TCM Prescription: Di Zhen Granules



Prescription Description
Prescription IDTCMF7178
Pinyin NameDi Zhen Ke Li
Chinese Name地贞颗粒
English NameDi Zhen Granules
Function Description清虚热, 滋肝肾, 宁心养神。用于女性更年期综合征阴虚内热证, 症见烘热汗出, 心烦易怒, 手足心热, 失眠多梦, 腰膝酸软, 口干, 便秘等症。
IndicationsConstipation disorder, Heat pattern, Climacteric states
Disease ICD-11 Category SA57 [Constipation disorder (TM1), 便秘 (TM1) ];
SE72 [Heat pattern (TM1), 热证 (TM1) ];
GA30.00 [Menopausal or female climacteric states, 更年期或女性更年期状态 ];
Human Tissues Associated with IndicationBrain, Heart, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH449 Cortex lycii radicis 地骨皮 TCMH449
TCMH1597 Ligustrum lucidum 女贞子 TCMH1597 ITSAM2109-14
TCMH1503 Eclipta prostrata 墨旱莲 TCMH1503 ITSAP4516-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH1811 Semen astragali complanati 沙苑子 TCMH1811
TCMH816 Albizzia julibrissin 合欢皮 TCMH816 KT972683
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT281 DPP4 Dipeptidyl peptidase IV Unclassified P27487
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT718 TXN2 Thioredoxin, mitochondrial Unclassified Q99757
TCMT719 TXN Thioredoxin Unclassified P10599
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MET, PPARA, PTGES, TRPV1 12.0432
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 10.5655
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP12, NR3C1, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 10.3218
[BP] GO:0033993 response to lipid ALPL, AR, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, NR3C1, PTGES, RELA, RORC, SRC, TYR 10.1965
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MCL1, NR3C1, PPARA, PTGES, RELA, RORC, SRC, TRPV1, TYR 9.73764
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, AR, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, NR3C1, PTGES, RELA, RORC, SRC, TRPV1, TYR 9.22944
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AR, AXL, BCL2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IGF1R, NR3C1, PPARA, PTGES, RELA, RORC, SRC, TRPV1, TYR 9.22751
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, ALOX12, ALOX15, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CDK6, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, F3, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, KDR, MAOA, MCL1, MET, PPARA, SRC, TNKS, TNKS2, TRPV1, XDH 9.16347
[BP] GO:0048513 animal organ development ACHE, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSD17B3, KDR, MAP2K1, PPARA, PTPRS, RELA, SRC, TYR 9.07905
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, MAP3K7, NR3C1, PIM1, PPARA, RELA, RORC, SRC 8.92768
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 8.66835
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, GBA2, HSD17B3, PIM1, PPARA, PTGES, TYR, XDH 8.26057
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, NR3C1, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TNKS, TNKS2, TYR, XDH 7.9532
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAOA, TYR, XDH 7.86521
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MCL1, NR3C1, PPARA, PTGES, RELA, RORC, SRC, TRPV1, TYR 7.66506
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 7.5026
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, NR3C1, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 7.50172
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP12, NR3C1, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 7.40742
[BP] GO:0009725 response to hormone AKR1B1, ALPL, AR, BCL2, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, NR3C1, PPARA, RELA, SRC, TRPV1 7.29021
[BP] GO:0010647 positive regulation of cell communication AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 7.22187
[BP] GO:0023056 positive regulation of signaling AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 7.19718
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, GBA2, HSD17B3, MAOA, TYR 7.07304
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2, HSD17B3 7.07304
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, HSD17B3, KDR, MAP2K1, MCL1, PIM1, PPARA, PTPRS, RELA, RORC, SRC, TYR 7.04689
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, ALOX12, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, NR3C1, PIM1, PPARA, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 6.8336
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CACNA1C, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, HSD17B3, KDR, MAP2K1, MCL1, MET, PIM1, PPARA, PTPRS, RELA, RORC, SRC, TNKS2, TYR 6.75916
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.60069
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, PTGES, RELA, SRC 6.55906
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, AR, BCL2, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, NR3C1, PPARA, RELA, SRC, TRPV1 6.5273
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 6.46664
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES 6.46204
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES 6.11753
[BP] GO:0042127 regulation of cell proliferation AKR1B1, ALOX12, APP, AR, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, IGF1R, KDR, MAP2K1, MMP12, PIM1, PTGES, RELA, SRC, XDH 5.90348
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES 5.90348
[BP] GO:0010941 regulation of cell death AKR1B1, ALOX12, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MAP2K1, MCL1, MET, PIM1, PPARA, PTPN1, RELA, SRC, TRPV1, XDH 5.89519
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, NR3C1, RELA, RORC, SRC, TRPV1 5.88704
