TCM Prescription: Dan Ning Tablet



Prescription Description
Prescription IDTCMF823
Pinyin NameDan Ning Pian 
Chinese Name胆宁片
English NameDan Ning Tablet
Function Description胁痛
IndicationsHypochondrium pain disorder, Cholecystitis
Disease ICD-11 Category SA00 [Hypochondrium pain disorder (TM1), 胁痛 (TM1) ];
DC12 [Cholecystitis, 胆囊炎 ];
Human Tissues Associated with IndicationLiver, Gallbladder
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH921 Polygonum cuspidatum 虎杖 TCMH921 ITSAI2369-14
TCMH1695 Pericarpium citri reticulatae viride 青皮 TCMH1695
TCMH90 Imperata cylindrica 白茅根 TCMH90 ITSAP888-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT132 BCHE Butyrylcholinesterase Hydrolase P06276
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1297 Punta Toro virus
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.6024
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.6024
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCHE, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, KDR, MAOA, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, SRC, TNKS, TNKS2, XDH 13.5497
[BP] GO:0033993 response to lipid ALPL, AR, AXL, BCHE, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, PTGES, PTGS2, RELA, RORC, SRC, TYR 13.2561
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AR, AXL, BCHE, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, MMP2, MMP9, PIK3CA, PTGES, PTGS2, RELA, RORC, SRC, TYR 12.2353
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCHE, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGES, PTGS2, RELA, RORC, SRC, TYR 11.7043
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, AR, BCHE, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD11B2, HTR1B, HTR5A, PTGES, PTGS2, RELA, RORC, SRC, TYR 11.1943
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCHE, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, KDR, MMP2, PIK3CA, PTGES, PTGS2, RELA, RORC, SRC, TYR 10.5485
[BP] GO:0010647 positive regulation of cell communication AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 10.3615
[BP] GO:0023056 positive regulation of signaling AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 10.3338
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, ALOX15, APP, AR, AXL, BCL2, CYP1B1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 9.60556
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MET, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2 9.41611
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCHE, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 9.00065
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, APP, AR, BCHE, BCL2, CDC25B, CSNK2A1, CYP1B1, ESR1, F3, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MMP2, MMP9, PIM1, PTGES, PTGS1, PTGS2, RELA, SRC, XDH 8.88152
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 8.8774
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCHE, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 8.87297
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCHE, BCL2, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, F3, FABP4, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PTGS2, RELA, RORC, SRC, TNKS2, TYR 8.72665
[BP] GO:0050896 response to stimulus ACHE, ADORA3, AKR1B1, ALOX15, ALPL, APP, AR, AURKB, AXL, BCHE, BCL2, CA2, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, KDR, MAP2K1, MAP3K7, MMP2, MMP9, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SRC, TYR 8.14773
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 7.96713
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 7.85538
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGES, PTGS2, RELA, SRC 7.70409
[BP] GO:0042493 response to drug AKR1B1, AXL, BCHE, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KDR, PTGS2, RELA, SRC 7.4897
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, ALOX15, APP, AR, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, F3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, MAP2K1, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 7.48344
[BP] GO:0009725 response to hormone AKR1B1, ALPL, AR, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, PTGS2, RELA, SRC 7.36284
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CACNA1C, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2C 7.15085
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, AR, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, IGF1R, MMP2, PTGS2, RELA, SRC 7.09558
[BP] GO:0007187 None CHRM2, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 7.09558
[BP] GO:0097756 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 7.0801
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 7.06467
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, HSD17B3, HTR2B, HTR2C, PIK3CA, PIM1, PTGES, PTGS1, PTGS2, TYR, XDH 7.04663
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 6.96608
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, ALPL, APP, AR, AURKB, AXL, BCHE, BCL2, CA2, CA9, CACNA1C, CDC25B, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HSD17B3, HTR2A, HTR2B, HTR5A, KDR, MAP2K1, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, RELA, RORC, SRC, TNKS2, TYR 6.81611
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.74607
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2 6.71925
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2B, IGF1R, KDR, MAP2K1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RELA, SRC, XDH 6.71579
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, CACNA1C, CNR1, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 6.67937
[BP] GO:0007165 signal transduction ADORA3, AKR1B1, APP, AR, AXL, BCL2, CA1, CA2, CACNA1C, CHRM2, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PTGES, PTPN1, RELA, RORC, SRC, TNKS, TNKS2 6.56506
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCHE, BCL2, CA2, FLT3, HSD11B2, HTR1B, PTGS2, RELA, SRC 6.37944
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.33244
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, BCL2, CDC25B, CSNK2A1, ESR1, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, MMP2, MMP9, PIM1, PTGS2, RELA 6.31992
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 6.27062
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, F3, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, XDH 6.26031
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAOA, NQO2, PTGS1, PTGS2, TYR, XDH 6.26031
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2 6.19544
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2B, IGF1R, KDR, MAP2K1, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RELA, SRC, XDH 6.1464
