TCM Prescription: Wei Fu Shu Capsules



Prescription Description
Prescription IDTCMF7061
Pinyin NameWei Fu Shu Jiao Nang
Chinese Name胃复舒胶囊
English NameWei Fu Shu Capsules
Function Description理气消胀, 清热和胃。用于寒热错杂所致的胃胀, 痞满疼痛, 嗳气吞酸, 食欲减退, 慢性浅表性胃炎见上述证候者。
IndicationsEpigastric distension disorder, Tangled cold and heat pattern
Disease ICD-11 Category SA52 [Epigastric distension disorder (TM1), 胃胀 (TM1) ];
SE7A [Tangled cold and heat pattern (TM1), 寒热错杂证 (TM1) ];
Human Tissues Associated with Indication
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2640 Valeriana jatamansii 蜘蛛香 TCMH2640
TCMH130 Pinellia ternata 半夏 TCMH130 GBVT1123-13, GBVY1693-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
TCMH1632 Taraxacum mongolicum 蒲公英 TCMH1632 ITSAG679-14
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH972 Coptis chinensis 黄连 TCMH972 ITSAO4469-14
TCMH182 Areca catechu 槟榔 TCMH182 ITSAA732-14
TCMH160 Piper cubeba 毕澄茄 TCMH160 MH493317
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT601 F2 Thrombin Unclassified P00734
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.2529
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.3368
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 11.2587
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, GBA2, GLO1, HMGCR, PIM1, PPARA, TBXAS1, TYR, XDH 10.3148
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 9.99533
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA, TBXAS1 9.90214
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA3, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FABP3, HMGCR, HSD11B2, HSD17B2, IGF1R, MMP2, MMP9, POLB, PPARA, SRC, TYR 9.34781
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CHRM1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, ESR1, F2, F3, FABP3, FABP4, FLT3, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MET, POLA1, POLB, PPARA, SRC, TERT, TNKS, TNKS2, XDH 8.71988
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 8.47958
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD17B2, KDR, MET, MMP2, MMP9, PIM1, POLB, PPARA, PTPRS, SRC, TERT, TNKS2, TOP2A, TYR 8.14675
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA3, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, POLB, PPARA, SRC, TYR 8.02302
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA3, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, MMP9, POLB, PPARA, SRC, TERT, TYR 7.74933
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.74698
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 6.63532
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC, TERT 6.46944
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, ESR1, ESRRA, F2, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, SRC, TERT, XDH 6.39884
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F2, F3, FLT3, HMGCR, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.34565
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F2, F3, FLT3, HMGCR, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.32073
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 6.10448
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.05511
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 5.99184
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, SRC, TYR 5.68166
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FLT3, HSD11B2, SRC, TYR 5.64904
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, BCL2, CA3, CA9, CDK6, CYP1A1, CYP1B1, DRD1, FABP3, HMGCR, HSD11B2, KDR, POLB, SRC 5.57231
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.55423
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CA3, CYP1A1, CYP1B1, DRD1, HMGCR, KDR, POLB, SRC 5.3874
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, SRC 5.30447
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, GBA2, HMGCR, TYR 5.25708
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, ESR1, F2, F3, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, TERT 5.24676
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA3, CA6, CA9, CDK6, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, F2, F3, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, IGF1R, KDR, MMP12, MMP2, MMP9, POLA1, POLB, PPARA, PTPN1, SRC, TERT, TOP2A, TYR 5.23789
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 5.23147
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, BCL2, CDK6, CHRM1, CHRM4, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 5.23147
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.22955
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TOP2A, XDH 5.15389
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 5.11452
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TERT, TOP2A, XDH 5.09382
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, ESRRB, F2, FLT3, GBA2, HSD11B1, HSD17B2, KDR, MMP9, PIM1, POLB, PPARA, PTPRS, SRC, TYR 5.0521
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 4.86423
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, POLB, PPARA, PTPRS, SRC, TYR 4.86423
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, GBA2, HMGCR, MET, PPARA, TBXAS1 4.78884
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.78784
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, PPARA, SRC 4.71545
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 4.71545
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, DRD1, F2, HMGCR, KDR, SRC, TNKS, TNKS2 4.7125
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT, TOP2A, XDH 4.58664
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 4.57099
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, F2, F3, FLT3, HMGCR, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.5546
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA3, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, HMGCR, IGF1R, KDR, MET, PIM1, POLB, PTPN1, PTPRS, SRC, TNKS, XDH 4.4595
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.42592
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 4.39464
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 4.32412
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA7, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1B1, DRD1, F2, F3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SRC, TERT 4.29354
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT 4.22853
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 4.21046
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.13094
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA3, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, HMGCR, IGF1R, KDR, MET, PIM1, POLB, PTPN1, PTPRS, SRC, TNKS, XDH 4.13094
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, SRC, TERT 4.09433
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, DRD1, ESR1, F2, FABP3, FABP4, FLT3, MET, POLA1, POLB, SRC, TERT 4.05582
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TERT 4.05582
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CHRM1, CHRM4, CYP1A1, ESR1, FLT3, MET, PIM1, POLA1, SRC, TYR 4.05582
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 3.96343
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 3.90509
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, POLA1, POLB, PTPN1, SRC, TERT, TOP2A 3.79245
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 3.79228
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD1, ESR1, F2, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLB, PPARA, PTPN1, PTPRS, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 3.78896
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CHRM1, CYP19A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRB, F2, F3, FABP4, HMGCR, HSD11B2, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SRC, TNKS2, TYR 3.78896
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F2, F3, FABP4, FLT3, HMGCR, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 3.7217
