TCM Prescription: Qing Fei Decoction



Prescription Description
Prescription IDTCMF7410
Pinyin NameQing Fei Yin
Chinese Name清肺饮
English NameQing Fei Decoction
Function Description痰湿气逆而咳嗽
IndicationsQi uprising pattern
Disease ICD-11 Category SE92 [Qi uprising pattern (TM1), 气逆证 (TM1) ];
Human Tissues Associated with IndicationLung
ReferenceTaiwan Herbal Pharmacopeia 2nd Edition English Version
Reference Book/linkhttps://www.mohw.gov.tw/cp-3690-39025-2.html
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2322 Prunus armeniaca 杏仁 TCMH2322 ITSAJ4486-14
TCMH145 Bulbus fritillariae 贝母 TCMH145
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH1179 Citri exocarpium rubrum 橘红 TCMH1179
TCMH1903 Zingiber officinale 生姜 TCMH1903 ITSAO3969-14
Reference: Taiwan Herbal Pharmacopeia 2nd Edition English Version

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT316 MTNR1A Melatonin receptor 1A GPCR P48039
TCMT317 MTNR1B Melatonin receptor 1B GPCR P49286
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT899 ALDH2 Aldehyde dehydrogenase Oxidoreductase P05091
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1188 Leishmania braziliensis
TCMT1189 Pseudomonas fluorescens
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA, PTGES, TBXAS1, TRPV1 11.4093
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, NQO2, NR3C1, PIM1, PPARA, PTGES, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 9.58066
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOA, NQO2, TBXAS1, TYR, XDH 9.43853
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, GBA2, PIM1, PPARA, PTGES, TBXAS1, TYR, XDH 9.38534
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, NR3C1, PTGES, SRC, TYR 9.19811
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 8.97085
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, NR3C1, PPARA, PTGES, SRC, TRPV1, TYR 7.9778
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, F3, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MAOA, MET, MTNR1B, PPARA, SRC, TNKS, TNKS2, TRPV1, XDH 7.94669
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, NQO2, NR3C1, PIM1, PPARA, PTGES, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 7.84434
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.84434
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IGF1R, NR3C1, PPARA, PTGES, SRC, TRPV1, TYR 7.78122
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, NR3C1, PTGES, SRC, TRPV1, TYR 7.28211
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.10771
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, NR3C1, PPARA, SRC, TRPV1 6.9358
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.6985
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGES, TBXAS1 6.55482
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, GBA2, MAOA, TYR 6.53151
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, GBA2, MET, PPARA, PTGES, TBXAS1 6.47024
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES, TBXAS1 6.31516
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.25279
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, NR3C1, PPARA, PTGES, SRC, TRPV1, TYR 6.17249
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES, TBXAS1 6.11569
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.06722
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 6.01134
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, NR3C1, PPARA, SRC, TRPV1 5.56913
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PPARA, SRC, TYR 5.21911
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTGES 5.21911
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, NR3C1, PIM1, PPARA, PTGES, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 5.13816
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, PTGES, SRC 5.13169
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGES, TBXAS1 4.97185
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGES, TBXAS1 4.95676
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES, TBXAS1 4.95
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, NR3C1, PIM1, PPARA, PTGES, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 4.92168
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MTNR1B 4.75431
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PIM1, PPARA, SRC 4.58137
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.35439
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MET, MTNR1A, NR3C1, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 4.34822
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.33499
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, SRC 4.25658
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, PPARA, PTGES, TBXAS1 4.0997
[BP] GO:0010941 regulation of cell death AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SRC, TRPV1, XDH 4.02554
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, FABP3, HSD11B2, KDR, NR3C1, SRC, TRPV1 3.98025
[BP] GO:0043067 regulation of programmed cell death AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MET, PIM1, PTPN1, SRC, TRPV1, XDH 3.82921
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.76648
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 3.76149
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, NR3C1, SRC, TRPV1 3.74084
[BP] GO:0022900 electron transport chain AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.7094
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, SRC 3.62616
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.62316
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, IGF1R, KDR, MET, MTNR1A, NR3C1, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 3.56977
[BP] GO:0042127 regulation of cell proliferation AKR1B1, ALOX12, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, IGF1R, KDR, PIM1, PTGES, SRC, XDH 3.43121
[BP] GO:0010647 positive regulation of cell communication AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, KDR, MET, PTPN1, SRC, TNKS, TNKS2, XDH 3.39975
[BP] GO:0023056 positive regulation of signaling AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, KDR, MET, PTPN1, SRC, TNKS, TNKS2, XDH 3.38356
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, NR3C1, SRC, TRPV1 3.35622
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 3.34909
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, CDK6, KDR, SRC, TNKS, TNKS2, TRPV1 3.34909
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, PIM1, PPARA, PTGES, TBXAS1, TYR 3.34909
[BP] GO:0042981 regulation of apoptotic process AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, PIM1, PTPN1, SRC, TRPV1, XDH 3.30594
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.24805
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, KDR, NR3C1, SRC, TRPV1 3.24579
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, MTNR1A, MTNR1B, PPARA, SRC 3.22756
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, KDR, MET, PIM1, PPARA, SRC, TNKS2, TYR 3.20964
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.12607
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, PIM1, PPARA, SRC, TYR 3.05516
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, MAOA 2.99628
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 2.99388
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, NR3C1, SRC 2.9737
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, PTGES 2.97188
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, PIM1, PPARA, PTGES, TBXAS1, TYR 2.94638
[BP] GO:0060548 negative regulation of cell death AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, PIM1, PPARA, PTPN1, SRC 2.93561
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 2.89995
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, PIM1, PPARA, PTGES, TBXAS1, TYR 2.87511
[BP] GO:0009056 catabolic process ACHE, AKR1B10, ALDH2, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, GBA2, MAOA, SRC, XDH 2.85931
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.80587
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, NR3C1, SRC 2.78267
[BP] GO:0009115 None AOX1, XDH 2.7604
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.7604
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.7604
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.7604
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.73737
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA 2.73737
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MTNR1A, NR3C1, PPARA, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 2.72609
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, TYR 2.71368
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, SRC, TRPV1 2.6649
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, PIM1, PTPN1, SRC 2.6649
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, ALDH2, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2, MAOA, SRC, XDH 2.65999
[BP] GO:0042592 homeostatic process AKR1B1, ALOX12, AXL, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MET, MTNR1B, SRC, TRPV1 2.65434
[BP] GO:1901575 None ACHE, AKR1B10, ALDH2, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, GBA2, MAOA, XDH 2.60694
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, IGF1R, KDR, PIM1 2.60289
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.59546
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.59546
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1 2.58139
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PTPN1, SRC, TNKS, XDH 2.5468
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.52179
[BP] GO:0031325 positive regulation of cellular metabolic process ALOX15, AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MET, MTNR1A, NR3C1, PPARA, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 2.50439
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.49335
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.48313
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.4765
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, IGF1R, MET, PIM1, PPARA, SRC, TNKS2, TRPV1, TYR 2.4765
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.4714
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, NR3C1, PTPN1, SRC, TRPV1 2.45079
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.45079
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.4146
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.40954
[BP] GO:0042737 drug catabolic process ACHE, ALDH2, CYP1A2, CYP3A4, MAOA 2.40606
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, NQO2 2.40606
[BP] GO:0046110 None AOX1, XDH 2.40606
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.40606
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, MET, MTNR1B, TRPV1 2.40606
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, MET, PIM1, SRC, TYR 2.3804
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, KDR, SRC 2.35913
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PTPN1, SRC, TNKS, XDH 2.35913
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.34938
[BP] GO:0009893 positive regulation of metabolic process ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MET, MTNR1A, NR3C1, PPARA, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 2.34078
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.32568
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.32347
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, ALOX15, AXL, BCL2, CYP1B1, F3, FLT3, KDR, MET, PTPN1, SRC, XDH 2.29145
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA 2.27438
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.26849
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, IGF1R, KDR, MET, MTNR1B, PTPN1, SRC, TNKS, TNKS2, XDH 2.26389
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.26389
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, ALOX12, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KDR, MET, NR3C1, PIM1, PPARA, PTGES, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 2.26208
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 2.26208
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, KDR, SRC, TRPV1 2.25433
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, KDR, MET, PTPN1, SRC, TNKS, TNKS2, XDH 2.25043
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.24263
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.22872
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, IGF1R, KDR, MET, MTNR1B, PTPN1, SRC, TNKS, TNKS2, XDH 2.22293
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, HSD11B2, SRC, TRPV1, TYR 2.18315
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.18028
[BP] GO:0070213 None TNKS, TNKS2 2.18028
[BP] GO:0006145 None AOX1, XDH 2.18028
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.18028
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, FABP4, PTGES 2.1793
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, PIM1, PTPN1, SRC 2.1793
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, PTGES 2.15994
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.10223
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.10223
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, FLT3, HSD11B2, NR3C1 2.09869
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.05966
[BP] GO:0006091 generation of precursor metabolites and energy AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.05966
[BP] GO:0032879 regulation of localization ACHE, ALOX12, ALOX15, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MTNR1B, PPARA, PTPN1, SRC, TRPV1 2.04437
[BP] GO:0032845 None BCL2, SRC, TNKS, TNKS2, TRPV1 2.03698
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KDR, MET, NR3C1, PIM1, PPARA, PTGES, PTPN1, SRC, TNKS, TNKS2, TRPV1, XDH 2.02901
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.02133
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, SRC 2.0138
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MTNR1A, NR3C1, PPARA, SRC, TNKS, TNKS2, TRPV1 2.0138
[BP] GO:0043696 None CDK6, ESRRB 2.0138
[BP] GO:0043697 None CDK6, ESRRB 2.0138
[BP] GO:0010641 None F3, SRC 2.0138
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.0138
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.0138
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, ALOX5, AOX1, AURKB, BCL2, CA1, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MAOA, NQO2, NR3C1, PIM1, PTGES, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 3.12446
[CC] GO:0016020 membrane ACHE, ALOX12, ALOX15, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, MAOA, MET, MTNR1A, MTNR1B, PIM1, PTGES, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TYR 2.60201
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGES, TBXAS1 2.47892
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGES, PTPN1, TBXAS1 2.36208
[CC] GO:0097443 sorting endosome KDR, PTPN1 1.88146
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, NQO2, NR3C1, PIM1, PPARA, PTPN1, TBXAS1, TNKS, TYR, XDH 14.7089
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOA, NQO2, TBXAS1, TYR, XDH 10.8372
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALDH2, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, NQO2, PIM1, PTGES, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 10.6462
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.2725
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, NQO2, NR3C1, PIM1, PPARA, PTGES, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 9.38788
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, XDH 8.40859
[MF] GO:0048037 cofactor binding ALDH2, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B2, HSD17B1, NQO2, PTGES, SRC, TBXAS1, XDH 6.71084
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NR3C1 6.65342
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.53151
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, NR3C1, PPARA, TRPV1 6.00054
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.69111
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, NQO2, NR3C1, PIM1, PPARA, PTPN1, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 5.56913
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.34629
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.28797
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, NQO2, NR3C1, PIM1, PPARA, PTPN1, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 5.21819
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.13169
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, TYR 5.08506
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, NQO2, NR3C1, PPARA, PTPN1, TNKS 5.07024
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA 4.92939
[MF] GO:0009055 electron transfer activity AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, NQO2, XDH 4.75819
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC, TBXAS1 4.29546
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC, TBXAS1 4.09343
[MF] GO:0016903 None AKR1B1, AKR1B10, ALDH2, AOX1, XDH 4.07865
[MF] GO:0042562 hormone binding ACHE, HSD17B1, IGF1R, MTNR1A, NQO2, NR3C1 4.06802
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.0421
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.87882
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.87882
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, TYR 3.80942
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FLT3, IGF1R, KDR, MET, NQO2, PIM1, PPARA, SRC, TRPV1 3.73908
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.43121
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.42999
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.38356
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.34909
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.34583
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.25727
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.00262
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.7604
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.7604
[MF] GO:0003845 None HSD11B1, HSD11B2 2.7604
[MF] GO:0038023 signaling receptor activity AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MTNR1A, MTNR1B, NR3C1, PPARA, TRPV1 2.60866
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.49328
[MF] GO:0060089 molecular transducer activity AXL, CDK6, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MTNR1A, MTNR1B, NR3C1, PPARA, TRPV1 2.48313
[MF] GO:0008502 None MTNR1A, MTNR1B 2.40606
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.40606
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.40606
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.40606
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.38332
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.18028
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.18028
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.18028
[MF] GO:0004872 receptor activity AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MTNR1A, MTNR1B, NR3C1, PPARA, TRPV1 2.16336
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5 2.10223
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5 2.05966
[MF] GO:0036094 small molecule binding ALDH2, AOX1, AURKB, AXL, CDK6, CSNK2A1, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, MET, NQO2, PIM1, SRC, TRPV1, XDH 2.0138
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.0138
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.0138


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 11.1617
Metabolic pathways_Homo sapiens_hsa01100 MAOA, ALOX15, AKR1B1, ALOX12, TYR, CYP3A4, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, ALDH2, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, PTGES 9.8271
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.3988
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.3236
Tryptophan metabolism_Homo sapiens_hsa00380 ALDH2, MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 7.2581
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, TBXAS1, ALOX12, PTGES 4.5725
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.3133
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.3133
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.1436
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 3.2245
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP1A2, AOX1, CYP3A4 3.1636
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, MET, CDC25B 2.6488
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, KDR, MET, ESR1, IGF1R 2.5864
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.5864
Serotonergic synapse_Homo sapiens_hsa04726 MAOA, ALOX5, ALOX15, ALOX12 2.5864
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, TYR 2.8105
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.026
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, ALDH2, AKR1B1 2.8038
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, ALDH2, AKR1B1 2.2917
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 2.1008
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.1008
