TCM Prescription: Xiao Yin Capsule



Prescription Description
Prescription IDTCMF951
Pinyin NameXiao Yin Jiao Nang 
Chinese Name消银胶囊
English NameXiao Yin Capsule
Function Description白疕血热, 血虚风燥证, 症见皮疹点滴状, 基底鲜红色, 表面覆有银白色鳞屑, 或鳞屑较厚, 瘙痒
IndicationsBlood heat pattern, Blood deficiency pattern
Disease ICD-11 Category SF02 [Blood heat pattern (TM1), 血热证 (TM1) ];
SF00 [Blood deficiency pattern (TM1), 血虚证 (TM1) ];
Human Tissues Associated with IndicationSkin, Blood
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH258 Paeonia obovata 赤芍 TCMH258 GBVX7902-15
TCMH1215 Sophora flavescens 苦参 TCMH1215 ITSAM449-14
TCMH2343 Scrophularia ningpoensis 玄参 TCMH2343 ITSAO4295-14
TCMH235 Periostracum cicadae 蝉蜕 TCMH235
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH1513 Paeonia moutan 牡丹皮 TCMH1513
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH1127 Lonicera japonica 金银花 TCMH1127 ITSAI3881-14
TCMH1562 Arctium lappa 牛蒡子 TCMH1562 ITSAI1776-14
TCMH112 Dictamnus albus 白藓皮 TCMH112 GBVK982-11
TCMH381 Isatis indigotica 大青叶 TCMH381 KJ765825
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT575 PLA2G2A Phospholipase A2 group IIA Hydrolase P14555
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT904 PGR Progesterone receptor Nuclear receptor P06401
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1208 Escherichia coli K12
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1241 Human rhinovirus 14
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1333 Human rhinovirus 1A
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, FABP3, FUT7, HMGCR, HSPA1A, IDO1, MIF, PIM1, PPARA, PTGS2, TYR, XDH 14.467
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DHFR 12.5361
[BP] GO:0010033 response to organic substance AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP2, NR3C1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 12.5361
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, APP, AR, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, ESRRA, FABP3, GSK3B, HMGCR, HSD17B2, IDO1, IGF1R, INSR, MMP2, MMP9, NR3C1, PPARA, PTGS2, RORC, SRC, TEK, TYR 12.5361
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GSK3B, HMGCR, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR, XDH 12.3641
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ESR1, FABP3, FABP4, FUT7, HMGCR, HSD17B1, HSD17B2, MET, MIF, PPARA, PTGS2 12.3415
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.7954
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GSK3B, HMGCR, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP2, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR, XDH 11.6522
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AR, CSNK2A1, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FLT3, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PGR, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 10.8885
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, GSK3B, HCAR2, HMGCR, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PTGS2, SMAD3, SRC, TEK, XDH 10.8595
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, GSK3B, HCAR2, HMGCR, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PTGS2, SMAD3, SRC, TEK, XDH 10.8531
[BP] GO:0042221 response to chemical AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 10.8531
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGS2 10.0403
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, GSK3B, HMGCR, HSD17B1, HSD17B2, IDO1, PTGS2, TYR, XDH 9.85916
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGS2 9.73655
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 9.61841
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FLT3, GPR35, GSK3B, HCAR2, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, XDH 9.54129
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2 9.44145
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, HMGCR, HSD17B1, HSD17B2 9.44145
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, GSK3B, HCAR2, HMGCR, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, MIF, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 9.22926
[BP] GO:0009719 response to endogenous stimulus AKR1B1, AKR1C3, APP, AR, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GSK3B, IGF1R, INSR, MMP2, NR3C1, PPARA, PTGS2, SMAD3, SRC, TEK 9.15877
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GPR35, GSK3B, HCAR2, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, XDH 8.96911
[BP] GO:0033993 response to lipid AKR1C3, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD17B2, IDO1, NR3C1, PTGS2, RORC, SRC, TYR 8.92081
[BP] GO:0014070 response to organic cyclic compound AKR1C3, APP, AR, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, ESRRA, FLT3, NR3C1, PTGS2, RORC, SRC, TEK, TYR 8.87828
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 8.84353
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AKR1C3, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GSK3B, HCAR2, HMGCR, HSPA1A, IDO1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 8.68833
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, CSNK2A1, CYP1B1, EGFR, F10, FLT3, GPR35, GSK3B, HMGCR, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PTGS2, SMAD3, SRC, TEK, XDH 8.68053
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AKR1C3, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GSK3B, HCAR2, HMGCR, HSPA1A, IDO1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 8.65146
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, GSK3B, HMGCR, HSPA1A, IDO1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK 8.62055
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, FABP3, FABP4, FUT7, HMGCR, MET, MIF, PPARA, PTGS2 8.52568
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, GSK3B, HMGCR, HSPA1A, IDO1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK 8.48115
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, NUAK1, PTGS2, SRC, TEK, XDH 8.48115
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, CYP1B1, EGFR, F10, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, MET, MIF, PTGS2, SRC, TEK, XDH 8.44988
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGS2 8.12671
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, CSNK2A1, CYP1B1, EGFR, ESRRA, F10, FABP4, FLT3, GPR35, GSK3B, HMGCR, HSPA1A, IDO1, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, PTGS2, SMAD3, SRC, TEK, XDH 8.12615
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AKR1C3, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GSK3B, HCAR2, HMGCR, HSPA1A, IDO1, IGF1R, KDR, MIF, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 8.02491
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, FLT3, GPR35, GSK3B, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PTGS2, SMAD3, SRC, TEK, XDH 7.87592
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 7.81676
[BP] GO:0009725 response to hormone AKR1B1, AKR1C3, AR, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, INSR, NR3C1, PPARA, PTGS2, SRC, TEK 7.81175
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, GSK3B, HMGCR, HSPA1A, IDO1, IGF1R, KDR, MIF, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK 7.77952
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, FLT3, GPR35, GSK3B, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PTGS2, SMAD3, SRC, TEK, XDH 7.74637
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PIM1, PPARA, RORC, SRC 7.63532
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PPARA, PTGS2 7.49273
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PTGS2, RORC, SMAD3, SRC 7.43268
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2 7.28493
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APP, AR, AURKB, AXL, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GSK3B, HMGCR, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR, XDH 7.24437
