TCM Prescription: Huang Dan Gan Yan Pills



Prescription Description
Prescription IDTCMF997
Pinyin NameHuang Dan Gan Yan Wan 
Chinese Name黄疸肝炎丸
English NameHuang Dan Gan Yan Pills
Function Description黄疸, 胁痛
IndicationsHypochondrium pain disorder, Jaundice disorder, Jaundice
Disease ICD-11 Category SA00 [Hypochondrium pain disorder (TM1), 胁痛 (TM1) ];
SA01 [Jaundice disorder (TM1), 黄疸 (TM1) ];
ME10.1 [Unspecified jaundice, 未特指的黄疸 ];
Human Tissues Associated with IndicationHeart, Lung,Liver
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2494 Artemisia capillaris 茵陈蒿 TCMH2494 ITSAN1371-14
TCMH465 Bupleurum candollei 滇柴胡 TCMH465 GBVU3612-13
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH1703 Swertia mileensis 青叶胆 TCMH1703 DQ317486
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH182 Areca catechu 槟榔 TCMH182 ITSAA732-14
TCMH1695 Pericarpium citri reticulatae viride 青皮 TCMH1695
TCMH619 Citrus medica var. sarcodactylis 佛手 TCMH619 ITSAJ4647-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1297 Punta Toro virus
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1C3, APP, AR, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, DNMT1, DRD2, DRD3, ESR1, ESRRA, F3, FABP3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, KIT, MAP2K1, MMP2, MMP9, PIM1, PTGES, RELA, SRC, TERT, XDH 11.8066
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, ADRA1A, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CDK6, CHRM1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, F10, F3, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2B, HTR7, KDR, KIT, MAOA, MET, POLA1, POLB, SRC, TERT, TNKS, TNKS2, XDH 11.474
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, AKR1B1, AKR1C3, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 11.2858
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, AKR1B1, AKR1C3, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 11.2858
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, ALPL, APP, AR, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, HTR5A, IGF1R, MMP2, MMP9, POLB, PTGES, RELA, SRC, TYR 11.0739
[BP] GO:0042221 response to chemical ABCB1, ADRA1A, AKR1B1, AKR1C3, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR2A, HTR2B, HTR5A, IGF1R, KDR, KIT, MMP2, MMP9, POLB, PTGES, RELA, SRC, TERT, TYR 10.6256
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 10.3601
[BP] GO:0010033 response to organic substance ADRA1A, AKR1B1, AKR1C3, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR5A, IGF1R, KDR, KIT, MMP2, POLB, PTGES, RELA, SRC, TYR 9.8982
[BP] GO:0014070 response to organic cyclic compound AKR1C3, ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FLT3, HSD11B2, HTR5A, PTGES, RELA, SRC, TYR 9.81075
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, AKR1B1, AKR1C3, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, F10, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 9.457
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, KIT, MET, PTGES, TBXAS1 9.457
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AKR1C3, AR, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DRD2, DRD3, ESR1, F3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, RELA, TERT 9.04136
[BP] GO:0033993 response to lipid AKR1C3, ALPL, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, HTR5A, PTGES, RELA, SRC, TYR 9.04136
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, AKR1C3, APP, AR, AXL, BCL2, CYP1B1, DRD2, F10, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, KIT, MAP2K1, MAP3K7, MET, PTPN1, RELA, SRC, XDH 9.04136
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 8.84435
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, AKR1B1, AKR1C3, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CDC25B, CDK6, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, HSD17B3, HTR2A, HTR2B, HTR5A, KDR, KIT, MAP2K1, MET, MMP2, MMP9, PIM1, POLB, RELA, SIGMAR1, SRC, TERT, TNKS2, TYR 8.7682
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, KIT, MMP9, PTGES, RELA, SRC, TERT 8.65347
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BACE1, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DYRK1A, ESR1, ESR2, F10, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 8.57867
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BACE1, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DYRK1A, ESR1, ESR2, F10, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 8.42803
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DYRK1A, ESR1, F10, F3, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SRC, XDH 8.32307
[BP] GO:0009719 response to endogenous stimulus ADRA1A, AKR1B1, AKR1C3, ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, DRD1, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR5A, IGF1R, KIT, MMP2, RELA, SRC 8.25408
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AKR1C3, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSD17B3, KDR, KIT, MAP2K1, POLB, RELA, SRC, TYR 8.18013
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DRD3, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2B, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PTGES, PTPN1, RELA, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH 8.11596
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, AKR1C3, ALPL, APP, AR, AXL, BCL2, CA2, CACNA1C, CDK6, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, HSD17B3, HTR5A, KDR, KIT, MAP2K1, MMP9, PIM1, POLB, RELA, SIGMAR1, SRC, TYR 8.07859
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DRD3, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 8.06122
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, AKR1C3, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, ESRRA, F10, F3, FABP4, FLT3, HTR2A, HTR2B, HTR6, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, MMP9, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 7.76888
[BP] GO:0007187 None ADORA1, ADRA1A, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR6, HTR7 7.62877
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 7.60742
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, GBA2, HSD17B3, HTR1A, MAOA, TYR 7.55394
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1C3, APP, AR, AXL, BCL2, CA1, CA2, CACNA1C, CDK6, CHRM1, CHRM2, CHRM4, CSNK2A1, CYP1B1, DNMT1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, MMP9, PIM1, POLB, PTGES, PTPN1, RELA, SIGMAR1, SRC, TNKS, TNKS2 7.52433
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM4, DRD2, DRD3, HTR1A, HTR5A, HTR7 7.50496
[BP] GO:0042493 response to drug ABCB1, ADRA1A, AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, FABP3, HSD11B2, HTR2A, HTR2B, KDR, POLB, RELA, SRC 7.35803
[BP] GO:0009725 response to hormone ADRA1A, AKR1B1, AKR1C3, ALPL, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR5A, KIT, RELA, SRC 7.2958
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, AKR1C3, CACNA1C, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2A 7.25786
[BP] GO:0007188 None ADORA1, ADRA1A, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR7 7.24869
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADRA1A, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DRD3, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 7.24869
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1C3, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CDK6, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DRD3, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP2, MMP9, POLA1, POLB, PTGES, PTPN1, RELA, SRC, TERT, TYR 7.12094
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, HTR2A, HTR2B, KDR, SRC 7.12094
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DRD3, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2B, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, PIM1, POLA1, POLB, PTGES, PTPN1, RELA, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH 7.06401
[BP] GO:0007200 None ADRA1A, CHRM1, CHRM2, CHRM4, DRD1, DRD2, ESR1, HTR2A, HTR2B 7.05707
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.89141
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CDK6, CHRM1, CHRM4, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 6.82766
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CACNA1C, CDK6, DRD1, DRD2, DRD3, HTR2A, HTR2B, KDR, SRC, TNKS, TNKS2 6.82
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, APP, AR, AXL, BCL2, CACNA1C, CHRM1, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRB, F10, F3, FABP4, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, IGF1R, KIT, MET, MMP1, MMP2, MMP9, PIM1, RELA, SRC, TNKS2, TYR 6.67555
