TCM Prescription: Dan Shi Tong Capsule



Prescription Description
Prescription IDTCMF821
Pinyin NameDan Shi Tong Jiao Nang 
Chinese Name胆石通胶囊
English NameDan Shi Tong Capsule
Function Description胁痛, 黄疸
IndicationsHypochondrium pain disorder, Jaundice disorder, Jaundice, Cholecystitis
Disease ICD-11 Category SA00 [Hypochondrium pain disorder (TM1), 胁痛 (TM1) ];
SA01 [Jaundice disorder (TM1), 黄疸 (TM1) ];
ME10.1 [Unspecified jaundice, 未特指的黄疸 ];
DC12 [Cholecystitis, 胆囊炎 ];
Human Tissues Associated with IndicationLiver, Gallbladder
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1632 Taraxacum mongolicum 蒲公英 TCMH1632 ITSAG679-14
TCMH2004 Hedyotis corymbosa 水线草 TCMH2004 CPBOL1316-11
TCMH2494 Artemisia capillaris 茵陈蒿 TCMH2494 ITSAN1371-14
TCMH733 Desmodium styracifolium 广金钱草 TCMH733 ITSAK2600-14
TCMH2228 Rabdosia serra 溪黄草 TCMH2228
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH540 NA 鹅胆粉 TCMH540
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.2571
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.2571
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, KDR, KIT, MET, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PTGS1, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 13.9264
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, KDR, KIT, MMP2, MMP9, PIK3CA, POLB, PPARA, PTGS2, SRC, TERT, TOP1, TYR 13.2813
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, ALPL, APEX1, APP, AXL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, MMP2, MMP9, PIK3CA, POLB, PPARA, PTGS2, SRC, TYR 11.0569
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 10.853
[BP] GO:0010033 response to organic substance AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, KDR, KIT, MMP2, PIK3CA, POLB, PPARA, PTGS2, SRC, TYR 10.0244
[BP] GO:0033993 response to lipid AKR1C3, ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, PTGS2, SRC, TYR 9.50041
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, PTGS2, SRC, TERT 9.02062
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 8.84937
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GLO1, HTR2B, HTR2C, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR, XDH 8.81691
[BP] GO:0014070 response to organic cyclic compound AKR1C3, ALPL, APEX1, APP, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, HTR1B, HTR5A, PTGS2, SRC, TYR 8.58433
[BP] GO:0010647 positive regulation of cell communication AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 8.51969
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F10, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PTGS1, PTGS2, SRC, TERT, TOP1, TOP2A, TYR 8.51773
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KDR, POLB, PTGS2, SRC, TOP1 8.51773
[BP] GO:0023056 positive regulation of signaling AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 8.51717
[BP] GO:0009725 response to hormone AKR1B1, AKR1C3, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, KIT, PPARA, PTGS2, SRC 8.47713
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 8.07031
[BP] GO:0009719 response to endogenous stimulus AKR1B1, AKR1C3, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, IGF1R, KIT, MMP2, PPARA, PTGS2, SRC 7.91142
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F10, FABP4, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC, TNKS2, TOP1, TYR 7.89663
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 7.86606
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 7.81353
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 7.5662
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.5662
[BP] GO:0032502 developmental process ACHE, AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS2, TOP2A, TYR 7.28823
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, F10, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 7.25235
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F10, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 7.00758
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F10, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 6.85427
[BP] GO:0097756 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 6.82887
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 6.81202
[BP] GO:0007187 None CHRM2, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 6.74197
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.70053
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 6.70053
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 6.69221
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, AKR1C3, APP, BCL2, CSNK2A1, CYP1B1, ESR1, ESRRA, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PTGS1, PTGS2, SRC, TERT, XDH 6.61338
[BP] GO:0019371 None AKR1C3, CBR1, PTGS1, PTGS2, TBXAS1 6.61338
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 6.61338
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, SRC 6.61338
[BP] GO:0010941 regulation of cell death AKR1B1, AKR1C3, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HTR2B, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, TERT, TOP2A, XDH 6.61338
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AKR1C3, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HTR2B, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, TERT, TOP2A, XDH 6.60487
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.55928
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESRRA, F10, FABP4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 6.55928
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, KIT, PIK3CA, POLB, PPARA, PTPRS, SRC, TYR 6.55928
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CYP1B1, F10, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MET, PIK3CA, PIK3CB, PTGS2, SRC, XDH 6.55928
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 6.33756
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 6.30191
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 6.27438
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HTR1B, HTR1D, KDR, POLB, SRC 6.21532
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 6.12001
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PPARA, PTGS2, SRC 6.02031