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, ALOX12, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, NR3C1, PIM1, PPARA, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 5.88545
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, GBA2, MET, PPARA, PTGES 5.88545
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 5.81796
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, ALOX15, APP, AR, AXL, BCL2, CYP1B1, F3, FLT3, KDR, MAP2K1, MAP3K7, MCL1, MET, PTPN1, RELA, SRC, XDH 5.81796
[BP] GO:0043067 regulation of programmed cell death AKR1B1, ALOX12, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MAP2K1, MCL1, MET, PIM1, PTPN1, RELA, SRC, TRPV1, XDH 5.79472
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, PTGES 5.6931
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 5.6362
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.48761
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, PTPN1, PTPRS, RELA, SRC, TNKS, TNKS2, XDH 5.37665
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 5.35468
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, NR3C1, RELA, RORC, SRC, TRPV1 5.28713
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, PTPN1, PTPRS, RELA, SRC, TNKS, TNKS2, XDH 5.28059
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 5.23725
[BP] GO:0042981 regulation of apoptotic process AKR1B1, ALOX12, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MAP2K1, MCL1, PIM1, PTPN1, RELA, SRC, TRPV1, XDH 5.20567
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CACNA1C, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, IGF1R, MCL1, MET, MMP12, PIM1, PPARA, RELA, RORC, SRC, TNKS2, TRPV1, TYR 5.18082
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, AR, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, RORC, SRC, TRPV1 5.00748
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, NR3C1, PPARA, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 4.99036
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, ALOX12, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KDR, MAP2K1, MCL1, MET, MMP12, NR3C1, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 4.93126
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES 4.80768
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MCL1, NR3C1, PTPN1, RELA, RORC, SRC, TRPV1 4.75876
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES 4.75733
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCL2, CA2, FLT3, HSD11B2, NR3C1, RELA, SRC 4.75683
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGES 4.71765
[BP] GO:0031325 positive regulation of cellular metabolic process ALOX15, APP, AR, AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, NR3C1, PPARA, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 4.67557
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 4.67212
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TNKS 4.61228
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MCL1, MET, PTPN1, RELA, SRC, XDH 4.5812
[BP] GO:0009893 positive regulation of metabolic process ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, NR3C1, PPARA, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 4.55417
[BP] GO:0060548 negative regulation of cell death AKR1B1, ALOX12, AR, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MCL1, MET, PIM1, PPARA, PTPN1, RELA, SRC 4.53854
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 4.52163
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, ALOX12, ALOX15, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KDR, MAP2K1, MCL1, MET, MMP12, NR3C1, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 4.44302
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 4.44131
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.41926
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, ALOX12, AR, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MCL1, MET, PIM1, PTPN1, RELA, SRC 4.28145
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, AR, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, IGF1R, KDR, MMP12, PIM1, RELA 4.18941
[BP] GO:0080134 regulation of response to stress ALOX12, APP, CDK6, CYP19A1, ESR1, F3, FABP4, IGF1R, MAP2K1, MAP3K7, MCL1, MET, MMP12, PPARA, PTPN1, PTPRS, RELA, SRC, XDH 4.11406
[BP] GO:0010604 positive regulation of macromolecule metabolic process ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, NR3C1, PPARA, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, XDH 4.09157
[BP] GO:0048608 reproductive structure development AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSD17B3, MAP2K1, SRC 4.07721
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PTPN1, PTPRS, SRC, TNKS, XDH 4.07721
[BP] GO:0048583 regulation of response to stimulus AKR1B1, ALOX12, ALOX15, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, PPARA, PTPN1, PTPRS, RELA, SRC, TNKS, TNKS2, XDH 4.04885
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MAP2K1, MET, MMP12, NR3C1, PPARA, RELA, RORC, SRC, TNKS, TNKS2, TRPV1 4.0234
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 3.94617
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, KDR, NR3C1, RELA, SRC, TRPV1 3.94606
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, CACNA1C, CDK6, KDR, SRC, TNKS, TNKS2, TRPV1 3.86522
[BP] GO:0050896 response to stimulus ACHE, AKR1B1, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MAP2K1, MAP3K7, MCL1, MMP12, NR3C1, PPARA, PTGES, PTPN1, RELA, RORC, SRC, TRPV1, TYR 3.85707
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, PPARA, PTGES 3.83761
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.80083
