TCM Prescription: Shen Xiang Su He Pills



Prescription Description
Prescription IDTCMF887
Pinyin NameShen Xiang Su He Wan 
Chinese Name神香苏合丸
English NameShen Xiang Su He Pills
Function Description小儿急惊, 抽搐吐乳, 目窜上视, 牙关紧闭, 痰涎潮壅, 危急诸症并治男妇中风痰厥, 昏迷僵仆, 寒证气闭, 霍乱吐泻, 时气瘴疟
IndicationsWind-phlegm pattern, Cold pattern, Severe vomiting and diarrhoea disorder, Stroke
Disease ICD-11 Category SF15 [Wind-phlegm pattern (TM1), 风痰证 (TM1) ];
SE73 [Cold pattern (TM1), 寒证 (TM1) ];
SD92 [Severe vomiting and diarrhoea disorder (TM1), 霍乱 (TM1) ];
8B20 [Stroke not known if ischaemic or haemorrhagic, 缺血或出血未知的卒中 ];
Human Tissues Associated with IndicationBrain
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1717 Moschus moschiferus 人工麝香 TCMH1717 GBMA2112-09
TCMH1999 Bubalus bubalis 水牛角浓缩粉 TCMH1999 GBMA0080-06
TCMH25 Styrax benzoin 安息香 TCMH25 CRCZ1380-16, CRCZ1353-16
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH249 Aquilaria agallocha 沉香 TCMH249 KU879012
TCMH2040 Liquidambar orientalis 苏合香 TCMH2040 GBVL2408-11, GBVL2411-11
TCMH183 Dryobalanops aromatica 冰片 TCMH183 GBVK4926-11
TCMH1753 Boswellia carterii 乳香 TCMH1753
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH486 Syzygium aromaticum 丁香 TCMH486 GBVI185-11
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT203 G6PD Glucose-6-phosphate 1-dehydrogenase Oxidoreductase P11413
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT243 ADRA2C Alpha-2c adrenergic receptor GPCR P18825
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT273 NR1H4 Bile acid receptor FXR Nuclear receptor Q96RI1
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT588 DAO D-amino-acid oxidase Oxidoreductase P14920
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT796 PCNA Proliferating cell nuclear antigen Unclassified P12004
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT864 THRA Thyroid hormone receptor alpha Nuclear receptor P10827
TCMT904 PGR Progesterone receptor Nuclear receptor P06401
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT974 GPER1 G-protein coupled estrogen receptor 1 GPCR Q99527
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1177 Haemophilus influenzae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1187 Enterococcus faecalis ATCC 29212
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1193 Staphylococcus
TCMT1194 Shigella sonnei
TCMT1195 Streptococcus pasteurianus
TCMT1196 Salmonella
TCMT1197 Shigella sp.
TCMT1198 Serratia marcescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1310 Enterococcus hirae
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, SRC, THRA, THRB 14.3606
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, SRC, THRA, THRB 12.8674
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR1H4, NR3C1, PGR, PIM1, PPARA, RORC, SRC, THRA, THRB 12.6049
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALPL, APEX1, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, NR1H4, NR3C1, PPARA, RORC, SMAD3, SRC, TEK, TYR 10.3551
[BP] GO:0048522 positive regulation of cellular process ACHE, ADRA2A, ADRA2C, AKR1B1, APEX1, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FLT3, GPER1, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, XDH 10.3543
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, THRA, THRB 10.3364
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, TYR, XDH 10.1888
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AR, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, GPER1, HSD17B2, IGF1R, INSR, MMP2, MMP9, NR1H4, NR3C1, PPARA, RORC, SRC, TEK, TYR 10.1888
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, ALPL, APEX1, AR, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GPER1, IGF1R, INSR, MMP2, NR1H4, NR3C1, PPARA, SMAD3, SRC, TEK 10.0121
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP2, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, TYR, XDH 9.80803
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, APEX1, AR, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GPER1, INSR, NR3C1, PPARA, SRC, TEK 9.51752
[BP] GO:0065008 regulation of biological quality ACHE, ADRA2A, ADRA2C, AKR1B1, APEX1, AR, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPER1, GPR35, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, INSR, KDR, MET, MIF, NR1H4, PPARA, SMAD3, SRC, TEK, THRA, THRB, XDH 9.31845
[BP] GO:0048518 positive regulation of biological process ACHE, ADRA2A, ADRA2C, AKR1B1, APEX1, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GPER1, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, XDH 9.16077
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, THRA, THRB 9.16077
[BP] GO:0033993 response to lipid ALPL, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GPER1, HSD17B2, NR1H4, NR3C1, RORC, SRC, TYR 8.91327
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, ALPL, APEX1, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR1H4, NR3C1, PPARA, RORC, SMAD3, SRC, TEK, TYR 8.82264
[BP] GO:0010941 regulation of cell death AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, GPER1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, NR1H4, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, THRA, TOP2A, XDH 8.72569
[BP] GO:0010647 positive regulation of cell communication ADRA2A, ADRA2C, AKR1B1, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPER1, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, PTPN1, SMAD3, SRC, TEK, XDH 8.69622
[BP] GO:0043067 regulation of programmed cell death AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, GPER1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, NR1H4, PIM1, PTPN1, SMAD3, SRC, TEK, THRA, TOP2A, XDH 8.68998
[BP] GO:0023056 positive regulation of signaling ADRA2A, ADRA2C, AKR1B1, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPER1, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, PTPN1, SMAD3, SRC, TEK, XDH 8.6807
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSD17B3, INSR, KDR, PPARA, SMAD3, SRC, TEK, THRA, TYR 8.52134
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, NR1H4 8.31475
[BP] GO:0042127 regulation of cell proliferation ADRA2A, AKR1B1, AR, CDC25B, CSNK2A1, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PGR, PIM1, SMAD3, SRC, TEK, XDH 8.05184
[BP] GO:0042981 regulation of apoptotic process AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, GPER1, HSPA1A, IGF1R, KDR, MIF, MMP9, NR1H4, PIM1, PTPN1, SMAD3, SRC, TEK, THRA, TOP2A, XDH 8.05184
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, AR, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, GPER1, NR3C1, RORC, SRC, TEK, TYR 8.04461
[BP] GO:1902531 regulation of intracellular signal transduction ADRA2A, ADRA2C, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPER1, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, NR1H4, NUAK1, PTPN1, SRC, TEK, XDH 7.80368
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, FABP3, FUT7, GLO1, HSD17B3, HSPA1A, MIF, NR1H4, PIM1, PPARA, TYR, XDH 7.61458
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, HSD17B3, MET, MIF, NR1H4, PPARA 7.61458
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, TYR, XDH 7.61458
[BP] GO:0010817 regulation of hormone levels ACHE, ADRA2A, ADRA2C, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, GPER1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, NR1H4 7.55318
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALPL, APEX1, AR, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR1H4, NR3C1, RORC, SMAD3, SRC 7.43282
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2, HSD17B3 7.34277
[BP] GO:0009967 positive regulation of signal transduction ADRA2A, ADRA2C, AKR1B1, AR, AXL, CSNK2A1, CYP1B1, EGFR, F10, FLT3, GPER1, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, PTPN1, SMAD3, SRC, TEK, XDH 7.28208
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALPL, APEX1, AR, AURKB, AXL, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, HSD17B3, INSR, KDR, MET, MIF, MMP2, MMP9, PGR, PIM1, PPARA, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, TYR 7.2331