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, AKR1C3, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2C 5.86323
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS1, PTGS2, TBXAS1 5.78317
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AKR1C3, BCL2, CSNK2A1, ESR1, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PTGS2, TERT 5.75612
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.64434
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 5.63728
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.585
[BP] GO:0042592 homeostatic process AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB, POLA1, POLB, SRC, TERT 5.55571
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, KIT, MMP2, MMP9, PIK3CA, PTGS2, SRC, TERT 5.53806
[BP] GO:0010038 response to metal ion AKR1C3, ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9, PTGS2, TERT 5.48017
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 5.45144
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AKR1C3, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, TERT, TOP2A, XDH 5.44074
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, CNR1, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 5.40485
[BP] GO:0048583 regulation of response to stimulus ABCB1, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F10, FABP4, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 5.39087
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA3, AKR1C3, APP, CA2, CHRM2, CNR1, CNR2, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB, SRC 5.31531
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 5.27793
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, SRC 5.21265
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F10, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 5.18951
[BP] GO:0071310 cellular response to organic substance AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, KIT, MMP2, PIK3CA, PTGS2, SRC 5.06749
[BP] GO:0007193 None CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 5.06518
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.04676
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, AKR1B1, AKR1C3, APEX1, APP, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 5.01412
[BP] GO:0019216 regulation of lipid metabolic process AKR1C3, CNR1, CYP1A1, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PPARA, PTGS2, SRC 4.94463
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA3, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1B1, F10, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CB, PPARA, PTGS2, SRC, TERT 4.80703
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HTR2B, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC, TERT 4.65822
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, FLT3, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, POLB, PTGS2, PTPRS, SRC, TNKS, TOP1, XDH 4.60474
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, KIT, MET, PIK3CB, PIM1, POLA1, SRC, TYR 4.60474
[BP] GO:0032787 None AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PPARA, PTGS1, PTGS2, TBXAS1 4.56938
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HTR2B, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PTGS2, SRC, TERT 4.51372
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 4.41375
[BP] GO:0009628 response to abiotic stimulus AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, HSD11B2, HTR1B, HTR2A, HTR2B, KIT, MMP2, POLB, PPARA, PTGS2, SRC, TERT, TYR 4.35291
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, CNR1, CNR2, HTR1B 4.34857
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APEX1, APP, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, SRC 4.31501
[BP] GO:0051716 cellular response to stimulus AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, KIT, MMP2, MMP9, PIK3CA, POLA1, POLB, PTGS2, SRC, TERT, TOP2A 4.31074
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 4.28861
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.26907
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, FLT3, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, POLB, PTGS2, PTPRS, SRC, TNKS, TOP1, XDH 4.26907
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, F10, KIT, MET, PIK3CA, PIK3CB, SRC 4.26907
[BP] GO:0007165 signal transduction ADORA3, AKR1B1, AKR1C3, APP, AXL, BCL2, CA1, CA2, CHRM2, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLB, PPARA, SRC, TNKS, TNKS2 4.25318
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, F10, KIT, MET, PIK3CA, PIK3CB, SRC, XDH 4.25318
[BP] GO:0050795 None CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 4.24707
[BP] GO:0031960 response to corticosteroid AKR1C3, ALPL, BCL2, FLT3, HSD11B2, HTR1B, PTGS2, SRC 4.22373
[BP] GO:0003018 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 4.22373
[BP] GO:0007188 None CHRM2, CNR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 4.20557
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, HTR7, KIT, PPARA, SRC, TOP1, TOP2A 4.17174
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, MMP9, SRC 4.15543
[BP] GO:0048545 response to steroid hormone AKR1C3, ALPL, BCL2, CA2, FLT3, HSD11B2, HTR1B, PTGS2, SRC 4.14269
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 4.09691
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.04943
[BP] GO:0099536 None CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.98601
[BP] GO:0099537 None CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.98601
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CNR1, CYP1A1, HTR2A, POLB, PTGS2, TERT 3.96861
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, APP, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, KIT, PTGS2 3.96861
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, APP, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, KIT, PTGS2 3.96861
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 3.93848
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 3.92429
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AXL, BCL2, CA2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HTR5A, KDR, KIT, MMP9, PIK3CA, PIM1, POLB, PPARA, PTGS2, PTPRS, SRC, TYR 3.91494