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, ALOX15, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PTGS2, SRC 7.20537
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, PIM1, SRC, TEK 7.16782
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, CA2, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GSK3B, HMGCR, HSD17B2, INSR, KDR, MET, MIF, MMP2, MMP9, PGR, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 7.11508
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 7.02077
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 7.00934
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, FABP4, FLT3, GPR35, GSK3B, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, NUAK1, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 6.88221
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, DHFR, DUSP3, EGFR, ESR1, FABP4, GSK3B, HMGCR, HSPA1A, IDO1, IGF1R, MET, MIF, MMP12, MMP2, NUAK1, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 6.86321
[BP] GO:0071310 cellular response to organic substance AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, GSK3B, IGF1R, INSR, KDR, MMP2, NR3C1, PTGS2, RORC, SMAD3, SRC 6.8363
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC 6.8363
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, CA2, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, ESRRA, F10, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NR3C1, NUAK1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 6.76744
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, GSK3B, HSD17B2, INSR, KDR, MMP9, PGR, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 6.63734
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DHFR, EGFR, HSPA1A, IDO1 6.49963
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APP, AR, AURKB, AXL, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GSK3B, HMGCR, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR, XDH 6.49289
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APP, AR, AXL, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, F10, FABP4, HMGCR, HSD17B2, IDO1, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 6.43159
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, GSK3B, HCAR2, HMGCR, HSPA1A, IDO1, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, XDH 6.38094
[BP] GO:0051716 cellular response to stimulus AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, FABP4, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MIF, MMP2, MMP9, NR3C1, NUAK1, PTGS2, RORC, SMAD3, SRC 6.27882
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 6.27882
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, GPR35, GSK3B, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PPARA, PTGS2, SMAD3, SRC, TEK 6.27752
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APP, AR, AXL, CYP1B1, EGFR, ESR1, GSK3B, IGF1R, INSR, MMP2, MMP9, NR3C1, PTGS2, RORC, SRC 6.18496
[BP] GO:0032787 None AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, IDO1, MIF, PPARA, PTGS2 6.12248
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, PTGS2, SMAD3, SRC, TEK 6.03259
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AKR1C3, AR, CSNK2A1, EGFR, ESR1, FLT3, HMGCR, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK 5.99205
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, FLT3, GPR35, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PTGS2, SMAD3, SRC, TEK, XDH 5.8905
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC 5.8905
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, GSK3B, HMGCR, HSPA1A, IDO1, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, XDH 5.86875
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, HCAR2, HMGCR, HSD17B1, HSD17B2 5.81817
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AKR1C3, ALOX15, APP, AR, AURKB, CSNK2A1, DHFR, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, XDH 5.81652
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AKR1C3, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, GSK3B, HSPA1A, IDO1, MMP1, MMP12, MMP2, MMP9, SRC, XDH 5.74407
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, APP, AR, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, NR3C1, PTGS2, RORC, SRC 5.74129
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, PTGS2, SMAD3, SRC, TEK 5.66441
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, AKR1C3, CYP1A1, FABP3, FLT3, HCAR2, HMGCR, PPARA, PTGS2, RORC, SRC, TEK 5.58732
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.54671
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AKR1C3, ALOX15, APP, AR, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, XDH 5.4551
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DHFR, FABP3, IDO1, MIF, PIM1, PPARA, PTGS2, TYR 5.41553
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, AR, CYP19A1, DUSP3, EGFR, ESR1, ESR2, GSK3B, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 5.38895
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, HMGCR 5.29851
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AKR1C3, APP, AR, AURKB, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GSK3B, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PTGS2, RORC, SMAD3, SRC, XDH 5.27058
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AR, AURKB, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, XDH 5.25325
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, PTGS2, SMAD3, SRC, TEK 5.20684
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, PTGS2, SMAD3, SRC, TEK 5.18935
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.15991
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AKR1C3, APP, AR, EGFR, ESR1, FLT3, GSK3B, IGF1R, INSR, MMP2, NR3C1, PTGS2, SMAD3, SRC 5.15204
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.1072
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, DUSP3, EGFR, ESR1, ESR2, GPR35, GSK3B, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, SMAD3, SRC, XDH 5.07826
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, DUSP3, EGFR, ESR1, ESR2, GPR35, GSK3B, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, SMAD3, SRC, XDH 5.05952
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX15, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, HMGCR, TYR 5.03447
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 4.99579
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, AR, EGFR, FLT3, HMGCR, INSR, KDR, MIF, SRC, TEK, XDH 4.96273
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 4.92042
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, AR, DUSP3, EGFR, FLT3, HMGCR, IGF1R, INSR, KDR, MIF, SRC, TEK, XDH 4.90314
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AR, AURKB, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, XDH 4.87932
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DHFR, FABP3, IDO1, MIF, PIM1, PPARA, PTGS2, TYR 4.87311
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 4.87311
[BP] GO:0071248 cellular response to metal ion AKR1C3, ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 4.80754
[BP] GO:0044283 None AKR1B1, AKR1C3, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, DHFR, HMGCR, IDO1, MIF, PTGS2 4.79413
[BP] GO:0006082 organic acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DHFR, FABP3, IDO1, MIF, PIM1, PPARA, PTGS2, TYR 4.77284
[BP] GO:0030335 positive regulation of cell migration APP, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.76845
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, EGFR, F10, INSR, MET, SRC, TEK, XDH 4.75724
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, EGFR, F10, INSR, MET, SRC, TEK 4.73373
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, CYP3A4, HSD17B1, HSD17B2 4.72901
