TCM Prescription: Yin Ge Tong Mo Tea



Prescription Description
Prescription IDTCMF7162
Pinyin NameYin Ge Tong Mo Cha
Chinese Name银葛通脉茶
English NameYin Ge Tong Mo Tea
Function Description具有活血, 通脉。用于血脉瘀阻引起的头痛, 头晕及高脂血症等的辅助治疗。
IndicationsHyperlipidemia
Disease ICD-11 Category 5C80.Z [Hyperlipoproteinaemia, unspecified, 高脂蛋白血症，未特指的 ];
Human Tissues Associated with IndicationBrain, Blood, Heart
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2506 Ginkgo biloba 银杏叶 TCMH2506 ITSAJ4779-14
TCMH677 Pueraria lobata 葛根 TCMH677 ITSAJ4206-14
TCMH226 Camellia sinensis 茶叶 TCMH226 ITSAG2924-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT340 GLRA1 Glycine receptor subunit alpha-1 Ion channel P23415
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT578 GLRA2 Glycine receptor subunit alpha-2 Ion channel P23416
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT666 VCP Transitional endoplasmic reticulum ATPase Transporter P55072
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT707 ADORA2A Adenosine A2a receptor GPCR P29274
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT781 CYP2E1 Cytochrome P450 2E1 Oxidoreductase P05181
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, FABP3, GLRA1, HSD17B2, IGF1R, MMP2, MMP9, PPARA, PPARD, RORC, SRC, TYR 9.13139
[BP] GO:0042221 response to chemical ABCB1, ADORA2A, AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, FABP3, FABP4, FLT3, GLRA1, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, PPARD, RORC, SRC, TERT, TYR 8.8999
[BP] GO:0010033 response to organic substance ADORA2A, AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, FABP3, FABP4, FLT3, GLRA1, HSD17B2, IGF1R, KDR, MMP2, PPARA, PPARD, RORC, SRC, TYR 8.7454
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADORA2A, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLRA1, HCAR2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, XDH 8.66939
[BP] GO:0010941 regulation of cell death ADORA1, ADORA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PPARD, PTPN1, SRC, TERT, TOP2A, XDH 8.1894
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADORA2A, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HCAR2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, XDH 8.1894
[BP] GO:0043067 regulation of programmed cell death ADORA1, ADORA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PPARD, PTPN1, SRC, TERT, TOP2A, XDH 8.08889
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, GLRA1, KDR, MMP9, SRC, TERT 8.01066
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA2A, ADORA3, AKR1B1, APP, BCL2, CDC25B, CSNK2A1, CYP1B1, DNMT1, ESR1, ESRRA, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PPARD, SRC, TERT, XDH 7.55921
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADORA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, TYR, XDH 7.53273
[BP] GO:0042981 regulation of apoptotic process ADORA1, ADORA2A, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HCAR2, IGF1R, KDR, MMP9, PIM1, PPARD, PTPN1, SRC, TERT, TOP2A, XDH 7.46392
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP4, FLT3, GLRA1, IGF1R, KDR, MMP2, MMP9, PPARD, RORC, SRC, TERT 6.7963
[BP] GO:0044237 cellular metabolic process ACHE, ADORA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, TYR, XDH 6.7963
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.77082
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GLRA1, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, XDH 6.77005
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD17B1, HSD17B2, PPARD 6.77005
[BP] GO:0060548 negative regulation of cell death ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PPARD, PTPN1, SRC, TERT 6.68302
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, PPARD, RORC, SRC, TYR 6.61436
[BP] GO:0014070 response to organic cyclic compound ADORA2A, ALPL, APEX1, APP, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, RORC, SRC, TYR 6.58639
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CSNK2A1, CYP1A2, DNMT1, ESR1, ESRRA, FABP3, FLT3, GLRA1, IGF1R, MMP2, PPARA, SRC 6.49943
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PIM1, PPARD, PTPN1, SRC, TERT 6.43276
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GLRA1, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, XDH 6.29462
[BP] GO:0032502 developmental process ACHE, ADORA1, ADORA2A, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, ESR1, ESRRA, ESRRB, FABP4, FLT3, GLO1, HSD17B2, KDR, MET, MMP2, MMP9, PIM1, PPARA, PPARD, RORC, SRC, TERT, TOP2A, TYR 6.29351
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, ADORA2A, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, GLRA1, HCAR2, HSD17B1, HSD17B2, KDR, MET, PPARA, PPARD, SRC, TERT, XDH 6.29351
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADORA2A, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PPARD, PTPN1, SRC, TERT, XDH 6.16391
[BP] GO:0023056 positive regulation of signaling ADORA1, ADORA2A, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PPARD, PTPN1, SRC, TERT, XDH 6.14147
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, HSD17B1, HSD17B2, MET, PPARA, PPARD 6.04945
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1B1, DNMT1, ESR1, FABP4, FLT3, GLRA1, IGF1R, KDR, MMP2, PPARD, RORC, SRC 6.00164
[BP] GO:0044281 small molecule metabolic process ADORA2A, AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA, PPARD, TYR, XDH 5.87653
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, PPARD, RORC, SRC 5.81237
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MMP9, PIM1, PPARD, PTPN1, SRC, TERT 5.7307
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.6897