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PTPN1, PTPRS, SRC, TNKS, XDH 3.78547
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, HSD17B3, MAP2K1, SRC 3.74791
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, ALOX12, AR, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MCL1, PIM1, PTPN1, RELA, SRC 3.66764
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CDK6, CYP1A1, CYP1B1, FABP3, HSD11B2, KDR, NR3C1, RELA, SRC, TRPV1 3.63064
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.60164
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, ESR1, F3, FLT3, FUT7, GBA2, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP12, PIM1, PPARA, PTPN1, PTPRS, RELA, SRC, TNKS, TNKS2, TYR, XDH 3.59542
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, HSD17B3, TYR 3.56928
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MAP2K1, MET, MMP12, NR3C1, PPARA, RELA, RORC, SRC, TNKS, TNKS2, TRPV1 3.56155
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TNKS 3.56155
[BP] GO:0009966 regulation of signal transduction AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MCL1, MET, MMP12, PTPN1, PTPRS, RELA, SRC, TNKS, TNKS2, XDH 3.5398
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CDK6, CYP1B1, ESR1, IGF1R, NR3C1, RELA, RORC, SRC, TRPV1 3.5398
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, RELA, SRC 3.44886
[BP] GO:0048585 negative regulation of response to stimulus ALOX12, ALOX15, AR, BCL2, CDK6, CYP19A1, ESR1, ESR2, IGF1R, MCL1, MET, MMP12, PPARA, PTPN1, PTPRS, RELA, SRC, XDH 3.44287
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, BCL2, CYP1A1, ESR1, FLT3, MAP2K1, MET, PIM1, SRC, TYR 3.40933
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MAP2K1, MET, MMP12, NR3C1, PPARA, RELA, RORC, SRC, TNKS, TNKS2 3.40568
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1, HSD17B3 3.3708
[BP] GO:0042592 homeostatic process AKR1B1, ALOX12, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, ESR1, FABP3, FABP4, FLT3, MCL1, MET, SRC, TRPV1 3.33407
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, HSD11B2, IGF1R, PPARA, RELA, SRC, TRPV1 3.28805
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, APP, AR, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, KDR, MAP2K1, MAP3K7, MET, MMP12, PIM1, RELA, SRC, TRPV1 3.28074
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 3.26924
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.23823
[BP] GO:0071396 cellular response to lipid AR, AXL, CDK6, ESR1, FLT3, NR3C1, RELA, RORC, SRC 3.23698
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MAP2K1, MET, MMP12, NR3C1, PPARA, PTPN1, RELA, RORC, SRC, TNKS, TNKS2 3.21717
[BP] GO:0032879 regulation of localization ACHE, ALOX12, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1B1, F3, IGF1R, KDR, MAP2K1, MET, MMP12, PPARA, PTPN1, SRC, TRPV1 3.2051
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.2051
[BP] GO:0050793 regulation of developmental process ALOX12, APP, AR, AXL, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, ESRRB, F3, KDR, MAP2K1, PIM1, PPARA, PTPRS, RELA, RORC, SRC, TNKS2, TRPV1, XDH 3.2051
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 3.19718
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.15094
[BP] GO:0051239 regulation of multicellular organismal process ALOX12, APP, AR, AXL, BCL2, CA2, CACNA1C, CDK6, CYP1B1, ESR1, ESRRA, ESRRB, F3, KDR, MAP2K1, MAP3K7, MET, MMP12, PIM1, PTPRS, RELA, SRC, TNKS2, TRPV1, XDH 3.12807
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.11573
[BP] GO:0034097 response to cytokine ALOX15, AXL, BCL2, FABP4, FLT3, MCL1, PTGES, RELA, SRC, TRPV1 3.09508
[BP] GO:0007165 signal transduction AKR1B1, APP, AR, AXL, BCL2, CA1, CA2, CACNA1C, CDK6, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MCL1, MET, NR3C1, PIM1, PPARA, PTGES, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, TRPV1 3.04696
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 3.0342
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, PIM1, PPARA, PTGES, TYR 3.01373
[BP] GO:0009892 negative regulation of metabolic process APP, AR, AURKB, BCL2, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, IGF1R, KDR, MAP2K1, MCL1, MET, MMP12, NR3C1, PPARA, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 2.9808
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, NR3C1, SRC 2.9808
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, CACNA1C, KDR, SRC, TRPV1 2.9751
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, PTGES 2.95983
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.91809
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, KDR, RELA, SRC 2.88041
[BP] GO:0043410 positive regulation of MAPK cascade ALOX15, APP, AR, FLT3, KDR, MAP2K1, MAP3K7, PTPN1, SRC, XDH 2.88041
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.83311
[BP] GO:0009115 None AOX1, XDH 2.82376
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.82376
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.82376
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.82376
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, HSD17B3, MAP2K1, SRC 2.81585
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, MAOA 2.78546
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, PPARA, TRPV1 2.77622
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.76082
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, PTGES 2.76082
[BP] GO:0032101 regulation of response to external stimulus ALOX12, CYP19A1, ESR1, F3, FABP4, KDR, MAP2K1, MET, MMP12, PPARA, PTPRS, RELA 2.75938