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, EGFR, ESRRB, FABP3, FLT3, HMGCR, INSR, KDR, MIF, MMP9, PTGS2, SMAD3, SRC, TEK, XDH 4.70808
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, EGFR, ESRRB, FABP3, FLT3, HMGCR, INSR, KDR, MIF, MMP9, PTGS2, SMAD3, SRC, TEK, XDH 4.70808
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DHFR, EGFR, FABP3, FLT3, GSK3B, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR 4.62625
[BP] GO:2000147 positive regulation of cell motility APP, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.62625
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD17B1, HSD17B2, MIF, PTGS2 4.62625
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 4.59145
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, CA2, CYP1B1, EGFR, ESRRB, HCAR2, HMGCR, HSPA1A, IDO1, KDR, MET, MIF, MMP12, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK 4.57684
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GPR35, GSK3B, HCAR2, HMGCR, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR, XDH 4.57525
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, EGFR, MMP9, SRC 4.57525
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, AKR1C3, ALOX15, CYP19A1, CYP3A4, DHFR, HMGCR, TYR 4.55905
[BP] GO:0051272 positive regulation of cellular component movement APP, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.51871
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, ESR1, FABP4, HMGCR, IDO1, KDR, MET, MIF, MMP12, PPARA, PTGS2, SMAD3, TEK 4.48649
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1, HMGCR, IDO1 4.44916
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AR, AXL, CA2, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, GPR35, GSK3B, HCAR2, HMGCR, HSPA1A, IDO1, INSR, KDR, MET, MIF, MMP12, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 4.4321
[BP] GO:2000377 regulation of reactive oxygen species metabolic process AKR1C3, CYP1B1, DHFR, EGFR, INSR, PTGS2, SMAD3, XDH 4.4321
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, GSK3B, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, SRC 4.38527
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 4.3791
[BP] GO:0040017 positive regulation of locomotion APP, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.37329
[BP] GO:0010038 response to metal ion AKR1C3, ALOX15, APP, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 4.30633
[BP] GO:0071383 None AKR1C3, AR, EGFR, FLT3, NR3C1, SRC 4.28842
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, DHFR, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 4.27435
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, DHFR, EGFR, PPARA, SMAD3 4.26291
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DHFR, EGFR, FABP3, FLT3, GSK3B, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR 4.25693
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTGS2 4.22958
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, NR3C1, PGR, SRC 4.16645
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CYP19A1, CYP3A4, HMGCR, HSD17B1, HSD17B2 4.16645
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, AR, DUSP3, EGFR, ESRRB, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, MIF, MMP9, PPARA, PTGS2, SRC, TEK, XDH 4.10719
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, APP, AURKB, AXL, CSNK2A1, DHFR, DUSP3, EGFR, FLT3, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTGS2, SRC, TEK, XDH 4.10134
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AR, AURKB, CSNK2A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GPR35, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, MET, MIF, MMP9, NUAK1, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 4.07053
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, AURKB, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, FABP4, FLT3, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, MIF, MMP9, NUAK1, PTGS2, SMAD3, SRC, TEK, XDH 4.05805
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APP, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PTGS2, SRC 4.05192
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 4.02563
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, AR, EGFR, ESRRB, FLT3, HMGCR, INSR, KDR, MIF, MMP9, PTGS2, SRC, TEK, XDH 3.99086
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GSK3B, IGF1R, INSR, PPARA, PTGS2, SRC, TEK 3.99086
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, EGFR, HMGCR, KDR, MIF, SRC, TEK 3.98261
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 3.96959
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.93377
[BP] GO:0010605 negative regulation of macromolecule metabolic process APP, AR, AURKB, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GSK3B, HMGCR, HSPA1A, IGF1R, KDR, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PTGS2, RORC, SMAD3, SRC, XDH 3.92969
[BP] GO:0080135 regulation of cellular response to stress APP, DHFR, DUSP3, EGFR, GSK3B, HMGCR, HSPA1A, IGF1R, MET, MIF, NUAK1, PTGS2, XDH 3.92969
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 3.92969
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DUSP3, EGFR, HMGCR, KDR, MIF, SRC, TEK 3.92969
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, EGFR, HMGCR, HSPA1A, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TYR 3.92969
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, APP, AXL, CA2, CA7, CYP19A1, EGFR, GPR35, GSK3B, HCAR2, HMGCR, HSPA1A, INSR, MIF, MMP12, MMP9, PPARA, PTGS2, SMAD3, SRC 3.92788
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CYP1A1, EGFR, ESR1, FLT3, MET, MIF, PIM1, SRC, TEK, TYR 3.90492
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process AKR1C3, EGFR, INSR, PTGS2, SMAD3, XDH 3.84912
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, EGFR, ESR1, GSK3B, PGR, PPARA, RORC, SRC 3.81323
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, APP, AURKB, AXL, CSNK2A1, DHFR, DUSP3, EGFR, FLT3, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTGS2, SRC, TEK, XDH 3.80255
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, IDO1, MMP12, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 3.77623
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, ESR1, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 3.74848
[BP] GO:0010906 None ESRRB, GSK3B, INSR, PPARA, RORC, SRC 3.69754
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, EGFR, HCAR2, HMGCR, KDR, MIF, PTGS2, SRC 3.69569
[BP] GO:0009968 negative regulation of signal transduction AR, DUSP3, EGFR, ESR1, ESR2, GSK3B, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, SMAD3, SRC, XDH 3.69376
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.69376
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.69376
[BP] GO:0048545 response to steroid hormone AKR1C3, AR, CA2, EGFR, FLT3, NR3C1, PTGS2, SRC 3.68762
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, AR, CSNK2A1, EGFR, ESR1, FLT3, GSK3B, HMGCR, HSPA1A, INSR, KDR, MIF, MMP9, PTGS2, SMAD3, SRC, TEK, XDH 3.68186
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.6729
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, AKR1C3, ALOX15, APP, AR, AURKB, CA9, CSNK2A1, CYP1A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GSK3B, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, XDH 3.66767
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, AKR1C3, ALOX15, APP, AR, AURKB, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GSK3B, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, XDH 3.66629
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, IDO1, PPARA, PTGS2, SMAD3, TEK 3.64177
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.63758
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.59732