[BP] GO:0010941 regulation of cell death AKR1B1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2B, IGF1R, KDR, MAP2K1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RELA, SRC, XDH 6.14102
[BP] GO:0001934 positive regulation of protein phosphorylation ALOX15, APP, AR, BCL2, CDC25B, FLT3, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.90588
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 5.85307
[BP] GO:0048513 animal organ development ACHE, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD11B1, HSD17B2, HSD17B3, KDR, MAP2K1, PIK3CA, RELA, SRC, TYR 5.84066
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2 5.83448
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.75386
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HTR1B, HTR1D, KDR, RELA, SRC 5.73658
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, MMP2, PIK3CA, PTGS2, RELA, RORC, SRC 5.69048
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, APP, AR, BCL2, CDC25B, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.67243
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, APP, AR, BCL2, CDC25B, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.67243
[BP] GO:0042327 positive regulation of phosphorylation ALOX15, APP, AR, BCL2, CDC25B, FLT3, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.66292
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2 5.65041
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, RELA, RORC, SRC 5.62587
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2, HSD17B3 5.53086
[BP] GO:0043410 positive regulation of MAPK cascade ALOX15, APP, AR, FLT3, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC, XDH 5.49733
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, TYR, XDH 5.39862
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC 5.35997
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA3, APP, CA2, CHRM2, CNR1, CNR2, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB, SRC 5.33282
[BP] GO:0007193 None CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 5.30346
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.17331
[BP] GO:0019220 regulation of phosphate metabolic process ALOX15, APP, AR, BCL2, CDC25B, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.09634
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, XDH 5.05962
[BP] GO:0051174 regulation of phosphorus metabolic process ALOX15, APP, AR, BCL2, CDC25B, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.03874
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, RELA, SRC 5.01719
[BP] GO:0051247 positive regulation of protein metabolic process ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 5.00834
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, TYR, XDH 4.88679
[BP] GO:0001932 regulation of protein phosphorylation ALOX15, APP, AR, BCL2, CDC25B, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.86402
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 4.78102
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, HSD17B3, HTR1A, MAOA, TYR 4.75998
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, MAP2K1, MAP3K7, MMP2, MMP9, PIK3CA, PTGS2, PTPN1, RELA, RORC, SRC 4.62447
[BP] GO:0032879 regulation of localization ACHE, ADORA3, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CSNK2A1, CYP19A1, CYP1B1, F3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MET, MMP9, PIK3CB, PTGS2, PTPN1, SRC 4.62125
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIM1, SRC, TNKS 4.59727
[BP] GO:0043408 regulation of MAPK cascade ALOX15, APP, AR, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC, XDH 4.59306
[BP] GO:0048583 regulation of response to stimulus AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, F3, FABP4, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 4.58537
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 4.57446
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, CACNA1C, HTR2A, HTR2B, HTR2C, KDR, SRC 4.5721
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2 4.56776
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, ESR1, FABP3, FABP4, HTR2A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB 4.56776
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, PTGS2, RELA, SRC 4.56214
[BP] GO:0060548 negative regulation of cell death AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, RELA, SRC 4.53063
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, CNR1, CNR2, HTR1B 4.52812
[BP] GO:0031960 response to corticosteroid ALPL, BCHE, BCL2, FLT3, HSD11B2, HTR1B, PTGS2, SRC 4.47586
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2 4.47586
[BP] GO:0003018 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 4.47586
[BP] GO:0031401 positive regulation of protein modification process ALOX15, APP, AR, BCL2, CDC25B, FLT3, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.47465
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 4.47465
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2 4.47455
[BP] GO:0007188 None CHRM2, CNR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 4.46828
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CACNA1C, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD11B1, HSD17B2, HSD17B3, HTR5A, KDR, MAP2K1, MMP9, PIK3CA, PIM1, PTGS2, RELA, RORC, SRC, TYR 4.46345
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, BCHE, CNR2, HTR1B, HTR2A, PTGS2 4.46345
[BP] GO:0050795 None CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 4.46345
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, RELA, SRC 4.45451
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.39712
[BP] GO:0042592 homeostatic process AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, ESR1, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB, SRC 4.389
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, MAP2K1, MET, PIK3CB, PIM1, SRC, TYR 4.36022
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, PTGS2, RELA, SRC 4.36022
[BP] GO:0042325 regulation of phosphorylation ALOX15, APP, AR, BCL2, CDC25B, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.36022
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, BCHE, CNR1, CNR2, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PTGS2, RELA, SRC, TYR 4.36022
[BP] GO:0009966 regulation of signal transduction AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 4.3454
[BP] GO:0099536 None CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 4.33321
[BP] GO:0099537 None CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 4.33321
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, APP, BCHE, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, PTGS2 4.31273
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, APP, BCHE, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, PTGS2 4.31273
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGES, PTGS1, PTGS2 4.27565
[BP] GO:0006805 xenobiotic metabolic process BCHE, CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1, RORC 4.2711
[BP] GO:0032270 positive regulation of cellular protein metabolic process ALOX15, APP, AR, BCL2, CDC25B, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.25843
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.21404
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC 4.2089
[BP] GO:0050790 regulation of catalytic activity ADORA3, APP, AR, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, ESR1, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, XDH 4.2003
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, SRC, TNKS 4.16217
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGES, PTGS2 4.11115
[BP] GO:0001101 response to acid chemical AKR1B1, BCHE, FABP3, HSD17B2, KDR, MMP2, PTGES, PTGS2, RELA, SRC 4.0769
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PTGS2, SRC 4.07559
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.07019
[BP] GO:0097746 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.06287
[BP] GO:0035296 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.06287
[BP] GO:0065007 biological regulation ACHE, ADORA3, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CDC25B, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, XDH 4.04026
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.02124
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, BCHE, CNR1, CNR2, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PTGS2, RELA, SRC, TYR 4.00628
[BP] GO:0033273 response to vitamin ALPL, BCHE, CYP1A1, PTGS2, RELA, TYR 3.91698
[BP] GO:0050880 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 3.89752
[BP] GO:0031399 regulation of protein modification process ALOX15, APP, AR, BCL2, CDC25B, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 3.89752
[BP] GO:0035150 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 3.87857
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, RELA, SRC 3.86575
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCHE, BCL2, CNR1, CYP1A1, HSD11B2, PTGS2, RELA, SRC, TYR 3.84861
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, AKR1B1, APP, AR, AURKB, AXL, BCHE, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, FABP3, FABP4, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MET, MMP9, PIK3CA, PIM1, PTGES, PTGS2, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, XDH 3.84861
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, ESR1, HSD11B2, HSD17B2, HSD17B3, MAP2K1, MMP2, MMP9, PTGS2, SRC 3.84572
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, SRC 3.82926
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, XDH 3.82437
[BP] GO:0048608 reproductive structure development AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSD17B3, MAP2K1, SRC 3.80657
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, AR, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, RORC, SRC 3.79856
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, PTPN1, SRC 3.76114
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CYP1B1, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, RELA, RORC, SRC 3.74709
[BP] GO:0007154 None AR, AXL, BCL2, CACNA1C, CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PTGS2 3.74709
[BP] GO:0003013 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 3.7241
[BP] GO:0032845 None BCL2, HTR2A, HTR2B, HTR2C, SRC, TNKS, TNKS2 3.68909
[BP] GO:0019216 regulation of lipid metabolic process CNR1, CYP1A1, FABP3, FLT3, HTR2A, HTR2B, HTR2C, PTGS2, RORC, SRC 3.68615
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.6078
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.56574
[BP] GO:0007268 None CHRM2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.55981
[BP] GO:0098916 None CHRM2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.55981
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PTGES, PTGS1, PTGS2 3.51371
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS 3.50757
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, ESR1, IGF1R, KDR, MAP2K1, MET, MMP1, MMP9, SRC, TNKS, TNKS2 3.48707
[BP] GO:0044093 positive regulation of molecular function APP, AR, AURKB, BCL2, CDC25B, ESR1, F3, FLT3, HTR2A, HTR2B, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTPN1, RELA, SRC, TNKS, XDH 3.4678
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, PIK3CB, PTGS2, TNKS, TNKS2 3.4405
[BP] GO:0007568 aging AURKB, BCL2, CNR1, CYP1A1, HTR2A, MAP2K1, PTGS2, RELA 3.37495
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, ESR1, HSD17B2, HSD17B3, MAP2K1, PTGS2, SRC 3.33689
[BP] GO:0031325 positive regulation of cellular metabolic process ALOX15, APP, AR, AURKB, BCL2, CDC25B, ESR1, F3, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, XDH 3.32462
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.32297
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.32297
[BP] GO:0009893 positive regulation of metabolic process ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, F3, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, XDH 3.3169
[BP] GO:0010604 positive regulation of macromolecule metabolic process ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, XDH 3.3169
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, RELA, SRC 3.31665
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, RELA, SRC 3.31665
[BP] GO:0031667 response to nutrient levels ALPL, BCHE, BCL2, CNR1, CYP1A1, HSD11B2, PTGS2, RELA, SRC, TYR 3.31417
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, PTGES, PTGS1, PTGS2 3.27129
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, MAP2K1, PIK3CA, RELA, TYR 3.25268
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCHE, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, FABP3, FABP4, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MET, MMP9, PIK3CA, PIM1, PTGES, PTGS2, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, XDH 3.25268
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 3.24228
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.24228
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 3.22072
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, RELA, SRC 3.21389
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, MAP3K7, PIM1, RELA, RORC, SRC 3.19955
[BP] GO:0065009 regulation of molecular function ADORA3, APP, AR, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RELA, SRC, TNKS, XDH 3.18722
[BP] GO:0003008 None AKR1B1, APP, BCHE, BCL2, CNR1, CNR2, CYP1B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA, PTGS2, SRC, TYR 3.18075
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, F3, HTR2A, HTR2B, KDR, MAP2K1, MAP3K7, MET, MMP9, PIM1, PTGS2, RELA, SRC 3.16883
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.14935
[BP] GO:0006950 response to stress ACHE, ADORA3, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HTR1A, HTR2C, MAP2K1, MAP3K7, MMP2, MMP9, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2, PTPN1, RELA, SRC 3.13418
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, BCHE, CSNK2A1, HTR1A, MAOA 3.10282
[BP] GO:0051049 regulation of transport ACHE, ALOX15, APP, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CYP19A1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MAP2K1, MMP9, PIK3CB, PTGS2, PTPN1, SRC 3.10282
[BP] GO:0043405 regulation of MAP kinase activity FLT3, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC 3.09939
[BP] GO:0009628 response to abiotic stimulus AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, HSD11B2, HTR1B, HTR2A, HTR2B, MMP2, PTGS2, RELA, SRC, TYR 3.08272
[BP] GO:0006954 inflammatory response ADORA3, ALOX15, AXL, CNR2, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2, RELA 3.08197
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.05161
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 3.03536
[BP] GO:0019371 None PTGES, PTGS1, PTGS2 3.03536
[BP] GO:0051338 regulation of transferase activity APP, AURKB, CDC25B, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC, TNKS 3.03445
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.03024
[BP] GO:0043406 positive regulation of MAP kinase activity FLT3, HTR2A, HTR2B, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC 3.02618
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.02122
[BP] GO:0007584 response to nutrient ALPL, BCHE, CNR1, CYP1A1, PTGS2, RELA, TYR 2.96386
[BP] GO:0051239 regulation of multicellular organismal process ADORA3, APP, AR, AXL, BCL2, CA2, CACNA1C, CHRM2, CNR1, CYP1B1, ESR1, F3, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIM1, PTGS2, RELA, SRC, TNKS2, XDH 2.9465
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, ESR1, FABP3, HTR2A, HTR2B, HTR2C, PIK3CB 2.93613
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 2.92952
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.9294
[BP] GO:0045859 regulation of protein kinase activity APP, CDC25B, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 2.92148
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 2.91109
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AR, AURKB, AXL, BCHE, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, ESR1, F3, FLT3, FUT7, HTR1A, HTR2B, HTR2C, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, TYR, XDH 2.89761
[BP] GO:0018958 None AKR1B1, BCL2, HTR1A, MAOA, TYR 2.88316
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.86967
[BP] GO:0007208 None HTR2A, HTR2C 2.86967
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BCHE, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, TYR, XDH 2.86037
[BP] GO:0051347 positive regulation of transferase activity AURKB, CDC25B, FLT3, HTR2A, HTR2B, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC, TNKS 2.86037
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, HTR1B, KDR, PTGS2, RELA, SRC 2.85593
[BP] GO:1901570 None ALOX15, ALOX5, PTGES, PTGS1, PTGS2 2.85012
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.85012
[BP] GO:0001516 None PTGES, PTGS1, PTGS2 2.85012
[BP] GO:0046457 None PTGES, PTGS1, PTGS2 2.85012
[BP] GO:0051384 response to glucocorticoid ALPL, BCHE, BCL2, FLT3, HSD11B2, PTGS2 2.7937
[BP] GO:0023052 None AR, CACNA1C, CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.793
[BP] GO:0043271 negative regulation of ion transport BCL2, CNR1, HTR1B, HTR2A, MMP9, PTGS2 2.7634
[BP] GO:0051896 regulation of protein kinase B signaling AXL, F3, MET, PIK3CA, PIK3CB, SRC, XDH 2.7634
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, MMP9, PTGS2, PTPN1, RELA, SRC 2.7634
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.75813
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PTPN1, RELA, SRC 2.70037
[BP] GO:0007200 None CHRM2, ESR1, HTR2A, HTR2B, HTR2C 2.69084
[BP] GO:0042133 neurotransmitter metabolic process ACHE, BCHE, CYP1B1, HTR1A, MAOA 2.66839
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.65421
[BP] GO:0043269 regulation of ion transport APP, BCL2, CA2, CA7, CACNA1C, CNR1, HTR1A, HTR1B, HTR2A, MMP9, PTGS2 2.64745
[BP] GO:0043549 regulation of kinase activity APP, CDC25B, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 2.63985
[BP] GO:0051094 positive regulation of developmental process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, F3, HTR2A, HTR2C, KDR, MAP2K1, PIM1, PTGS2, RELA, SRC 2.60003
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F3, MET, PIK3CA, PIK3CB, SRC 2.60003
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.59565
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.59565
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.59565
[BP] GO:0006952 defense response ADORA3, ALOX15, APP, AXL, BCL2, CNR2, HTR1A, HTR2C, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2, RELA, SRC 2.57327
[BP] GO:0032268 regulation of cellular protein metabolic process ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, ESR1, F3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 2.55986
[BP] GO:0043085 positive regulation of catalytic activity APP, AURKB, BCL2, CDC25B, ESR1, F3, FLT3, HTR2A, HTR2B, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC, TNKS, XDH 2.55986
[BP] GO:0045860 positive regulation of protein kinase activity CDC25B, FLT3, HTR2A, HTR2B, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 2.55986
[BP] GO:0007267 None AR, CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.55302
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, IGF1R, MET, MMP9, PTGS2, PTPN1, RELA, SRC, XDH 2.54155
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.53728
[BP] GO:0010648 negative regulation of cell communication ACHE, AR, BCHE, BCL2, CNR2, ESR1, HTR1B, HTR2A, IGF1R, MET, MMP9, PTGS2, PTPN1, RELA, SRC, XDH 2.5333
[BP] GO:0006939 None HTR1D, HTR2A, HTR2B, HTR7 2.5292
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.5292
[BP] GO:0023057 negative regulation of signaling ACHE, AR, BCHE, BCL2, CNR2, ESR1, HTR1B, HTR2A, IGF1R, MET, MMP9, PTGS2, PTPN1, RELA, SRC, XDH 2.52148
[BP] GO:0009892 negative regulation of metabolic process APP, AR, AURKB, BCL2, CNR1, CNR2, CSNK2A1, ESR1, FABP4, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MAP2K1, MET, MMP9, PIK3CA, PTGS2, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, XDH 2.5157
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.46912
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.46912
[BP] GO:0040012 regulation of locomotion ADORA3, APP, BCL2, CYP19A1, CYP1B1, F3, HTR1D, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.46431
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, MAP2K1, MET, MMP1, MMP9, PIK3CA, PIK3CB, SRC 2.46153
[BP] GO:0051270 regulation of cellular component movement ADORA3, APP, BCL2, CACNA1C, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.45224
[BP] GO:0080134 regulation of response to stress APP, CNR1, CNR2, CYP19A1, ESR1, F3, FABP4, IGF1R, MAP2K1, MAP3K7, MET, MMP2, PTGS2, PTPN1, RELA, SRC, XDH 2.43262
[BP] GO:0030334 regulation of cell migration ADORA3, APP, BCL2, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.42525
[BP] GO:0009987 cellular process ACHE, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CACNA1C, CDC25B, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, TYR, XDH 2.42475
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, CACNA1C, ESR1, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 2.418
[BP] GO:0007610 None APP, BCHE, BCL2, CNR1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, PTGS2 2.41329
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.40237
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.38445
[BP] GO:0044283 None AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, HSD17B3, PTGES, PTGS1, PTGS2 2.36903
[BP] GO:0033674 positive regulation of kinase activity CDC25B, FLT3, HTR2A, HTR2B, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 2.36555
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.3518
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.3518
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, MAP2K1, MMP1, MMP9, PIK3CA, PIK3CB, SRC 2.3518
[BP] GO:0050794 regulation of cellular process ACHE, ADORA3, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCHE, BCL2, CA1, CA2, CA7, CA9, CACNA1C, CDC25B, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, XDH 2.30145
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, HSD11B2, IGF1R, PTGS2, RELA, SRC 2.29477
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.28383
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.28383
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity FLT3, HTR2A, HTR2B, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC 2.28261
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, RELA, SRC 2.28261
[BP] GO:0007166 cell surface receptor signaling pathway ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, F3, FLT3, IGF1R, KDR, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, RELA, SRC, TNKS, TNKS2 2.27376
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, AR, ESR1, FLT3, HTR1B, IGF1R, MMP2, PTGS2, RELA, SRC 2.26826
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, PTGS2, RELA, SRC 2.26513
[BP] GO:0030003 cellular cation homeostasis APP, BCL2, CA2, CA7, CACNA1C, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.26296
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.25128
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9 2.23207
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.22916
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic CNR1, HTR1B, HTR2A, PTGS2 2.22916
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.21957
[BP] GO:0070213 None TNKS, TNKS2 2.21957
[BP] GO:0038171 None CNR1, CNR2 2.21957
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.21957
[BP] GO:0014827 None HTR1D, HTR2B 2.21957
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.20957
[BP] GO:2000145 regulation of cell motility ADORA3, APP, BCL2, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.20649
[BP] GO:0006873 cellular ion homeostasis APP, BCL2, CA2, CA7, CACNA1C, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.19246
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.1894
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.1894
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, RELA 2.18778
[BP] GO:0008285 negative regulation of cell proliferation ADORA3, APP, AR, BCHE, BCL2, CYP1B1, FABP3, MAP2K1, PTGES, PTGS2, XDH 2.18184
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.18082
[BP] GO:0090066 None ALOX15, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 2.16208
[BP] GO:0009605 response to external stimulus ALPL, AXL, BCHE, BCL2, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, HSD11B2, HTR2A, PTGES, PTGS2, RELA, SRC, TYR 2.16174
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, MMP1, MMP9, PIK3CA, PIK3CB, SRC 2.15863
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.14142
[BP] GO:0034097 response to cytokine ALOX15, AXL, BCL2, FABP4, FLT3, PTGES, PTGS2, RELA, SRC 2.13859
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, RELA 2.13795
[BP] GO:0032787 None ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PTGES, PTGS1, PTGS2 2.13421
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, PTGS2, RELA, SRC 2.12595
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.12112
[BP] GO:0060402 None CACNA1C, HTR2A, HTR2B, HTR2C 2.12112
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, MMP9, RELA, SRC 2.1192
[BP] GO:0002009 morphogenesis of an epithelium AR, BCL2, CA2, CA9, ESR1, MET, SRC 2.09568
[BP] GO:0006874 cellular calcium ion homeostasis APP, BCL2, CACNA1C, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.08229
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.08229
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, TYR, XDH 2.08229
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, HTR7, RORC, SRC 2.08154
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.06791
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, PIK3CA, TNKS2 2.05693
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.05693
[BP] GO:0006693 None PTGES, PTGS1, PTGS2 2.05693
[BP] GO:0006692 None PTGES, PTGS1, PTGS2 2.05693
[BP] GO:0051246 regulation of protein metabolic process ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, ESR1, F3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 2.04586
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, MAP3K7, PIM1, RELA 2.04163
[BP] GO:0061370 testosterone biosynthetic process CYP19A1, HSD17B3 2.04163
[BP] GO:0010641 None F3, SRC 2.04163
[BP] GO:0071502 None HTR1B, HTR2B 2.04163
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 2.03257
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HSD17B3 2.01752
