TCM Prescription: Feng Re Gan Mao Granules



Prescription Description
Prescription IDTCMF7010
Pinyin NameFeng Re Gan Mao Ke Li
Chinese Name风热感冒颗粒
English NameFeng Re Gan Mao Granules
Function Description疏风清热, 利咽解毒。用于风热感冒, 发热, 有汗, 鼻塞, 头痛, 咽痛, 咳嗽, 多痰。
IndicationsCommon cold disorder, Common cold
Disease ICD-11 Category SA60 [Common cold disorder (TM1), 感冒 (TM1) ];
CA00 [Acute nasopharyngitis, 急性鼻咽炎 ];
Human Tissues Associated with IndicationLung, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH127 Isatis indigotica 板蓝根 TCMH127 KJ765825
TCMH1272 Forsythia suspensa 连翘 TCMH1272 ITSAJ4444-14
TCMH188 Mentha haplocalyx 薄荷 TCMH188 HM595443
TCMH1142 Schizonepetae spica 荆芥穗 TCMH1142
TCMH1797 Morus alba 桑叶 TCMH1797 ITSAL1073-14
TCMH1339 Phragmites communis 芦根 TCMH1339 KT695247
TCMH1562 Arctium lappa 牛蒡子 TCMH1562 ITSAI1776-14
TCMH1181 Chrysanthemum morifolium 菊花 TCMH1181 KX675020
TCMH1219 Semen armeniacae amarum 苦杏仁 TCMH1219
TCMH1798 Morus alba 桑枝 TCMH1798 ITSAL1073-14
TCMH1307 Massa medicata fermentata 六神曲 TCMH1307
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT118 MGAM Maltase-glucoamylase Hydrolase O43451
TCMT124 FUCA1 Alpha-L-fucosidase I Hydrolase P04066
TCMT125 GBA Beta-glucocerebrosidase Hydrolase P04062
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT347 MAN1B1 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase Hydrolase Q9UKM7
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT588 DAO D-amino-acid oxidase Oxidoreductase P14920
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT884 PHF8 Histone lysine demethylase PHF8 Oxidoreductase Q9UPP1
TCMT965 KDM7A Lysine-specific demethylase 7 Oxidoreductase Q6ZMT4


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1241 Human rhinovirus 14
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1321 Staphylococcus hominis
TCMT1333 Human rhinovirus 1A
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GSK3B, HIF1A, HMGCR, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PHF8, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 14.1304
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GSK3B, HIF1A, HMGCR, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MGAM, MMP1, MMP2, NQO2, NUAK1, PHF8, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 13.7532
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, EGFR, ESR1, FABP3, FABP4, FLT3, GBA, GSK3B, HIF1A, HMGCR, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MMP2, PIK3CA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 13.2802
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, EGFR, ESR1, FABP3, GBA, GSK3B, HMGCR, HSD17B2, IDO1, IGF1R, INSR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC, TEK, TYR 12.9111
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, EGFR, ESR1, FABP3, FABP4, FLT3, GBA, GSK3B, HIF1A, HMGCR, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MMP2, MMP9, PIK3CA, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TYR 12.727
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GBA, GPR35, GSK3B, HIF1A, HMGCR, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 12.5873
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GBA, GPR35, GSK3B, HIF1A, HMGCR, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 12.5813
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, EGFR, ESR1, FABP3, FABP4, FLT3, GAA, GBA, GPR35, GSK3B, HIF1A, HMGCR, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, KIT, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 12.1108
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, GSK3B, HIF1A, HMGCR, HSPA1A, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 11.9901
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DNMT1, EGFR, ESR1, FABP3, FLT3, HIF1A, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, TERT, XDH 11.9901
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GBA, GLO1, GSK3B, HIF1A, HMGCR, HSPA1A, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 11.9825
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GBA, GLO1, GSK3B, HIF1A, HMGCR, HSPA1A, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 11.86
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, GSK3B, HIF1A, HMGCR, HSPA1A, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 11.8441
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, FABP3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HMGCR, HSPA1A, IDO1, PIK3CA, PIM1, PTGS1, PTGS2, TYR, XDH 11.4792
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, ESR1, FABP3, FABP4, FUCA1, FUT7, GBA, HMGCR, HSD17B1, HSD17B2, KIT, MET, PIK3CA, PIK3CB, PTGS1, PTGS2 11.2498
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GSK3B, HIF1A, HMGCR, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NUAK1, PHF8, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 10.7047
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, FABP4, FLT3, GBA, GSK3B, HIF1A, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, PIK3CA, PTGS2, RORC, SMAD3, SRC, TERT 10.7047
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, GSK3B, HIF1A, HMGCR, HSPA1A, IDO1, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 10.5684
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, DYRK1A, EGFR, ESR1, FABP4, FLT3, FUT7, GAA, GBA, GLO1, GSK3B, HIF1A, HMGCR, HSD17B2, INSR, KDR, KIT, MET, MMP2, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TNKS2, TOP2A, TYR 10.5541
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, GSK3B, HIF1A, HMGCR, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 10.5405
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FLT3, GBA, GPR35, GSK3B, HIF1A, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 10.5405
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, GBA, GPR35, GSK3B, HIF1A, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 10.3978
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, GSK3B, HIF1A, HMGCR, HSPA1A, IDO1, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 10.2349
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, GAA, GSK3B, HMGCR, HSD17B1, HSD17B2, IDO1, NQO2, PHF8, PTGS1, PTGS2, TYR, XDH 9.82701
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GSK3B, HIF1A, HMGCR, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NUAK1, PHF8, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 9.59033
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DNMT1, EGFR, ESR1, FABP4, FLT3, GBA, GSK3B, HIF1A, IGF1R, INSR, KDR, KIT, MMP2, PIK3CA, PTGS2, RORC, SMAD3, SRC 9.59033
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CDK6, CYP19A1, DHFR, DUSP3, DYRK1A, EGFR, ESR1, FABP4, GBA, GSK3B, HIF1A, HMGCR, HSPA1A, IDO1, IGF1R, MET, MMP12, MMP2, NUAK1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 9.38076
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, GBA, GPR35, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 9.38076
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, GBA, GPR35, GSK3B, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 9.38076
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, HIF1A, KDR, KIT, MMP9, PTGS2, SRC, TERT 9.37626
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, EGFR, ESR1, FABP4, FLT3, GBA, GSK3B, HIF1A, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, NUAK1, PIK3CA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A 9.3401
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DHFR, DUSP3, DYRK1A, EGFR, FLT3, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TEK, TNKS, XDH 9.31612
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, GBA, GPR35, GSK3B, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 9.24488
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, EGFR, ESR1, FABP3, FLT3, GBA, GSK3B, IGF1R, INSR, KIT, MMP2, PTGS2, SMAD3, SRC, TEK 9.09956
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DAO, DHFR, DUSP3, DYRK1A, EGFR, ESR1, FLT3, FUCA1, FUT7, GBA, GLO1, GSK3B, HIF1A, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PHF8, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 9.08743
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, KIT, PIM1, SRC, TEK 8.98284
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FABP4, FLT3, GPR35, GSK3B, HIF1A, HMGCR, HSPA1A, IDO1, INSR, KDR, KIT, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 8.873
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DHFR, DUSP3, DYRK1A, EGFR, FLT3, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TEK, TNKS, XDH 8.8315
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, GBA, GLO1, GPR35, GSK3B, HIF1A, HMGCR, HSPA1A, IDO1, IGF1R, KDR, KIT, MET, MMP12, MMP9, PHF8, PIK3CA, PIM1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 8.8315
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, GBA, HSD17B2, IDO1, PTGS2, RORC, SRC, TYR 8.14817
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, FLT3, GBA, PTGS2, RORC, SRC, TEK, TYR 8.10343
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, EGFR, ESR1, FABP3, FABP4, FLT3, GBA, GSK3B, HIF1A, HMGCR, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR 8.10307
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DHFR, DUSP3, DYRK1A, EGFR, ESR1, FABP4, FLT3, GBA, GPR35, GSK3B, HIF1A, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 8.08879
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, HIF1A, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 8.04575
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIM1, SRC, TEK, TNKS 7.8766
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, HIF1A, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 7.66795
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, FUCA1, FUT7, GBA, HMGCR, KIT, MET, PIK3CA, PIK3CB, PTGS1, PTGS2 7.65481
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, FABP4, FLT3, GBA, GSK3B, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 7.60575
