TCM Prescription: Xin Yi Powder



Prescription Description
Prescription IDTCMF7347
Pinyin NameXin Yi San
Chinese Name辛夷散
English NameXin Yi Powder
Function Description感冒初期引起之鼻塞不通, 鼻流清涕
IndicationsCommon cold disorder, Common cold
Disease ICD-11 Category SA60 [Common cold disorder (TM1), 感冒 (TM1) ];
CA00 [Acute nasopharyngitis, 急性鼻咽炎 ];
Human Tissues Associated with IndicationLung, blood
ReferenceTaiwan Herbal Pharmacopeia 2nd Edition English Version
Reference Book/linkhttps://www.mohw.gov.tw/cp-3690-39025-2.html
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2316 Magnolia liliflora 辛夷 TCMH2316 GBVT919-13, GBVT884-13
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
TCMH670 Ligusticum sinense 藁本 TCMH670 ITSAP3226-14
TCMH1906 Cimicifuga foetida 升麻 TCMH1906
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH1531 Akebia quinata 木通 TCMH1531 ITSAJ4440-14
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH226 Camellia sinensis 茶叶 TCMH226 ITSAG2924-14
Reference: Taiwan Herbal Pharmacopeia 2nd Edition English Version

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT594 PTAFR Platelet activating factor receptor GPCR P25105
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT707 ADORA2A Adenosine A2a receptor GPCR P29274
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT781 CYP2E1 Cytochrome P450 2E1 Oxidoreductase P05181
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1283 Human enterovirus 71
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA 9.94587
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADORA2A, ADRB1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TYR, XDH 9.75099
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IGF1R, MMP2, MMP9, PPARA, PTAFR, RORC, SRC, TYR 9.58504
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 9.40139
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 9.40139
[BP] GO:0010033 response to organic substance ADORA2A, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, PPARA, PTAFR, RORC, SRC, TYR 9.40139
[BP] GO:0042221 response to chemical ABCB1, ADORA2A, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, PTAFR, RORC, SRC, TERT, TYR 9.32621
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, PTAFR, RORC, SRC, TYR 9.08654
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, ADORA2A, ADRB1, AKR1B1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CDK6, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F3, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MET, PPARA, PTAFR, SRC, TERT, TNKS, TNKS2, XDH 8.61929
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA2A, ADORA3, AKR1B1, APP, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, ESRRA, F3, FABP3, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1, PTAFR, SRC, TERT, XDH 8.30769
[BP] GO:0014070 response to organic cyclic compound ADORA2A, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, HSD11B2, PTAFR, RORC, SRC, TYR 8.10494
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADORA2A, ADRB1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HCAR2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 8.00439
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, PTAFR, SRC 7.70092
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADORA2A, ADRB1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 7.53846
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADORA2A, ADRB1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F3, FLT3, HCAR2, KDR, MET, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 7.52821
[BP] GO:0023056 positive regulation of signaling ADORA1, ADORA2A, ADRB1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F3, FLT3, HCAR2, KDR, MET, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 7.50939
[BP] GO:0032502 developmental process ACHE, ADORA1, ADORA2A, ADRB1, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, KDR, MET, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TERT, TNKS2, TYR 7.33023
[BP] GO:0044281 small molecule metabolic process ADORA2A, AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, GBA2, PIM1, PPARA, PTAFR, TYR, XDH 7.19558
[BP] GO:0044237 cellular metabolic process ACHE, ADORA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, PIM1, PPARA, PTAFR, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TYR, XDH 7.07945
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.76957
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADORA2A, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.65136
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PPARA, SRC, TYR 6.40746
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC, TERT 6.23976
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PTAFR, RORC, SRC, TERT 6.23383
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, PPARA, PTAFR, SRC 6.15738
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.15485
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADORA2A, AURKB, BCL2, CA2, CA7, CACNA1C, CDK6, EGFR, HCAR2, KDR, SRC, TNKS, TNKS2 6.15301
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADORA2A, ADRB1, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.05501
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA2A, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, ERBB2, F3, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 6.05501
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CACNA1C, CDK6, CYP19A1, CYP1B1, EGFR, ERBB2, F3, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 6.04382
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADORA2A, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, MMP9, PIM1, PPARA, RORC, SRC, TYR 5.98377
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, PIM1, SRC 5.98377
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADORA2A, ADRB1, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 5.9636
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, ADORA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TYR, XDH 5.85096
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.82154
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, ERBB2, F3, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 5.78883
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, ADORA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TYR, XDH 5.76878
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADORA2A, ADRB1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MMP9, PPARA, PTAFR, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 5.74251
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, PTAFR, RORC, SRC 5.63089
[BP] GO:0010941 regulation of cell death ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, XDH 5.62642
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADORA2A, ADRB1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, F3, FLT3, KDR, MET, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 5.53164
[BP] GO:0043067 regulation of programmed cell death ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TERT, XDH 5.51442
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADORA2A, ADRB1, APP, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MET, MMP9, PPARA, PTAFR, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 5.42806
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, ERBB2, ESR1, F3, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1, PTAFR, TERT 5.42806
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.42806
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADORA2A, ADRB1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, ESRRA, F3, FABP4, FLT3, KDR, MET, MMP2, MMP9, PTAFR, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 5.39275
[BP] GO:0032501 multicellular organismal process ADORA1, ADORA2A, ADRB1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, BCL2, CACNA1C, CYP19A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, IGF1R, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTAFR, RORC, SRC, TNKS2, TYR 5.35722
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADORA2A, ADRB1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MET, MMP9, PPARA, PTAFR, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 5.27964
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 5.17387
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 5.14414
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 5.13898
[BP] GO:0060548 negative regulation of cell death ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT 5.06303
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA2A, ADORA3, APP, AXL, BCL2, CA2, CA7, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F3, HCAR2, IGF1R, KDR, MET, MMP9, PPARA, PTAFR, PTPN1, SRC, TERT 5.04934
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7, PTAFR 5.04264
[BP] GO:0042981 regulation of apoptotic process ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT, XDH 5.00585
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, FABP3, FABP4, FUT7, GBA2, MET, PPARA 5.00585
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA2A, ADORA3, ADRB1, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, PTAFR, PTPN1, RORC, SRC, TERT, TYR 4.97217
[BP] GO:0042493 response to drug ABCB1, ADORA2A, AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, EGFR, FABP3, HSD11B2, KDR, PTAFR, SRC 4.97217
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADORA2A, ADRB1, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PPARA, PTAFR, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.89379
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TERT 4.86327
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, F3, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 4.72564
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 4.69801
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.69801
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.55013
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PTAFR, PTPN1, RORC, SRC, TERT 4.50674
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ADORA2A, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, PTAFR, PTPN1, SRC, TNKS, XDH 4.43805
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.38039
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, EGFR, ERBB2, ESR1, F3, FLT3, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 4.36473
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MMP9, PPARA, PTAFR, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 4.34867
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 4.32993
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADORA2A, ADRB1, APP, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FLT3, KDR, MMP9, PTAFR, PTPN1, SRC, XDH 4.27381
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADORA2A, ADRB1, APP, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FLT3, KDR, MMP9, PTAFR, PTPN1, SRC, XDH 4.27381
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, APP, AXL, BCL2, CYP1B1, EGFR, ERBB2, F3, FLT3, KDR, MET, PTPN1, SRC, XDH 4.24308
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT 4.22075
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTAFR, TERT 4.18654
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA2A, ADORA3, ADRB1, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 4.14211
[BP] GO:0006793 phosphorus metabolic process ACHE, ADORA2A, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, PTAFR, PTPN1, SRC, TNKS, XDH 4.13541
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CDK6, CYP1B1, DNMT1, EGFR, ESR1, IGF1R, MMP2, MMP9, PTAFR, RORC, SRC 4.12264
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, HSD11B2, MMP2, PPARA, PTAFR, SRC, TERT, TYR 4.12264
[BP] GO:0007165 signal transduction ADORA1, ADORA2A, ADORA3, ADRB1, AKR1B1, APP, AXL, BCL2, CA1, CA2, CACNA1C, CDK6, CSNK2A1, CYP1B1, DNMT1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, RORC, SRC, TNKS, TNKS2 4.10338
[BP] GO:0010243 response to organonitrogen compound ADORA2A, AKR1B1, APP, DNMT1, EGFR, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, PTAFR, SRC, TYR 4.09148
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 4.09148
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, ADRB1, APP, AURKB, BCL2, CDC25B, EGFR, ERBB2, ESR1, ESR2, F3, FLT3, MET, MMP9, PTAFR, PTPN1, SRC, TERT, TNKS, XDH 4.0849
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, EGFR, F3, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 4.06432
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 4.06428
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 4.06233
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTAFR, RORC, SRC 4.06233
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, EGFR, ERBB2, ESR1, FLT3, MET, PIM1, SRC, TYR 4.05744
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, ADORA2A, CA2, CA7, PTAFR 4.05744
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, ADORA2A, APP, CDK6, CYP19A1, DYRK1A, EGFR, ESR1, F3, FABP4, IGF1R, MET, MMP2, PPARA, PTPN1, SRC, TERT, XDH 3.9933
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, EGFR, F3, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 3.94937
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 3.91969
[BP] GO:0035588 None ADORA1, ADORA2A, ADORA3, PTAFR 3.91545
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA2A, ADORA3, ADRB1, APP, AXL, BCL2, CA2, CACNA1C, CDK6, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F3, HCAR2, KDR, MET, MMP9, PIM1, PTAFR, SRC, TERT, TNKS2, XDH 3.90884
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, EGFR, ESR1, PPARA, RORC, SRC 3.89253
[BP] GO:2000021 regulation of ion homeostasis ADORA1, ADORA2A, BCL2, CA2, CA7, CACNA1C, KDR, SRC 3.89241
[BP] GO:0009891 positive regulation of biosynthetic process ADORA2A, ADRB1, APP, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, PPARA, PTAFR, RORC, SRC, TERT, TNKS, TNKS2 3.89241
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, EGFR, F3, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 3.85776
[BP] GO:0042592 homeostatic process ADORA1, ADRB1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, FABP4, FLT3, MET, SRC, TERT 3.81244
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, GBA2, MMP1, MMP2, MMP9, SRC, XDH 3.8081
[BP] GO:1901698 response to nitrogen compound ADORA2A, AKR1B1, APP, DNMT1, EGFR, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, PTAFR, SRC, TYR 3.77939
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2, PTAFR, SRC 3.74739
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, EGFR, F3, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 3.73014
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, ADORA2A, APP, AXL, BCL2, CA2, CYP19A1, EGFR, ERBB2, HCAR2, PTAFR, SRC, TERT 3.70876
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.69679
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, HSD11B2, PTAFR, SRC 3.68434
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.67257
[BP] GO:0032846 positive regulation of homeostatic process ADORA2A, AURKB, CA2, CA7, EGFR, HCAR2, TNKS, TNKS2 3.66988
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA2A, ADORA3, ADRB1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, F3, FABP4, FLT3, IGF1R, MET, MMP9, PIM1, PPARA, PTAFR, PTPN1, SRC, TERT, TNKS, XDH 3.6697
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 3.66373
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process ADORA2A, ADRB1, APP, AURKB, DNMT1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MET, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2 3.65877
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.65877
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.65877
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.65877
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADORA2A, ADRB1, APP, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PPARA, PTAFR, PTPN1, SRC, XDH 3.60356
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.56384
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, TERT 3.56205
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADORA2A, ADRB1, APP, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PPARA, PTAFR, PTPN1, SRC, XDH 3.56085
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, PTAFR, TYR 3.54974
[BP] GO:0048869 cellular developmental process ACHE, ADORA2A, ADRB1, ALPL, APP, AXL, BCL2, CDC25B, CDK6, CYP1A1, EGFR, ERBB2, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, KDR, MET, MMP2, MMP9, RORC, SRC, TERT 3.54617
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTAFR, SRC 3.53981
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.52818
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.5261
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.5261
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.49277
[BP] GO:0031328 positive regulation of cellular biosynthetic process ADORA2A, ADRB1, APP, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MET, PPARA, PTAFR, RORC, SRC, TERT, TNKS, TNKS2 3.47892
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA2A, ADORA3, ADRB1, APP, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, F3, FABP4, FLT3, IGF1R, MMP9, PTAFR, PTPN1, SRC, TERT, TNKS, XDH 3.47728
[BP] GO:0044092 negative regulation of molecular function ADORA2A, ADORA3, APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 3.45283
[BP] GO:0035587 None ADORA1, ADORA2A, ADORA3, PTAFR 3.43118
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.43118
[BP] GO:0009966 regulation of signal transduction ADORA1, ADORA2A, ADRB1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, F3, FLT3, IGF1R, KDR, MET, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 3.39272
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADORA2A, BCL2, CDK6, CYP19A1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, IGF1R, MET, MMP9, PPARA, PTPN1, SRC, TERT, XDH 3.38207
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, EGFR, ERBB2, PPARA 3.36163
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA2A, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, EGFR, ERBB2, F3, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTAFR, PTPN1, SRC, TNKS, TNKS2 3.36163