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.01752
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, SRC 2.01348
[BP] GO:0055074 calcium ion homeostasis APP, BCL2, CACNA1C, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.0126
[BP] GO:0071900 regulation of protein serine/threonine kinase activity FLT3, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC 2.00793
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SRC, XDH 2.00658
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, HTR1B, IGF1R, MMP2, PTGS2, RELA, SRC 2.00213
[CC] GO:0016020 membrane ACHE, ADORA3, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCHE, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR 8.46101
[CC] GO:0005886 plasma membrane ACHE, ADORA3, ALOX15, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM2, CNR1, CNR2, CSNK2A1, ESR1, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SRC 6.26712
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, APP, AXL, CA4, CHRM2, CNR1, CNR2, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 5.69048
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, BCHE, PTGES 5.39862
[CC] GO:0044425 membrane part ACHE, ADORA3, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM2, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MET, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2, PTPN1, SRC, TYR 5.33282
[CC] GO:0005887 integral component of plasma membrane ADORA3, APP, AXL, CHRM2, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 4.74717
[CC] GO:0044459 plasma membrane part ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, CACNA1C, CHRM2, CNR1, CNR2, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTGS2, SRC 4.53063
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AR, AURKB, BCHE, BCL2, CA1, CA2, CA4, CA7, CACNA1C, CDC25B, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR2A, HTR4, HTR5A, KDR, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, TYR, XDH 2.64745
[CC] GO:0044432 endoplasmic reticulum part APP, BCHE, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, PTGS1, PTGS2, PTPN1 2.51227
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.6024
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.6024
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.5076
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.5076
[MF] GO:0099528 None CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.2937
[MF] GO:0008227 None CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 13.9604
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BCHE, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, TYR, XDH 12.7339
[MF] GO:0042165 neurotransmitter binding ACHE, BCHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 12.7339
[MF] GO:0070405 ammonium ion binding ACHE, BCHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 11.1173
[MF] GO:0030594 None CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 10.7117
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.1042
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, MMP1, MMP2, MMP9, NQO2, PIM1, PTPN1, RORC, TNKS, TYR, XDH 9.66691
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, APP, AR, AURKB, BCHE, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, MAP3K7, MMP1, MMP2, MMP9, NQO2, PIM1, PTGS1, PTGS2, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 7.9529
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, BCHE, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F3, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 7.54889
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAOA, NQO2, PTGS1, PTGS2, TYR, XDH 7.54889
[MF] GO:0038023 signaling receptor activity ADORA3, AR, AXL, CHRM2, CNR1, CNR2, ESR1, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, RORC 6.81611
[MF] GO:0004871 signal transducer activity ADORA3, AR, AXL, CHRM2, CNR1, CNR2, ESR1, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MAP2K1, MAP3K7, MET, RORC 6.40144
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.1464
[MF] GO:0004872 receptor activity ADORA3, AR, AXL, CHRM2, CNR1, CNR2, ESR1, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, RORC 5.90588
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC 5.73658
[MF] GO:0060089 molecular transducer activity ADORA3, AR, AXL, CHRM2, CNR1, CNR2, ESR1, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, RORC 5.69048
[MF] GO:0099600 transmembrane receptor activity ADORA3, AXL, CHRM2, CNR1, CNR2, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 5.51847
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, AXL, CHRM2, CNR1, CNR2, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 5.51847
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.33282
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.84777
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, XDH 4.83822
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.70363
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, NQO2, PTGES, PTGS1, PTGS2, SRC, XDH 4.19296
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.16217
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, CA9, ESR1, MMP1, MMP2, MMP9, NQO2, PTPN1, RORC, TNKS 4.06287
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC 3.98034
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NQO2, SHBG 3.84533
[MF] GO:0005496 steroid binding AR, ESR1, HSD11B2, HSD17B1, RORC, SHBG 3.82284
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC 3.79856
[MF] GO:0004930 None ADORA3, CHRM2, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 3.73714
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.63893
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TYR 3.49669
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.4405
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.41633
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.30051
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.11546
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.08036
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 3.03536
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIM1, SRC 3.0302
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, SRC 2.94352
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.86967
[MF] GO:0003990 acetylcholinesterase activity ACHE, BCHE 2.86967
[MF] GO:0003845 None HSD11B1, HSD11B2 2.86967
[MF] GO:0071886 None HTR2A, HTR2C 2.86967
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.86825
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, MAP3K7, MMP1, MMP2, MMP9, NQO2, PIM1, PTGS1, PTGS2, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 2.7937