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, CNR1, CNR2, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 3.89374
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC 3.89322
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2, TERT 3.864
[BP] GO:0006950 response to stress ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HTR1A, HTR2C, KIT, MMP2, MMP9, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PTGS1, PTGS2, SRC, TERT, TOP2A 3.83033
[BP] GO:0030334 regulation of cell migration ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 3.82023
[BP] GO:0097746 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 3.80402
[BP] GO:0035296 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 3.80402
[BP] GO:0009966 regulation of signal transduction AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, F10, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 3.77487
[BP] GO:0040012 regulation of locomotion ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, F10, HTR1D, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 3.76806
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.76806
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TOP2A, TUBB3, TYR, XDH 3.70254
[BP] GO:0050880 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 3.64029
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, HTR1A, TYR 3.63865
[BP] GO:0035150 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 3.62356
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, KIT, PIM1, SRC 3.54819
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9, TERT 3.53716
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, CNR1, CNR2, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 3.53505
[BP] GO:2000145 regulation of cell motility ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 3.5246
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, FLT3, HTR2B, IGF1R, KDR, KIT, MET, PIK3CA, PIM1, SRC, TNKS, TOP1 3.51874
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, HTR2A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB 3.47438
[BP] GO:0040016 embryonic cleavage PIK3CB, TOP1, TOP2A 3.47438
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.47438
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, ALPL, APEX1, APP, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, SRC 3.45589
[BP] GO:0003013 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 3.4353
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 3.4353
[BP] GO:0032845 None BCL2, HTR2A, HTR2B, HTR2C, SRC, TNKS, TNKS2 3.43298
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 3.40958
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.40953
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, HTR2A, HTR2B, HTR2C, KDR, SRC 3.39795
[BP] GO:0019220 regulation of phosphate metabolic process ALOX15, APP, BCL2, ESRRB, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 3.39381
[BP] GO:0071248 cellular response to metal ion AKR1C3, ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.36569
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, SRC, TERT 3.35847
[BP] GO:0051174 regulation of phosphorus metabolic process ALOX15, APP, BCL2, ESRRB, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 3.34565
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, XDH 3.34565
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 3.34072
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.31124
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.31124
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.31124
[BP] GO:0046686 response to cadmium ion AKR1C3, CYP1A2, KIT, MMP9, TERT 3.31026
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, APP, BCL2, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 3.31026
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, APP, BCL2, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 3.31026
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CNR1, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, KIT, MMP2, MMP9, PTGS2, SRC, TOP2A 3.30841
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 3.30407
[BP] GO:0007154 None AKR1C3, AXL, BCL2, CHRM2, CNR1, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PTGS2 3.30407
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, POLB, PPARA, PTGS2, SRC, TERT 3.28894
[BP] GO:0042327 positive regulation of phosphorylation ALOX15, APP, BCL2, ESRRB, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 3.28408
[BP] GO:0007268 None CHRM2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.28318
[BP] GO:0098916 None CHRM2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.28318
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.22532
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 3.20621
[BP] GO:0003008 None AKR1B1, AKR1C3, APP, BCL2, CNR1, CNR2, CYP1B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, KIT, PIK3CA, PTGS2, SRC, TYR 3.19656
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, PIK3CB, PTGS2, TNKS, TNKS2 3.19109
[BP] GO:0051270 regulation of cellular component movement ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 3.18094
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.18094
[BP] GO:0031325 positive regulation of cellular metabolic process AKR1C3, ALOX15, APP, AURKB, BCL2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.17061
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.16959
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.12483
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, FLT3, HTR2B, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC, TNKS, TOP1 3.09745
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 3.08297
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, CNR2, HTR1B, HTR2A, PTGS2 3.07999
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 3.07999
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.07999
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.04897
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.04897