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AR, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, KDR, MAP2K1, MCL1, MET, PTPRS, RORC, SRC 2.75526
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, NR3C1, SRC 2.71827
[BP] GO:0031324 negative regulation of cellular metabolic process APP, AR, AURKB, BCL2, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, IGF1R, MCL1, MET, MMP12, NR3C1, PPARA, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 2.71594
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, HSD11B2, RELA, SRC, TRPV1, TYR 2.68927
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, APP, BCL2, CA12, CA2, CA7, CACNA1C, ESR1, FABP3, FABP4, MET, TRPV1 2.65978
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, PIM1, PPARA, PTGES, TYR 2.64281
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, HSD17B3, PTGES 2.64109
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, MAP2K1, RELA, TYR 2.63161
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FLT3, KDR, MAP2K1, MAP3K7, PTPN1, SRC, XDH 2.62419
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FLT3, KDR, MAP2K1, MAP3K7, PTPN1, SRC, XDH 2.62419
[BP] GO:2000811 negative regulation of anoikis BCL2, MCL1, SRC 2.61708
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.61708
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.61708
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, PIM1, PPARA, PTGES, TYR 2.58004
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.54047
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1 2.51828
[BP] GO:2001237 negative regulation of extrinsic apoptotic signaling pathway AR, BCL2, MCL1, RELA, SRC 2.50217
[BP] GO:0042327 positive regulation of phosphorylation ALOX15, APP, AR, BCL2, CDC25B, ESRRB, FLT3, KDR, MAP2K1, MAP3K7, PTPN1, SRC, XDH 2.48413
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, RELA, SRC 2.47987
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.47745
[BP] GO:0043408 regulation of MAPK cascade ALOX15, APP, AR, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, PTPN1, SRC, XDH 2.4468
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.44575
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.44453
[BP] GO:1901654 None AKR1B1, AR, CSNK2A1, NR3C1, RELA, SRC 2.44453
[BP] GO:0046110 None AOX1, XDH 2.44453
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.44453
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, RELA, SRC 2.43629
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, GBA2, MAOA, MMP12, SRC, XDH 2.43259
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.43259
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, ESR1, IGF1R, KDR, MAP2K1, MET, SRC, TNKS, TNKS2 2.38882
[BP] GO:0042325 regulation of phosphorylation ALOX15, APP, AR, BCL2, CDC25B, ESRRB, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, PPARA, PTPN1, SRC, XDH 2.37163
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, SRC, TNKS 2.36681
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, RORC 2.33745
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, PTGES, RELA, SRC 2.33092
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.31088
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.30106
[BP] GO:0051270 regulation of cellular component movement ALOX12, APP, BCL2, CACNA1C, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, SRC 2.30073
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.27604
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, PPARA, RORC, SRC 2.27393
[BP] GO:0051090 regulation of DNA binding transcription factor activity APP, AR, CYP1B1, ESR1, ESR2, MAP3K7, PIM1, RELA 2.27158
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, FABP3, FLT3, HSD11B2, IGF1R, PPARA, RELA, SRC, TRPV1, TYR 2.27158
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.26566
[BP] GO:1901360 None ACHE, AKR1B1, AKR1B10, ALOX12, AOX1, APP, AR, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAOA, MAP3K7, NR3C1, PPARA, RELA, RORC, TYR, XDH 2.26566
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, RELA 2.26263
[BP] GO:2000026 regulation of multicellular organismal development ALOX12, APP, AR, AXL, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, F3, KDR, MAP2K1, PIM1, PTPRS, RELA, SRC, XDH 2.261
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, RELA 2.25922
[BP] GO:2000209 regulation of anoikis BCL2, MCL1, SRC 2.21838
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.21838
[BP] GO:0019220 regulation of phosphate metabolic process ALOX15, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, PPARA, PTPN1, SRC, XDH 2.21791
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, IGF1R, MCL1, MET, PTPN1, RELA, SRC, XDH 2.21364
[BP] GO:0070213 None TNKS, TNKS2 2.21364
[BP] GO:0006145 None AOX1, XDH 2.21364
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.21364
[BP] GO:0044093 positive regulation of molecular function APP, AR, AURKB, BCL2, CDC25B, ESR1, ESR2, F3, FLT3, MAP2K1, MAP3K7, MET, PTPN1, RELA, SRC, TNKS, XDH 2.21364
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.21062
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, PTGES, RELA, SRC 2.20472
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.20472
[BP] GO:0051174 regulation of phosphorus metabolic process ALOX15, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, PPARA, PTPN1, SRC, XDH 2.19879
[BP] GO:0000122 None AR, AURKB, ESR1, ESR2, ESRRA, MMP12, NR3C1, PPARA, RELA, RORC, TRPV1 2.19503
[BP] GO:0080135 regulation of cellular response to stress APP, CDK6, IGF1R, MAP2K1, MAP3K7, MCL1, MET, PTPN1, PTPRS, XDH 2.19262