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AXL, BCL2, CYP1B1, EGFR, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, KIT, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 7.56739
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, ESR1, FLT3, HIF1A, HMGCR, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK, TERT 7.51725
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, HIF1A, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 7.47067
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, HIF1A, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 7.45112
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, GBA, GPR35, GSK3B, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 7.43827
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, FLT3, GBA, GSK3B, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 7.43744
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9, DHFR 7.30122
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, GBA, GLO1, GPR35, GSK3B, HIF1A, HMGCR, HSPA1A, IDO1, IGF1R, KDR, KIT, MET, MMP12, MMP9, PHF8, PIK3CA, PIM1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 7.28994
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DHFR, DNMT1, DYRK1A, EGFR, ESR1, FABP3, FLT3, GBA, GSK3B, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 7.28382
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, FABP3, FABP4, FUCA1, FUT7, GAA, GBA, GSK3B, HSPA1A, IDO1, MGAM, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 7.28382
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, FLT3, GAA, GBA, GPR35, HIF1A, INSR, MET, PIK3CA, PIK3CB, SMAD3, SRC, TERT 7.18294
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, GBA, INSR, KIT, PTGS2, SRC, TEK 7.11523
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TNKS 7.08407
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ESR1, FABP3, FLT3, GBA, GSK3B, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 7.02626
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, FLT3, GBA, GSK3B, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 6.96613
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 6.95237
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 6.88406
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, EGFR, HIF1A, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.86271
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, APEX1, APP, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPR35, GSK3B, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 6.83843
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, HMGCR, HSD17B1, HSD17B2 6.81972
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.75493
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP4, GAA, GBA, HIF1A, HMGCR, HSD17B2, IDO1, IGF1R, INSR, KIT, MET, MGAM, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PTGS2, RORC, SMAD3, SRC, TEK, TNKS2, TYR 6.73247
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, BCL2, CDC25B, EGFR, FABP3, FLT3, GBA, HIF1A, HMGCR, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.73247
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, BCL2, CDC25B, EGFR, FABP3, FLT3, GBA, HIF1A, HMGCR, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.73247
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, EGFR, HIF1A, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.69384
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, EGFR, HIF1A, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.54264
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, FABP4, FLT3, GBA, GPR35, GSK3B, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KIT, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 6.50814
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, EGFR, HIF1A, HMGCR, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 6.50234
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, FLT3, GBA, GSK3B, HMGCR, HSPA1A, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.46294
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, DYRK1A, EGFR, ESR1, FLT3, GAA, GSK3B, HIF1A, HSD17B2, INSR, KDR, KIT, MMP9, PHF8, PIK3CA, PIM1, PTGS2, RORC, SMAD3, SRC, TEK, TYR 6.44533
[BP] GO:0080135 regulation of cellular response to stress APP, CDK6, DHFR, DUSP3, DYRK1A, EGFR, GSK3B, HIF1A, HMGCR, HSPA1A, IGF1R, MET, NUAK1, PTGS2, PTPN1, TERT, XDH 6.4372
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, EGFR, HIF1A, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.37088
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.36427
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DAO, DHFR, GBA, HIF1A, HMGCR, TYR 6.34189
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CDK6, CYP1B1, DNMT1, EGFR, ESR1, GSK3B, IGF1R, INSR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC 6.33691
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DUSP3, DYRK1A, EGFR, ESR1, GBA, GPR35, GSK3B, HIF1A, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 6.3287
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, BCL2, DNMT1, ESR1, GBA, GSK3B, HIF1A, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 6.31617
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DUSP3, DYRK1A, EGFR, ESR1, GBA, GPR35, GSK3B, HIF1A, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 6.31152
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ESR1, FLT3, GBA, GSK3B, HMGCR, HSPA1A, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.30224
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TEK 6.27871
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HIF1A, HSD17B2, INSR, KDR, KIT, PHF8, PIK3CA, SMAD3, SRC, TEK, TYR 6.23549
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, DYRK1A, ESR1, GBA, HIF1A, HMGCR, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 6.09489
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, GBA, HIF1A, HMGCR, HSPA1A, KIT, MMP2, PTGS2, SMAD3, SRC, TEK, TERT, TYR 5.99908
[BP] GO:0010638 positive regulation of organelle organization AURKB, BCL2, DNMT1, GBA, GSK3B, HIF1A, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 5.96414
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, GBA, GSK3B, HMGCR, IGF1R, INSR, KIT, PIK3CA, PIK3CB, PTPN1, SRC, TEK, TNKS 5.92713
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, GBA, HIF1A, HMGCR, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.92494
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CDK6, CYP19A1, DUSP3, DYRK1A, EGFR, ESR1, GBA, GSK3B, HIF1A, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.90013
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, APP, AURKB, BCL2, CDC25B, DHFR, EGFR, ESR1, FLT3, GSK3B, HIF1A, HSPA1A, INSR, KIT, MET, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 5.89595
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, GBA, HIF1A, HMGCR, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.86702
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, BCL2, CDC25B, DNMT1, DUSP3, DYRK1A, EGFR, FABP4, FLT3, GBA, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 5.77322
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, HIF1A, KIT, MMP9, PTGS2, TERT 5.75399
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, DHFR, EGFR, FABP3, GBA, HMGCR, KDR, PTGS2, SRC 5.74383
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, GBA, GSK3B, HIF1A, HSPA1A, IDO1, KIT, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A 5.717
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, GSK3B, KDR, PIK3CB, SMAD3, SRC, TEK 5.65975
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, BCL2, CDC25B, DHFR, EGFR, ESR1, FLT3, GSK3B, HIF1A, HSPA1A, INSR, KIT, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 5.60338
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT, TNKS, TOP2A 5.60338
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, KIT, MET, PIK3CA, PIK3CB, SRC, TEK 5.56159
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.5102
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, BCL2, CA2, CDK6, CYP1B1, EGFR, ESR1, GAA, GBA, GPR35, GSK3B, HIF1A, HMGCR, HSPA1A, IDO1, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIM1, PTGS2, SMAD3, SRC, TEK, TERT, TNKS2, XDH 5.50584
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, GBA, HMGCR, IGF1R, INSR, KIT, PIK3CB, PTPN1, SRC 5.48764
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 5.48669
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, INSR, KIT, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 5.47169
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, FLT3, GBA, HMGCR, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 5.4613
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC 5.45828
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, EGFR, FLT3, HIF1A, HMGCR, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 5.41976
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, EGFR, ESR1, GSK3B, KIT, RORC, SRC, TOP2A 5.30612
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GPR35, GSK3B, HIF1A, HMGCR, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PHF8, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 5.30415
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, APP, AURKB, BCL2, CSNK2A1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP4, GBA, GSK3B, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 5.29866
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTGS2, TERT 5.29821
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, DHFR, EGFR, HIF1A, INSR, PTGS2, SMAD3, XDH 5.21209
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GBA, HIF1A, HMGCR, IGF1R, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 5.20434
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GBA, HMGCR, IGF1R, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 5.20053
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, DUSP3, EGFR, FLT3, GBA, HMGCR, IGF1R, INSR, KDR, KIT, PIK3CB, PTPN1, SRC, TEK, XDH 5.14909
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GBA, GPR35, GSK3B, HMGCR, IGF1R, MET, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS 5.03472
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP4, FLT3, GBA, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.02919
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GBA, GPR35, HIF1A, INSR, MET, PIK3CA, PIK3CB, SMAD3 5.00935
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, EGFR, FLT3, HMGCR, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.99839
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, GBA, HMGCR, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 4.9627
[BP] GO:0009968 negative regulation of signal transduction BCL2, DUSP3, DYRK1A, EGFR, ESR1, GBA, GSK3B, HIF1A, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 4.9432
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GBA, HMGCR, IGF1R, INSR, KIT, PIK3CA, PIK3CB, PTPN1, SRC, TEK 4.93954
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUCA1, FUT7, GAA, HSPA1A, KIT, MGAM, MMP9, PIK3CA, PIK3CB, RORC, SMAD3, SRC 4.93047
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 4.91915
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, KIT, MET, PIK3CB, PIM1, SRC, TEK, TYR 4.90477
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.85141
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DHFR, DNMT1, EGFR, FABP3, FLT3, GSK3B, IGF1R, INSR, MMP2, PTGS2, SRC, TEK, TYR 4.85005
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DYRK1A, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, KIT, MET, SRC, TEK, TNKS, TOP2A 4.76067
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HIF1A, MMP2, PTGS2, SMAD3, SRC, TEK, TERT 4.73184
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP4, FLT3, GBA, GLO1, GSK3B, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PHF8, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 4.7287
[BP] GO:0051128 regulation of cellular component organization APP, AURKB, AXL, BCL2, CSNK2A1, DNMT1, EGFR, ESR1, GBA, GSK3B, HIF1A, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, PHF8, PIK3CB, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 4.71057
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HIF1A, HSPA1A, MMP9, PTGS2, PTPN1, SRC 4.70569
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, EGFR, ESR1, FABP4, FLT3, FUT7, GLO1, GSK3B, HIF1A, HMGCR, KDR, KIT, MET, MMP2, MMP9, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TOP2A 4.70569
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, DNMT1, EGFR, ESR1, FLT3, GSK3B, IGF1R, INSR, KIT, MMP2, PTGS2, SMAD3, SRC 4.69239
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, GBA, GLO1, GSK3B, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PHF8, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 4.69128
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GBA, HMGCR, IGF1R, INSR, KIT, PIK3CA, PIK3CB, PTPN1, SRC 4.65756
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.65523
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, APP, AURKB, BCL2, CSNK2A1, DHFR, DNMT1, DUSP3, DYRK1A, ESR1, FABP4, GBA, GSK3B, HIF1A, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PIK3CA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 4.65221
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HIF1A, MMP2, PTGS2, SMAD3, SRC, TEK, TERT 4.63409
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUCA1, GBA 4.59397
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, HIF1A, HMGCR, HSD17B1, HSD17B2 4.59152
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, EGFR, FLT3, HMGCR, INSR, KDR, KIT, PIK3CB, PTPN1, SRC, TEK, XDH 4.57441
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, FUCA1, FUT7, GBA, GLO1, GSK3B, HIF1A, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PHF8, PIK3CA, PIM1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 4.55755
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, FUT7, GSK3B, HIF1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP2, NUAK1, PHF8, PIK3CA, PIM1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 4.5561
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, RORC, SRC 4.50478
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CYP1B1, EGFR, GBA, HIF1A, HMGCR, HSPA1A, IDO1, KDR, KIT, MET, MMP12, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK, TERT 4.49794
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.47546
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.47465
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DHFR, DNMT1, EGFR, FABP3, FLT3, GSK3B, IGF1R, INSR, MMP2, PTGS2, SRC, TEK, TYR 4.46082
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, GBA, GLO1, GSK3B, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PHF8, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 4.45803
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PTGS2, SMAD3, SRC, TERT, TNKS, TOP2A 4.44193
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, EGFR, HSPA1A, IDO1 4.4376
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, FABP3, FABP4, FUCA1, FUT7, GAA, GBA, GSK3B, HSPA1A, IDO1, MGAM, XDH 4.4171
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.37896
[BP] GO:0051246 regulation of protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP4, FLT3, GBA, GSK3B, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.34074
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HIF1A, MMP2, PTGS2, SMAD3, SRC, TEK, TERT 4.33541
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, CYP19A1, CYP3A4, DAO, DHFR, GBA, HMGCR, TYR 4.3284
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CA7, CYP19A1, EGFR, GPR35, GSK3B, HIF1A, HMGCR, HSPA1A, INSR, MMP12, MMP9, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TERT 4.30562
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR, IDO1 4.30119
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, GBA, GLO1, GSK3B, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PHF8, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 4.30119
[BP] GO:0043412 macromolecule modification ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, FUT7, GSK3B, HIF1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PHF8, PIK3CA, PIM1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 4.30119
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, HIF1A, PIK3CB, PTGS2, TNKS, TNKS2 4.28822
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, EGFR, GSK3B, HIF1A, INSR, MMP12, PTGS2, SMAD3, SRC, TERT 4.2821
[BP] GO:0006464 cellular protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, FUT7, GSK3B, HIF1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PHF8, PIK3CA, PIM1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 4.27366
[BP] GO:0036211 protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, FUT7, GSK3B, HIF1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PHF8, PIK3CA, PIM1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 4.27366
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, EGFR, FLT3, GPR35, GSK3B, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 4.26788
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, NQO2, PTGS1, RORC 4.2507
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, GBA, GLO1, GSK3B, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PHF8, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 4.1991
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, HIF1A, HSD17B2, IDO1, INSR, KIT, MMP2, MMP9, PTGS2, SRC, TOP2A 4.14041
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 4.12383
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, APP, AURKB, CSNK2A1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP4, GBA, GSK3B, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, MMP12, MMP9, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 4.07375
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, EGFR, GSK3B, IGF1R, INSR, MMP2, PTGS2, SRC 4.06418
[BP] GO:0016137 None AKR1B1, AKR1B10, FUCA1, GBA 4.05893
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, GBA, HSPA1A, IDO1, MMP12, MMP2, PTGS2, PTPN1, SMAD3, SRC, TEK 4.00677
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, HMGCR 4.00157
[BP] GO:0010634 positive regulation of epithelial cell migration HIF1A, KDR, MET, MMP9, PTGS2, SRC, TEK 4.00157
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC, TEK 3.99797
[BP] GO:0001101 response to acid chemical AKR1B1, DHFR, DNMT1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 3.98627
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, FUT7, GSK3B, HIF1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PHF8, PIK3CA, PIM1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.9585
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTGS2, TERT 3.93985
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, FABP3, FABP4, FUCA1, GAA, GBA, GSK3B, HSPA1A, IDO1, MGAM, PIK3CB, SRC, XDH 3.93813
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, BCL2, CSNK2A1, EGFR, GBA, GSK3B, HIF1A, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PTPN1, SMAD3 3.91497
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, GSK3B, KDR, SMAD3, TEK 3.91068
[BP] GO:0010810 regulation of cell-substrate adhesion BCL2, CDK6, GSK3B, KDR, PIK3CB, SMAD3, SRC, TEK 3.9014
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, GBA, HMGCR, IGF1R, INSR, KIT, PIK3CB, PTPN1, SRC 3.89884
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, HIF1A, HSD17B2, INSR, KIT, PTGS2, SRC 3.89287
[BP] GO:0001816 cytokine production APP, FABP4, HIF1A, IDO1, KIT, PTGS2 3.88271
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.82534
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.81018
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, GSK3B, MET, MMP9, SMAD3, SRC, TERT, TNKS 3.76727
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, EGFR, GSK3B, IGF1R, INSR, MMP2, PTGS2, SRC 3.76651
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, GSK3B, IGF1R, INSR, PTGS2, SRC, TEK 3.70346
[BP] GO:0044283 None AKR1B1, ALOX5, CYP19A1, CYP1A1, CYP3A4, DHFR, GBA, HMGCR, IDO1, PTGS1, PTGS2 3.66373
[BP] GO:0033043 regulation of organelle organization AURKB, BCL2, DNMT1, GBA, GSK3B, HIF1A, HSPA1A, INSR, KDR, MET, MMP9, PHF8, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.64814
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, GSK3B, MET, MMP9, SRC, TERT 3.644
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, DUSP3, INSR, TERT 3.63213
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DAO, DHFR, FABP3, GLO1, HIF1A, IDO1, PIM1, PTGS1, PTGS2, TYR 3.58604
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.58048
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, HIF1A, MET, SMAD3, SRC 3.5757
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, EGFR, KDR, PTGS2, SRC 3.5757
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HMGCR, KIT, PTGS2, RORC, SRC, TEK 3.57011
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, HIF1A, HSPA1A, MMP9, PTGS2, PTPN1, SRC, TERT 3.56661
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, EGFR, HIF1A, HMGCR, KIT, PTGS2, TYR 3.54506
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, DNMT1, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 3.53965
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, SRC, TERT 3.49334
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, KIT, MMP9, TERT 3.47949
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, GBA, PTGS2, SRC 3.45999
[BP] GO:0030154 cell differentiation ALPL, AXL, BCL2, CBR1, CDK6, CYP1A1, ESR1, FABP4, FLT3, FUT7, GLO1, GSK3B, HIF1A, HMGCR, KDR, KIT, MMP2, MMP9, PTGS2, RORC, SMAD3, TOP2A 3.45999
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 3.45705
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, GBA, PTGS2, SRC 3.45227
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 3.45227
[BP] GO:0033554 cellular response to stress AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, DHFR, EGFR, GBA, GSK3B, HIF1A, HSPA1A, MMP9, NUAK1, PTGS2, PTPN1, SRC, TERT, TOP2A 3.44467
[BP] GO:0002682 regulation of immune system process ADORA1, APP, AXL, BCL2, CA2, CDK6, CYP19A1, DUSP3, ESR1, HIF1A, HSPA1A, IDO1, KIT, MMP12, MMP2, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC 3.4377
[BP] GO:0030155 regulation of cell adhesion BCL2, CDK6, CYP1B1, DUSP3, GSK3B, IDO1, KDR, NUAK1, PIK3CA, PIK3CB, SMAD3, SRC, TEK 3.4273
[BP] GO:2001233 regulation of apoptotic signaling pathway BCL2, GSK3B, HIF1A, HSPA1A, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT 3.41269
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.40859
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HIF1A, HSPA1A, MMP9, PTGS2, PTPN1, SRC 3.40859
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, ESR1, FABP4, GBA, HMGCR, IDO1, KDR, MET, MMP12, PTGS2, SMAD3, TEK 3.39585
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.39405
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4, PHF8 3.39405
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BACE1, CA2, CA7, EGFR, KIT, PTGS2 3.38828
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BACE1, CA2, CA7, EGFR, KIT, PTGS2 3.38828
[BP] GO:0050793 regulation of developmental process APP, AXL, BCL2, CA2, CDK6, CYP1B1, EGFR, ESR1, GSK3B, HIF1A, HMGCR, IDO1, INSR, KDR, KIT, NUAK1, PIK3CA, PIM1, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TNKS2, XDH 3.37959
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, HIF1A, IDO1, PTGS1, PTGS2 3.36175
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, GBA, IDO1, PTGS2, SMAD3, TEK 3.35886
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, GAA, GBA, GLO1, GPR35, GSK3B, HIF1A, HMGCR, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PHF8, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 3.33908
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, FLT3, INSR, KIT, PIK3CA, PIK3CB, PTPN1, SRC, TEK, TNKS 3.3369
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 3.33445
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 3.32146
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.30265
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, HIF1A, KDR, KIT, TEK, TYR 3.27678
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 3.2481
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, HMGCR, KDR, SRC 3.24553
[BP] GO:2001251 None DNMT1, PHF8, SRC, TNKS, TNKS2, TOP2A 3.24553
[BP] GO:0051172 None APEX1, APP, AURKB, CSNK2A1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP4, GBA, HMGCR, HSPA1A, IGF1R, MMP12, MMP9, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 3.24553
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, BCL2, CDK6, CYP1B1, FABP3, HSPA1A, IDO1, PTGS2, SMAD3, TERT, XDH 3.2384
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.20248
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.20248
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 3.20248
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.18931
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, GSK3B, HMGCR, IDO1, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH 3.17134
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, HIF1A, KDR, KIT, PTGS2, TEK, TERT 3.16699
[BP] GO:2000026 regulation of multicellular organismal development APP, AXL, BCL2, CA2, CDK6, CYP1B1, EGFR, ESR1, GSK3B, HIF1A, HMGCR, IDO1, INSR, KDR, KIT, PIM1, PTGS2, SMAD3, SRC, TEK, TERT, XDH 3.16114
[BP] GO:0043436 oxoacid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DAO, DHFR, FABP3, GLO1, HIF1A, IDO1, PIM1, PTGS1, PTGS2, TYR 3.15901
[BP] GO:0010564 regulation of cell cycle process APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, EGFR, HSPA1A, INSR, TERT, TNKS 3.14979
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, GSK3B, HMGCR, IDO1, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH 3.13565
[BP] GO:0016477 cell migration AXL, CYP1B1, EGFR, FUT7, HIF1A, KDR, KIT, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 3.13414
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, DHFR, EGFR, SMAD3 3.1121
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC, TEK 3.10688
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.08721
[BP] GO:0019371 None CBR1, PTGS1, PTGS2 3.08721
[BP] GO:0006082 organic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DAO, DHFR, FABP3, GLO1, HIF1A, IDO1, PIM1, PTGS1, PTGS2, TYR 3.08149
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR, PTGS2 3.06183
[BP] GO:0001525 angiogenesis CYP1B1, HIF1A, KDR, MMP2, PIK3CA, PIK3CB, PTGS2, TEK 3.05025
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC, TEK 3.03361
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.03361
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PTGS2, SRC, TEK 3.02657
[BP] GO:0051241 negative regulation of multicellular organismal process ADORA1, APP, AXL, BCL2, CDK6, EGFR, GBA, GPR35, GSK3B, HIF1A, IDO1, PTGS2, SMAD3, TEK, TERT, XDH 3.02646
[BP] GO:1901215 negative regulation of neuron death AXL, BCL2, GBA, GSK3B, HIF1A, PIK3CA, TERT 3.02098
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, EGFR, GBA, HMGCR, PTGS2, SRC, TYR 3.01715
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, KIT, MMP9, RORC 2.99895
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, EGFR, ESR1, FABP3, GBA, HIF1A, IGF1R, INSR, KDR, MET, MMP12, PHF8, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 2.98538
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HMGCR, HSD17B1, HSD17B2 2.97752
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, INSR, KIT, PIK3CB, PTPN1, SRC 2.96976
[BP] GO:0051248 None APP, CSNK2A1, DHFR, DNMT1, DUSP3, EGFR, FABP4, GBA, HMGCR, HSPA1A, IGF1R, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH 2.9221
[BP] GO:0051094 positive regulation of developmental process APP, AXL, BCL2, CA2, CYP1B1, HIF1A, HMGCR, IDO1, INSR, KDR, KIT, PIM1, PTGS2, SMAD3, SRC, TEK, TERT 2.91012
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PTGS2, SMAD3, SRC, TERT 2.90812
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, KIT, SRC 2.90733
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, ESR1, HIF1A, MET, SMAD3, SRC 2.90189
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, FLT3, INSR, KIT, PIK3CA, PIK3CB, PTPN1, SRC, TEK 2.89933
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, DYRK1A, GSK3B, TNKS 2.88944
[BP] GO:0050890 None ADORA1, APP, EGFR, HIF1A, HMGCR, INSR, KIT, PTGS2 2.88944
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.88533
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade APP, DUSP3, EGFR, HMGCR, KDR, PTPN1, SRC, TEK 2.86916
[BP] GO:0010942 positive regulation of cell death BCL2, CYP1B1, GSK3B, HMGCR, IDO1, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH 2.85752
[BP] GO:0006066 None AKR1B1, AKR1B10, APP, CYP1B1, CYP3A4, DHFR, GBA, HMGCR 2.84905
[BP] GO:0040011 locomotion AXL, CYP1B1, EGFR, FUT7, HIF1A, KDR, KIT, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.81765
[BP] GO:0032963 collagen metabolic process HIF1A, MMP1, MMP12, MMP2, MMP9 2.81765
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, DHFR, EGFR, FLT3 2.81374
[BP] GO:0007612 None APP, HIF1A, HMGCR, INSR, KIT, PTGS2 2.81374
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, GPR35, HIF1A, PIK3CB, SMAD3 2.81374
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HIF1A, IDO1, PIK3CB 2.79798
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.79798
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.79637
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, DNMT1, EGFR, ESR1, HIF1A, HSPA1A, IGF1R, INSR, MET, MMP12, PHF8, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 2.79637
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.78166
[BP] GO:0046173 None AKR1B1, CYP3A4, DHFR, GBA 2.78166
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.78166
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, GBA, PTGS2 2.77227
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.75819
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, GSK3B, IGF1R, INSR, SRC 2.75644
[BP] GO:0048870 cell motility AXL, CYP1B1, EGFR, FUT7, HIF1A, KDR, KIT, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.74541
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, DYRK1A, GSK3B, TNKS 2.73809
[BP] GO:0010595 positive regulation of endothelial cell migration HIF1A, KDR, MET, PTGS2, TEK 2.73809
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.71589
[BP] GO:0044259 multicellular organismal macromolecule metabolic process HIF1A, MMP1, MMP12, MMP2, MMP9 2.71589
[BP] GO:0001961 None AXL, HIF1A, HSPA1A, MMP12 2.71295
[BP] GO:0043551 regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 2.71295
[BP] GO:0009653 anatomical structure morphogenesis APP, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, ESR1, GAA, GBA, HIF1A, INSR, MET, MMP2, SMAD3, SRC, TEK 2.70461
[BP] GO:0032845 None ADORA1, BCL2, HMGCR, SRC, TNKS, TNKS2 2.7001
[BP] GO:0035239 tube morphogenesis BCL2, EGFR, ESR1, HIF1A, MET, SMAD3, SRC 2.68154
[BP] GO:0010632 regulation of epithelial cell migration HIF1A, KDR, MET, MMP9, PTGS2, SRC, TEK 2.68154
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH 2.68154
[BP] GO:0050999 None DHFR, EGFR, HIF1A, TERT 2.68154
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, EGFR, GSK3B, HIF1A, HMGCR, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.67904
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PTGS1, PTGS2 2.67342
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH 2.67292
[BP] GO:0046165 None AKR1B1, CYP3A4, DHFR, GBA, HMGCR 2.66138
[BP] GO:0030097 hemopoiesis FLT3, HIF1A, KDR, KIT, TEK 2.66138
[BP] GO:0051052 regulation of DNA metabolic process AURKB, DNMT1, EGFR, IGF1R, INSR, PIK3CA, SRC, TNKS, TNKS2 2.65393
[BP] GO:0044089 positive regulation of cellular component biogenesis ESR1, GSK3B, HSPA1A, KDR, KIT, MET, MMP1, SMAD3, SRC, TEK 2.65343
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.65343
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.65343
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.65343
[BP] GO:0070920 None EGFR, ESR1, TERT 2.65343
[BP] GO:0048546 None BCL2, EGFR, HIF1A 2.65343
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, XDH 2.64811
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, EGFR, ESR1, FABP3, GBA, HIF1A, IGF1R, INSR, MET, MMP12, PHF8, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 2.63473
[BP] GO:1900180 regulation of protein localization to nucleus APP, EGFR, GSK3B, PTGS2, SMAD3, SRC, TERT 2.62436
[BP] GO:2000107 negative regulation of leukocyte apoptotic process AURKB, AXL, HIF1A, IDO1 2.58817
[BP] GO:0060760 None AXL, HIF1A, HSPA1A, MMP12 2.58817
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.57819
[BP] GO:0010821 regulation of mitochondrion organization BCL2, GBA, GSK3B, HIF1A, HSPA1A, KDR, MMP9 2.56726
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, HIF1A, KDR, PTGS2, TEK, TERT 2.56726
[BP] GO:0008542 None APP, HIF1A, HMGCR, KIT 2.55615
[BP] GO:0003018 None ADORA1, EGFR, HMGCR, PTGS2, SRC, TEK 2.55376
[BP] GO:0045321 leukocyte activation ALOX5, AXL, BCL2, FLT3, FUCA1, FUT7, GAA, HSPA1A, KIT, MGAM, MMP9, RORC, SMAD3 2.54843
[BP] GO:0051129 negative regulation of cellular component organization APP, DNMT1, GBA, GSK3B, HSPA1A, MET, PHF8, SRC, TNKS, TNKS2, TOP2A 2.54452
[BP] GO:0000023 None GAA, MGAM 2.54452
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.54452
[BP] GO:0046486 glycerolipid metabolic process ACHE, CSNK2A1, EGFR, FABP3, FABP4, KIT, MET, PIK3CA, PIK3CB 2.54452
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AURKB, EGFR, ESR1, GBA, HIF1A, IGF1R, INSR, KDR, MET, MMP12, PHF8, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 2.54065
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CYP1A1, EGFR, GBA, HMGCR, PTGS2, SRC, TYR 2.53837
[BP] GO:0032147 activation of protein kinase activity ADORA1, EGFR, INSR, KIT, PIK3CA, PIK3CB, PTPN1, SRC 2.52674
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, KIT, PTPN1, SRC 2.52325
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CYP1A1, HMGCR, PTGS2, TERT 2.52325
[BP] GO:0051000 None DHFR, HIF1A, TERT 2.51859
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, KDR, KIT, TEK 2.51676
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, DNMT1, EGFR, GSK3B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PTPN1, SRC, TEK 2.50004
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, GAA, GBA, GLO1, GPR35, GSK3B, HIF1A, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PHF8, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 2.48526
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, EGFR, FLT3, INSR, KIT, PIK3CA, PIK3CB, PTPN1, SRC 2.48506
[BP] GO:0007611 None APP, EGFR, HIF1A, HMGCR, INSR, KIT, PTGS2 2.48255
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, EGFR, GSK3B, HIF1A, MMP12, PTGS2, SMAD3, SRC 2.48166
[BP] GO:0033138 positive regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, PIK3CA, PTGS2 2.48166
[BP] GO:0046854 phosphatidylinositol phosphorylation EGFR, KIT, MET, PIK3CA, PIK3CB 2.48166
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 2.47131
[BP] GO:0009889 regulation of biosynthetic process ADORA3, APEX1, APP, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DHFR, DNMT1, EGFR, ESR1, FABP3, FABP4, GBA, GLO1, GSK3B, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, PHF8, PIM1, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 2.46103
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.45875
[BP] GO:0035162 embryonic hemopoiesis HIF1A, KDR, KIT 2.45875
[BP] GO:0002252 None ALOX5, APP, BCL2, FUCA1, FUT7, GAA, HSPA1A, KIT, MGAM, MMP9, PIK3CA, PIK3CB, RORC, SRC 2.45592
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3 2.45589
[BP] GO:0010639 None DNMT1, HSPA1A, MET, PHF8, SRC, TNKS, TNKS2, TOP2A 2.45589
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.45589
[BP] GO:0043550 regulation of lipid kinase activity FLT3, KIT, SRC, TEK 2.45589
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, EGFR, GBA, HMGCR, IDO1, KIT, MMP12, PTGS2, SMAD3, SRC, TYR 2.45589
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.45589
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.45589
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.45589
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.45589
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DYRK1A, GSK3B, SRC, TNKS 2.44226
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.43801
[BP] GO:0009314 response to radiation APP, AURKB, BCL2, EGFR, HIF1A, HMGCR, KIT, PTGS2, TYR 2.43305
[BP] GO:0007632 None APP, HIF1A, HMGCR, KIT 2.43009
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.43009
[BP] GO:0030258 lipid modification CYP1A1, CYP3A4, EGFR, KIT, MET, PIK3CA, PIK3CB 2.4165
[BP] GO:0050678 None CDK6, EGFR, HIF1A, KDR, MMP12, SMAD3, TEK, XDH 2.41046
[BP] GO:0071456 cellular response to hypoxia BCL2, HIF1A, PTGS2, SRC, TERT 2.40392
[BP] GO:1901342 regulation of vasculature development CYP1B1, HIF1A, KDR, KIT, PTGS2, TEK, TERT, XDH 2.40392
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.40392
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.40392
[BP] GO:0010822 positive regulation of mitochondrion organization BCL2, GBA, GSK3B, HIF1A, KDR, MMP9 2.3955
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, GPR35, HIF1A, PIK3CB, SMAD3 2.39304
[BP] GO:0032768 None DHFR, EGFR, HIF1A, TERT 2.37639
[BP] GO:0044236 multicellular organism metabolic process HIF1A, MMP1, MMP12, MMP2, MMP9 2.37316
[BP] GO:0010811 positive regulation of cell-substrate adhesion CDK6, GSK3B, KDR, SMAD3, TEK 2.37316
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, GBA, MMP12, SMAD3, TEK 2.37307
[BP] GO:0006091 generation of precursor metabolites and energy AKR1B1, CYP19A1, CYP1A2, GAA, GSK3B, IDO1, NQO2, XDH 2.36766
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.36101
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.35628
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.35628
[BP] GO:0007610 None APP, BCL2, EGFR, GAA, HIF1A, HMGCR, IDO1, INSR, KIT, PTGS2 2.35093
[BP] GO:0044242 None AKR1B10, CYP1B1, FABP3, FABP4, FUCA1, GBA 2.35093
[BP] GO:0008406 gonad development BCL2, CYP19A1, ESR1, INSR, KIT 2.34226
[BP] GO:0040008 regulation of growth APP, BCL2, CSNK2A1, EGFR, HIF1A, HSPA1A, INSR, PIK3CA, PIM1, SMAD3, TNKS2 2.34007
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.32772
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.32772
[BP] GO:0032880 regulation of protein localization ACHE, APP, BCL2, CSNK2A1, EGFR, GSK3B, HIF1A, HMGCR, MMP12, PTGS2, PTPN1, SMAD3, SRC, TERT 2.32007
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DHFR, EGFR, INSR, PTGS2, SMAD3 2.31341
[BP] GO:1901987 None APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, EGFR, TERT 2.31341
[BP] GO:0098908 None GBA, GPR35 2.31341
[BP] GO:0070213 None TNKS, TNKS2 2.31341
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.31341
[BP] GO:0060969 None ESR1, PHF8, TERT 2.31247
[BP] GO:1902895 None HIF1A, SMAD3, TERT 2.31247
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.31247
[BP] GO:0036294 cellular response to decreased oxygen levels BCL2, HIF1A, PTGS2, SRC, TERT 2.30346
[BP] GO:0046834 lipid phosphorylation EGFR, KIT, MET, PIK3CA, PIK3CB 2.30346
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, GBA, SRC 2.30225
[BP] GO:0009896 positive regulation of catabolic process CSNK2A1, GBA, GSK3B, HIF1A, HSPA1A, INSR, KDR, PIK3CB, PTPN1 2.29833
[BP] GO:0031329 regulation of cellular catabolic process APEX1, BCL2, GBA, GSK3B, HIF1A, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PTPN1 2.29298
[BP] GO:0019725 cellular homeostasis APEX1, APP, BCL2, CA2, CA7, ESR1, GAA, GPR35, HIF1A, PIK3CA, PIK3CB, SMAD3 2.2783
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, GBA, GLO1, GPR35, GSK3B, HIF1A, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PHF8, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 2.26602
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, FLT3, INSR, KIT, PIK3CB, PTPN1, SRC 2.26602
[BP] GO:0050900 leukocyte migration FUT7, KIT, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.26602
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.26385
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.26385
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.26385
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DAO, GBA 2.25828
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, GBA, SMAD3, TEK 2.24427
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.24127
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DYRK1A, GSK3B, SRC, TNKS 2.23759
[BP] GO:0051894 None KDR, SMAD3, TEK 2.21553
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.21553
[BP] GO:0060249 None AKR1B1, APEX1, BCL2, GAA, HIF1A, SRC, TERT 2.21553
[BP] GO:0010468 regulation of gene expression ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDK6, CSNK2A1, CYP1A2, CYP1B1, DHFR, DNMT1, DYRK1A, EGFR, ESR1, FABP4, GLO1, GSK3B, HIF1A, HSPA1A, INSR, KDR, KIT, MET, MMP12, PHF8, PIK3CA, PIK3CB, PIM1, RORC, SMAD3, SRC, TERT, TNKS, TOP2A, XDH 2.21096
[BP] GO:0002376 immune system process ALOX5, APP, AXL, BCL2, FLT3, FUCA1, FUT7, GAA, HIF1A, HSPA1A, IDO1, IGF1R, KIT, MGAM, MMP1, MMP9, PIK3CA, PIK3CB, RORC, SMAD3, SRC, TEK 2.2069
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, GBA, MET, PIK3CA 2.20084
[BP] GO:0032269 None APP, CSNK2A1, DHFR, DNMT1, DUSP3, FABP4, GBA, HMGCR, HSPA1A, IGF1R, MMP9, PTGS2, PTPN1, SRC, XDH 2.20084
[BP] GO:0030098 lymphocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, RORC 2.19696
[BP] GO:0005975 None AKR1B1, FUCA1, FUT7, GAA, GLO1, GSK3B, INSR, MGAM, PIK3CA 2.18614
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.17374
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.17372
[BP] GO:0032770 None DHFR, HIF1A, TERT 2.17372
[BP] GO:0090068 positive regulation of cell cycle process APEX1, APP, AURKB, CDC25B, CYP1A1, INSR, TERT 2.16045
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.15261
[BP] GO:0007584 response to nutrient ALPL, CYP1A1, EGFR, HMGCR, PTGS2, TYR 2.14421
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, IDO1, PTGS2, SRC 2.13673
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.13673
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, DNMT1, EGFR, ESR1, FLT3, GPR35, GSK3B, HIF1A, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2 2.13673
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling FLT3, KDR, KIT, TEK 2.13673
[BP] GO:0046466 None CYP1B1, FUCA1, GBA 2.13673
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.13673
[BP] GO:0097066 None AKR1B1, GBA, KIT 2.13673
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.13673
[BP] GO:1903393 None KDR, SMAD3, TEK 2.13673
[BP] GO:0051186 None AKR1B1, AKR1B10, CYP1A1, CYP1A2, DHFR, EGFR, GLO1, HMGCR, PTGS2 2.13614
[BP] GO:1901214 regulation of neuron death AXL, BCL2, GBA, GSK3B, HIF1A, PIK3CA, TERT 2.13614
[BP] GO:0070201 None ACHE, APP, BCL2, EGFR, GSK3B, HIF1A, HMGCR, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.13176
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, FABP4, IDO1, KDR, MET, PTGS2, SMAD3 2.12901
[BP] GO:0051348 None DUSP3, FABP4, GBA, GSK3B, HMGCR, IGF1R, PTPN1, SRC 2.12848
[BP] GO:0014910 regulation of smooth muscle cell migration APEX1, BCL2, SRC, TERT 2.11955
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, PIK3CA, TNKS2 2.11955
[BP] GO:0034097 response to cytokine AXL, BCL2, FABP4, FLT3, GBA, GSK3B, HIF1A, PTGS2, SRC 2.11532
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade APP, EGFR, HMGCR, KDR, SRC, TEK 2.11386
[BP] GO:0010628 positive regulation of gene expression APP, DNMT1, EGFR, ESR1, GSK3B, HIF1A, HSPA1A, INSR, KIT, MET, MMP12, PHF8, PIK3CB, RORC, SMAD3, SRC, TERT, TNKS, TOP2A 2.10247
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, EGFR, GSK3B, HIF1A, MMP12, PTGS2, SMAD3, SRC 2.10054
[BP] GO:0010575 positive regulation of vascular endothelial growth factor production CYP1B1, HIF1A, PTGS2 2.10054
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.10054
[BP] GO:1904646 cellular response to amyloid-beta APP, GSK3B, IGF1R 2.10054
[BP] GO:0071453 cellular response to oxygen levels BCL2, HIF1A, PTGS2, SRC, TERT 2.08798
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CYP1B1, EGFR, FUT7, HIF1A, KDR, KIT, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK 2.08698
[BP] GO:0051704 multi-organism process APP, AXL, BCL2, CDK6, CYP1A1, DYRK1A, EGFR, HSPA1A, IDO1, INSR, KDR, MET, MMP1, MMP12, SMAD3, SRC 2.08063
[BP] GO:0003008 None ADORA1, AKR1B1, APP, BCL2, CYP1B1, EGFR, GAA, HIF1A, HMGCR, INSR, KIT, PIK3CA, PTGS2, SRC, TEK, TYR 2.07786
[BP] GO:1901992 positive regulation of mitotic cell cycle phase transition APEX1, APP, CYP1A1, TERT 2.05892
[BP] GO:0071634 None HIF1A, PTGS2, SMAD3 2.05892
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.05892
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, GSK3B, IDO1, MMP12, PTGS2, SMAD3, SRC 2.05809
[BP] GO:0046683 response to organophosphorus APEX1, APP, PTGS2, TEK, TYR 2.04937
[BP] GO:0030279 None BCL2, CDK6, HIF1A, SMAD3 2.04021
[BP] GO:0008306 None APP, HIF1A, HMGCR, KIT 2.04021
[BP] GO:0003013 None ADORA1, EGFR, HMGCR, PTGS2, SRC, TEK 2.03773
[BP] GO:0033135 regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, PIK3CA, PTGS2 2.03698
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, MMP9, PTGS2, SMAD3, SRC, XDH 2.02789
[BP] GO:1903827 regulation of cellular protein localization APP, BCL2, CSNK2A1, EGFR, GSK3B, PTGS2, PTPN1, SMAD3, SRC, TERT 2.02394
[BP] GO:0060968 None DNMT1, EGFR, ESR1, PHF8, TERT 2.02394
[BP] GO:0070229 negative regulation of lymphocyte apoptotic process AURKB, HIF1A, IDO1 2.02359
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.02359
[BP] GO:0051051 negative regulation of transport ADORA1, APP, BCL2, GPR35, GSK3B, HMGCR, HSPA1A, MMP9, PTGS2 2.02052
[BP] GO:0009411 response to UV AURKB, BCL2, EGFR, PTGS2, TYR 2.01254
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC 2.01141
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.00742
[BP] GO:0043627 response to estrogen CA2, ESR1, GBA, TEK 2.00742
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, IDO1, PTGS2, SRC 2.00742
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.00742
[BP] GO:1990535 None APP, INSR 2.00742
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.00742
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP3A4 2.00742
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GSK3B, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MGAM, MMP12, MMP2, MMP9, NQO2, NUAK1, PHF8, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 5.70454
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, APP, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GSK3B, HIF1A, HMGCR, HSD17B1, HSD17B2, HSPA1A, IDO1, INSR, KDR, KIT, MGAM, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 4.93352
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA9, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GSK3B, HIF1A, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MGAM, MMP12, MMP2, MMP9, NQO2, NUAK1, PHF8, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 4.77438
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, EGFR, ESR1, FLT3, FUT7, GAA, GBA, GLO1, GPR35, GSK3B, HMGCR, HSD17B2, IGF1R, INSR, KDR, KIT, MET, MGAM, MMP2, PHF8, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TYR 3.47612
[CC] GO:0043231 intracellular membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, APEX1, APP, AURKB, BACE1, BCL2, CA4, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP4, FLT3, FUT7, GAA, GLO1, GSK3B, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, KIT, MMP12, MMP2, NUAK1, PHF8, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 3.45999
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, EGFR, ESR1, FLT3, GAA, GLO1, GPR35, GSK3B, IGF1R, INSR, KDR, KIT, MET, MGAM, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SMAD3, SRC, TEK, TERT 2.78002
[CC] GO:0045121 membrane raft APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.6967
[CC] GO:0098857 membrane microdomain APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.68154
[CC] GO:0098589 membrane region APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.24678
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.21542
[CC] GO:0044464 cell part ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GPR35, GSK3B, HIF1A, HMGCR, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MGAM, MMP12, MMP2, MMP9, NQO2, NUAK1, PHF8, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.19696
[CC] GO:0031090 None ALOX5, APP, BACE1, BCL2, CA4, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, EGFR, FUT7, GAA, GBA, HMGCR, INSR, MGAM, PHF8, PTGS1, PTGS2, SMAD3, SRC, TNKS, TNKS2, TYR 2.17815
[CC] GO:0005783 None ADORA1, APEX1, APP, BCL2, CA4, CYP19A1, FLT3, HMGCR, HSPA1A, KDR, PTGS2, PTPN1, XDH 2.16406
[CC] GO:0005829 cytosol AKR1B1, AKR1B10, ALOX5, APP, AURKB, BCL2, CA1, CA2, CA7, CBR1, CDC25B, CDK6, CSNK2A1, DAO, DHFR, DUSP3, FABP3, FABP4, FLT3, GLO1, GSK3B, HIF1A, HSD17B1, HSPA1A, IDO1, NQO2, PIK3CA, PIK3CB, PIM1, PTPN1, SMAD3, SRC, TNKS, TNKS2, TYR, XDH 2.1318
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.00742
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GSK3B, HMGCR, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PHF8, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 21.9435
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DYRK1A, EGFR, ESR1, FABP3, FABP4, FLT3, GLO1, GSK3B, HMGCR, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PHF8, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 14.1304
[MF] GO:0046914 transition metal ion binding ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PHF8, PIM1, PTPN1, RORC, SMAD3, TNKS, TYR, XDH 12.3813
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.0152
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, HMGCR, HSD17B1, HSD17B2, IDO1, NQO2, PHF8, PTGS1, PTGS2, TYR, XDH 9.77943
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 8.63227
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DYRK1A, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A 8.53114
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 7.72226
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 7.17281
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 7.0609
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 6.82147
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, DNMT1, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PHF8, PTPN1, RORC, SMAD3, TNKS 6.61453
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.59794
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AURKB, AXL, CDK6, CSNK2A1, DAO, DHFR, DNMT1, DYRK1A, EGFR, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, XDH 6.48665
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, HMGCR, HSD17B1, IDO1, NQO2, PTGS1, PTGS2, SRC, XDH 6.42716
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 6.30224
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.1695
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, IDO1, PTGS1, PTGS2, SRC 6.13327
[MF] GO:0000166 nucleotide binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DAO, DHFR, DNMT1, DYRK1A, EGFR, FLT3, GSK3B, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, XDH 6.12463
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DAO, DHFR, DNMT1, DYRK1A, EGFR, FLT3, GSK3B, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, XDH 6.12388
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TERT 5.94848
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, ESR1, GLO1, IDO1, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PHF8, PIM1, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 5.92713
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, IDO1, PTGS1, PTGS2, SRC 5.89098
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, ESR1, GLO1, IDO1, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PHF8, PIM1, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 5.70273
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PHF8, PTGS1, PTGS2, TYR 5.49749
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR, KIT 5.24758
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.2367
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.97606
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 4.93121
[MF] GO:0043168 anion binding ABCB1, APP, AURKB, AXL, CDK6, CSNK2A1, DAO, DHFR, DYRK1A, EGFR, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, XDH 4.93047
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB 4.88873
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A 4.75454
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A 4.60727
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A 4.56715
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PHF8, XDH 4.36303
[MF] GO:1901363 heterocyclic compound binding ABCB1, ADORA1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DYRK1A, EGFR, ESR1, FLT3, GSK3B, HIF1A, HMGCR, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 4.30119
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DNMT1, DYRK1A, EGFR, ESR1, FLT3, GSK3B, HIF1A, HMGCR, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 4.21076
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PHF8, PIK3CA, PIM1, PTPN1, SRC, TEK 4.10868
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 3.91068
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, NQO2 3.82534
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HMGCR, HSD17B1, HSD17B2, XDH 3.7854
[MF] GO:0042802 identical protein binding ACHE, APP, BCL2, CSNK2A1, DYRK1A, EGFR, ESR1, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, NQO2, PTGS2, SMAD3, TERT, TOP2A, TYR, XDH 3.58048
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.57011
[MF] GO:0035639 purine ribonucleoside triphosphate binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A 3.44702
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.33138
[MF] GO:0032555 purine ribonucleotide binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A 3.31344
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 3.30265
[MF] GO:0097367 carbohydrate derivative binding ABCB1, ADORA1, APP, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A 3.27678
[MF] GO:0017076 purine nucleotide binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A 3.27586
[MF] GO:0032553 ribonucleotide binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A 3.26613
[MF] GO:0019899 enzyme binding APP, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, CYP3A4, DUSP3, EGFR, ESR1, GSK3B, HIF1A, HMGCR, HSPA1A, KIT, MET, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS2, TOP2A 3.23035
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 3.19315
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 3.1121
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD17B1, HSD17B2 3.09777
[MF] GO:0035004 phosphatidylinositol 3-kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 2.98466
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PTPN1, SMAD3, SRC 2.98233
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, AXL, BCL2, DAO, EGFR, FLT3, HIF1A, HMGCR, KIT, NQO2, PTGS2, SMAD3, TERT, TOP2A, TYR, XDH 2.934
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.934
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PTPN1, SMAD3, SRC 2.76417
[MF] GO:0051213 dioxygenase activity ALOX5, IDO1, PHF8, PTGS1, PTGS2 2.64811
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.54452
[MF] GO:0032450 None GAA, MGAM 2.54452
[MF] GO:0016740 transferase activity AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, EGFR, FLT3, FUT7, GSK3B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TERT, TNKS, TNKS2 2.47922
[MF] GO:0019902 phosphatase binding BCL2, EGFR, HMGCR, MET, PTPN1, SMAD3 2.45589
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HIF1A, HSPA1A, KDR 2.38983
[MF] GO:0019900 None AURKB, CDC25B, DUSP3, EGFR, ESR1, GSK3B, HIF1A, PTPN1, SMAD3, SRC, TOP2A 2.31341
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.31341
[MF] GO:0051425 None APP, INSR 2.31341
[MF] GO:0004558 None GAA, MGAM 2.31341
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.31341
[MF] GO:0042803 protein homodimerization activity ACHE, BCL2, FLT3, HMGCR, KIT, NQO2, PTGS2, SMAD3, TERT, TOP2A, TYR, XDH 2.24972
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CDK6, CSNK2A1, DYRK1A, EGFR, GSK3B, NUAK1, PIK3CA, PIM1 2.24972
[MF] GO:0019903 protein phosphatase binding BCL2, EGFR, HMGCR, MET, PTPN1 2.20084
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.19696
[MF] GO:0019901 None CDC25B, DUSP3, EGFR, ESR1, GSK3B, HIF1A, PTPN1, SMAD3, SRC, TOP2A 2.16045
[MF] GO:0005057 signal transducer activity, downstream of receptor EGFR, INSR, KDR, KIT, SMAD3 2.14431
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.13673
[MF] GO:0043559 insulin binding IGF1R, INSR 2.13673
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX5, IDO1, PTGS2 2.13673
[MF] GO:0008134 transcription factor binding APEX1, BCL2, ESR1, FLT3, GSK3B, HIF1A, PIM1, SMAD3, SRC, TERT 2.10962
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX5, IDO1, PTGS2 2.10054
[MF] GO:0051721 None BCL2, HMGCR, PTPN1 2.05892
[MF] GO:0016798 None APEX1, FUCA1, GAA, GBA, MGAM 2.04937
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.04937
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.02359
[MF] GO:0090599 None GAA, MGAM 2.00742
[MF] GO:0004064 arylesterase activity CA1, CA2 2.00742


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 10.4147
Pathways in cancer_Homo sapiens_hsa05200 GSK3B, SMAD3, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, HIF1A, EGFR, IGF1R, CDK6, PIK3CA, KIT, BCL2, MET 9.5136
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MGAM, DNMT1, GAA, GBA, AKR1B1, HMGCR, PTGS2, TYR, CYP3A4, CYP19A1, PTGS1, DHFR, FUT7, DAO, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, IDO1 8.4562
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.4147
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, HIF1A, EGFR, IGF1R 7.7167
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.7167
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, CDK6, ABCB1, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 7.1948
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 7.1948
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, CDK6, PIK3CA, INSR, KIT, KDR, BCL2, TEK, PIK3CB, MET, EGFR, IGF1R 6.7354
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, EGFR, HSPA1A 6.919
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, INSR, KIT, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 6.7354
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, INSR, BCL2, TEK, PIK3CB, HIF1A, EGFR, IGF1R 6.8236
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 7.1454
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, KIT, PIK3CB, MET, HIF1A, EGFR 6.8219
Focal adhesion_Homo sapiens_hsa04510 GSK3B, PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, EGFR, IGF1R 5.7964
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, INSR, KIT, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 5.3953
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, EGFR, IGF1R 5.3428
Prostate cancer_Homo sapiens_hsa05215 GSK3B, PIK3CA, BCL2, PIK3CB, EGFR, IGF1R 4.8306
Hepatitis B_Homo sapiens_hsa05161 CDK6, SMAD3, PIK3CA, SRC, BCL2, PIK3CB, MMP9 4.7324
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, MMP2, BCL2, PIM1, PIK3CB 4.5696
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 5.0185
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.1927
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, KIT, PIM1, PIK3CB 4.5696
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KIT, KDR, MET, EGFR, IGF1R, HSPA1A 4.2195
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.4458
Glioma_Homo sapiens_hsa05214 CDK6, PIK3CA, PIK3CB, EGFR, IGF1R 4.3757
Colorectal cancer_Homo sapiens_hsa05210 GSK3B, SMAD3, PIK3CA, BCL2, PIK3CB 4.4284
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.3818
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, PIK3CA, SRC, PIK3CB, ESR1, HIF1A 4.2941
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, SMAD3, PIK3CA, PIK3CB, EGFR 4.3581
Measles_Homo sapiens_hsa05162 GSK3B, CDK6, CSNK2A1, PIK3CA, PIK3CB, HSPA1A 4.009
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R 4.0514
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, PIK3CA, SRC, PIK3CB, ESR1 4.2146
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.1985
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, PIK3CA, SRC, PIK3CB, EGFR 3.8884
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 3.901
Insulin resistance_Homo sapiens_hsa04931 PTPN1, GSK3B, PIK3CA, INSR, PIK3CB 3.452
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A 3.3097
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 3.1924
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.2853
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, HMGCR, IGF1R 3.2378
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, SMAD3, PIK3CA, PIK3CB, IGF1R 3.0232
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, GSK3B, PIK3CA, INSR, PIK3CB 3.0516
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, INSR, KIT, PIK3CB, EGFR 3.0055
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2, EGFR 2.8286
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, PIK3CA, PIK3CB, EGFR 3.4605
Endometrial cancer_Homo sapiens_hsa05213 GSK3B, PIK3CA, PIK3CB, EGFR 3.5766
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, INSR, ADORA1, PIK3CB 2.7423
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET, HIF1A 3.2378
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, SMAD3, PIK3CA, PIK3CB 3.1086
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, PTGS2, PTGS1 3.3097
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.6931
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.7464
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB, HIF1A, EGFR 2.6513
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PIK3CB 2.5264
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.5342
Galactose metabolism_Homo sapiens_hsa00052 MGAM, AKR1B10, GAA, AKR1B1 4.3818
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.0232
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, HMGCR, CYP3A4 3.1464
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, PTGS2, PTGS1 2.5187
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.4076
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B, PIK3CA, BCL2, PIK3CB 2.4276
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.4415
Hepatitis C_Homo sapiens_hsa05160 GSK3B, PIK3CA, PIK3CB, EGFR 2.289
Cell cycle_Homo sapiens_hsa04110 GSK3B, CDK6, SMAD3, CDC25B 2.388
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B, PIK3CA, INSR, PIK3CB 2.1251
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1, IDO1 3.9974
HTLV-I infection_Homo sapiens_hsa05166 GSK3B, SMAD3, PIK3CA, TERT, PIK3CB 2.0591
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET, EGFR 2.0155
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 2.0659
Influenza A_Homo sapiens_hsa05164 GSK3B, PIK3CA, PIK3CB, HSPA1A 1.9255
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8983
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2725
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2819
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.2779
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, PIK3CA, SRC, PIK3CB 1.8508
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, PIK3CA, SRC, PIK3CB 1.7469
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB, EGFR 1.6882
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3644
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.4582
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.469
Dopaminergic synapse_Homo sapiens_hsa04728 GSK3B 0.3743
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3874
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B, SMAD3, CSNK2A1 1.4582
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1 0.8505
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.9038
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.4234
Lysosome_Homo sapiens_hsa04142 FUCA1, GAA, GBA 1.6087
cAMP signaling pathway_Homo sapiens_hsa04024 PIK3CA, ADORA1, PIK3CB 1.1316
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.7282
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, GSK3B, APP 1.2989
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6992
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 1.8435
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B, SMAD3 0.7781
Melanogenesis_Homo sapiens_hsa04916 GSK3B, KIT, TYR 1.8242
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8327
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.4525
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.8526
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4686
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.787
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4676
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.8505
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 0.8739
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B, PIK3CA, PIK3CB 1.787
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4814
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B, PIK3CA, PIK3CB 2.1322
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.997
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.8911
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.488
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5021
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4866
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.0374
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.0491
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.0854
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5312
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.1068
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5455
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB, HIF1A 2.3399
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5432
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.1204
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.1204
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2082
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, CYP3A4 2.2549
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1 2.1959
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5637
Peroxisome_Homo sapiens_hsa04146 DAO, XDH 1.1542
Shigellosis_Homo sapiens_hsa05131 SRC 0.5835
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5865
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6082
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.2989
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.2732
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PIK3CB 2.5619
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, CYP3A4 1.2919
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6388
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.6388
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.3273
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 MGAM, PIK3CA, PIK3CB 2.637
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, INSR, PIK3CB 2.7833
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6623
Arginine and proline metabolism_Homo sapiens_hsa00330 DAO 0.6672
Malaria_Homo sapiens_hsa05144 MET 0.6692
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.6672
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4012
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6826
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA 0.6826
Starch and sucrose metabolism_Homo sapiens_hsa00500 MGAM, GAA 1.4351
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6992
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.6936
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 DAO 0.7282
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7752
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7282
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.7752
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.5789
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8505
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.808
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7752
Base excision repair_Homo sapiens_hsa03410 APEX1 0.786
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8526
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8182
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8505
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8435
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.9038
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.765
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0706
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.9144
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 0.9504
Other glycan degradation_Homo sapiens_hsa00511 FUCA1, GBA 2.2549
Folate biosynthesis_Homo sapiens_hsa00790 DHFR, ALPL 2.4327
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2275


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)