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, SRC, TNKS 3.04233
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ALOX15, APP, AURKB, BCL2, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.02752
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.02392
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ALOX15, APP, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, MMP9, PIK3CB, PPARA, PTGS2, SRC, TERT 3.01821
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, SRC 3.01127
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 2.98059
[BP] GO:0010863 positive regulation of phospholipase C activity ESR1, HTR2A, HTR2B, KIT 2.93895
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1, GLO1 2.93777
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 2.93076
[BP] GO:0009893 positive regulation of metabolic process AKR1C3, ALOX15, APP, AURKB, BCL2, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.9296
[BP] GO:0001934 positive regulation of protein phosphorylation ALOX15, APP, BCL2, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.9296
[BP] GO:0043410 positive regulation of MAPK cascade ALOX15, APP, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, PIK3CB, SRC, XDH 2.9296
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 2.92182
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.9188
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, KIT, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.90546
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.86514
[BP] GO:0006082 organic acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 2.84002
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 2.83411
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC, TERT 2.82684
[BP] GO:1900274 regulation of phospholipase C activity ESR1, HTR2A, HTR2B, KIT 2.81374
[BP] GO:0009991 response to extracellular stimulus AKR1C3, ALPL, AXL, BCL2, CNR1, CYP1A1, HSD11B2, PTGS2, SRC, TYR 2.81374
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT, TNKS 2.81374
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 2.81374
[BP] GO:0007208 None HTR2A, HTR2C 2.81374
[BP] GO:0016488 None AKR1B10, AKR1C3 2.81374
[BP] GO:0016487 None AKR1B10, AKR1C3 2.81374
[BP] GO:0016107 None AKR1B10, AKR1C3 2.81374
[BP] GO:0009115 None AOX1, XDH 2.81374
[BP] GO:0006714 None AKR1B10, AKR1C3 2.81374
[BP] GO:0006286 base-excision repair, base-free sugar-phosphate removal APEX1, POLB 2.81374
[BP] GO:0006954 inflammatory response ADORA3, ALOX15, AXL, CNR2, KIT, PIK3CA, PIK3CB, POLB, PTGS1, PTGS2 2.8108
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGS1, PTGS2 2.79561
[BP] GO:0042325 regulation of phosphorylation ALOX15, APP, BCL2, ESRRB, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 2.79561
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2, TERT 2.78973
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, HSD11B2, IGF1R, PPARA, PTGS2, SRC 2.7775
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC, TERT 2.77041
[BP] GO:0007610 None APP, BCL2, CNR1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, KIT, PPARA, PTGS2 2.76296
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APEX1, APP, AXL, CYP1B1, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, SRC 2.76296
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, MMP9, SRC 2.76118
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.76111
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.76077
[BP] GO:0048608 reproductive structure development AKR1C3, AXL, BCL2, CYP19A1, ESR1, HSD17B2, KIT, SRC 2.74515
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, TOP2A 2.74273
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, HTR2A, HTR2B, HTR2C, KDR, SRC 2.7262
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, F10, FLT3, IGF1R, KDR, KIT, MET, SRC, TNKS, TOP1, TOP2A 2.72386
[BP] GO:1904705 regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9, TERT 2.72386
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGS2, SRC 2.67502
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.66981
[BP] GO:0010604 positive regulation of macromolecule metabolic process ALOX15, APP, AURKB, BCL2, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.65788
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, HTR1B, KDR, PTGS2, SRC 2.62426
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, KIT, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.60762
[BP] GO:0043271 negative regulation of ion transport BCL2, CNR1, HTR1B, HTR2A, MMP9, PTGS2 2.5835
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.58334
[BP] GO:0044259 multicellular organismal macromolecule metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.56599
[BP] GO:0007200 None CHRM2, ESR1, HTR2A, HTR2B, HTR2C 2.5433
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AKR1C3, APEX1, APP, ESR1, FLT3, HTR1B, IGF1R, KIT, MMP2, PTGS2, SRC 2.5433
[BP] GO:0050999 None CNR1, CNR2, HTR2B, TERT 2.53576
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, KIT, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.53576
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, CNR1, ESR1, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.53222
[BP] GO:0009892 negative regulation of metabolic process AKR1C3, APEX1, APP, AURKB, BCL2, CNR1, CNR2, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 2.52179
[BP] GO:0031324 negative regulation of cellular metabolic process AKR1C3, APEX1, APP, AURKB, BCL2, CNR1, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, HTR1B, HTR1E, HTR2B, IGF1R, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 2.51886
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.51214
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.51214
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.51214
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGS2, SRC 2.50165
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA3, AKR1C3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, XDH 2.49948
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.4349
[BP] GO:0098502 DNA dephosphorylation APEX1, POLB 2.41105
[BP] GO:0046110 None AOX1, XDH 2.41105
