TCM Prescription: Kou Yan Granules



Prescription Description
Prescription IDTCMF6982
Pinyin NameKou Yan Ke Li
Chinese Name口炎颗粒
English NameKou Yan Granules
Function Description清热解毒。用于胃火上炎所致的口舌生疮, 牙龈肿痛。
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1931 Gypsum fibrosum 石膏 TCMH1931
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH2343 Scrophularia ningpoensis 玄参 TCMH2343 ITSAO4295-14
TCMH1681 Artemisia carvifolia 青蒿 TCMH1681 KU555619
TCMH287 Clematidis armandii caulis 川木通 TCMH287
TCMH420 Lophatherum gracile 淡竹叶 TCMH420 GBVY2724-14, GBVT2442-13
TCMH127 Isatis indigotica 板蓝根 TCMH127 KJ765825
TCMH547 Catechu 儿茶 TCMH547
TCMH1363 Arundo donax 芦竹根 TCMH1363 ITSAN4867-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT377 INSR Insulin receptor Kinase P06213
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1241 Human rhinovirus 14
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1271 Shigella flexneri
TCMT1283 Human enterovirus 71
TCMT1284 Penicillium expansum
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1333 Human rhinovirus 1A
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, BCL2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, ESRRA, FABP3, GSK3B, HSD11B2, HSD17B2, IDO1, IGF1R, INSR, MAOB, MMP2, MMP9, PPARA, PTGS2, SRC, TEK, TYR 10.9776
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, ESRRA, FABP3, FABP4, GSK3B, HSD11B2, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MAOB, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TYR 10.0473
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, GPR35, GSK3B, HCAR2, HSPA1A, INSR, KDR, MET, MMP9, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 9.80054
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, DHFR, EGFR, ESR1, F10, F3, FABP3, FABP4, GPR35, GSK3B, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MAOB, MET, PPARA, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 9.80054
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, GPR35, GSK3B, HCAR2, HSPA1A, INSR, KDR, MET, MMP9, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 9.80054
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FUT7, GBA2, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NUAK1, PDE5A, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 9.6815
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, EGFR, ESR1, ESRRA, F3, FABP3, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PDE5A, PTGS2, SMAD3, SRC, TEK, XDH 9.10075
[BP] GO:0042221 response to chemical AKR1B1, ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, ESRRA, FABP3, FABP4, GSK3B, HSD11B2, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MAOB, MMP2, MMP9, PPARA, PTGS2, SMAD3, SRC, TEK, TYR 8.857
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, GPR35, GSK3B, HCAR2, HSPA1A, IDO1, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, PDE5A, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.857
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, GPR35, GSK3B, HCAR2, HSPA1A, IDO1, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, PDE5A, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.4935
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA, PTGS2 8.48
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, GSK3B, HSD11B2, IGF1R, INSR, MAOB, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 8.35779
[BP] GO:0033993 response to lipid ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IDO1, MAOB, PTGS2, SRC, TYR 7.81992
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.51448
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, HSD11B2, INSR, MAOB, PPARA, PTGS2, SRC, TEK 7.50943
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, BCL2, CSNK2A1, CYP1B1, EGFR, F10, F3, GPR35, GSK3B, HSPA1A, INSR, KDR, MET, MMP9, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.50943
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, BCL2, CSNK2A1, CYP1B1, EGFR, ESRRA, F10, F3, FABP4, GPR35, GSK3B, HSPA1A, IDO1, INSR, KDR, MET, MMP2, MMP9, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.34603
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, MAOB, PTGS2, TYR, XDH 7.34603
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FUT7, GBA2, GSK3B, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, NUAK1, PDE5A, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 7.25524
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, GPR35, GSK3B, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.07112
[BP] GO:0080134 regulation of response to stress ADORA1, CDK6, CYP19A1, DHFR, DUSP3, EGFR, ESR1, F3, FABP4, GSK3B, HSPA1A, IDO1, IGF1R, MET, MMP2, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.07112
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 7.07112
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, ESRRA, HSD11B2, MAOB, PTGS2, SRC, TEK, TYR 6.98351
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, GPR35, GSK3B, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.95989
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, F3, FABP4, GPR35, GSK3B, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PDE5A, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.95989
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FUT7, GBA2, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PDE5A, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 6.80229
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FUT7, GBA2, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NUAK1, PDE5A, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 6.71374
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.67164
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 6.64877
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 6.62839
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FUT7, GBA2, HSPA1A, IDO1, PDE5A, PPARA, PTGS2, TYR, XDH 6.62839
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 6.62839
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.54936
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, DHFR, DUSP3, EGFR, ESR1, F10, F3, FUT7, GBA2, GSK3B, HSPA1A, IDO1, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NUAK1, PDE5A, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 6.39828
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, GPR35, GSK3B, HCAR2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 6.39828
[BP] GO:0048513 animal organ development ACHE, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, HSD11B1, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 6.39828
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESRRA, ESRRB, GBA2, GSK3B, HSD11B1, HSD17B2, INSR, KDR, MAOB, MMP9, PPARA, PTGS2, SMAD3, SRC, TEK, TYR 6.39828
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, GSK3B, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.29708