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CDK6, CYP19A1, ESR1, F2, F3, FABP4, HMGCR, IGF1R, MET, MMP12, MMP2, PPARA, PTPN1, PTPRS, SRC, TERT, XDH 3.62914
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, F2, F3, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 3.55344
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 3.53788
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, BCL2, CDK6, CYP19A1, DRD1, ESR1, ESR2, F2, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, PTPRS, SRC, TERT, XDH 3.53788
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, SRC 3.53788
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 3.50457
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, F2, F3, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 3.50457
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT 3.50457
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GLO1, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.50166
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, F2, F3, FLT3, HMGCR, KDR, MET, PTPN1, SRC, XDH 3.49753
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.47329
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 3.44627
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, F2, KDR, SRC 3.40321
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.37492
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, HMGCR, HSD11B2, MMP2, POLB, PPARA, SRC, TERT, TYR 3.37267
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, F2, F3, FABP4, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 3.35617
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.31671
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, POLB, PPARA, SRC, TERT 3.29724
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, TBXAS1 3.2406
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 3.23616
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 3.2289
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, GLO1, PPARA, TBXAS1 3.20095
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.13764
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 3.09991
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.05989
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.05989
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.05756
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.04371
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, TERT 3.03403
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.00808
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC 2.96447
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 2.95421
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GLO1, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.95421
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, ESRRB, F2, FABP3, FLT3, HMGCR, KDR, MMP9, PTPN1, SRC, XDH 2.95026
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, ESRRB, F2, FABP3, FLT3, HMGCR, KDR, MMP9, PTPN1, SRC, XDH 2.95026
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F2, F3, FLT3, HMGCR, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 2.93964
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 2.93614
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.93614
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, DRD1, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, KDR, MET, MMP2, MMP9, PTPRS, SRC, TERT, TOP2A 2.92861
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, F2, PPARA 2.91554
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 2.90809
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, GBA2, MMP1, MMP12, MMP2, MMP9, SRC, XDH 2.90282
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR 2.88594
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC, TERT 2.84038
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CA3, CYP1B1, MMP9, SRC 2.84038
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT, TNKS 2.84038
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 2.78801
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR 2.78026
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, SRC 2.77203
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC, TERT 2.76049
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, TERT 2.70859
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.7049
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.7049
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, ESR1, F2, F3, FABP4, HMGCR, KDR, MET, MMP12, PPARA, PTPRS 2.7049
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 2.70413
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 2.6854
[BP] GO:0009115 None AOX1, XDH 2.67275
[BP] GO:0006286 base-excision repair, base-free sugar-phosphate removal APEX1, POLB 2.67275
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.63934
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, DRD1, KDR, SRC 2.62978
[BP] GO:0016311 None ALPL, APEX1, BCL2, CA3, CDC25B, POLB, PTPN1, PTPRS 2.6103
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 2.60723
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA3, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, F2, HSD11B2, MMP2, MMP9, POLA1, POLB, PPARA, PTPN1, SRC, TERT, TOP2A 2.54868
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.54868
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.54424
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, ESR1, ESRRB, HSD11B2, HSD17B2, MMP2, MMP9, SRC, TOP2A 2.5258
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, ESRRB, F2, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.52049
[BP] GO:0032845 None ADORA1, BCL2, HMGCR, SRC, TNKS, TNKS2 2.50022
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 2.49316
[BP] GO:0007200 None CHRM1, CHRM2, CHRM4, DRD1, ESR1 2.48266
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.47278
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CHRM1, CYP19A1, DRD1, F2, MMP12, SRC, TERT 2.46341
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.39341
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.39341
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CHRM1, CYP19A1, DRD1, F2, HMGCR, MMP12, MMP9, PPARA, PTPN1, SRC, TERT 2.37989
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, F2, TNKS, TNKS2 2.37881
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CYP1B1, ESR1, ESRRA, ESRRB, F2, F3, HMGCR, KDR, MET, MMP12, MMP9, PIM1, PTPRS, SRC, TERT, TNKS2, XDH 2.36856
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, GLO1, PIM1, PPARA, TBXAS1, TYR 2.36523
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, ESRRB, F2, FLT3, HMGCR, KDR, MMP9, PTPN1, SRC, XDH 2.36028
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CYP1A1, HMGCR, POLB, TERT 2.33217
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.33109
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DRD1, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, TERT, XDH 2.28678
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, F2, FLT3, IGF1R, KDR, MET, SRC, TNKS, TOP2A 2.28678
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CDK6, CYP1B1, DRD1, ESR1, IGF1R, MMP2, MMP9, SRC 2.28678
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, ESRRB, F2, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.28678
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DRD1, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, TERT, XDH 2.28678
[BP] GO:0098502 DNA dephosphorylation APEX1, POLB 2.28678
[BP] GO:0046110 None AOX1, XDH 2.28678
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.28678
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.28144
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX15, CYP19A1, CYP3A4, HMGCR, TYR 2.28144
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1 2.27212
