| GO Term |
GO Name |
Enriched Genes |
Log10 Adjusted P-value |
|
[BP] GO:0065008 |
regulation of biological quality
|
ACHE, ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CHRM1, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIN2B, GSK3B, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, INSR, KCNH2, KDR, KIT, MET, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCA, PTGS1, PTGS2, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TRPV1, XDH |
21.0087 |
|
[BP] GO:0042221 |
response to chemical
|
ADRA2A, AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CES1, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIN2B, GSK3B, HSD11B2, HSD17B2, HSPA1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IDO1, IGF1R, INSR, KCNH2, KDR, KIT, MMP2, MMP9, NR3C1, PIK3CA, POLB, PPARA, PRKCA, PTGS2, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP1, TRPV1, TYR |
20.0178 |
|
[BP] GO:0010033 |
response to organic substance
|
ADRA2A, AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIN2B, GSK3B, HSD11B2, HSD17B2, HSPA1A, HTR1B, HTR5A, IDO1, IGF1R, INSR, KDR, KIT, MMP2, NR3C1, PIK3CA, POLB, PPARA, PRKCA, PTGS2, RORC, SLC6A4, SMAD3, SRC, TEK, TRPV1, TYR |
16.5157 |
|
[BP] GO:1901700 |
response to oxygen-containing compound
|
AKR1B1, AKR1C3, ALPL, APEX1, APP, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, ESRRA, FABP3, GRIN2B, GSK3B, HSD11B2, HSD17B2, HTR1B, HTR5A, IDO1, IGF1R, INSR, MMP2, MMP9, NR3C1, PIK3CA, POLB, PPARA, PTGS2, RORC, SLC6A4, SRC, TEK, TRPV1, TYR |
16.5157 |
|
[BP] GO:0007210 |
None
|
HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 |
15.0864 |
|
[BP] GO:0098664 |
None
|
HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 |
15.0864 |
|
[BP] GO:0006629 |
lipid metabolic process
|
ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, APP, CBR1, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, EGFR, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1, TRPV1 |
14.9956 |
|
[BP] GO:0042127 |
regulation of cell proliferation
|
ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1C3, ALOX12, APP, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, IDO1, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, NUAK1, PIM1, PRKCA, PTGS1, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, XDH |
13.8156 |
|
[BP] GO:0010647 |
positive regulation of cell communication
|
ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, GSK3B, HCAR2, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH |
13.7207 |
|
[BP] GO:0023056 |
positive regulation of signaling
|
ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, GSK3B, HCAR2, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH |
13.6918 |
|
[BP] GO:0050896 |
response to stimulus
|
ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CES1, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, GRIN2B, GSK3B, HSD11B2, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IDO1, IGF1R, INSR, KCNH2, KDR, KIT, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP1, TOP2A, TRPV1, TYR |
13.6918 |
|
[BP] GO:0048522 |
positive regulation of cellular process
|
ACHE, ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GPR35, GRIN2B, GSK3B, HCAR2, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
13.41 |
|
[BP] GO:0042493 |
response to drug
|
AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, DHFR, EGFR, FABP3, GRIN2B, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KCNH2, KDR, NR3C1, POLB, PTGS2, SLC6A2, SLC6A4, SRC, TOP1, TRPV1 |
12.5918 |
|
[BP] GO:0019369 |
arachidonic acid metabolic process
|
AKR1C3, ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGS1, PTGS2, TBXAS1 |
12.5918 |
|
[BP] GO:0010941 |
regulation of cell death
|
ADORA1, AKR1B1, AKR1C3, ALOX12, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIN2B, GSK3B, HCAR2, HSPA1A, HTR2B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH |
12.379 |
|
[BP] GO:0033559 |
unsaturated fatty acid metabolic process
|
AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGS1, PTGS2, TBXAS1 |
12.3547 |
|
[BP] GO:0032501 |
multicellular organismal process
|
ADORA1, ADRA2A, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CHRM1, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, F10, F3, FABP4, GRIN2B, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IDO1, IGF1R, INSR, KCNH2, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TNKS2, TOP1, TRPV1, TYR |
12.3547 |
|
[BP] GO:0009967 |
positive regulation of signal transduction
|
ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, GSK3B, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH |
12.0122 |
|
[BP] GO:0009725 |
response to hormone
|
ADRA2A, AKR1B1, AKR1C3, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, INSR, KIT, NR3C1, PPARA, PTGS2, SLC6A4, SRC, TEK, TRPV1 |
12.0002 |
|
[BP] GO:0043067 |
regulation of programmed cell death
|
ADORA1, AKR1B1, AKR1C3, ALOX12, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GSK3B, HCAR2, HSPA1A, HTR2B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH |
12.0002 |
|
[BP] GO:0033993 |
response to lipid
|
AKR1C3, ALPL, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, IDO1, NR3C1, PTGS2, RORC, SLC6A4, SRC, TYR |
12.0002 |
|
[BP] GO:0009719 |
response to endogenous stimulus
|
ADRA2A, AKR1B1, AKR1C3, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GSK3B, HSD11B2, HTR1B, HTR5A, IGF1R, INSR, KIT, MMP2, NR3C1, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TRPV1 |
12.0002 |
|
[BP] GO:0006690 |
icosanoid metabolic process
|
AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGS1, PTGS2, TBXAS1 |
11.9993 |
|
[BP] GO:0014070 |
response to organic cyclic compound
|
AKR1C3, ALPL, APEX1, APP, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, ESRRA, FLT3, HSD11B2, HTR1B, HTR5A, NR3C1, PTGS2, RORC, SLC6A4, SRC, TEK, TRPV1, TYR |
11.9503 |
|
[BP] GO:0048518 |
positive regulation of biological process
|
ACHE, ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIN2B, GSK3B, HCAR2, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
11.8935 |
|
[BP] GO:0044281 |
small molecule metabolic process
|
AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DHFR, FABP3, FUT7, GBA2, GLO1, HSPA1A, HTR2B, HTR2C, IDO1, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR, XDH |
11.8425 |
|
[BP] GO:0008152 |
metabolic process
|
ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GRIN2B, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IDO1, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TYR, XDH |
11.5261 |
|
[BP] GO:0008202 |
steroid metabolic process
|
AKR1B1, AKR1B10, AKR1C3, APP, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
11.3971 |
|
[BP] GO:1902533 |
positive regulation of intracellular signal transduction
|
ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MET, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH |
11.3071 |
|
[BP] GO:0032879 |
regulation of localization
|
ACHE, ADORA1, ADORA3, ADRA2A, ALOX12, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA7, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, GPR35, GSK3B, HCAR2, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1 |
10.8005 |
|
[BP] GO:0008284 |
positive regulation of cell proliferation
|
ADRA2A, AKR1B1, AKR1C3, ALOX12, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, EGFR, ESR1, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS2, TEK, TERT |
10.7461 |
|
[BP] GO:0042981 |
regulation of apoptotic process
|
ADORA1, AKR1B1, AKR1C3, ALOX12, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GSK3B, HCAR2, HSPA1A, HTR2B, IDO1, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH |
10.7157 |
|
[BP] GO:0055114 |
oxidation-reduction process
|
AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DHFR, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH |
10.6275 |
|
[BP] GO:0048584 |
positive regulation of response to stimulus
|
ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESRRA, F10, F3, FABP4, FLT3, GPR35, GSK3B, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IDO1, INSR, KDR, KIT, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH |
10.5072 |
|
[BP] GO:0010646 |
regulation of cell communication
|
ACHE, ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, GSK3B, HCAR2, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH |
10.365 |
|
[BP] GO:0070887 |
cellular response to chemical stimulus
|
ADRA2A, AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GSK3B, HSPA1A, HTR1B, IGF1R, INSR, KCNH2, KDR, KIT, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SLC6A4, SMAD3, SRC, TERT, TRPV1 |
10.1732 |
|
[BP] GO:0023051 |
regulation of signaling
|
ACHE, ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, GSK3B, HCAR2, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH |
10.1575 |
|
[BP] GO:0048523 |
negative regulation of cellular process
|
ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1C3, ALOX12, APEX1, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, GRIN2B, GSK3B, HSPA1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IDO1, IGF1R, KCNH2, KDR, KIT, MET, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
9.96889 |
|
[BP] GO:0007187 |
None
|
ADORA1, ADRA2A, CHRM1, CHRM2, CHRM4, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 |
9.95847 |
|
[BP] GO:0044237 |
cellular metabolic process
|
ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GRIN2B, GSK3B, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IDO1, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP1, MMP2, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH |
9.93753 |
|
[BP] GO:0040012 |
regulation of locomotion
|
ADORA1, ADORA3, ADRA2A, ALOX12, APEX1, APP, BCL2, CDK6, CHRM1, CHRM4, CYP19A1, CYP1B1, EGFR, F10, F3, HTR1D, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK, TERT |
9.91937 |
|
[BP] GO:0044255 |
cellular lipid metabolic process
|
ACHE, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, EGFR, FABP3, FABP4, FUT7, GBA2, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 |
9.90205 |
|
[BP] GO:1901568 |
fatty acid derivative metabolic process
|
AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGS1, PTGS2, TBXAS1 |
9.76314 |
|
[BP] GO:0003018 |
None
|
ADORA1, ADRA2A, CHRM1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4, SRC, TEK |
9.76314 |
|
[BP] GO:0001676 |
long-chain fatty acid metabolic process
|
AKR1C3, ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGS1, PTGS2, TBXAS1 |
9.56915 |
|
[BP] GO:0007193 |
None
|
ADORA1, ADRA2A, CHRM1, CHRM2, CHRM4, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 |
9.525 |
|
[BP] GO:0043069 |
negative regulation of programmed cell death
|
ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, GSK3B, HSPA1A, HTR2B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT |
9.39854 |
|
[BP] GO:0097756 |
None
|
ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 |
9.37664 |
|
[BP] GO:0060548 |
negative regulation of cell death
|
ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, GSK3B, HSPA1A, HTR2B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT |
9.2976 |
|
[BP] GO:0042592 |
homeostatic process
|
ADORA1, ADRA2A, AKR1B1, ALOX12, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, CNR1, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, GRIN2B, HTR2A, HTR2B, HTR2C, INSR, KCNH2, MET, PIK3CA, PIK3CB, POLA1, POLB, SMAD3, SRC, TERT, TRPV1 |
9.17106 |
|
[BP] GO:0006631 |
fatty acid metabolic process
|
AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, PPARA, PTGS1, PTGS2, TBXAS1 |
9.16188 |
|
[BP] GO:0048519 |
negative regulation of biological process
|
ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1C3, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, GRIN2B, GSK3B, HCAR2, HSPA1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IDO1, IGF1R, KCNH2, KDR, KIT, MET, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
9.12387 |
|
[BP] GO:0032502 |
developmental process
|
ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CES1, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, GSK3B, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PRKCA, PTGS2, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS2, TOP2A, TYR |
9.11654 |
|
[BP] GO:1902531 |
regulation of intracellular signal transduction
|
ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH |
9.1109 |
|
[BP] GO:0010817 |
regulation of hormone levels
|
ACHE, ADORA1, ADRA2A, AKR1B1, AKR1C3, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2C, PRKCA |
9.09962 |
|
[BP] GO:0071310 |
cellular response to organic substance
|
ADRA2A, AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, GSK3B, HTR1B, IGF1R, INSR, KDR, KIT, MMP2, NR3C1, PIK3CA, PTGS2, RORC, SLC6A4, SMAD3, SRC, TRPV1 |
9.01363 |
|
[BP] GO:0007165 |
signal transduction
|
ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1C3, APP, AXL, BCL2, CA1, CA2, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIN2B, GSK3B, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 |
8.80505 |
|
[BP] GO:0006796 |
phosphate-containing compound metabolic process
|
ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DHFR, DUSP3, EGFR, FLT3, GRIN2B, GSK3B, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KCNH2, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLB, PRKCA, PTGS2, PTPN1, SRC, TEK, TNKS, TOP1, XDH |
8.80505 |
|
[BP] GO:0032844 |
regulation of homeostatic process
|
ADORA1, ADRA2A, AURKB, BCL2, CA2, CA7, CDK6, CNR1, EGFR, HCAR2, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2, TRPV1 |
8.73603 |
|
[BP] GO:0032787 |
None
|
AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, GBA2, GLO1, IDO1, PPARA, PTGS1, PTGS2, TBXAS1 |
8.6753 |
|
[BP] GO:0097746 |
None
|
ADORA1, ADRA2A, CHRM1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 |
8.55395 |
|
[BP] GO:0035296 |
None
|
ADORA1, ADRA2A, CHRM1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 |
8.55395 |
|
[BP] GO:0051716 |
cellular response to stimulus
|
ADRA2A, AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, FABP4, FLT3, GSK3B, HSPA1A, HTR1B, IGF1R, INSR, KCNH2, KDR, KIT, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, POLA1, POLB, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TERT, TOP2A, TRPV1 |
8.49176 |
|
[BP] GO:0044238 |
primary metabolic process
|
ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CES1, CES2, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GRIN2B, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR2B, HTR2C, IDO1, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TYR, XDH |
8.45411 |
|
[BP] GO:2000145 |
regulation of cell motility
|
ADORA1, ADORA3, ADRA2A, ALOX12, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK, TERT |
8.41306 |
|
[BP] GO:0030335 |
positive regulation of cell migration
|
ADRA2A, ALOX12, APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK, TERT |
8.39033 |
|
[BP] GO:0048583 |
regulation of response to stimulus
|
ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GPR35, GSK3B, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH |
8.38023 |
|
[BP] GO:0019748 |
secondary metabolic process
|
AKR1B1, AKR1B10, AKR1C3, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR |
8.37828 |
|
[BP] GO:0071704 |
organic substance metabolic process
|
ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CES1, CES2, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GRIN2B, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IDO1, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TYR, XDH |
8.37337 |
|
[BP] GO:0003013 |
None
|
ADORA1, ADRA2A, CHRM1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4, SRC, TEK |
8.28608 |
|
[BP] GO:0050880 |
None
|
ADORA1, ADRA2A, CHRM1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 |
8.28227 |
|
[BP] GO:0006793 |
phosphorus metabolic process
|
ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DHFR, DUSP3, EGFR, FLT3, GRIN2B, GSK3B, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KCNH2, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLB, PRKCA, PTGS2, PTPN1, SRC, TEK, TNKS, TOP1, XDH |
8.27601 |
|
[BP] GO:0035150 |
None
|
ADORA1, ADRA2A, CHRM1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 |
8.25215 |
|
[BP] GO:0030334 |
regulation of cell migration
|
ADORA1, ADORA3, ADRA2A, ALOX12, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK, TERT |
8.22412 |
|
[BP] GO:2000147 |
positive regulation of cell motility
|
ADRA2A, ALOX12, APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK, TERT |
8.16901 |
|
[BP] GO:0043066 |
negative regulation of apoptotic process
|
ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, GSK3B, HSPA1A, HTR2B, IDO1, IGF1R, KDR, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT |
8.11262 |
|
[BP] GO:0010035 |
response to inorganic substance
|
AKR1B1, AKR1C3, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, KIT, MMP9, PTGS2, SRC, TERT |
8.11262 |
|
[BP] GO:0006468 |
protein phosphorylation
|
APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, FLT3, GRIN2B, GSK3B, HTR2B, IGF1R, INSR, KCNH2, KDR, KIT, MET, NUAK1, PIK3CA, PIM1, PRKCA, SRC, TEK, TNKS, TOP1 |
8.04873 |
|
[BP] GO:0051272 |
positive regulation of cellular component movement
|
ADRA2A, ALOX12, APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK, TERT |
7.98151 |
|
[BP] GO:0019216 |
regulation of lipid metabolic process
|
ADORA1, ADRA2A, AKR1C3, CNR1, CYP1A1, FABP3, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, KIT, PPARA, PTGS2, RORC, SRC, TEK |
7.92827 |
|
[BP] GO:0007186 |
G-protein coupled receptor signaling pathway
|
ADORA1, ADORA3, ADRA2A, AKR1C3, APP, CA2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, GPR35, GSK3B, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, INSR, PIK3CA, PIK3CB, SRC |
7.806 |
|
[BP] GO:0006805 |
xenobiotic metabolic process
|
CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, NQO2, PTGS1, RORC |
7.78138 |
|
[BP] GO:0040017 |
positive regulation of locomotion
|
ADRA2A, ALOX12, APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK, TERT |
7.74988 |
|
[BP] GO:0051270 |
regulation of cellular component movement
|
ADORA1, ADORA3, ADRA2A, ALOX12, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PTGS2, SMAD3, SRC, TEK, TERT |
7.74988 |
|
[BP] GO:0051049 |
regulation of transport
|
ACHE, ADORA1, ADRA2A, ALOX15, APP, AXL, BCL2, CA2, CA7, CHRM1, CNR1, CYP19A1, EGFR, GPR35, GSK3B, HCAR2, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, INSR, KCNH2, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, TRPV1 |
7.6928 |
|
[BP] GO:0051897 |
positive regulation of protein kinase B signaling
|
AKR1C3, AXL, EGFR, F10, F3, INSR, KIT, MET, PIK3CA, PIK3CB, SRC, TEK |
7.64453 |
|
[BP] GO:1903727 |
positive regulation of phospholipid metabolic process
|
FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, SRC, TEK |
7.53739 |
|
[BP] GO:0007188 |
None
|
ADORA1, ADRA2A, CHRM1, CHRM2, CHRM4, CNR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 |
7.52356 |
|
[BP] GO:0051239 |
regulation of multicellular organismal process
|
ADORA1, ADORA3, ADRA2A, ALOX12, APP, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CNR1, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, GSK3B, HCAR2, HSPA1A, HTR2A, HTR2B, HTR2C, IDO1, INSR, KCNH2, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS2, TRPV1, XDH |
7.40397 |
|
[BP] GO:0009636 |
response to toxic substance
|
AKR1B1, ALPL, APEX1, AXL, BCL2, CES1, CNR1, CNR2, CYP1A1, CYP1B1, GRIN2B, HTR1B, HTR1D, KDR, POLB, SLC6A4, SRC |
7.3013 |
|
[BP] GO:0048878 |
chemical homeostasis
|
ADRA2A, AKR1B1, ALOX12, APP, BCL2, CA12, CA2, CA7, CNR1, EGFR, ESR1, FABP3, FABP4, GPR35, GRIN2B, HTR2A, HTR2B, HTR2C, INSR, KCNH2, MET, PIK3CA, PIK3CB, SMAD3, TRPV1 |
7.28137 |
|
[BP] GO:0042310 |
None
|
HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, SLC6A4 |
7.24967 |
|
[BP] GO:0080134 |
regulation of response to stress
|
ADORA1, ADRA2A, ALOX12, APP, CDK6, CNR1, CNR2, CYP19A1, DHFR, DUSP3, EGFR, ESR1, F3, FABP4, GSK3B, HSPA1A, IDO1, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH |
7.20235 |
|
[BP] GO:0051896 |
regulation of protein kinase B signaling
|
AKR1C3, AXL, EGFR, F10, F3, INSR, KIT, MET, PIK3CA, PIK3CB, SRC, TEK, XDH |
7.12678 |
|
[BP] GO:0016310 |
phosphorylation
|
APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, FLT3, GRIN2B, GSK3B, HTR2B, IGF1R, INSR, KCNH2, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TEK, TNKS, TOP1 |
6.89338 |
|
[BP] GO:0010243 |
response to organonitrogen compound
|
AKR1B1, APEX1, APP, CNR1, CNR2, DHFR, EGFR, FABP3, FLT3, GSK3B, HSD11B2, HTR1B, IGF1R, INSR, MMP2, PPARA, PTGS2, SLC6A4, SRC, TEK, TRPV1, TYR |
6.88098 |
|
[BP] GO:0009893 |
positive regulation of metabolic process
|
ADORA1, ADRA2A, AKR1C3, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DHFR, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GSK3B, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
6.84005 |
|
[BP] GO:0009628 |
response to abiotic stimulus
|
ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, HSD11B2, HSPA1A, HTR1B, HTR2A, HTR2B, KIT, MMP2, POLB, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, TYR |
6.77056 |
|
[BP] GO:0009987 |
cellular process
|
ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, GRIN2B, GSK3B, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TYR, XDH |
6.77056 |
|
[BP] GO:0042445 |
hormone metabolic process
|
ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
6.72129 |
|
[BP] GO:0007198 |
None
|
HTR1A, HTR1B, HTR5A, HTR7 |
6.71345 |
|
[BP] GO:0019752 |
carboxylic acid metabolic process
|
AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DHFR, FABP3, GBA2, GLO1, IDO1, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR |
6.66182 |
|
[BP] GO:0019220 |
regulation of phosphate metabolic process
|
ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
6.65908 |
|
[BP] GO:0010562 |
positive regulation of phosphorus metabolic process
|
ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
6.65252 |
|
[BP] GO:0045937 |
positive regulation of phosphate metabolic process
|
ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
6.65252 |
|
[BP] GO:0043410 |
positive regulation of MAPK cascade
|
ADORA1, ADRA2A, ALOX15, APP, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, PIK3CB, PRKCA, PTPN1, SRC, TEK, XDH |
6.63498 |
|
[BP] GO:0031325 |
positive regulation of cellular metabolic process
|
ADORA1, ADRA2A, AKR1C3, ALOX15, APP, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GSK3B, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
6.59958 |
|
[BP] GO:0006730 |
one-carbon metabolic process
|
CA1, CA12, CA2, CA4, CA7, CA9, DHFR |
6.59958 |
|
[BP] GO:0048511 |
rhythmic process
|
AXL, BCL2, CSNK2A1, EGFR, ESR1, GSK3B, HTR7, KIT, PPARA, RORC, SLC6A4, SRC, TOP1, TOP2A |
6.59958 |
|
[BP] GO:0051174 |
regulation of phosphorus metabolic process
|
ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
6.59188 |
|
[BP] GO:0051173 |
positive regulation of nitrogen compound metabolic process
|
ADORA1, ADRA2A, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GSK3B, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
6.58637 |
|
[BP] GO:0003008 |
None
|
ADORA1, ADRA2A, AKR1B1, AKR1C3, APP, BCL2, CHRM1, CNR1, CNR2, CYP1B1, EGFR, GRIN2B, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, INSR, KCNH2, KIT, PIK3CA, PTGS2, SLC6A4, SRC, TEK, TRPV1, TYR |
6.50781 |
|
[BP] GO:0046777 |
protein autophosphorylation
|
AURKB, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, KIT, PIM1, SRC, TEK |
6.47992 |
|
[BP] GO:0006950 |
response to stress
|
ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, GSK3B, HSD11B2, HSPA1A, HTR1A, HTR2C, IDO1, KIT, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1 |
6.47901 |
|
[BP] GO:0042446 |
hormone biosynthetic process
|
AKR1B1, AKR1C3, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
6.37899 |
|
[BP] GO:0071407 |
cellular response to organic cyclic compound
|
AKR1C3, ALPL, APEX1, APP, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, NR3C1, PTGS2, RORC, SLC6A4, SRC, TRPV1 |
6.37773 |
|
[BP] GO:0019371 |
None
|
AKR1C3, CBR1, PTGS1, PTGS2, TBXAS1 |
6.35357 |
|
[BP] GO:0099536 |
None
|
CHRM1, CHRM2, CHRM4, CNR1, GRIN2B, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, SLC6A2 |
6.34867 |
|
[BP] GO:0099537 |
None
|
CHRM1, CHRM2, CHRM4, CNR1, GRIN2B, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, SLC6A2 |
6.34867 |
|
[BP] GO:1901698 |
response to nitrogen compound
|
AKR1B1, APEX1, APP, CNR1, CNR2, DHFR, EGFR, FABP3, FLT3, GSK3B, HSD11B2, HTR1B, IGF1R, INSR, MMP2, PPARA, PTGS2, SLC6A4, SRC, TEK, TRPV1, TYR |
6.3458 |
|
[BP] GO:0045834 |
positive regulation of lipid metabolic process
|
FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PPARA, PTGS2, SRC, TEK |
6.32789 |
|
[BP] GO:1901615 |
organic hydroxy compound metabolic process
|
AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, APP, BCL2, CES1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, GBA2, HTR1A, TYR |
6.31184 |
|
[BP] GO:1901701 |
cellular response to oxygen-containing compound
|
AKR1B1, AKR1C3, APEX1, APP, AXL, CDK6, CYP1B1, EGFR, ESR1, GSK3B, IGF1R, INSR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SLC6A4, SRC, TRPV1 |
6.27924 |
|
[BP] GO:0042327 |
positive regulation of phosphorylation
|
ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, EGFR, ESRRB, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH |
6.269 |
|
[BP] GO:0009966 |
regulation of signal transduction
|
ADORA1, ADRA2A, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, GSK3B, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH |
6.26353 |
|
[BP] GO:0071495 |
cellular response to endogenous stimulus
|
ADRA2A, AKR1B1, AKR1C3, APEX1, APP, EGFR, ESR1, FLT3, GSK3B, HTR1B, IGF1R, INSR, KIT, MMP2, NR3C1, PTGS2, SLC6A4, SMAD3, SRC, TRPV1 |
6.26086 |
|
[BP] GO:0008610 |
lipid biosynthetic process
|
ACHE, AKR1B1, AKR1C3, ALOX12, ALOX15, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 |
6.169 |
|
[BP] GO:0009892 |
negative regulation of metabolic process
|
ADORA1, ADRA2A, AKR1C3, APEX1, APP, AURKB, BCL2, CNR1, CNR2, CSNK2A1, CYP2D6, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GSK3B, HCAR2, HSPA1A, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1, XDH |
6.13605 |
|
[BP] GO:0065007 |
biological regulation
|
ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1C3, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIN2B, GSK3B, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, XDH |
6.13055 |
|
[BP] GO:0048513 |
animal organ development
|
ACHE, AKR1C3, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, KIT, PIK3CA, POLB, PPARA, SMAD3, SRC, TEK, TYR |
6.06614 |
|
[BP] GO:0015701 |
bicarbonate transport
|
CA1, CA12, CA14, CA2, CA4, CA7, CA9 |
6.03222 |
|
[BP] GO:0007169 |
transmembrane receptor protein tyrosine kinase signaling pathway
|
AXL, EGFR, FLT3, GRIN2B, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC, TEK |
6.03222 |
|
[BP] GO:0010604 |
positive regulation of macromolecule metabolic process
|
ADORA1, ADRA2A, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GSK3B, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH |
5.97669 |
|
[BP] GO:0001934 |
positive regulation of protein phosphorylation
|
ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH |
5.97269 |
|
[BP] GO:0043436 |
oxoacid metabolic process
|
AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DHFR, FABP3, GBA2, GLO1, IDO1, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR |
5.95798 |
|
[BP] GO:0007154 |
None
|
ADORA1, AKR1C3, AXL, BCL2, CHRM1, CHRM2, CHRM4, CNR1, ESR2, GRIN2B, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PTGS2, SLC6A2, TEK, TRPV1 |
5.95595 |
|
[BP] GO:0050790 |
regulation of catalytic activity
|
ADORA1, ADORA3, ADRA2A, APP, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GSK3B, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH |
5.93966 |
|
[BP] GO:0043408 |
regulation of MAPK cascade
|
ADORA1, ADRA2A, ALOX15, APP, DUSP3, EGFR, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, PIK3CB, PRKCA, PTPN1, SRC, TEK, XDH |
5.93966 |
|
[BP] GO:1903725 |
regulation of phospholipid metabolic process
|
FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, SRC, TEK |
5.8725 |
|
[BP] GO:0006082 |
organic acid metabolic process
|
AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DHFR, FABP3, GBA2, GLO1, IDO1, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR |
5.82853 |
|
[BP] GO:0043271 |
negative regulation of ion transport
|
ADORA1, ADRA2A, BCL2, CNR1, GPR35, HTR1B, HTR2A, KCNH2, MMP9, PTGS2 |
5.81951 |
|
[BP] GO:0035690 |
cellular response to drug
|
AKR1B1, APEX1, AXL, CDK6, CYP1B1, EGFR, HTR1B, KCNH2, KDR, NR3C1, PTGS2, SRC, TRPV1 |
5.76605 |
|
[BP] GO:0032845 |
None
|
ADORA1, ADRA2A, BCL2, HTR2A, HTR2B, HTR2C, SRC, TNKS, TNKS2, TRPV1 |
5.73615 |
|
[BP] GO:0006721 |
terpenoid metabolic process
|
AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, EGFR |
5.73409 |
|
[BP] GO:0065009 |
regulation of molecular function
|
ADORA1, ADORA3, ADRA2A, APP, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, DHFR, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, GRIN2B, GSK3B, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KIT, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TRPV1, XDH |
5.70407 |
|
[BP] GO:0034754 |
cellular hormone metabolic process
|
AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 |
5.70297 |
|
[BP] GO:0016098 |
monoterpenoid metabolic process
|
CYP1A2, CYP2C19, CYP2D6, CYP3A4 |
5.68842 |
|
[BP] GO:0051240 |
positive regulation of multicellular organismal process
|
ADRA2A, ALOX12, APP, AXL, BCL2, CA2, CNR1, CYP1B1, EGFR, ESRRB, F3, HCAR2, HSPA1A, HTR2A, HTR2B, IDO1, KDR, KIT, MET, MMP12, MMP9, PIM1, PRKCA, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1 |
5.63409 |
|
[BP] GO:0070482 |
response to oxygen levels
|
ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, POLB, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT |
5.62009 |
|
[BP] GO:0007268 |
None
|
CHRM1, CHRM2, CHRM4, GRIN2B, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, SLC6A2 |
5.60686 |
|
[BP] GO:0098916 |
None
|
CHRM1, CHRM2, CHRM4, GRIN2B, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, SLC6A2 |
5.60686 |
|
[BP] GO:1901564 |
organonitrogen compound metabolic process
|
ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, CYP3A4, DHFR, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, GRIN2B, GSK3B, HSPA1A, HTR1A, HTR2B, HTR2C, IDO1, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, POLB, PPARA, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH |
5.60295 |
|
[BP] GO:0009894 |
regulation of catabolic process
|
ADORA1, ADRA2A, APEX1, BCL2, CNR1, CSNK2A1, EGFR, ESRRB, GSK3B, HCAR2, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PTPN1, SMAD3 |
5.5933 |
|
[BP] GO:0007610 |
None
|
APP, BCL2, CNR1, EGFR, GRIN2B, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IDO1, INSR, KIT, PPARA, PTGS2, SLC6A4, TRPV1 |
5.58776 |
|
[BP] GO:0050804 |
modulation of chemical synaptic transmission
|
ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, EGFR, HTR1B, HTR2A, KIT, PTGS2, SLC6A4 |
5.46221 |
|
[BP] GO:0099177 |
regulation of trans-synaptic signaling
|
ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, EGFR, HTR1B, HTR2A, KIT, PTGS2, SLC6A4 |
5.46221 |
|
[BP] GO:0031960 |
response to corticosteroid
|
AKR1C3, ALPL, BCL2, EGFR, FLT3, HSD11B2, HTR1B, NR3C1, PTGS2, SRC |
5.46103 |
|
[BP] GO:0032228 |
regulation of synaptic transmission, GABAergic
|
ADORA1, CA2, CA7, CNR1, CNR2, HTR1B |
5.4594 |
|
[BP] GO:0019222 |
regulation of metabolic process
|
ACHE, ADORA1, ADORA3, ADRA2A, AKR1C3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GSK3B, HCAR2, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, XDH |
5.40124 |
|
[BP] GO:0048856 |
anatomical structure development
|
ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, GBA2, GSK3B, HSD11B1, HSD17B2, HTR5A, INSR, KDR, KIT, MMP9, PIK3CA, PIM1, POLB, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR |
5.32148 |
|
[BP] GO:0007200 |
None
|
ADRA2A, CHRM1, CHRM2, CHRM4, ESR1, HTR2A, HTR2B, HTR2C |
5.27314 |
|
[BP] GO:0001666 |
response to hypoxia
|
ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT |
5.27314 |
|
[BP] GO:0042325 |
regulation of phosphorylation
|
ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH |
5.26132 |
|
[BP] GO:0051050 |
positive regulation of transport
|
ACHE, ADORA1, ADRA2A, APP, AXL, BCL2, CA2, CHRM1, CYP19A1, EGFR, GSK3B, HCAR2, HTR2B, INSR, KCNH2, MMP12, PTGS2, SLC6A4, SMAD3, SRC, TERT, TRPV1 |
5.2246 |
|
[BP] GO:0006720 |
isoprenoid metabolic process
|
AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, EGFR |
5.19843 |
|
[BP] GO:0010038 |
response to metal ion
|
AKR1C3, ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, KIT, MMP9, PTGS2, TERT |
5.19764 |
|
[BP] GO:0051247 |
positive regulation of protein metabolic process
|
ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, F3, FLT3, GSK3B, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
5.17435 |
|
[BP] GO:0006694 |
steroid biosynthetic process
|
AKR1B1, AKR1C3, CES1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
5.17435 |
|
[BP] GO:0008283 |
cell proliferation
|
ACHE, AURKB, BCL2, CHRM1, CHRM4, CYP1A1, EGFR, ESR1, FLT3, HTR1A, KIT, MET, PIK3CB, PIM1, POLA1, SRC, TEK, TYR |
5.16042 |
|
[BP] GO:0036293 |
response to decreased oxygen levels
|
ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT |
5.14647 |
|
[BP] GO:2000377 |
regulation of reactive oxygen species metabolic process
|
AKR1C3, BCL2, CYP1B1, DHFR, EGFR, INSR, PTGS2, SMAD3, TRPV1, XDH |
5.14354 |
|
[BP] GO:0032270 |
positive regulation of cellular protein metabolic process
|
ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, GSK3B, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
5.11864 |
|
[BP] GO:0044057 |
None
|
ADORA1, ADORA3, ADRA2A, CHRM1, CHRM2, EGFR, GPR35, HCAR2, HTR2A, HTR2C, KCNH2, KIT, PRKCA, PTGS2, SMAD3, TRPV1 |
5.08444 |
|
[BP] GO:0048545 |
response to steroid hormone
|
AKR1C3, ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2, HTR1B, NR3C1, PTGS2, SRC |
5.08444 |
|
[BP] GO:0044092 |
negative regulation of molecular function
|
ADORA3, ADRA2A, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, DUSP3, ESR1, FABP4, GPR35, GSK3B, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PTGS2, PTPN1, SRC, TNKS |
5.03853 |
|
[BP] GO:0070372 |
regulation of ERK1 and ERK2 cascade
|
ALOX15, APP, DUSP3, EGFR, HTR2A, HTR2B, HTR2C, KDR, PRKCA, PTPN1, SRC, TEK |
5.03552 |
|
[BP] GO:0017144 |
drug metabolic process
|
ACHE, AKR1B1, AKR1B10, AKR1C3, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DHFR, EGFR, HSPA1A, IDO1 |
4.98874 |
|
[BP] GO:0050805 |
negative regulation of synaptic transmission
|
ACHE, ADORA1, CNR2, HTR1B, HTR2A, PTGS2, SLC6A4 |
4.98807 |
|
[BP] GO:0050795 |
None
|
ADORA1, CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B |
4.98807 |
|
[BP] GO:0007167 |
enzyme linked receptor protein signaling pathway
|
AXL, EGFR, FLT3, GRIN2B, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SMAD3, SRC, TEK |
4.9879 |
|
[BP] GO:0043405 |
regulation of MAP kinase activity
|
ADORA1, ADRA2A, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, KIT, PIK3CB, PTPN1, SRC |
4.90717 |
|
[BP] GO:0010648 |
negative regulation of cell communication
|
ACHE, ADORA1, ADRA2A, BCL2, CNR2, DUSP3, EGFR, ESR1, ESR2, GPR35, GSK3B, HSPA1A, HTR1B, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH |
4.88927 |
|
[BP] GO:0001932 |
regulation of protein phosphorylation
|
ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH |
4.88666 |
|
[BP] GO:0006979 |
response to oxidative stress
|
AKR1B1, AKR1C3, APEX1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC |
4.87089 |
|
[BP] GO:0023057 |
negative regulation of signaling
|
ACHE, ADORA1, ADRA2A, BCL2, CNR2, DUSP3, EGFR, ESR1, ESR2, GPR35, GSK3B, HSPA1A, HTR1B, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH |
4.87089 |
|
[BP] GO:0050794 |
regulation of cellular process
|
ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1C3, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIN2B, GSK3B, HCAR2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
4.86577 |
|
[BP] GO:0071073 |
None
|
FABP3, HTR2A, HTR2B, HTR2C |
4.86577 |
|
[BP] GO:0048585 |
negative regulation of response to stimulus
|
ADORA1, ADRA2A, ALOX12, ALOX15, BCL2, CDK6, CNR1, CNR2, CYP19A1, DUSP3, EGFR, ESR1, ESR2, GSK3B, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH |
4.83862 |
|
[BP] GO:0031324 |
negative regulation of cellular metabolic process
|
ADRA2A, AKR1C3, APEX1, APP, AURKB, BCL2, CNR1, CSNK2A1, CYP2D6, DHFR, DUSP3, ESR1, ESR2, ESRRA, FABP4, GSK3B, HSPA1A, HTR1B, HTR1E, HTR2B, IGF1R, MET, MMP12, MMP9, NR3C1, PIK3CA, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1, XDH |
4.8285 |
|
[BP] GO:1901652 |
response to peptide
|
AKR1B1, APEX1, APP, FABP3, GSK3B, HSD11B2, IGF1R, INSR, PPARA, PTGS2, SRC, TEK, TRPV1 |
4.79821 |
|
[BP] GO:0018108 |
peptidyl-tyrosine phosphorylation
|
AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK |
4.79748 |
|
[BP] GO:0023052 |
None
|
ADORA1, CHRM1, CHRM2, CHRM4, CNR1, ESR2, GRIN2B, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, KCNH2, SLC6A2, TEK |
4.78972 |
|
[BP] GO:0001952 |
regulation of cell-matrix adhesion
|
BCL2, CDK6, GSK3B, KDR, PIK3CB, SMAD3, SRC, TEK |
4.76752 |
|
[BP] GO:0007267 |
None
|
ADORA1, CHRM1, CHRM2, CHRM4, CNR1, ESR2, GRIN2B, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, SLC6A2, TEK |
4.75056 |
|
[BP] GO:0018212 |
peptidyl-tyrosine modification
|
AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK |
4.73974 |
|
[BP] GO:0050999 |
None
|
CNR1, CNR2, DHFR, EGFR, HTR2B, TERT |
4.68259 |
|
[BP] GO:0097267 |
omega-hydroxylase P450 pathway
|
CYP1A1, CYP1A2, CYP1B1, CYP2C19 |
4.66516 |
|
[BP] GO:0043085 |
positive regulation of catalytic activity
|
ADORA1, ADRA2A, APP, AURKB, BCL2, CDC25B, DHFR, EGFR, ESR1, F3, FLT3, GSK3B, HSPA1A, HTR2A, HTR2B, INSR, KIT, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH |
4.66289 |
|
[BP] GO:0034614 |
cellular response to reactive oxygen species
|
AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC |
4.61819 |
|
[BP] GO:0070374 |
positive regulation of ERK1 and ERK2 cascade
|
ALOX15, APP, EGFR, HTR2A, HTR2B, HTR2C, KDR, PRKCA, SRC, TEK |
4.58127 |
|
[BP] GO:0044093 |
positive regulation of molecular function
|
ADORA1, ADRA2A, APP, AURKB, BCL2, CDC25B, DHFR, EGFR, ESR1, ESR2, F3, FLT3, GSK3B, HSPA1A, HTR2A, HTR2B, INSR, KIT, MET, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH |
4.55611 |
|
[BP] GO:0090066 |
None
|
ADORA1, ADRA2A, ALOX15, CHRM1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SLC6A4 |
4.54225 |
|
[BP] GO:0048661 |
positive regulation of smooth muscle cell proliferation
|
AKR1B1, EGFR, HTR1B, MMP2, MMP9, PTGS2, TERT |
4.51541 |
|
[BP] GO:0001505 |
regulation of neurotransmitter levels
|
ACHE, CYP1B1, DHFR, EGFR, HTR1A, INSR, PTGS2, SLC6A2, SLC6A4, SMAD3, TRPV1 |
4.4821 |
|
[BP] GO:0007346 |
regulation of mitotic cell cycle
|
APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, SMAD3, TERT, TNKS, TOP2A |
4.45832 |
|
[BP] GO:0010942 |
positive regulation of cell death
|
AKR1C3, BCL2, CNR1, CYP1B1, F3, GRIN2B, GSK3B, HCAR2, IDO1, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH |
4.4433 |
|
[BP] GO:2000021 |
regulation of ion homeostasis
|
ADORA1, BCL2, CA2, CA7, HTR2A, HTR2B, HTR2C, KDR, SRC, TRPV1 |
4.382 |
|
[BP] GO:0050801 |
ion homeostasis
|
APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, GPR35, GRIN2B, HTR2A, HTR2B, HTR2C, KCNH2, PIK3CB, SMAD3, TRPV1 |
4.38041 |
|
[BP] GO:0030155 |
regulation of cell adhesion
|
ALOX12, ALOX15, BCL2, CDK6, CYP1B1, DUSP3, GSK3B, IDO1, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, SMAD3, SRC, TEK |
4.38041 |
|
[BP] GO:0009895 |
negative regulation of catabolic process
|
ADORA1, ADRA2A, BCL2, CNR1, EGFR, HCAR2, HTR2B, MET, PIK3CA, PPARA, SMAD3 |
4.36687 |
|
[BP] GO:0043406 |
positive regulation of MAP kinase activity
|
ADORA1, ADRA2A, EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, PIK3CB, PTPN1, SRC |
4.35215 |
|
[BP] GO:0050789 |
regulation of biological process
|
ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1C3, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIN2B, GSK3B, HCAR2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, XDH |
4.34542 |
|
[BP] GO:1901617 |
organic hydroxy compound biosynthetic process
|
AKR1B1, AKR1C3, ALOX12, ALOX15, CES1, CYP19A1, CYP3A4, DHFR, TYR |
4.33795 |
|
[BP] GO:0051338 |
regulation of transferase activity
|
ADORA1, ADRA2A, APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, GSK3B, HTR2A, HTR2B, IGF1R, INSR, KIT, PIK3CA, PIK3CB, PTPN1, SRC, TEK, TNKS |
4.30587 |
|
[BP] GO:0050793 |
regulation of developmental process
|
ALOX12, APP, AXL, BCL2, CA2, CDK6, CNR1, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, GSK3B, HTR2A, HTR2C, IDO1, INSR, KDR, KIT, NUAK1, PIK3CA, PIM1, PPARA, PRKCA, PTGS2, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS2, TRPV1, XDH |
4.29016 |
|
[BP] GO:0043065 |
positive regulation of apoptotic process
|
AKR1C3, BCL2, CNR1, CYP1B1, F3, GSK3B, HCAR2, IDO1, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH |
4.25475 |
|
[BP] GO:0031401 |
positive regulation of protein modification process
|
ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH |
4.24842 |
|
[BP] GO:0043269 |
regulation of ion transport
|
ADORA1, ADRA2A, APP, BCL2, CA2, CA7, CHRM1, CNR1, GPR35, HTR1A, HTR1B, HTR2A, KCNH2, MMP9, PTGS2, SLC6A4 |
4.24842 |
|
[BP] GO:0071417 |
cellular response to organonitrogen compound
|
AKR1B1, APEX1, APP, EGFR, GSK3B, HTR1B, IGF1R, INSR, MMP2, PTGS2, SLC6A4, SRC, TRPV1 |
4.24815 |
|
[BP] GO:0050890 |
None
|
ADORA1, APP, CHRM1, CNR1, EGFR, GRIN2B, HTR2A, INSR, KIT, PTGS2, SLC6A4 |
4.2413 |
|
[BP] GO:0043068 |
positive regulation of programmed cell death
|
AKR1C3, BCL2, CNR1, CYP1B1, F3, GSK3B, HCAR2, IDO1, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH |
4.2093 |
|
[BP] GO:0032847 |
regulation of cellular pH reduction
|
BCL2, CA2, CA7 |
4.19841 |
|
[BP] GO:0009056 |
catabolic process
|
ACHE, ADORA1, AKR1B10, AKR1C3, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, GBA2, GSK3B, HSPA1A, IDO1, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH |
4.1593 |
|
[BP] GO:0032768 |
None
|
CNR1, CNR2, DHFR, EGFR, HTR2B, TERT |
4.15319 |
|
[BP] GO:0032101 |
regulation of response to external stimulus
|
ADORA1, ALOX12, CNR1, CNR2, CYP19A1, EGFR, ESR1, F3, FABP4, IDO1, KDR, MET, MMP12, PPARA, PRKCA, PTGS2, SMAD3, TEK |
4.12573 |
|
[BP] GO:0046686 |
response to cadmium ion
|
AKR1C3, CYP1A2, EGFR, KIT, MMP9, TERT |
4.10907 |
|
[BP] GO:0000302 |
response to reactive oxygen species
|
AKR1B1, AKR1C3, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC |
4.10522 |
|
[BP] GO:0051098 |
regulation of binding
|
APP, AURKB, BCL2, CYP2D6, GSK3B, MET, MMP9, PPARA, SMAD3, SRC, TERT, TNKS |
4.10373 |
|
[BP] GO:0080090 |
regulation of primary metabolic process
|
ADORA1, ADORA3, ADRA2A, AKR1C3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GSK3B, HCAR2, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
4.10373 |
|
[BP] GO:0014065 |
phosphatidylinositol 3-kinase signaling
|
HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB |
4.10373 |
|
[BP] GO:0032846 |
positive regulation of homeostatic process
|
AURKB, CA2, CA7, CNR1, EGFR, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 |
4.10051 |
|
[BP] GO:1904018 |
positive regulation of vasculature development
|
ALOX12, CYP1B1, F3, KDR, KIT, PRKCA, PTGS2, TEK, TERT |
4.09468 |
|
[BP] GO:0030522 |
intracellular receptor signaling pathway
|
ESR1, ESR2, ESRRA, ESRRB, NR3C1, PIM1, PPARA, RORC, SRC |
4.09468 |
|
[BP] GO:2000379 |
positive regulation of reactive oxygen species metabolic process
|
AKR1C3, EGFR, INSR, PTGS2, SMAD3, TRPV1, XDH |
4.07676 |
|
[BP] GO:0043401 |
steroid hormone mediated signaling pathway
|
ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC |
4.07486 |
|
[BP] GO:0018193 |
peptidyl-amino acid modification
|
AURKB, AXL, BCL2, CSNK2A1, EGFR, F10, FLT3, GSK3B, IGF1R, INSR, KDR, KIT, MET, PRKCA, SRC, TEK, TNKS, TOP1, TOP2A |
4.06856 |
|
[BP] GO:0031323 |
regulation of cellular metabolic process
|
ACHE, ADORA1, ADORA3, ADRA2A, AKR1C3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1B1, CYP2D6, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GSK3B, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
4.03286 |
|
[BP] GO:0009611 |
response to wounding
|
ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DHFR, EGFR, PPARA, SMAD3 |
4.02152 |
|
[BP] GO:0051966 |
regulation of synaptic transmission, glutamatergic
|
ADORA1, CNR1, EGFR, HTR1B, HTR2A, PTGS2 |
3.9948 |
|
[BP] GO:0022414 |
reproductive process
|
AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, IDO1, INSR, KIT, MMP2, MMP9, PTGS2, SLC6A4, SRC, TOP2A |
3.98595 |
|
[BP] GO:0010863 |
positive regulation of phospholipase C activity
|
EGFR, ESR1, HTR2A, HTR2B, KIT |
3.98136 |
|
[BP] GO:0098771 |
inorganic ion homeostasis
|
APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, GPR35, GRIN2B, HTR2A, HTR2B, HTR2C, KCNH2, PIK3CB, SMAD3, TRPV1 |
3.98074 |
|
[BP] GO:0031399 |
regulation of protein modification process
|
ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TEK, XDH |
3.97878 |
|
[BP] GO:0090087 |
None
|
ACHE, ADORA1, ADRA2A, APP, CA2, CHRM1, CNR1, EGFR, GSK3B, HCAR2, HTR2B, HTR2C, MMP12, PRKCA, PTGS2, PTPN1, SMAD3, SRC |
3.93708 |
|
[BP] GO:1901699 |
cellular response to nitrogen compound
|
AKR1B1, APEX1, APP, EGFR, GSK3B, HTR1B, IGF1R, INSR, MMP2, PTGS2, SLC6A4, SRC, TRPV1 |
3.91059 |
|
[BP] GO:0051046 |
None
|
ACHE, ADORA1, ADRA2A, CNR1, CYP19A1, EGFR, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, PRKCA, SLC6A4, SRC, TRPV1 |
3.90114 |
|
[BP] GO:0009991 |
response to extracellular stimulus
|
AKR1C3, ALPL, AXL, BCL2, CNR1, CYP1A1, EGFR, HSD11B2, PTGS2, SLC6A4, SRC, TRPV1, TYR |
3.86873 |
|
[BP] GO:0010810 |
regulation of cell-substrate adhesion
|
ALOX15, BCL2, CDK6, GSK3B, KDR, PIK3CB, SMAD3, SRC, TEK |
3.8657 |
|
[BP] GO:0007197 |
None
|
CHRM1, CHRM2, CHRM4 |
3.8547 |
|
[BP] GO:0071502 |
None
|
HTR1B, HTR2B, TRPV1 |
3.8547 |
|
[BP] GO:0010513 |
None
|
HTR2A, HTR2B, HTR2C |
3.8547 |
|
[BP] GO:0071071 |
None
|
FABP3, HTR2A, HTR2B, HTR2C |
3.85045 |
|
[BP] GO:0019372 |
lipoxygenase pathway
|
ALOX12, ALOX15, ALOX5, PTGS2 |
3.85045 |
|
[BP] GO:1900274 |
regulation of phospholipase C activity
|
EGFR, ESR1, HTR2A, HTR2B, KIT |
3.81378 |
|
[BP] GO:0044283 |
None
|
AKR1B1, AKR1C3, ALOX12, ALOX15, ALOX5, CES1, CYP19A1, CYP1A1, CYP3A4, DHFR, IDO1, PTGS1, PTGS2 |
3.80525 |
|
[BP] GO:0045787 |
positive regulation of cell cycle
|
APEX1, APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, PRKCA, SLC6A4, SRC, TERT |
3.80027 |
|
[BP] GO:0007584 |
response to nutrient
|
AKR1C3, ALPL, CNR1, CYP1A1, EGFR, PTGS2, SLC6A4, TRPV1, TYR |
3.78632 |
|
[BP] GO:0045931 |
positive regulation of mitotic cell cycle
|
APEX1, APP, CDC25B, CYP1A1, DUSP3, INSR, PRKCA, TERT |
3.7826 |
|
[BP] GO:0006940 |
None
|
ADORA1, ADRA2A, CHRM1, CHRM2, KIT, PTGS2 |
3.7808 |
|
[BP] GO:0034599 |
cellular response to oxidative stress
|
AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC |
3.77175 |
|
[BP] GO:0046456 |
icosanoid biosynthetic process
|
ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 |
3.76192 |
|
[BP] GO:0071248 |
cellular response to metal ion
|
AKR1C3, ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 |
3.69884 |
|
[BP] GO:0043549 |
regulation of kinase activity
|
ADORA1, ADRA2A, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KIT, PIK3CA, PIK3CB, PTPN1, SRC, TEK |
3.6947 |
|
[BP] GO:1903530 |
regulation of secretion by cell
|
ACHE, ADORA1, ADRA2A, CNR1, CYP19A1, EGFR, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, PRKCA, SLC6A4, SRC |
3.68177 |
|
[BP] GO:0051347 |
positive regulation of transferase activity
|
ADORA1, ADRA2A, AURKB, CDC25B, EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, PIK3CA, PIK3CB, PTPN1, SRC, TEK, TNKS |
3.65955 |
|
[BP] GO:0035556 |
intracellular signal transduction
|
ADRA2A, AKR1B1, AXL, BCL2, CYP1B1, EGFR, GRIN2B, GSK3B, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KCNH2, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, POLB, PRKCA, PTPN1, SRC, TEK |
3.65955 |
|
[BP] GO:0002682 |
regulation of immune system process
|
ADORA1, ALOX15, APP, AXL, BCL2, CA2, CDK6, CNR1, CNR2, CYP19A1, DUSP3, ESR1, ESRRA, HCAR2, HSPA1A, IDO1, KIT, MMP12, MMP2, PIK3CA, PIK3CB, PRKCA, PTPN1, SMAD3, SRC |
3.65578 |
|
[BP] GO:0016137 |
None
|
AKR1B1, AKR1B10, AKR1C3, GBA2 |
3.64952 |
|
[BP] GO:0042180 |
None
|
AKR1B1, AKR1B10, AKR1C3, CYP19A1, GLO1, IDO1 |
3.64028 |
|
[BP] GO:0007166 |
cell surface receptor signaling pathway
|
ADORA1, ADORA3, APP, AXL, BCL2, CA1, CHRM4, CSNK2A1, EGFR, F3, FLT3, GPR35, GRIN2B, GSK3B, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 |
3.61951 |
|
[BP] GO:0050727 |
regulation of inflammatory response
|
ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, IDO1, PPARA, PTGS2, SMAD3, TEK |
3.61951 |
|
[BP] GO:0001101 |
response to acid chemical
|
AKR1B1, AKR1C3, DHFR, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SLC6A4, SRC |
3.6167 |
|
[BP] GO:0043393 |
regulation of protein binding
|
APP, AURKB, BCL2, GSK3B, MET, MMP9, PPARA, SRC, TERT |
3.59331 |
|
[BP] GO:0007207 |
None
|
CHRM1, CHRM2, CHRM4 |
3.5905 |
|
[BP] GO:0032229 |
None
|
ADORA1, CNR2, HTR1B |
3.5905 |
|
[BP] GO:2001300 |
lipoxin metabolic process
|
ALOX12, ALOX15, ALOX5 |
3.5905 |
|
[BP] GO:0045766 |
positive regulation of angiogenesis
|
ALOX12, CYP1B1, F3, KDR, PRKCA, PTGS2, TEK, TERT |
3.5905 |
|
[BP] GO:0046883 |
regulation of hormone secretion
|
ADORA1, ADRA2A, CNR1, CYP19A1, EGFR, HCAR2, HTR1A, HTR2A, HTR2C, PRKCA |
3.58453 |
|
[BP] GO:0031329 |
regulation of cellular catabolic process
|
ADRA2A, APEX1, BCL2, CNR1, ESRRB, GSK3B, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PTPN1 |
3.56422 |
|
[BP] GO:1904407 |
positive regulation of nitric oxide metabolic process
|
EGFR, INSR, PTGS2, SMAD3, TRPV1 |
3.56116 |
|
[BP] GO:0045429 |
positive regulation of nitric oxide biosynthetic process
|
EGFR, INSR, PTGS2, SMAD3, TRPV1 |
3.56116 |
|
[BP] GO:0031347 |
regulation of defense response
|
ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, IDO1, MMP12, MMP2, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK |
3.53859 |
|
[BP] GO:0045859 |
regulation of protein kinase activity
|
ADORA1, ADRA2A, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KIT, PIK3CA, PIK3CB, PTPN1, SRC |
3.52523 |
|
[BP] GO:0051701 |
interaction with host
|
AXL, EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC |
3.51648 |
|
[BP] GO:0033674 |
positive regulation of kinase activity
|
ADORA1, ADRA2A, CDC25B, EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, PIK3CA, PIK3CB, PTPN1, SRC, TEK |
3.49797 |
|
[BP] GO:0016042 |
lipid catabolic process
|
ADORA1, AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 |
3.49337 |
|
[BP] GO:0055080 |
cation homeostasis
|
APP, BCL2, CA2, CA7, EGFR, ESR1, GPR35, GRIN2B, HTR2A, HTR2B, HTR2C, KCNH2, PIK3CB, SMAD3, TRPV1 |
3.48527 |
|
[BP] GO:0051094 |
positive regulation of developmental process