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, BCL2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, F10, F3, FABP4, HSD11B2, HSD17B2, IDO1, IGF1R, INSR, MET, MMP1, MMP2, MMP9, PDE5A, PPARA, PTGS2, SMAD3, SRC, TEK, TNKS2, TYR 6.29546
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, BCL2, CSNK2A1, EGFR, GSK3B, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 6.27771
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PDE5A, PTGS2, PTPN1, SRC, TEK, XDH 6.21859
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, GSK3B, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.16257
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, BCL2, CYP1B1, EGFR, F10, F3, GPR35, HSPA1A, INSR, KDR, MET, PDE5A, PTGS2, PTPN1, SRC, TEK, XDH 6.12728
[BP] GO:0030335 positive regulation of cell migration BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 6.09692
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, DHFR 6.08797
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, BCL2, CSNK2A1, EGFR, GSK3B, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK 6.04485
[BP] GO:2000147 positive regulation of cell motility BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.93657
[BP] GO:0010035 response to inorganic substance AKR1B1, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MAOB, MMP9, PTGS2, SRC 5.89943
[BP] GO:0051272 positive regulation of cellular component movement BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.80694
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, BCL2, CA2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FUT7, GBA2, GSK3B, HSD11B1, HSD17B2, INSR, KDR, MAOB, MET, MMP2, MMP9, PPARA, PTGS2, SMAD3, SRC, TEK, TNKS2, TYR 5.76565
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, GSK3B, HSPA1A, IDO1, IGF1R, KDR, MAOB, MET, MMP9, PDE5A, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.71948
[BP] GO:0040017 positive regulation of locomotion BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.65368
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.6169
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, GSK3B, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.56506
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, GSK3B, HSPA1A, IDO1, MAOB, MMP1, MMP2, MMP9, PDE5A, SRC, XDH 5.52029
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.47159
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 5.36564
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, BCL2, CSNK2A1, EGFR, GSK3B, HSPA1A, IDO1, IGF1R, KDR, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK 5.36218
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 5.26001
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, GSK3B, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MAOB, MET, MMP9, PDE5A, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.1167
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, BCL2, CDC25B, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, F3, FABP4, GSK3B, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 5.08266
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, ESRRA, F10, F3, FABP3, FABP4, GSK3B, HSD11B2, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MAOB, MMP2, MMP9, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TYR 5.07467
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, BCL2, CDC25B, CDK6, CSNK2A1, DHFR, DUSP3, EGFR, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE5A, PTGS2, PTPN1, SRC, TEK, TNKS, XDH 5.04269
[BP] GO:0009893 positive regulation of metabolic process ADORA1, BCL2, CDC25B, CSNK2A1, DHFR, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP9, PDE5A, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.04269
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, GPR35, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.04269
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, GSK3B, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PTGS2, SMAD3, SRC 4.99071
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CDK6, CYP19A1, DUSP3, EGFR, ESR1, ESR2, GSK3B, HSPA1A, IGF1R, MET, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.99071
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 4.96714
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP9, PDE5A, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.91766
[BP] GO:0032844 regulation of homeostatic process ADORA1, BCL2, CA2, CA7, CDK6, EGFR, HCAR2, KDR, PTGS2, SRC, TNKS, TNKS2 4.91766
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, GSK3B, KDR, SMAD3, SRC, TEK 4.8813
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, BCL2, CDC25B, CSNK2A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, GPR35, GSK3B, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PDE5A, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 4.87933
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.87584
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.76486
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, BCL2, CDC25B, CDK6, CSNK2A1, DHFR, DUSP3, EGFR, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE5A, PTGS2, PTPN1, SRC, TEK, TNKS, XDH 4.7433
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, DHFR, EGFR, INSR, PTGS2, SMAD3, XDH 4.67288
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, IGF1R, INSR, KDR, MMP9, NUAK1, PDE5A, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.64266
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, BCL2, CDC25B, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP9, PDE5A, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.6146
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, IGF1R, INSR, KDR, MMP9, NUAK1, PDE5A, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.59296
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DUSP3, EGFR, ESR1, ESR2, GPR35, GSK3B, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH 4.5675
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, BCL2, CA2, CDK6, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, GSK3B, HCAR2, HSPA1A, IDO1, INSR, KDR, MET, MMP9, PDE5A, PTGS2, SMAD3, SRC, TEK, TNKS2, XDH 4.5673
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DUSP3, EGFR, ESR1, ESR2, GPR35, GSK3B, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH 4.55667
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, DHFR, EGFR, PPARA, SMAD3 4.51385
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, HSPA1A, IDO1, MAOB 4.50306
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.50306
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, ESR1, F3, IGF1R, INSR, KDR, MMP2, MMP9, PTGS2, TEK 4.48308
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DHFR, EGFR, FABP3, GSK3B, HSD11B2, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR 4.47626
