TCMT388	AXL	Tyrosine-protein kinase receptor UFO	Kinase	P30530
TCMT401	MET	Hepatocyte growth factor receptor	Kinase	P08581
TCMT418	EPHB4	Ephrin type-B receptor 4	Kinase	P54760
TCMT422	CAMK2B	CaM kinase II beta	Kinase	Q13554
TCMT423	EGFR	Epidermal growth factor receptor erbB1	Kinase	P00533
TCMT436	NUAK1	NUAK family SNF1-like kinase 1	Kinase	O60285
TCMT445	NEK2	Serine/threonine-protein kinase NEK2	Kinase	P51955
TCMT45	APP	Beta amyloid A4 protein	Unclassified	P05067
TCMT457	FLT4	Vascular endothelial growth factor receptor 3	Kinase	P35916
TCMT46	F3	Coagulation factor III	Unclassified	P13726
TCMT462	NEK6	Serine/threonine-protein kinase NEK6	Kinase	Q9HC98
TCMT47	BCL2	Apoptosis regulator Bcl-2	Ion channel	P10415
TCMT479	AKT1	Serine/threonine-protein kinase AKT	Kinase	P31749
TCMT484	PLK1	Serine/threonine-protein kinase PLK1	Kinase	P53350
TCMT502	TEK	Tyrosine-protein kinase TIE-2	Kinase	Q02763
TCMT536	PDGFRB	Platelet-derived growth factor receptor beta	Kinase	P09619
TCMT563	CDC25B	Dual specificity phosphatase Cdc25B	Hydrolase	P30305
TCMT565	EP300	Histone acetyltransferase p300	Transferase	Q09472
TCMT566	NOS2	Nitric oxide synthase, inducible	Oxidoreductase	P35228
TCMT570	ANPEP	Aminopeptidase N	Unclassified	P15144
TCMT591	ESRRA	Estrogen-related receptor alpha	Nuclear receptor	P11474
TCMT592	XDH	Xanthine dehydrogenase	Oxidoreductase	P47989
TCMT599	UBE2N	Ubiquitin-conjugating enzyme E2 N	Transferase	P61088
TCMT614	EGLN1	Egl nine homolog 1	Oxidoreductase	Q9GZT9
TCMT626	BRAF	Serine/threonine-protein kinase B-raf	Kinase	P15056
TCMT63	PPARA	Peroxisome proliferator-activated receptor alpha	Nuclear receptor	Q07869
TCMT65	HSD17B1	Estradiol 17-beta-dehydrogenase 1	Oxidoreductase	P14061
TCMT66	HSD17B2	Estradiol 17-beta-dehydrogenase 2	Oxidoreductase	P37059
TCMT678	XIAP	Inhibitor of apoptosis protein 3	Transferase	P98170
TCMT679	MPEG1	Macrophage-expressed gene 1 protein	Unclassified	Q2M385
TCMT680	KAT2B	Histone acetyltransferase PCAF	Transferase	Q92831
TCMT683	MIF	Macrophage migration inhibitory factor	Isomerase	P14174
TCMT721	HSPA1A	Heat shock 70 kDa protein 1	Unclassified	P0DMV8
TCMT734	MMP12	Matrix metalloproteinase 12	Hydrolase	P39900
TCMT739	GPR35	G-protein coupled receptor 35	GPCR	Q9HC97
TCMT752	CSNK2A1	Casein kinase II alpha	Kinase	P68400
TCMT753	SMAD3	Mothers against decapentaplegic homolog 3	Unclassified	P84022
TCMT755	PLK4	Serine/threonine-protein kinase PLK4	Kinase	O00444
TCMT756	MAP3K8	Mitogen-activated protein kinase kinase kinase 8	Kinase	P41279
TCMT784	AVPR2	Vasopressin V2 receptor	GPCR	P30518
TCMT785	CXCR1	Interleukin-8 receptor A	GPCR	P25024
TCMT786	CCR4	C-C chemokine receptor type 4	GPCR	P51679
TCMT791	PKN1	Protein kinase N1	Kinase	Q16512
TCMT793	PYGL	Liver glycogen phosphorylase	Transferase	P06737
TCMT808	FABP5	Fatty acid binding protein epidermal	Unclassified	Q01469
TCMT809	FABP2	Fatty acid binding protein intestinal	Unclassified	P12104
TCMT810	TLR2	Toll-like receptor 2	Unclassified	O60603
TCMT82	ESR1	Estrogen receptor alpha	Nuclear receptor	P03372
TCMT822	FUT7	Alpha-(1,3)-fucosyltransferase 7	Transferase	Q11130
TCMT83	CD38	Lymphocyte differentiation antigen CD38	Unclassified	P28907
TCMT87	CYP2C9	Cytochrome P450 2C9	Oxidoreductase	P11712
TCMT899	ALDH2	Aldehyde dehydrogenase	Oxidoreductase	P05091
TCMT910	ESRRB	Estrogen-related receptor beta	Nuclear receptor	O95718
TCMT962	ENPP2	Autotaxin	Hydrolase	Q13822
TCMT974	GPER1	G-protein coupled estrogen receptor 1	GPCR	Q99527
TCMT99	SHBG	Testis-specific androgen-binding protein	Unclassified	P04278

Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID	Target Name
TCMT1175	Human immunodeficiency virus
TCMT1178	Actinomyces viscosus
TCMT1181	Mycobacterium tuberculosis H37Ra
TCMT1186	Plasmodium yoelii yoelii
TCMT1189	Pseudomonas fluorescens
TCMT1190	Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208	Escherichia coli K12
TCMT1209	Staphylococcus haemolyticus
TCMT1210	Streptococcus sobrinus
TCMT1211	Fusobacterium nucleatum
TCMT1212	Verticillium dahliae
TCMT1213	Neisseria gonorrhoeae
TCMT1214	Enterococcus faecium
TCMT1215	Pseudomonas aeruginosa PAO1
TCMT1218	Staphylococcus aureus
TCMT1219	Enterococcus
TCMT1221	Human herpesvirus 4
TCMT1222	Plasmodium falciparum D6
TCMT1223	Staphylococcus epidermidis
TCMT1224	Proteus mirabilis
TCMT1226	Klebsiella pneumoniae
TCMT1229	Enterococcus faecalis
TCMT1231	Human herpesvirus 1 strain KOS
TCMT1232	Pseudomonas aeruginosa
TCMT1234	Bacillus coagulans
TCMT1235	Clostridium sporogenes
TCMT1236	Mycobacterium bovis
TCMT1237	Mycobacterium kansasii
TCMT1238	Mycobacterium xenopi
TCMT1239	Mycobacterium marinum
TCMT1243	Aspergillus flavus
TCMT1245	Phytophthora cactorum
TCMT1246	Escherichia coli
TCMT1248	Hepatitis C virus
TCMT1249	Dengue virus 2
TCMT1251	Candida albicans
TCMT1252	Alcaligenes faecalis
TCMT1253	Penicillium chrysogenum
TCMT1255	Human immunodeficiency virus 1
TCMT1284	Penicillium expansum
TCMT1286	Bacillus cereus
TCMT1293	Vaccinia virus
TCMT1294	Human parainfluenza virus 3
TCMT1313	Human immunodeficiency virus 2
TCMT1314	Streptococcus viridans
TCMT1321	Staphylococcus hominis
TCMT1343	Staphylococcus simulans
TCMT1344	Staphylococcus sciuri
TCMT1346	Helicobacter pylori
TCMT1349	Helicobacter pylori SS1
TCMT1361	Neisseria meningitidis
TCMT1370	Prevotella melaninogenica
TCMT1382	Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393	Vibrio sp.
TCMT1408	Colletotrichum gloeosporioides
TCMT1412	Salmonella typhimurium
TCMT1438	Plasmodium falciparum
TCMT1439	Mycobacterium smegmatis
TCMT1442	Leishmania donovani
TCMT1443	Leishmania amazonensis
TCMT1444	Fusarium oxysporum
TCMT1448	Enterobacter aerogenes
TCMT1449	Influenza A virus
TCMT1454	Bacillus subtilis
TCMT1455	Mycobacterium tuberculosis H37Rv
TCMT1457	Leishmania major
TCMT1458	Filobasidiella neoformans
TCMT1462	Streptococcus mutans
TCMT1463	Mycobacterium tuberculosis
TCMT1464	Hepatitis B virus
TCMT1465	Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term	GO Name	Enriched Genes	Log10 Adjusted P-value

KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID	Enriched Genes	Log10 Adjusted P-value

Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset

Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples

Data Section	Select to Download
1. General Information of Prescription
2. Putative Targets
3. Activity & References for Filtering Putative Targets
4. GO & Pathway

TCM Prescription: Tong Zhong Ling