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.41105
[BP] GO:0016095 None AKR1B10, AKR1C3 2.41105
[BP] GO:0006939 None HTR1D, HTR2A, HTR2B, HTR7 2.41105
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, ALPL, AXL, BCL2, CYP19A1, ESR1, ESRRB, HSD17B2, KIT, PTGS2, SRC 2.40927
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, MET, MMP12, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, TOP2A 2.38252
[BP] GO:0010518 positive regulation of phospholipase activity ESR1, HTR2A, HTR2B, KIT 2.381
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3 2.37515
[BP] GO:0043408 regulation of MAPK cascade ALOX15, APP, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, PIK3CB, SRC, XDH 2.37124
[BP] GO:0043269 regulation of ion transport ABCB1, APP, BCL2, CA2, CA7, CNR1, HTR1A, HTR1B, HTR2A, MMP9, PTGS2 2.35966
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, FABP3, FABP4, KIT, MET, PIK3CA, PIK3CB 2.35966
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1A1, CYP1A2, ESR1, F10, FLT3, FUT7, GLO1, HTR1A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, POLB, PPARA, PTGS2, PTPRS, SRC, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 2.35733
[BP] GO:0031667 response to nutrient levels AKR1C3, ALPL, BCL2, CNR1, CYP1A1, HSD11B2, PTGS2, SRC, TYR 2.35412
[BP] GO:0051239 regulation of multicellular organismal process ADORA3, APP, AXL, BCL2, CA2, CHRM2, CNR1, CYP1B1, ESR1, ESRRA, ESRRB, HTR2A, HTR2B, HTR2C, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIM1, PTGS2, PTPRS, SRC, TERT, TNKS2, XDH 2.32968
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.31397
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.30337
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.28095
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GLO1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, XDH 2.28088
[BP] GO:0001932 regulation of protein phosphorylation ALOX15, APP, BCL2, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.28088
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, KIT, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TUBB3 2.26883
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.26883
[BP] GO:0007267 None CHRM2, CNR1, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.26646
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, POLB, TYR 2.24599
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.24599
[BP] GO:0046890 None AKR1C3, FABP3, HTR2A, HTR2B, HTR2C, PTGS2 2.24599
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CNR1, CYP1B1, ESRRB, HTR2A, HTR2B, KDR, KIT, MET, MMP12, MMP9, PIM1, PTGS2, SRC, TERT 2.24566
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AKR1C3, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 2.23599
[BP] GO:0032768 None CNR1, CNR2, HTR2B, TERT 2.21826
[BP] GO:0044236 multicellular organism metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.20736
[BP] GO:0006952 defense response ADORA3, ALOX15, APP, AXL, BCL2, CNR2, HTR1A, HTR2C, KIT, PIK3CA, PIK3CB, POLB, PTGS1, PTGS2, SRC 2.20736
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.20736
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.20736
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1 2.19348
[BP] GO:0008406 gonad development AKR1C3, BCL2, CYP19A1, ESR1, KIT 2.1756
[BP] GO:0070213 None TNKS, TNKS2 2.1699
[BP] GO:0006145 None AOX1, XDH 2.1699
[BP] GO:0038171 None CNR1, CNR2 2.1699
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.1699
[BP] GO:0014827 None HTR1D, HTR2B 2.1699
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.15729
[BP] GO:0010648 negative regulation of cell communication ACHE, BCL2, CNR2, ESR1, ESR2, HTR1B, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPRS, SRC, TERT, XDH 2.14883
[BP] GO:0023057 negative regulation of signaling ACHE, BCL2, CNR2, ESR1, ESR2, HTR1B, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPRS, SRC, TERT, XDH 2.13437
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.1254
[BP] GO:0010517 regulation of phospholipase activity ESR1, HTR2A, HTR2B, KIT 2.12316
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic CNR1, HTR1B, HTR2A, PTGS2 2.12316
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, PPARA 2.1112
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.1075
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.1075
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.09937
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.08646
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1 2.08646
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, KIT, MMP9 2.08118
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, AKR1C3, CSNK2A1, HTR1A 2.08
[BP] GO:0080090 regulation of primary metabolic process ADORA3, AKR1C3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.07895
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.07895
[BP] GO:0050900 leukocyte migration CNR2, FUT7, KIT, MMP1, MMP9, PIK3CA, PIK3CB, SRC 2.07895
[BP] GO:0019725 cellular homeostasis APEX1, APP, BCL2, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, POLA1 2.06644
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, ESR1, FABP3, HTR2A, HTR2B, HTR2C, PIK3CB 2.06595
[BP] GO:0050794 regulation of cellular process ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GLO1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.06595
[BP] GO:0032098 None HTR2C, HTR4, PPARA 2.06595
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.06595
[BP] GO:0060193 positive regulation of lipase activity ESR1, HTR2A, HTR2B, KIT 2.05885
[BP] GO:0048869 cellular developmental process ACHE, AKR1C3, ALPL, APP, AXL, BCL2, CBR1, CYP1A1, ESR1, ESRRB, FABP4, FLT3, FUT7, GLO1, HTR2B, KDR, KIT, MET, MMP2, MMP9, PTGS2, PTPRS, SRC, TERT, TOP2A 2.04897
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, SRC 2.04255
[BP] GO:0080134 regulation of response to stress ABCB1, APP, CNR1, CNR2, CYP19A1, ESR1, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PTGS2, PTPRS, SRC, TERT, XDH 2.03809
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA3, AKR1C3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CNR1, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.02926