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADRA2A, ADRA2C, AR, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, XDH 7.05844
[BP] GO:0060548 negative regulation of cell death AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, NR1H4, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 7.0393
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2, HSD17B3 6.95621
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.95361
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALPL, APEX1, AR, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MIF, MMP2, MMP9, NR1H4, NR3C1, NUAK1, PTPN1, RORC, SMAD3, SRC, TOP2A 6.94783
[BP] GO:1902533 positive regulation of intracellular signal transduction ADRA2A, ADRA2C, AKR1B1, AR, AXL, CYP1B1, EGFR, F10, FLT3, GPER1, GPR35, HSPA1A, INSR, KDR, MET, MIF, PTPN1, SRC, TEK, XDH 6.88187
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, NR1H4, PIM1, PTPN1, SMAD3, SRC, TEK 6.88071
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALPL, APEX1, AR, AXL, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, GPER1, IGF1R, INSR, KDR, MMP2, NR1H4, NR3C1, RORC, SMAD3, SRC 6.86159
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, TYR, XDH 6.86159
[BP] GO:0010646 regulation of cell communication ACHE, ADRA2A, ADRA2C, AKR1B1, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, FLT3, GPER1, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NUAK1, PTPN1, SMAD3, SRC, TEK, THRA, XDH 6.79514
[BP] GO:0048523 negative regulation of cellular process ACHE, ADRA2A, ADRA2C, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPER1, GPR35, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, XDH 6.72106
[BP] GO:0031325 positive regulation of cellular metabolic process ADRA2A, ADRA2C, AR, AURKB, CDC25B, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, XDH 6.71947
[BP] GO:0023051 regulation of signaling ACHE, ADRA2A, ADRA2C, AKR1B1, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, FLT3, GPER1, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NUAK1, PTPN1, SMAD3, SRC, TEK, THRA, XDH 6.67734
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADRA2A, ADRA2C, AR, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, XDH 6.67734
[BP] GO:0009893 positive regulation of metabolic process ADRA2A, ADRA2C, AR, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, XDH 6.49075
[BP] GO:0048584 positive regulation of response to stimulus ADRA2A, ADRA2C, AKR1B1, AR, AXL, CSNK2A1, CYP1B1, EGFR, ESRRA, F10, FABP4, FLT3, GPER1, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, NR1H4, PTPN1, SMAD3, SRC, TEK, XDH 6.2533
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MIF, MMP9, NR1H4, PIM1, PTPN1, SMAD3, SRC, TEK 6.215
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, HSD17B3 6.04826
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.02122
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, AR, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, GPER1, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, PIM1, TEK 5.99735
[BP] GO:0048519 negative regulation of biological process ACHE, ADRA2A, ADRA2C, AKR1B1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPER1, GPR35, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, XDH 5.99034
[BP] GO:0032501 multicellular organismal process ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX5, ALPL, AR, AXL, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, F10, FABP4, GPER1, HSD17B2, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, THRA, THRB, TYR 5.95436
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.93572
[BP] GO:0010648 negative regulation of cell communication ACHE, ADRA2A, ADRA2C, AR, DUSP3, EGFR, ESR1, ESR2, GPER1, GPR35, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, NR1H4, PTPN1, SMAD3, SRC, XDH 5.75611
[BP] GO:0032879 regulation of localization ACHE, ADRA2A, ADRA2C, APEX1, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, GPER1, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, PPARA, PTPN1, SMAD3, SRC, TEK, THRA 5.74305
[BP] GO:0023057 negative regulation of signaling ACHE, ADRA2A, ADRA2C, AR, DUSP3, EGFR, ESR1, ESR2, GPER1, GPR35, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, NR1H4, PTPN1, SMAD3, SRC, XDH 5.74305
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, AR, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, GPER1, NR3C1, RORC, SRC 5.7173
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AR, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSPA1A, IGF1R, INSR, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, THRA, THRB, TOP2A 5.6321
[BP] GO:0019220 regulation of phosphate metabolic process ADRA2A, ADRA2C, AR, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GPER1, IGF1R, INSR, KDR, MIF, MMP9, NR1H4, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.55873
[BP] GO:0051174 regulation of phosphorus metabolic process ADRA2A, ADRA2C, AR, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GPER1, IGF1R, INSR, KDR, MIF, MMP9, NR1H4, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.49586
[BP] GO:0009966 regulation of signal transduction ADRA2A, ADRA2C, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, FLT3, GPER1, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NUAK1, PTPN1, SMAD3, SRC, TEK, THRA, XDH 5.38909
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AR, AXL, CYP1B1, EGFR, ESR1, GPER1, IGF1R, INSR, MMP2, MMP9, NR1H4, NR3C1, RORC, SRC 5.38512
[BP] GO:0022414 reproductive process ADRA2C, AKR1B1, ALPL, AR, AXL, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD17B2, HSD17B3, INSR, MMP2, MMP9, PGR, SRC, THRA, THRB, TOP2A 5.38191
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, GPER1, NR3C1, PGR, SRC 5.38109
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADRA2A, ADRA2C, AR, CDC25B, EGFR, ESRRB, FABP3, FLT3, GPER1, INSR, KDR, MIF, MMP9, NR1H4, PTPN1, SMAD3, SRC, TEK, XDH 5.38109
[BP] GO:0045937 positive regulation of phosphate metabolic process ADRA2A, ADRA2C, AR, CDC25B, EGFR, ESRRB, FABP3, FLT3, GPER1, INSR, KDR, MIF, MMP9, NR1H4, PTPN1, SMAD3, SRC, TEK, XDH 5.38109
[BP] GO:0048583 regulation of response to stimulus ADRA2A, ADRA2C, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, FABP4, FLT3, GPER1, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, NR1H4, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, THRA, XDH 5.32735
[BP] GO:0050896 response to stimulus ACHE, ADRA2A, AKR1B1, ALPL, APEX1, AR, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, F10, FABP3, FABP4, FLT3, GPER1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NR1H4, NR3C1, NUAK1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, TOP2A, TYR 5.28549
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AR, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, IGF1R, INSR, KDR, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, THRA, THRB, TOP2A 5.28549
[BP] GO:0009891 positive regulation of biosynthetic process AR, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, GPER1, IGF1R, INSR, KDR, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, THRA, THRB, TOP2A 5.28549
[BP] GO:0030334 regulation of cell migration ADRA2A, APEX1, CYP19A1, CYP1B1, EGFR, F10, GPER1, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 5.28549
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, HSD11B1, HSD17B1, HSD17B2, HSD17B3, TYR, XDH 5.20573
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APEX1, AR, EGFR, ESR1, FLT3, GPER1, IGF1R, INSR, MMP2, NR1H4, NR3C1, SMAD3, SRC 5.16981
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.15413
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 5.11683
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.10647
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALPL, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSD17B3, INSR, KDR, MMP9, PGR, PIM1, PPARA, RORC, SMAD3, SRC, TEK, THRA, TYR 5.05115
[BP] GO:0043410 positive regulation of MAPK cascade ADRA2A, ADRA2C, AR, EGFR, FLT3, GPER1, INSR, KDR, MIF, PTPN1, SRC, TEK, XDH 4.97427