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESRRA, FABP3, FABP4, FLT3, GLRA1, HSD17B2, IGF1R, KDR, MMP12, MMP2, MMP9, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, TYR 5.66793
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADORA2A, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, FLT3, GLRA1, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PPARD, PTPN1, SRC, TERT, XDH 5.60476
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARD, RORC, SRC 5.57417
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADORA2A, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, FLT3, GLRA1, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PPARD, PTPN1, SRC, TERT, XDH 5.49692
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, ADORA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, TYR, XDH 5.47041
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, PPARA, PPARD, SRC, TYR 5.43254
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, FABP4, FLT3, GLRA1, IGF1R, KDR, MMP2, MMP9, PPARD, PTPN1, RORC, SRC, TERT, TOP2A 5.29346
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADORA2A, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, XDH 5.00457
[BP] GO:0009636 response to toxic substance ADORA2A, AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, GLRA1, KDR, SRC 4.8865
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADORA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD17B1, HSD17B2, PPARD 4.84083
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.83168
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADORA2A, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, MMP9, PIM1, PPARA, PPARD, RORC, SRC, TYR 4.83168
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARD, RORC, SRC 4.8135
[BP] GO:0032501 multicellular organismal process ADORA1, ADORA2A, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, FABP4, GLRA1, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, RORC, SRC, TYR 4.8013
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CYP1B1, DNMT1, ESR1, GLRA1, IGF1R, MMP2, MMP9, PPARD, RORC, SRC 4.78234
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, ADORA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, TYR, XDH 4.7517
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA2A, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PPARD, SRC, TERT 4.7517
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADORA2A, APP, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, XDH 4.7306
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA2A, ADORA3, APEX1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PPARD, PTPN1, SRC, TERT 4.69218
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PPARD, SRC, TERT 4.68374
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADORA2A, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, XDH 4.67791
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, PPARA, SRC 4.617
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 4.59384
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.55404
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADORA2A, APEX1, APP, AURKB, BCL2, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PPARD, PTPN1, RORC, SRC, TERT, XDH 4.48813
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.48579
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PPARD, SRC, TERT 4.39942
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, PIM1, SRC 4.38914
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, ESR1, PPARA, RORC, SRC, TOP2A 4.26566
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 4.25116
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, ADORA2A, APP, CYP19A1, DYRK1A, ESR1, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PPARD, PTPN1, SRC, TERT, XDH 4.24338
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, MMP1, MMP12, MMP2, MMP9, PPARD, SRC, XDH 4.17878
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, XDH 4.14973
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PPARD, TERT 4.0665
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADORA2A, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, KDR, MET, MMP12, MMP9, PPARD, PTPN1, SRC, TERT, XDH 4.05044
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PPARD, SRC, TERT 4.02394
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, PPARD, TYR, XDH 4.0193
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, GLRA1, HSD17B2, MMP2, MMP9, PPARD, SRC, TOP2A 4.0193
[BP] GO:0010243 response to organonitrogen compound ADORA2A, AKR1B1, APEX1, APP, DNMT1, FABP3, FLT3, GLRA1, IGF1R, MMP2, PPARA, SRC, TYR 4.0193
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, FABP3, PPARA, PPARD 3.92013
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, GLRA1, MMP9, TERT 3.92013
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, MET, PIM1, PPARD, SRC, TYR 3.88588
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARD, RORC 3.88433
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, FABP3, GLRA1, PPARA, PPARD 3.81396
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ADORA2A, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, MET, PIM1, PPARD, PTPN1, SRC, XDH 3.79229
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.74744
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADORA2A, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, FABP4, FLT3, KDR, MET, MMP12, MMP2, MMP9, PPARD, PTPN1, SRC, TERT, XDH 3.731
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, ADORA2A, APP, AXL, BCL2, CA2, CYP19A1, HCAR2, MMP12, PPARD, SRC, TERT 3.70325
[BP] GO:1901698 response to nitrogen compound ADORA2A, AKR1B1, APEX1, APP, DNMT1, FABP3, FLT3, GLRA1, IGF1R, MMP2, PPARA, SRC, TYR 3.70201
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.70142