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT, TNKS 3.3599
[BP] GO:0048143 None ADORA2A, APP, EGFR 3.35755
[BP] GO:0001973 None ADORA1, ADORA2A, ADORA3 3.35755
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC, TERT 3.32968
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, ADORA2A, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, DYRK1A, EGFR, ERBB2, ESR1, F3, FLT3, FUT7, GBA2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 3.32259
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADORA2A, APP, AURKB, BCL2, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, HCAR2, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 3.32159
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, MMP2, MMP9, PTAFR, SRC 3.30989
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADORA2A, APP, CA2, CA7, EGFR 3.27033
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ADORA2A, APP, AXL, BCL2, CA2, CA7, CACNA1C, CYP19A1, EGFR, ERBB2, HCAR2, MMP9, PPARA, PTAFR, PTPN1, SRC, TERT 3.25582
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC, TERT 3.25582
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADORA2A, CA2, CA7 3.24657
[BP] GO:0051240 positive regulation of multicellular organismal process ADORA2A, ADRB1, APP, AXL, BCL2, CA2, CYP1B1, EGFR, ESRRB, F3, HCAR2, KDR, MET, MMP9, PIM1, PTAFR, SRC, TERT 3.2387
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.23647
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 3.22921
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.18457
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTAFR, TERT 3.14956
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, EGFR, KDR, PTAFR, SRC 3.09973
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRB1, APP, AURKB, BCL2, CDC25B, EGFR, ERBB2, ESR1, F3, FLT3, PTAFR, PTPN1, SRC, TERT, TNKS, XDH 3.07288
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC, TERT 3.0046
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, ERBB2, F3, MET, SRC, XDH 2.96123
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA 2.96123
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, HSD11B2, PTAFR 2.96123
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, F3, FLT3, KDR, MMP9, PTAFR, PTPN1, SRC, XDH 2.94518
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, DNMT1, EGFR, IGF1R, SRC, TNKS, TNKS2 2.94228
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADORA2A, APP, BACE1, CA2, CA7, EGFR 2.91923
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADORA2A, APP, BACE1, CA2, CA7, EGFR 2.91923
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA2A, ADORA3, ADRB1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTAFR, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.90748
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC, TNKS 2.90748
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.90748
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADORA2A, CA2, CA7 2.90748
[BP] GO:0009115 None AOX1, XDH 2.9023
[BP] GO:0009636 response to toxic substance ADORA2A, AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, KDR, SRC 2.9023
[BP] GO:0045776 None ADORA1, ADRB1, PPARA, PTAFR 2.82651
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MET, PPARA, PTAFR, RORC, SRC, TERT, TNKS, TNKS2 2.82383
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.8198
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADORA2A, APP, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP4, FLT3, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.79937
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, ERBB2, F3, MET, SRC 2.77841
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.73605
[BP] GO:0003018 None ADORA1, ADORA2A, ADRB1, EGFR, PTAFR, SRC 2.73605
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.73558
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, F3, FLT3, KDR, MMP9, PTAFR, PTPN1, SRC, XDH 2.71091
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.67275
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.66563
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.65863
[BP] GO:0070920 None EGFR, ESR1, TERT 2.65863
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, KDR, SRC 2.65863
[BP] GO:0003014 None ADORA1, ADORA2A, AKR1B1, BCL2, HSD11B2 2.65733
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.63518
[BP] GO:1901184 None ADORA1, APP, EGFR, ERBB2, MMP9 2.59818
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, DNMT1, EGFR, ERBB2, ESR1, FLT3, IGF1R, MMP2, PTAFR, SRC 2.58786
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.58739
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.58251
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 2.5752
[BP] GO:0097755 None ADORA2A, ADRB1, EGFR, PTAFR 2.56747
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.54638
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.52
[BP] GO:0010676 None ESRRB, PPARA, PTAFR, SRC 2.50664
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA2A, ADORA3, APP, BCL2, CDK6, CYP1B1, ERBB2, FABP3, TERT, XDH 2.48954
[BP] GO:0046110 None AOX1, XDH 2.4895
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.4895
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.4841
[BP] GO:0071396 cellular response to lipid AXL, CDK6, EGFR, ESR1, FLT3, PTAFR, RORC, SRC 2.48149
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DYRK1A, EGFR, ERBB2, ESR1, ESR2, IGF1R, MET, MMP9, PTPN1, SRC, TERT, XDH 2.48069
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.46853
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DYRK1A, EGFR, ERBB2, ESR1, ESR2, IGF1R, MET, MMP9, PTPN1, SRC, TERT, XDH 2.46853
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.46708
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, PTAFR, SRC 2.45848
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.45848
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA2A, ADORA3, ADRB1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTAFR, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.45848