[BP] GO:2000145 regulation of cell motility ADRA2A, APEX1, CYP19A1, CYP1B1, EGFR, F10, GPER1, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 4.95497
[BP] GO:0043408 regulation of MAPK cascade ADRA2A, ADRA2C, AR, DUSP3, EGFR, FLT3, GPER1, IGF1R, INSR, KDR, MIF, PTPN1, SRC, TEK, XDH 4.92613
[BP] GO:0080134 regulation of response to stress ADRA2A, CYP19A1, DUSP3, EGFR, ESR1, FABP4, GPER1, HSPA1A, IGF1R, MET, MIF, MMP12, MMP2, NR1H4, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.92613
[BP] GO:0009892 negative regulation of metabolic process ADRA2A, APEX1, AR, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GPER1, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, THRA, THRB, XDH 4.83312
[BP] GO:0051254 None AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSPA1A, INSR, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, THRA, THRB, TOP2A 4.83312
[BP] GO:0048585 negative regulation of response to stimulus ADRA2A, AR, CYP19A1, DUSP3, EGFR, ESR1, ESR2, GPER1, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, NR1H4, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.81694
[BP] GO:0031328 positive regulation of cellular biosynthetic process AR, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, GPER1, IGF1R, INSR, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, THRA, THRB, TOP2A 4.81444
[BP] GO:0030335 positive regulation of cell migration ADRA2A, EGFR, F10, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.77198
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, GPER1, INSR, MET, SRC, TEK, XDH 4.74563
[BP] GO:0019216 regulation of lipid metabolic process ADRA2A, CYP1A1, FABP3, FLT3, GPER1, NR1H4, PPARA, RORC, SRC, TEK, THRA 4.69766
[BP] GO:2000147 positive regulation of cell motility ADRA2A, EGFR, F10, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.61573
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC 4.57854
[BP] GO:0051172 None ADRA2A, APEX1, AR, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GPER1, HSPA1A, IGF1R, MIF, MMP12, MMP9, NR1H4, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, THRA, THRB, XDH 4.54833
[BP] GO:0040012 regulation of locomotion ADRA2A, APEX1, CYP19A1, CYP1B1, EGFR, F10, GPER1, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 4.53837
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.53837
[BP] GO:0045893 None AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, INSR, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, THRA, THRB, TOP2A 4.53293
[BP] GO:1903508 None AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, INSR, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, THRA, THRB, TOP2A 4.53293
[BP] GO:1902680 None AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, INSR, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, THRA, THRB, TOP2A 4.53293
[BP] GO:0051270 regulation of cellular component movement ADRA2A, APEX1, CYP19A1, CYP1B1, EGFR, F10, GPER1, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 4.53293
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, EGFR, F10, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.52231
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, AR, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GPER1, HSPA1A, IGF1R, KDR, MIF, MMP12, MMP9, NR1H4, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, THRA, THRB, XDH 4.51709
[BP] GO:0080090 regulation of primary metabolic process ADRA2A, ADRA2C, APEX1, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, XDH 4.42159
[BP] GO:0040017 positive regulation of locomotion ADRA2A, EGFR, F10, GPER1, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.37009
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, AR, DUSP3, EGFR, ESR1, ESR2, GPER1, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, NR1H4, PTPN1, SMAD3, SRC, XDH 4.32167
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 4.27305
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, HSD17B3, INSR, PGR, SRC 4.27226
[BP] GO:0071383 None AR, EGFR, FLT3, GPER1, NR3C1, SRC 4.2582
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADRA2A, ADRA2C, APEX1, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, XDH 4.23773
[BP] GO:0019222 regulation of metabolic process ACHE, ADRA2A, ADRA2C, APEX1, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, XDH 4.22797
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADRA2A, ADRA2C, APEX1, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, GLO1, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, XDH 4.19599
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADRA2A, ADRA2C, APEX1, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, XDH 4.1686
[BP] GO:0042592 homeostatic process ADRA2A, AKR1B1, APEX1, AXL, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, FLT3, GPER1, GPR35, INSR, MET, NR1H4, SMAD3, SRC 4.14708
[BP] GO:0042325 regulation of phosphorylation ADRA2A, ADRA2C, AR, CDC25B, DUSP3, EGFR, ESRRB, FABP4, FLT3, GPER1, IGF1R, INSR, KDR, MIF, MMP9, PPARA, PTPN1, SRC, TEK, XDH 4.14708
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, HSD17B3 4.14708
[BP] GO:1902532 negative regulation of intracellular signal transduction DUSP3, ESR1, GPER1, HSPA1A, IGF1R, MET, MIF, MMP9, NR1H4, PTPN1, SRC, XDH 4.13967
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, APEX1, AR, AURKB, CSNK2A1, DUSP3, ESR1, ESR2, ESRRA, FABP4, GPER1, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, NR1H4, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, THRA, THRB, XDH 4.0824
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, NR1H4, SRC, TEK 4.0824
[BP] GO:0032870 cellular response to hormone stimulus ADRA2A, APEX1, AR, EGFR, ESR1, FLT3, GPER1, INSR, NR3C1, SRC 4.04732
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ADRA2C, AR, AXL, CA2, CYP1B1, EGFR, ESRRB, GPER1, HSPA1A, KDR, MET, MIF, MMP12, MMP9, NR1H4, PIM1, SMAD3, SRC, TEK 4.02997
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 4.01604
[BP] GO:0042327 positive regulation of phosphorylation ADRA2A, ADRA2C, AR, CDC25B, EGFR, ESRRB, FLT3, GPER1, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 4.01604
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, EGFR, FABP3, FLT3, GPER1, IGF1R, INSR, MMP2, NR1H4, PPARA, SRC, TEK, TYR 3.94408
[BP] GO:0007165 signal transduction ADRA2A, ADRA2C, AKR1B1, AR, AXL, CA1, CA2, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GPR35, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB 3.93492
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DAO, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 3.92803
[BP] GO:0071396 cellular response to lipid AR, AXL, EGFR, ESR1, FLT3, GPER1, NR1H4, NR3C1, RORC, SRC 3.92803
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.92078
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CYP1A1, EGFR, ESR1, FLT3, MET, MIF, PIM1, SRC, TEK, TYR 3.91666
[BP] GO:0045934 None ADRA2A, APEX1, AR, AURKB, ESR1, ESR2, ESRRA, FABP4, GPER1, HSPA1A, MMP12, NR1H4, NR3C1, PPARA, RORC, SMAD3, SRC, THRA, THRB 3.8748
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, EGFR, ESR1, PGR, PPARA, RORC, SRC, TOP2A 3.80826
[BP] GO:0000122 None AR, AURKB, ESR1, ESR2, ESRRA, HSPA1A, MMP12, NR1H4, NR3C1, PPARA, RORC, SMAD3, THRA, THRB 3.80826
[BP] GO:0031347 regulation of defense response CYP19A1, EGFR, ESR1, FABP4, GPER1, HSPA1A, MMP12, MMP2, NR1H4, PPARA, PTPN1, SMAD3, SRC, TEK 3.79128
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, GPER1, INSR, MIF, SRC 3.78684
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 3.78634
[BP] GO:0010676 None ESRRB, GPER1, INSR, PPARA, SRC 3.72122
[BP] GO:1903507 None APEX1, AR, AURKB, ESR1, ESR2, ESRRA, FABP4, HSPA1A, MMP12, NR1H4, NR3C1, PPARA, RORC, SMAD3, SRC, THRA, THRB 3.70943
[BP] GO:1902679 None APEX1, AR, AURKB, ESR1, ESR2, ESRRA, FABP4, HSPA1A, MMP12, NR1H4, NR3C1, PPARA, RORC, SMAD3, SRC, THRA, THRB 3.70375
[BP] GO:0010629 None AR, AURKB, ESR1, ESR2, ESRRA, FABP4, GPER1, HSPA1A, KDR, MIF, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, THRA, THRB, XDH 3.70375
[BP] GO:0048545 response to steroid hormone ALPL, AR, CA2, EGFR, FLT3, GPER1, NR3C1, SRC 3.6828