|
ALOX12, APP, AXL, BCL2, CA2, CNR1, CYP1B1, ESRRB, F3, HTR2A, HTR2C, IDO1, INSR, KDR, KIT, PIM1, PRKCA, PTGS2, SMAD3, SRC, TEK, TERT |
3.47838 |
|
[BP] GO:0001503 |
ossification
|
ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK |
3.47073 |
|
[BP] GO:0051726 |
regulation of cell cycle
|
APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, PTGS2, SLC6A4, SMAD3, SRC, TERT, TNKS, TOP2A |
3.46761 |
|
[BP] GO:0031667 |
response to nutrient levels
|
AKR1C3, ALPL, BCL2, CNR1, CYP1A1, EGFR, HSD11B2, PTGS2, SLC6A4, SRC, TRPV1, TYR |
3.45539 |
|
[BP] GO:0051130 |
positive regulation of cellular component organization
|
ALOX15, APP, AURKB, AXL, BCL2, CNR1, ESR1, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 |
3.44376 |
|
[BP] GO:0019373 |
epoxygenase P450 pathway
|
CYP1A1, CYP1A2, CYP1B1, CYP2C19 |
3.39937 |
|
[BP] GO:0032103 |
positive regulation of response to external stimulus
|
CNR1, EGFR, F3, FABP4, IDO1, KDR, MET, PRKCA, PTGS2, SMAD3 |
3.38286 |
|
[BP] GO:0048871 |
multicellular organismal homeostasis
|
ADORA1, AKR1B1, ALOX12, HTR2A, MET, PIK3CA, TRPV1 |
3.38286 |
|
[BP] GO:0009891 |
positive regulation of biosynthetic process
|
APP, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PPARA, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1 |
3.38286 |
|
[BP] GO:0001954 |
positive regulation of cell-matrix adhesion
|
CDK6, GSK3B, KDR, SMAD3, TEK |
3.38216 |
|
[BP] GO:0040016 |
embryonic cleavage
|
PIK3CB, TOP1, TOP2A |
3.38216 |
|
[BP] GO:0009820 |
alkaloid metabolic process
|
CYP1A2, CYP2D6, CYP3A4 |
3.38216 |
|
[BP] GO:0014062 |
None
|
HTR1A, HTR1B, SLC6A4 |
3.38216 |
|
[BP] GO:0010511 |
None
|
HTR2A, HTR2B, HTR2C |
3.38216 |
|
[BP] GO:0009755 |
hormone-mediated signaling pathway
|
ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC |
3.36483 |
|
[BP] GO:0072507 |
divalent inorganic cation homeostasis
|
APP, BCL2, EGFR, ESR1, GPR35, GRIN2B, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3, TRPV1 |
3.3364 |
|
[BP] GO:1904707 |
positive regulation of vascular smooth muscle cell proliferation
|
HTR1B, MMP2, MMP9, TERT |
3.33024 |
|
[BP] GO:0050995 |
None
|
ADORA1, ADRA2A, CNR1, HCAR2 |
3.33024 |
|
[BP] GO:0009605 |
response to external stimulus
|
ADORA1, AKR1C3, ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, EGFR, HSD11B2, HTR2A, IDO1, KIT, MMP12, PTGS2, SLC6A4, SMAD3, SRC, TRPV1, TYR |
3.31154 |
|
[BP] GO:0071902 |
positive regulation of protein serine/threonine kinase activity
|
ADORA1, ADRA2A, EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, PIK3CB, PTPN1, SRC |
3.30996 |
|
[BP] GO:0051051 |
negative regulation of transport
|
ADORA1, ADRA2A, APP, BCL2, CNR1, GPR35, GSK3B, HSPA1A, HTR1B, HTR2A, KCNH2, MMP9, PTGS2 |
3.30221 |
|
[BP] GO:0038083 |
peptidyl-tyrosine autophosphorylation
|
EGFR, IGF1R, INSR, KDR, SRC |
3.30082 |
|
[BP] GO:0071241 |
cellular response to inorganic substance
|
AKR1C3, ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 |
3.28103 |
|
[BP] GO:0032355 |
response to estradiol
|
CYP1A2, EGFR, ESR1, ESRRA, HTR5A, PTGS2, SLC6A4 |
3.26184 |
|
[BP] GO:0006939 |
None
|
HTR1D, HTR2A, HTR2B, HTR7, TRPV1 |
3.25955 |
|
[BP] GO:0071900 |
regulation of protein serine/threonine kinase activity
|
ADORA1, ADRA2A, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, KIT, PIK3CB, PTPN1, SRC |
3.24508 |
|
[BP] GO:0010634 |
positive regulation of epithelial cell migration
|
KDR, MET, MMP9, PRKCA, PTGS2, SRC, TEK |
3.24334 |
|
[BP] GO:0050730 |
None
|
ADORA1, ADRA2A, APP, EGFR, FLT3, HTR2A, KIT, PTPN1, SRC |
3.2332 |
|
[BP] GO:0007568 |
aging
|
APEX1, AURKB, BCL2, CNR1, CYP1A1, HTR2A, POLB, PTGS2, TERT |
3.2332 |
|
[BP] GO:0010518 |
positive regulation of phospholipase activity
|
EGFR, ESR1, HTR2A, HTR2B, KIT |
3.22251 |
|
[BP] GO:0044597 |
None
|
AKR1B1, AKR1B10, AKR1C3 |
3.20648 |
|
[BP] GO:0044598 |
None
|
AKR1B1, AKR1B10, AKR1C3 |
3.20648 |
|
[BP] GO:0030638 |
None
|
AKR1B1, AKR1B10, AKR1C3 |
3.20648 |
|
[BP] GO:0008150 |
biological_process
|
ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, GRIN2B, GSK3B, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TYR, XDH |
3.19742 |
|
[BP] GO:0008210 |
estrogen metabolic process
|
CYP19A1, CYP1B1, HSD17B1, HSD17B2 |
3.194 |
|
[BP] GO:0006954 |
inflammatory response
|
ADORA1, ADORA3, ALOX15, AXL, CNR2, KIT, PIK3CA, PIK3CB, POLB, PTGS1, PTGS2, TRPV1 |
3.18812 |
|
[BP] GO:0048660 |
regulation of smooth muscle cell proliferation
|
AKR1B1, EGFR, HTR1B, MMP2, MMP9, PTGS2, TERT |
3.18773 |
|
[BP] GO:0007611 |
None
|
APP, CNR1, EGFR, GRIN2B, HTR2A, INSR, KIT, PTGS2, SLC6A4 |
3.18323 |
|
[BP] GO:0051171 |
regulation of nitrogen compound metabolic process
|
ADORA1, ADORA3, ADRA2A, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GSK3B, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
3.18164 |
|
[BP] GO:0045860 |
positive regulation of protein kinase activity
|
ADORA1, ADRA2A, CDC25B, EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, PIK3CA, PIK3CB, PTPN1, SRC |
3.16226 |
|
[BP] GO:0046683 |
response to organophosphorus
|
APEX1, APP, PTGS2, SLC6A4, TEK, TRPV1, TYR |
3.14902 |
|
[BP] GO:0003006 |
developmental process involved in reproduction
|
AKR1C3, ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, KIT, PTGS2, SRC |
3.1128 |
|
[BP] GO:1903428 |
positive regulation of reactive oxygen species biosynthetic process
|
EGFR, INSR, PTGS2, SMAD3, TRPV1 |
3.11017 |
|
[BP] GO:0050994 |
None
|
ADORA1, ADRA2A, CNR1, HCAR2, PPARA |
3.11017 |
|
[BP] GO:0051341 |
None
|
CNR1, CNR2, DHFR, EGFR, HTR2B, TERT |
3.10898 |
|
[BP] GO:0060255 |
regulation of macromolecule metabolic process
|
ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, GSK3B, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, XDH |
3.10898 |
|
[BP] GO:0031328 |
positive regulation of cellular biosynthetic process
|
APP, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, MET, MMP12, NR3C1, PPARA, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1 |
3.07736 |
|
[BP] GO:0006693 |
None
|
AKR1C3, CES2, PTGS1, PTGS2 |
3.06547 |
|
[BP] GO:0006692 |
None
|
AKR1C3, CES2, PTGS1, PTGS2 |
3.06547 |
|
[BP] GO:0001775 |
cell activation
|
ADRA2A, ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, RORC, SMAD3, SRC, TRPV1 |
3.0625 |
|
[BP] GO:0030647 |
None
|
AKR1B1, AKR1B10, AKR1C3 |
3.05425 |
|
[BP] GO:0033555 |
multicellular organismal response to stress
|
BCL2, HTR1A, HTR2C, IDO1, SLC6A2 |
3.03939 |
|
[BP] GO:0007623 |
circadian rhythm
|
EGFR, GSK3B, HTR7, PPARA, RORC, SLC6A4, TOP1 |
3.03613 |
|
[BP] GO:0032268 |
regulation of cellular protein metabolic process
|
ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GSK3B, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
3.03613 |
|
[BP] GO:0006874 |
cellular calcium ion homeostasis
|
APP, BCL2, ESR1, GPR35, GRIN2B, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3, TRPV1 |
3.0215 |
|
[BP] GO:0019725 |
cellular homeostasis
|
APEX1, APP, BCL2, CA2, CA7, ESR1, GPR35, GRIN2B, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, POLA1, SMAD3, TRPV1 |
3.00817 |
|
[BP] GO:0010638 |
positive regulation of organelle organization
|
ALOX15, AURKB, BCL2, GSK3B, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 |
3.00417 |
|
[BP] GO:0051384 |
response to glucocorticoid
|
ALPL, BCL2, EGFR, FLT3, HSD11B2, NR3C1, PTGS2 |
2.98058 |
|
[BP] GO:0006464 |
cellular protein modification process
|
ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GRIN2B, GSK3B, HTR2B, IGF1R, INSR, KCNH2, KDR, KIT, MET, NUAK1, PIK3CA, PIM1, POLB, PRKCA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A |
2.9719 |
|
[BP] GO:0036211 |
protein modification process
|
ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GRIN2B, GSK3B, HTR2B, IGF1R, INSR, KCNH2, KDR, KIT, MET, NUAK1, PIK3CA, PIM1, POLB, PRKCA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A |
2.9719 |
|
[BP] GO:2001243 |
negative regulation of intrinsic apoptotic signaling pathway
|
BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC |
2.93862 |
|
[BP] GO:0097553 |
None
|
GRIN2B, HTR2A, HTR2B, HTR2C, TRPV1 |
2.93675 |
|
[BP] GO:0045428 |
regulation of nitric oxide biosynthetic process
|
EGFR, INSR, PTGS2, SMAD3, TRPV1 |
2.93675 |
|
[BP] GO:0055065 |
metal ion homeostasis
|
APP, BCL2, EGFR, ESR1, GPR35, GRIN2B, HTR2A, HTR2B, HTR2C, KCNH2, PIK3CB, SMAD3, TRPV1 |
2.9241 |
|
[BP] GO:0010906 |
None
|
ESRRB, GSK3B, INSR, PPARA, RORC, SRC |
2.91665 |
|
[BP] GO:0055074 |
calcium ion homeostasis
|
APP, BCL2, ESR1, GPR35, GRIN2B, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3, TRPV1 |
2.91046 |
|
[BP] GO:0006636 |
unsaturated fatty acid biosynthetic process
|
ALOX12, ALOX15, PTGS1, PTGS2 |
2.89254 |
|
[BP] GO:0034502 |
protein localization to chromosome
|
AURKB, ESR1, TERT, TNKS, TNKS2 |
2.87015 |
|
[BP] GO:0010517 |
regulation of phospholipase activity
|
EGFR, ESR1, HTR2A, HTR2B, KIT |
2.87015 |
|
[BP] GO:0070988 |
demethylation
|
APEX1, CYP1A1, CYP1A2, CYP2D6, CYP3A4 |
2.87015 |
|
[BP] GO:0072503 |
cellular divalent inorganic cation homeostasis
|
APP, BCL2, ESR1, GPR35, GRIN2B, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3, TRPV1 |
2.86504 |
|
[BP] GO:0014074 |
response to purine-containing compound
|
APEX1, APP, PTGS2, SLC6A4, TEK, TRPV1, TYR |
2.85866 |
|
[BP] GO:0042391 |
None
|
ADORA1, APP, BCL2, CNR1, CNR2, GPR35, GRIN2B, KCNH2, KDR, SRC, TRPV1 |
2.84804 |
|
[BP] GO:0048869 |
cellular developmental process
|
ACHE, AKR1C3, ALPL, APP, AXL, BCL2, CBR1, CDC25B, CDK6, CES1, CYP1A1, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, GSK3B, HTR2B, KDR, KIT, MET, MMP2, MMP9, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TOP2A |
2.84498 |
|
[BP] GO:0043552 |
positive regulation of phosphatidylinositol 3-kinase activity
|
FLT3, KIT, SRC, TEK |
2.84118 |
|
[BP] GO:0019229 |
None
|
ADRA2A, CHRM1, EGFR, HTR2A, PTGS2 |
2.84118 |
|
[BP] GO:0050678 |
None
|
CDK6, EGFR, F3, HTR2B, KDR, MMP12, PRKCA, SMAD3, TEK, XDH |
2.83691 |
|
[BP] GO:1901342 |
regulation of vasculature development
|
ALOX12, CYP1B1, F3, KDR, KIT, PRKCA, PTGS2, TEK, TERT, XDH |
2.82671 |
|
[BP] GO:0048015 |
phosphatidylinositol-mediated signaling
|
HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB |
2.81158 |
|
[BP] GO:0008217 |
None
|
ADORA1, CNR1, HSD11B2, PPARA, PTGS1, PTGS2, SMAD3 |
2.81158 |
|
[BP] GO:0051828 |
entry into other organism involved in symbiotic interaction
|
AXL, EGFR, HSPA1A, HTR2A, MET, SRC |
2.81158 |
|
[BP] GO:0030260 |
entry into host cell
|
AXL, EGFR, HSPA1A, HTR2A, MET, SRC |
2.81158 |
|
[BP] GO:0051806 |
entry into cell of other organism involved in symbiotic interaction
|
AXL, EGFR, HSPA1A, HTR2A, MET, SRC |
2.81158 |
|
[BP] GO:0044409 |
entry into host
|
AXL, EGFR, HSPA1A, HTR2A, MET, SRC |
2.81158 |
|
[BP] GO:0002320 |
lymphoid progenitor cell differentiation
|
BCL2, FLT3, KIT |
2.80197 |
|
[BP] GO:0009266 |
None
|
ADORA1, HSPA1A, HTR1B, HTR2A, HTR2B, PTGS2, TRPV1 |
2.79757 |
|
[BP] GO:0071276 |
cellular response to cadmium ion
|
AKR1C3, CYP1A2, EGFR, MMP9 |
2.79712 |
|
[BP] GO:0033554 |
cellular response to stress
|
AKR1B1, AKR1C3, ALOX15, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, DHFR, EGFR, GSK3B, HSPA1A, MMP9, NUAK1, POLA1, POLB, PTGS2, PTPN1, SRC, TERT, TOP2A, TRPV1 |
2.79712 |
|
[BP] GO:0070201 |
None
|
ACHE, ADRA2A, APP, BCL2, CHRM1, CNR1, EGFR, GSK3B, HCAR2, HTR2B, MMP12, PRKCA, PTGS2, PTPN1, SMAD3, SRC |
2.79712 |
|
[BP] GO:0072593 |
reactive oxygen species metabolic process
|
ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR |
2.79712 |
|
[BP] GO:0060193 |
positive regulation of lipase activity
|
EGFR, ESR1, HTR2A, HTR2B, KIT |
2.79712 |
|
[BP] GO:0080135 |
regulation of cellular response to stress
|
APP, CDK6, DHFR, DUSP3, EGFR, GSK3B, HSPA1A, IGF1R, MET, NUAK1, PTGS2, PTPN1, TERT, XDH |
2.79712 |
|
[BP] GO:0007208 |
None
|
HTR2A, HTR2C |
2.79712 |
|
[BP] GO:0016488 |
None
|
AKR1B10, AKR1C3 |
2.79712 |
|
[BP] GO:0016487 |
None
|
AKR1B10, AKR1C3 |
2.79712 |
|
[BP] GO:0016107 |
None
|
AKR1B10, AKR1C3 |
2.79712 |
|
[BP] GO:0009115 |
None
|
AOX1, XDH |
2.79712 |
|
[BP] GO:0006714 |
None
|
AKR1B10, AKR1C3 |
2.79712 |
|
[BP] GO:0006286 |
base-excision repair, base-free sugar-phosphate removal
|
APEX1, POLB |
2.79712 |
|
[BP] GO:2001301 |
lipoxin biosynthetic process
|
ALOX12, ALOX15 |
2.79712 |
|
[BP] GO:2001302 |
lipoxin A4 metabolic process
|
ALOX12, ALOX15 |
2.79712 |
|
[BP] GO:2001303 |
lipoxin A4 biosynthetic process
|
ALOX12, ALOX15 |
2.79712 |
|
[BP] GO:0044089 |
positive regulation of cellular component biogenesis
|
ALOX15, ESR1, GSK3B, HSPA1A, KDR, KIT, MET, MMP1, PRKCA, SMAD3, SRC, TEK |
2.79302 |
|
[BP] GO:0030003 |
cellular cation homeostasis
|
APP, BCL2, CA2, CA7, ESR1, GPR35, GRIN2B, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3, TRPV1 |
2.79188 |
|
[BP] GO:0048608 |