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AR, AURKB, BCL2, CHRM1, CHRM4, CYP1A1, ESR1, FLT3, HTR1A, KIT, MAP2K1, MET, PIM1, POLA1, SRC, TYR 6.58115
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.51147
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.51147
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.47864
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2, HSD17B3 6.33544
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AKR1C3, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2B, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIM1, PTPN1, RELA, SIGMAR1, SRC, TERT, XDH 6.21639
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, DRD3, HTR1A, MAOA, TYR 6.15232
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGES, TBXAS1 5.87121
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FUT7, GBA2, HSD17B3, HTR2B, PIM1, PTGES, TBXAS1, TYR, XDH 5.82299
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, FABP3, FABP4, FLT3, HTR2A, HTR2B, MET, POLA1, POLB, SRC, TERT 5.82187
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DRD3, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2B, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PTGES, PTPN1, RELA, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH 5.82187
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DYRK1A, FLT3, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC, TNKS 5.81977
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADRA1A, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DYRK1A, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, MMP9, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 5.74448
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, APP, AR, DRD2, FLT3, HTR2A, HTR2B, KDR, KIT, MAP2K1, MAP3K7, PTPN1, SRC, XDH 5.62682
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AKR1C3, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2B, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIM1, PTPN1, RELA, SIGMAR1, SRC, TERT, XDH 5.61292
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, AKR1C3, CSNK2A1, DRD1, DRD2, DRD3, HTR1A, MAOA 5.60373
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, APP, BACE1, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, KIT 5.55831
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, APP, BACE1, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, KIT 5.55831
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.517
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, AKR1C3, APP, AR, AURKB, BCL2, CDC25B, DNMT1, DRD1, DRD2, DRD3, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HTR2A, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 5.50575
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGES, TBXAS1 5.50013
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CACNA1C, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 5.4362
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP3, FLT3, HTR2A, HTR2B, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 5.4339
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP3, FLT3, HTR2A, HTR2B, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 5.4339
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAOA, TBXAS1, TYR, XDH 5.4339
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, APP, AR, AXL, BCL2, CA2, CA7, CACNA1C, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PTPN1, SRC, TERT 5.3969
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, DRD3, HSD11B2, HTR2A, HTR2B, KIT, MMP2, POLB, RELA, SRC, TERT, TYR 5.3969
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DRD3, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2A, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 5.39174
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DYRK1A, ESR1, ESR2, F10, F3, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 5.38588
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 5.34579
[BP] GO:0010038 response to metal ion AKR1C3, APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, KIT, MMP9, PTGES, TERT 5.33709
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGES, TBXAS1 5.30748
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 5.26549
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, AKR1C3, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DRD3, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HTR2A, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 5.22521
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AKR1C3, ALPL, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, RELA, SRC, TERT 5.21599
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, KDR, POLB, RELA, SRC 5.18735
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, ADRA1A, APP, AR, AURKB, BCL2, CDC25B, DRD2, ESR1, ESR2, F3, FLT3, HTR2A, HTR2B, KIT, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SRC, TERT, TNKS, XDH 5.1607
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PTGES, PTPN1, RELA, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH 5.16002
[BP] GO:0003018 None ADORA1, ADRA1A, CHRM1, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SRC 5.15835
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AKR1C3, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2B, IGF1R, KDR, MAP2K1, MMP9, PIM1, PTPN1, RELA, SIGMAR1, SRC, TERT, XDH 5.12661
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, KIT, SRC 5.12661
[BP] GO:0048608 reproductive structure development AKR1C3, AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSD17B3, KIT, MAP2K1, SRC 5.12661
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, DRD2, DRD3, F10, F3, KIT, MET, SRC, XDH 5.11048
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DRD3, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2A, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 4.98598
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, RELA, SRC, TERT 4.96449
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 4.95429
[BP] GO:0051716 cellular response to stimulus AKR1B1, AKR1C3, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP2, MMP9, POLA1, POLB, PTPN1, RELA, SRC, TERT 4.91795
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 4.86731
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD2, ESRRB, FLT3, HTR2A, HTR2B, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 4.85581
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DRD3, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HTR2A, HTR2B, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIM1, PTGES, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 4.82485
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, DRD3, DYRK1A, ESR1, F10, F3, FLT3, FUT7, GBA2, HTR1A, HTR2B, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, POLB, PTPN1, RELA, SRC, TNKS, TNKS2, TYR, XDH 4.82257
[BP] GO:0071310 cellular response to organic substance AKR1B1, AKR1C3, ALPL, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DNMT1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, RELA, SRC 4.81581
[BP] GO:0097746 None ADORA1, ADRA1A, CHRM1, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.80315
[BP] GO:0035296 None ADORA1, ADRA1A, CHRM1, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.80315
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, MAP3K7, PIM1, RELA, SRC 4.77756
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.76201
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, APP, AR, DRD2, FLT3, HTR2A, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, PTPN1, SRC, XDH 4.67219
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA1A, APP, AR, AXL, BCL2, CA2, CACNA1C, CDK6, CHRM1, CHRM2, CYP1B1, DRD2, DRD3, ESR1, ESRRA, ESRRB, F3, HTR2A, HTR2B, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIM1, RELA, SRC, TERT, TNKS2, XDH 4.66371
[BP] GO:0050880 None ADORA1, ADRA1A, CHRM1, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.62684
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, CSNK2A1, DNMT1, DRD2, DYRK1A, ESR1, F3, FLT3, HTR2A, HTR2B, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, RELA, SRC, XDH 4.62684
[BP] GO:0035150 None ADORA1, ADRA1A, CHRM1, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.60474
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, SRC 4.5855
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DYRK1A, FLT3, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC, TNKS 4.56635
[BP] GO:0042310 None ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 4.55219
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, SRC 4.53523