[BP] GO:1901652 response to peptide AKR1B1, FABP3, GSK3B, HSD11B2, IGF1R, INSR, PPARA, PTGS2, SRC, TEK 4.34888
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, IDO1, MMP2, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 4.31355
[BP] GO:0030155 regulation of cell adhesion BCL2, CDK6, CYP1B1, DUSP3, GSK3B, IDO1, KDR, NUAK1, PDE5A, PPARA, SMAD3, SRC, TEK 4.30077
[BP] GO:0046777 protein autophosphorylation CSNK2A1, EGFR, GSK3B, IGF1R, INSR, KDR, SRC, TEK 4.26385
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, BCL2, CDK6, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, GSK3B, IGF1R, INSR, KDR, MMP2, PTGS2, SMAD3, SRC 4.22348
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, GSK3B, KDR, SMAD3, TEK 4.12471
[BP] GO:1901698 response to nitrogen compound AKR1B1, DHFR, EGFR, FABP3, GSK3B, HSD11B2, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR 4.12029
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, EGFR, ESRRB, FABP3, INSR, KDR, MMP9, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.0848
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, EGFR, ESRRB, FABP3, INSR, KDR, MMP9, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.0848
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, GBA2, MET, PPARA, PTGS2 4.07211
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PDE5A, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.06191
[BP] GO:0051896 regulation of protein kinase B signaling EGFR, F10, F3, INSR, MET, SRC, TEK, XDH 4.05913
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.05886
[BP] GO:0044093 positive regulation of molecular function ADORA1, BCL2, CDC25B, DHFR, EGFR, ESR1, ESR2, F3, GSK3B, HSPA1A, INSR, MET, MMP9, PDE5A, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 4.0481
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, IDO1, PPARA, PTGS2, SMAD3, TEK 3.99782
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, HSD11B2, MAOB, PTGS2, SRC 3.96212
[BP] GO:0051897 positive regulation of protein kinase B signaling EGFR, F10, F3, INSR, MET, SRC, TEK 3.91405
[BP] GO:0042493 response to drug AKR1B1, BCL2, CDK6, CYP1A1, CYP1B1, DHFR, EGFR, FABP3, HSD11B2, KDR, MAOB, PTGS2, SRC 3.90929
[BP] GO:0010638 positive regulation of organelle organization BCL2, GSK3B, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 3.90929
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 3.90929
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, F3, GSK3B, HSPA1A, INSR, KDR, MMP9, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.90827
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, BCL2, CA2, CYP1A1, EGFR, HSD11B2, HSPA1A, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TYR 3.90827
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, HSD11B2, MAOB, PTGS2, SRC 3.87733
[BP] GO:0044092 negative regulation of molecular function ADORA3, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, GSK3B, IGF1R, MET, MMP9, PPARA, PTGS2, PTPN1, SRC, TNKS 3.81835
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 3.81433
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, DHFR, GBA2, MAOB, TYR 3.79673
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MAOB, MMP9, PTGS2 3.79006
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, MAOB, XDH 3.77108
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, MAOB 3.76679
[BP] GO:0001101 response to acid chemical AKR1B1, DHFR, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 3.76679
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.76679
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 3.76679
[BP] GO:0042325 regulation of phosphorylation ADORA1, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP4, IGF1R, INSR, KDR, MMP9, PDE5A, PPARA, PTGS2, PTPN1, SRC, TEK, XDH 3.74442
[BP] GO:0080135 regulation of cellular response to stress CDK6, DHFR, DUSP3, EGFR, GSK3B, HSPA1A, IGF1R, MET, NUAK1, PTGS2, PTPN1, XDH 3.71679
[BP] GO:0022414 reproductive process AKR1B1, ALPL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, IDO1, INSR, MMP2, MMP9, PTGS2, SRC 3.69295
[BP] GO:0009894 regulation of catabolic process ADORA1, BCL2, CSNK2A1, EGFR, ESRRB, GSK3B, HCAR2, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3 3.67966
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, ESR1, F3, FABP4, IDO1, KDR, MET, PPARA, PTGS2, SMAD3, TEK 3.66782
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, BCL2, CDC25B, EGFR, ESR1, F3, GSK3B, HSPA1A, INSR, KDR, MMP9, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.65115
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, BCL2, CA2, CDK6, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, FABP4, GSK3B, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PTGS2, PTPN1, SMAD3, SRC 3.64504
[BP] GO:0006468 protein phosphorylation BCL2, CDC25B, CDK6, CSNK2A1, EGFR, GSK3B, IGF1R, INSR, KDR, MET, NUAK1, SRC, TEK, TNKS 3.57887
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, GSK3B, HSPA1A, IDO1, MAOB, PDE5A, XDH 3.57291
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.56911
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DHFR, EGFR, INSR, MAOB, PTGS2, SMAD3 3.56904
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.5357
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, BCL2, CDC25B, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, F3, FABP4, GSK3B, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.50242
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, BCL2, CDC25B, DHFR, EGFR, ESR1, F3, GSK3B, HSPA1A, INSR, PDE5A, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 3.46352
[BP] GO:0018108 peptidyl-tyrosine phosphorylation EGFR, IGF1R, INSR, KDR, MET, SRC, TEK 3.44341
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR, MAOB 3.42743
[BP] GO:0009892 negative regulation of metabolic process ADORA1, BCL2, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GSK3B, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TNKS, TNKS2, XDH 3.42705
[BP] GO:0010810 regulation of cell-substrate adhesion BCL2, CDK6, GSK3B, KDR, SMAD3, SRC, TEK 3.42705
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, BCL2, CDK6, CYP1B1, FABP3, HSPA1A, IDO1, PDE5A, PTGS2, SMAD3, XDH 3.42705
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 3.41938
[BP] GO:0018212 peptidyl-tyrosine modification EGFR, IGF1R, INSR, KDR, MET, SRC, TEK 3.41827
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, BCL2, CA1, CSNK2A1, EGFR, F3, GPR35, GSK3B, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 3.35809
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, BCL2, CDC25B, EGFR, ESRRB, INSR, KDR, MMP9, PDE5A, PTGS2, PTPN1, SRC, TEK, XDH 3.35411
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 3.34493
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.32925
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, F3, FABP4, IDO1, KDR, MET, PTGS2, SMAD3 3.32925
[BP] GO:0003006 developmental process involved in reproduction ALPL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, PTGS2, SRC 3.31048
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.29781
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.29213
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, F3, GSK3B, HCAR2, IDO1, MMP9, PTGS2, SMAD3, SRC, XDH 3.26348
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 3.26348
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, F3, GSK3B, HCAR2, IDO1, MMP9, PTGS2, SMAD3, SRC, XDH 3.22712
[BP] GO:0051130 positive regulation of cellular component organization BCL2, ESR1, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 3.22178
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway EGFR, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 3.20819
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2 3.20819
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 3.20819
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FUT7, GBA2, GSK3B, HSPA1A, IDO1, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NUAK1, PDE5A, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 3.18993
[BP] GO:0051049 regulation of transport ACHE, ADORA1, BCL2, CA2, CA7, CYP19A1, EGFR, GPR35, GSK3B, HCAR2, HSPA1A, INSR, MAOB, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC 3.18446
[BP] GO:0009968 negative regulation of signal transduction BCL2, DUSP3, EGFR, ESR1, ESR2, GSK3B, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH 3.17782
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, CDK6, CYP1B1, EGFR, ESR1, GSK3B, IGF1R, INSR, MMP2, MMP9, PTGS2, SRC 3.16752
[BP] GO:0050793 regulation of developmental process BCL2, CA2, CDK6, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, GSK3B, IDO1, INSR, KDR, NUAK1, PDE5A, PPARA, PTGS2, SMAD3, SRC, TEK, TNKS2, XDH 3.13481
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, HSD11B2, MAOB, PTGS2 3.12381
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, GPR35, GSK3B, HCAR2, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PDE5A, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 3.11168
[BP] GO:0051240 positive regulation of multicellular organismal process BCL2, CA2, CYP1B1, EGFR, ESRRB, F3, HCAR2, HSPA1A, IDO1, KDR, MET, MMP9, PDE5A, PTGS2, SMAD3, SRC, TEK 3.09804
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, GPR35, MAOB, MMP9, PTGS2 3.09501
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AOX1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2, GSK3B, HSPA1A, IDO1, MAOB, PDE5A, SRC, XDH 3.09501
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 3.07809
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, BCL2, CDC25B, DUSP3, EGFR, FABP4, IGF1R, INSR, KDR, MMP9, PDE5A, PTGS2, PTPN1, SRC, TEK, XDH 3.06092
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, GSK3B, HCAR2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP9, NUAK1, PDE5A, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.02357
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.99379
[BP] GO:0032846 positive regulation of homeostatic process CA2, CA7, EGFR, HCAR2, PTGS2, TNKS, TNKS2 2.99171
[BP] GO:0051246 regulation of protein metabolic process ADORA1, BCL2, CDC25B, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, F3, FABP4, GSK3B, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.99171
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.99171
[BP] GO:0010942 positive regulation of cell death BCL2, CYP1B1, F3, GSK3B, HCAR2, IDO1, MMP9, PTGS2, SMAD3, SRC, XDH 2.98108
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.98108
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.98108
[BP] GO:0009115 None AOX1, XDH 2.95875
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, MET, SMAD3 2.94708
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, BCL2, CDC25B, EGFR, INSR, KDR, MMP9, PDE5A, PTGS2, PTPN1, SRC, TEK, XDH 2.93931
[BP] GO:0031399 regulation of protein modification process ADORA1, BCL2, CDC25B, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PDE5A, PTGS2, PTPN1, SRC, TEK, XDH 2.93178
[BP] GO:0007167 enzyme linked receptor protein signaling pathway EGFR, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 2.92149
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, XDH 2.92149
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.91762
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, GSK3B, HSD11B2, HSPA1A, IDO1, MMP2, MMP9, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 2.91762
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.90786
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTGS2 2.90666
[BP] GO:0051701 interaction with host EGFR, HSPA1A, INSR, MET, SMAD3, SRC 2.88194
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.88194
[BP] GO:0006091 generation of precursor metabolites and energy AKR1B1, AOX1, CYP19A1, CYP1A2, GSK3B, IDO1, MAOB, XDH 2.85866
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.85061
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, IGF1R, INSR, PDE5A, PTPN1, SRC 2.83095
[BP] GO:0010906 None ESRRB, GSK3B, INSR, PPARA, SRC 2.81732
[BP] GO:0006979 response to oxidative stress AKR1B1, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PTGS2, SRC 2.809
[BP] GO:0051098 regulation of binding BCL2, GSK3B, MET, MMP9, PPARA, SMAD3, SRC, TNKS 2.809
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2 2.80274
[BP] GO:1901361 None AOX1, CYP19A1, CYP1A1, CYP1A2, HSPA1A, IDO1, MAOB, PDE5A, XDH 2.79592
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.77114
[BP] GO:0016310 phosphorylation BCL2, CDC25B, CDK6, CSNK2A1, EGFR, GSK3B, IGF1R, INSR, KDR, MET, NUAK1, SRC, TEK, TNKS 2.74912
[BP] GO:0043408 regulation of MAPK cascade ADORA1, DUSP3, EGFR, IGF1R, INSR, KDR, PDE5A, PTPN1, SRC, TEK, XDH 2.7157
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.70403
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, GSK3B, HCAR2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP9, NUAK1, PDE5A, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.68114
[BP] GO:0000302 response to reactive oxygen species AKR1B1, BCL2, CYP1B1, EGFR, MMP9, SRC 2.67921
[BP] GO:0051338 regulation of transferase activity ADORA1, CDC25B, DUSP3, EGFR, FABP4, GSK3B, IGF1R, INSR, PDE5A, PTPN1, SRC, TEK, TNKS 2.67839
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2 2.67378
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.6704
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, HCAR2, PPARA, PTGS2, SRC, TEK 2.65745
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, EGFR, HCAR2, MET, PPARA, SMAD3 2.65579
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.64815
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.64815