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.01197
[BP] GO:0016042 lipid catabolic process AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.00994
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.00365
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, APP, AXL, CA4, CHRM2, CNR1, CNR2, F10, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTPRS 5.61993
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA3, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CSNK2A1, ESR1, F10, FLT3, GLO1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPRS, SRC, TERT 4.95002
[CC] GO:0005887 integral component of plasma membrane ADORA3, APP, AXL, CHRM2, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTPRS 4.71989
[CC] GO:0044459 plasma membrane part ABCB1, ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, CHRM2, CNR1, CNR2, F10, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PTGS2, PTPRS, SRC 4.68692
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA3, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, FLT3, FUT7, GLO1, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR 4.60211
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA3, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPRS, SRC, TBXAS1, TYR 3.31026
[CC] GO:0009330 None TOP1, TOP2A 2.81374
[CC] GO:0044464 cell part ABCB1, ACHE, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TOP2A, TUBB3, TYR, XDH 2.22253
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APEX1, APP, AURKB, BCL2, CA1, CA2, CA4, CA7, CBR1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2A, HTR4, HTR5A, KDR, KIT, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, PTGS1, PTGS2, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH 2.19397
[CC] GO:0043005 None APP, CA2, CHRM2, CNR1, CNR2, HTR2A, HTR2B, HTR5A, PTGS2, PTPRS, SRC, TUBB3 2.03982
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GLO1, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TOP2A, TUBB3, TYR, XDH 16.3749
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.2571
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.2571
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.2165
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.2165
[MF] GO:0099528 None CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.8677
[MF] GO:0008227 None CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 13.576
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, TBXAS1, TNKS, TYR, XDH 13.1177
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 12.163
[MF] GO:0003824 catalytic activity ABCB1, ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F10, FLT3, FUT7, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGS1, PTGS2, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TOP2A, TUBB3, TYR, XDH 10.6356
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 10.6143
[MF] GO:0030594 None CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 10.2629
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.80915
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 9.42481
[MF] GO:0070405 ammonium ion binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 9.18334
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 7.68995
[MF] GO:0038023 signaling receptor activity ADORA3, AXL, CHRM2, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PPARA 7.40433
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 6.76337
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TOP1, TOP2A 6.76198
[MF] GO:0004872 receptor activity ADORA3, AXL, CHRM2, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PPARA 6.45284
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 6.30621
[MF] GO:0060089 molecular transducer activity ADORA3, AXL, CHRM2, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PPARA 6.19922
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.93335
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1, POLB 5.68971
[MF] GO:0004871 signal transducer activity ADORA3, AXL, CHRM2, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PPARA 5.64434
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, TNKS 5.585
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, NQO2, POLA1, PTGS1, PTGS2, SRC, TBXAS1, XDH 5.3235
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1, TYR 5.25362
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 5.14752
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.98692
[MF] GO:0099600 transmembrane receptor activity ADORA3, AXL, CHRM2, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET 4.89147
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, AXL, CHRM2, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET 4.89147
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC, TBXAS1 4.76465
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.68962
[MF] GO:0016229 steroid dehydrogenase activity AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.55176
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC, TBXAS1 4.54982
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 4.47386
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.3068
[MF] GO:1901363 heterocyclic compound binding ABCB1, AOX1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, KIT, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, SRC, TBXAS1, TERT, TOP1, TOP2A, TUBB3, XDH 4.22581
[MF] GO:0097159 organic cyclic compound binding ABCB1, AOX1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, KIT, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, SRC, TBXAS1, TERT, TOP1, TOP2A, TUBB3, XDH 3.96798
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 3.77809
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, AOX1, XDH 3.75679
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 3.58427
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.54051
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.54051
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.47295
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.30407
[MF] GO:0004930 None ADORA3, CHRM2, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 3.29414