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FLT3, KDR, MMP9, PTPN1, SRC, XDH 2.45838
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, PPARA, RORC, SRC 2.44008
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, MMP9, TERT 2.41245
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, PPARA 2.39456
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, SRC 2.38875
[BP] GO:0019538 protein metabolic process ACHE, ADORA2A, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, ESR1, F3, FLT3, FUT7, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2 2.37219
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9 2.36319
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, RORC 2.36319
[BP] GO:0051338 regulation of transferase activity ADORA1, ADORA2A, APP, AURKB, CDC25B, EGFR, ERBB2, FABP4, FLT3, IGF1R, PTPN1, SRC, TNKS 2.35895
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, ADORA2A, APP, BCL2, CA2, CA7, CACNA1C, MMP9, PTAFR 2.34415
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, BCL2, DNMT1, ESR1, IGF1R, KDR, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.33971
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA2A, ADORA3, ADRB1, AKR1B1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, HSD11B2, MMP2, MMP9, PPARA, PTAFR, PTPN1, SRC, TERT 2.31304
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.31155
[BP] GO:0051047 None ACHE, ADORA1, ADORA2A, CYP19A1, EGFR, HCAR2, PTAFR, SRC 2.30668
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.30617
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.30617
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA2A, ADORA3, ADRB1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HCAR2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TYR, XDH 2.30224
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SRC 2.30166
[BP] GO:0071229 cellular response to acid chemical DNMT1, EGFR, KDR, MMP2, PTAFR, SRC 2.29175
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.29175
[BP] GO:0010675 None ESRRB, PPARA, PTAFR, RORC, SRC 2.26154
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.25724
[BP] GO:0070213 None TNKS, TNKS2 2.2547
[BP] GO:0006145 None AOX1, XDH 2.2547
[BP] GO:1901529 None ABCB1, PTAFR 2.2547
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.2547
[BP] GO:0035556 intracellular signal transduction ADORA2A, ADRB1, AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, DNMT1, EGFR, ERBB2, IGF1R, KDR, MET, PTAFR, PTPN1, SRC 2.25028
[BP] GO:0002682 regulation of immune system process ADORA1, ADORA2A, APP, AXL, BCL2, CA2, CDK6, CYP19A1, ERBB2, ESR1, ESRRA, HCAR2, MMP2, PTAFR, PTPN1, SRC 2.24838
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DNMT1, EGFR, IGF1R, MMP2, PTAFR, SRC 2.23205
[BP] GO:0051881 regulation of mitochondrial membrane potential ADORA2A, BCL2, KDR, SRC 2.23205
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.23205
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ERBB2, FLT3, KDR, MMP9, PTPN1, SRC, XDH 2.23205
[BP] GO:0097746 None ADORA1, ADORA2A, ADRB1, EGFR, PTAFR 2.23205
[BP] GO:0035296 None ADORA1, ADORA2A, ADRB1, EGFR, PTAFR 2.23205
[BP] GO:0050793 regulation of developmental process ADRB1, APP, AXL, BCL2, CA2, CDK6, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F3, KDR, PIM1, PPARA, RORC, SRC, TERT, TNKS2, XDH 2.23205
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, EGFR, ERBB2, FLT3, KDR, PTPN1, SRC, XDH 2.23205
[BP] GO:0061900 None ADORA2A, APP, EGFR 2.22518
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.22518
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.22226
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADORA2A, APP, BCL2, CDC25B, EGFR, ERBB2, FABP4, FLT3, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 2.20612
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DYRK1A, ESR1, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.2019
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.19581
[BP] GO:0003013 None ADORA1, ADORA2A, ADRB1, EGFR, PTAFR, SRC 2.19581
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, GBA2, XDH 2.18834
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process ADORA2A, CSNK2A1, F3, MMP9, SRC, XDH 2.18834
[BP] GO:0044267 cellular protein metabolic process ADORA2A, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, ESR1, FLT3, FUT7, IGF1R, KDR, MET, MMP1, MMP2, PIM1, PTPN1, SRC, TNKS, TNKS2 2.17877
[BP] GO:0040014 regulation of multicellular organism growth ADRB1, APP, BCL2, TNKS2 2.17877
[BP] GO:0045913 None ESRRB, PPARA, PTAFR, SRC 2.15769
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, EGFR 2.1476
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADORA2A, APP, CDC25B, EGFR, ERBB2, FABP4, FLT3, IGF1R, PTPN1, SRC 2.1469
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.14212
[BP] GO:0050880 None ADORA1, ADORA2A, ADRB1, EGFR, PTAFR 2.13383
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, EGFR, PIM1, TERT, TNKS 2.12709
[BP] GO:0035150 None ADORA1, ADORA2A, ADRB1, EGFR, PTAFR 2.12239
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, FABP4, MET 2.10275
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.1027
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, EGFR, ERBB2, FLT3, KDR, MMP9, PTPN1, SRC, XDH 2.09675
[BP] GO:0043696 None CDK6, ESRRB 2.093
[BP] GO:0043697 None CDK6, ESRRB 2.093
[BP] GO:0010641 None F3, SRC 2.093
[BP] GO:0031324 negative regulation of cellular metabolic process ADORA2A, APP, AURKB, BCL2, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, IGF1R, MET, MMP9, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.093
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3 2.09117
[BP] GO:0031399 regulation of protein modification process ADORA1, ADORA2A, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ERBB2, FABP4, FLT3, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 2.08985
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA2A, ADORA3, ADRB1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTAFR, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.08184
[BP] GO:0090087 None ACHE, ADORA1, ADORA2A, APP, CA2, CACNA1C, EGFR, ERBB2, HCAR2, PTPN1, SRC 2.06337
[BP] GO:0010605 negative regulation of macromolecule metabolic process ADORA2A, APP, AURKB, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, IGF1R, KDR, MMP9, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.06114
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA2A, ADORA3, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTAFR, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.06114
[BP] GO:0001775 cell activation ADORA2A, ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, MMP9, PTAFR, RORC, SRC 2.05794
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DNMT1, EGFR, IGF1R, MMP2, PTAFR, SRC 2.05643
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA2A, ADORA3, ADRB1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTAFR, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.04706
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA2A, ADORA3, ADRB1, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.04642
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, EGFR, HSD11B2, SRC, TYR 2.03363
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.03363
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.01204
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA2A, ADORA3, ADRB1, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, F3, FLT3, FUT7, GBA2, HCAR2, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, MET, MMP2, PIM1, PTAFR, PTPN1, SRC, TERT, TNKS, TNKS2, TYR 3.81099
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA2A, ADORA3, ADRB1, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, EGFR, ERBB2, ESR1, F3, FLT3, GBA2, HCAR2, IGF1R, KDR, MET, MMP2, PIM1, PTAFR, PTPN1, SRC, TERT 3.27248
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTPN1 2.97983
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA2A, ADORA3, ADRB1, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, F3, FLT3, FUT7, GBA2, HCAR2, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, MET, PTAFR, PTPN1, SRC, TYR 2.53269
[CC] GO:0099056 None ADORA1, ADORA2A 2.4895
[CC] GO:0098889 None ADORA1, ADORA2A 2.4895
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, ERBB2 2.36994
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA7, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MMP2, MMP9, PIM1, PTAFR, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH 2.21126
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, GBA2, HSD11B1, HSD11B2, HSD17B2 2.1941
[CC] GO:0009986 cell surface ABCB1, ACHE, APP, AXL, BACE1, CA4, EGFR, F3, MET 2.08667
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TNKS, TYR, XDH 14.9226
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TYR, XDH 10.5832
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, EGFR, ERBB2, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH 10.5832
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.82778
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA, PTPN1, RORC, TNKS 6.5646
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.53466
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.17025
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 5.91578
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 5.69698
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 5.62642
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TERT, TNKS, TNKS2, TYR, XDH 5.51442
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.44534
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 5.3315
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 5.25549
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.25549
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TERT, TNKS, TNKS2, TYR, XDH 5.24803
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.17387
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.17387
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC 5.13898
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.06303
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA2A, ADORA3, ADRB1, AXL, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KDR, MET, PPARA, PTAFR, RORC 4.96265
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 4.89483
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.77088
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA2A, ADORA3, ADRB1, AXL, CDK6, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KDR, MET, PPARA, PTAFR, RORC 4.60709
[MF] GO:0004872 receptor activity ADORA1, ADORA2A, ADORA3, ADRB1, AXL, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KDR, MET, PPARA, PTAFR, RORC 4.19725
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC 4.13541
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 4.12264
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC 4.0594
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 3.99442
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 3.95726
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, PTAFR, RORC 3.91921
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B2, HSD17B1, SRC, XDH 3.76736
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 3.68434
[MF] GO:0004871 signal transducer activity ADORA1, ADORA2A, ADORA3, ADRB1, AXL, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KDR, MET, PPARA, PTAFR, RORC 3.67576
[MF] GO:0001609 None ADORA1, ADORA2A, ADORA3 3.65877
[MF] GO:0035586 None ADORA1, ADORA2A, ADORA3, PTAFR 3.59293
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.48342
[MF] GO:0042802 identical protein binding ACHE, ADORA2A, AOX1, APP, BCL2, CSNK2A1, DYRK1A, EGFR, ERBB2, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MMP9, TERT, TYR, XDH 3.44769
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.3777
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC 3.35755
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, ERBB2, KDR 3.35755
[MF] GO:0019899 enzyme binding ADORA2A, ADRB1, APP, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, EGFR, ERBB2, ESR1, ESR2, ESRRB, F3, MET, PPARA, PTAFR, PTPN1, SRC, TNKS2 3.31437
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.30989
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.30762
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.14966
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.99601
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC, TERT 2.92347
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.9023
[MF] GO:0003845 None HSD11B1, HSD11B2 2.9023
[MF] GO:0008389 None CYP2A13, CYP2A6 2.9023
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.75481
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, MET, PIM1, SRC, XDH 2.6625
[MF] GO:0019902 phosphatase binding BCL2, EGFR, ERBB2, MET, PPARA, PTPN1 2.61809
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, KDR, MMP9, PIM1, PPARA, PTPN1, SRC 2.45916
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.45848
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.41245
[MF] GO:0019903 protein phosphatase binding BCL2, EGFR, ERBB2, MET, PTPN1 2.30579
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.2547
[MF] GO:0000166 nucleotide binding ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, MET, PIM1, SRC, XDH 2.16502
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, EGFR, ERBB2, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, MET, PIM1, SRC, XDH 2.16361
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, ESRRB, FLT3, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC 2.13156
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA2A, ADORA3, ADRB1, AXL, EGFR, ERBB2, F3, FLT3, HCAR2, IGF1R, KDR, MET, PTAFR 2.10814
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA2A, ADORA3, ADRB1, AXL, EGFR, ERBB2, F3, FLT3, HCAR2, IGF1R, KDR, MET, PTAFR 2.10814
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.093
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, F3, FLT3, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, SRC 2.01866
[MF] GO:0043168 anion binding ABCB1, AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, PIM1, PTAFR, SRC, XDH 2.01204


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.8928
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.756
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.6983
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, CDK6, ABCB1, ERBB2, BCL2, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 6.7721
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, ERBB2, MMP9, EGFR 6.7721
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, ERBB2, MET, EGFR, IGF1R 6.7721
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, ERBB2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 6.1377
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, ERBB2, BCL2, MMP9, MET, EGFR, IGF1R 4.871
Metabolic pathways_Homo sapiens_hsa01100 DNMT1, AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 4.9821
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.4191
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, EGFR, ESR2 4.8419
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.2063
Focal adhesion_Homo sapiens_hsa04510 SRC, ERBB2, KDR, BCL2, MET, EGFR, IGF1R 4.1568
Calcium signaling pathway_Homo sapiens_hsa04020 ADORA2A, PTAFR, ERBB2, ADRB1, CACNA1C, EGFR 3.4389
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA2A, ADORA1, ADRB1, CACNA1C, PPARA 3.2224
Rap1 signaling pathway_Homo sapiens_hsa04015 ADORA2A, SRC, KDR, MET, EGFR, IGF1R 3.1526
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.9416
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, ERBB2, MET, EGFR 3.1526
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.1791
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, ADRB1, MET, EGFR, IGF1R 2.7547
Melanoma_Homo sapiens_hsa05218 CDK6, MET, EGFR, IGF1R 3.1161
Prostate cancer_Homo sapiens_hsa05215 ERBB2, BCL2, EGFR, IGF1R 2.7555
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.5989
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, CACNA1C, EGFR 2.7547
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.1444
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, KDR, BCL2, MET, EGFR, IGF1R 2.2179
HIF-1 signaling pathway_Homo sapiens_hsa04066 ERBB2, BCL2, EGFR, IGF1R 2.583
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 2.118
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, ERBB2, EGFR 2.2807
Glioma_Homo sapiens_hsa05214 CDK6, EGFR, IGF1R 2.1355
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, ADRB1 2.2807
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRB1, CACNA1C 1.961
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA2A, ADORA3, PTAFR, ADORA1, ADRB1 1.961
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, ERBB2, EGFR 2.1298
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, CACNA1C 2.1412
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.0708
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.118
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8884
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, ERBB2, EGFR 1.8884
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1 2.1119
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2, CACNA1C 1.6531
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, EGFR, IGF1R 1.6024
Gap junction_Homo sapiens_hsa04540 SRC, ADRB1, EGFR 1.8884
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, CACNA1C 1.6531
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.3994
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.5882
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, ADRB1, CACNA1C 1.3754
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.3232
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, CACNA1C, EGFR 1.3232
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP, CACNA1C 1.2787
MAPK signaling pathway_Homo sapiens_hsa04010 CACNA1C, EGFR, CDC25B 0.8918
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.9834
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.9133
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 1.0373
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.8821