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DRD3, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PTGES, PTPN1, RELA, SIGMAR1, SRC, TERT, TNKS, TNKS2, XDH 4.51866
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD2, FLT3, HTR2A, HTR2B, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 4.4974
[BP] GO:0035265 organ growth ADRA1A, AR, BCL2, CYP19A1, ESR1 4.48615
[BP] GO:0035556 intracellular signal transduction ADRA1A, AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, DNMT1, DRD1, DRD2, DRD3, HTR2A, HTR2B, HTR5A, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, POLB, PTPN1, RELA, SRC 4.48507
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, RELA, SRC, TERT 4.47224
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, AKR1C3, APP, CA2, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, ESR1, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1, SRC 4.47102
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, APP, AR, AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, ESRRB, F3, HTR2A, HTR2B, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIM1, RELA, SRC, TERT 4.45811
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, PIM1, SRC 4.42398
[BP] GO:0003014 None ADORA1, ADRA1A, AKR1B1, AKR1C3, BCL2, DRD2, HSD11B2 4.42236
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, FABP3, FABP4, FUT7, GBA2, KIT, MET, PTGES, TBXAS1 4.40223
[BP] GO:0032845 None ADORA1, BCL2, DRD2, HTR2A, HTR2B, SRC, TNKS, TNKS2 4.38449
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, DRD2 4.36675
[BP] GO:0007154 None ADORA1, ADRA1A, AKR1C3, AR, AXL, BCL2, CACNA1C, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7 4.34375
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, DYRK1A, FLT3, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, POLB, PTPN1, SRC, TNKS, XDH 4.32332
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGES, TBXAS1 4.32332
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.32332
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.32332
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, ESR1, HTR2A, HTR2B, KIT 4.31373
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DNMT1, DRD2, DYRK1A, FLT3, HTR2A, HTR2B, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 4.30353
[BP] GO:0003013 None ADORA1, ADRA1A, CHRM1, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SRC 4.29896
[BP] GO:0050795 None ADORA1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 4.24083
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, HSD17B3, KIT, MAP2K1, SRC 4.18789
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGES, TBXAS1 4.17884
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, ALPL, APP, AR, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, ESR1, ESRRB, HSD11B2, HSD17B2, HSD17B3, KIT, MAP2K1, MMP2, MMP9, SRC 4.16328
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD1, DRD2, DRD3, ESRRB, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 4.16074
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, ESR1, HTR2A, HTR2B, KIT 4.14641
[BP] GO:1902532 negative regulation of intracellular signal transduction ADRA1A, BCL2, DRD2, DRD3, DYRK1A, ESR1, IGF1R, MET, MMP9, PTPN1, RELA, SRC, XDH 4.14292
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, RELA, SRC 4.13382
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, APP, BCL2, CA2, CA7, CACNA1C, CHRM1, DRD1, DRD2, DRD3, HTR1A, HTR2A, MMP9 4.13255
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, TERT, TNKS, XDH 4.1287
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, ADRA1A, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KIT, MAP2K1, MAP3K7, MET, MMP9, PIM1, PTPN1, RELA, SRC, TERT, TNKS, XDH 4.12276
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD1, DRD2, DRD3, ESRRB, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 4.11431
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DRD3, DYRK1A, ESR1, HTR7, KIT, SRC 4.11268
[BP] GO:0048545 response to steroid hormone AKR1C3, ALPL, AR, BCL2, CA2, FLT3, HSD11B2, RELA, SRC 4.09684
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD1, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 4.07037
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 4.07037
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, DRD1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 4.0658
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, MAOA 4.0658
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DNMT1, DRD1, DRD2, DYRK1A, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, RELA, SRC, XDH 4.04582
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, DYRK1A, FLT3, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, POLB, PTPN1, SRC, TNKS, XDH 4.00661
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 3.99856
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1, HSD17B3 3.99856
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, KIT, SRC 3.99322
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, DNMT1, DRD2, DYRK1A, ESR1, F3, FLT3, HTR2A, HTR2B, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, SRC, XDH 3.96114
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, AR, BCL2, DRD1, DRD2, DRD3, DYRK1A, ESR1, ESR2, HTR2A, IGF1R, MET, MMP9, PTPN1, RELA, SRC, TERT, XDH 3.96114
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, AR, BCL2, DRD1, DRD2, DRD3, DYRK1A, ESR1, ESR2, HTR2A, IGF1R, MET, MMP9, PTPN1, RELA, SRC, TERT, XDH 3.9423
[BP] GO:0007568 aging ADRA1A, AURKB, BCL2, CYP1A1, HTR2A, MAP2K1, POLB, RELA, TERT 3.93497
[BP] GO:0048878 chemical homeostasis ADRA1A, AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, FABP3, FABP4, HTR2A, HTR2B, MET 3.93468
[BP] GO:0051130 positive regulation of cellular component organization APP, AR, AURKB, AXL, BCL2, DNMT1, DRD2, DRD3, ESR1, IGF1R, KDR, KIT, MAP2K1, MET, MMP1, MMP9, SRC, TNKS, TNKS2 3.93468
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, DRD1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.93468
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3, GBA2 3.90909
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, AXL, BCL2, CYP1B1, MMP9, RELA, SRC 3.87125
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2 3.85965
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MMP9, PIM1, PTPN1, RELA, SRC, TERT 3.83294
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3, MAOA 3.82641
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3, MAOA 3.82641
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APP, AR, AXL, CDK6, CYP1B1, DNMT1, DRD1, ESR1, IGF1R, MMP2, MMP9, RELA, SRC 3.82641
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, DRD1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.82641
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 3.74693
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 3.74096
[BP] GO:0050801 ion homeostasis ADRA1A, APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, FABP3, HTR2A, HTR2B 3.72876
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, DYRK1A, F10, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, SRC, TNKS 3.71537
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DRD3, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HTR2A, HTR2B, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIM1, PTGES, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 3.70608
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, DNMT1, FABP3, HSD17B2, KDR, MMP2, PTGES, RELA, SRC 3.70608
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, DRD1, F10, F3, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.69404
[BP] GO:0008542 None APP, DRD1, DRD2, DRD3, KIT 3.61427
[BP] GO:0010518 positive regulation of phospholipase activity ADRA1A, ESR1, HTR2A, HTR2B, KIT 3.57843
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3 3.54834
[BP] GO:0023052 None ADORA1, ADRA1A, AR, CACNA1C, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7 3.54114
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, FLT3, HTR2A, HTR2B, KIT, MAP2K1, MAP3K7, PTPN1, SRC 3.53051
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, APP, DRD2, HTR2A, HTR2B, KDR, MAP2K1, SRC 3.53051
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, HTR2A, HTR2B, IGF1R, KIT, MAP2K1, MAP3K7, PTPN1, SRC 3.51954
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, ADRA1A, APP, AR, BCL2, CDK6, CYP1B1, DRD2, FABP3, MAP2K1, PTGES, TERT, XDH 3.51441
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 3.45804
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.44892