[BP] GO:0010811 positive regulation of cell-substrate adhesion CDK6, GSK3B, KDR, SMAD3, TEK 2.64412
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, IDO1, PPARA, PTGS2 2.6406
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.63883
[BP] GO:0018193 peptidyl-amino acid modification BCL2, CSNK2A1, EGFR, F10, GSK3B, IGF1R, INSR, KDR, MET, SRC, TEK, TNKS 2.63883
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.63117
[BP] GO:0002682 regulation of immune system process ADORA1, BCL2, CA2, CDK6, CYP19A1, DUSP3, ESR1, ESRRA, HCAR2, HSPA1A, IDO1, MMP2, PDE5A, PTPN1, SMAD3, SRC 2.62237
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, CYP1B1, EGFR, MMP9, SRC 2.61502
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, MET, SMAD3, SRC 2.61133
[BP] GO:0044089 positive regulation of cellular component biogenesis ESR1, GSK3B, HSPA1A, KDR, MET, MMP1, SMAD3, SRC, TEK 2.6046
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.60439
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGS2 2.60439
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.60439
[BP] GO:0046110 None AOX1, XDH 2.58812
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.58812
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.58812
[BP] GO:0032496 response to lipopolysaccharide ALPL, CYP1A1, CYP1A2, IDO1, MAOB, PTGS2, SRC 2.54986
[BP] GO:2001233 regulation of apoptotic signaling pathway BCL2, GSK3B, HSPA1A, MMP9, PTGS2, PTPN1, SMAD3, SRC 2.54903
[BP] GO:0043434 None FABP3, HSD11B2, INSR, PPARA, PTGS2, SRC, TEK 2.54461
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.53265
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.53265
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.51734
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, EGFR, ESR1, MET, SMAD3, SRC 2.51444
[BP] GO:0035690 cellular response to drug AKR1B1, CDK6, CYP1B1, EGFR, KDR, PTGS2, SRC 2.51444
[BP] GO:0048511 rhythmic process BCL2, CSNK2A1, EGFR, ESR1, GSK3B, PPARA, SRC 2.49649
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.47753
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.47738
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.47738
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, EGFR, INSR, KDR, PDE5A, PTPN1, SRC, TEK, XDH 2.47421
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, BCL2, CA1, CA12, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, GPR35, GSK3B, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NUAK1, PDE5A, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.47
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, EGFR, GSK3B, IGF1R, INSR, MMP2, PTGS2, SRC 2.46117
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, EGFR, PTGS2 2.42963
[BP] GO:0010675 None ESRRB, GSK3B, INSR, PPARA, SRC 2.42963
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.42513
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, BCL2, CYP1A1, CYP1B1, KDR, MAOB, SRC 2.41485
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS2 2.40294
[BP] GO:0002237 response to molecule of bacterial origin ALPL, CYP1A1, CYP1A2, IDO1, MAOB, PTGS2, SRC 2.40294
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, PPARA, PTGS2, SRC, TEK 2.40294
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CYP1A1, EGFR, HSD11B2, PTGS2, SRC, TYR 2.39798
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, PTGS2 2.38906
[BP] GO:0007346 regulation of mitotic cell cycle BCL2, CDC25B, CDK6, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, SMAD3, TNKS 2.37997
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.37705
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.37672
[BP] GO:0043393 regulation of protein binding BCL2, GSK3B, MET, MMP9, PPARA, SRC 2.37211
[BP] GO:0070213 None TNKS, TNKS2 2.34557
[BP] GO:0006145 None AOX1, XDH 2.34557
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.34557
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC 2.34557
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2 2.33894
[BP] GO:0051894 None KDR, SMAD3, TEK 2.33414
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, BCL2, CA2, CYP19A1, EGFR, GSK3B, HCAR2, INSR, PTGS2, SMAD3, SRC 2.33058
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, PPARA 2.32302
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.31806
[BP] GO:0048869 cellular developmental process ACHE, ALPL, BCL2, CDC25B, CDK6, CYP1A1, EGFR, ESR1, ESRRB, FABP4, FUT7, GBA2, GSK3B, KDR, MET, MMP2, MMP9, PTGS2, SMAD3, SRC, TEK 2.30512
[BP] GO:0051054 positive regulation of DNA metabolic process EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 2.2995
[BP] GO:0050927 None F3, KDR, SMAD3 2.29057
[BP] GO:0045932 None ADORA1, PDE5A, PTGS2 2.29057
[BP] GO:0045913 None ESRRB, INSR, PPARA, SRC 2.28974
[BP] GO:0035239 tube morphogenesis BCL2, EGFR, ESR1, MET, SMAD3, SRC 2.28383
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.28383
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, EGFR, ESR1, GSK3B, IGF1R, INSR, MMP2, PTGS2, SMAD3, SRC 2.28251
[BP] GO:0031324 negative regulation of cellular metabolic process BCL2, CSNK2A1, DHFR, DUSP3, ESR1, ESR2, ESRRA, FABP4, GSK3B, HSPA1A, IGF1R, MET, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TNKS, TNKS2, XDH 2.27244
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, IDO1 2.27155
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PDE5A, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.27113
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, EGFR, GSK3B, IGF1R, INSR, MMP2, PTGS2, SRC 2.27028
[BP] GO:0050926 None F3, KDR, SMAD3 2.25554
[BP] GO:0005979 None ESRRB, GSK3B, INSR 2.25554
[BP] GO:1903393 None KDR, SMAD3, TEK 2.25554
[BP] GO:0010962 None ESRRB, GSK3B, INSR 2.25554
[BP] GO:0009991 response to extracellular stimulus ALPL, BCL2, CYP1A1, EGFR, HSD11B2, PTGS2, SRC, TYR 2.25002
[BP] GO:0009607 response to biotic stimulus ALPL, BCL2, CDK6, CYP1A1, CYP1A2, GSK3B, IDO1, MAOB, PTGS2, SMAD3, SRC 2.21854
[BP] GO:0019538 protein metabolic process ACHE, ALPL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, ESR1, F10, F3, FUT7, GSK3B, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 2.21667
[BP] GO:0010605 negative regulation of macromolecule metabolic process CSNK2A1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GSK3B, HSPA1A, IGF1R, KDR, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TNKS, TNKS2, XDH 2.21665
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.21313
[BP] GO:0032868 None FABP3, HSD11B2, INSR, PPARA, SRC 2.20778
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DUSP3, EGFR, FABP4, IGF1R, INSR, PDE5A, PTPN1, SRC, TEK 2.19983
[BP] GO:0031334 positive regulation of protein complex assembly ESR1, GSK3B, HSPA1A, MET, MMP1, SRC 2.19983
[BP] GO:0051726 regulation of cell cycle BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PTGS2, SMAD3, SRC, TNKS 2.19802