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.19262
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CYP1A1, HSD11B2, RELA, SRC, TRPV1, TYR 2.19195
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, PPARA, SRC 2.19195
[BP] GO:0045893 None APP, AR, ESR1, ESR2, ESRRA, ESRRB, MAP2K1, MET, MMP12, NR3C1, PPARA, RELA, RORC, SRC, TNKS 2.18089
[BP] GO:1903508 None APP, AR, ESR1, ESR2, ESRRA, ESRRB, MAP2K1, MET, MMP12, NR3C1, PPARA, RELA, RORC, SRC, TNKS 2.18089
[BP] GO:1902680 None APP, AR, ESR1, ESR2, ESRRA, ESRRB, MAP2K1, MET, MMP12, NR3C1, PPARA, RELA, RORC, SRC, TNKS 2.17906
[BP] GO:1900076 regulation of cellular response to insulin stimulus ESRRA, PTPN1, RELA, SRC 2.15259
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, MCL1, PTPN1, RELA, SRC 2.13478
[BP] GO:0001934 positive regulation of protein phosphorylation ALOX15, APP, AR, BCL2, CDC25B, FLT3, KDR, MAP2K1, MAP3K7, PTPN1, SRC, XDH 2.13478
[BP] GO:0010629 None APP, AR, AURKB, ESR1, ESR2, ESRRA, FABP4, KDR, MAP2K1, MMP12, NR3C1, PPARA, RELA, RORC, SRC, TRPV1, XDH 2.13478
[BP] GO:0051094 positive regulation of developmental process ALOX12, APP, AR, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, KDR, MAP2K1, PIM1, RELA, SRC 2.13071
[BP] GO:0045934 None AR, AURKB, ESR1, ESR2, ESRRA, FABP4, MMP12, NR3C1, PPARA, RELA, RORC, SRC, TNKS, TNKS2, TRPV1 2.1301
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HSD17B3 2.11546
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.11352
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.11352
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 2.10382
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 2.09432
[BP] GO:0051247 positive regulation of protein metabolic process ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, ESR1, F3, FLT3, KDR, MAP2K1, MAP3K7, PTPN1, RELA, SRC, XDH 2.09128
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, PPARA, TRPV1 2.08653
[BP] GO:0010605 negative regulation of macromolecule metabolic process APP, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, IGF1R, KDR, MAP2K1, MMP12, NR3C1, PPARA, PTPN1, RELA, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 2.08283
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.07586
[BP] GO:0010648 negative regulation of cell communication ACHE, AR, BCL2, ESR1, ESR2, IGF1R, MCL1, MET, MMP12, PTPN1, PTPRS, RELA, SRC, XDH 2.07586
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, FABP3, FLT3, HSD11B2, IGF1R, PPARA, RELA, SRC, TRPV1, TYR 2.06683
[BP] GO:0023057 negative regulation of signaling ACHE, AR, BCL2, ESR1, ESR2, IGF1R, MCL1, MET, MMP12, PTPN1, PTPRS, RELA, SRC, XDH 2.06683
[BP] GO:2000145 regulation of cell motility ALOX12, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, SRC 2.06683
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, AR, ESR1, FLT3, IGF1R, NR3C1, RELA, SRC, TRPV1 2.06683
[BP] GO:0043696 None CDK6, ESRRB 2.06683
[BP] GO:0043697 None CDK6, ESRRB 2.06683
[BP] GO:0061370 testosterone biosynthetic process CYP19A1, HSD17B3 2.06683
[BP] GO:0010641 None F3, SRC 2.06683
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.06683
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.06683
[BP] GO:0032868 None FABP3, HSD11B2, PPARA, RELA, SRC 2.05716
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, FLT3, HSD11B2, NR3C1 2.05716
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, PTGES, RELA, SRC 2.04963
[BP] GO:0071383 None AR, FLT3, NR3C1, SRC 2.04063
[BP] GO:0045892 None AR, AURKB, ESR1, ESR2, ESRRA, FABP4, MMP12, NR3C1, PPARA, RELA, RORC, SRC, TRPV1 2.02765
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX12, ALOX15, PTGES 2.0122
[BP] GO:0051254 None APP, AR, ESR1, ESR2, ESRRA, ESRRB, MAP2K1, MET, MMP12, NR3C1, PPARA, RELA, RORC, SRC, TNKS 2.00811
[BP] GO:0030335 positive regulation of cell migration ALOX12, APP, BCL2, F3, IGF1R, KDR, MET, SRC 2.00091
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APP, AR, AURKB, BCL2, CA1, CA2, CA4, CA7, CACNA1C, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, KDR, MAOA, MAP2K1, MAP3K7, MCL1, NR3C1, PIM1, PTGES, PTPN1, PTPRS, RELA, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 4.56332
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.41532
[CC] GO:0043227 membrane-bounded organelle ACHE, AKR1B1, AKR1B10, ALOX12, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA4, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MCL1, MMP12, NR3C1, PIM1, PPARA, PTPN1, PTPRS, RELA, RORC, SHBG, SRC, TNKS, TNKS2, TYR, XDH 3.26924
[CC] GO:0005829 cytosol AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APP, AR, AURKB, BCL2, CA1, CA2, CA7, CBR1, CDC25B, CDK6, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, MAP2K1, MAP3K7, MCL1, NR3C1, PIM1, PTPN1, RELA, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 3.03826
[CC] GO:0043226 organelle ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA4, CACNA1C, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MCL1, MMP12, NR3C1, PIM1, PPARA, PTPN1, PTPRS, RELA, RORC, SHBG, SRC, TNKS, TNKS2, TYR, XDH 2.84737
[CC] GO:0016020 membrane ACHE, ALOX12, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CA12, CA14, CA2, CA4, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MCL1, MET, PIM1, PTGES, PTPN1, PTPRS, SRC, TNKS, TNKS2, TRPV1, TYR 2.76564
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, PTPN1 2.5061
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, GBA2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES 2.21524