[BP] GO:0048869 cellular developmental process ACHE, AKR1C3, APP, AR, AXL, CBR1, CYP1A1, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GSK3B, HMGCR, KDR, MET, MIF, MMP2, MMP9, PGR, PTGS2, RORC, SMAD3, SRC, TEK 3.58712
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, EGFR, FLT3, HMGCR, INSR, KDR, MIF, MMP9, PTGS2, SRC, TEK, XDH 3.58712
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, APP, AR, AXL, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD17B2, IDO1, INSR, MMP2, MMP9, PGR, PTGS2, SRC 3.56683
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PGR, PPARA, PTGS2, RORC, SMAD3, SRC 3.56575
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, AR, AXL, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, PGR, PTGS2, SRC 3.5576
[BP] GO:0031324 negative regulation of cellular metabolic process AKR1C3, APP, AR, AURKB, CSNK2A1, DHFR, DUSP3, ESR1, ESR2, ESRRA, FABP4, GSK3B, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, NR3C1, PPARA, PTGS2, RORC, SMAD3, SRC, XDH 3.5417
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, SRC, TEK 3.53204
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.53204
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.53204
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.53204
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, CA2, CYP19A1, EGFR, GSK3B, HCAR2, INSR, MIF, MMP12, PTGS2, SMAD3, SRC 3.51253
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, KDR, MIF, MMP9, PTGS2, SRC, TEK, XDH 3.48776
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, AR, EGFR, ESR1, FLT3, GSK3B, HMGCR, HSPA1A, INSR, KDR, MIF, MMP9, PTGS2, SMAD3, SRC, TEK, XDH 3.46974
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, DHFR, EGFR, FABP3, HMGCR, KDR, NR3C1, PTGS2, SRC 3.42112
[BP] GO:1902532 negative regulation of intracellular signal transduction DUSP3, ESR1, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP9, PTGS2, SRC, XDH 3.40901
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AKR1C3, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, GSK3B, HSPA1A, IDO1, XDH 3.3884
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.38566
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, AOX1, APP, AR, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DHFR, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GSK3B, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, TYR, XDH 3.38243
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AR, AXL, CA1, CA2, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, GSK3B, HCAR2, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, RORC, SMAD3, SRC, TEK 3.376
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, EGFR, MMP9, SRC 3.37591
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, RORC 3.34796
[BP] GO:1901661 None AKR1B1, AKR1B10, AKR1C3, HMGCR 3.34138
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, NR3C1, SRC 3.31631
[BP] GO:0071276 cellular response to cadmium ion AKR1C3, CYP1A2, EGFR, MMP9 3.28623
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, HMGCR, IGF1R, INSR, MIF, SRC 3.27874
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.24821
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 3.23453
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR, PTGS2 3.21267
[BP] GO:0010675 None ESRRB, GSK3B, INSR, PPARA, RORC, SRC 3.21267
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.18523
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, AR, DUSP3, EGFR, FABP4, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PTGS2, SRC, TEK, XDH 3.18329
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC, TEK 3.17689
[BP] GO:0050793 regulation of developmental process APP, AR, AXL, CA2, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, GSK3B, HMGCR, IDO1, INSR, KDR, MIF, NUAK1, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, XDH 3.1689
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, MET, MMP12, NR3C1, PGR, PPARA, PTGS2, RORC, SMAD3, SRC 3.15552
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, AKR1C3, ALOX15, APP, AR, AURKB, CA9, CSNK2A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, XDH 3.15525
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 3.15359
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 3.14659
[BP] GO:0071396 cellular response to lipid AKR1C3, AR, AXL, EGFR, ESR1, FLT3, NR3C1, RORC, SRC 3.14231
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 3.13692
[BP] GO:0019371 None AKR1C3, CBR1, PTGS2 3.13692
[BP] GO:0048608 reproductive structure development AKR1C3, AR, AXL, CYP19A1, ESR1, HSD17B2, INSR, SRC 3.12833
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK 3.12431
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTGS2 3.09941
[BP] GO:0006066 None AKR1B1, AKR1B10, AKR1C3, APP, CYP1B1, CYP3A4, DHFR, HMGCR 3.06552
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, GSK3B, HSPA1A, IDO1, MIF, MMP2, MMP9, NUAK1, PPARA, PTGS2, SMAD3, SRC, TEK 3.04831
[BP] GO:0051172 None APP, AR, AURKB, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HMGCR, HSPA1A, IGF1R, MIF, MMP12, MMP9, NR3C1, PPARA, PTGS2, RORC, SMAD3, SRC, XDH 3.0429
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, FABP4, IDO1, KDR, MET, MIF, PTGS2, SMAD3 3.03633
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SMAD3, SRC 3.03424
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 3.02957
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, EGFR, GSK3B, HCAR2, HMGCR, MIF, MMP12, PTGS2, SMAD3, SRC 3.02941
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, INSR, MET, SMAD3, SRC 3.02329
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, MIF, PTGS2 3.02232
[BP] GO:0002009 morphogenesis of an epithelium AR, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 3.01387
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KDR, NR3C1, PTGS2, SRC 3.01387
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, APP, AR, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, FABP4, FLT3, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PTGS2, SMAD3, SRC, TEK, XDH 3.01112
[BP] GO:0043393 regulation of protein binding APP, AURKB, GSK3B, MET, MMP9, PPARA, SRC 2.97435
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, EGFR, GSK3B, HCAR2, MIF, MMP12, PTGS2, SMAD3, SRC 2.95767
[BP] GO:0016488 None AKR1B10, AKR1C3 2.95767
[BP] GO:0016487 None AKR1B10, AKR1C3 2.95767
[BP] GO:0016107 None AKR1B10, AKR1C3 2.95767
[BP] GO:0009115 None AOX1, XDH 2.95767
[BP] GO:0006714 None AKR1B10, AKR1C3 2.95767
[BP] GO:1901655 None AKR1B1, AR, EGFR, NR3C1, SRC 2.9527
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AKR1C3, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, GSK3B, HSPA1A, IDO1, SRC, XDH 2.94839
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.94635
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 2.93834
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, IDO1, MIF 2.93566
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, GSK3B, HSPA1A, KDR, MET, MMP1, SMAD3, SRC, TEK 2.93321
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ALOX15, APP, AR, AURKB, CA9, CSNK2A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, XDH 2.93169
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.8783
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.8783
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SMAD3, SRC 2.86075
[BP] GO:0043065 positive regulation of apoptotic process AKR1C3, CYP1B1, GSK3B, HCAR2, HMGCR, IDO1, MMP9, PTGS2, SMAD3, SRC, XDH 2.85948
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.85904
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, EGFR, GSK3B, IGF1R, INSR, MMP2, PTGS2, SRC 2.85161
[BP] GO:0044259 multicellular organismal macromolecule metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.84942