[BP] GO:0009896 positive regulation of catabolic process CSNK2A1, ESRRB, GSK3B, HSPA1A, INSR, KDR, PPARA, PTPN1 2.17867
[BP] GO:0043696 None CDK6, ESRRB 2.17867
[BP] GO:0043697 None CDK6, ESRRB 2.17867
[BP] GO:0010641 None F3, SRC 2.17867
[BP] GO:0007598 None F10, F3 2.17867
[BP] GO:0050678 None CDK6, EGFR, F3, KDR, SMAD3, TEK, XDH 2.17867
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, GBA2, IDO1, PPARA, PTGS2, TYR 2.1689
[BP] GO:2000026 regulation of multicellular organismal development BCL2, CA2, CDK6, CYP1B1, EGFR, ESR1, ESRRA, F3, GSK3B, IDO1, INSR, KDR, PTGS2, SMAD3, SRC, TEK, XDH 2.16776
[BP] GO:0032845 None ADORA1, BCL2, SRC, TNKS, TNKS2 2.15409
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.14066
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, BCL2, CDC25B, CSNK2A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, GSK3B, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP9, NUAK1, PDE5A, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.14066
[BP] GO:0051336 regulation of hydrolase activity CSNK2A1, EGFR, ESR1, F3, GSK3B, HSPA1A, MMP9, NUAK1, PTGS2, PTPN1, SMAD3, SRC, XDH 2.13518
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, GSK3B, TNKS 2.10659
[BP] GO:0018958 None AKR1B1, BCL2, MAOB, TYR 2.10659
[BP] GO:0051128 regulation of cellular component organization BCL2, CSNK2A1, EGFR, ESR1, ESR2, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 2.10423
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.10335
[BP] GO:0070873 None ESRRB, GSK3B, INSR 2.10335
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, BCL2, CDC25B, CSNK2A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, GSK3B, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP9, NUAK1, PDE5A, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.10283
[BP] GO:0008217 None ADORA1, HSD11B2, PPARA, PTGS2, SMAD3 2.09645
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FUT7, GBA2, GPR35, GSK3B, HCAR2, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NUAK1, PDE5A, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 2.09039
[BP] GO:0031401 positive regulation of protein modification process ADORA1, BCL2, CDC25B, EGFR, INSR, KDR, MMP9, PDE5A, PTGS2, PTPN1, SRC, TEK, XDH 2.07367
[BP] GO:1901890 None KDR, SMAD3, TEK 2.06842
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.06842
[BP] GO:0043255 regulation of carbohydrate biosynthetic process ESRRB, GSK3B, INSR, PPARA 2.05598
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, EGFR, ESR1, PTGS2, SRC 2.04255
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, F3, KDR, PTGS2, TEK 2.04255
[BP] GO:1903426 None EGFR, INSR, PTGS2, SMAD3 2.04255
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.04255
[BP] GO:0007162 negative regulation of cell adhesion CYP1B1, DUSP3, IDO1, PDE5A, PPARA, SRC 2.04255
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.04255
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.04255
[BP] GO:0046113 None AOX1, XDH 2.04255
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2 2.04034
[BP] GO:0003018 None ADORA1, EGFR, PTGS2, SRC, TEK 2.04034
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, BCL2, CDK6, CYP1A1, CYP1A2, EGFR, HSD11B2, IDO1, MAOB, PTGS2, SMAD3, SRC, TYR 2.03828
[BP] GO:0051186 None AKR1B1, AKR1B10, CYP1A1, CYP1A2, DHFR, EGFR, MAOB, PTGS2 2.03828
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, EGFR, ESR1, MET, SMAD3, SRC 2.0283
[BP] GO:0032885 regulation of polysaccharide biosynthetic process ESRRB, GSK3B, INSR 2.01018
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, BCL2, CA1, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FUT7, GBA2, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IDO1, INSR, KDR, MAOB, MMP2, MMP9, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TNKS, TNKS2, TYR, XDH 3.09501
[CC] GO:0031233 None CA4, F10, F3 2.53265
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.04255
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, BCL2, CA12, CA14, CA2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, F10, F3, FUT7, GBA2, GPR35, GSK3B, HCAR2, HSD11B1, HSD11B2, HSD17B2, IGF1R, INSR, KDR, MAOB, MET, MMP2, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TYR 2.03828
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGS2 1.96102
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, F10, F3, FUT7, GBA2, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NUAK1, PDE5A, PTGS2, PTPN1, SRC, TEK, TNKS, TNKS2, TYR, XDH 11.7383
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA, PTPN1, SMAD3, TNKS, TYR, XDH 10.0473
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, GSK3B, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NUAK1, PDE5A, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 9.8807
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 8.15975
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, MAOB, PTGS2, TYR, XDH 7.76567
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, HSD11B2, HSD17B1, IDO1, MAOB, PTGS2, SRC, XDH 5.69958
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA, PTPN1, SMAD3, TNKS 5.64342
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.28868
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.08266
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity EGFR, IGF1R, INSR, KDR, MET, TEK 4.83802
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, MAOB, XDH 4.76486
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, IDO1, MMP1, MMP2, MMP9, NUAK1, PDE5A, PPARA, PTGS2, PTPN1, SMAD3, TNKS, TNKS2, TYR, XDH 4.4404
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.41821
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, PTGS2, SRC 4.33631
[MF] GO:0019199 transmembrane receptor protein kinase activity EGFR, IGF1R, INSR, KDR, MET, TEK 4.30077
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, PTGS2, SRC 4.13835
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 4.10757
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, IDO1, MMP1, MMP2, MMP9, NUAK1, PDE5A, PPARA, PTGS2, PTPN1, SMAD3, TNKS, TNKS2, TYR, XDH 3.98473
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.98473
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.98473
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.81624
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.7977
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.65754
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.64504
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.58187
[MF] GO:0008144 drug binding ACHE, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PPARA, SRC, TEK 3.57291
[MF] GO:0004713 protein tyrosine kinase activity EGFR, IGF1R, INSR, KDR, MET, SRC, TEK 3.51116
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.47777
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.44325
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.42705
[MF] GO:0036094 small molecule binding ADORA1, AOX1, CDK6, CSNK2A1, DHFR, EGFR, FABP3, FABP4, GSK3B, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE5A, SRC, TEK, XDH 3.16752
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, TEK 3.08049
[MF] GO:0004672 protein kinase activity CDK6, CSNK2A1, EGFR, GSK3B, IGF1R, INSR, KDR, MET, NUAK1, SRC, TEK 3.01542
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 3.01008
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, ESRRB, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SMAD3, SRC 2.98223
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.95875
[MF] GO:0003845 None HSD11B1, HSD11B2 2.95875
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TYR 2.91762
[MF] GO:0008289 lipid binding ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA 2.91762
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, CDK6, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, TEK 2.91547
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.8888
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.85703
[MF] GO:0019899 enzyme binding BCL2, CDC25B, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, GSK3B, HSPA1A, MET, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS2 2.84006
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.83575
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.80855
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, ESRRB, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SMAD3, SRC 2.79355
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, SMAD3, TEK 2.61133
[MF] GO:0000166 nucleotide binding AOX1, CDK6, CSNK2A1, DHFR, EGFR, GSK3B, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE5A, SRC, TEK, XDH 2.58812
[MF] GO:1901265 nucleoside phosphate binding AOX1, CDK6, CSNK2A1, DHFR, EGFR, GSK3B, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE5A, SRC, TEK, XDH 2.58812
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7 2.58599
[MF] GO:0004872 receptor activity ADORA1, ADORA3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, TEK 2.56587
[MF] GO:0043168 anion binding AOX1, CDK6, CSNK2A1, DHFR, EGFR, F10, F3, FABP3, FABP4, GSK3B, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE5A, SRC, TEK, XDH 2.547
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor CDK6, CSNK2A1, EGFR, GSK3B, IGF1R, INSR, KDR, MET, NUAK1, SRC, TEK 2.43972
[MF] GO:0042802 identical protein binding ACHE, AOX1, BCL2, CSNK2A1, EGFR, ESR1, ESR2, IGF1R, KDR, MAOB, MET, MMP9, PTGS2, SMAD3, TYR, XDH 2.36601
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.34557
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.31383
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX5, IDO1, PTGS2 2.25554
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX5, IDO1, PTGS2 2.21313
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.17867
[MF] GO:0043559 insulin binding IGF1R, INSR 2.17867
[MF] GO:0016301 kinase activity CDK6, CSNK2A1, EGFR, GSK3B, IGF1R, INSR, KDR, MET, NUAK1, SRC, TEK 2.17661
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.06842
[MF] GO:0008013 beta-catenin binding CSNK2A1, ESR1, GSK3B, SMAD3 2.04255
[MF] GO:0140096 catalytic activity, acting on a protein CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, F10, F3, GSK3B, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PTPN1, SRC, TEK 2.04255
[MF] GO:0004064 arylesterase activity CA1, CA2 2.04255
[MF] GO:0043546 None AOX1, XDH 2.04255


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 11.1499
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 9.2007
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.4473
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 9.2007
Metabolic pathways_Homo sapiens_hsa01100 MAOB, AKR1B1, PTGS2, TYR, GBA2, CYP19A1, DHFR, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, IDO1 6.8058
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 7.021
Pathways in cancer_Homo sapiens_hsa05200 GSK3B, CDK6, SMAD3, MMP1, MMP2, BCL2, PTGS2, MMP9, MET, EGFR, IGF1R 6.022
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, EGFR, ESR2, HSPA1A 6.1791
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 5.3696
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, CDK6, INSR, KDR, BCL2, TEK, MET, EGFR, IGF1R 4.7158
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.4574
Focal adhesion_Homo sapiens_hsa04510 GSK3B, SRC, KDR, BCL2, MET, EGFR, IGF1R 4.3084
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 4.2506
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 4.2506
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.7324
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, BCL2, TEK, EGFR, IGF1R 3.7324
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2 4.1618
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.2135
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1, PTGS2 3.5611
Melanoma_Homo sapiens_hsa05218 CDK6, MET, EGFR, IGF1R 3.2135
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, SRC, ESR1, ESR2 3.2135
Hepatitis B_Homo sapiens_hsa05161 CDK6, SMAD3, SRC, BCL2, MMP9 3.1753
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2264
Prostate cancer_Homo sapiens_hsa05215 GSK3B, BCL2, EGFR, IGF1R 2.9481
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, BCL2, F3 2.7537
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.2135
Insulin resistance_Homo sapiens_hsa04931 PTPN1, GSK3B, INSR, PPARA 2.643
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.3493
Measles_Homo sapiens_hsa05162 GSK3B, CDK6, CSNK2A1, HSPA1A 2.3377
Cell cycle_Homo sapiens_hsa04110 GSK3B, CDK6, SMAD3, CDC25B 2.4462
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, SMAD3, ESRRB, IGF1R 2.3133
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1, PDE5A 2.1244
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.3338
Glioma_Homo sapiens_hsa05214 CDK6, EGFR, IGF1R 2.3133
Colorectal cancer_Homo sapiens_hsa05210 GSK3B, SMAD3, BCL2 2.3259
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.3133
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, CSNK2A1, BCL2, HSPA1A 1.8841
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, SMAD3, EGFR 2.305
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.9755
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, SRC, EGFR 2.0216
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2782
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2, PTGS2 2.0263
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.3133
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOB, CYP1A2, AOX1 2.2703
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB, AOX1, TYR 2.9481
Serotonergic synapse_Homo sapiens_hsa04726 MAOB, ALOX5, PTGS2 1.767
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.9582