[BP] GO:0007632 None APP, DRD1, DRD2, DRD3, KIT 3.42523
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, APP, DRD2, HTR2A, HTR2B, KDR, MAP2K1, PTPN1, SRC 3.41144
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, ALPL, APP, AR, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, SRC 3.40776
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA1A, APP, AURKB, BCL2, CDC25B, DRD2, ESR1, F3, FLT3, HTR2A, HTR2B, KIT, MAP2K1, MAP3K7, PTPN1, SRC, TERT, TNKS, XDH 3.37791
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CACNA1C, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DRD3, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PTGES, PTPN1, RELA, SIGMAR1, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH 3.37791
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.36799
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.36799
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.36799
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.36799
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.36799
[BP] GO:0007267 None ADORA1, ADRA1A, AR, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7 3.36799
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AKR1C3, AOX1, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, FUT7, GBA2, MAOA, MMP1, MMP2, MMP9, SRC, XDH 3.3402
[BP] GO:0046686 response to cadmium ion AKR1C3, CYP1A2, KIT, MMP9, TERT 3.32814
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, AKR1C3, CYP1A1, DRD3, FABP3, FLT3, HTR2A, HTR2B, KIT, SRC 3.29976
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD1, DRD2, DRD3, KIT, RELA, TYR 3.29704
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, F10, F3, KIT, MET, SRC 3.29626
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 3.25995
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, POLB, SRC, TERT 3.22906
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.22858
[BP] GO:0010517 regulation of phospholipase activity ADRA1A, ESR1, HTR2A, HTR2B, KIT 3.22858
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CDK6, CYP19A1, DRD2, DYRK1A, ESR1, F3, FABP4, IGF1R, MAP2K1, MAP3K7, MET, MMP2, PTPN1, RELA, SRC, TERT, XDH 3.22687
[BP] GO:0007268 None CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7 3.22687
[BP] GO:0098916 None CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7 3.22687
[BP] GO:0071073 None FABP3, HTR2A, HTR2B 3.21853
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.21853
[BP] GO:0042417 None DRD1, DRD2, DRD3, MAOA 3.21729
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, PTGES 3.21568
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PTGES, TBXAS1 3.18737
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DNMT1, DRD1, DRD2, DRD3, FABP3, FLT3, HSD11B2, IGF1R, MMP2, RELA, SRC, TYR 3.17647
[BP] GO:0099536 None CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7 3.15696
[BP] GO:0099537 None CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7 3.15696
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, TNKS, TNKS2 3.15553
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 3.14819
[BP] GO:0060193 positive regulation of lipase activity ADRA1A, ESR1, HTR2A, HTR2B, KIT 3.14407
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, AR, BCL2, CDK6, CYP19A1, DRD1, DRD2, DRD3, DYRK1A, ESR1, ESR2, IGF1R, MET, MMP9, PTPN1, RELA, SRC, TERT, XDH 3.14106
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2D6 3.13885
[BP] GO:0030003 cellular cation homeostasis ADRA1A, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 3.12365
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, RELA, SRC 3.1202
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, ESR2, KIT, MAP3K7, PIM1, RELA 3.09148
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.09148
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.09148
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, HTR2A 3.09117
[BP] GO:0060402 None ADRA1A, CACNA1C, DRD2, HTR2A, HTR2B 3.09117
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, MAP2K1, POLB, TYR 3.07576
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A 3.06752
[BP] GO:0006940 None ADORA1, ADRA1A, CHRM1, CHRM2, KIT 3.06391
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, CACNA1C, DRD1, DRD2, DRD3, HTR2B, HTR5A, KDR 3.05795
[BP] GO:0055074 calcium ion homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 3.05795
[BP] GO:0006873 cellular ion homeostasis ADRA1A, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 3.03862
[BP] GO:0003008 None ADORA1, ADRA1A, AKR1B1, AKR1C3, APP, BCL2, CHRM1, CYP1B1, DRD1, DRD2, DRD3, HSD11B2, HTR1A, HTR2A, HTR2B, HTR7, KIT, SRC, TYR 3.03563
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KIT, MAP2K1, MAP3K7, PTPN1, SRC, TNKS 3.03563
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AKR1C3, APP, AR, DNMT1, DRD1, ESR1, FLT3, IGF1R, KIT, MMP2, RELA, SRC 3.03428
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KIT, MAP2K1, MAP3K7, PTPN1, SRC 3.03428
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, FLT3, HTR2A, HTR2B, KIT, MAP2K1, MAP3K7, PTPN1, SRC, TNKS 3.02294
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 3.02095
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, DRD2, DRD3, TNKS2 3.01507
[BP] GO:0002031 None DRD2, DRD3, HTR2B 2.98518
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 2.98518
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.98518
[BP] GO:0019371 None AKR1C3, PTGES, TBXAS1 2.98518
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MET, RELA, SRC, TERT, TNKS, TNKS2 2.98098
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1, HSD17B3 2.9608
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, MET 2.94203
[BP] GO:0008306 None APP, DRD1, DRD2, DRD3, KIT 2.90555
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PTPN1, SRC, TNKS 2.90349
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, HTR6 2.88657
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DNMT1, DRD1, DRD2, DRD3, FABP3, FLT3, HSD11B2, IGF1R, MMP2, RELA, SRC, TYR 2.86595
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.86573
[BP] GO:0016488 None AKR1B10, AKR1C3 2.86573
[BP] GO:0016487 None AKR1B10, AKR1C3 2.86573
[BP] GO:0016107 None AKR1B10, AKR1C3 2.86573
[BP] GO:0009115 None AOX1, XDH 2.86573
[BP] GO:0006714 None AKR1B10, AKR1C3 2.86573
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, KIT, SRC 2.85973
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, FLT3, HTR2A, HTR2B, KIT, MAP2K1, MAP3K7, PTPN1, SRC 2.84944
[BP] GO:0009314 response to radiation APP, AURKB, BCL2, DRD1, DRD2, DRD3, KIT, POLB, RELA, TYR 2.84062
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CA7, CACNA1C, CHRM1, CYP19A1, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, MAP2K1, MMP9, PTPN1, SRC, TERT 2.83096
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.82653
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, DNMT1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, HTR2A, IGF1R, MAP2K1, MET, PTPN1, RELA, SRC, TERT, TNKS, TNKS2 2.81587
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 2.81403
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, SRC, TERT 2.81142
[BP] GO:0051952 None ADORA1, DRD1, DRD2, DRD3, HTR2A 2.7945
[BP] GO:0060401 None ADRA1A, CACNA1C, DRD2, HTR2A, HTR2B 2.7945
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.7945
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.7945
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 2.7945
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APP, AXL, BCL2, CYP1B1, MMP9, RELA, SRC 2.77997
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, CYP2D6, MET, MMP9, SRC, TERT, TNKS 2.77997
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.77997
[BP] GO:0055080 cation homeostasis ADRA1A, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.76413
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CHRM1, CYP19A1, DRD1, DRD2, DRD3, HTR2B, SRC, TERT 2.7514
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, DYRK1A, MAP2K1, TNKS 2.75103
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, SRC 2.75047
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KIT, MAP2K1, MAP3K7, PTPN1, SRC 2.74709
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, RELA, SRC 2.73802
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, SRC, TERT 2.73724
[BP] GO:0048869 cellular developmental process ACHE, AKR1C3, ALPL, APP, AR, AXL, BCL2, CDC25B, CDK6, CYP1A1, DRD1, DRD2, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, HTR2B, KDR, KIT, MAP2K1, MET, MMP2, MMP9, SRC, TERT 2.72328
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, FLT3, HTR2A, HTR2B, KIT, MAP2K1, MAP3K7, PTPN1, SRC 2.71355
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AKR1C3, APP, AR, AURKB, BCL2, CSNK2A1, CYP2D6, DNMT1, DRD2, DRD3, DYRK1A, ESR1, ESR2, ESRRA, FABP4, HTR2B, IGF1R, KDR, MAP2K1, MET, MMP9, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 2.71221
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.71221
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.71221
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.71221
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DRD1, DYRK1A, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, PIM1, POLB, PTPN1, SRC, TNKS, TNKS2 2.69436
[BP] GO:0050890 None ADORA1, APP, CHRM1, DRD1, DRD2, DRD3, HTR2A, KIT 2.69206
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CACNA1C, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DRD3, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PTGES, PTPN1, RELA, SIGMAR1, SRC, TERT, TNKS, TNKS2, XDH 2.67976
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, HSD11B2, HTR1A, KIT, MAP2K1, MAP3K7, MMP2, MMP9, POLA1, POLB, PTGES, PTPN1, RELA, SRC, TERT 2.66643
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3 2.66291
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, IGF1R, MAP2K1, MET, RELA, SRC, TERT, TNKS, TNKS2 2.64362
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, FLT3, HTR2A, HTR2B, KIT, MAP2K1, MAP3K7, PTPN1, SRC 2.64362
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.6298
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.6298
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.62953
[BP] GO:0051781 None AURKB, CDC25B, DRD2, DRD3, HTR2B 2.62422
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, SRC, TERT 2.61278
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, DYRK1A, MAP2K1, TNKS 2.60517
[BP] GO:0060191 regulation of lipase activity ADRA1A, ESR1, HTR2A, HTR2B, KIT 2.60517
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, DRD1, KDR, RELA, SRC 2.59974
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, DRD2, DRD3, HTR2A, MMP9 2.58785
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DRD1, DYRK1A, ESR1, F10, F3, FLT3, FUT7, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, POLB, PTPN1, RELA, SRC, TNKS, TNKS2 2.57497
[BP] GO:1903522 None ADORA1, ADORA3, ADRA1A, CACNA1C, CHRM1, CHRM2, DRD2, HTR2A 2.57074
[BP] GO:0051302 None AURKB, CDC25B, DRD2, DRD3, ESRRB, HTR2B 2.56052
[BP] GO:0071071 None FABP3, HTR2A, HTR2B 2.56052
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.56052
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.56052
[BP] GO:0070920 None ESR1, MAP2K1, TERT 2.56052
[BP] GO:0032225 None DRD1, DRD2, DRD3 2.56052
[BP] GO:0051094 positive regulation of developmental process APP, AR, AXL, BCL2, CA2, CYP1B1, DRD2, ESRRB, F3, HTR2A, KDR, KIT, MAP2K1, PIM1, RELA, SRC, TERT 2.55909
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, MMP9, PTPN1, RELA, SRC, TERT 2.55036
[BP] GO:0009605 response to external stimulus ADORA1, ADRA1A, AKR1C3, ALPL, AXL, BCL2, CDK6, CHRM2, CYP1A1, CYP1A2, DRD3, HSD11B2, HTR2A, KIT, PTGES, RELA, SRC, TYR 2.53629
[BP] GO:2001023 None DRD1, DRD2, DRD3, HTR2A, MET 2.52493
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DRD3, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FLT3, FUT7, GBA2, HTR1A, HTR2B, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, TYR, XDH 2.52486
[BP] GO:0019725 cellular homeostasis ADRA1A, APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B, POLA1 2.51212
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.48649
[BP] GO:0019933 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.48417
[BP] GO:0008217 None ADORA1, ADRA1A, AR, DRD2, DRD3, HSD11B2 2.4804
[BP] GO:0046110 None AOX1, XDH 2.4804
[BP] GO:0060160 None DRD2, DRD3 2.4804
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.4804
[BP] GO:0016095 None AKR1B10, AKR1C3 2.4804
[BP] GO:0032787 None AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GBA2, PTGES, TBXAS1 2.46269
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA1A, APP, AR, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTPN1, RELA, SRC, XDH 2.44012
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.42202
[BP] GO:0006875 cellular metal ion homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.42202
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CACNA1C, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DRD3, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PTGES, PTPN1, RELA, SIGMAR1, SRC, TERT, TNKS, TNKS2, XDH 2.41555
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA1A, AKR1C3, APP, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DRD3, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIM1, POLA1, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 2.40951
[BP] GO:0031960 response to corticosteroid AKR1C3, ALPL, BCL2, FLT3, HSD11B2, SRC 2.39407
[BP] GO:0009968 negative regulation of signal transduction ADRA1A, AR, BCL2, DRD2, DRD3, DYRK1A, ESR1, ESR2, IGF1R, MET, MMP9, PTPN1, RELA, SRC, TERT, XDH 2.36326
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.35589
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.35589
[BP] GO:0050730 None ADORA1, APP, FLT3, HTR2A, KIT, PTPN1, SRC 2.33109
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 2.32819
[BP] GO:0019935 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.31127
[BP] GO:0006937 None ADORA1, ADRA1A, CACNA1C, CHRM1, CHRM2, KIT 2.31027
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, FLT3, HTR2A, HTR2B, IGF1R, KIT, MAP2K1, MAP3K7, PTPN1, SRC 2.30275
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.29504
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.29241
[BP] GO:0006464 cellular protein modification process ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DRD1, DYRK1A, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, POLB, PTPN1, SRC, TNKS, TNKS2 2.27474
[BP] GO:0036211 protein modification process ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DRD1, DYRK1A, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, POLB, PTPN1, SRC, TNKS, TNKS2 2.27474
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CHRM4, CSNK2A1, DRD2, F3, FLT3, IGF1R, KDR, KIT, MAP3K7, MET, MMP2, MMP9, PTPN1, RELA, SRC, TNKS, TNKS2 2.27463
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DRD1, DYRK1A, SRC, TNKS 2.26171
[BP] GO:2001237 negative regulation of extrinsic apoptotic signaling pathway AR, BCL2, RELA, SRC, TERT 2.26171
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.23766
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.23766
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR2B 2.23732
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, SRC 2.23716
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, MAP2K1, RELA, TYR 2.22373
[BP] GO:0051091 positive regulation of DNA binding transcription factor activity APP, AR, ESR1, ESR2, KIT, MAP3K7, RELA 2.21774
[BP] GO:0070213 None TNKS, TNKS2 2.21774
[BP] GO:0006145 None AOX1, XDH 2.21774
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.21774
[BP] GO:0031324 negative regulation of cellular metabolic process AKR1C3, APP, AR, AURKB, BCL2, CSNK2A1, CYP2D6, DNMT1, DRD2, DRD3, DYRK1A, ESR1, ESR2, ESRRA, FABP4, HTR2B, IGF1R, MET, MMP9, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 2.21756
[BP] GO:0044057 None ADORA1, ADORA3, ADRA1A, CACNA1C, CHRM1, CHRM2, DRD2, DRD3, HTR2A, KIT 2.21342
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.1893
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.1893
[BP] GO:0008406 gonad development AKR1C3, BCL2, CYP19A1, ESR1, KIT 2.18236
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ADRA1A, CACNA1C, DRD1, DRD2, ESR1, HTR2A, HTR2B 2.17167
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA1A, AKR1C3, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DRD3, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIM1, POLA1, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 2.17093
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, HTR2A, KIT, PTPN1, SRC 2.17093
[BP] GO:0044242 None AKR1B10, AKR1C3, CYP1B1, FABP3, FABP4, GBA2 2.17093
[BP] GO:0040007 None ADRA1A, APP, AR, BCL2, CYP19A1, ESR1, SRC, TNKS2 2.14159
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, HTR2A 2.14159
[BP] GO:0095500 None CHRM1, CHRM2, CHRM4 2.14159
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.14159
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.14159
[BP] GO:1903831 None CHRM1, CHRM2, CHRM4 2.14159
[BP] GO:0051704 multi-organism process APP, AXL, BCL2, CDK6, CHRM2, CYP1A1, DRD3, DYRK1A, HSD11B2, HTR2A, KDR, MAP2K1, MET, MMP1, POLA1, RELA, SRC 2.13593
[BP] GO:0009991 response to extracellular stimulus AKR1C3, ALPL, AXL, BCL2, CYP1A1, HSD11B2, RELA, SRC, TYR 2.13506
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.11685
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, RELA, SRC 2.113
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, HTR1A, MAOA 2.11052
[BP] GO:0051282 None CACNA1C, DRD1, DRD2, HTR2A, HTR2B 2.10527
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, RELA 2.0935
[BP] GO:0007202 None ADRA1A, HTR2A, HTR2B 2.0935
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.0935
[BP] GO:0034762 None ABCB1, APP, BCL2, CA2, CACNA1C, DRD1, DRD2, DRD3, MMP9 2.09039
[BP] GO:0060341 regulation of cellular localization APP, AR, BCL2, CACNA1C, CHRM1, CSNK2A1, DRD1, DRD2, DRD3, MAP2K1, PTPN1, SRC, TERT 2.08102
[BP] GO:0055065 metal ion homeostasis ADRA1A, APP, BCL2, CACNA1C, DRD1, DRD2, DRD3, ESR1, HTR2A, HTR2B 2.06685
[BP] GO:0043412 macromolecule modification ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DNMT1, DRD1, DYRK1A, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, POLB, PTPN1, SRC, TNKS, TNKS2 2.04665
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DRD1, DYRK1A, SRC, TNKS 2.04497
[BP] GO:0048169 None APP, DRD2, KIT 2.04497
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AKR1C3, AOX1, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, FUT7, GBA2, MAOA, XDH 2.04356
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, DRD3, MAP2K1, PIM1, TERT, TNKS 2.04013
[BP] GO:0021853 None DRD1, DRD2 2.04013
[BP] GO:0043696 None CDK6, ESRRB 2.04013
[BP] GO:0043697 None CDK6, ESRRB 2.04013
[BP] GO:0010641 None F3, SRC 2.04013
[BP] GO:0090325 None DRD2, DRD3 2.04013
[BP] GO:0007598 None F10, F3 2.04013
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.04013
[BP] GO:1904936 None DRD1, DRD2 2.04013
[BP] GO:0042321 None ADORA1, DRD2 2.04013
[BP] GO:0010513 None HTR2A, HTR2B 2.04013
[BP] GO:0003012 None ADORA1, ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 2.04013
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.0327
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, FUT7, HTR2B, HTR6, KDR, KIT, MAP2K1, MET, MMP1, MMP9, SRC 2.02132
[BP] GO:0071396 cellular response to lipid AKR1C3, AR, AXL, CDK6, ESR1, FLT3, RELA, SRC 2.01286
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.01286
[BP] GO:0001975 None DRD1, DRD2, DRD3 2.01286
[BP] GO:0006081 None AKR1B10, AKR1C3, CYP1B1, RELA 2.01286
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, RELA 2.01286
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA1A, AKR1C3, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DRD3, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIM1, POLA1, PTPN1, RELA, SRC, TERT, TNKS, TNKS2, XDH 2.01286
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, ESR1, F3, FABP4, KDR, MAP2K1, MET, RELA 2.00673
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, APP, AXL, BACE1, CA4, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, F10, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 6.50636
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ALOX5, ALPL, APP, AR, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, F10, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP2, PIM1, PTGES, PTPN1, SIGMAR1, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR 6.5012
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ALPL, APP, AR, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM4, CSNK2A1, DRD1, DRD2, DRD3, ESR1, F10, F3, FLT3, GBA2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, PIM1, PTPN1, SRC, TERT 5.63288
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, APP, AXL, BACE1, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 5.03277
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ADRA1A, APP, AXL, BACE1, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, F10, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, SIGMAR1, SRC 4.79761
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM4, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, F10, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAOA, MET, PTGES, PTPN1, SIGMAR1, SRC, TBXAS1, TYR 4.3121
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, F10, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, PTPN1, SIGMAR1, TBXAS1 3.93468
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APP, AR, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA7, CACNA1C, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR2A, HTR5A, KDR, KIT, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, PIM1, POLA1, PTGES, PTPN1, RELA, SIGMAR1, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH 3.59125
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.36799
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, GBA2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, SIGMAR1, TBXAS1 2.94559
[CC] GO:0031224 None ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ALPL, APP, AXL, BACE1, CA12, CA14, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, ESR1, F10, F3, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAOA, MET, PTGES, SIGMAR1, TBXAS1, TYR 2.94203
[CC] GO:0005783 None ADORA1, APP, BCL2, CA4, CYP19A1, CYP2D6, FLT3, GBA2, HSD17B3, HTR5A, KDR, MAP2K1, PTPN1, SIGMAR1, XDH 2.84588
[CC] GO:0098590 plasma membrane region ABCB1, ADORA1, ADRA1A, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, DRD1, DRD2, HTR2A, MET, SIGMAR1, SRC 2.69206
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, AKR1C3, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DRD3, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B3, HTR2A, HTR5A, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, PIM1, POLA1, POLB, PTPN1, RELA, SHBG, SIGMAR1, SRC, TERT, TNKS, TNKS2, TYR, XDH 2.62422
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, AKR1C3, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA9, CACNA1C, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DRD3, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B3, HTR2A, HTR5A, HTR6, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, PIM1, POLA1, POLB, PTPN1, RELA, SHBG, SIGMAR1, SRC, TERT, TNKS, TNKS2, TYR, XDH 2.52486
[CC] GO:0031233 None CA4, F10, F3 2.29504
[CC] GO:0016021 None ABCB1, ADORA1, ADORA3, ADRA1A, ALPL, APP, AXL, BACE1, CA12, CA14, CA9, CACNA1C, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, ESR1, F3, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAOA, MET, PTGES, SIGMAR1, TBXAS1, TYR 2.20578
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DRD3, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PTGES, PTPN1, RELA, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH 11.8066
[MF] GO:0008227 None ADRA1A, CHRM1, CHRM2, CHRM4, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 11.2858
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PTPN1, TBXAS1, TNKS, TYR, XDH 11.2858
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DYRK1A, F10, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PTGES, PTPN1, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH 10.2806
[MF] GO:0030594 None CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 9.8982
[MF] GO:0099528 None CHRM1, CHRM2, CHRM4, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 9.8982
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.56625
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, KIT, MAP3K7, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PTPN1, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH 8.42803
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, AR, AXL, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, SIGMAR1 8.30686
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, AR, AXL, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, SIGMAR1 7.62877
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 7.61304
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, AR, AXL, CDK6, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, SIGMAR1 7.61237
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, AR, AXL, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, SIGMAR1 7.26397
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DYRK1A, FLT3, HTR2A, HTR2B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SIGMAR1, SRC 6.98092
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAOA, TBXAS1, TYR, XDH 6.67555
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, XDH 6.65716
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.56325
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.56325
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.51147
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.51147
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 6.27273
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.21639
[MF] GO:0016229 steroid dehydrogenase activity AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.02644
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, SHBG 5.82749
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.82482
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, AXL, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, SIGMAR1 5.81977
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, AXL, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, SIGMAR1 5.81977
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1, TYR 5.55831
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1, XDH 5.05764
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.00305
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.91795
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.76735
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, CA9, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PTPN1, TNKS 4.69475
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 4.693
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, SRC 4.67125
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD11B2, HSD17B1, POLA1, PTGES, SRC, TBXAS1, XDH 4.42131
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.31373
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1, TYR 4.17884
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, ESR1, ESR2, ESRRA, ESRRB, F10, KIT, MAP3K7, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PTPN1, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH 4.16363
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 3.99856
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC 3.82776
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 3.79187
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, AOX1, XDH 3.78054
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, CHRM1, CHRM2, CHRM4, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 3.74693
[MF] GO:0047035 testosterone dehydrogenase (NAD+) activity AKR1C3, HSD17B2, HSD17B3 3.74693
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 3.74083
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, SRC, TBXAS1 3.72567
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 3.72333
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, POLA1, POLB, SRC, TERT 3.58858
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB 3.57843
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB 3.57843
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, SRC, TBXAS1 3.53392
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB 3.22858
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, AOX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DRD3, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, POLA1, POLB, PTPN1, RELA, SHBG, SRC, TBXAS1, TERT, XDH 3.12825
[MF] GO:0008289 lipid binding AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, SHBG 3.06773
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC 3.05795
[MF] GO:0004952 None DRD1, DRD2, DRD3 2.87414
[MF] GO:0045550 None AKR1B10, AKR1C3 2.86573
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.86573
[MF] GO:0003845 None HSD11B1, HSD11B2 2.86573
[MF] GO:0035240 None DRD1, DRD2, DRD3 2.7945
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC 2.71221
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, BCL2, CSNK2A1, DRD2, DYRK1A, ESR1, ESR2, FLT3, IGF1R, KDR, KIT, MAP3K7, MET, MMP9, RELA, TERT, TYR, XDH 2.68603
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, SHBG 2.60517
[MF] GO:0047718 None AKR1B10, AKR1C3 2.4804
[MF] GO:0047045 None AKR1C3, HSD17B3 2.4804
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.42202
[MF] GO:1901338 None DRD1, DRD2, DRD3 2.29504
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.21774
[MF] GO:0005497 None AR, SHBG 2.21774
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.18236
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.04013
[MF] GO:0003674 molecular_function ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DRD1, DRD2, DRD3, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PTGES, PTPN1, RELA, SHBG, SIGMAR1, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR, XDH 2.02132
[MF] GO:0004033 None AKR1B1, AKR1B10, AKR1C3 2.01286


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR6, MAP2K1, HTR7, MAOA, CYP2D6, ALOX5, HTR2B, HTR1A, CACNA1C, HTR2A, HTR5A 11.1644
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, AKR1C3, CYP1B1, CYP19A1 11.1644
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM1, CHRM4, HTR2B, HTR1A, HTR2A, HTR5A, ADRA1A, HTR6, HTR7, ADORA3, ADORA1, DRD1, DRD2, DRD3 10.2737
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, AKR1C3, CYP1B1, CYP19A1, IGF1R 8.7657
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.5429
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6, HTR7, CHRM1, HTR2B, CACNA1C, HTR2A, DRD1, HTR5A, ADRA1A 6.691
Metabolic pathways_Homo sapiens_hsa01100 DNMT1, MAOA, HSD17B3, AKR1C3, AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, POLA1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, PTGES 6.4685
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HTR6, MAP2K1, CHRM1, ADORA1, HTR1A, CACNA1C, DRD1, DRD2, RELA 6.3988
Pathways in cancer_Homo sapiens_hsa05200 AR, MAP2K1, CDK6, FLT3, MMP1, MMP2, KIT, BCL2, MMP9, MET, RELA, IGF1R 5.4681
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, MAP2K1, CHRM1, CHRM4, BCL2, CACNA1C 4.9686
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, DNMT1, CDK6, ABCB1, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 4.9165
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, MAP2K1, CDK6, CHRM1, KIT, KDR, BCL2, MET, RELA, IGF1R 4.5388
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MAP3K7, MET, IGF1R 4.902
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.4699
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 4.902
Gap junction_Homo sapiens_hsa04540 MAP2K1, SRC, HTR2B, HTR2A, DRD1, DRD2 4.5388
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, SRC, MMP2, MMP9, ESR1, ESR2 4.3052
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9 4.8959
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, FLT3, KIT, PIM1, RELA 4.3052
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, SRC, ESR1, ESR2, RELA 3.8259
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, SRC, KIT, KDR, DRD2, MET, IGF1R 3.4719
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, CDK6, SRC, BCL2, MMP9, RELA 3.4584
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, HTR7, KIT, KDR, MET, RELA, IGF1R 3.3437
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, BCL2, RELA, IGF1R 3.4584
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2D6, CYP1A2, CYP1A1, CYP1B1 3.8179
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3, RELA 3.247
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, ADORA3, BCL2, ADORA1, RELA 2.9363
Focal adhesion_Homo sapiens_hsa04510 MAP2K1, SRC, KDR, BCL2, MET, IGF1R 2.8477
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, CACNA1C, DRD1, DRD2, DRD3 2.8477
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1, AKR1C3, PTGES 2.9788
Cocaine addiction_Homo sapiens_hsa05030 MAOA, DRD1, DRD2, RELA 3.3437
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, FLT3, KIT, MET 2.8925
Melanoma_Homo sapiens_hsa05218 MAP2K1, CDK6, MET, IGF1R 2.8477
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, ADORA3, ADORA1, CACNA1C, ADRA1A 2.4068
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP2D6, CYP1A2, AOX1 2.8567
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, MMP2, CACNA1C 2.4731
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.2827
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, BCL2, RELA, IGF1R 2.3049
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, MMP9, MAP3K7, RELA 2.2198
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, MAP3K7, RELA 2.4489
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1 2.6207
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, MAP2K1, CHRM1, SRC, CHRM4 1.9931
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, MAP3K7, RELA 2.1178
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, MAP3K7, RELA 1.9473