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR3C1, PIM1, PPARA, PTPN1, RORC, TNKS, TYR, XDH 14.2348
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP12, NR3C1, PIM1, PPARA, PTGES, PTPN1, PTPRS, RELA, RORC, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 10.8513
[MF] GO:0005496 steroid binding AR, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NR3C1, RORC, SHBG 10.4931
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP12, PIM1, PTGES, PTPN1, PTPRS, SRC, TNKS, TNKS2, TYR, XDH 9.41899
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAOA, TYR, XDH 9.22944
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 8.08723
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, NR3C1, PPARA, RORC, SHBG, TRPV1 7.95977
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 7.60496
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, XDH 7.49981
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 6.91608
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 6.71667
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 6.71667
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MAP3K7, MMP12, NR3C1, PIM1, PPARA, PTPN1, RORC, TNKS, TNKS2, TRPV1, TYR, XDH 5.91367
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MAP3K7, MMP12, NR3C1, PIM1, PPARA, PTPN1, RORC, TNKS, TNKS2, TRPV1, TYR, XDH 5.63853
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 5.529
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, ESR1, ESR2, ESRRA, ESRRB, MMP12, NR3C1, PPARA, PTPN1, RORC, TNKS 5.35453
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.32066
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.07253
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.99716
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.97953
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.85567
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.26649
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 3.9912
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NR3C1, SHBG 3.98151
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B2, HSD17B1, PTGES, SRC, XDH 3.80619
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PPARA, SRC, TRPV1 3.74477
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.73951
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC 3.41276
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.39323
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.29724
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.27373
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.10028
[MF] GO:0043168 anion binding ALOX15, AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PTGES, PTPRS, RELA, SRC, TRPV1, XDH 2.98765
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.95983
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 2.94609
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.82376
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.82376
[MF] GO:0003845 None HSD11B1, HSD11B2 2.82376
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC 2.75629
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 2.71827
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.71827
[MF] GO:0001047 None ESR1, ESR2, ESRRB, MMP12, NR3C1, RELA 2.55047
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, BCL2, CSNK2A1, ESR1, ESR2, FLT3, IGF1R, KDR, MAP3K7, MCL1, MET, RELA, TRPV1, TYR, XDH 2.5001
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC 2.44453
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.44453
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.44453
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.44453
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.43629
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7 2.37869
[MF] GO:0004871 signal transducer activity AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, NR3C1, PPARA, RORC, TRPV1 2.27601
[MF] GO:0038023 signaling receptor activity AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, NR3C1, PPARA, RORC, TRPV1 2.26566
[MF] GO:0000978 None AR, ESR1, ESR2, ESRRA, NR3C1, PPARA, RELA, RORC 2.23848
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.21364
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.21364
[MF] GO:0005497 None AR, SHBG 2.21364
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.21364
[MF] GO:0000987 None AR, ESR1, ESR2, ESRRA, NR3C1, PPARA, RELA, RORC 2.14954
[MF] GO:0060089 molecular transducer activity AR, AXL, CDK6, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, NR3C1, PPARA, RORC, TRPV1 2.13426
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5 2.11352
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5 2.07586
[MF] GO:0019899 enzyme binding APP, AR, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP3A4, ESR1, ESR2, ESRRB, F3, MET, NR3C1, PPARA, PTPN1, RELA, SRC, TNKS2 2.07586
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.06683
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.06683
[MF] GO:0051434 BH3 domain binding BCL2, MCL1 2.06683
[MF] GO:0044877 macromolecular complex binding ACHE, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, PIM1, PPARA, PTPN1, RELA, SRC 2.01455


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP3A4, CYP19A1 12.1487
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MAOA, ALOX15, HSD17B3, AKR1B1, ALOX12, TYR, CYP3A4, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, PTGES 8.6234
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.8735
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 8.9274
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAP2K1, MAOA, ALOX5, ALOX15, ALOX12, CACNA1C 5.4817