[BP] GO:0043068 positive regulation of programmed cell death AKR1C3, CYP1B1, GSK3B, HCAR2, HMGCR, IDO1, MMP9, PTGS2, SMAD3, SRC, XDH 2.8273
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, GSK3B, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.8157
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.80791
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ALOX15, APP, AR, AURKB, CA9, CSNK2A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, XDH 2.7943
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AR, AURKB, DHFR, EGFR, ESR1, ESR2, FLT3, GSK3B, HSPA1A, INSR, MET, MIF, MMP9, SMAD3, SRC, TEK, XDH 2.7943
[BP] GO:0031334 positive regulation of protein complex assembly ALOX15, ESR1, GSK3B, HSPA1A, MET, MMP1, SRC 2.76257
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, EGFR, GSK3B, HCAR2, MIF, MMP12, PTGS2, SMAD3, SRC 2.74198
[BP] GO:0001954 positive regulation of cell-matrix adhesion GSK3B, KDR, SMAD3, TEK 2.73744
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, F10, FLT3, GSK3B, IGF1R, INSR, KDR, MET, SRC, TEK 2.73645
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.73265
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, DUSP3, EGFR, FABP4, FLT3, GSK3B, HMGCR, IGF1R, INSR, MIF, SRC, TEK 2.72408
[BP] GO:0031960 response to corticosteroid AKR1C3, EGFR, FLT3, NR3C1, PTGS2, SRC 2.70911
[BP] GO:0003018 None ADORA1, EGFR, HMGCR, PTGS2, SRC, TEK 2.70911
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.70373
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.70373
[BP] GO:0010629 None APP, AR, AURKB, DHFR, ESR1, ESR2, ESRRA, FABP4, HSPA1A, KDR, MIF, MMP12, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, XDH 2.69348
[BP] GO:2000107 negative regulation of leukocyte apoptotic process AURKB, AXL, IDO1, MIF 2.67646
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway HSPA1A, MIF, MMP9, PTGS2, SRC 2.66906
[BP] GO:0016101 None AKR1B10, AKR1C3, CYP1A1, CYP1B1, EGFR 2.62676
[BP] GO:0051254 None APP, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, INSR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SMAD3, SRC 2.62215
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, EGFR, GSK3B, IGF1R, INSR, MMP2, PTGS2, SRC 2.61339
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 2.61339
[BP] GO:0050678 None AR, EGFR, KDR, MMP12, PGR, SMAD3, TEK, XDH 2.60276
[BP] GO:0048732 gland development AR, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.58781
[BP] GO:0000904 cell morphogenesis involved in differentiation AR, AXL, MET, SRC, TEK 2.57105
[BP] GO:0010942 positive regulation of cell death AKR1C3, CYP1B1, GSK3B, HCAR2, HMGCR, IDO1, MMP9, PTGS2, SMAD3, SRC, XDH 2.56649
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3 2.56308
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC 2.56308
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.56308
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.56308
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.56308
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.56308
[BP] GO:0060748 None AR, PGR 2.56308
[BP] GO:0046110 None AOX1, XDH 2.56308
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.56308
[BP] GO:0016095 None AKR1B10, AKR1C3 2.56308
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CYP1A1, EGFR, ESR1, PGR, PTGS2, SRC 2.54661
[BP] GO:0030155 regulation of cell adhesion ALOX15, CYP1B1, DUSP3, GSK3B, IDO1, KDR, NUAK1, PPARA, SMAD3, SRC, TEK 2.53861
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, AR, EGFR, FLT3, HMGCR, INSR, KDR, MIF, MMP9, PTGS2, SRC, TEK, XDH 2.53861
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.53639
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.53639
[BP] GO:0001952 regulation of cell-matrix adhesion GSK3B, KDR, SMAD3, SRC, TEK 2.53491
[BP] GO:0051098 regulation of binding APP, AURKB, GSK3B, MET, MMP9, PPARA, SMAD3, SRC 2.51525
[BP] GO:0032870 cellular response to hormone stimulus AKR1C3, AR, EGFR, ESR1, FLT3, INSR, NR3C1, SRC 2.51525
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK 2.51525
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, CA2, CYP19A1, DUSP3, ESR1, ESRRA, HCAR2, HSPA1A, IDO1, MIF, MMP12, MMP2, SMAD3, SRC 2.4932
[BP] GO:0044236 multicellular organism metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.48412
[BP] GO:0010811 positive regulation of cell-substrate adhesion ALOX15, GSK3B, KDR, SMAD3, TEK 2.48412
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.48412
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.48412
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DHFR, EGFR, INSR, PTGS2, SMAD3 2.48412
[BP] GO:0002793 None ACHE, ADORA1, EGFR, HCAR2, MIF, MMP12, SRC 2.48412
[BP] GO:0006109 regulation of carbohydrate metabolic process ESRRB, GSK3B, INSR, PPARA, RORC, SRC 2.48408
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ALOX15, APP, AR, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, FABP4, FLT3, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PTGS2, SMAD3, SRC, TEK, XDH 2.47824
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, MET, SMAD3 2.47264
[BP] GO:1901361 None AOX1, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP3A4, HSPA1A, IDO1, XDH 2.4639
[BP] GO:0046686 response to cadmium ion AKR1C3, CYP1A2, EGFR, MMP9 2.42953
[BP] GO:0048729 tissue morphogenesis AR, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.42815
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.40273
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.40273
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.39692
[BP] GO:0046394 None ALOX15, ALOX5, CYP1A1, DHFR, IDO1, MIF, PTGS2 2.38056
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, CYP1B1, FABP3, HSPA1A, IDO1, PTGS2, SMAD3, XDH 2.37652
[BP] GO:0016053 None ALOX15, ALOX5, CYP1A1, DHFR, IDO1, MIF, PTGS2 2.37328
[BP] GO:0045893 None APP, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SMAD3, SRC 2.37328
[BP] GO:1903508 None APP, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SMAD3, SRC 2.37328
[BP] GO:1902680 None APP, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SMAD3, SRC 2.3708
[BP] GO:0051248 None APP, CSNK2A1, DHFR, DUSP3, EGFR, FABP4, HMGCR, HSPA1A, IGF1R, MIF, MMP9, PTGS2, SMAD3, SRC, XDH 2.3708
[BP] GO:2000026 regulation of multicellular organismal development APP, AR, AXL, CA2, CYP1B1, EGFR, ESR1, ESRRA, GSK3B, HMGCR, IDO1, INSR, KDR, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 2.37033
[BP] GO:0051094 positive regulation of developmental process APP, AR, AXL, CA2, CYP1B1, ESRRB, HMGCR, IDO1, INSR, KDR, PIM1, PTGS2, SMAD3, SRC, TEK 2.36146
[BP] GO:0001503 ossification ALOX15, EGFR, MMP2, MMP9, TEK 2.36018
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.34713
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.34557
[BP] GO:0051186 None AKR1B1, AKR1B10, AKR1C3, CYP1A1, CYP1A2, DHFR, EGFR, HMGCR, PTGS2 2.3424
[BP] GO:0071384 None AKR1C3, EGFR, FLT3, NR3C1 2.33339
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, AOX1, APP, AR, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FLT3, FUT7, GSK3B, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR, XDH 2.33222
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, GSK3B, KDR, SMAD3, SRC, TEK 2.32794
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CYP1A1, DUSP3, EGFR, INSR, MIF, SRC 2.3241
[BP] GO:0006145 None AOX1, XDH 2.3241
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.3241
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.3241
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, MIF, SRC, TEK 2.31944
[BP] GO:0009889 regulation of biosynthetic process ADORA3, AKR1C3, APP, AR, AURKB, CA9, CSNK2A1, CYP1B1, DHFR, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC 2.3152
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.3098