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.70142
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC 3.69168
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, ESR1, FLT3, IGF1R, KDR, MET, MMP9, PPARD, PTPN1, SRC, XDH 3.66845
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, ESR1, FLT3, RORC, SRC 3.64974
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, MMP2, PPARA, PPARD, SRC, TERT 3.63808
[BP] GO:0031324 negative regulation of cellular metabolic process ADORA2A, APEX1, APP, AURKB, BCL2, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, IGF1R, MET, MMP12, MMP9, PPARA, PPARD, PTPN1, RORC, SRC, TERT, XDH 3.58714
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADORA2A, BCL2, CYP19A1, DYRK1A, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PPARA, PPARD, PTPN1, SRC, TERT, XDH 3.58714
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, PPARD, SRC, TERT 3.56243
[BP] GO:0006793 phosphorus metabolic process ACHE, ADORA2A, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, MET, PIM1, PPARD, PTPN1, SRC, XDH 3.55926
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, FLT3, IGF1R, KDR, MET, SRC 3.54478
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, PPARD 3.53763
[BP] GO:0044092 negative regulation of molecular function ADORA2A, ADORA3, APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.53763
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, FLT3, IGF1R, KDR, MET, SRC 3.50941
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, GLRA1, KDR 3.50285
[BP] GO:0014910 regulation of smooth muscle cell migration APEX1, BCL2, PPARD, SRC, TERT 3.47907
[BP] GO:0042493 response to drug ABCB1, ADORA2A, AKR1B1, APEX1, AXL, BCL2, CYP1A1, CYP1B1, FABP3, GLRA1, KDR, SRC 3.47907
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MET, SRC, TERT 3.43219
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process ADORA2A, APP, AURKB, DNMT1, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MET, MMP12, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A 3.4179
[BP] GO:0001973 None ADORA1, ADORA2A, ADORA3 3.41133
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADORA2A, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, FLT3, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, PPARD, PTPN1, SRC, TERT, XDH 3.38834
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADORA2A, CA2, CA7 3.34972
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, PPARD, SRC, TERT 3.3374
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARD, RORC 3.31302
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.28111
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.28111
[BP] GO:2000021 regulation of ion homeostasis ADORA1, ADORA2A, BCL2, CA2, CA7, KDR, SRC 3.28111
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, MET, PIM1, SRC 3.20423
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, PPARD, TYR 3.17872
[BP] GO:0040013 None ADORA1, ADORA2A, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, PPARD 3.1698
[BP] GO:0009891 positive regulation of biosynthetic process ADORA2A, APP, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, PPARA, PPARD, RORC, SRC, TERT, TOP2A 3.16893
[BP] GO:0048869 cellular developmental process ACHE, ADORA2A, ALPL, APP, AXL, BCL2, CDC25B, CYP1A1, ESR1, ESRRB, FABP4, FLT3, GLO1, KDR, MET, MMP2, MMP9, PPARD, RORC, SRC, TERT, TOP2A 3.13463
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, ADORA2A, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DYRK1A, ESR1, FLT3, GLO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, SRC, TOP2A, TYR, XDH 3.13081
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, ADORA2A, CA2, CA7 3.11897
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DYRK1A, ESR1, ESR2, GLRA1, IGF1R, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 3.11897
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DYRK1A, ESR1, ESR2, GLRA1, IGF1R, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 3.10549
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 3.07919
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, FABP3, GLRA1, HSD17B2, KDR, MMP2, SRC 3.07842
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AXL, BCL2, CYP1B1, FLT3, KDR, MET, PPARD, PTPN1, SRC, XDH 3.05214
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA2A, ADORA3, APEX1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, XDH 3.04984
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ADORA2A, APP, AXL, BCL2, CA2, CA7, CYP19A1, HCAR2, MMP12, MMP9, PPARA, PPARD, PTPN1, SRC, TERT 3.04101
[BP] GO:0010605 negative regulation of macromolecule metabolic process ADORA2A, APEX1, APP, AURKB, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, IGF1R, KDR, MMP12, MMP9, PPARA, PPARD, PTPN1, RORC, SRC, TERT, XDH 3.04018
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GLRA1, HCAR2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, TYR, XDH 3.03306
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.98131
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADORA2A, CA2, CA7 2.98131
[BP] GO:0051172 None ADORA2A, APEX1, APP, AURKB, CSNK2A1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, IGF1R, MMP12, MMP9, PPARA, PPARD, PTPN1, RORC, SRC, TERT, XDH 2.98021
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA2A, ADORA3, APEX1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, XDH 2.97732
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, MMP2, PPARA, PPARD, SRC, TERT, TYR 2.94947
[BP] GO:0009115 None AOX1, XDH 2.91924
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, MMP9, SRC 2.91924
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 2.91924
