Prescription Description
| Prescription ID | TCMFx1036 |
| Pinyin Name | Zi Jin Ding |
| Chinese Name | 紫金锭 |
| English Name | Zi Jin Tincture |
| Function Description | 霍乱痧胀, 暑湿温疫, 颠狂昏乱, 五绝, 暴厥, 岚瘴中恶, 水土不服, 喉风, 中毒, 鬼胎, 痈疽, 蛇犬诸伤 |
| Indications | Dampness and warmth disorder, Severe vomiting and diarrhoea disorder |
| Disease ICD-11 Category |
SE02 [Dampness and warmth disorder (TM1), 湿温 (TM1)
]; SD92 [Severe vomiting and diarrhoea disorder (TM1), 霍乱 (TM1) ]; |
| Human Tissues Associated with Indication | Skin |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH1813 | Asarum sagittarioides | 山慈菇 | TCMH1813 | ITSAI1567-14 |
| TCMH1659 | Semen euphorbiae pulveratum | 千金子霜 | TCMH1659 | ITSAM343-14 |
| TCMH1717 | Moschus moschiferus | 人工麝香 | TCMH1717 | GBMA2112-09 |
| TCMH2329 | Realgar | 雄黄 | TCMH2329 | |
| TCMH857 | Radix knoxiae | 红大戟 | TCMH857 | |
| TCMH2175 | Galla chinensis | 五倍子 | TCMH2175 | |
| TCMH2682 | Cinnabaris | 朱砂 | TCMH2682 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT156 | CYP19A1 | Cytochrome P450 19A1 | Oxidoreductase | P11511 |
| TCMT17 | POLB | DNA polymerase beta | Transferase | P06746 |
| TCMT187 | AR | Androgen Receptor | Nuclear receptor | P10275 |
| TCMT203 | G6PD | Glucose-6-phosphate 1-dehydrogenase | Oxidoreductase | P11413 |
| TCMT230 | HSD17B3 | Estradiol 17-beta-dehydrogenase 3 | Oxidoreductase | P37058 |
| TCMT236 | ESR2 | Estrogen receptor beta | Nuclear receptor | Q92731 |
| TCMT261 | DAPK1 | Death-associated protein kinase 1 | Kinase | P53355 |
| TCMT344 | AOX1 | Aldehyde oxidase | Oxidoreductase | Q06278 |
| TCMT591 | ESRRA | Estrogen-related receptor alpha | Nuclear receptor | P11474 |
| TCMT636 | POLA1 | DNA polymerase alpha subunit | Transferase | P09884 |
| TCMT807 | SLC22A12 | Solute carrier family 22 member 12 | Transporter | Q96S37 |
| TCMT82 | ESR1 | Estrogen receptor alpha | Nuclear receptor | P03372 |
| TCMT822 | FUT7 | Alpha-(1,3)-fucosyltransferase 7 | Transferase | Q11130 |
| TCMT910 | ESRRB | Estrogen-related receptor beta | Nuclear receptor | O95718 |
| TCMT974 | GPER1 | G-protein coupled estrogen receptor 1 | GPCR | Q99527 |
| TCMT99 | SHBG | Testis-specific androgen-binding protein | Unclassified | P04278 |
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1178 | Actinomyces viscosus |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1438 | Plasmodium falciparum |
| TCMT1455 | Mycobacterium tuberculosis H37Rv |
| TCMT1465 | Entamoeba histolytica |
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples