TCM Prescription: Ku Bai Zhi Yang Xi Oral Liquid



Prescription Description
Prescription IDTCMF6983
Pinyin NameKu Bai Zhi Yang Xi Ye
Chinese Name苦柏止痒洗液
English NameKu Bai Zhi Yang Xi Oral Liquid
Function Description清热解毒, 除湿止痒。适用于湿热下注所致的阴痒, 带下量多。
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1215 Sophora flavescens 苦参 TCMH1215 ITSAM449-14
TCMH949 Phellodendron amurense 黄柏 TCMH949 ITSAM1586-14
TCMH2134 Smilax glabra 土茯苓 TCMH2134 CPBOL4081-11
TCMH1866 Cnidium monnieri 蛇床子 TCMH1866 ITSAL2575-14
TCMH2494 Artemisia capillaris 茵陈蒿 TCMH2494 ITSAN1371-14
TCMH1127 Lonicera japonica 金银花 TCMH1127 ITSAI3881-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT575 PLA2G2A Phospholipase A2 group IIA Hydrolase P14555
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT904 PGR Progesterone receptor Nuclear receptor P06401
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, KIT, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 16.4322
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TYR, XDH 12.691
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, ALPL, APP, AR, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SRC, TYR 10.7744
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, FABP3, FABP4, FUT7, KIT, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 10.6972
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGS1, PTGS2 10.2391
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGS1, PTGS2 9.94849
[BP] GO:0010033 response to organic substance AKR1B1, AKR1C3, ALPL, APP, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, KIT, MMP2, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SRC, TYR 9.94849
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APP, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FUT7, MIF, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 9.93282
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MIF, MMP1, MMP2, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TYR, XDH 9.85351
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 9.85351
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 9.85351
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AR, CDC25B, CSNK2A1, CYP1B1, DRD2, ESR1, ESRRA, F3, FABP3, FLT3, IGF1R, KDR, KIT, MIF, MMP12, MMP2, MMP9, PGR, PIM1, PTGS1, PTGS2, SRC, XDH 9.69119
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 9.67193
[BP] GO:0014070 response to organic cyclic compound AKR1C3, ALPL, APP, AR, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FLT3, NR3C1, PTGS2, RORC, SRC, TYR 9.56359
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TYR, XDH 9.25707
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 9.15054
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 8.91512
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AKR1C3, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FLT3, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 8.86418
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AKR1C3, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FLT3, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 8.83712
[BP] GO:0033993 response to lipid AKR1C3, ALPL, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, NR3C1, PTGS2, RORC, SRC, TYR 8.68799
[BP] GO:0042221 response to chemical AKR1B1, AKR1C3, ALPL, APP, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SRC, TYR 8.58891
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGS1, PTGS2 8.45459
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TYR, XDH 8.39595
[BP] GO:0009719 response to endogenous stimulus AKR1B1, AKR1C3, ALPL, APP, AR, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, ESRRA, FABP3, FLT3, IGF1R, KIT, MMP2, NR3C1, PPARA, PTGS2, SRC 8.31433
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, XDH 8.30119
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, AKR1C3, ALPL, APP, AR, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, KDR, KIT, MET, MIF, MMP2, MMP9, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SRC, TYR 8.23008
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 8.18679
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, F3, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, KDR, KIT, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SRC, XDH 8.11969
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PIM1, PPARA, RORC, SRC 7.99165
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PPARA, PTGS1, PTGS2 7.93662
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 7.75417
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, KIT, MMP9, PTGS2, SRC 7.71619
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 7.57782
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, APP, AR, AXL, CYP1B1, DRD2, F3, FLT3, KDR, KIT, MET, MIF, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 7.57782
[BP] GO:0009725 response to hormone AKR1B1, AKR1C3, ALPL, AR, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, KIT, NR3C1, PPARA, PTGS2, SRC 7.55906
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AKR1C3, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, XDH 7.52337
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AKR1C3, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 7.39537
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 7.30825
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC 7.14803
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, ALPL, APP, AR, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, NR3C1, PTGS2, RORC, SRC 7.13644
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, XDH 7.09836
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, KIT, PIK3CA, PPARA, SRC, TYR 7.01214
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AKR1C3, ALPL, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SRC 6.83914
[BP] GO:0071310 cellular response to organic substance AKR1B1, AKR1C3, ALPL, APP, AR, AXL, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, NR3C1, PIK3CA, PTGS2, RORC, SRC 6.82848
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, MIF, PIK3CA, PIK3CB, PTGS1, PTGS2 6.75517
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AKR1C3, APP, AR, AXL, CSNK2A1, CYP1B1, DRD2, F3, FLT3, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.6951
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, ESR1, F3, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.66482
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AKR1C3, ALPL, APP, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, KIT, MMP9, PGR, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TYR 6.64606
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AKR1C3, AR, CDC25B, CSNK2A1, DRD2, ESR1, F3, FLT3, IGF1R, KDR, KIT, MIF, MMP12, MMP2, MMP9, PIM1, PTGS2 6.60477
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AKR1C3, APP, AR, AURKB, CDC25B, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, XDH 6.5878
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AKR1C3, APP, AR, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, XDH 6.42126
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AR, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, XDH 6.33617
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 6.32038
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC 6.21402
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, KIT, MET, MIF, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC 6.15698
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALPL, APP, AR, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, KIT, MIF, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TYR 6.13489
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, DRD2, F3, KIT, MET, PIK3CA, PIK3CB, SRC, XDH 6.10979
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AKR1C3, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 6.045
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, AR, CDC25B, DRD1, DRD2, ESRRB, FABP3, FLT3, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.00773
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, AR, CDC25B, DRD1, DRD2, ESRRB, FABP3, FLT3, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.00773
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APP, AR, AXL, CYP1B1, DRD1, ESR1, IGF1R, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SRC 5.94105
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AR, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, XDH 5.939
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, KIT, MET, MIF, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC 5.939
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, APP, AR, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRB, F3, FABP4, HSD17B2, IGF1R, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TYR 5.93344
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AKR1C3, APP, AR, AXL, CSNK2A1, CYP1B1, DRD2, ESRRA, F3, FABP4, FLT3, KDR, KIT, MET, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.89033
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, NQO2, PTGS1, RORC 5.86287
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MIF, MMP9, PTGS2, SRC 5.81775
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.70121
[BP] GO:0032787 None AKR1C3, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PPARA, PTGS1, PTGS2 5.69895
[BP] GO:0015701 bicarbonate transport CA12, CA14, CA2, CA4, CA7, CA9 5.68988
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F3, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.58077
[BP] GO:0051716 cellular response to stimulus AKR1B1, AKR1C3, ALPL, APP, AR, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MIF, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, PTPN1, RORC, SRC 5.51589
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MIF, MMP9, PTGS2, SRC 5.464
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F3, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.46331
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, ESR1, HSD11B1, HSD17B1, HSD17B2 5.4177
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, AR, CDC25B, DRD1, DRD2, ESRRB, FABP4, FLT3, IGF1R, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 5.38895
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AKR1C3, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 5.30033
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD1, DRD2 5.24303
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, AR, CDC25B, DRD2, ESRRB, FLT3, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.18642
[BP] GO:0019371 None AKR1C3, CBR1, PTGS1, PTGS2 5.05968
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, AR, CDC25B, DRD1, DRD2, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 5.04223
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MIF, MMP9, PTGS2, SRC 5.031
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MIF, MMP9, PTGS2, SRC 5.01483
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, AR, CDC25B, DRD1, DRD2, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 4.99184
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, F3, KIT, MET, PIK3CA, PIK3CB, SRC 4.9804
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, ALPL, APP, AR, AXL, CDC25B, CYP19A1, CYP1A1, DRD1, ESR1, ESRRB, HSD17B2, KIT, MMP2, MMP9, PGR, PTGS2, SRC 4.70466
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, AR, CDC25B, DRD2, FLT3, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.69468
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, XDH 4.66117
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, ALPL, AR, AXL, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, KIT, PGR, PTGS2, SRC 4.65906
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 4.63475
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, AR, CDC25B, DRD1, DRD2, FABP4, FLT3, IGF1R, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.6125
[BP] GO:0010038 response to metal ion AKR1C3, APP, CA2, CYP1A1, CYP1A2, DRD2, FABP4, KIT, MMP9, PTGS2 4.5981
[BP] GO:0006730 one-carbon metabolic process CA12, CA2, CA4, CA7, CA9 4.57697
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, AR, DRD2, FLT3, KDR, KIT, MIF, PIK3CB, PTPN1, SRC, XDH 4.53771
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, TYR 4.53372
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, MIF, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC 4.51255
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PIM1, PPARA, PTGS1, PTGS2, TYR 4.49276
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1, DRD2, PTGS2 4.46966
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.35878
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC 4.35878
[BP] GO:0048869 cellular developmental process ACHE, AKR1C3, ALPL, APP, AR, AXL, CBR1, CDC25B, CYP1A1, DRD1, DRD2, ESR1, ESRRB, FABP4, FLT3, FUT7, KDR, KIT, MET, MIF, MMP2, MMP9, PGR, PTGS2, RORC, SRC 4.35546
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, NR3C1, PGR, SRC 4.32616
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CYP1A1, ESR1, FLT3, KIT, MET, MIF, PIK3CB, PIM1, SRC, TYR 4.28367
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 4.22722
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, KIT, PIM1, SRC 4.22447
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 4.19934
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, XDH 4.16639
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, AKR1C3, CYP1A1, FABP3, FLT3, KIT, PPARA, PTGS2, RORC, SRC 4.15011
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AKR1C3, APP, AR, DRD1, ESR1, FLT3, IGF1R, KIT, MMP2, NR3C1, PTGS2, SRC 4.09499
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, ESR1, KIT, PGR, PPARA, RORC, SRC 4.06773
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, DRD1, DRD2, KDR, MIF, PIK3CB, PTGS2, SRC 4.01135
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PIM1, PPARA, PTGS1, PTGS2, TYR 4.00192
[BP] GO:0006082 organic acid metabolic process AKR1C3, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PIM1, PPARA, PTGS1, PTGS2, TYR 3.90856
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, FUT7, KDR, KIT, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 3.90856
[BP] GO:0048545 response to steroid hormone AKR1C3, ALPL, AR, CA2, FLT3, NR3C1, PTGS2, SRC 3.89547
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, DRD1, DRD2, KIT, PTGS2 3.87775
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, DRD1, DRD2, KIT, PTGS2 3.87775
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, AR, DRD2, FLT3, IGF1R, KDR, KIT, MIF, PIK3CB, PTPN1, SRC, XDH 3.87741
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.7303
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.7201
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.7201
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, F3, FABP4, FLT3, IGF1R, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.71336
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, AR, CDC25B, CSNK2A1, DRD2, ESR1, F3, FLT3, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.66829
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, ESR1, ESR2, F3, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.66164
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 3.65795
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DRD2, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 3.63128
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, FUT7, KDR, KIT, MET, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 3.63128
[BP] GO:0006693 None AKR1C3, MIF, PTGS1, PTGS2 3.61648
[BP] GO:0006692 None AKR1C3, MIF, PTGS1, PTGS2 3.61648
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP3A4 3.61049
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, NR3C1, PGR, PPARA, PTGS2, RORC, SRC 3.60697
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, SRC 3.59448
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AKR1C3, APP, AR, AURKB, CSNK2A1, DRD2, ESR1, ESR2, ESRRA, FABP4, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SRC, XDH 3.5797
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.56638
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.56638
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.56638
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F3, FABP4, FLT3, IGF1R, KIT, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, XDH 3.52332
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, ESR1, F3, FABP4, KDR, MET, MIF, MMP12, PPARA, PTGS2 3.51931
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, FUT7, KDR, KIT, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 3.50394
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AR, AXL, CA2, CSNK2A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP2, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTPN1, RORC, SRC 3.4958
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DRD2, FABP4, FLT3, IGF1R, KIT, MIF, PIK3CA, PIK3CB, PTPN1, SRC 3.49016
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APP, AXL, CYP1B1, MMP9, PTGS1, PTGS2, SRC 3.49005
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CYP1A1, DRD1, ESR1, KIT, PGR, PTGS2, SRC 3.49005
[BP] GO:0030335 positive regulation of cell migration APP, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.49005
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, CA12, CA2, CA7, DRD1, DRD2, ESR1, FABP3, FABP4, FLT3, MET, PIK3CA, PIK3CB, SRC 3.48788
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, AR, CDC25B, DRD2, FLT3, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.48788
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, PTGS2 3.48788
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.45183
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, AR, CDC25B, DRD2, ESR1, F3, FLT3, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.44894
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, AKR1C3, CSNK2A1, DRD1, DRD2 3.44637
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIM1, SRC 3.43565
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.43565
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, MET, PIK3CA 3.42915
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 3.42507
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.3972
[BP] GO:2000147 positive regulation of cell motility APP, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.38677
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.35565
[BP] GO:0048608 reproductive structure development AKR1C3, AR, AXL, CYP19A1, ESR1, HSD17B2, KIT, SRC 3.34417
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, AKR1C3, APP, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, XDH 3.34413
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, PTGS2, SRC 3.33974
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.32855
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, AKR1C3, APP, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, XDH 3.3241
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.30762
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP3A4 3.30762
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AR, AURKB, CDC25B, DRD2, ESR1, ESR2, F3, FLT3, KIT, MET, MIF, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, XDH 3.30677
[BP] GO:0051272 positive regulation of cellular component movement APP, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.30054
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.28364
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, AKR1C3, APP, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, XDH 3.25787
[BP] GO:0071383 None AKR1C3, AR, FLT3, NR3C1, SRC 3.23041
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, KDR, NR3C1, PTGS2, SRC 3.23041
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, AR, CDC25B, DRD1, DRD2, FABP4, FLT3, IGF1R, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.22539
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DRD2, FABP4, FLT3, IGF1R, KIT, MIF, PIK3CA, PIK3CB, PTPN1, SRC 3.21831
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, DRD1, DRD2, ESR1, ESR2, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 3.21676
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, DRD1, DRD2, ESR1, ESR2, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 3.20161
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MET, MMP12, NR3C1, PGR, PPARA, PTGS2, RORC, SRC 3.2014
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 3.19674
[BP] GO:0040017 positive regulation of locomotion APP, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.19122
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, DRD1, DRD2, KIT, MMP2, PPARA, PTGS2, SRC, TYR 3.15096
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, DRD2, ESR1, F3, FABP4, IGF1R, MET, MIF, MMP12, MMP2, PPARA, PTGS2, PTPN1, SRC, XDH 3.14835
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC 3.14149
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, DRD1, DRD2, FABP3, KDR, NR3C1, PTGS2, SRC 3.13956
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, KDR, SRC 3.13904
[BP] GO:0046456 icosanoid biosynthetic process ALOX5, MIF, PTGS1, PTGS2 3.12016
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DRD2, FABP4, FLT3, IGF1R, KIT, MIF, PIK3CA, PIK3CB, PTPN1, SRC 3.10561
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 3.09398
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, KIT, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SRC 3.07409
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, AR, CYP19A1, DRD1, DRD2, ESR1, ESR2, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 3.07378
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CYP1A1, CYP1B1, DRD1, DRD2, KDR, SRC 3.04121
[BP] GO:0046486 glycerolipid metabolic process ACHE, CSNK2A1, DRD2, FABP3, FABP4, KIT, MET, PIK3CA, PIK3CB 3.02582
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, FLT3, KIT, MIF, PIK3CA, PIK3CB, PTPN1, SRC 3.02269
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DRD1, DRD2, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 3.01411
[BP] GO:1902532 negative regulation of intracellular signal transduction DRD2, ESR1, IGF1R, MET, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 3.00437
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.00124
[BP] GO:0001516 None MIF, PTGS1, PTGS2 3.00124
[BP] GO:0046457 None MIF, PTGS1, PTGS2 3.00124
[BP] GO:0016488 None AKR1B10, AKR1C3 2.98964
[BP] GO:0016487 None AKR1B10, AKR1C3 2.98964
[BP] GO:0016107 None AKR1B10, AKR1C3 2.98964
[BP] GO:0009115 None AOX1, XDH 2.98964
[BP] GO:0006714 None AKR1B10, AKR1C3 2.98964
[BP] GO:0044259 multicellular organismal macromolecule metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.98268
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TYR, XDH 2.97975
[BP] GO:0071248 cellular response to metal ion AKR1C3, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.97469
[BP] GO:0008217 None ADORA1, AR, DRD2, PPARA, PTGS1, PTGS2 2.95972
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, PIK3CB, PTGS2 2.95454
[BP] GO:0015711 organic anion transport CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA 2.9448
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD1, DRD2, ESR1, F3, FLT3, FUT7, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC, TYR, XDH 2.94158
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, CA2, CYP1B1, DRD2, ESRRB, F3, KDR, KIT, MET, MIF, MMP12, MMP9, PIM1, PTGS2, SRC 2.93659
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.93193
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.91696
[BP] GO:0050730 None ADORA1, APP, FLT3, KIT, MIF, PTPN1, SRC 2.90799
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.90759
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CYP1B1, DRD1, DRD2, FUT7, KDR, KIT, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC 2.89964
[BP] GO:0048167 None ADORA1, APP, DRD1, DRD2, KIT, PTGS2 2.89964
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MET, MMP12, NR3C1, PGR, PPARA, PTPN1, RORC, SRC 2.8925
[BP] GO:0031960 response to corticosteroid AKR1C3, ALPL, FLT3, NR3C1, PTGS2, SRC 2.88689
[BP] GO:0031324 negative regulation of cellular metabolic process AKR1C3, APP, AR, AURKB, CSNK2A1, DRD2, ESR1, ESR2, ESRRA, FABP4, IGF1R, MET, MIF, MMP12, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SRC, XDH 2.88334
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, APP, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, XDH 2.85919
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, FLT3, KIT, MIF, PIK3CA, PIK3CB, PTPN1, SRC 2.84344
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, AXL, KIT, MIF, PIK3CA, PIK3CB, PTGS1, PTGS2 2.83534
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, CA12, CA2, CA7, DRD1, DRD2, ESR1, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.82885
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway MIF, MMP9, PTGS2, PTPN1, SRC 2.81141
[BP] GO:0044283 None AKR1B1, AKR1C3, ALOX5, CYP19A1, CYP1A1, CYP3A4, MIF, PTGS1, PTGS2 2.80868
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.79079
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.77575
[BP] GO:0032225 None DRD1, DRD2, PTGS2 2.77575
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, FLT3, KIT, MIF, PIK3CA, PIK3CB, PTPN1, SRC 2.7704
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, IGF1R, KIT, MIF, PIK3CB, PTPN1, SRC 2.76317
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DRD1, DRD2, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 2.75647
[BP] GO:0008542 None APP, DRD1, DRD2, KIT 2.75647
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, APP, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, XDH 2.67882
[BP] GO:0050900 leukocyte migration FUT7, KIT, MIF, MMP1, MMP9, PIK3CA, PIK3CB, SRC 2.67054
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.65936
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, KIT, MIF, PTPN1, SRC 2.6482
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, SRC 2.63581
[BP] GO:0071396 cellular response to lipid AKR1C3, AR, AXL, ESR1, FLT3, NR3C1, RORC, SRC 2.63581
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3 2.63405
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SRC 2.63387
[BP] GO:0044236 multicellular organism metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.61017
[BP] GO:0007632 None APP, DRD1, DRD2, KIT 2.60253
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, NR3C1, SRC 2.59687
[BP] GO:0060748 None AR, PGR 2.59687
[BP] GO:0046110 None AOX1, XDH 2.59687
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.59687
[BP] GO:0016095 None AKR1B10, AKR1C3 2.59687
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, FLT3, KIT, MIF, PIK3CB, PTPN1, SRC 2.59687
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SRC 2.56709
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, DRD2, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SRC 2.56544
[BP] GO:0046686 response to cadmium ion AKR1C3, CYP1A2, KIT, MMP9 2.52566
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.44953
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, PTGS2 2.43919
[BP] GO:0002682 regulation of immune system process ADORA1, APP, AXL, CA2, CYP19A1, DRD2, ESR1, ESRRA, KIT, MIF, MMP12, MMP2, PIK3CA, PIK3CB, PTPN1, SRC 2.43806
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AKR1C3, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, PIK3CB, SRC, XDH 2.41225
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, SRC 2.40464
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, ESR2, KIT, PIM1 2.40464
[BP] GO:0009416 response to light stimulus APP, AURKB, DRD1, DRD2, KIT, PTGS2, TYR 2.40176
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.39661
[BP] GO:1901360 None ACHE, AKR1B1, AKR1B10, AKR1C3, AOX1, APP, AR, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, HSD11B1, HSD17B1, HSD17B2, NR3C1, NR3C2, PGR, PPARA, PTGS2, RORC, TYR, XDH 2.39654
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AKR1C3, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, XDH 2.36133
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SRC 2.35164
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.34377
[BP] GO:0006145 None AOX1, XDH 2.32923
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.32923
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.32923
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.315
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AR, AXL, CA2, CYP1B1, DRD2, ESR1, ESRRA, ESRRB, F3, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PTGS2, SRC, XDH 2.30048
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.30048
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.30009
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC 2.29739
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, ESR1, FABP4, MMP12, MMP2, PPARA, PTGS2, PTPN1, SRC 2.29368
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SRC, XDH 2.28832
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, CDC25B, DRD2, ESR1, F3, FLT3, KIT, MIF, PIK3CA, PIK3CB, PTPN1, SRC, XDH 2.25578
[BP] GO:0048169 None APP, DRD2, KIT 2.25578
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, MIF, MMP9, PTGS2, PTPN1, SRC 2.23862
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.22481
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.21731
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1 2.21678
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CSNK2A1, DRD2, F3, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 2.21611
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.21387
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALPL, AOX1, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, FUT7, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TYR, XDH 2.20893
[BP] GO:0007416 None ACHE, APP, DRD1, DRD2 2.19859
[BP] GO:0001775 cell activation ALOX5, APP, AXL, FLT3, FUT7, KIT, MIF, MMP9, PIK3CA, PIK3CB, RORC, SRC 2.19424
[BP] GO:0006820 anion transport CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA 2.18639
[BP] GO:0032147 activation of protein kinase activity ADORA1, DRD2, KIT, PIK3CA, PIK3CB, PTPN1, SRC 2.18639
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, CA2, CYP19A1, DRD1, DRD2, MIF, MMP12, PTGS2, SRC 2.18123
[BP] GO:0008306 None APP, DRD1, DRD2, KIT 2.18123
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, APP, AR, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, F3, FABP4, FLT3, IGF1R, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.18123
[BP] GO:0007612 None APP, DRD1, DRD2, KIT, PTGS2 2.17709
[BP] GO:0030100 regulation of endocytosis APP, AXL, DRD2, PIK3CB, PTPN1, SRC 2.17096
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.16184
[BP] GO:0021853 None DRD1, DRD2 2.15819
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1 2.15819
[BP] GO:0010641 None F3, SRC 2.15819
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.15819
[BP] GO:1904936 None DRD1, DRD2 2.15819
[BP] GO:0042321 None ADORA1, DRD2 2.15819
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.15039
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.1422
[BP] GO:0010628 positive regulation of gene expression APP, AR, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, KIT, MET, MMP12, NR3C1, PGR, PIK3CB, PPARA, RORC, SRC 2.11846
[BP] GO:0006636 unsaturated fatty acid biosynthetic process MIF, PTGS1, PTGS2 2.10051
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.10051
[BP] GO:0022602 ovulation cycle process ESR1, KIT, PGR, SRC 2.0905
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2 2.0905
[BP] GO:0010631 epithelial cell migration CYP1B1, KDR, KIT, PIK3CA 2.07076
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.07076
[BP] GO:0035265 organ growth AR, CYP19A1, ESR1 2.06386
[BP] GO:1901661 None AKR1B1, AKR1B10, AKR1C3 2.06386
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC 2.06386
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, CA2, CA7, CYP19A1, DRD1, DRD2, MIF, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC 2.05827
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, TYR 2.05472
[BP] GO:0006650 glycerophospholipid metabolic process ACHE, CSNK2A1, DRD2, KIT, MET, PIK3CA, PIK3CB 2.04197
[BP] GO:0050793 regulation of developmental process APP, AR, AXL, CA2, CYP1B1, DRD2, ESR1, ESRRA, ESRRB, F3, KDR, KIT, MIF, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, XDH 2.04197
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.03778
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.03778
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, PTGS2, SRC, XDH 2.03307
[BP] GO:0071276 cellular response to cadmium ion AKR1C3, CYP1A2, MMP9 2.03307
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling IGF1R, PIK3CA, PIK3CB 2.03307
[BP] GO:0001659 None ADORA1, DRD1, DRD2 2.03307
[BP] GO:0051130 positive regulation of cellular component organization APP, AR, AURKB, AXL, DRD2, ESR1, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC 2.0267
[BP] GO:0070542 None AKR1C3, FABP3, PTGS2, SRC 2.0267
[BP] GO:1901570 None ALOX5, MIF, PTGS1, PTGS2 2.0267
[BP] GO:0010760 negative regulation of macrophage chemotaxis CYP19A1, MIF 2.0267
[BP] GO:0021843 None DRD1, DRD2 2.0267
[BP] GO:0046113 None AOX1, XDH 2.0267
[BP] GO:0021830 None DRD1, DRD2 2.0267
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.0267
[BP] GO:0021826 None DRD1, DRD2 2.0267
[BP] GO:0016115 None AKR1B10, AKR1C3 2.0267
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP3A4 2.0267
[BP] GO:1901655 None AKR1B1, AR, NR3C1, SRC 2.01972
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.01972
[BP] GO:0032870 cellular response to hormone stimulus AKR1C3, AR, ESR1, FLT3, KIT, NR3C1, SRC 2.01446
[BP] GO:0009058 None ACHE, AKR1B1, AKR1C3, ALOX5, AR, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B1, HSD17B1, HSD17B2, MIF, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, RORC, TYR 2.0073
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, MIF, PIK3CB 2.00544
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, MIF 2.00544
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, PTGS2, TYR 2.00544
[BP] GO:0009968 negative regulation of signal transduction AR, DRD2, ESR1, ESR2, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 2.00228
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APP, AR, AURKB, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, KDR, KIT, MIF, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TYR, XDH 3.62661
[CC] GO:0044432 endoplasmic reticulum part APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, FLT3, HSD11B1, HSD17B2, NR3C2, PTGS1, PTGS2, PTPN1 3.1967
[CC] GO:0005789 endoplasmic reticulum membrane CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, HSD11B1, HSD17B2, NR3C2, PTGS1, PTGS2 2.93251
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, F3, FLT3, FUT7, HSD11B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP2, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TYR 2.65936
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALPL, AOX1, APP, AR, AURKB, AXL, CA2, CA4, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, IGF1R, KDR, KIT, MIF, MMP12, MMP2, MMP9, NQO2, NR3C1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TYR, XDH 2.15858
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.0267
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, AR, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, TYR, XDH 20.2036
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TYR, XDH 13.7528
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC 10.6972
[MF] GO:0005496 steroid binding AR, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, NR3C1, NR3C2, PGR, RORC 10.6972
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, F3, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TYR, XDH 10.2586
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 10.2577
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APP, AR, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, TYR, XDH 9.85351
[MF] GO:0008270 zinc ion binding AR, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PPARA, PTPN1, RORC 9.66976
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 8.68799
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PTGS1, PTGS2, TYR 8.45459
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PGR, PPARA, RORC 8.45459
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PGR, PPARA, RORC 8.45459
[MF] GO:0004089 carbonate dehydratase activity CA12, CA14, CA2, CA4, CA7, CA9 8.38826
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APP, AR, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, TYR, XDH 8.24942
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PTGS1, PTGS2, SRC 7.99165
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR 7.74697
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PTGS1, PTGS2, SRC 7.71179
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 7.28487
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH 7.14803
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 6.55183
[MF] GO:0008289 lipid binding AR, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD17B1, NR3C1, NR3C2, PGR, PPARA, RORC 6.5471
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, AOX1, CBR1, HSD11B1, HSD17B1, HSD17B2, XDH 6.52589
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, RORC 6.00012
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, DRD1, DRD2, FLT3, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC 5.74834
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 5.63351
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, RORC 5.17385
[MF] GO:0016836 hydro-lyase activity CA12, CA14, CA2, CA4, CA7, CA9 5.14151
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, RORC 4.96834
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.85489
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 4.68482
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, RORC 4.52458
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, CBR1, HSD11B1, HSD17B1, HSD17B2 4.51255
[MF] GO:0016835 carbon-oxygen lyase activity CA12, CA14, CA2, CA4, CA7, CA9 4.41528
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.29624
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, AOX1, XDH 4.18609
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NQO2, NR3C1 4.13127
[MF] GO:0097159 organic cyclic compound binding ADORA1, AOX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, IGF1R, KDR, KIT, MET, MMP12, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, XDH 3.86987
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, CSNK2A1, DRD2, ESR1, ESR2, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP9, NQO2, PGR, PTGS2, TYR, XDH 3.64836
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.59448
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C3, HSD11B1, HSD17B1, HSD17B2 3.56638
[MF] GO:0016229 steroid dehydrogenase activity AKR1C3, HSD11B1, HSD17B1, HSD17B2 3.46999
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.45542
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.43565
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 3.19674
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, IGF1R, KDR, KIT, MET, MMP12, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, XDH 3.14293
[MF] GO:0019899 enzyme binding APP, AR, AURKB, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP3A4, ESR1, ESR2, ESRRB, F3, KIT, MET, MIF, NR3C1, PGR, PPARA, PTGS2, PTPN1, SRC 3.07409
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.98964
[MF] GO:0045550 None AKR1B10, AKR1C3 2.98964
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.98964
[MF] GO:0008389 None CYP2A13, CYP2A6 2.98964
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIM1, SRC 2.93193
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC 2.92262
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.6482
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC 2.59687
[MF] GO:0047718 None AKR1B10, AKR1C3 2.59687
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.59687
[MF] GO:0016829 lyase activity CA12, CA14, CA2, CA4, CA7, CA9 2.52566
[MF] GO:0000978 None AR, ESR1, ESR2, ESRRA, NR3C1, PGR, PPARA, RORC 2.36342
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.32923
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.32923
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.32923
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity KIT, MET, PIK3CA, PIK3CB 2.28095
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.26821
[MF] GO:0000987 None AR, ESR1, ESR2, ESRRA, NR3C1, PGR, PPARA, RORC 2.25578
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity KIT, MET, PIK3CA, PIK3CB 2.21678
[MF] GO:0004033 None AKR1B1, AKR1B10, AKR1C3 2.21387
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.15819
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.15819
[MF] GO:0035004 phosphatidylinositol 3-kinase activity KIT, MET, PIK3CA, PIK3CB 2.12973
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.03307
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC 2.02846
[MF] GO:0043546 None AOX1, XDH 2.0267
[MF] GO:0047035 testosterone dehydrogenase (NAD+) activity AKR1C3, HSD17B2 2.0267
[MF] GO:0051879 Hsp90 protein binding CSNK2A1, KDR, NR3C1 2.0119


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, AKR1C3, CYP1B1, PTGS2, CYP19A1, IGF1R 10.9751
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AKR1C3, CYP1B1, CYP3A4, CYP19A1 10.6568
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 9.4206
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 8.442
Metabolic pathways_Homo sapiens_hsa01100 CBR1, AKR1C3, AKR1B1, PTGS2, TYR, CYP3A4, CYP19A1, PTGS1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 7.2655
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 6.2636
Pathways in cancer_Homo sapiens_hsa05200 AR, PIK3CA, FLT3, MMP1, MMP2, KIT, PIK3CB, PTGS2, MMP9, MET, IGF1R 5.9183
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA2, CA4, CA7, CA9, CA14 9.2811
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, ESR2 6.1612
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 6.2075
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, KIT, KDR, PIK3CB, DRD2, MET, IGF1R 5.178
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, KIT, PIM1, PIK3CB 4.8011
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.6851
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, AKR1C3, PTGS2, PTGS1 4.6796
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.4352
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, KIT, PIK3CB, MET 4.5658
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 4.605
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.3997
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, PIM1, PIK3CB, F3 3.8213
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PGR, PIK3CB, CDC25B, IGF1R 3.8655
cAMP signaling pathway_Homo sapiens_hsa04024 PIK3CA, ADORA1, PIK3CB, DRD1, DRD2, PPARA 3.4557
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R 3.4449
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 3.4449
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KIT, KDR, PIK3CB, MET, IGF1R 3.2372
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.1285
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.1062
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, IGF1R 3.2971
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1, CYP3A4 3.3304
Prostate cancer_Homo sapiens_hsa05215 AR, PIK3CA, PIK3CB, IGF1R 2.9727
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.167
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3304
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA 2.6739
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.6714
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, KIT, KDR, PIK3CB, MET, IGF1R 2.4526
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, PTGS2, PTGS1 2.6535
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.5574
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.5904
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.5904
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, ADORA1, PIK3CB 2.5738
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.2544
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB, IGF1R 2.3423
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, SRC, PIK3CB, MMP9 2.3259
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, PIM1, AOX1, PIK3CB 2.2267
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 2.2267
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, DRD1, NR3C1, DRD2 2.156
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PIK3CB 2.156
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.3423
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, IGF1R 2.3411
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.0703
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.3312
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 2.0703
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 1.9559
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 1.9923
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, PIK3CB 1.833
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, PIK3CB, NR3C2 2.8623
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, PIK3CB, PTGS2 2.0707
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, PIK3CB, IGF1R 1.9097
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.6739
Gap junction_Homo sapiens_hsa04540 SRC, DRD1, DRD2 2.0655
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.73
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, PIK3CB 1.7731
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.7268
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.6625
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.616
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB 1.6423
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.6625
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.6286
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF, TYR 2.9767
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, KIT, PIK3CB 1.6043
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.5602
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2386
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, PIK3CB 1.3009
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.2893
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3379
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3307
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB 1.2501
Calcium signaling pathway_Homo sapiens_hsa04020 DRD1 0.3365
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3371
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.3813
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.35
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.403
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4439
Axon guidance_Homo sapiens_hsa04360 MET 0.4385
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, PIK3CB 0.6094
Apoptosis_Homo sapiens_hsa04210 PIK3CA, PIK3CB 0.9702
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.9634
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.8239
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9718
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.8365
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5146
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.9897
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, PIK3CB 0.9439
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 1.0029
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.5146
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.528
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2 1.0164
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5272
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PIK3CB 1.0673
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.2324
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 1.1798
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.545
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.224
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.1798
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.1761
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.1548
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5473
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.1656
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.1872
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.2324
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.1656
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5461
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.2501
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 1.224
Peroxisome_Homo sapiens_hsa04146 XDH 0.5661
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5817
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.3813
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.4148
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.3813
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6055
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6035
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6153
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.3894
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.429
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.3894
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.6289
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.4915
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.4148
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6375
Shigellosis_Homo sapiens_hsa05131 SRC 0.6375
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6375
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6588
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, PIK3CB 1.4698
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.5376
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.5
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.588
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.6625
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.6286
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.6205
Malaria_Homo sapiens_hsa05144 MET 0.7357
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7455
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.7404
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9462
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.961
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8182
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9048
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.2977
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.9045
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1151
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.9248
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9594
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.9144
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9473
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 1.107
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1731
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.4395


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)