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, SRC, TEK 3.6828
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AR, AXL, CDC25B, CYP1A1, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GLO1, KDR, MET, MIF, MMP2, MMP9, PGR, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A 3.64949
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.64949
[BP] GO:0006357 None AR, AURKB, CA9, EGFR, ESR1, ESR2, ESRRA, ESRRB, GLO1, GPER1, HSPA1A, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, THRA, THRB, TOP2A 3.62168
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GPER1, GPR35, INSR, MET, NR1H4, SMAD3 3.61769
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, EGFR, FABP3, FLT3, GPER1, IGF1R, INSR, MMP2, NR1H4, PPARA, SRC, TEK, TYR 3.61507
[BP] GO:0001934 positive regulation of protein phosphorylation ADRA2A, ADRA2C, AR, CDC25B, EGFR, FLT3, GPER1, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 3.61105
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, TYR, XDH 3.60061
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.59356
[BP] GO:0065009 regulation of molecular function ADRA2A, ADRA2C, AR, AURKB, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GPER1, GPR35, HSPA1A, IGF1R, INSR, MET, MIF, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.54596
[BP] GO:0051239 regulation of multicellular organismal process ADRA2A, ADRA2C, AR, AXL, CA2, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, GPER1, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, NR1H4, PIM1, SMAD3, SRC, TEK, THRA, THRB, XDH 3.53439
[BP] GO:0010628 positive regulation of gene expression AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSPA1A, INSR, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, THRA, THRB, TOP2A 3.53439
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.53286
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, FUT7, MET, MIF, PPARA 3.52874
[BP] GO:0045944 None AR, EGFR, ESR1, ESRRA, ESRRB, GPER1, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, SMAD3, THRA, THRB, TOP2A 3.52759
[BP] GO:0001932 regulation of protein phosphorylation ADRA2A, ADRA2C, AR, CDC25B, DUSP3, EGFR, FABP4, FLT3, GPER1, IGF1R, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 3.52129
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 3.4612
[BP] GO:0051049 regulation of transport ACHE, ADRA2A, ADRA2C, AXL, CA2, CA7, CYP19A1, EGFR, GPER1, GPR35, HSPA1A, INSR, MIF, MMP12, MMP9, NR1H4, PPARA, PTPN1, SMAD3, SRC, THRA 3.45616
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DAO, HSD17B3, NR1H4, TYR 3.43112
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1, HSD17B3 3.41285
[BP] GO:0048732 gland development AR, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, THRA, TYR 3.41285
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, NR1H4, PPARA 3.40054
[BP] GO:0031348 negative regulation of defense response CYP19A1, GPER1, MMP12, NR1H4, PPARA, SMAD3, TEK 3.39906
[BP] GO:0051253 None APEX1, AR, AURKB, ESR1, ESR2, ESRRA, FABP4, HSPA1A, MMP12, NR1H4, NR3C1, PPARA, RORC, SMAD3, SRC, THRA, THRB 3.38548
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 3.35545
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, EGFR, HSPA1A 3.34275
[BP] GO:0045892 None AR, AURKB, ESR1, ESR2, ESRRA, FABP4, HSPA1A, MMP12, NR1H4, NR3C1, PPARA, RORC, SMAD3, SRC, THRA, THRB 3.34275
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, NR1H4, SRC, TEK, TOP2A 3.33637
[BP] GO:0001503 ossification ALPL, EGFR, MMP2, MMP9, TEK, THRA 3.3328
[BP] GO:0044093 positive regulation of molecular function ADRA2A, ADRA2C, AR, AURKB, CDC25B, EGFR, ESR1, ESR2, FLT3, GPER1, HSPA1A, INSR, MET, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.31486
[BP] GO:0050728 negative regulation of inflammatory response CYP19A1, GPER1, NR1H4, PPARA, SMAD3, TEK 3.31486
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, NR3C1, SRC 3.30875
[BP] GO:0043405 regulation of MAP kinase activity ADRA2A, DUSP3, EGFR, FLT3, IGF1R, INSR, MIF, PTPN1, SRC 3.27943
[BP] GO:0045913 None ESRRB, GPER1, INSR, PPARA, SRC 3.23825
[BP] GO:0044092 negative regulation of molecular function ADRA2A, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, NR1H4, PIM1, PPARA, PTPN1, SRC 3.23643
[BP] GO:0031399 regulation of protein modification process ADRA2A, ADRA2C, AR, CDC25B, DUSP3, EGFR, FABP4, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 3.2297
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.22521
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HSD17B3 3.21666
[BP] GO:0051247 positive regulation of protein metabolic process ADRA2A, ADRA2C, AR, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, GPER1, HSPA1A, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.20933
[BP] GO:0010675 None ESRRB, GPER1, INSR, PPARA, RORC, SRC 3.20684
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, GPER1, IGF1R, INSR, PPARA, SRC, TEK 3.2054
[BP] GO:0032101 regulation of response to external stimulus CYP19A1, EGFR, ESR1, FABP4, GPER1, KDR, MET, MIF, MMP12, NR1H4, PPARA, SMAD3, TEK 3.19048
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, HSD17B3, MIF 3.1902
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.17905
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, NR1H4, PPARA, SRC, TEK 3.17905
[BP] GO:0050790 regulation of catalytic activity ADRA2A, ADRA2C, AR, AURKB, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, GPER1, HSPA1A, IGF1R, INSR, MIF, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 3.16075
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 3.15753
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, NR1H4, SRC, TEK 3.14798
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 3.14612
[BP] GO:0032148 None ADRA2A, ADRA2C, INSR, SRC 3.1361
[BP] GO:0048608 reproductive structure development AR, AXL, CYP19A1, ESR1, HSD17B2, HSD17B3, INSR, SRC 3.13455
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 3.11999
[BP] GO:0065007 biological regulation ACHE, ADRA2A, ADRA2C, AKR1B1, APEX1, AR, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GLO1, GPER1, GPR35, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, XDH 3.10033
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade DUSP3, EGFR, GPER1, KDR, MIF, PTPN1, SRC, TEK 3.0952
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.0734
[BP] GO:0090087 None ACHE, ADRA2A, ADRA2C, CA2, EGFR, GPER1, MIF, MMP12, NR1H4, PTPN1, SMAD3, SRC, THRA 3.05264
[BP] GO:0009890 None ADRA2A, APEX1, AR, AURKB, ESR1, ESR2, ESRRA, FABP4, GPER1, HSPA1A, MMP12, NR1H4, NR3C1, PPARA, RORC, SMAD3, SRC, THRA, THRB 3.05077
[BP] GO:0002009 morphogenesis of an epithelium AR, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 3.01495
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, EGFR, KDR, NR3C1, SRC 3.01495
[BP] GO:0045742 None ADRA2A, ADRA2C, GPER1, MMP9 3.00764
[BP] GO:0032844 regulation of homeostatic process ADRA2A, AURKB, CA2, CA7, EGFR, GPER1, KDR, MIF, NR1H4, SRC 3.00389
[BP] GO:0019219 regulation of nucleobase-containing compound metabolic process ADRA2A, APEX1, AR, AURKB, CA9, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, GPER1, HSPA1A, IGF1R, INSR, MET, MMP12, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, THRA, THRB, TOP2A 3.00381
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADRA2A, ADRA2C, AR, CDC25B, EGFR, ESR1, FLT3, GPER1, HSPA1A, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 2.9992
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.97087
[BP] GO:0006355 regulation of transcription, DNA-templated APEX1, AR, AURKB, CA9, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, GPER1, HSPA1A, INSR, MET, MMP12, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SMAD3, SRC, THRA, THRB, TOP2A 2.94319
[BP] GO:1901655 None AKR1B1, AR, EGFR, NR3C1, SRC 2.94042
[BP] GO:1901186 None ADRA2A, ADRA2C, GPER1, MMP9 2.93644
[BP] GO:0008050 None THRA, THRB 2.93644
[BP] GO:0009115 None AOX1, XDH 2.93644
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.93014