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, HMGCR, MIF, PPARA, SMAD3, TEK 2.28685
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC 2.28685
[BP] GO:0007584 response to nutrient AKR1C3, CYP1A1, EGFR, HMGCR, PTGS2, TYR 2.28364
[BP] GO:0044249 None ACHE, AKR1B1, AKR1C3, ALOX15, ALOX5, AR, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, EGFR, ESR1, ESR2, ESRRA, ESRRB, HMGCR, HSD17B1, HSD17B2, IDO1, MIF, NR3C1, NR3C2, PGR, PPARA, PTGS2, RORC, SMAD3, TYR 2.28364
[BP] GO:0006766 vitamin metabolic process AOX1, CBR1, CYP1A1, CYP3A4, DHFR 2.26833
[BP] GO:0051894 None KDR, SMAD3, TEK 2.26366
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.26366
[BP] GO:2001233 regulation of apoptotic signaling pathway AR, GSK3B, HSPA1A, MIF, MMP9, PTGS2, SMAD3, SRC 2.26366
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, EGFR, HCAR2, MIF, MMP12, SRC 2.25685
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.22756
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, PTGS2 2.22445
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, ESR2, HSPA1A, PIM1 2.21329
[BP] GO:1901360 None ACHE, AKR1B1, AKR1B10, AKR1C3, AOX1, APP, AR, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, ESR1, ESR2, ESRRA, ESRRB, HMGCR, HSD17B1, HSD17B2, HSPA1A, IDO1, NR3C1, NR3C2, PGR, PPARA, PTGS2, RORC, SMAD3, TYR, XDH 2.19361
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, HMGCR, IGF1R, INSR, MIF, SRC 2.18252
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.17181
[BP] GO:0005979 None ESRRB, GSK3B, INSR 2.17181
[BP] GO:1903393 None KDR, SMAD3, TEK 2.17181
[BP] GO:0006693 None AKR1C3, MIF, PTGS2 2.17181
[BP] GO:0006692 None AKR1C3, MIF, PTGS2 2.17181
[BP] GO:0010962 None ESRRB, GSK3B, INSR 2.17181
[BP] GO:0001819 positive regulation of cytokine production CYP1B1, HSPA1A, IDO1, MIF, MMP12, PTGS2, SMAD3, SRC 2.1712
[BP] GO:0032880 regulation of protein localization ACHE, APP, AR, CSNK2A1, EGFR, GSK3B, HCAR2, HMGCR, MIF, MMP12, PTGS2, SMAD3, SRC 2.16939
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, EGFR, FLT3, GPR35, GSK3B, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, SMAD3, SRC, TEK 2.16884
[BP] GO:0045913 None ESRRB, INSR, PPARA, SRC 2.16758
[BP] GO:0003013 None ADORA1, EGFR, HMGCR, PTGS2, SRC, TEK 2.16618
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, MMP9, PTGS2, SMAD3, SRC, XDH 2.15867
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PTGS2, SMAD3, SRC 2.15035
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1 2.14898
[BP] GO:1901653 cellular response to peptide AKR1B1, APP, GSK3B, IGF1R, INSR, SRC 2.14273
[BP] GO:1904646 cellular response to amyloid-beta APP, GSK3B, IGF1R 2.13983
[BP] GO:0010628 positive regulation of gene expression APP, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, GSK3B, HSPA1A, INSR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SMAD3, SRC 2.13428
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, EGFR, PTGS2 2.12661
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, EGFR, PTGS2 2.12661
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, HSPA1A, MIF, MMP9, PTGS2, SRC 2.11474
[BP] GO:0002683 negative regulation of immune system process ADORA1, ALOX15, AXL, CYP19A1, DUSP3, IDO1, MIF, MMP12 2.1113
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.0986
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.09277
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.07622
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, HMGCR, IGF1R, XDH 2.07622
[BP] GO:0031099 regeneration AXL, CSNK2A1, DHFR, EGFR, FLT3 2.07612
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.07528
[BP] GO:0009894 regulation of catabolic process ADORA1, CSNK2A1, EGFR, ESRRB, GSK3B, HCAR2, HSPA1A, INSR, KDR, MET, PPARA, SMAD3 2.07528
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.07528
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, HMGCR, IGF1R, XDH 2.07005
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.06906
[BP] GO:0033554 cellular response to stress AKR1B1, AKR1C3, ALOX15, AXL, CA2, CA9, CYP1B1, DHFR, EGFR, GSK3B, HSPA1A, MIF, MMP9, NUAK1, PTGS2, SRC 2.06575
[BP] GO:0070229 negative regulation of lymphocyte apoptotic process AURKB, IDO1, MIF 2.06575
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, MIF, PTGS2 2.06575
[BP] GO:0051223 None ACHE, APP, EGFR, GSK3B, HCAR2, HMGCR, MIF, MMP12, PTGS2, SMAD3, SRC 2.06227
[BP] GO:0000122 None AR, AURKB, ESR1, ESR2, ESRRA, HSPA1A, MMP12, NR3C1, PPARA, RORC, SMAD3 2.05359
[BP] GO:0031349 positive regulation of defense response EGFR, FABP4, HSPA1A, IDO1, MMP12, MMP2, PTGS2, SRC 2.04403
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, DUSP3, EGFR, FABP4, FLT3, HMGCR, IGF1R, INSR, MIF, SRC 2.03158
[BP] GO:1900180 regulation of protein localization to nucleus APP, EGFR, GSK3B, PTGS2, SMAD3, SRC 2.03123
[BP] GO:0035265 organ growth AR, CYP19A1, ESR1 2.03123
[BP] GO:0070873 None ESRRB, GSK3B, INSR 2.03123
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.03123
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.03123
[BP] GO:1904645 response to amyloid-beta APP, GSK3B, IGF1R 2.03123
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.02528
[BP] GO:0010760 negative regulation of macrophage chemotaxis CYP19A1, MIF 2.01706
[BP] GO:0046113 None AOX1, XDH 2.01706
[BP] GO:1990535 None APP, INSR 2.01706
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.01706
[BP] GO:2001300 lipoxin metabolic process ALOX15, ALOX5 2.01706
[BP] GO:0016115 None AKR1B10, AKR1C3 2.01706
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP3A4 2.01706
[BP] GO:0042060 None ALOX15, EGFR, PPARA, SMAD3 2.01326
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APP, AR, AURKB, CA1, CA2, CA4, CA5A, CA5B, CA7, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GSK3B, HMGCR, HSD17B1, HSD17B2, HSPA1A, IDO1, INSR, KDR, MIF, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGS2, SMAD3, SRC, TYR, XDH 3.49187
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.34682
[CC] GO:0044432 endoplasmic reticulum part APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, F10, FLT3, HMGCR, HSD17B2, NR3C2, PTGS2 2.28364
[CC] GO:0045121 membrane raft APP, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.17181
[CC] GO:0098857 membrane microdomain APP, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.16571
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, AOX1, APP, AR, AURKB, AXL, CA1, CA2, CA4, CA5A, CA5B, CA6, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TYR, XDH 2.11096
[CC] GO:0005789 endoplasmic reticulum membrane CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, HMGCR, HSD17B2, NR3C2, PTGS2 2.06575
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SMAD3, TYR, XDH 23.2756
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.9341
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR, XDH 15.6879
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, DUSP3, EGFR, F10, FLT3, FUT7, GSK3B, HMGCR, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGS2, SRC, TEK, TYR, XDH 12.2474
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, RORC, SMAD3 11.5641
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.8731
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC 10.6489
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, HMGCR, HSD17B1, HSD17B2, IDO1, PTGS2, TYR, XDH 10.6381
[MF] GO:0005496 steroid binding AR, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, NR3C1, NR3C2, PGR, RORC 10.6149
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.66875
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, IDO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGS2, RORC, SMAD3, TYR, XDH 9.44145