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.22532
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, POLA1, POLB, SRC, TERT, TOP1 3.18094
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.12483
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 2.93076
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 2.90546
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.81374
[MF] GO:0045550 None AKR1B10, AKR1C3 2.81374
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.81374
[MF] GO:0003845 None HSD11B1, HSD11B2 2.81374
[MF] GO:0071886 None HTR2A, HTR2C 2.81374
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIM1, SRC, TOP1 2.71526
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP1 2.60423
[MF] GO:0008289 lipid binding ALOX15, AXL, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, HSD11B2, HSD17B1, PPARA 2.58225
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.50718
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.41105
[MF] GO:0047718 None AKR1B10, AKR1C3 2.41105
[MF] GO:0004949 None CNR1, CNR2 2.41105
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, BCL2, CSNK2A1, ESR1, ESR2, FLT3, IGF1R, KDR, KIT, MET, MMP9, NQO2, PTGS2, TERT, TOP2A, TYR, XDH 2.40199
[MF] GO:0000166 nucleotide binding ABCB1, AOX1, AURKB, AXL, CSNK2A1, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, SRC, TOP1, TOP2A, TUBB3, XDH 2.3472
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AOX1, AURKB, AXL, CSNK2A1, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, SRC, TOP1, TOP2A, TUBB3, XDH 2.34543
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP1 2.273
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.25651
[MF] GO:0036094 small molecule binding ABCB1, AOX1, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, SRC, TOP1, TOP2A, TUBB3, XDH 2.25355
[MF] GO:0043168 anion binding ABCB1, ALOX15, AOX1, APP, AURKB, AXL, CSNK2A1, F10, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, PTPRS, SRC, TOP1, TOP2A, TUBB3, XDH 2.20736
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.1699


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR1E, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, ALOX5 17.6588
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, AKR1C3, CYP1B1, PTGS2, CYP19A1, IGF1R 10.6609
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, HTR1E, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, HTR5A, HTR4, HTR6, HTR7, CNR2, CNR1, ADORA3 10.6609
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AKR1C3, CYP1B1, CYP19A1 10.1417
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.6609
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, TBXAS1, AKR1C3, PTGS2, PTGS1 6.7305
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HTR6, PIK3CA, HTR1E, HTR1D, HTR1A, HTR1B, PIK3CB, PPARA, HTR4 6.6171
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1C3, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, HSD11B1, POLA1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 6.2756
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 5.5256
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, ESR2 5.5256
Pathways in cancer_Homo sapiens_hsa05200 PIK3CA, FLT3, MMP1, MMP2, KIT, BCL2, PIK3CB, PTGS2, MMP9, MET, IGF1R 4.942
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6, HTR7, HTR2B, HTR2C, HTR2A, HTR5A, HTR4 4.942
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, CNR1, KIT, KDR, PIK3CB, MET, IGF1R 4.4921
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, HTR2B, HTR2C, PIK3CB, HTR2A 4.4465
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2 4.8348
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, KIT, PIM1, PIK3CB 4.4344
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, PIK3CB, PTGS2, PTGS1 4.4465
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.3124
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.0024
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 3.8044
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, KIT, PIK3CB, MET 4.134
MicroRNAs in cancer_Homo sapiens_hsa05206 ABCB1, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET 3.6826
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, PIK3CA, KIT, KDR, PIK3CB, MET, IGF1R 3.5678
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 3.9944
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, PIK3CA, KIT, KDR, BCL2, PIK3CB, MET, IGF1R 3.3093
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB 3.437
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, PIK3CA, BCL2, PIK3CB 3.2722
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3, HTR2B, HTR2C, HTR2A 3.6826
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, TBXAS1, PIK3CB, PTGS1 3.0933
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, SRC, BCL2, PIK3CB, MMP9 2.8083
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.8044
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.7799
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, IGF1R 2.9905
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.6962
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B 2.7788
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, IGF1R 2.6962
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 2.934
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.8582
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0256
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 2.7314
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.3825
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB, IGF1R 2.4787
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.2986
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.2986
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.2986
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, PIK3CB 2.2809
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 1.8979
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB, IGF1R 2.0665
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 1.9169
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.7585
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 1.6371