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.61555
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, SRC 2.60078
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.53728
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.46912
[MF] GO:0004949 None CNR1, CNR2 2.46912
[MF] GO:0004104 cholinesterase activity ACHE, BCHE 2.46912
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.30925
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, ESR1, F3, FABP3, FABP4, HSD11B2, HSD17B1, RORC, SHBG 2.29866
[MF] GO:0005497 None AR, SHBG 2.21957
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, PTGS2 2.05693
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, PTGS2 2.01752
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, SRC 2.00855


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAP2K1, HTR1E, MAOA, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, CACNA1C, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, ALOX5 23.6492
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, HTR1E, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, HTR5A, HTR4, HTR6, HTR7, CNR2, CNR1, ADORA3 10.9842
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HTR6, MAP2K1, PIK3CA, HTR1E, HTR1D, HTR1A, HTR1B, CACNA1C, PIK3CB, HTR4, RELA 9.3428
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP19A1 10.3405
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.3428
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.9842
Pathways in cancer_Homo sapiens_hsa05200 MAP2K1, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, RELA, IGF1R, AR, PIK3CA, BCL2, MET 7.0535
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 6.9108
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6, HTR7, HTR2B, HTR2C, CACNA1C, HTR2A, HTR5A, HTR4 6.2333
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, PIK3CA, BCL2, PIK3CB, RELA, IGF1R 6.0537
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3, RELA 5.8074
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, PIK3CA, FLT3, PIM1, PIK3CB, RELA 5.8821
Metabolic pathways_Homo sapiens_hsa01100 MAOA, ALOX15, HSD17B3, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, PTGES 5.7373
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1 5.8116
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, MAP2K1, PIK3CA, BCL2, CACNA1C, PIK3CB 5.6207
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, PIK3CA, SRC, KDR, PIK3CB, PTGS2 5.8074
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, PIK3CA, PIK3CB, PTGS2, MMP9, MAP3K7, RELA 5.6212
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, PIK3CA, SRC, PIK3CB, ESR1, RELA 5.4819
Focal adhesion_Homo sapiens_hsa04510 MAP2K1, PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 5.0434
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, PIK3CA, SRC, CNR1, KDR, PIK3CB, MET, IGF1R 4.9408
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, PIK3CA, SRC, BCL2, PIK3CB, MMP9, RELA 4.9408
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MAP3K7, MET, IGF1R 5.434
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 4.8303
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, HTR7, PIK3CA, KDR, PIK3CB, MET, RELA, IGF1R 4.7737
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, HTR2B, HTR2C, PIK3CB, HTR2A 4.8303
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, MAP2K1, PIK3CA, KDR, BCL2, PIK3CB, MET, RELA, IGF1R 4.4598
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, PIK3CA, BCL2, PIK3CB, RELA, IGF1R 4.7533
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9 5.3627
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, MAP3K7, RELA 4.4598
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, PIK3CB, PTGS2, PTGS1 4.7889
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, PIK3CA, ADORA3, BCL2, PIK3CB, RELA 4.4397
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, PIK3CA, FLT3, PIK3CB, MET 4.4626
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, PTGS2, PTGES, PTGS1 4.6151
Melanoma_Homo sapiens_hsa05218 MAP2K1, PIK3CA, PIK3CB, MET, IGF1R 4.3923
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, PIK3CA, SRC, CACNA1C, PIK3CB, PTGS2 3.8539
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B, CACNA1C 4.0964
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, PIK3CA, PIK3CB, CDC25B, IGF1R 3.8019
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2, RELA 4.0329
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2 4.0979
Gap junction_Homo sapiens_hsa04540 MAP2K1, SRC, HTR2B, HTR2C, HTR2A 3.9957
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.6586
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.6882
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2, MAP3K7, RELA 3.8904
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, MAP3K7, RELA 3.3573
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 MAP2K1, PIK3CA, SRC, PIK3CB, ESR1 3.4468
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, PIK3CA, BCL2, PIK3CB, RELA 3.4312
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.2886
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, MAP3K7, RELA 3.2583
Apoptosis_Homo sapiens_hsa04210 MAP2K1, PIK3CA, BCL2, PIK3CB, RELA 3.2084
Glioma_Homo sapiens_hsa05214 MAP2K1, PIK3CA, PIK3CB, IGF1R 3.3798
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, PIK3CA, ADORA3, CACNA1C, PIK3CB 2.8914
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1, PIK3CA, BCL2, PIK3CB 3.4415
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, PIK3CA, PIK3CB, RELA 3.3716
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.757
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, PIK3CA, SRC, PIK3CB, RELA 2.6889
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, PIK3CA, PIK3CB, RELA 3.2583
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, PIK3CA, PIK3CB, MET 3.3716
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, MMP2, CACNA1C 2.9205
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, PIK3CA, PIK3CB, RELA 3.2583
ErbB signaling pathway_Homo sapiens_hsa04012 MAP2K1, PIK3CA, SRC, PIK3CB 2.9876
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, RELA 2.6688
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, MAP2K1, PIK3CA, SRC, PIK3CB 2.4777
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, RELA, IGF1R 2.8877
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.5086
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.1622
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, CYP1B1 4.0964
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.5561
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, MAP3K7, IGF1R 2.4946