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, IDO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGS2, RORC, SMAD3, TYR, XDH 9.123
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 8.53563
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PGR, PPARA, RORC 8.24635
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PGR, PPARA, RORC 8.24635
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH 8.00233
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, IDO1, PTGS2, SRC 7.66664
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.49273
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR 7.46704
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, IDO1, PTGS2, SRC 7.38422
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 7.11508
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, HMGCR, HSD17B1, IDO1, PTGS2, SRC, XDH 6.97527
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PTGS2, TYR 6.94885
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, HSD17B1, NR3C1, NR3C2, PGR, PPARA, RORC 6.83575
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.75096
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 6.29177
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, AOX1, CBR1, HMGCR, HSD17B1, HSD17B2, XDH 6.23319
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC, TEK 5.95006
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, DHFR, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK 5.5814
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 5.42983
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.24736
[MF] GO:0042562 hormone binding ACHE, AR, EGFR, HSD17B1, IGF1R, INSR, NR3C1 5.1869
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC, TEK 5.09713
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC, SMAD3, TEK 5.03049
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC, TEK 4.88374
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.62625
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 4.57525
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, CBR1, HMGCR, HSD17B1, HSD17B2 4.31446
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, AOX1, XDH 4.06034
[MF] GO:0019899 enzyme binding APP, AR, AURKB, CYP1A1, CYP1A2, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRB, GSK3B, HMGCR, HSPA1A, MET, MIF, NR3C1, PGR, PPARA, PTGS2, SMAD3, SRC, TEK 3.91079
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.79346
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GSK3B, HMGCR, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, XDH 3.66629
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, IDO1, PTGS2 3.55197
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, IDO1, PTGS2 3.49744
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 3.46008
[MF] GO:0097159 organic cyclic compound binding ADORA1, AOX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GSK3B, HMGCR, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, XDH 3.44996
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.41772
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, SMAD3, SRC 3.40159
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.38566
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.38566
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, CSNK2A1, EGFR, ESR1, ESR2, FLT3, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PGR, PTGS2, SMAD3, TYR, XDH 3.14659
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, SMAD3, SRC 3.12431
[MF] GO:0045550 None AKR1B10, AKR1C3 2.95767
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.95767
[MF] GO:0008389 None CYP2A13, CYP2A6 2.95767
[MF] GO:0043168 anion binding ALOX15, AOX1, APP, AURKB, AXL, CSNK2A1, DHFR, EGFR, F10, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, XDH 2.93827
[MF] GO:0008013 beta-catenin binding AR, CSNK2A1, ESR1, GSK3B, SMAD3 2.93566
[MF] GO:0000978 None AR, ESR1, ESR2, ESRRA, NR3C1, PGR, PPARA, RORC, SMAD3 2.85886
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CSNK2A1, DHFR, EGFR, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, XDH 2.76783
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.73744
[MF] GO:0000987 None AR, ESR1, ESR2, ESRRA, NR3C1, PGR, PPARA, RORC, SMAD3 2.72745
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.56308
[MF] GO:0047718 None AKR1B10, AKR1C3 2.56308
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.56308
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSPA1A, KDR, NR3C1 2.49982
[MF] GO:0001085 RNA polymerase II transcription factor binding AR, ESR1, GSK3B, PPARA, SMAD3 2.33222
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.3241
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.3241
[MF] GO:0051425 None APP, INSR 2.3241
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.3241
[MF] GO:0000166 nucleotide binding AOX1, AURKB, AXL, CSNK2A1, DHFR, EGFR, FLT3, GSK3B, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, XDH 2.31791
[MF] GO:1901265 nucleoside phosphate binding AOX1, AURKB, AXL, CSNK2A1, DHFR, EGFR, FLT3, GSK3B, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, XDH 2.31612
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.27432
[MF] GO:0004033 None AKR1B1, AKR1B10, AKR1C3 2.17181
[MF] GO:0001012 None AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PPARA, RORC, SMAD3 2.16226
[MF] GO:0000977 None AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PPARA, RORC, SMAD3 2.16226
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.15035
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.14898
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.14898
[MF] GO:0043559 insulin binding IGF1R, INSR 2.14898
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C3, HSD17B1, HSD17B2 2.13983
[MF] GO:0016229 steroid dehydrogenase activity AKR1C3, HSD17B1, HSD17B2 2.06575
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.06575
[MF] GO:0004064 arylesterase activity CA1, CA2 2.01706
[MF] GO:0043546 None AOX1, XDH 2.01706
[MF] GO:0047035 testosterone dehydrogenase (NAD+) activity AKR1C3, HSD17B2 2.01706


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 18.1314
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, AKR1C3, CYP1B1, PTGS2, CYP19A1, IGF1R 12.7513
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, AKR1C3, CYP1B1, CYP3A4, CYP19A1 8.7005
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1C3, AKR1B1, HMGCR, PTGS2, TYR, CYP3A4, CYP19A1, DHFR, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, XDH, IDO1 7.15
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 7.5867
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.6426
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 6.6426
Pathways in cancer_Homo sapiens_hsa05200 AR, GSK3B, SMAD3, FLT3, MMP1, MMP2, PTGS2, MMP9, MET, EGFR, IGF1R 5.4227
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, EGFR, ESR2, HSPA1A 5.815
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 5.0113
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 5.2623
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.2485
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, AKR1C3, PTGS2 4.4432
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 3.9076
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 4.3709
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.3638
Focal adhesion_Homo sapiens_hsa04510 GSK3B, SRC, KDR, MET, EGFR, IGF1R 3.0834
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1, PTGS2 3.3345
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 2.9087
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, INSR, KDR, TEK, MET, EGFR, IGF1R 2.7908
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, SRC, ESR1, ESR2 2.9935
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1, CYP3A4 3.0454
Prostate cancer_Homo sapiens_hsa05215 AR, GSK3B, EGFR, IGF1R 2.7279