reproductive structure development
|
AKR1C3, AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, KIT, SRC |
2.78587 |
|
[BP] GO:0043412 |
macromolecule modification
|
ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GRIN2B, GSK3B, HTR2B, IGF1R, INSR, KCNH2, KDR, KIT, MET, NR3C1, NUAK1, PIK3CA, PIM1, POLB, PRKCA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A |
2.77596 |
|
[BP] GO:0055082 |
cellular chemical homeostasis
|
APP, BCL2, CA2, CA7, ESR1, GPR35, GRIN2B, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, SMAD3, TRPV1 |
2.77557 |
|
[BP] GO:0016477 |
cell migration
|
AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK |
2.75061 |
|
[BP] GO:0046889 |
None
|
FABP3, HTR2A, HTR2B, HTR2C, PTGS2 |
2.74388 |
|
[BP] GO:0060402 |
None
|
GRIN2B, HTR2A, HTR2B, HTR2C, TRPV1 |
2.74388 |
|
[BP] GO:0048017 |
inositol lipid-mediated signaling
|
HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB |
2.74388 |
|
[BP] GO:0032880 |
regulation of protein localization
|
ACHE, ADRA2A, APP, BCL2, CHRM1, CNR1, CSNK2A1, EGFR, GSK3B, HCAR2, HTR2B, MMP12, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TERT |
2.73626 |
|
[BP] GO:0032870 |
cellular response to hormone stimulus
|
ADRA2A, AKR1C3, APEX1, EGFR, ESR1, FLT3, INSR, KIT, NR3C1, SRC |
2.73515 |
|
[BP] GO:0044236 |
multicellular organism metabolic process
|
AKR1C3, MMP1, MMP12, MMP2, MMP9, TRPV1 |
2.72795 |
|
[BP] GO:0010811 |
positive regulation of cell-substrate adhesion
|
ALOX15, CDK6, GSK3B, KDR, SMAD3, TEK |
2.72795 |
|
[BP] GO:0044267 |
cellular protein metabolic process
|
ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GRIN2B, GSK3B, HTR2B, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP1, MMP2, NUAK1, PIK3CA, PIM1, POLB, PRKCA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A |
2.72795 |
|
[BP] GO:0090218 |
positive regulation of lipid kinase activity
|
FLT3, KIT, SRC, TEK |
2.71938 |
|
[BP] GO:0010907 |
None
|
ESRRB, INSR, PPARA, SRC |
2.71938 |
|
[BP] GO:0042738 |
exogenous drug catabolic process
|
CYP1A2, CYP2C19, CYP3A4 |
2.71742 |
|
[BP] GO:0045759 |
None
|
CNR1, CNR2, GPR35 |
2.71742 |
|
[BP] GO:0070989 |
oxidative demethylation
|
CYP1A2, CYP2D6, CYP3A4 |
2.71742 |
|
[BP] GO:0032496 |
response to lipopolysaccharide
|
ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, PTGS2, SRC |
2.71427 |
|
[BP] GO:0043434 |
None
|
APEX1, FABP3, HSD11B2, INSR, PPARA, PTGS2, SRC, TEK, TRPV1 |
2.703 |
|
[BP] GO:0006873 |
cellular ion homeostasis
|
APP, BCL2, CA2, CA7, ESR1, GPR35, GRIN2B, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3, TRPV1 |
2.70058 |
|
[BP] GO:0042542 |
response to hydrogen peroxide
|
AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC |
2.69196 |
|
[BP] GO:0008406 |
gonad development
|
AKR1C3, BCL2, CYP19A1, ESR1, INSR, KIT |
2.69196 |
|
[BP] GO:0006367 |
transcription initiation from RNA polymerase II promoter
|
ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC |
2.66235 |
|
[BP] GO:0030168 |
platelet activation
|
ADRA2A, AXL, PIK3CA, PIK3CB, PRKCA, SRC |
2.64893 |
|
[BP] GO:0045913 |
None
|
ESRRB, HTR2A, INSR, PPARA, SRC |
2.63263 |
|
[BP] GO:0022900 |
electron transport chain
|
AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, NQO2, XDH |
2.63067 |
|
[BP] GO:2000026 |
regulation of multicellular organismal development
|
ALOX12, APP, AXL, BCL2, CA2, CDK6, CNR1, CYP1B1, EGFR, ESR1, ESRRA, F3, GSK3B, IDO1, INSR, KDR, KIT, PIM1, PRKCA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, XDH |
2.62799 |
|
[BP] GO:1903522 |
None
|
ADORA1, ADORA3, ADRA2A, CHRM1, CHRM2, EGFR, HTR2A, KCNH2, PTGS2 |
2.62799 |
|
[BP] GO:0071396 |
cellular response to lipid
|
AKR1C3, AXL, CDK6, EGFR, ESR1, FLT3, NR3C1, RORC, SLC6A4, SRC |
2.61762 |
|
[BP] GO:0006703 |
estrogen biosynthetic process
|
CYP19A1, HSD17B1, HSD17B2 |
2.61721 |
|
[BP] GO:0018105 |
peptidyl-serine phosphorylation
|
AURKB, BCL2, GSK3B, PRKCA, SRC, TNKS, TOP1 |
2.58525 |
|
[BP] GO:1904951 |
positive regulation of establishment of protein localization
|
ACHE, APP, BCL2, CHRM1, EGFR, GSK3B, HCAR2, HTR2B, MMP12, PTGS2, SMAD3, SRC |
2.58078 |
|
[BP] GO:0019538 |
protein metabolic process
|
ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GRIN2B, GSK3B, HTR2B, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, POLB, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A |
2.55857 |
|
[BP] GO:0051172 |
None
|
ADRA2A, APEX1, APP, AURKB, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HSPA1A, HTR1B, HTR1E, IGF1R, MMP12, MMP9, NR3C1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1, XDH |
2.55654 |
|
[BP] GO:0048534 |
hematopoietic or lymphoid organ development
|
BCL2, FLT3, KDR, KIT, POLB, TEK, TYR |
2.55553 |
|
[BP] GO:1900543 |
None
|
ADRA2A, HTR1B, HTR1E, PPARA, PRKCA |
2.55264 |
|
[BP] GO:0050728 |
negative regulation of inflammatory response
|
ADORA1, CNR2, CYP19A1, PPARA, SMAD3, TEK |
2.55264 |
|
[BP] GO:0090257 |
None
|
ADORA1, ADRA2A, CHRM1, CHRM2, KIT, PRKCA, PTGS2, SMAD3 |
2.53644 |
|
[BP] GO:0051223 |
None
|
ACHE, ADRA2A, APP, CHRM1, CNR1, EGFR, GSK3B, HCAR2, HTR2B, MMP12, PRKCA, PTGS2, PTPN1, SMAD3, SRC |
2.53644 |
|
[BP] GO:0006928 |
movement of cell or subcellular component
|
ADRA2A, ALOX12, APP, AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, SRC, TEK |
2.52968 |
|
[BP] GO:0045980 |
None
|
ADRA2A, HTR1B, HTR1E, PPARA, PRKCA |
2.52799 |
|
[BP] GO:0048010 |
vascular endothelial growth factor receptor signaling pathway
|
AXL, KDR, PIK3CA, PIK3CB, SRC |
2.52799 |
|
[BP] GO:0060065 |
uterus development
|
CYP19A1, ESR1, SRC |
2.52671 |
|
[BP] GO:0051967 |
None
|
ADORA1, HTR1B, HTR2A |
2.52671 |
|
[BP] GO:0051704 |
multi-organism process
|
APP, AXL, BCL2, CDK6, CHRM2, CYP1A1, EGFR, HSD11B2, HSPA1A, HTR2A, IDO1, INSR, KDR, MET, MMP1, MMP12, POLA1, SLC6A4, SMAD3, SRC, TOP1 |
2.52481 |
|
[BP] GO:0002237 |
response to molecule of bacterial origin
|
ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, PTGS2, SRC |
2.51732 |
|
[BP] GO:0009896 |
positive regulation of catabolic process
|
ADRA2A, CSNK2A1, ESRRB, GSK3B, HSPA1A, HTR2A, INSR, KDR, PIK3CB, PPARA, PTPN1 |
2.50794 |
|
[BP] GO:0031348 |
negative regulation of defense response
|
ADORA1, CNR2, CYP19A1, MMP12, PPARA, SMAD3, TEK |
2.50139 |
|
[BP] GO:0071383 |
None
|
AKR1C3, EGFR, FLT3, NR3C1, SRC |
2.47899 |
|
[BP] GO:0008285 |
negative regulation of cell proliferation
|
ADORA1, ADORA3, APP, BCL2, CDK6, CYP1B1, FABP3, HSPA1A, IDO1, PTGS2, SLC6A4, SMAD3, TERT, XDH |
2.47568 |
|
[BP] GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation
|
ADORA1, ADRA2A, FLT3, HTR2A, KIT, PTPN1, SRC |
2.47527 |
|
[BP] GO:1900542 |
None
|
ADRA2A, ESRRB, HTR1B, HTR1E, HTR2A, INSR, PPARA, PRKCA |
2.47144 |
|
[BP] GO:0038128 |
None
|
EGFR, PIK3CA, PRKCA, SRC |
2.46616 |
|
[BP] GO:1904705 |
regulation of vascular smooth muscle cell proliferation
|
HTR1B, MMP2, MMP9, TERT |
2.46616 |
|
[BP] GO:0006109 |
regulation of carbohydrate metabolic process
|
ESRRB, GSK3B, HTR2A, INSR, PPARA, RORC, SRC |
2.46274 |
|
[BP] GO:0002791 |
None
|
ACHE, ADORA1, ADRA2A, CNR1, EGFR, HCAR2, HTR2B, HTR2C, MMP12, PRKCA, SRC |
2.45812 |
|
[BP] GO:0050806 |
positive regulation of synaptic transmission
|
ADORA1, APP, CA2, CA7, EGFR, PTGS2 |
2.45029 |
|
[BP] GO:0010675 |
None
|
ESRRB, GSK3B, INSR, PPARA, RORC, SRC |
2.45029 |
|
[BP] GO:0050679 |
None
|
EGFR, F3, HTR2B, KDR, MMP12, PRKCA, TEK |
2.45029 |
|
[BP] GO:0050965 |
None
|
ADORA1, HTR2A, TRPV1 |
2.44918 |
|
[BP] GO:0050961 |
None
|
ADORA1, HTR2A, TRPV1 |
2.44918 |
|
[BP] GO:0070198 |
None
|
TERT, TNKS, TNKS2 |
2.44918 |
|
[BP] GO:0051952 |
None
|
ADORA1, ADRA2A, CNR1, HTR1B, HTR2A |
2.4362 |
|
[BP] GO:0060401 |
None
|
GRIN2B, HTR2A, HTR2B, HTR2C, TRPV1 |
2.4362 |
|
[BP] GO:0043467 |
regulation of generation of precursor metabolites and energy
|
ESRRB, GSK3B, HTR2A, INSR, PIK3CA, PPARA |
2.4356 |
|
[BP] GO:0051047 |
None
|
ACHE, ADORA1, CYP19A1, EGFR, HCAR2, HTR2B, MMP12, SLC6A4, SRC, TRPV1 |
2.39865 |
|
[BP] GO:0006140 |
None
|
ADRA2A, ESRRB, HTR1B, HTR1E, HTR2A, INSR, PPARA, PRKCA |
2.39672 |
|
[BP] GO:0006807 |
nitrogen compound metabolic process
|
ACHE, AKR1B1, AKR1B10, AKR1C3, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FLT3, FUT7, GBA2, GLO1, GRIN2B, GSK3B, HSPA1A, HTR1A, HTR2B, HTR2C, IDO1, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH |
2.39672 |
|
[BP] GO:0018107 |
peptidyl-threonine phosphorylation
|
BCL2, CSNK2A1, GSK3B, PRKCA, TNKS |
2.39672 |
|
[BP] GO:0098502 |
DNA dephosphorylation
|
APEX1, POLB |
2.39672 |
|
[BP] GO:0009822 |
alkaloid catabolic process
|
CYP2D6, CYP3A4 |
2.39672 |
|
[BP] GO:0046110 |
None
|
AOX1, XDH |
2.39672 |
|
[BP] GO:0032849 |
positive regulation of cellular pH reduction
|
CA2, CA7 |
2.39672 |
|
[BP] GO:0032227 |
negative regulation of synaptic transmission, dopaminergic
|
PTGS2, SLC6A4 |
2.39672 |
|
[BP] GO:0016095 |
None
|
AKR1B10, AKR1C3 |
2.39672 |
|
[BP] GO:0048732 |
gland development
|
BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR |
2.3955 |
|
[BP] GO:0030258 |
lipid modification
|
ALOX12, CYP1A1, CYP3A4, EGFR, KIT, MET, PIK3CA, PIK3CB |
2.38387 |
|
[BP] GO:2000811 |
negative regulation of anoikis
|
BCL2, PIK3CA, SRC |
2.38217 |
|
[BP] GO:0007213 |
None
|
CHRM1, CHRM2, CHRM4 |
2.38217 |
|
[BP] GO:0030540 |
female genitalia development
|
AXL, CYP19A1, ESR1 |
2.38217 |
|
[BP] GO:0070920 |
None
|
EGFR, ESR1, TERT |
2.38217 |
|
[BP] GO:0045785 |
positive regulation of cell adhesion
|
ALOX12, ALOX15, CDK6, GSK3B, KDR, PIK3CA, PRKCA, SMAD3, SRC, TEK |
2.37049 |
|
[BP] GO:0045934 |
None
|
ADRA2A, APEX1, AURKB, ESR1, ESR2, ESRRA, FABP4, HSPA1A, HTR1B, HTR1E, MMP12, NR3C1, PPARA, PRKCA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1 |
2.36814 |
|
[BP] GO:0071363 |
cellular response to growth factor stimulus
|
APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 |
2.36447 |
|
[BP] GO:0032147 |
activation of protein kinase activity
|
ADORA1, ADRA2A, EGFR, INSR, KIT, PIK3CA, PIK3CB, PTPN1, SRC |
2.36252 |
|
[BP] GO:0051246 |
regulation of protein metabolic process
|
ADORA1, ADRA2A, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GSK3B, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
2.35957 |
|
[BP] GO:0045833 |
None
|
ADORA1, ADRA2A, AKR1C3, CNR1, HCAR2 |
2.355 |
|
[BP] GO:1901570 |
None
|
ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 |
2.355 |
|
[BP] GO:0048870 |
cell motility
|
AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK |
2.34828 |
|
[BP] GO:0018209 |
peptidyl-serine modification
|
AURKB, BCL2, GSK3B, PRKCA, SRC, TNKS, TOP1 |
2.34466 |
|
[BP] GO:0043551 |
regulation of phosphatidylinositol 3-kinase activity
|
FLT3, KIT, SRC, TEK |
2.3336 |
|
[BP] GO:0040011 |
locomotion
|
AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK |
2.31277 |
|
[BP] GO:1900182 |
positive regulation of protein localization to nucleus
|
APP, EGFR, PTGS2, SMAD3, SRC, TERT |
2.31277 |
|
[BP] GO:1904355 |
positive regulation of telomere capping
|
AURKB, TNKS, TNKS2 |
2.31212 |
|
[BP] GO:2000106 |
regulation of leukocyte apoptotic process
|
AURKB, AXL, HCAR2, IDO1, PIK3CB |
2.31212 |
|
[BP] GO:0033273 |
response to vitamin
|
ALPL, CYP1A1, EGFR, PTGS2, TYR |
2.31212 |
|
[BP] GO:1903426 |
None
|
EGFR, INSR, PTGS2, SMAD3, TRPV1 |
2.31212 |
|
[BP] GO:0031331 |
positive regulation of cellular catabolic process
|
ADRA2A, ESRRB, GSK3B, HSPA1A, HTR2A, INSR, KDR, PIK3CB, PPARA, PTPN1 |
2.31108 |
|
[BP] GO:0051128 |
regulation of cellular component organization
|
ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CNR1, CSNK2A1, EGFR, ESR1, ESR2, GRIN2B, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, PIK3CB, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A |
2.31091 |
|
[BP] GO:0001816 |
cytokine production
|
APP, FABP4, IDO1, KIT, PTGS2 |
2.28936 |
|
[BP] GO:1901989 |
None
|
APEX1, APP, CDC25B, CYP1A1, TERT |
2.26586 |
|
[BP] GO:0001936 |
None
|
F3, HTR2B, KDR, PRKCA, TEK, XDH |
2.26586 |
|
[BP] GO:0051209 |
None
|
HTR2A, HTR2B, HTR2C, TRPV1 |
2.26586 |
|
[BP] GO:0051283 |
None
|
HTR2A, HTR2B, HTR2C, TRPV1 |
2.26586 |
|
[BP] GO:0051222 |
positive regulation of protein transport
|
ACHE, APP, CHRM1, EGFR, GSK3B, HCAR2, HTR2B, MMP12, PTGS2, SMAD3, SRC |
2.26572 |
|
[BP] GO:0040008 |
regulation of growth
|
ALOX12, APP, BCL2, CSNK2A1, EGFR, ESR2, HSPA1A, INSR, PIK3CA, PIM1, SLC6A4, SMAD3, TNKS2 |
2.26468 |
|
[BP] GO:0001525 |
angiogenesis
|
CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PRKCA, PTGS2, TEK |
2.25213 |
|
[BP] GO:0018210 |
peptidyl-threonine modification
|
BCL2, CSNK2A1, GSK3B, PRKCA, TNKS |
2.24832 |
|
[BP] GO:0060191 |
regulation of lipase activity
|
EGFR, ESR1, HTR2A, HTR2B, KIT |
2.24832 |
|
[BP] GO:0010595 |
positive regulation of endothelial cell migration
|
KDR, MET, PRKCA, PTGS2, TEK |
2.24832 |
|
[BP] GO:0051000 |
None
|
DHFR, HTR2B, TERT |
2.24767 |
|
[BP] GO:0045821 |