[BP] GO:1903506 regulation of nucleic acid-templated transcription APEX1, AR, AURKB, CA9, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, GPER1, HSPA1A, INSR, MET, MMP12, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SMAD3, SRC, THRA, THRB, TOP2A 2.93014
[BP] GO:2001141 regulation of RNA biosynthetic process APEX1, AR, AURKB, CA9, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, GPER1, HSPA1A, INSR, MET, MMP12, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SMAD3, SRC, THRA, THRB, TOP2A 2.92057
[BP] GO:0050727 regulation of inflammatory response CYP19A1, EGFR, ESR1, FABP4, GPER1, NR1H4, PPARA, SMAD3, TEK 2.91457
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 2.91373
[BP] GO:0043549 regulation of kinase activity ADRA2A, ADRA2C, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, MIF, PTPN1, SRC, TEK 2.89448
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, EGFR, GPER1, IGF1R, INSR, MMP2, NR1H4, SRC 2.85945
[BP] GO:0009987 cellular process ACHE, ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GPER1, GPR35, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, TYR, XDH 2.85097
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.84375
[BP] GO:0042058 None ADRA2A, ADRA2C, EGFR, GPER1, MMP9 2.84245
[BP] GO:0050793 regulation of developmental process ADRA2C, AR, AXL, CA2, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, GPER1, INSR, KDR, MIF, NR1H4, NUAK1, PIM1, PPARA, RORC, SMAD3, SRC, TEK, THRA, XDH 2.79719
[BP] GO:0009889 regulation of biosynthetic process ADRA2A, APEX1, AR, AURKB, CA9, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SMAD3, SRC, THRA, THRB, TOP2A 2.77553
[BP] GO:0051338 regulation of transferase activity ADRA2A, ADRA2C, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, MIF, PTPN1, SRC, TEK 2.74914
[BP] GO:0051726 regulation of cell cycle APEX1, AURKB, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, GPER1, HSPA1A, INSR, MIF, PIM1, SMAD3, SRC, TOP2A 2.70666
[BP] GO:0031960 response to corticosteroid ALPL, EGFR, FLT3, GPER1, NR3C1, SRC 2.70307
[BP] GO:0003018 None ADRA2A, ADRA2C, EGFR, GPER1, SRC, TEK 2.70307
[BP] GO:0050730 None ADRA2A, ADRA2C, EGFR, FLT3, MIF, PTPN1, SRC 2.70219
[BP] GO:0032880 regulation of protein localization ACHE, ADRA2A, ADRA2C, AR, CSNK2A1, EGFR, GPER1, MIF, MMP12, NR1H4, PTPN1, SMAD3, SRC, THRA 2.69868
[BP] GO:0051130 positive regulation of cellular component organization AR, AURKB, AXL, ESR1, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.69404
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.6848
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, NR1H4, SRC 2.67589
[BP] GO:0050714 None ACHE, EGFR, GPER1, MIF, MMP12, NR1H4, SRC 2.66288
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway HSPA1A, MIF, MMP9, PTPN1, SRC 2.66288
[BP] GO:0050708 None ACHE, ADRA2A, ADRA2C, EGFR, GPER1, MIF, MMP12, NR1H4, SRC 2.6554
[BP] GO:0010906 None ESRRB, INSR, PPARA, RORC, SRC 2.64382
[BP] GO:0031327 None ADRA2A, APEX1, AR, AURKB, ESR1, ESR2, ESRRA, FABP4, HSPA1A, MMP12, NR1H4, NR3C1, PPARA, RORC, SMAD3, SRC, THRA, THRB 2.63466
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, EGFR, GPER1, IGF1R, INSR, MMP2, NR1H4, SRC 2.62789
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF 2.62784
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, GPER1, KDR, TEK 2.62784
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, CYP19A1, CYP3A4, DAO, HSD17B3, TYR 2.61697
[BP] GO:0050678 None AR, EGFR, KDR, MMP12, PGR, SMAD3, TEK, XDH 2.61597
[BP] GO:0051223 None ACHE, ADRA2A, ADRA2C, EGFR, GPER1, MIF, MMP12, NR1H4, PTPN1, SMAD3, SRC, THRA 2.61083
[BP] GO:0009894 regulation of catabolic process ADRA2A, APEX1, CSNK2A1, EGFR, ESRRB, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3, THRA 2.60874
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TOP2A 2.60651
[BP] GO:1901184 None ADRA2A, ADRA2C, EGFR, GPER1, MMP9 2.59499
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, NR1H4, PPARA 2.58857
[BP] GO:0045859 regulation of protein kinase activity ADRA2A, ADRA2C, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, MIF, PTPN1, SRC 2.58163
[BP] GO:0000904 cell morphogenesis involved in differentiation AR, AXL, MET, SRC, TEK 2.57814
[BP] GO:0033674 positive regulation of kinase activity ADRA2A, ADRA2C, CDC25B, EGFR, FLT3, INSR, MIF, PTPN1, SRC, TEK 2.57258
[BP] GO:0031401 positive regulation of protein modification process ADRA2A, ADRA2C, AR, CDC25B, EGFR, FLT3, GPER1, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 2.57084
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, AR, AXL, CYP1A1, EGFR, ESR1, PGR, SRC, THRA, THRB 2.5669
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.5669
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.5669
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.5669
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.5669
[BP] GO:0031326 regulation of cellular biosynthetic process ADRA2A, APEX1, AR, AURKB, CA9, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPER1, HSPA1A, IGF1R, INSR, MET, MMP12, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SMAD3, SRC, THRA, THRB, TOP2A 2.55971
[BP] GO:0060748 None AR, PGR 2.55302
[BP] GO:0046110 None AOX1, XDH 2.55302
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.55302
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.52732
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF 2.51654
[BP] GO:0051252 regulation of RNA metabolic process APEX1, AR, AURKB, CA9, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, GPER1, HSPA1A, INSR, MET, MMP12, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SMAD3, SRC, THRA, THRB, TOP2A 2.51652
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADRA2A, ADRA2C, FLT3, MIF, PTPN1, SRC 2.49276
[BP] GO:0002793 None ACHE, EGFR, GPER1, MIF, MMP12, NR1H4, SRC 2.49179
[BP] GO:0010468 regulation of gene expression APEX1, AR, AURKB, CA9, CSNK2A1, CYP1A2, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, GPER1, HSPA1A, INSR, KDR, MET, MIF, MMP12, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SMAD3, SRC, THRA, THRB, TOP2A, XDH 2.49179
[BP] GO:0002791 None ACHE, ADRA2A, ADRA2C, EGFR, GPER1, MIF, MMP12, NR1H4, SRC 2.49179
[BP] GO:0051347 positive regulation of transferase activity ADRA2A, ADRA2C, AURKB, CDC25B, EGFR, FLT3, INSR, MIF, PTPN1, SRC, TEK 2.49179
[BP] GO:0006109 regulation of carbohydrate metabolic process ESRRB, GPER1, INSR, PPARA, RORC, SRC 2.48915
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.4846
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.4846
[BP] GO:0010556 regulation of macromolecule biosynthetic process APEX1, AR, AURKB, CA9, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SMAD3, SRC, THRA, THRB, TOP2A 2.46189
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.45864
[BP] GO:0048729 tissue morphogenesis AR, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.44624
[BP] GO:0001775 cell activation ADRA2A, ADRA2C, ALOX5, AXL, EGFR, FLT3, FUT7, HSPA1A, MIF, MMP9, RORC, SMAD3, SRC 2.44624
[BP] GO:0070201 None ACHE, ADRA2A, ADRA2C, EGFR, GPER1, MIF, MMP12, NR1H4, PTPN1, SMAD3, SRC, THRA 2.4457
[BP] GO:1903532 None ACHE, CYP19A1, EGFR, GPER1, MIF, MMP12, NR1H4, SRC 2.44058
[BP] GO:0051050 positive regulation of transport ACHE, ADRA2A, AXL, CA2, CYP19A1, EGFR, GPER1, INSR, MIF, MMP12, NR1H4, SMAD3, SRC 2.43156
[BP] GO:0009058 None ACHE, AKR1B1, ALOX5, APEX1, AR, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSD11B1, HSD17B1, HSD17B2, HSD17B3, MIF, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, SMAD3, THRA, THRB, TYR 2.42643
[BP] GO:0010558 None APEX1, AR, AURKB, ESR1, ESR2, ESRRA, FABP4, HSPA1A, MMP12, NR1H4, NR3C1, PPARA, RORC, SMAD3, SRC, THRA, THRB 2.42479
[BP] GO:0043406 positive regulation of MAP kinase activity ADRA2A, EGFR, FLT3, INSR, MIF, PTPN1, SRC 2.42016
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.41038
[BP] GO:0051094 positive regulation of developmental process ADRA2C, AR, AXL, CA2, CYP1B1, ESRRB, GPER1, INSR, KDR, NR1H4, PIM1, SMAD3, SRC, TEK, THRA 2.40714
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.40031