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 2.27077
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DRD1, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, SRC, TYR 2.26824
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, ESRRB, F2, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.26045
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.22039
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.22039
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.19809
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, F2, F3, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 2.1964
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, PIM1, TERT, TNKS, TOP2A 2.1737
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.13902
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.1056
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, IGF1R, KDR, MET, MMP12, PPARA, SRC, TERT, TNKS, TNKS2, TOP2A 2.09966
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, HSD11B2, IGF1R, PPARA, SRC 2.09966
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.05287
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.05287
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4 2.04861
[BP] GO:0070213 None TNKS, TNKS2 2.04861
[BP] GO:0006145 None AOX1, XDH 2.04861
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.04861
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.04101
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.03089
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, F2, FLT3, HMGCR, KDR, MMP9, PTPN1, SRC, XDH 2.03089
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, GLO1, PIM1, PPARA, TBXAS1, TYR 2.02355
[BP] GO:0095500 None CHRM1, CHRM2, CHRM4 2.01942
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.01942
[BP] GO:1903831 None CHRM1, CHRM2, CHRM4 2.01942
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.01932
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, F2, FABP3, FLT3, HMGCR, PPARA, SRC 2.0185
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.0185
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DRD1, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, SRC, TYR 2.0185
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, F2, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 2.01759
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, APP, AURKB, BCL2, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, F2, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MMP2, MMP9, PIM1, POLA1, PTPN1, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.98841
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 2.77932
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, F2, FLT3, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTPN1, TBXAS1 2.75224
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CBR1, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 2.47466
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, F2, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TYR 2.1737
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, TBXAS1 2.12768
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 19.1842
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, TBXAS1, TNKS, TYR, XDH 18.9015
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F2, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PTPN1, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 17.2556
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 14.4992
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 13.9205
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.1999
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1, POLB 10.3949
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 9.44588
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, TNKS 9.07431
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F2, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 8.47958
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 8.14675
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 6.78812
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, XDH 6.20445
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.94191
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.9014
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 4.6971
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.68371
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD11B2, HSD17B1, POLA1, SRC, TBXAS1, XDH 4.64958
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, TYR 4.44448
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA 3.89941
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 3.79228
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC, TOP2A 3.71291
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC, TBXAS1 3.68661
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 3.61927
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC, TBXAS1 3.50457
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.48465
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.48465
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, TYR 3.23616
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.13764
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.13666
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.05165
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.04402
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.03594
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, IGF1R, KDR, MET, PPARA 2.95026
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, CHRM1, CHRM2, CHRM4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, IGF1R, KDR, MET, PPARA 2.68359
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.67275
[MF] GO:0003845 None HSD11B1, HSD11B2 2.67275
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.65614
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.45169
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, IGF1R, KDR, MET, PPARA 2.37192
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.36529
[MF] GO:0016788 None ACHE, ADORA1, ALPL, APEX1, CA1, CA2, CA3, CDC25B, CHRM1, POLA1, PTPN1, PTPRS 2.28678
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.28678
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.28144
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.16139
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.12377
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.11615
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.05287
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.04861
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.04861
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.04861


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 20.5722
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 10.0664
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.3567
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, HMGCR, TYR, CYP3A4, GBA2, CYP19A1, HSD11B1, POLA1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 6.6196
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.9352
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.7133
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 3.5842
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.669
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, ABCB1, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 3.5683
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.5683
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM1, CHRM4, BCL2 3.086
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 3.2887
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.5683
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, BCL2, MMP9, MET, IGF1R 2.9223
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM1, ADORA3, CHRM4, ADORA1, DRD1, F2 3