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, PIK3CA, PIK3CB, IGF1R 2.3945
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.2583
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, PIK3CA, PIK3CB, IGF1R 2.3078
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, MAP2K1, PIK3CA, PIK3CB 2.3359
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, CACNA1C, MAP3K7, RELA, CDC25B 2.2016
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, CACNA1C, PIK3CB 2.2644
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 2.1778
Influenza A_Homo sapiens_hsa05164 MAP2K1, PIK3CA, PIK3CB, RELA 2.03
Purine metabolism_Homo sapiens_hsa00230 XDH 0.306
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3159
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB, RELA 1.8377
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.5262
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4114
Axon guidance_Homo sapiens_hsa04360 MET 0.4058
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.4377
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9504
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, RELA 1.476
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1, PIK3CA, PIK3CB 1.5874
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, PIK3CB, RELA 0.9706
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1, PIK3CA, PIK3CB 1.5219
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, RELA 1.5962
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA 0.7319
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.6784
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.7696
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1, PIK3CA, PIK3CB 1.8887
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1, PIK3CA, PIK3CB 1.9642
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.497
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8854
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4958
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB, RELA 1.8914
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, MAP3K7 0.8732
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.497
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB, RELA 1.8586
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.2996
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5114
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5117
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, CACNA1C, PTGS2 1.8887
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, CACNA1C 0.9266
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2, RELA 1.3383
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.5114
Salmonella infection_Homo sapiens_hsa05132 RELA 0.5174
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.519
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5114
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 0.9706
Peroxisome_Homo sapiens_hsa04146 XDH 0.5251
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.5287
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.5251
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5372
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5352
Melanogenesis_Homo sapiens_hsa04916 MAP2K1, TYR 1.0981
Pertussis_Homo sapiens_hsa05133 RELA 0.549
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5513
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1, PIK3CA, PIK3CB 2.3013
Adipocytokine signaling pathway_Homo sapiens_hsa04920 RELA 0.5637
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.1101
Bile secretion_Homo sapiens_hsa04976 CA2 0.5611
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5513
Leishmaniasis_Homo sapiens_hsa05140 PTGS2, MAP3K7, RELA 2.2295
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.3545
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.1864
Renin secretion_Homo sapiens_hsa04924 CACNA1C 0.595
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.595
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, RELA 2.3013
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1 2.2886
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1, PIK3CA, PIK3CB 2.4984
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1, PIK3CA, PIK3CB 2.5735
Legionellosis_Homo sapiens_hsa05134 RELA 0.6478
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.3451
Long-term potentiation_Homo sapiens_hsa04720 MAP2K1, CACNA1C 1.3886
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.3527
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, CACNA1C 1.3803
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP1A2 1.3605
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6745
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.3971
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.6792
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.4501
Long-term depression_Homo sapiens_hsa04730 MAP2K1, IGF1R 1.4501
Malaria_Homo sapiens_hsa05144 MET 0.6842
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC, RELA 1.3971
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.3971
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, CACNA1C, PIK3CB 2.6688
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6977
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.476
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4558
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7033
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB 2.8948
Cocaine addiction_Homo sapiens_hsa05030 MAOA, RELA 1.5874
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.753
Prion diseases_Homo sapiens_hsa05020 MAP2K1 0.8008
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.6449
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.8681
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8471
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1 0.8877
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9404
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8969
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8573
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, TYR 1.8377
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8914
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8877
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.9642
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8228
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.9266
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1483
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 1.0536
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1249
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.3135


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)