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.6117
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, SRC, ESR1 1.7286
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.7286
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.7162
Hepatitis C_Homo sapiens_hsa05160 GSK3B, PPARA, EGFR 1.6117
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B, SMAD3, CSNK2A1 1.5539
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B, INSR, PPARA 1.4962
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, GSK3B, INSR 1.5719
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2, EGFR 1.4572
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 MMP9, MET, IGF1R 1.3399
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1, PPARA 1.2452
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 KDR, MET, EGFR 0.9897
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1 0.9638
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 1.0136
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 1.0119
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0929
Melanogenesis_Homo sapiens_hsa04916 GSK3B, TYR 1.0825
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.1201
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B, BCL2 0.978
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9805
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.8784
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.9626
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8955
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.1489
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, SMAD3 1.2874
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.161
Dopaminergic synapse_Homo sapiens_hsa04728 GSK3B, MAOB 0.9473
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 0.9543
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.8002
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B, SMAD3 0.8514
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, AOX1 0.8407
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2452
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3479
Purine metabolism_Homo sapiens_hsa00230 PDE5A, XDH 0.7875
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.7066
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.354
Influenza A_Homo sapiens_hsa05164 GSK3B, HSPA1A 0.7875
Alcoholism_Homo sapiens_hsa05034 MAOB 0.354
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7833
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MET, EGFR 1.3447
Alzheimer's disease_Homo sapiens_hsa05010 GSK3B 0.3709
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, SRC 0.7562
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4106
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.7033
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.2415
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4268
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4393
HTLV-I infection_Homo sapiens_hsa05166 GSK3B, SMAD3 0.616
Platelet activation_Homo sapiens_hsa04611 SRC 0.4666
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4665
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, EGFR 1.4593
Endometrial cancer_Homo sapiens_hsa05213 GSK3B, EGFR 1.507
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.5214
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.5264
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5264
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B 0.5214
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5287
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5342
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5333
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.5264
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4296
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5473
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGS2 1.3953
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5538
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5683
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5525
Peroxisome_Homo sapiens_hsa04146 XDH 0.5696
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B 0.6094
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6094
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5952
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6073
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.616
Bile secretion_Homo sapiens_hsa04976 CA2 0.6137
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6256
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.616
Amphetamine addiction_Homo sapiens_hsa05031 MAOB 0.6231
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6282
Shigellosis_Homo sapiens_hsa05131 SRC 0.6282
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.6282
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6494
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, INSR 1.7115
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6803
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.6803
Malaria_Homo sapiens_hsa05144 MET 0.7049
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.7033
Cocaine addiction_Homo sapiens_hsa05030 MAOB 0.7049
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOB 0.704
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8781
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7066
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.7058
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.704
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.7058
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7066
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.7066
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7479
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8315
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.791
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.791
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOB 0.7562
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0515
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8639
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8283
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8474
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8474
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8706
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8639
Folate biosynthesis_Homo sapiens_hsa00790 DHFR, ALPL 2.3493
Histidine metabolism_Homo sapiens_hsa00340 MAOB 0.8948
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB 0.9897
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 0.9543
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.978
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1753
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3485


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)