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, IGF1R 2.1184
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 1.8094
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.1206
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, PIK3CA, SRC, PIK3CB 1.6278
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, PIK3CA, SRC, PIK3CB 1.5711
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, IGF1R 1.7165
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.1512
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 1.7525
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.1078
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.7585
Insulin resistance_Homo sapiens_hsa04931 PIK3CA, PIK3CB, PPARA 1.6278
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.5291
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.1184
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.3977
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.4396
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.5029
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB 1.4198
HTLV-I infection_Homo sapiens_hsa05166 POLB, PIK3CA, TERT, PIK3CB 1.3708
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.4396
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, KIT, PIK3CB 1.3712
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.3535
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.3561
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2655
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.3535
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2892
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.2892
Phagosome_Homo sapiens_hsa04145 TUBB3 0.3117
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3342
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, PIK3CB 1.2658
Axon guidance_Homo sapiens_hsa04360 MET 0.3674
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3751
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.1701
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.6838
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB 2.671
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.6838
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6805
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4259
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4364
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.8368
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.8456
Insulin signaling pathway_Homo sapiens_hsa04910 PIK3CA, PIK3CB 0.8271
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8271
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4519
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4512
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.468
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4699
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.469
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 1.024
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.9996
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.024
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.024
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0747
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.0098
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.0665
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.0306
Peroxisome_Homo sapiens_hsa04146 XDH 0.488
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.0098
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PTGS2 1.024
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5029
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.0962
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5256
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5239
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5382
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.2658
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.2335
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.2335
Shigellosis_Homo sapiens_hsa05131 SRC 0.5627
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.277
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.2466
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5899
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.2466
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2658
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.2602
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.3486
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.3708
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.4135
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.6202
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3535
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6461
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.4568
Malaria_Homo sapiens_hsa05144 MET 0.6584
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.5029
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.668
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6631
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6731
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6838
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7585
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7111
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.7683
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.6645
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7201
DNA replication_Homo sapiens_hsa03030 POLA1 0.7498
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6474
Base excision repair_Homo sapiens_hsa03410 POLB, APEX1 1.7075
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8066
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9363
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8271
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8526
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8447
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0704
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0827
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3535


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)