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.0485
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.06
FoxO signaling pathway_Homo sapiens_hsa04068 EGFR, IGF1R 0.8142
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8821
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.803
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.8821
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.018
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8142
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADORA2A, CACNA1C 0.8748
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.8557
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7921
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.7867
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.131
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6613
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6068
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3275
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3019
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.6054
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.2274
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.5847
Endometrial cancer_Homo sapiens_hsa05213 ERBB2, EGFR 1.3874
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.1998
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3188
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3288
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3389
Alcoholism_Homo sapiens_hsa05034 ADORA2A 0.3263
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3182
Parkinson's disease_Homo sapiens_hsa05012 ADORA2A 0.3877
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3218
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3877
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3729
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3877
Phospholipase D signaling pathway_Homo sapiens_hsa04072 EGFR 0.3859
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3877
Platelet activation_Homo sapiens_hsa04611 SRC 0.4167
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4167
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4191
Axon guidance_Homo sapiens_hsa04360 MET 0.4113
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4167
Dopaminergic synapse_Homo sapiens_hsa04728 CACNA1C 0.4088
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4437
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.434
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4715
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4715
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4715
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4715
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4747
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4747
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.4747
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.474
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4806
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4814
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C 0.4715
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4821
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.4944
Salivary secretion_Homo sapiens_hsa04970 ADRB1 0.4821
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4821
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.4889
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4944
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5163
Peroxisome_Homo sapiens_hsa04146 XDH 0.4944
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4944
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4988
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5163
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5265
Long-term potentiation_Homo sapiens_hsa04720 CACNA1C 0.5376
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.4729
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5163
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5376
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5376
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5281
Amphetamine addiction_Homo sapiens_hsa05031 CACNA1C 0.5357
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5467
Shigellosis_Homo sapiens_hsa05131 SRC 0.5376
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5376
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5421
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.5421
Staphylococcus aureus infection_Homo sapiens_hsa05150 PTAFR 0.5698
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7615
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.6531
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.5983
Malaria_Homo sapiens_hsa05144 MET 0.6055
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6068
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.6068
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6068
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6068
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6173
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.6128
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.716
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.6613
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6531
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9485
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.783
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7457
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.2063
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7635
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7635
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7867
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7542
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.783
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.8821
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9694
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2787


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)