[BP] GO:0043085 positive regulation of catalytic activity ADRA2A, ADRA2C, AURKB, CDC25B, EGFR, ESR1, FLT3, GPER1, HSPA1A, INSR, MIF, PTPN1, SMAD3, SRC, TEK, XDH 2.39354
[BP] GO:1901360 None ACHE, AKR1B1, AKR1B10, AOX1, APEX1, AR, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, ESR1, ESR2, ESRRA, ESRRB, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, SMAD3, THRA, THRB, TOP2A, TYR, XDH 2.38559
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, RORC 2.36731
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.36731
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4 2.35976
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.34621
[BP] GO:0071384 None EGFR, FLT3, GPER1, NR3C1 2.33606
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, MIF, NR1H4, PPARA 2.33606
[BP] GO:0044249 None ACHE, AKR1B1, ALOX5, APEX1, AR, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, HSD17B2, HSD17B3, MIF, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, SMAD3, THRA, THRB, TYR 2.31851
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.3181
[BP] GO:0035625 None ADRA2A, ADRA2C 2.3181
[BP] GO:0032811 None ADRA2A, ADRA2C 2.3181
[BP] GO:0006145 None AOX1, XDH 2.3181
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.3181
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.3181
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, DAO, FABP3, GLO1, MIF, NR1H4, PIM1, PPARA, TYR 2.31265
[BP] GO:0043434 None APEX1, FABP3, GPER1, INSR, PPARA, SRC, TEK 2.31124
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.30754
[BP] GO:0032102 negative regulation of response to external stimulus CYP19A1, GPER1, MIF, NR1H4, PPARA, SMAD3, TEK 2.30376
[BP] GO:0009628 response to abiotic stimulus AKR1B1, AURKB, CA2, CYP1A1, EGFR, HSPA1A, MMP2, PPARA, SMAD3, SRC, TEK, THRA, TYR 2.29434
[BP] GO:2000112 regulation of cellular macromolecule biosynthetic process APEX1, AR, AURKB, CA9, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, GPER1, HSPA1A, IGF1R, INSR, MET, MMP12, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, SMAD3, SRC, THRA, THRB, TOP2A 2.29434
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.29072
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.28248
[BP] GO:2001233 regulation of apoptotic signaling pathway AR, GPER1, HSPA1A, MIF, MMP9, PTPN1, SMAD3, SRC 2.28209
[BP] GO:0051047 None ACHE, CYP19A1, EGFR, GPER1, MIF, MMP12, NR1H4, SRC 2.27734
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, EGFR, FABP3, KDR, NR3C1, SRC 2.27734
[BP] GO:0051128 regulation of cellular component organization AR, AURKB, AXL, CSNK2A1, EGFR, ESR1, ESR2, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PTPN1, SMAD3, SRC, TEK, THRA, TOP2A 2.26661
[BP] GO:0051894 None KDR, SMAD3, TEK 2.26518
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.26518
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade EGFR, GPER1, KDR, MIF, SRC, TEK 2.25924
[BP] GO:0010638 positive regulation of organelle organization AURKB, GPER1, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.25055
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, GPER1 2.23675
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.23675
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.22442
[BP] GO:0032268 regulation of cellular protein metabolic process ADRA2A, ADRA2C, AR, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.22442
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADRA2A, DUSP3, EGFR, FLT3, IGF1R, INSR, MIF, PTPN1, SRC 2.21621
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling FLT3, GPER1, KDR, TEK 2.21621
[BP] GO:1900076 regulation of cellular response to insulin stimulus ESRRA, NR1H4, PTPN1, SRC 2.19178
[BP] GO:2000113 None AR, AURKB, ESR1, ESR2, ESRRA, FABP4, HSPA1A, MMP12, NR1H4, NR3C1, PPARA, RORC, SMAD3, SRC, THRA, THRB 2.18524
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, GPER1, MMP2, MMP9 2.18131
[BP] GO:0003013 None ADRA2A, ADRA2C, EGFR, GPER1, SRC, TEK 2.1774
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.17488
[BP] GO:1903393 None KDR, SMAD3, TEK 2.17488
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PPARA 2.17461
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, GPER1, MMP9, SMAD3, SRC, XDH 2.17174
[BP] GO:0045860 positive regulation of protein kinase activity ADRA2A, ADRA2C, CDC25B, EGFR, FLT3, INSR, MIF, PTPN1, SRC 2.158
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, CYP1A1, CYP1B1, KDR, SRC 2.15341
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, GPER1, IGF1R, INSR, SRC 2.15341
[BP] GO:0035624 None ADRA2A, ADRA2C 2.14682
[BP] GO:0061370 testosterone biosynthetic process CYP19A1, HSD17B3 2.14682
[BP] GO:0060509 None THRA, THRB 2.14682
[BP] GO:0014060 None ADRA2A, ADRA2C 2.14682
[BP] GO:0030263 None GPER1, TOP2A 2.14682
[BP] GO:1900078 None ESRRA, NR1H4, SRC 2.14146
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, HSPA1A, MIF, MMP9, PTPN1, SRC 2.12871
[BP] GO:0035556 intracellular signal transduction ADRA2A, ADRA2C, AKR1B1, AXL, CYP1B1, EGFR, GPER1, IGF1R, INSR, KDR, MET, MIF, NUAK1, PTPN1, SRC, TEK 2.1058
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.07279
[BP] GO:1901362 None AKR1B1, APEX1, AR, CSNK2A1, CYP19A1, CYP3A4, DAO, ESR1, ESR2, ESRRA, ESRRB, HSD11B1, HSD17B1, HSD17B2, HSD17B3, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, SMAD3, THRA, THRB, TYR 2.05175
[BP] GO:0019538 protein metabolic process ACHE, ALPL, AR, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A 2.04647
[BP] GO:0035265 organ growth AR, CYP19A1, ESR1 2.01404
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.01404
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.01404
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.01404
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9 2.01404
[CC] GO:0005654 None AKR1B1, ALOX5, APEX1, AR, AURKB, CDC25B, CSNK2A1, DUSP3, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, MIF, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, RORC, SMAD3, SRC, THRA, THRB, TOP2A 3.01495
[CC] GO:0043227 membrane-bounded organelle ACHE, ADRA2C, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, AR, AURKB, AXL, CA1, CA2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, GPER1, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SHBG, SMAD3, SRC, THRA, THRB, TOP2A, TYR, XDH 2.66288
[CC] GO:0044428 nuclear part AKR1B1, ALOX5, AOX1, APEX1, AR, AURKB, CA9, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSPA1A, INSR, MIF, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, RORC, SMAD3, SRC, THRA, THRB, TOP2A 2.49188
[CC] GO:0044444 cytoplasmic part ACHE, ADRA2C, AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, AR, AURKB, CA1, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GPER1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, INSR, KDR, MIF, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, SMAD3, SRC, THRA, TOP2A, TYR, XDH 2.49179
[CC] GO:0016323 basolateral plasma membrane ADRA2A, CA2, CA4, CA9, EGFR, TEK 2.35919
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, AR, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, THRA, THRB, TYR, XDH 21.0479
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, THRA, THRB 17.3876
[MF] GO:0005496 steroid binding AR, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSD17B1, NR1H4, NR3C1, NR3C2, PGR, RORC, SHBG 15.0642
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR1H4, PGR, PPARA, RORC, THRA, THRB 14.9277
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR1H4, PGR, PPARA, RORC, THRA, THRB 14.9277
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, TYR, XDH 13.6907
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PPARA, PTPN1, RORC, SMAD3, THRA, THRB 13.6907
[MF] GO:0042562 hormone binding ACHE, AR, EGFR, GPER1, HSD17B1, IGF1R, INSR, NR3C1, SHBG, THRA, THRB 10.4606
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.1809
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DUSP3, EGFR, F10, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK, TOP2A, TYR, XDH 8.98665
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, THRA, THRB, TOP2A, TYR, XDH 8.94038
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APEX1, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, THRA, THRB, TOP2A, TYR, XDH 8.65948
[MF] GO:0008289 lipid binding AR, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, GPER1, HSD17B1, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, SHBG 8.52117
[MF] GO:0038023 signaling receptor activity ADRA2A, ADRA2C, AR, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GPR35, IGF1R, INSR, KDR, MET, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, TEK, THRA, THRB 8.06762
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.41876
[MF] GO:0004872 receptor activity ADRA2A, ADRA2C, AR, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GPR35, IGF1R, INSR, KDR, MET, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, TEK, THRA, THRB 7.07761
[MF] GO:0004871 signal transducer activity ADRA2A, ADRA2C, AR, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GPR35, IGF1R, INSR, KDR, MET, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, SMAD3, TEK, THRA, THRB 6.96672
[MF] GO:0060089 molecular transducer activity ADRA2A, ADRA2C, AR, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GPR35, IGF1R, INSR, KDR, MET, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, TEK, THRA, THRB 6.86159
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.86159
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.71029
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, HSD11B1, HSD17B1, HSD17B2, HSD17B3, TYR, XDH 6.38438
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.3549
[MF] GO:0044877 macromolecular complex binding ACHE, ADRA2A, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, THRA 5.34393
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.30926
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.2395
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 5.18629
[MF] GO:0032403 protein complex binding ACHE, ADRA2A, APEX1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, THRA 5.14936
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.07766
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, XDH 5.05115
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 4.55591
[MF] GO:0097159 organic cyclic compound binding ADRA2A, ADRA2C, AOX1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SHBG, SMAD3, SRC, TEK, THRA, THRB, TOP2A, XDH 4.5235
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK, TOP2A 4.44607
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2, GPER1 4.12627
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 3.99547
[MF] GO:0019899 enzyme binding ADRA2A, AR, AURKB, CDC25B, CYP1A1, CYP1A2, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRB, HSPA1A, MET, MIF, NR3C1, PGR, PPARA, PTPN1, SMAD3, SRC, TEK, THRB, TOP2A 3.95428
[MF] GO:0000981 None AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, THRA, THRB 3.94408
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.92078
[MF] GO:0043565 None APEX1, AR, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, SMAD3, THRA, THRB 3.73601
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.70943
[MF] GO:0004887 None NR1H4, THRA, THRB 3.66615
[MF] GO:0003690 None APEX1, AR, EGFR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, THRA 3.59356
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2, HSD17B3 3.46952
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD17B1, HSD17B2, HSD17B3 3.3599
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.35284
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.35284
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2, HSD17B3 3.23693
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, ADRA2C, AOX1, CSNK2A1, EGFR, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MIF, MMP9, PGR, SMAD3, TOP2A, TYR, XDH 3.1902
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.1902
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.096
[MF] GO:1901363 heterocyclic compound binding AOX1, APEX1, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR1H4, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, THRA, THRB, TOP2A, XDH 2.99173
[MF] GO:0008134 transcription factor binding APEX1, AR, ESR1, ESRRB, FLT3, NR1H4, PIM1, PPARA, SMAD3, SRC, THRA 2.97087
[MF] GO:0000976 None AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, THRA 2.95696
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, HSD17B1, SRC, XDH 2.95303
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 2.94042
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.93644
[MF] GO:0044212 None AR, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, THRA 2.93206
[MF] GO:0001067 None AR, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, THRA 2.93014
[MF] GO:0000978 None AR, ESR1, ESR2, ESRRA, NR3C1, PGR, PPARA, RORC, SMAD3 2.86657
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.85633
[MF] GO:1990837 None AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3, THRA 2.78258
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.75994
[MF] GO:0001012 None AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3 2.75994
[MF] GO:0000977 None AR, ESR1, ESR2, ESRRA, ESRRB, NR1H4, NR3C1, PGR, PPARA, RORC, SMAD3 2.75994
[MF] GO:0000987 None AR, ESR1, ESR2, ESRRA, NR3C1, PGR, PPARA, RORC, SMAD3 2.73382
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 2.70307
[MF] GO:0019900 None ADRA2A, AURKB, CDC25B, DUSP3, EGFR, ESR1, NR3C1, PTPN1, SMAD3, SRC, TOP2A 2.60651
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.55302
[MF] GO:0004938 None ADRA2A, ADRA2C 2.55302
[MF] GO:0005102 receptor binding ADRA2A, ADRA2C, AR, DAO, EGFR, ESR1, ESR2, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, NR1H4, PTPN1, SMAD3, SRC 2.49179
[MF] GO:0003700 None AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, SMAD3, THRA, THRB 2.45864
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.45864
[MF] GO:0019901 None ADRA2A, CDC25B, DUSP3, EGFR, ESR1, NR3C1, PTPN1, SMAD3, SRC, TOP2A 2.42643
[MF] GO:0036094 small molecule binding AOX1, AURKB, AXL, CSNK2A1, DAO, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NR1H4, NUAK1, PIM1, SRC, TEK, TOP2A, XDH 2.42509
[MF] GO:0001077 None AR, ESR1, ESRRA, NR1H4, NR3C1, PGR, PPARA 2.34199
[MF] GO:0140110 None APEX1, AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSPA1A, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, SMAD3, THRA, THRB 2.3181
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.3181
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.3181
[MF] GO:0005497 None AR, SHBG 2.3181
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.3181
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.27892
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.26833
[MF] GO:0003682 None APEX1, AR, EGFR, ESR1, GPER1, SMAD3, THRA, THRB, TOP2A 2.225
[MF] GO:0043168 anion binding AOX1, AURKB, AXL, CSNK2A1, DAO, EGFR, F10, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NR1H4, NUAK1, PIM1, SRC, TEK, TOP2A, XDH 2.17174
[MF] GO:0000982 None AR, ESR1, ESRRA, NR1H4, NR3C1, PGR, PPARA, RORC 2.17174
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.15806
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.14682
[MF] GO:0043559 insulin binding IGF1R, INSR 2.14682
[MF] GO:0001228 None AR, ESR1, ESRRA, ESRRB, NR1H4, NR3C1, PGR, PPARA 2.1124
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.05221
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK 2.01868


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 9.3275
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP3A4, CYP19A1 10.3506
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.7698
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.0344
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, GPER1, MMP9, ESR1, EGFR, ESR2, HSPA1A 7.1074
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 4.8242
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.0507
Metabolic pathways_Homo sapiens_hsa01100 HSD17B3, AKR1B1, TYR, CYP3A4, CYP19A1, HSD11B1, FUT7, DAO, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 4.5299
Pathways in cancer_Homo sapiens_hsa05200 AR, SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R 3.8274
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 3.8274
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.9642
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.3536
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.8274
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.8274
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 2.8523
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 3.0594
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.9859
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 THRB, THRA, GPR35, NR3C1, ADRA2C, ADRA2A 2.4362
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 2.3191
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.4359
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.2806
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, TEK, MET, EGFR, IGF1R 2.0833
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 THRB, THRA, SRC, ESR1 2.2723
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.0975
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF, TYR 2.6842
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.066
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.0245
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.0213
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.0104
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.0063
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1, CYP3A4 2.0178
Prostate cancer_Homo sapiens_hsa05215 AR, EGFR, IGF1R 1.7807
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.7807
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.7685
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1 1.6938
Bile secretion_Homo sapiens_hsa04976 CA2, NR1H4, CYP3A4 2.0104
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PGR, CDC25B, IGF1R 1.7126
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.6165
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.3847
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.5027
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.3482
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.3482
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.3628
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 INSR, ADRA2C, ADRA2A 1.2524
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.0481
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.0078
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.7794
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.8589
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.8339
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.7875
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8589
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.8339
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.7794
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.0351
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR 1.3189
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2734
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.046
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7794
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.7794
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1204
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.2524
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.7744
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.7557
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3127
Peroxisome_Homo sapiens_hsa04146 DAO, XDH 1.0783
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.7423
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.7423
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.2473
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.2125
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.6148
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2926
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.5901
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2732
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3062
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3001
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2944
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.2996
cAMP signaling pathway_Homo sapiens_hsa04024 PPARA 0.2788
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.2524
Tuberculosis_Homo sapiens_hsa05152 SRC 0.2998
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3001
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2943
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3346
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3752
Platelet activation_Homo sapiens_hsa04611 SRC 0.4004
Axon guidance_Homo sapiens_hsa04360 MET 0.3901
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4269
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4269
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4496
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5 0.4269
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4427
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4496
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4498
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4496
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4537
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4536
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4577
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4704
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4704
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4799
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR, NR3C2 1.5566
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.4375
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4701
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5168
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.4989
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5157
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5047
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5289
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5473
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7165
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5674
Shigellosis_Homo sapiens_hsa05131 SRC 0.549
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.5632
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.5901
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.5632
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5901
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.7342
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6061
Malaria_Homo sapiens_hsa05144 MET 0.6162
Arginine and proline metabolism_Homo sapiens_hsa00330 DAO 0.6148
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6198
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6198
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6142
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6198
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6938
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8851
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 DAO 0.6788
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7233
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6788
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7794
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.753
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7423
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7647
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7794
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.756
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7794
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.9062
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9817
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.9686
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2655


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)