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.361
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MAP3K7, MET, IGF1R 5.361
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 5.322
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.2027
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, ALOX12, PTGES 4.4509
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, SRC, ESR1, ESR2, RELA 4.1686
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, CDK6, BCL2, PIM1, CYP1B1, MET, CDC25B, MCL1 4.0188
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 MAP2K1, CDK6, KDR, BCL2, MET, RELA, MCL1, IGF1R 3.6507
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, BCL2, RELA, IGF1R 3.7878
Pathways in cancer_Homo sapiens_hsa05200 AR, MAP2K1, CDK6, FLT3, BCL2, MET, RELA, IGF1R 3.2394
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, SRC, KDR, MET, ESR1, IGF1R 3.2301
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, FLT3, PIM1, RELA 3.3337
Focal adhesion_Homo sapiens_hsa04510 MAP2K1, SRC, KDR, BCL2, MET, IGF1R 3.2301
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, CDK6, SRC, BCL2, RELA 3.0236
Melanoma_Homo sapiens_hsa05218 MAP2K1, CDK6, MET, IGF1R 3.1042
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 3.2111
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP1A2, AOX1, CYP3A4 3.1316
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 BCL2, PIM1, F3, RELA 2.6385
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, SRC, ESR1, ESR2 2.6558
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, MAP2K1, BCL2, CACNA1C 2.5129
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, MAP3K7, RELA 2.743
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, SRC, KDR, MET, IGF1R 2.4122
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, BCL2, RELA, IGF1R 2.6212
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, KDR, MET, RELA, IGF1R 2.2832
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, MAP3K7, RELA 2.427
Apoptosis_Homo sapiens_hsa04210 MAP2K1, BCL2, RELA, MCL1 2.2154
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, MAP3K7, RELA 2.2496
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, CACNA1C, MAP3K7, RELA, CDC25B 2.1644
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1, MCL1 2.1098
Glioma_Homo sapiens_hsa05214 MAP2K1, CDK6, IGF1R 2.1938
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, SRC, KDR 2.2496
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, CDK6, RELA 2.1863
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, RELA, IGF1R 1.9337
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, FLT3, MET 2.1787
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, TYR 2.8167
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, MAP3K7, RELA 1.8077
cAMP signaling pathway_Homo sapiens_hsa04024 MAP2K1, CACNA1C, PPARA, RELA 1.8173
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, CDK6, RELA 2.1139
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 1.8173
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, RELA 2.1711
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, CACNA1C 1.8894
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, CDC25B, IGF1R 1.8173
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2, RELA 1.9404
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.0275
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.1644
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, MAP3K7, RELA 1.7711
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, MAP3K7, RELA 1.7862
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, MAP3K7, RELA 1.7418
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA, RELA 1.7452
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.5364
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, BCL2, RELA 1.6666
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 MAP2K1, SRC, ESR1 1.6724
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.6442
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, BCL2, RELA 1.6666
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, MAP3K7, RELA 1.5743
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, ESRRB, IGF1R 1.5147
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, SRC, CACNA1C 1.4095
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2, RELA 1.3301
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.3094
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC, RELA 1.2179
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, SRC, RELA 1.3094
HTLV-I infection_Homo sapiens_hsa05166 RELA 0.2354
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9834
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3443
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3548
Calcium signaling pathway_Homo sapiens_hsa04020 CACNA1C 0.3396
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, IGF1R 0.9169
AMPK signaling pathway_Homo sapiens_hsa04152 MAP3K7, IGF1R 0.957
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, MAP2K1 0.8959
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8959
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, MAP3K7 0.8841
Hepatitis C_Homo sapiens_hsa05160 PPARA, RELA 0.9169
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, CACNA1C 0.9314
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.957
Melanogenesis_Homo sapiens_hsa04916 MAP2K1, TYR 1.0923
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1 0.4053
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, CACNA1C 0.869