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.90158
[BP] GO:0042752 None ADORA1, ADORA2A, PPARA, RORC, TOP2A 2.8152
[BP] GO:0002793 None ACHE, ADORA1, ADORA2A, HCAR2, MMP12, PPARD, SRC 2.8152
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, PPARD, SRC 2.81288
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADORA2A, AURKB, BCL2, CA2, CA7, HCAR2, KDR, SRC 2.79833
[BP] GO:0031348 negative regulation of defense response ADORA1, ADORA2A, CYP19A1, MMP12, PPARA, PPARD 2.78065
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, PPARA, RORC, SRC 2.77119
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.74652
[BP] GO:0031328 positive regulation of cellular biosynthetic process ADORA2A, APP, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MET, MMP12, PPARA, PPARD, RORC, SRC, TERT, TOP2A 2.73389
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, PPARD 2.72428
[BP] GO:0006807 nitrogen compound metabolic process ACHE, ADORA2A, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FLT3, GLO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, TYR, XDH 2.69104
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, PPARA, PPARD 2.68243
[BP] GO:0009966 regulation of signal transduction ADORA1, ADORA2A, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PPARD, PTPN1, SRC, TERT, XDH 2.67333
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GLRA1, HCAR2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, XDH 2.66622
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA2A, ADORA3, APP, AXL, BCL2, CA2, CYP1B1, ESR1, ESRRA, ESRRB, GLRA1, HCAR2, KDR, MET, MMP12, MMP9, PIM1, PPARD, SRC, TERT, XDH 2.66622
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, PPARD 2.66119
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.65728
[BP] GO:0051047 None ACHE, ADORA1, ADORA2A, CYP19A1, HCAR2, MMP12, PPARD, SRC 2.64008
[BP] GO:0051253 None APEX1, AURKB, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, MMP12, PPARA, PPARD, RORC, SRC, TERT 2.60348
[BP] GO:2000146 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, PPARD 2.59627
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADORA2A, APP, BCL2, CDC25B, ESRRB, FABP3, FLT3, KDR, MMP9, PTPN1, SRC, XDH 2.59627
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADORA2A, APP, BCL2, CDC25B, ESRRB, FABP3, FLT3, KDR, MMP9, PTPN1, SRC, XDH 2.59627
[BP] GO:0031347 regulation of defense response ADORA1, ADORA2A, CYP19A1, ESR1, FABP4, MMP12, MMP2, PPARA, PPARD, PTPN1, SRC 2.59164
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, GLRA1, KDR, SRC 2.58517
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DYRK1A, ESR1, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.5564
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.55619
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, GLRA1, IGF1R, MMP2, SRC 2.55619
[BP] GO:0007165 signal transduction ADORA1, ADORA2A, ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CSNK2A1, CYP1B1, DNMT1, ESR1, ESR2, ESRRA, ESRRB, FLT3, GLRA1, HCAR2, IGF1R, KDR, MET, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC 2.55109
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, ADORA2A, CYP19A1, PPARA, PPARD 2.54541
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MET, MMP12, PPARA, PPARD, RORC, SRC, TERT, TOP2A 2.54541
[BP] GO:0046110 None AOX1, XDH 2.5408
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.5408
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.5408
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, MET, PPARA, PPARD 2.51546
[BP] GO:0035588 None ADORA1, ADORA2A, ADORA3 2.51301
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA2A, ADORA3, APEX1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, XDH 2.49086
[BP] GO:0051271 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, PPARD 2.49086
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PPARD 2.49086
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA2A, ADORA3, APEX1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, GLO1, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, XDH 2.48689
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA2A, ADORA3, APEX1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, XDH 2.47312
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADORA2A, APP, CA2, CA7 2.47128
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADORA2A, APP, BCL2, CDC25B, ESRRB, FABP4, FLT3, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.47128
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.46515
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADORA2A, APP, BACE1, CA2, CA7 2.45847
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADORA2A, APP, BACE1, CA2, CA7 2.45847
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.45631
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.45631
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.45556
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, DNMT1, ESR1, FLT3, GLRA1, IGF1R, MMP2, SRC 2.43649
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, PPARD 2.41993
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.41983
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.41983
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.41044
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.40339
[BP] GO:0051240 positive regulation of multicellular organismal process ADORA2A, APP, AXL, BCL2, CA2, CYP1B1, ESRRB, HCAR2, KDR, MET, MMP12, MMP9, PIM1, SRC, TERT 2.39696
[BP] GO:0051881 regulation of mitochondrial membrane potential ADORA2A, BCL2, KDR, SRC 2.3909
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PPARD, TERT 2.38567
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, GLRA1, IGF1R, MMP2, SRC 2.38296
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADORA2A, APP, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.37682
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.37682
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.37535
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA2A, ADORA3, APP, BCL2, CYP1B1, FABP3, PPARD, TERT, XDH 2.35703
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADORA2A, APP, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.34039
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.32701
[BP] GO:0006145 None AOX1, XDH 2.3123
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.3123
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, IGF1R, KDR, MET, MMP9, SRC, TERT 2.30262
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.2892
[BP] GO:0010629 None APP, AURKB, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, KDR, MMP12, PPARA, PPARD, RORC, SRC, TERT, XDH 2.27326
[BP] GO:1901992 positive regulation of mitotic cell cycle phase transition APEX1, APP, CYP1A1, TERT 2.27075
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, MET, SRC, TOP2A 2.27075
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, IGF1R, KDR, MET, MMP9, SRC, TERT 2.21184
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.20859
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, TERT 2.18444
[BP] GO:0050714 None ACHE, ADORA2A, HCAR2, MMP12, PPARD, SRC 2.17403
[BP] GO:0045934 None APEX1, AURKB, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, MMP12, PPARA, PPARD, RORC, SRC, TERT 2.17154
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA2A, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, ESR1, ESR2, FABP4, FLT3, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, XDH 2.15865
[BP] GO:0035587 None ADORA1, ADORA2A, ADORA3 2.15779
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, TERT 2.15345
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, IGF1R, KDR, MET, MMP9, SRC, TERT 2.14385
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, FABP4, GLRA1, MMP9 2.14136
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, IGF1R, PPARA, SRC 2.13547
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GLRA1, HCAR2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, XDH 2.1012
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PPARA, PPARD 2.1012
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.09914
[BP] GO:1903532 None ACHE, ADORA2A, CYP19A1, HCAR2, MMP12, PPARD, SRC 2.09138
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.08587
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.06475
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, IGF1R, KDR, MET, MMP9, SRC, TERT 2.05794
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, PPARD, TYR 2.05024
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ADORA2A, CYP19A1, ESR1, FABP4, KDR, MET, MMP12, PPARA, PPARD 2.03591
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GLRA1, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, TYR, XDH 2.89917
[CC] GO:0099056 None ADORA1, ADORA2A 2.5408
[CC] GO:0098889 None ADORA1, ADORA2A 2.5408
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, ADORA2A, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GLRA1, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, TYR, XDH 2.26881
[CC] GO:0043231 intracellular membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, APEX1, APP, AURKB, BACE1, BCL2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, GLO1, GLRA1, IGF1R, KDR, MMP12, MMP2, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, TYR, XDH 2.15345
[CC] GO:0005783 None ADORA1, APEX1, APP, BCL2, CA4, CYP19A1, FLT3, GLRA1, KDR, PTPN1, XDH 2.04745
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA2A, ADORA3, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CSNK2A1, ESR1, FLT3, GLO1, GLRA1, HCAR2, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SRC, TERT 2.03591
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, GLRA1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, TYR, XDH 17.4179
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GLRA1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, TYR, XDH 11.2207
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, GLRA1, MMP1, MMP12, MMP2, MMP9, PPARA, PPARD, PTPN1, RORC 9.10799
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 8.17591
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, FLT3, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC, TERT, TOP2A, TYR, XDH 8.06452
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, GLRA1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, TERT, TOP2A, TYR, XDH 7.63445
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, GLRA1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, TERT, TOP2A, TYR, XDH 7.26515
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARD, RORC 6.83769
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARD, RORC 6.83769
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARD, RORC 6.43276
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7 5.81237
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.16155
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, GLO1 4.5638
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, FLT3, GLRA1, IGF1R, KDR, MET, PIM1, PPARA, PPARD, SRC, TOP2A 4.55404
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TYR, XDH 4.18445
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1, RORC 4.17878
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA2A, ADORA3, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, GLRA1, HCAR2, IGF1R, KDR, MET, PPARA, PPARD, RORC 3.95306
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.88433
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.81396
[MF] GO:0001609 None ADORA1, ADORA2A, ADORA3 3.70142
[MF] GO:0042802 identical protein binding ACHE, ADORA2A, AOX1, APP, BCL2, CSNK2A1, DYRK1A, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MMP9, TERT, TOP2A, TYR, XDH 3.69376
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.6478
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 3.62234
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.60491
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, FLT3, IGF1R, KDR, MET, SRC 3.60491
[MF] GO:0004872 receptor activity ADORA1, ADORA2A, ADORA3, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, GLRA1, HCAR2, IGF1R, KDR, MET, PPARA, PPARD, RORC 3.38242
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD17B1, HSD17B2, XDH 3.23404
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA2A, ADORA3, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, GLRA1, HCAR2, IGF1R, KDR, MET, PPARA, PPARD, RORC 3.22163
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 3.18948
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.17872
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AOX1, AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, FABP3, FABP4, FLT3, GLRA1, HSD17B1, IGF1R, KDR, MET, PIM1, PPARD, SRC, TOP2A, XDH 3.11897
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HSD17B1, PPARA, PPARD, RORC 3.09784
[MF] GO:0004871 signal transducer activity ADORA1, ADORA2A, ADORA3, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, GLRA1, HCAR2, IGF1R, KDR, MET, PPARA, PPARD, RORC 2.91924
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.91924
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.89938
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.87126
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.86873
[MF] GO:0008134 transcription factor binding APEX1, BCL2, ESR1, ESRRB, FLT3, PIM1, PPARA, PPARD, SRC, TERT 2.86873
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.64624
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.55109
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.51301
[MF] GO:1901363 heterocyclic compound binding ABCB1, ADORA1, AOX1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, IGF1R, KDR, MET, MMP12, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, XDH 2.49086
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.38567
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.3123
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, AOX1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, IGF1R, KDR, MET, MMP12, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TERT, TOP2A, XDH 2.29892
[MF] GO:0035586 None ADORA1, ADORA2A, ADORA3 2.28482
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.26368
[MF] GO:0043565 None APEX1, BCL2, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP12, PPARA, PPARD, RORC, TERT 2.25409
[MF] GO:0005504 None FABP3, FABP4, PPARD 2.19773
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.13189
[MF] GO:0043168 anion binding ABCB1, AOX1, APP, AURKB, AXL, CSNK2A1, DYRK1A, FABP3, FABP4, FLT3, GLRA1, HSD17B1, IGF1R, KDR, MET, PIM1, PPARD, SRC, TOP2A, XDH 2.09351
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, SRC, XDH 2.08415
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.06426
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.05044
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.03402


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.0982
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 9.0958
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.0988
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.3144
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, ABCB1, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 4.3144
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA, PPARD 4.3144
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.3144
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, BCL2, MMP9, MET, IGF1R, PPARD 3.611
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.0325
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 3.8465
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.0325
Metabolic pathways_Homo sapiens_hsa01100 DNMT1, AKR1B1, TYR, CYP19A1, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 3.2474
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.5214
Rap1 signaling pathway_Homo sapiens_hsa04015 ADORA2A, SRC, KDR, MET, IGF1R 2.4646
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1, PPARD 2.2826
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.0443
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.1422
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.0443
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA2A, ADORA1, PPARA 1.7937
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1 1.743
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9119
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1 1.9212
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.5049
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.6156
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GLRA1, ADORA2A, ADORA3, ADORA1 1.4245
Hepatitis B_Homo sapiens_hsa05161 SRC, BCL2, MMP9 1.4245
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.345
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, BCL2, MET, IGF1R 1.2452
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.0832
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3389
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2928
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2452
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3081