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, TBXAS1 3
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, CHRM1, KDR, BCL2, MET, IGF1R 2.6142
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 2.9602
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.3833
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.9223
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, HMGCR, CYP3A4 2.9076
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, CHRM1, ADORA1, DRD1, PPARA 2.1825
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.1713
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM1, SRC, CHRM4, F2 2.0775
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 1.8778
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 1.8703
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.8677
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1, CYP3A4 1.8778
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.6253
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.4588
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3, DRD1 1.6503
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15 1.4588
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.2033
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 2.8735
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.3884
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.1503
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM1, DRD1 1.0397
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, CDK6, SRC 0.9307
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 0.8735
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.177
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.1724
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.1118
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.1503
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 0.9274
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.9248
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.8887
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.096
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 0.9389
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.9248
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 0.9996
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.1539
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.8324
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 0.8642
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.0926
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.7844
Complement and coagulation cascades_Homo sapiens_hsa04610 F2, F3 0.9978
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 0.9151
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.7844
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.7937
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.7937
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7937
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 0.7844
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.7305
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.7844
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.7169
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7258
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.622
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.601
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.5981
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.5507
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.1985
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.3186
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2811
HTLV-I infection_Homo sapiens_hsa05166 POLB, TERT 0.4582
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3023
Alcoholism_Homo sapiens_hsa05034 DRD1 0.2879
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2809
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3023
Parkinson's disease_Homo sapiens_hsa05012 DRD1 0.3386
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3386
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3284
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3251
Phagosome_Homo sapiens_hsa04145 TUBB3 0.322
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3386
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.317
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3386
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.347
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.347
Axon guidance_Homo sapiens_hsa04360 MET 0.3524
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3598
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.3647
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1 0.3505
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.5859
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3913
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4143
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4143
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4041
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4179
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.492
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4219
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4218
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4346
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4217
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.434
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4346
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4346
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4343
Peroxisome_Homo sapiens_hsa04146 XDH 0.4447
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.4806
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4795
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5436
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.4798
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4924
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5025
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5025
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5025
Base excision repair_Homo sapiens_hsa03410 POLB, APEX1 1.5297
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.501
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4939
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5025
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5136
Shigellosis_Homo sapiens_hsa05131 SRC 0.5025
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5053
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.5358
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.5385
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.7734
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.5589
Malaria_Homo sapiens_hsa05144 MET 0.5701
Cocaine addiction_Homo sapiens_hsa05030 DRD1 0.5701
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5725
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5701
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.5725
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.6174
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.5891
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6123
DNA replication_Homo sapiens_hsa03030 POLA1 0.6394
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6949
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7169
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7342
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7298
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.7844
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.8324
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9048
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.9223
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.1503


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)