Prescription Description
| Prescription ID | TCMFx3311 |
| Pinyin Name | Dian Xian San |
| Chinese Name | 癫痫散 |
| English Name | Dian Xian Powder |
| Function Description | 癫痫 |
| Indications | Epilepsy |
| Disease ICD-11 Category |
8A6Z [Epilepsy or seizures, unspecified, 癫痫或癫痫发作，未特指的
]; |
| Human Tissues Associated with Indication | Brain, Heart |
| Reference | CFDA |
| Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH2532 | Curcuma aromatica | 郁金 | TCMH2532 | ITSAF2298-14 |
| TCMH28 | Croton tiglium | 巴豆 | TCMH28 | ITSAJ4152-14 |
| TCMH1709 | Buthus martensi | 全蝎 | TCMH1709 | |
| TCMH2265 | Cyperus rotundus | 香附 | TCMH2265 | GENG1049-15 |
| TCMH2176 | Scolopendra subspinipes mutilans | 蜈蚣 | TCMH2176 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
| TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
| TCMT151 | PRKCA | Protein kinase C alpha | Kinase | P17252 |
| TCMT152 | PRKCB | Protein kinase C beta | Kinase | P05771 |
| TCMT153 | PRKCG | Protein kinase C gamma | Kinase | P05129 |
| TCMT154 | PRKCD | Protein kinase C delta | Kinase | Q05655 |
| TCMT155 | PRKCE | Protein kinase C epsilon | Kinase | Q02156 |
| TCMT156 | CYP19A1 | Cytochrome P450 19A1 | Oxidoreductase | P11511 |
| TCMT187 | AR | Androgen Receptor | Nuclear receptor | P10275 |
| TCMT193 | RELA | Nuclear factor NF-kappa-B p65 subunit | Transcription factor | Q04206 |
| TCMT194 | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | Kinase | O43318 |
| TCMT195 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | Kinase | Q02750 |
| TCMT196 | MAP2K7 | Dual specificity mitogen-activated protein kinase kinase 7 | Kinase | O14733 |
| TCMT208 | MAOA | Monoamine oxidase A | Oxidoreductase | P21397 |
| TCMT223 | AKR1B1 | Aldose reductase | Oxidoreductase | P15121 |
| TCMT230 | HSD17B3 | Estradiol 17-beta-dehydrogenase 3 | Oxidoreductase | P37058 |
| TCMT297 | FABP4 | Fatty acid binding protein adipocyte | Unclassified | P15090 |
| TCMT298 | FABP3 | Fatty acid binding protein muscle | Hydrolase | P05413 |
| TCMT301 | PTGES | Prostaglandin E synthase | Isomerase | O14684 |
| TCMT45 | APP | Beta amyloid A4 protein | Unclassified | P05067 |
| TCMT46 | F3 | Coagulation factor III | Unclassified | P13726 |
| TCMT565 | EP300 | Histone acetyltransferase p300 | Transferase | Q09472 |
| TCMT566 | NOS2 | Nitric oxide synthase, inducible | Oxidoreductase | P35228 |
| TCMT570 | ANPEP | Aminopeptidase N | Unclassified | P15144 |
| TCMT63 | PPARA | Peroxisome proliferator-activated receptor alpha | Nuclear receptor | Q07869 |
| TCMT725 | CACNA1C | Voltage-gated L-type calcium channel alpha-1C subunit | Ion channel | Q13936 |
| TCMT80 | MAPK1 | MAP kinase ERK2 | Kinase | P28482 |
| TCMT808 | FABP5 | Fatty acid binding protein epidermal | Unclassified | Q01469 |
| TCMT809 | FABP2 | Fatty acid binding protein intestinal | Unclassified | P12104 |
| TCMT810 | TLR2 | Toll-like receptor 2 | Unclassified | O60603 |
| TCMT87 | CYP2C9 | Cytochrome P450 2C9 | Oxidoreductase | P11712 |
| TCMT99 | SHBG | Testis-specific androgen-binding protein | Unclassified | P04278 |
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1215 | Pseudomonas aeruginosa PAO1 |
| TCMT1218 | Staphylococcus aureus |
| TCMT1221 | Human herpesvirus 4 |
| TCMT1224 | Proteus mirabilis |
| TCMT1226 | Klebsiella pneumoniae |
| TCMT1246 | Escherichia coli |
| TCMT1249 | Dengue virus 2 |
| TCMT1251 | Candida albicans |
| TCMT1253 | Penicillium chrysogenum |
| TCMT1255 | Human immunodeficiency virus 1 |
| TCMT1294 | Human parainfluenza virus 3 |
| TCMT1313 | Human immunodeficiency virus 2 |
| TCMT1314 | Streptococcus viridans |
| TCMT1346 | Helicobacter pylori |
| TCMT1361 | Neisseria meningitidis |
| TCMT1382 | Plasmodium falciparum (isolate K1 / Thailand) |
| TCMT1438 | Plasmodium falciparum |
| TCMT1442 | Leishmania donovani |
| TCMT1454 | Bacillus subtilis |
| TCMT1455 | Mycobacterium tuberculosis H37Rv |
| TCMT1462 | Streptococcus mutans |
| TCMT1463 | Mycobacterium tuberculosis |
| TCMT1465 | Entamoeba histolytica |
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples