TCM Prescription: Ling Lian Hua Granules



Prescription Description
Prescription IDTCMF97
Pinyin NameLing Lian Hua Ke Li
Chinese Name灵莲花颗粒
English NameLing Lian Hua Granules
Function Description绝经期综合征
IndicationsMenopausal and perimenopausal disorder
Disease ICD-11 Category GA30 [Menopausal or certain specified perimenopausal disorders, 绝经期或某些特指的围绝经期疾患 ];
Human Tissues Associated with IndicationUterus
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1289 NA 灵菌粉 TCMH1289
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH1597 Ligustrum lucidum 女贞子 TCMH1597 ITSAM2109-14
TCMH1503 Eclipta prostrata 墨旱莲 TCMH1503 ITSAP4516-14
TCMH62 Lilium brownii 百合 TCMH62 ITSAO2415-14
TCMH1466 Rosa rugosa 玫瑰花 TCMH1466 ITSAJ4480-14
TCMH2473 Leonurus japonicus 益母草 TCMH2473 ITSAN1807-14
TCMH2554 Polygala tenuifolia 远志 TCMH2554 MF096619
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT281 DPP4 Dipeptidyl peptidase IV Unclassified P27487
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT718 TXN2 Thioredoxin, mitochondrial Unclassified Q99757
TCMT719 TXN Thioredoxin Unclassified P10599
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MCL1, MMP2, PPARA, RORC, SMAD3, SRC, TEK, TYR 10.866
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MCL1, MMP2, MMP9, PPARA, RORC, SMAD3, SRC, TEK, TERT, TYR 10.866
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DUSP3, DYRK1A, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP2, NUAK1, PIM1, PPARA, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 9.95287
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DUSP3, DYRK1A, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 9.90208
[BP] GO:0010647 positive regulation of cell communication AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, KIT, MCL1, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 9.68962
[BP] GO:0023056 positive regulation of signaling AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, KIT, MCL1, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 9.68958
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, FABP3, HMGCR, HSD17B2, IGF1R, INSR, MMP2, MMP9, PPARA, RORC, SRC, TEK, TYR 9.54315
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, KIT, MCL1, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT 9.38021
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, KIT, MCL1, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT 9.17738
[BP] GO:0010941 regulation of cell death AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, HMGCR, HSPA1A, IGF1R, KDR, KIT, MCL1, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 9.04851
[BP] GO:0043067 regulation of programmed cell death AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, HMGCR, HSPA1A, IGF1R, KDR, KIT, MCL1, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 8.94175
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, F10, FABP3, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 8.64285
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, KIT, MMP9, SRC, TERT 8.62509
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, PIM1, SRC, TEK 8.61075
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, EGFR, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B2, INSR, KDR, KIT, MCL1, MET, MMP2, MMP9, PIM1, PPARA, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR 8.59419
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, EGFR, FABP3, FLT3, IGF1R, INSR, KIT, MMP2, PPARA, SMAD3, SRC, TEK 8.37686
[BP] GO:0042127 regulation of cell proliferation AKR1B1, APP, BCL2, CDC25B, CSNK2A1, CYP1B1, DNMT1, EGFR, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, NUAK1, PIM1, SMAD3, SRC, TEK, TERT, XDH 8.37686
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, F10, FABP3, FABP4, FLT3, GPR35, HMGCR, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, KIT, MCL1, MET, PPARA, SMAD3, SRC, TEK, TERT, XDH 8.37686
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, F10, FABP3, FABP4, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 8.37013
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, F10, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MCL1, MET, MMP12, MMP9, NUAK1, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH 8.31629
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, KIT, MCL1, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.31629
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, DYRK1A, EGFR, F10, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MCL1, MET, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 8.25851
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, F10, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MCL1, MET, MMP12, MMP9, NUAK1, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH 8.20216
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, FUT7, HMGCR, HSD17B1, HSD17B2, KIT, MET, PPARA 7.74778
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 7.72698
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MCL1, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT 7.72698
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, RORC, SMAD3, SRC, TERT 7.72698
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 7.69535
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, APP, AXL, BCL2, CYP1B1, EGFR, F10, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, KIT, MCL1, MET, PTPN1, SRC, TEK, XDH 7.69535
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MCL1, MMP2, MMP9, NUAK1, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A 7.65417
[BP] GO:0042981 regulation of apoptotic process AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MCL1, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 7.65417
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PTPN1, PTPRS, SRC, TEK, XDH 7.64485
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, GLO1, HMGCR, HSPA1A, PIM1, PPARA, TYR, XDH 7.31485
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PTPN1, PTPRS, SRC, TEK, XDH 7.22051
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.21794
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DUSP3, DYRK1A, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 7.21794
[BP] GO:0080134 regulation of response to stress ABCB1, APP, CYP19A1, DUSP3, DYRK1A, EGFR, FABP4, HMGCR, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP2, NUAK1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH 7.14717
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, EGFR, F10, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK, TERT 7.0667
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, EGFR, F10, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK, TERT 6.87388
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DUSP3, DYRK1A, EGFR, F10, FLT3, FUT7, GLO1, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TOP2A, TYR, XDH 6.85292
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.80348
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, KIT, PPARA, SRC, TEK 6.77474
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, EGFR, F10, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK, TERT 6.75021
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, FABP4, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, KIT, MCL1, MET, MMP12, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.74862
[BP] GO:0030334 regulation of cell migration APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK, TERT 6.73434
[BP] GO:0050896 response to stimulus ABCB1, ACHE, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, F10, FABP3, FABP4, FLT3, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MCL1, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR 6.64471
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD17B1, HSD17B2 6.64471
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, EGFR, F10, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK, TERT 6.59762
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DUSP3, DYRK1A, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 6.42596
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD17B2, INSR, KDR, KIT, PPARA, PTPRS, SMAD3, SRC, TEK, TYR 6.42044
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 6.3987
[BP] GO:0032879 regulation of localization ABCB1, ACHE, APEX1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, TERT 6.37919
[BP] GO:2000145 regulation of cell motility APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK, TERT 6.37919
[BP] GO:0048583 regulation of response to stimulus ABCB1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, F10, FABP4, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MCL1, MET, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH 6.33247
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, RORC, SRC, TEK, TYR 6.2744
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1B1, DNMT1, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MMP2, RORC, SMAD3, SRC 6.2744
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, GLO1, GPR35, HMGCR, HSPA1A, IGF1R, KDR, KIT, MCL1, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 6.19485
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.18003
[BP] GO:0009966 regulation of signal transduction AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, DYRK1A, EGFR, F10, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MCL1, MET, MMP12, MMP9, NUAK1, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH 6.15648
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, HMGCR, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, PIM1, TEK, TERT 5.95662
[BP] GO:0040012 regulation of locomotion APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK, TERT 5.92481
[BP] GO:0051270 regulation of cellular component movement APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK, TERT 5.90891
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, FABP4, HMGCR, HSD17B2, IGF1R, INSR, KIT, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR 5.63593
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC, TEK 5.58019
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, RORC, SRC, TYR 5.48261
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, FUT7, HMGCR, KIT, MET, PPARA 5.46089
[BP] GO:0009628 response to abiotic stimulus AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, HMGCR, HSPA1A, KIT, MMP2, PPARA, SMAD3, SRC, TEK, TERT, TYR 5.22873
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DYRK1A, EGFR, F10, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK, TOP2A 5.22324
[BP] GO:0010648 negative regulation of cell communication ACHE, BCL2, DUSP3, DYRK1A, EGFR, GPR35, HMGCR, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH 5.20414
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, DYRK1A, EGFR, HMGCR, HSPA1A, IGF1R, MCL1, MET, NUAK1, PTPN1, PTPRS, TERT, XDH 5.19744
[BP] GO:0023057 negative regulation of signaling ACHE, BCL2, DUSP3, DYRK1A, EGFR, GPR35, HMGCR, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH 5.19227
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, EGFR, FLT3, HSD17B2, INSR, KDR, KIT, MCL1, MMP9, PIM1, PPARA, PTPRS, RORC, SMAD3, SRC, TEK, TYR 5.17632
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 5.16591
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CBR1, CDC25B, CYP1A1, EGFR, FABP4, FLT3, FUT7, GLO1, HMGCR, KDR, KIT, MCL1, MET, MMP2, MMP9, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A 5.15868
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT, TOP2A 5.13839
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, INSR, KIT, MET, SRC, TEK, XDH 5.09564
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, EGFR, KIT, PPARA, RORC, SRC, TOP2A 5.09564
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, GLO1, GPR35, HMGCR, HSPA1A, IGF1R, KDR, KIT, MCL1, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 5.06078
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 5.03939
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, INSR, KIT, MET, SRC, TEK 5.03676
[BP] GO:0048585 negative regulation of response to stimulus BCL2, CYP19A1, DUSP3, DYRK1A, EGFR, HMGCR, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH 4.98699
[BP] GO:0042592 homeostatic process AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, EGFR, FABP3, FABP4, FLT3, GPR35, INSR, MCL1, MET, SMAD3, SRC, TERT 4.86574
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 4.80914
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.80914
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, KIT, MMP9, TERT 4.66593
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 4.61455
[BP] GO:0019220 regulation of phosphate metabolic process APP, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.60445
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, DYRK1A, HMGCR, HSPA1A, IGF1R, MCL1, MET, MMP9, PTPN1, SRC, XDH 4.58291
[BP] GO:0051174 regulation of phosphorus metabolic process APP, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.55321
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.5495
[BP] GO:0031399 regulation of protein modification process APP, BCL2, CDC25B, DNMT1, DUSP3, DYRK1A, EGFR, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 4.48549
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 4.45628
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 4.44161
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, HMGCR 4.42034
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, SRC 4.42034
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, TERT 4.41845
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD17B1, HSD17B2, TYR, XDH 4.41129
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, EGFR, FLT3, KIT, MET, PIM1, SRC, TEK, TYR 4.39163
[BP] GO:0009968 negative regulation of signal transduction BCL2, DUSP3, DYRK1A, EGFR, HMGCR, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH 4.34169
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 4.31571
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 4.31571
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC, TEK 4.25493
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, F10, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TOP2A 4.20543
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 4.15236
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, SRC, TERT 4.15236
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 4.11132
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.08181
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, F10, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP2, NUAK1, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TOP2A 4.07238
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, DUSP3, INSR, TERT 4.07238
[BP] GO:0010562 positive regulation of phosphorus metabolic process APP, BCL2, CDC25B, EGFR, FABP3, FLT3, HMGCR, INSR, KDR, KIT, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.07238
[BP] GO:0045937 positive regulation of phosphate metabolic process APP, BCL2, CDC25B, EGFR, FABP3, FLT3, HMGCR, INSR, KDR, KIT, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.07238
[BP] GO:0031325 positive regulation of cellular metabolic process APP, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 4.0282
[BP] GO:0043408 regulation of MAPK cascade APP, DUSP3, EGFR, FLT3, HMGCR, IGF1R, INSR, KDR, KIT, PTPN1, SRC, TEK, XDH 3.9952
[BP] GO:0010604 positive regulation of macromolecule metabolic process APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 3.98829
[BP] GO:0009893 positive regulation of metabolic process APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 3.93686
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MCL1, MMP9, PTPN1, SRC 3.93246
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, BCL2, CA9, CYP1A1, CYP1B1, EGFR, FABP3, HMGCR, KDR, SRC 3.89863
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DUSP3, DYRK1A, EGFR, F10, FLT3, FUT7, GLO1, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 3.89383
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, HMGCR, KDR, SRC 3.89375
[BP] GO:0051247 positive regulation of protein metabolic process APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, FLT3, HMGCR, HSPA1A, INSR, KDR, KIT, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.8647
[BP] GO:0043410 positive regulation of MAPK cascade APP, EGFR, FLT3, HMGCR, INSR, KDR, KIT, PTPN1, SRC, TEK, XDH 3.85181
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.84551
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CYP1B1, DNMT1, EGFR, IGF1R, INSR, MMP2, MMP9, RORC, SRC 3.807
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, SRC, TERT, TOP2A 3.80353
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HMGCR, TYR 3.80353
[BP] GO:0065009 regulation of molecular function ABCB1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KIT, MET, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.79717
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.79717
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, BCL2, DNMT1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, SMAD3, SRC, TEK 3.78841
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, KIT, MMP9, TERT 3.78277
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.7793
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.73432
[BP] GO:0043412 macromolecule modification ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, F10, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TOP2A 3.71253
[BP] GO:0042325 regulation of phosphorylation APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, KIT, MMP9, PPARA, PTPN1, SRC, TEK, XDH 3.70928
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 3.6913
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.67016
[BP] GO:0051049 regulation of transport ABCB1, ACHE, APP, AXL, BCL2, CA2, CA7, CYP19A1, EGFR, GPR35, HMGCR, HSPA1A, INSR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TERT 3.66407
[BP] GO:0009987 cellular process ABCB1, ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DUSP3, DYRK1A, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MCL1, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 3.65938
[BP] GO:0031401 positive regulation of protein modification process APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, FLT3, HMGCR, INSR, KDR, KIT, MMP9, PTPN1, SRC, TEK, XDH 3.64541
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 3.6293
[BP] GO:0032270 positive regulation of cellular protein metabolic process APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, FLT3, HMGCR, HSPA1A, INSR, KDR, KIT, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.6213
[BP] GO:0043405 regulation of MAP kinase activity DUSP3, EGFR, FLT3, HMGCR, IGF1R, INSR, KIT, PTPN1, SRC 3.62021
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CYP1B1, EGFR, HMGCR, HSPA1A, KDR, KIT, MET, MMP12, MMP9, PIM1, SMAD3, SRC, TEK, TERT 3.61646
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SMAD3, SRC, TERT 3.59615
[BP] GO:0001932 regulation of protein phosphorylation APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, KIT, MMP9, PTPN1, SRC, TEK, XDH 3.5925
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.56464
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, IGF1R, INSR, PPARA, SRC, TEK 3.54391
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK, TERT 3.54307
[BP] GO:0001934 positive regulation of protein phosphorylation APP, BCL2, CDC25B, EGFR, FLT3, HMGCR, INSR, KDR, KIT, MMP9, PTPN1, SRC, TEK, XDH 3.53289
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, DNMT1, EGFR, FLT3, IGF1R, INSR, KIT, MMP2, SMAD3, SRC 3.53289
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, EGFR, FLT3, RORC, SRC 3.53289
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, KIT, MMP9, RORC 3.52751
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 3.46885
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK, TERT 3.46339
[BP] GO:0050790 regulation of catalytic activity APP, AURKB, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KIT, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.45855
[BP] GO:0019216 regulation of lipid metabolic process CYP1A1, FABP3, FLT3, HMGCR, KIT, PPARA, RORC, SRC, TEK 3.4295
[BP] GO:0006464 cellular protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, F10, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TOP2A 3.42454
[BP] GO:0036211 protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, F10, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TOP2A 3.42454
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR 3.41538
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, SRC, TEK 3.40877
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade APP, DUSP3, EGFR, HMGCR, KDR, PTPN1, SRC, TEK 3.3957
[BP] GO:0009892 negative regulation of metabolic process APEX1, APP, AURKB, BCL2, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, FABP4, HMGCR, HSPA1A, IGF1R, KDR, MCL1, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, XDH 3.3706
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HMGCR, HSD17B1, HSD17B2 3.35455
[BP] GO:0043549 regulation of kinase activity APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, KIT, PTPN1, SRC, TEK 3.34707
[BP] GO:0042327 positive regulation of phosphorylation APP, BCL2, CDC25B, EGFR, FLT3, HMGCR, INSR, KDR, KIT, MMP9, PTPN1, SRC, TEK, XDH 3.34581
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.34541
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.34541
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC, TEK 3.34281
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC, TEK 3.3348
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, TERT 3.33175
[BP] GO:0006950 response to stress ACHE, AKR1B1, APEX1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, KIT, MCL1, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A 3.30515
[BP] GO:2001240 None BCL2, HSPA1A, MCL1, TERT 3.29181
[BP] GO:1901099 None BCL2, HSPA1A, MCL1, TERT 3.29181
[BP] GO:0051338 regulation of transferase activity APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, KIT, PTPN1, SRC, TEK 3.23705
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK, TERT 3.23463
[BP] GO:0044092 negative regulation of molecular function APP, AURKB, CSNK2A1, CYP1B1, DUSP3, FABP4, GPR35, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.23156
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.23064
[BP] GO:0010638 positive regulation of organelle organization AURKB, BCL2, DNMT1, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.22846
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, EGFR, IGF1R, INSR, MMP2, SRC 3.18248
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, HSPA1A, MCL1, MMP9, PTPN1, SRC, TERT 3.17157
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, HMGCR, HSD17B1, HSD17B2 3.15245
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH 3.12409
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH 3.11286
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, HSD17B2, INSR, KIT, MMP2, MMP9, SRC, TOP2A 3.11284
[BP] GO:0065007 biological regulation ABCB1, ACHE, AKR1B1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DUSP3, DYRK1A, EGFR, F10, FABP3, FABP4, FLT3, GLO1, GPR35, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MCL1, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 3.10676
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, APP, AURKB, BCL2, CSNK2A1, DNMT1, DUSP3, DYRK1A, FABP4, HMGCR, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, XDH 3.05516
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 3.05436
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, HSPA1A 3.02885
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.02088
[BP] GO:0031347 regulation of defense response CYP19A1, EGFR, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK 2.99225
[BP] GO:0045859 regulation of protein kinase activity APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, KIT, PTPN1, SRC 2.98308
[BP] GO:0032268 regulation of cellular protein metabolic process APP, BCL2, CDC25B, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.97307
[BP] GO:0044093 positive regulation of molecular function ABCB1, APP, AURKB, BCL2, CDC25B, EGFR, FLT3, HSPA1A, INSR, KIT, MET, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, XDH 2.95462
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, EGFR, FABP3, HSD17B2, KDR, MMP2, SRC 2.95462
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, EGFR, IGF1R, INSR, MMP2, SRC 2.93765
[BP] GO:0043551 regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 2.92603
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.92603
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, EGFR, FABP3, FABP4, GPR35, INSR, MET, SMAD3 2.91947
[BP] GO:0051128 regulation of cellular component organization APP, AURKB, AXL, BCL2, CSNK2A1, DNMT1, EGFR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, PTPN1, PTPRS, SMAD3, SRC, TEK, TOP2A 2.8925
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MCL1, MMP9, PTPN1, SRC 2.87036
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, KIT, MMP9, RORC, SMAD3, SRC 2.85417
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, APP, AXL, BCL2, CA2, CYP19A1, EGFR, INSR, MMP12, SMAD3, SRC, TERT 2.83685
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.83294
[BP] GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand BCL2, HSPA1A, MCL1, TERT 2.82261
[BP] GO:0007166 cell surface receptor signaling pathway APP, AXL, BCL2, CA1, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MCL1, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 2.81951
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 2.79089
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, KDR, KIT, TEK 2.79089
[BP] GO:0019222 regulation of metabolic process ACHE, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, FLT3, GLO1, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MCL1, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 2.78724
[BP] GO:2000811 negative regulation of anoikis BCL2, MCL1, SRC 2.77154
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, TEK, TYR 2.7565
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, SMAD3, XDH 2.72897
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.7227
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.7227
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.7227
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.7227
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.70365
[BP] GO:0031323 regulation of cellular metabolic process ACHE, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, FLT3, GLO1, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MCL1, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 2.69141
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, SMAD3, SRC, TEK 2.68972
[BP] GO:2001237 negative regulation of extrinsic apoptotic signaling pathway BCL2, HSPA1A, MCL1, SRC, TERT 2.68972
[BP] GO:0010564 regulation of cell cycle process APEX1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, EGFR, HSPA1A, INSR, TERT 2.68326
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 2.67268
[BP] GO:0043550 regulation of lipid kinase activity FLT3, KIT, SRC, TEK 2.64786
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, HSD17B2, INSR, KIT, SRC 2.62385
[BP] GO:0009611 response to wounding ACHE, BCL2, CYP1A1, EGFR, PPARA, SMAD3 2.61605
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.59362
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1 2.59362
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.59362
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.58729
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, HSD17B2, INSR, KIT, SRC 2.58723
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.58723
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.58502
[BP] GO:0033554 cellular response to stress AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, HSPA1A, MCL1, MMP9, NUAK1, PTPN1, SRC, TERT, TOP2A 2.57765
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, DNMT1, EGFR, IGF1R, INSR, KDR, KIT, MCL1, MET, NUAK1, PTPN1, SRC, TEK 2.57571
[BP] GO:0090068 positive regulation of cell cycle process APEX1, APP, AURKB, CDC25B, CYP1A1, INSR, TERT 2.55269
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, APP, AURKB, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, FABP4, HMGCR, HSPA1A, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, XDH 2.54322
[BP] GO:0030098 lymphocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, RORC 2.52167
[BP] GO:2001233 regulation of apoptotic signaling pathway BCL2, HSPA1A, MCL1, MMP9, PTPN1, SMAD3, SRC, TERT 2.52167
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.52167
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, RORC 2.5179
[BP] GO:0051172 None APEX1, APP, AURKB, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, FABP4, HMGCR, HSPA1A, IGF1R, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, XDH 2.51486
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, MET, SMAD3, SRC 2.48679
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, EGFR, KDR, SRC 2.48679
[BP] GO:0071900 regulation of protein serine/threonine kinase activity DUSP3, EGFR, FLT3, HMGCR, IGF1R, INSR, KIT, PTPN1, SRC 2.48301
[BP] GO:0080090 regulation of primary metabolic process APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, FLT3, GLO1, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 2.48199
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4 2.47464
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.47464
[BP] GO:0016311 None ALPL, APEX1, BCL2, CDC25B, DUSP3, PTPN1, PTPRS 2.47464
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, EGFR, HMGCR, KIT, TYR 2.46642
[BP] GO:0009894 regulation of catabolic process APEX1, BCL2, CSNK2A1, EGFR, HSPA1A, INSR, KDR, MCL1, MET, PPARA, PTPN1, SMAD3 2.4636
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, FABP4, FLT3, GLO1, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 2.4636
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.43265
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade APP, EGFR, HMGCR, KDR, SRC, TEK 2.43265
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.42968
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.425
[BP] GO:0032101 regulation of response to external stimulus CYP19A1, EGFR, FABP4, HMGCR, KDR, MET, MMP12, PPARA, PTPRS, SMAD3, TEK 2.40613
[BP] GO:0043085 positive regulation of catalytic activity APP, AURKB, BCL2, CDC25B, EGFR, FLT3, HSPA1A, INSR, KIT, PTPN1, SMAD3, SRC, TEK, TERT, XDH 2.38446
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA 2.38371
[BP] GO:2000209 regulation of anoikis BCL2, MCL1, SRC 2.37778
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.37778
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.3671
[BP] GO:0051248 None APP, CSNK2A1, DNMT1, DUSP3, EGFR, FABP4, HMGCR, HSPA1A, IGF1R, MMP9, PTPN1, SMAD3, SRC, XDH 2.3671
[BP] GO:0051094 positive regulation of developmental process APP, AXL, BCL2, CA2, CYP1B1, HMGCR, INSR, KDR, KIT, PIM1, SMAD3, SRC, TEK, TERT 2.35731
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.35544
[BP] GO:0051246 regulation of protein metabolic process APP, BCL2, CDC25B, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.35544
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, APP, BACE1, CA2, CA7, EGFR, KIT 2.35544
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, APP, BACE1, CA2, CA7, EGFR, KIT 2.35544
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.35086
[BP] GO:0051894 None KDR, SMAD3, TEK 2.33948
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.33948
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, IGF1R, INSR, SRC 2.33698
[BP] GO:0030154 cell differentiation ALPL, AXL, BCL2, CBR1, CYP1A1, FABP4, FLT3, FUT7, GLO1, HMGCR, KDR, KIT, MMP2, MMP9, RORC, SMAD3, TOP2A 2.33186
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling FLT3, KDR, KIT, TEK 2.3318
[BP] GO:0051171 regulation of nitrogen compound metabolic process APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, FLT3, GLO1, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 2.3318
[BP] GO:0014910 regulation of smooth muscle cell migration APEX1, BCL2, SRC, TERT 2.31173
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, SMAD3, SRC, TERT 2.31173
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.30837
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.30083
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, DNMT1, EGFR, IGF1R, INSR, SRC 2.29408
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.25319
[BP] GO:1903393 None KDR, SMAD3, TEK 2.25319
[BP] GO:1901992 positive regulation of mitotic cell cycle phase transition APEX1, APP, CYP1A1, TERT 2.24887
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD17B1, HSD17B2 2.23956
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, SRC 2.23638
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3 2.23399
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, EGFR, HMGCR, SRC, TYR 2.2241
[BP] GO:0046649 lymphocyte activation AXL, BCL2, FLT3, FUT7, KIT, RORC, SMAD3 2.22096
[BP] GO:0016477 cell migration AXL, CYP1B1, EGFR, FUT7, KDR, KIT, MMP1, MMP12, MMP9, SRC, TEK 2.21571
[BP] GO:0050793 regulation of developmental process APP, AXL, BCL2, CA2, CYP1B1, EGFR, HMGCR, INSR, KDR, KIT, NUAK1, PIM1, PPARA, PTPRS, RORC, SMAD3, SRC, TEK, TERT, XDH 2.20987
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.18749
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.1787
[BP] GO:1901987 None APEX1, APP, AURKB, BCL2, CDC25B, CYP1A1, EGFR, TERT 2.16988
[BP] GO:0007155 cell adhesion ACHE, APP, AXL, BCL2, CYP1B1, EGFR, KIT, NUAK1, PTPRS, SRC, TEK 2.15167
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.13249
[BP] GO:0050730 None APP, EGFR, FLT3, KIT, PTPN1, SRC 2.13226
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CYP1A1, HMGCR, TERT 2.13226
[BP] GO:0022610 biological adhesion ACHE, APP, AXL, BCL2, CYP1B1, EGFR, KIT, NUAK1, PTPRS, SRC, TEK 2.13075
[BP] GO:0051239 regulation of multicellular organismal process APP, AXL, BCL2, CA2, CYP1B1, EGFR, GPR35, HMGCR, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, PIM1, PTPRS, SMAD3, SRC, TEK, TERT, XDH 2.11851
[BP] GO:0002244 None BCL2, FLT3, KIT, TOP2A 2.11742
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.11742
[BP] GO:2000026 regulation of multicellular organismal development APP, AXL, BCL2, CA2, CYP1B1, EGFR, HMGCR, INSR, KDR, KIT, PIM1, PTPRS, SMAD3, SRC, TEK, TERT, XDH 2.10119
[BP] GO:1901661 None AKR1B1, AKR1B10, HMGCR 2.09848
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.09848
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.09204
[BP] GO:0040011 locomotion AXL, CYP1B1, EGFR, FUT7, KDR, KIT, MET, MMP1, MMP12, MMP9, SRC, TEK 2.0917
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, DNMT1, EGFR, HSPA1A, IGF1R, INSR, MET, MMP12, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A 2.08335
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.08335
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.08335
[BP] GO:1901890 None KDR, SMAD3, TEK 2.06554
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.06554
[BP] GO:2000352 None KDR, TEK, TERT 2.06554
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.0469
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.03795
[BP] GO:1990535 None APP, INSR 2.03795
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.03795
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP3A4 2.03795
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, TYR 2.03514
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.03514
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, SMAD3, SRC 2.02269
[BP] GO:0051704 multi-organism process APP, AXL, BCL2, CYP1A1, DYRK1A, EGFR, HSPA1A, INSR, KDR, MET, MMP1, MMP12, SMAD3, SRC 2.02269
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, SRC 2.02269
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 2.02269
[BP] GO:2001236 regulation of extrinsic apoptotic signaling pathway BCL2, HSPA1A, MCL1, SRC, TERT 2.02269
[BP] GO:0006775 fat-soluble vitamin metabolic process CBR1, CYP1A1, CYP3A4 2.0043
[BP] GO:1902893 None PPARA, SMAD3, TERT 2.0043
[BP] GO:0010907 None INSR, PPARA, SRC 2.0043
[BP] GO:0106027 None APP, IGF1R, INSR 2.0043
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, MET, SMAD3, SRC 2.00277
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, EGFR, HMGCR, KDR, SRC 2.00277
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, AKR1B1, AKR1B10, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MCL1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, RORC, SMAD3, SRC, TERT, TOP2A, TYR, XDH 3.56806
[CC] GO:0043226 organelle ABCB1, ACHE, AKR1B1, AKR1B10, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MCL1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, RORC, SMAD3, SRC, TERT, TOP2A, TYR, XDH 2.68972
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, EGFR, F10, FLT3, GLO1, GPR35, IGF1R, INSR, KDR, KIT, MET, MMP2, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT 2.55259
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, ALOX5, APEX1, APP, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, KIT, MCL1, MMP2, MMP9, PIM1, PTPN1, PTPRS, SMAD3, SRC, TERT, TOP2A, TYR, XDH 2.43701
[CC] GO:0045121 membrane raft APP, BACE1, EGFR, INSR, KDR, SRC, TEK 2.40571
[CC] GO:0098857 membrane microdomain APP, BACE1, EGFR, INSR, KDR, SRC, TEK 2.38883
[CC] GO:0009986 cell surface ABCB1, ACHE, APP, AXL, BACE1, CA4, EGFR, MET, TEK 2.29733
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, F10, FLT3, HMGCR, HSD17B2, PTPN1 2.28488
[CC] GO:0016020 membrane ABCB1, ACHE, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, F10, FLT3, FUT7, GLO1, GPR35, HMGCR, HSD17B2, IGF1R, INSR, KDR, KIT, MCL1, MET, MMP2, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TYR 2.18729
[CC] GO:0043231 intracellular membrane-bounded organelle ACHE, AKR1B1, AKR1B10, APEX1, APP, AURKB, BACE1, BCL2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DUSP3, DYRK1A, EGFR, FABP4, FLT3, FUT7, GLO1, HMGCR, HSPA1A, IGF1R, KDR, KIT, MCL1, MMP12, MMP2, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A, TYR, XDH 2.1787
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.03795
[CC] GO:0098589 membrane region APP, BACE1, EGFR, INSR, KDR, SRC, TEK 2.0043
[MF] GO:0003824 catalytic activity ABCB1, ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DUSP3, DYRK1A, EGFR, F10, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, PTPRS, SRC, TEK, TERT, TOP2A, TYR, XDH 15.3515
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DYRK1A, EGFR, F10, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 12.732
[MF] GO:0046914 transition metal ion binding ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, TYR, XDH 11.8298
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.0966
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 9.06914
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 8.33401
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 7.82131
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PPARA, SRC, TEK, TOP2A 7.27156
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.14717
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.62123
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 5.99658
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, F10, GLO1, KIT, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, TERT, TOP2A, TYR, XDH 5.94924
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, DNMT1, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, SMAD3 5.64203
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, F10, GLO1, KIT, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, TERT, TOP2A, TYR, XDH 5.59873
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 5.52937
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.49163
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD17B1, HSD17B2, TYR, XDH 5.4294
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR, KIT 5.42415
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.23021
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 5.07193
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, F10, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, PTPRS, SRC, TEK 4.86551
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 4.61455
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TERT 4.48849
[MF] GO:0043168 anion binding ABCB1, APP, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, F10, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PTPRS, SRC, TEK, TOP2A, XDH 4.34169
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HMGCR, HSD17B1, HSD17B2, XDH 4.20543
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.16386
[MF] GO:0036094 small molecule binding ABCB1, AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP2A, XDH 4.08181
[MF] GO:0000166 nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, EGFR, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP2A, XDH 3.98829
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, EGFR, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP2A, XDH 3.9878
[MF] GO:0044877 macromolecular complex binding ACHE, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 3.95097
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.93246
[MF] GO:0042802 identical protein binding ACHE, APP, BCL2, CSNK2A1, DYRK1A, EGFR, FLT3, HMGCR, IGF1R, KDR, KIT, MCL1, MET, MMP9, SMAD3, TERT, TOP2A, TYR, XDH 3.84493
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 3.81445
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP2A 3.8073
[MF] GO:0019902 phosphatase binding BCL2, EGFR, HMGCR, MET, PPARA, PTPN1, SMAD3 3.76968
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP2A 3.69531
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP2A 3.66407
[MF] GO:0032403 protein complex binding ACHE, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 3.61646
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD17B1, HSD17B2 3.47221
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.46885
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.33175
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.16538
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 3.03104
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 2.91414
[MF] GO:0097367 carbohydrate derivative binding ABCB1, APP, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PTPRS, SRC, TEK, TOP2A 2.80941
[MF] GO:0035639 purine ribonucleoside triphosphate binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.77103
[MF] GO:0019899 enzyme binding APP, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, CYP3A4, DUSP3, EGFR, HMGCR, HSPA1A, KIT, MET, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A 2.7697
[MF] GO:0032555 purine ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.65832
[MF] GO:0017076 purine nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.62392
[MF] GO:0032553 ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.61775
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD17B1, SRC, XDH 2.59286
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.58729
[MF] GO:0019903 protein phosphatase binding BCL2, EGFR, HMGCR, MET, PTPN1 2.4636
[MF] GO:0005057 signal transducer activity, downstream of receptor EGFR, INSR, KDR, KIT, SMAD3 2.40571
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.38415
[MF] GO:0042803 protein homodimerization activity ACHE, BCL2, FLT3, HMGCR, KIT, MCL1, SMAD3, TERT, TOP2A, TYR, XDH 2.36904
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.35544
[MF] GO:0051425 None APP, INSR 2.35544
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.35544
[MF] GO:1901363 heterocyclic compound binding ABCB1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DYRK1A, EGFR, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 2.3318
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.31173
[MF] GO:0097159 organic cyclic compound binding ABCB1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DYRK1A, EGFR, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 2.27457
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.1787
[MF] GO:0043559 insulin binding IGF1R, INSR 2.1787
[MF] GO:0051434 BH3 domain binding BCL2, MCL1 2.1787
[MF] GO:0051721 None BCL2, HMGCR, PTPN1 2.17438
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.13249
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.06554
[MF] GO:0004064 arylesterase activity CA1, CA2 2.03795


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 9.5611
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.1284
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.3154
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 7.5865
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, ABCB1, BCL2, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B, MCL1 5.9523
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, KIT, BCL2, MMP9, MET, EGFR, IGF1R 4.9889
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KIT, KDR, TEK, MET, EGFR, IGF1R 5.0824
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.296
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KIT, KDR, BCL2, TEK, MET, EGFR, MCL1, IGF1R 4.6566
Metabolic pathways_Homo sapiens_hsa01100 CBR1, DNMT1, AKR1B1, HMGCR, TYR, CYP3A4, CYP19A1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 4.6566
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KIT, KDR, MET, EGFR, IGF1R, HSPA1A 4.6087
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, EGFR, IGF1R 4.332
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KIT, KDR, TEK, MET, EGFR, IGF1R 4.0761
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.332
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, EGFR, HSPA1A 3.8052
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.1473
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, BCL2, TEK, EGFR, IGF1R 3.7481
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, EGFR, IGF1R 3.4046
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET, EGFR 3.2988
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, BCL2, PIM1 2.7097
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2709
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, HMGCR, CYP3A4 3.2435
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.2937
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, BCL2, MMP9 2.191
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.3153
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET, EGFR 2.1195
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.2023
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.1321
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.7335
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.1719
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, CYP3A4 2.1986
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9289
Prostate cancer_Homo sapiens_hsa05215 BCL2, EGFR, IGF1R 1.9045
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.8894
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.7158
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.5098
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.6417
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, HMGCR, IGF1R 1.5926
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, KIT, EGFR 1.4455
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, MCL1 1.3563
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 1.16
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR 1.3612
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.1077
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3213
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0503
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 0.9727
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.299
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 1.041
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.0763
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.1077
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1747
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.1077
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.097
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.2946
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.8545
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5 0.9722
Apoptosis_Homo sapiens_hsa04210 BCL2, MCL1 0.8505
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.0779
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.3213
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8652
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3363
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.9062
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.8505
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9382
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8505
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.8505
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8505
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.299
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8262
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, CYP3A4 1.2662
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5 1.3213
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.8033
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.7744
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.7744
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35 0.2242
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7515
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.6586
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3079
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, TERT 0.5672
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3404
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3307
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.3363
cAMP signaling pathway_Homo sapiens_hsa04024 PPARA 0.314
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3404
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3304
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 INSR 0.3511
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3769
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3849
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4157
Platelet activation_Homo sapiens_hsa04611 SRC 0.4391
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4411
Sphingolipid signaling pathway_Homo sapiens_hsa04071 BCL2 0.4411
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.5058
Axon guidance_Homo sapiens_hsa04360 MET 0.4311
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4391
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4411
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4621
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.479
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4861
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4861
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4901
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4944
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4942
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5258
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5157
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5151
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.5206
Peroxisome_Homo sapiens_hsa04146 XDH 0.5265
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.56
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5615
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5414
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5588
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5473
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5672
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7945
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.583
Shigellosis_Homo sapiens_hsa05131 SRC 0.5849
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6121
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.8119
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.672
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7506
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6351
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6381
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6562
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6586
Malaria_Homo sapiens_hsa05144 MET 0.6668
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9622
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6706
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6966
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.6921
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.7364
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7711
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7307
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8333
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7967
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7711
Base excision repair_Homo sapiens_hsa03410 APEX1 0.776
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.838
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8033
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8333
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8652
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0217
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1728


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)