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA, RELA 0.8579
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 0.9735
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 TRPV1, NR3C1 0.5528
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1 0.4248
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA 0.7678
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 MAP2K1, SRC 0.6805
Influenza A_Homo sapiens_hsa05164 MAP2K1, RELA 0.7804
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, CACNA1C 0.803
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.8024
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 RELA, IGF1R 1.1363
Axon guidance_Homo sapiens_hsa04360 MET 0.4435
ErbB signaling pathway_Homo sapiens_hsa04012 MAP2K1, SRC 1.1838
Platelet activation_Homo sapiens_hsa04611 SRC 0.4549
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.4764
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.1838
Gap junction_Homo sapiens_hsa04540 MAP2K1, SRC 1.1838
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 RELA 0.507
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.515
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1 0.515
Amoebiasis_Homo sapiens_hsa05146 RELA 0.515
Long-term potentiation_Homo sapiens_hsa04720 MAP2K1, CACNA1C 1.3449
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1 0.5265
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.524
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, RELA 1.3094
Long-term depression_Homo sapiens_hsa04730 MAP2K1, IGF1R 1.3889
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5229
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C 0.515
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.524
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, MET 1.3449
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.3183
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2611
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1, CDK6 1.4215
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, CACNA1C 1.3381
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1, BCL2 1.3678
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5388
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.536
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.5522
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC, RELA 1.3463
Leishmaniasis_Homo sapiens_hsa05140 MAP3K7, RELA 1.3094
Salmonella infection_Homo sapiens_hsa05132 RELA 0.5445
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.5461
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5373
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.3119
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.4131
Peroxisome_Homo sapiens_hsa04146 XDH 0.5522
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.3183
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.3463
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.5528
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3967
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5583
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5564
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.5522
Pertussis_Homo sapiens_hsa05133 RELA 0.5702
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5724
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1 0.5959
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5724
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5933
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6164
Renin secretion_Homo sapiens_hsa04924 CACNA1C 0.6164
Cocaine addiction_Homo sapiens_hsa05030 MAOA, RELA 1.5196
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.6164
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4 0.6594
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC 1.6423
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.5592
Legionellosis_Homo sapiens_hsa05134 RELA 0.6633
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1 0.6805
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8173
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6836
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.6882
Malaria_Homo sapiens_hsa05144 MET 0.6929
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.6979
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6996
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6979
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6996
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7862
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.7647
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7167
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9834
Prion diseases_Homo sapiens_hsa05020 MAP2K1 0.7983
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.758
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.8576
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1 0.8722
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8374
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8576
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8801
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8474
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8722
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.8976
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 1.0041
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9842
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0586
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0819
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3463


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)