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0454
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR 2.401
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.5028
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15, PTGS2 2.401
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.1604
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, SMAD3, ESRRB, IGF1R 2.0818
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.1604
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.1133
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.081
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.7908
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.0437
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1 1.6849
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, SRC, EGFR 1.8156
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.0744
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.7815
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.4621
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, CYP3A4 2.0437
Insulin resistance_Homo sapiens_hsa04931 GSK3B, INSR, PPARA 1.6048
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF, TYR 2.7673
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, SRC, ESR1 1.536
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.4958
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 2.9602
Measles_Homo sapiens_hsa05162 GSK3B, CSNK2A1, HSPA1A 1.4034
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, HMGCR, IGF1R 1.4947
Hepatitis C_Homo sapiens_hsa05160 GSK3B, PPARA, EGFR 1.4211
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.3527
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B, SMAD3, CSNK2A1 1.3651
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.3527
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B, INSR, PPARA 1.3216
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1, NR3C1 1.3148
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2, EGFR 1.2986
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.2673
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, CSNK2A1, HSPA1A 1.0843
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1, PPARA 1.0944
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, HSPA1A 0.8952
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PGR, IGF1R 1.0017
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 0.9296
Melanogenesis_Homo sapiens_hsa04916 GSK3B, TYR 0.9914
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.0227
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.045
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8935
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.8935
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 1.0253
Insulin signaling pathway_Homo sapiens_hsa04910 GSK3B, INSR 0.8122
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.8897
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.0567
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8122
Cell cycle_Homo sapiens_hsa04110 GSK3B, SMAD3 0.87
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.7981
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2724
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 0.862
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3065
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1337
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.7535
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3162
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.3055
Tuberculosis_Homo sapiens_hsa05152 SRC 0.306
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B, SMAD3 0.7721
Influenza A_Homo sapiens_hsa05164 GSK3B, HSPA1A 0.6983
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, SRC 0.6568
Alzheimer's disease_Homo sapiens_hsa05010 GSK3B, APP 0.7228
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.6015
Endometrial cancer_Homo sapiens_hsa05213 GSK3B, EGFR 1.3651
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3198
HTLV-I infection_Homo sapiens_hsa05166 GSK3B, SMAD3 0.5194
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.2673
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3887
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.2613
Platelet activation_Homo sapiens_hsa04611 SRC 0.4147
Dopaminergic synapse_Homo sapiens_hsa04728 GSK3B 0.3986
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B 0.4173
Colorectal cancer_Homo sapiens_hsa05210 GSK3B, SMAD3 1.286
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4414
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3058
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4614
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4657
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4657
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B 0.4614
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4671
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4719
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.2673
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4713
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.4657
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4844
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.49
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4972
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.49
Small cell lung cancer_Homo sapiens_hsa05222 PTGS2 0.4919
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4892
Peroxisome_Homo sapiens_hsa04146 XDH 0.4983
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.529
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B 0.529
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR, NR3C2 1.5464
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.529
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5131
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5274
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5194
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.534
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5528
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5574
Shigellosis_Homo sapiens_hsa05131 SRC 0.555
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5786
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6015
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7217
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6015
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.6015
Malaria_Homo sapiens_hsa05144 MET 0.6347
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.6308
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6388
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6392
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6849
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6048
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6388
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9083
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7411
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.7411
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8122
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7734
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7918
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8122
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7825
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8122
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.2128
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 0.8935
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8687
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.9352
Folate biosynthesis_Homo sapiens_hsa00790 DHFR 1.0017
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.286


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)