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2452
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.0832
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.2452
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0832
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0422
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.2452
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 0.9851
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9851
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.0116
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1787
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.9851
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.6345
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.2452
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.0749
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7331
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5 0.9851
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9694
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.9694
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.8492
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, PPARD 0.8492
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9694
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8511
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6264
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.7642
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.656
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.7642
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6946
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7347
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9069
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2712
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.2711
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.3208
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.331
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3732
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3632
Calcium signaling pathway_Homo sapiens_hsa04020 ADORA2A 0.3628
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3572
Alcoholism_Homo sapiens_hsa05034 ADORA2A 0.3628
Platelet activation_Homo sapiens_hsa04611 SRC 0.4402
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4402
Parkinson's disease_Homo sapiens_hsa05012 ADORA2A 0.4185
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4199
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4225
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4077
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4044
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4597
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3571
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4267
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3924
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4199
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4402
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4402
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5007
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4267
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADORA2A 0.4402
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4402
Axon guidance_Homo sapiens_hsa04360 MET 0.4355
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4872
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4901
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4935
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4872
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5007
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.5007
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5007
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4935
Gap junction_Homo sapiens_hsa04540 SRC 0.5007
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5007
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5007
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4935
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5007
Peroxisome_Homo sapiens_hsa04146 XDH 0.5007
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5384
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5552
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5743
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5743
Glioma_Homo sapiens_hsa05214 IGF1R 0.5743
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5733
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5743
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5743
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5743
Shigellosis_Homo sapiens_hsa05131 SRC 0.5743
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.5743
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6286
Malaria_Homo sapiens_hsa05144 MET 0.6392
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6445
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6419
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6474
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6536
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.6505
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6803
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7742
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7469
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7742
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7667
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7902
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0669
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9851
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2452


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)