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, KDR, BCL2, MET, IGF1R 1.783
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 1.783
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 BCL2, PIM1, F3 1.783
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.1148
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, ESR1, ESR2 1.783
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.783
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, BCL2, MET, IGF1R 1.5518
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.511
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 MTNR1A, MTNR1B, TRPV1, NR3C1 1.4564
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2 1.4564
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.3862
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, IGF1R 1.2802
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.0882
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.2812
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3232
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3689
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.1003
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2802
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0565
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9821
Circadian entrainment_Homo sapiens_hsa04713 MTNR1A, MTNR1B 1.0731
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 ALDH2, AOX1 1.4564
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.1192
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 0.9889
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.0249
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2802
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.9957
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1892
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.082
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.963
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.9516
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.2566
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.4791
Arginine and proline metabolism_Homo sapiens_hsa00330 ALDH2, MAOA 1.4562
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.963
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.8874
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.8674
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8775
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.9516
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7418
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6807
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.6788
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.783
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.908
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2696
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.3191
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3657
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3559
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3759
cAMP signaling pathway_Homo sapiens_hsa04024 PPARA 0.3389
Alcoholism_Homo sapiens_hsa05034 MAOA 0.3634
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3557
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4235
Histidine metabolism_Homo sapiens_hsa00340 ALDH2, MAOA 1.8887
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4111
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4075
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3953
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4235
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4219
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4346
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4499
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4454
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4346
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4454
Sphingolipid signaling pathway_Homo sapiens_hsa04071 BCL2 0.4499
Axon guidance_Homo sapiens_hsa04360 MET 0.4405
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA 0.4384
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7479
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5058
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5058
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5306
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5174
GnRH signaling pathway_Homo sapiens_hsa04912 SRC 0.5258
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5173
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5173
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5306
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5306
Gap junction_Homo sapiens_hsa04540 SRC 0.5306
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5303
Peroxisome_Homo sapiens_hsa04146 XDH 0.5367
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5737
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5514
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5727
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5857
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5943
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5943
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5943
Amphetamine addiction_Homo sapiens_hsa05031 MAOA 0.5943
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.587
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6059
Shigellosis_Homo sapiens_hsa05131 SRC 0.5943
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5977
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4 0.6287
Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 ALDH2 0.5943
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.6287
Lysine degradation_Homo sapiens_hsa00310 ALDH2 0.6488
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6517
Malaria_Homo sapiens_hsa05144 MET 0.6627
Cocaine addiction_Homo sapiens_hsa05030 MAOA 0.6627
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6696
Bladder cancer_Homo sapiens_hsa05219 SRC 0.6988
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.7033
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6696
Fatty acid degradation_Homo sapiens_hsa00071 ALDH2 0.6807
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.7033
Pyruvate metabolism_Homo sapiens_hsa00620 ALDH2 0.7033
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7857
beta-Alanine metabolism_Homo sapiens_hsa00410 ALDH2 0.7857
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8019
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8292
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.026
Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 ALDH2 0.8256
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8256
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.9622
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9516
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.001
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2802


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)