None
|
ESRRB, HTR2A, INSR |
2.24767 |
|
[BP] GO:0009607 |
response to biotic stimulus
|
ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, GSK3B, IDO1, MMP12, PTGS2, SMAD3, SRC |
2.24552 |
|
[BP] GO:0046486 |
glycerolipid metabolic process
|
ACHE, ALOX15, CSNK2A1, EGFR, FABP3, FABP4, KIT, MET, PIK3CA, PIK3CB |
2.24439 |
|
[BP] GO:0006875 |
cellular metal ion homeostasis
|
APP, BCL2, ESR1, GPR35, GRIN2B, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3, TRPV1 |
2.24288 |
|
[BP] GO:0042136 |
neurotransmitter biosynthetic process
|
ACHE, CYP1B1, DHFR, SLC6A4 |
2.23819 |
|
[BP] GO:0044259 |
multicellular organismal macromolecule metabolic process
|
AKR1C3, MMP1, MMP12, MMP2, MMP9 |
2.23204 |
|
[BP] GO:0042058 |
None
|
ADORA1, ADRA2A, APP, EGFR, MMP9 |
2.23204 |
|
[BP] GO:0001938 |
None
|
F3, HTR2B, KDR, PRKCA, TEK |
2.23204 |
|
[BP] GO:0002683 |
negative regulation of immune system process
|
ADORA1, ALOX15, AXL, CDK6, CNR1, CNR2, CYP19A1, DUSP3, IDO1, MMP12 |
2.2319 |
|
[BP] GO:0031099 |
regeneration
|
AXL, BCL2, CSNK2A1, DHFR, EGFR, FLT3 |
2.22745 |
|
[BP] GO:0002521 |
leukocyte differentiation
|
AXL, BCL2, FLT3, FUT7, GLO1, KIT, MMP9, RORC |
2.20709 |
|
[BP] GO:0050433 |
None
|
ADRA2A, CNR1, HTR1B, HTR2A |
2.20709 |
|
[BP] GO:0042133 |
neurotransmitter metabolic process
|
ACHE, CYP1B1, DHFR, HTR1A, SLC6A4 |
2.18919 |
|
[BP] GO:0016048 |
None
|
ADORA1, HTR2A, TRPV1 |
2.18666 |
|
[BP] GO:0051900 |
regulation of mitochondrial depolarization
|
BCL2, KDR, SRC |
2.18666 |
|
[BP] GO:0051197 |
None
|
ESRRB, HTR2A, INSR |
2.18666 |
|
[BP] GO:0003012 |
None
|
ADORA1, HTR1D, HTR2A, HTR2B, HTR7, KCNH2, PIK3CA, TRPV1 |
2.17759 |
|
[BP] GO:0030815 |
None
|
ADRA2A, HTR1B, HTR1E, PRKCA |
2.17609 |
|
[BP] GO:0045595 |
regulation of cell differentiation
|
APP, AXL, BCL2, CA2, CDK6, CNR1, EGFR, ESRRA, ESRRB, GSK3B, HTR2A, HTR2C, KDR, KIT, PPARA, PRKCA, PTGS2, RORC, SLC6A4, SMAD3, TERT, TRPV1, XDH |
2.1686 |
|
[BP] GO:0046394 |
None
|
ALOX12, ALOX15, ALOX5, CYP1A1, DHFR, IDO1, PTGS1, PTGS2 |
2.15735 |
|
[BP] GO:0016053 |
None
|
ALOX12, ALOX15, ALOX5, CYP1A1, DHFR, IDO1, PTGS1, PTGS2 |
2.15021 |
|
[BP] GO:2000351 |
None
|
AKR1C3, KDR, TEK, TERT |
2.15021 |
|
[BP] GO:0033031 |
positive regulation of neutrophil apoptotic process
|
HCAR2, PIK3CB |
2.15021 |
|
[BP] GO:0070213 |
None
|
TNKS, TNKS2 |
2.15021 |
|
[BP] GO:0006145 |
None
|
AOX1, XDH |
2.15021 |
|
[BP] GO:0038171 |
None
|
CNR1, CNR2 |
2.15021 |
|
[BP] GO:0018894 |
dibenzo-p-dioxin metabolic process
|
CYP1A1, CYP1A2 |
2.15021 |
|
[BP] GO:0014827 |
None
|
HTR1D, HTR2B |
2.15021 |
|
[BP] GO:0015711 |
organic anion transport
|
CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 |
2.14827 |
|
[BP] GO:0030800 |
None
|
ADRA2A, HTR1B, HTR1E, PRKCA |
2.12027 |
|
[BP] GO:0045935 |
positive regulation of nucleobase-containing compound metabolic process
|
APP, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, HTR2A, IGF1R, INSR, MET, MMP12, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A |
2.11996 |
|
[BP] GO:0008584 |
None
|
AKR1C3, BCL2, ESR1, INSR, KIT |
2.11679 |
|
[BP] GO:0006352 |
DNA-templated transcription, initiation
|
ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC |
2.10273 |
|
[BP] GO:0043281 |
regulation of cysteine-type endopeptidase activity involved in apoptotic process
|
CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH |
2.0905 |
|
[BP] GO:0009968 |
negative regulation of signal transduction
|
ADRA2A, BCL2, DUSP3, EGFR, ESR1, ESR2, GSK3B, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH |
2.08531 |
|
[BP] GO:0071498 |
cellular response to fluid shear stress
|
CA2, PTGS2, SRC |
2.07159 |
|
[BP] GO:1901653 |
cellular response to peptide
|
AKR1B1, APEX1, APP, GSK3B, IGF1R, INSR, SRC |
2.06691 |
|
[BP] GO:0006066 |
None
|
AKR1B1, AKR1B10, AKR1C3, APP, CES1, CYP1B1, CYP3A4, DHFR |
2.06619 |
|
[BP] GO:0010676 |
None
|
ESRRB, INSR, PPARA, SRC |
2.06057 |
|
[BP] GO:0043550 |
regulation of lipid kinase activity
|
FLT3, KIT, SRC, TEK |
2.06057 |
|
[BP] GO:0050900 |
leukocyte migration
|
CNR2, FUT7, KIT, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK |
2.05769 |
|
[BP] GO:0072330 |
monocarboxylic acid biosynthetic process
|
ALOX12, ALOX15, CYP1A1, IDO1, PTGS1, PTGS2 |
2.05575 |
|
[BP] GO:0009889 |
regulation of biosynthetic process
|
ADORA3, ADRA2A, AKR1C3, APEX1, APP, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DHFR, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GSK3B, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP12, NR3C1, PIM1, POLA1, PPARA, PRKCA, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1 |
2.04976 |
|
[BP] GO:0070848 |
response to growth factor
|
APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 |
2.03906 |
|
[BP] GO:0003014 |
None
|
ADORA1, AKR1B1, AKR1C3, BCL2, HSD11B2 |
2.03906 |
|
[BP] GO:1902532 |
negative regulation of intracellular signal transduction
|
BCL2, DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH |
2.03893 |
|
[BP] GO:2001234 |
negative regulation of apoptotic signaling pathway
|
BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC, TERT |
2.0356 |
|
[BP] GO:0032210 |
regulation of telomere maintenance via telomerase
|
AURKB, SRC, TNKS, TNKS2 |
2.03365 |
|
[BP] GO:0014066 |
regulation of phosphatidylinositol 3-kinase signaling
|
EGFR, FLT3, KDR, KIT, TEK |
2.02135 |
|
[BP] GO:0016101 |
None
|
AKR1B10, AKR1C3, CYP1A1, CYP1B1, EGFR |
2.02135 |
|
[BP] GO:0022612 |
gland morphogenesis
|
BCL2, EGFR, POLB |
2.02077 |
|
[BP] GO:0051194 |
None
|
ESRRB, HTR2A, INSR |
2.02077 |
|
[BP] GO:0030520 |
intracellular estrogen receptor signaling pathway
|
ESR1, ESR2, SRC |
2.02077 |
|
[BP] GO:0050877 |
None
|
ADORA1, APP, CHRM1, CNR1, CNR2, CYP1B1, EGFR, GRIN2B, HTR2A, INSR, KIT, PTGS2, SLC6A4, TRPV1, TYR |
2.01814 |
|
[BP] GO:0051054 |
positive regulation of DNA metabolic process
|
AURKB, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 |
2.01588 |
|
[BP] GO:0002009 |
morphogenesis of an epithelium
|
BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC |
2.01497 |
|
[BP] GO:0051893 |
regulation of focal adhesion assembly
|
KDR, SMAD3, SRC, TEK |
2.00859 |
|
[BP] GO:0090109 |
regulation of cell-substrate junction assembly
|
KDR, SMAD3, SRC, TEK |
2.00859 |
|
[BP] GO:0006936 |
None
|
HTR1D, HTR2A, HTR2B, HTR7, KCNH2, PIK3CA, TRPV1 |
2.00609 |
|
[CC] GO:0031226 |
intrinsic component of plasma membrane
|
ADORA1, ADORA3, ADRA2A, APP, AXL, CA4, CHRM1, CHRM2, CHRM4, CNR1, CNR2, F10, F3, FLT3, GPR35, GRIN2B, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SLC6A2, SLC6A4, TEK, TRPV1 |
9.67495 |
|
[CC] GO:0005886 |
plasma membrane
|
ACHE, ADORA1, ADORA3, ADRA2A, ALOX12, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, EGFR, ESR1, F10, F3, FLT3, GBA2, GLO1, GPR35, GRIN2B, GSK3B, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1 |
9.11534 |
|
[CC] GO:0005887 |
integral component of plasma membrane
|
ADORA1, ADORA3, ADRA2A, APP, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, GPR35, GRIN2B, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SLC6A2, SLC6A4, TEK, TRPV1 |
8.22232 |
|
[CC] GO:0044459 |
plasma membrane part
|
ADORA1, ADORA3, ADRA2A, ALOX15, APP, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRIN2B, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, KIT, MET, PTGS2, SLC6A2, SLC6A4, SRC, TEK, TRPV1 |
7.78612 |
|
[CC] GO:0016020 |
membrane
|
ACHE, ADORA1, ADORA3, ADRA2A, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, GPR35, GRIN2B, GSK3B, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TRPV1, TYR |
7.12916 |
|
[CC] GO:0044425 |
membrane part
|
ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GPR35, GRIN2B, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, KIT, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SLC6A2, SLC6A4, SRC, TBXAS1, TEK, TRPV1, TYR |
5.38021 |
|
[CC] GO:0044464 |
cell part
|
ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, GRIN2B, GSK3B, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TYR, XDH |
4.10051 |
|
[CC] GO:0045121 |
membrane raft
|
APP, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK |
3.96733 |
|
[CC] GO:0098857 |
membrane microdomain
|
APP, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK |
3.94 |
|
[CC] GO:0044444 |
cytoplasmic part
|
ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, AOX1, APEX1, APP, AURKB, BCL2, CA1, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CES1, CES2, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DHFR, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR2A, HTR4, HTR5A, IDO1, INSR, KCNH2, KDR, KIT, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PTGS1, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TYR, XDH |
3.82456 |
|
[CC] GO:0044432 |
endoplasmic reticulum part
|
APP, BCL2, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, EGFR, F10, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, PTPN1, TBXAS1 |
3.34927 |
|
[CC] GO:0098589 |
membrane region
|
APP, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK |
3.27968 |
|
[CC] GO:0005783 |
None
|
ADORA1, APEX1, APP, BCL2, CA4, CES1, CES2, CYP19A1, CYP2D6, FLT3, GBA2, HSPA1A, HTR5A, KDR, PRKCA, PTGS2, PTPN1, XDH |
3.16226 |
|
[CC] GO:0098590 |
plasma membrane region
|
ADORA1, ADRA2A, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, EGFR, GRIN2B, HTR2A, INSR, MET, PTGS2, SRC, TEK, TRPV1 |
2.96342 |
|
[CC] GO:0009330 |
None
|
TOP1, TOP2A |
2.79712 |
|
[CC] GO:0043005 |
None
|
ADORA1, APP, CA2, CHRM1, CHRM2, CNR1, CNR2, GRIN2B, HTR2A, HTR2B, HTR5A, PTGS2, SLC6A2, SLC6A4, SRC |
2.47899 |
|
[CC] GO:0031224 |
None
|
ACHE, ADORA1, ADORA3, ADRA2A, ALPL, APP, AXL, CA12, CA14, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP3A4, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GPR35, GRIN2B, HCAR2, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, SLC6A2, SLC6A4, TBXAS1, TEK, TRPV1, TYR |
2.47527 |
|
[CC] GO:0120025 |
None
|
ADORA1, AKR1B1, APP, CA2, CDK6, CHRM1, CHRM2, CNR1, CNR2, GRIN2B, HTR2A, HTR2B, HTR5A, HTR6, PIK3CA, PTGS2, SLC6A2, SLC6A4, SRC, TEK |
2.41059 |
|
[CC] GO:0005789 |
endoplasmic reticulum membrane
|
BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, EGFR, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, TBXAS1 |
2.3443 |
|
[CC] GO:0016323 |
basolateral plasma membrane
|
ADORA1, ADRA2A, CA2, CA4, CA9, EGFR, TEK |
2.31771 |
|
[CC] GO:0042995 |
cell projection
|
ADORA1, AKR1B1, APP, CA2, CDK6, CHRM1, CHRM2, CNR1, CNR2, GRIN2B, HTR2A, HTR2B, HTR5A, HTR6, PIK3CA, PTGS2, SLC6A2, SLC6A4, SRC, TEK |
2.14925 |
|
[CC] GO:0031233 |
None
|
CA4, F10, F3 |
2.13205 |
|
[MF] GO:0043167 |
ion binding
|
ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DHFR, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GRIN2B, GSK3B, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TYR, XDH |
18.7241 |
|
[MF] GO:0099528 |
None
|
CHRM1, CHRM2, CHRM4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 |
17.7834 |
|
[MF] GO:0046914 |
transition metal ion binding
|
ALOX12, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, GRIN2B, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, TBXAS1, TNKS, TYR, XDH |
17.3352 |
|
[MF] GO:0008227 |
None
|
ADRA2A, CHRM1, CHRM2, CHRM4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 |
16.9165 |
|
[MF] GO:0043176 |
None
|
HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 |
15.0864 |
|
[MF] GO:0051378 |
None
|
HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 |
15.0864 |
|
[MF] GO:0004993 |
None
|
HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 |
15.0864 |
|
[MF] GO:0099589 |
None
|
HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 |
15.0864 |
|
[MF] GO:0038023 |
signaling receptor activity
|
ADORA1, ADORA3, ADRA2A, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIN2B, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, KIT, MET, NR3C1, PPARA, RORC, TEK, TRPV1 |
14.8062 |
|
[MF] GO:0003824 |
catalytic activity
|
ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DHFR, DUSP3, EGFR, F10, F3, FLT3, FUT7, GBA2, GLO1, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PRKCA, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH |
14.2492 |
|
[MF] GO:0043169 |
cation binding
|
ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, GRIN2B, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH |
13.9953 |
|
[MF] GO:0060089 |
molecular transducer activity
|
ADORA1, ADORA3, ADRA2A, AXL, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIN2B, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, KIT, MET, NR3C1, PPARA, RORC, TEK, TRPV1 |
13.41 |
|
[MF] GO:0004872 |
receptor activity
|
ADORA1, ADORA3, ADRA2A, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIN2B, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, KIT, MET, NR3C1, PPARA, RORC, TEK, TRPV1 |
13.121 |
|
[MF] GO:0008144 |
drug binding
|
ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DHFR, EGFR, FLT3, GRIN2B, GSK3B, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, SLC6A4, SRC, TEK, TOP1, TOP2A, TRPV1 |
13.0885 |
|
[MF] GO:0030594 |
None
|
CHRM1, CHRM2, CHRM4, GRIN2B, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 |
13.0179 |
|
[MF] GO:0004871 |
signal transducer activity
|
ADORA1, ADORA3, ADRA2A, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIN2B, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNH2, KDR, KIT, MET, NR3C1, PPARA, RORC, SMAD3, TEK, TRPV1 |
12.4923 |
|
[MF] GO:0016491 |
oxidoreductase activity
|
AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DHFR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH |
11.9159 |
|
[MF] GO:0042165 |
neurotransmitter binding
|
ACHE, GRIN2B, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 |
11.2893 |
|
[MF] GO:0099600 |
transmembrane receptor activity
|
ADORA1, ADORA3, ADRA2A, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, F3, FLT3, GPR35, GRIN2B, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, TEK, TRPV1 |
10.0616 |
|
[MF] GO:0004888 |
transmembrane signaling receptor activity
|
ADORA1, ADORA3, ADRA2A, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, F3, FLT3, GPR35, GRIN2B, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, TEK, TRPV1 |
10.0616 |
|
[MF] GO:0070405 |
ammonium ion binding
|
ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, SLC6A4 |
9.70556 |
|
[MF] GO:0004089 |
carbonate dehydratase activity
|
CA1, CA12, CA14, CA2, CA4, CA7, CA9 |
9.35183 |
|
[MF] GO:0046872 |
metal ion binding
|
ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, GRIN2B, IDO1, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH |
8.66201 |
|
[MF] GO:0005506 |
iron ion binding
|
ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, TBXAS1, XDH |
8.46756 |
|
[MF] GO:0020037 |
heme binding
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, IDO1, PTGS1, PTGS2, SRC, TBXAS1 |
8.41306 |
|
[MF] GO:0046906 |
tetrapyrrole binding
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, IDO1, PTGS1, PTGS2, SRC, TBXAS1 |
8.08769 |
|
[MF] GO:0008270 |
zinc ion binding
|
CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, GRIN2B, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PPARA, PRKCA, PTPN1, RORC, SMAD3, TNKS |
7.82148 |
|
[MF] GO:0048037 |
cofactor binding
|
AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DHFR, HSD11B2, HSD17B1, IDO1, NQO2, POLA1, PTGS1, PTGS2, SRC, TBXAS1, XDH |
7.80715 |
|
[MF] GO:0004714 |
transmembrane receptor protein tyrosine kinase activity
|
AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK |
7.67232 |
|
[MF] GO:0016705 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
|
AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, PTGS1, PTGS2, TBXAS1, TYR |
7.54897 |
|
[MF] GO:0004497 |
monooxygenase activity
|
AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, TBXAS1, TYR |
7.32254 |
|
[MF] GO:0016835 |
carbon-oxygen lyase activity
|
APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB |
6.95417 |
|
[MF] GO:0019199 |
transmembrane receptor protein kinase activity
|
AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK |
6.7678 |
|
[MF] GO:0004672 |
protein kinase activity
|
AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KCNH2, KDR, KIT, MET, NUAK1, PIK3CA, PIM1, PRKCA, SRC, TEK, TOP1 |
6.54347 |
|
[MF] GO:0005496 |
steroid binding
|
CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NR3C1, RORC |
6.47992 |
|
[MF] GO:0097159 |
organic cyclic compound binding
|
ADORA1, ADRA2A, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DHFR, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GSK3B, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP12, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TOP1, TOP2A, TRPV1, XDH |
6.44122 |
|
[MF] GO:0070330 |
aromatase activity
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 |
6.2944 |
|
[MF] GO:1901363 |
heterocyclic compound binding
|
ADORA1, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DHFR, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GSK3B, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP12, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TOP1, TOP2A, TRPV1, XDH |
6.24952 |
|
[MF] GO:0016772 |
transferase activity, transferring phosphorus-containing groups
|
AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KCNH2, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PRKCA, SRC, TEK, TERT, TOP1 |
6.1013 |
|
[MF] GO:0016773 |
phosphotransferase activity, alcohol group as acceptor
|
AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KCNH2, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TEK, TOP1 |
6.00316 |
|
[MF] GO:0016712 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 |
5.97828 |
|
[MF] GO:0019825 |
oxygen binding
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4 |
5.97269 |
|
[MF] GO:0016614 |
oxidoreductase activity, acting on CH-OH group of donors
|
AKR1B1, AKR1B10, AKR1C3, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH |
5.95678 |
|
[MF] GO:0016301 |
kinase activity
|
AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KCNH2, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TEK, TOP1 |
5.40578 |
|
[MF] GO:0016836 |
hydro-lyase activity
|
CA1, CA12, CA14, CA2, CA4, CA7, CA9 |
5.40578 |
|
[MF] GO:0004930 |
None
|
ADORA1, ADORA3, ADRA2A, CHRM1, CHRM2, CHRM4, CNR1, CNR2, GPR35, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 |
5.29591 |
|
[MF] GO:0003707 |
steroid hormone receptor activity
|
ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC |
5.20716 |
|
[MF] GO:0019899 |
enzyme binding
|
ADRA2A, APP, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2C19, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, GRIN2B, GSK3B, HSPA1A, KCNH2, KIT, MET, NR3C1, POLA1, POLB, PPARA, PRKCA, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TNKS2, TOP2A |
4.98807 |
|
[MF] GO:0004713 |
protein tyrosine kinase activity
|
AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK |
4.88826 |
|
[MF] GO:0004716 |
signal transducer, downstream of receptor, with protein tyrosine kinase activity
|
EGFR, INSR, KDR, KIT |
4.86577 |
|
[MF] GO:0016829 |
lyase activity
|
APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1, POLB |
4.83598 |
|
[MF] GO:0043560 |
insulin receptor substrate binding
|
IGF1R, INSR, PIK3CA, PIK3CB |
4.48269 |
|
[MF] GO:0016702 |
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
|
ALOX12, ALOX15, ALOX5, IDO1, PTGS2 |
4.45431 |
|
[MF] GO:0098531 |
transcription factor activity, direct ligand regulated sequence-specific DNA binding
|
ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC |
4.41971 |
|
[MF] GO:0004879 |
nuclear receptor activity
|
ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC |
4.41971 |
|
[MF] GO:0033764 |
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
|
AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
4.38041 |
|
[MF] GO:0016701 |
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
|
ALOX12, ALOX15, ALOX5, IDO1, PTGS2 |
4.38041 |
|
[MF] GO:0016616 |
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
|
AKR1B1, AKR1B10, AKR1C3, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
4.32895 |
|
[MF] GO:0008289 |
lipid binding
|
ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, NR3C1, PPARA, RORC, TRPV1 |
4.32895 |
|
[MF] GO:0016229 |
steroid dehydrogenase activity
|
AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
4.23875 |
|
[MF] GO:0042562 |
hormone binding
|
ACHE, EGFR, HSD17B1, IGF1R, INSR, NQO2, NR3C1 |
4.22395 |
|
[MF] GO:0032403 |
protein complex binding
|
ACHE, ADORA1, ADRA2A, APEX1, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SMAD3, SRC |
4.0661 |
|
[MF] GO:0036094 |
small molecule binding
|
ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DHFR, EGFR, FABP3, FABP4, FLT3, GRIN2B, GSK3B, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, SRC, TEK, TOP1, TOP2A, TRPV1, XDH |
3.96733 |
|
[MF] GO:0044877 |
macromolecular complex binding
|
ACHE, ADORA1, ADRA2A, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SMAD3, SRC |
3.93708 |
|
[MF] GO:0008395 |
steroid hydroxylase activity
|
CYP19A1, CYP1A1, CYP2C19, CYP2D6, CYP3A4 |
3.92542 |
|
[MF] GO:0016907 |
None
|
CHRM1, CHRM2, CHRM4 |
3.8547 |
|
[MF] GO:0009055 |
electron transfer activity
|
AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, NQO2, XDH |
3.60621 |
|
[MF] GO:0000166 |
nucleotide binding
|
AOX1, AURKB, AXL, CDK6, CSNK2A1, DHFR, EGFR, FLT3, GSK3B, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, SRC, TEK, TOP1, TOP2A, TRPV1, XDH |
3.44407 |
|
[MF] GO:1901265 |
nucleoside phosphate binding
|
AOX1, AURKB, AXL, CDK6, CSNK2A1, DHFR, EGFR, FLT3, GSK3B, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, SRC, TEK, TOP1, TOP2A, TRPV1, XDH |
3.44376 |
|
[MF] GO:0016903 |
None
|
AKR1B1, AKR1B10, AKR1C3, AOX1, XDH |
3.42293 |
|
[MF] GO:0003674 |
molecular_function
|
ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CES1, CES2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, GRIN2B, GSK3B, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TYR, XDH |
3.38085 |
|
[MF] GO:0042802 |
identical protein binding
|
ACHE, ADRA2A, AOX1, APP, BCL2, CSNK2A1, EGFR, ESR1, ESR2, FLT3, IGF1R, KCNH2, KDR, KIT, MET, MMP9, NQO2, PTGS2, SLC6A4, SMAD3, TERT, TOP2A, TRPV1, TYR, XDH |
3.24616 |
|
[MF] GO:0043168 |
anion binding
|
ALOX15, AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, DHFR, EGFR, F10, F3, FABP3, FABP4, FLT3, GRIN2B, GSK3B, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TEK, TOP1, TOP2A, TRPV1, XDH |
3.24181 |
|
[MF] GO:0051213 |
dioxygenase activity
|
ALOX12, ALOX15, ALOX5, IDO1, PTGS1, PTGS2 |
3.05879 |
|
[MF] GO:0016725 |
oxidoreductase activity, acting on CH or CH2 groups
|
CYP1A2, CYP3A4, XDH |
3.05425 |
|
[MF] GO:0005524 |
ATP binding
|
AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TEK, TOP1, TOP2A, TRPV1 |
3.00417 |
|
[MF] GO:0032559 |
adenyl ribonucleotide binding
|
AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TEK, TOP1, TOP2A, TRPV1 |
2.85879 |
|
[MF] GO:0030554 |
adenyl nucleotide binding
|
AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TEK, TOP1, TOP2A, TRPV1 |
2.82145 |
|
[MF] GO:0004666 |
prostaglandin-endoperoxide synthase activity
|
PTGS1, PTGS2 |
2.79712 |
|
[MF] GO:0045550 |
None
|
AKR1B10, AKR1C3 |
2.79712 |
|
[MF] GO:0038052 |
RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
|
ESR1, ESR2 |
2.79712 |
|
[MF] GO:0047977 |
hepoxilin-epoxide hydrolase activity
|
ALOX12, ALOX15 |
2.79712 |
|
[MF] GO:0003845 |
None
|
HSD11B1, HSD11B2 |
2.79712 |
|
[MF] GO:0071886 |
None
|
HTR2A, HTR2C |
2.79712 |
|
[MF] GO:0046934 |
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
|
EGFR, KIT, MET, PIK3CA, PIK3CB |
2.69196 |
|
[MF] GO:0052813 |
phosphatidylinositol bisphosphate kinase activity
|
EGFR, KIT, MET, PIK3CA, PIK3CB |
2.60706 |
|
[MF] GO:0042803 |
protein homodimerization activity
|
ACHE, ADRA2A, AOX1, BCL2, FLT3, KCNH2, KIT, NQO2, PTGS2, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH |
2.47899 |
|
[MF] GO:0035004 |
phosphatidylinositol 3-kinase activity
|
EGFR, KIT, MET, PIK3CA, PIK3CB |
2.47899 |
|
[MF] GO:0050473 |
arachidonate 15-lipoxygenase activity
|
ALOX15, PTGS2 |
2.39672 |
|
[MF] GO:0047718 |
None
|
AKR1B10, AKR1C3 |
2.39672 |
|
[MF] GO:0070576 |
vitamin D 24-hydroxylase activity
|
CYP1A1, CYP3A4 |
2.39672 |
|
[MF] GO:0004949 |
None
|
CNR1, CNR2 |
2.39672 |
|
[MF] GO:0004052 |
arachidonate 12-lipoxygenase activity
|
ALOX12, ALOX15 |
2.39672 |
|
[MF] GO:0005330 |
None
|
SLC6A2, SLC6A4 |
2.39672 |
|
[MF] GO:0051120 |
hepoxilin A3 synthase activity
|
ALOX12, ALOX15 |
2.39672 |
|
[MF] GO:0047374 |
None
|
CES1, CES2 |
2.39672 |
|
[MF] GO:0140096 |
catalytic activity, acting on a protein
|
AURKB, AXL, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, F10, F3, FLT3, GSK3B, IGF1R, INSR, KCNH2, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PRKCA, PTPN1, SRC, TEK, TOP1 |
2.26418 |
|
[MF] GO:0015464 |
None
|
CHRM1, CHRM2, CHRM4 |
2.24767 |
|
[MF] GO:0019900 |
None
|
ADRA2A, AURKB, CDC25B, DUSP3, EGFR, ESR1, GSK3B, NR3C1, POLA1, PTPN1, SMAD3, SRC, TOP2A |
2.23483 |
|
[MF] GO:0019901 |
None
|
ADRA2A, CDC25B, DUSP3, EGFR, ESR1, GSK3B, NR3C1, POLA1, PTPN1, SMAD3, SRC, TOP2A |
2.19316 |
|
[MF] GO:0034056 |
estrogen response element binding
|
ESR1, ESR2 |
2.15021 |
|
[MF] GO:0034875 |
caffeine oxidase activity
|
CYP1A2, CYP3A4 |
2.15021 |
|
[MF] GO:0032795 |
None
|
ADORA1, ADRA2A |
2.15021 |
|
[MF] GO:0051425 |
None
|
APP, INSR |
2.15021 |
|
[MF] GO:0033695 |
oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor
|
CYP1A2, CYP3A4 |
2.15021 |
|
[MF] GO:0001223 |
transcription coactivator binding
|
ESR1, PPARA, TERT |
2.13205 |