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, CACNA1C, MAP3K7, RELA, CDC25B 1.7552
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 1.7349
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA, DRD1, DRD2 1.6087
Glioma_Homo sapiens_hsa05214 MAP2K1, CDK6, IGF1R 1.9485
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, SRC, KDR 1.9991
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, MAP3K7, RELA 1.4843
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, CDK6, RELA 1.9473
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, CDK6, RELA 1.8573
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, CDK6, SRC, RELA 1.4692
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, HTR2A 1.5699
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, CACNA1C, DRD1 1.9374
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, CDC25B, IGF1R 1.5699
Melanogenesis_Homo sapiens_hsa04916 MAP2K1, KIT, TYR 1.5528
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 1.9485
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2, RELA 1.6897
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, MAP3K7, RELA 1.518
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, MAP3K7, RELA 1.5043
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, RELA 1.9278
Apoptosis_Homo sapiens_hsa04210 MAP2K1, BCL2, RELA 1.2397
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, BCL2, RELA 1.3915
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 MAP2K1, SRC, ESR1 1.3986
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.3691
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, MAP3K7, RELA 1.3003
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C, ADRA1A 1.3915
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1 1.9179
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, ESRRB, IGF1R 1.2325
AMPK signaling pathway_Homo sapiens_hsa04152 MAP3K7, ADRA1A, IGF1R 1.3657
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.1962
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, CACNA1C, ADRA1A 1.2118
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.1739
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, SRC, CACNA1C 1.1739
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP, CACNA1C 1.1297
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2783
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2, RELA 1.0863
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.0582
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 RELA 0.3097
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, SRC, RELA 1.0511
HTLV-I infection_Homo sapiens_hsa05166 POLB, TERT, RELA 0.7838
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1 0.3423
Hepatitis C_Homo sapiens_hsa05160 RELA 0.3447
Axon guidance_Homo sapiens_hsa04360 MET 0.3571
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.7948
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.6218
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.7361
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, IGF1R 0.7547
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, MAP2K1 0.7411
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7411
Influenza A_Homo sapiens_hsa05164 MAP2K1, RELA 0.6218
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.7867
Insulin resistance_Homo sapiens_hsa04931 PTPN1, RELA 0.8661
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8116
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.3903
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, TYR 2.6187
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, MAP3K7 0.7361
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1, KIT 0.7298
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 RELA 0.4166
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4157
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1 0.4241
Amoebiasis_Homo sapiens_hsa05146 RELA 0.4241
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C 0.4241
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4353
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1 0.4377
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4343
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.4353
ErbB signaling pathway_Homo sapiens_hsa04012 MAP2K1, SRC 1.0041
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 RELA, IGF1R 0.9654
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4467
Salivary secretion_Homo sapiens_hsa04970 ADRA1A 0.4467
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.9863
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.4467
Taste transduction_Homo sapiens_hsa04742 HTR1A, CACNA1C 1.0362
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4467
Salmonella infection_Homo sapiens_hsa05132 RELA 0.4525
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.454
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.0037
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.0037
Peroxisome_Homo sapiens_hsa04146 XDH 0.4599
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, RELA 1.1103
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4633
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0673
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4599
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.4743
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.2325
Leishmaniasis_Homo sapiens_hsa05140 MAP3K7, RELA 1.1103
Pertussis_Homo sapiens_hsa05133 RELA 0.4859
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4881
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.0617
Long-term depression_Homo sapiens_hsa04730 MAP2K1, IGF1R 1.2036
Long-term potentiation_Homo sapiens_hsa04720 MAP2K1, CACNA1C 1.1669
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1, CDK6 1.2325
Adipocytokine signaling pathway_Homo sapiens_hsa04920 RELA 0.5031
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.1739
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.4881
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1 0.5082
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, MET 1.1669
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.123
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.1297
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1, BCL2 1.1875
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5056
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.229
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.1695
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2118
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5252
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.5252
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RELA 0.5222
Legionellosis_Homo sapiens_hsa05134 RELA 0.5771
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1 0.5957
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6003
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.605
Malaria_Homo sapiens_hsa05144 MET 0.6099
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.6149
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6171
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6149
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6227
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6194
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6171
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6243
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.6218
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.6655
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5827
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.518
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6588
Prion diseases_Homo sapiens_hsa05020 MAP2K1 0.7025
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.7513
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1 0.7662
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7361
DNA replication_Homo sapiens_hsa03030 POLA1 0.6944
Base excision repair_Homo sapiens_hsa03410 POLB 0.7228
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7513
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.819
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7513
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7744
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7662
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.7948
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.9201
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9897
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.9363
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.229


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)