Prescription Description
| Prescription ID | TCMFx3712 |
| Pinyin Name | Guan Jie Zhi Tong Gao |
| Chinese Name | 关节止痛膏 |
| English Name | Guan Jie Zhi Tong Ointment |
| Function Description | 痹病 |
| Indications | Arthritis, Rheumatoid arthritis |
| Disease ICD-11 Category |
FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病，未特指的
]; FA20 [Rheumatoid arthritis, 类风湿性关节炎 ]; |
| Human Tissues Associated with Indication | SkeletalMuscle, Blood |
| Reference | CFDA |
| Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH1232 | Capsicum frutescens | 辣椒流浸膏 | TCMH1232 | ITSAL4555-14 |
| TCMH472 | Atropa belladonna | 颠茄流浸膏 | TCMH472 | AY028147 |
| TCMH191 | Mentha haplocalyx | 薄荷油 | TCMH191 | HM595443 |
| TCMH2009 | Methyl salicylatum | 水杨酸甲酯 | TCMH2009 | |
| TCMH2585 | Cinnamomum camphora | 樟脑 | TCMH2585 | SDH069-14 |
| TCMH464 | NA | 碘 | TCMH464 | |
| TCMH468 | NA | 碘化钾 | TCMH468 | |
| TCMH2385 | NA | 盐酸苯海拉明 | TCMH2385 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
| TCMT137 | CA9 | Carbonic anhydrase IX | Lyase | Q16790 |
| TCMT154 | PRKCD | Protein kinase C delta | Kinase | Q05655 |
| TCMT290 | CHRM5 | Muscarinic acetylcholine receptor M5 | GPCR | P08912 |
| TCMT291 | CHRM3 | Muscarinic acetylcholine receptor M3 | GPCR | P20309 |
| TCMT292 | CHRM1 | Muscarinic acetylcholine receptor M1 | GPCR | P11229 |
| TCMT293 | CHRM2 | Muscarinic acetylcholine receptor M2 | GPCR | P08172 |
| TCMT295 | MMP1 | Matrix metalloproteinase-1 | Hydrolase | P03956 |
| TCMT306 | MMP2 | Matrix metalloproteinase-2 | Hydrolase | P08253 |
| TCMT321 | MMP9 | Matrix metalloproteinase 9 | Hydrolase | P14780 |
| TCMT327 | TRPV1 | Vanilloid receptor | Ion channel | Q8NER1 |
| TCMT34 | CYP2D6 | Cytochrome P450 2D6 | Oxidoreductase | P10635 |
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1175 | Human immunodeficiency virus |
| TCMT1218 | Staphylococcus aureus |
| TCMT1221 | Human herpesvirus 4 |
| TCMT1246 | Escherichia coli |
| TCMT1251 | Candida albicans |
| TCMT1253 | Penicillium chrysogenum |
| TCMT1393 | Vibrio sp. |
| TCMT1438 | Plasmodium falciparum |
| TCMT1444 | Fusarium oxysporum |
| TCMT1454 | Bacillus subtilis |
| TCMT1455 | Mycobacterium tuberculosis H37Rv |
| TCMT1462 | Streptococcus mutans |
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples