TCM Prescription: Jin Zhi Jie Yin Han Shu Oral Liquid



Prescription Description
Prescription IDTCMF6973
Pinyin NameJin Zhi Jie Yin Han Shu Ye
Chinese Name金栀洁龈含漱液
English NameJin Zhi Jie Yin Han Shu Oral Liquid
Function Description清热解毒, 消肿止痛。用于缓解牙龈, 牙周及粘膜炎症所致的肿痛。
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1847 Lonicerae flos 山银花 TCMH1847
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH188 Mentha haplocalyx 薄荷 TCMH188 HM595443
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH1215 Sophora flavescens 苦参 TCMH1215 ITSAM449-14
TCMH949 Phellodendron amurense 黄柏 TCMH949 ITSAM1586-14
TCMH2494 Artemisia capillaris 茵陈蒿 TCMH2494 ITSAN1371-14
TCMH448 Fructus kochiae 地肤子 TCMH448
TCMH1920 Acorus tatarinowii 石菖蒲 TCMH1920 ITSAI4409-14
TCMH517 Angelica pubescens 独活 TCMH517 ITSAF170-14
TCMH1866 Cnidium monnieri 蛇床子 TCMH1866 ITSAL2575-14
TCMH12 Artemisia argyi 艾叶 TCMH12 ITSAE2504-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT248 CXCL8 Interleukin-8 Unclassified P10145
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT594 PTAFR Platelet activating factor receptor GPCR P25105
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HMGCR, HSD17B1, HSPA1A, INSR, KDR, KIT, MET, MIF, PPARA, PTAFR, PTGS1, PTGS2, SLC1A1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 13.4176
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, PTGS2, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 13.4176
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, PTGS2, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 13.366
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, AKR1C3, APP, BCL2, CSNK2A1, CXCL8, CYP1B1, DNMT1, DRD2, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, PTAFR, PTGS1, PTGS2, SMAD3, SRC, TEK, TERT, XDH 13.103
[BP] GO:0010647 positive regulation of cell communication AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PTGS2, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 12.3805
[BP] GO:0010033 response to organic substance AKR1B1, AKR1C3, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, PPARA, PTAFR, PTGS2, SMAD3, SRC, TEK 12.3805
[BP] GO:0023056 positive regulation of signaling AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PTGS2, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 12.3805
[BP] GO:0009719 response to endogenous stimulus AKR1B1, AKR1C3, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CXCL8, CYP1A2, DNMT1, DRD1, EGFR, ESR1, ESRRA, FABP3, FLT3, GRM5, IGF1R, INSR, KIT, MMP2, PPARA, PTAFR, PTGS2, SMAD3, SRC, TEK 12.1639
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, EGFR, ESR1, ESRRA, FABP3, GRIK5, GRM5, HMGCR, IGF1R, INSR, MMP2, MMP9, PPARA, PTAFR, PTGS2, SRC, TEK 12.0424
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, PPARA, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 11.8802
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, EGFR, ESR1, FABP3, FABP4, FUT7, HMGCR, HSD17B1, KIT, MET, MIF, PPARA, PTGS1, PTGS2 11.8802
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGS1, PTGS2 10.8439
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 10.7493
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTAFR, PTGS2, SLC1A1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 10.5875
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGS1, PTGS2 10.5539
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 10.5166
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AKR1C3, ALOX15, ALPL, APP, AXL, BCL2, CXCL8, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, PTAFR, PTGS2, SMAD3, SRC, TERT 10.5123
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, EGFR, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PTGS2, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 10.3289
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, KIT, MMP9, PTGS2, SRC, TERT 10.1729
[BP] GO:0030334 regulation of cell migration ADORA3, APP, BCL2, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 10.0231
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CSNK2A1, CXCL8, CYP1B1, DRD2, EGFR, ESRRA, F3, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, KIT, MET, MIF, MMP12, MMP2, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 9.99071
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, EGFR, FABP3, FABP4, FUT7, HMGCR, KIT, MET, MIF, PPARA, PTGS1, PTGS2 9.87746
[BP] GO:0048583 regulation of response to stimulus ABCB1, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP2, MMP9, NUAK1, PPARA, PTAFR, PTGS2, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 9.62475
[BP] GO:2000145 regulation of cell motility ADORA3, APP, BCL2, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 9.51479
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, CXCL8, DRD1, EGFR, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 9.50713
[BP] GO:0071310 cellular response to organic substance AKR1B1, AKR1C3, ALOX15, ALPL, APP, AXL, BCL2, CXCL8, CYP1A1, CYP1B1, DNMT1, DRD1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, INSR, KDR, KIT, MMP2, PTAFR, PTGS2, SMAD3, SRC 9.41712
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, CXCL8, DRD1, EGFR, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 9.27632
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 9.22914
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, NUAK1, PTGS2, SRC, TEK, XDH 9.18786
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, CXCL8, DRD1, EGFR, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 9.11318
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APP, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FUT7, HMGCR, HSPA1A, MIF, PIM1, PPARA, PTAFR, PTGS1, PTGS2, XDH 9.09506
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CYP1B1, DRD2, EGFR, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, KIT, MET, MIF, PTGS2, SRC, TEK, XDH 8.9914
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AKR1C3, BCL2, CSNK2A1, DRD2, EGFR, ESR1, F3, FLT3, HMGCR, IGF1R, INSR, KDR, KIT, MIF, MMP12, MMP2, MMP9, PIM1, PTAFR, PTGS2, TEK, TERT 8.98986
[BP] GO:0040012 regulation of locomotion ADORA3, APP, BCL2, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 8.94166
[BP] GO:0051270 regulation of cellular component movement ADORA3, APP, BCL2, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 8.92754
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, CXCL8, DRD1, EGFR, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 8.92754
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, APP, BACE1, CA2, CA7, DRD1, DRD2, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, KIT, PTGS2 8.86458
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, APP, BACE1, CA2, CA7, DRD1, DRD2, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, KIT, PTGS2 8.86458
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGS1, PTGS2 8.84602
[BP] GO:0009725 response to hormone AKR1B1, AKR1C3, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, INSR, KIT, PPARA, PTAFR, PTGS2, SRC, TEK 8.70963
[BP] GO:0051716 cellular response to stimulus AKR1B1, AKR1C3, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CXCL8, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, KIT, MIF, MMP2, MMP9, NUAK1, PTAFR, PTGS2, SMAD3, SRC, TERT 8.5042
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA3, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, GPR35, GRIK5, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PPARA, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 8.50379
[BP] GO:0009966 regulation of signal transduction AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CXCL8, CYP1B1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, PTGS2, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 8.48774
[BP] GO:0019220 regulation of phosphate metabolic process ALOX15, APP, BCL2, DRD1, DRD2, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, PPARA, PTAFR, PTGS2, SMAD3, SRC, TEK, XDH 8.32654
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.26473
[BP] GO:0051174 regulation of phosphorus metabolic process ALOX15, APP, BCL2, DRD1, DRD2, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, PPARA, PTAFR, PTGS2, SMAD3, SRC, TEK, XDH 8.26473
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 8.19509
[BP] GO:0014070 response to organic cyclic compound AKR1C3, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESRRA, FLT3, PTAFR, PTGS2, SRC, TEK 8.06103
[BP] GO:0031325 positive regulation of cellular metabolic process AKR1C3, ALOX15, APP, AURKB, BCL2, DNMT1, DRD1, DRD2, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PPARA, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 8.06103
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PPARA, PTGS1, PTGS2 7.95259
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ALOX15, APP, AURKB, BCL2, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PPARA, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 7.90131
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, HMGCR, HSD17B1 7.8104
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, PIM1, SRC, TEK 7.80535
[BP] GO:0009893 positive regulation of metabolic process AKR1C3, ALOX15, APP, AURKB, BCL2, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PPARA, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 7.72566
[BP] GO:0010038 response to metal ion AKR1C3, ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, KIT, MMP9, PTGS2, TERT 7.56415
[BP] GO:0010941 regulation of cell death AKR1B1, AKR1C3, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GRIK5, HMGCR, HSPA1A, IGF1R, KDR, KIT, MET, MIF, MMP9, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, XDH 7.54292
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AKR1C3, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GRIK5, HMGCR, HSPA1A, IGF1R, KDR, KIT, MET, MIF, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK, TERT, XDH 7.54104
[BP] GO:0007166 cell surface receptor signaling pathway ADORA3, APP, AXL, BCL2, CSNK2A1, CXCL8, DRD2, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, KIT, MET, MIF, MMP2, MMP9, PTAFR, SMAD3, SRC, TEK, TNKS, TNKS2 7.51559
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA3, APP, AURKB, BCL2, CSNK2A1, CXCL8, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KIT, MET, MIF, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT, TNKS, XDH 7.48475
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PIM1, PPARA, PTGS2, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 7.45269
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP2, NUAK1, PIM1, PPARA, PTAFR, PTGS1, PTGS2, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 7.43058
[BP] GO:0010604 positive regulation of macromolecule metabolic process ALOX15, APP, AURKB, BCL2, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PPARA, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 7.42697
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, APP, BCL2, DRD1, DRD2, EGFR, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, KIT, MIF, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, XDH 7.38384
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, APP, BCL2, DRD1, DRD2, EGFR, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, KIT, MIF, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, XDH 7.38384
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic DRD1, DRD2, EGFR, GRM1, GRM3, GRM5, GRM8, PTGS2 7.35883
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTGS1, PTGS2, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 7.35331
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CSNK2A1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PTAFR, PTGS2, PTPRS, SRC, TEK, TNKS, XDH 7.23859
[BP] GO:0080134 regulation of response to stress ABCB1, APP, CYP19A1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, F3, FABP4, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP2, NUAK1, PPARA, PTGS2, PTPRS, SMAD3, SRC, TEK, TERT, XDH 7.23473
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRB, F3, FABP4, GRM1, GRM5, GRM8, HMGCR, IGF1R, INSR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTAFR, PTGS2, SMAD3, SRC, TEK, TNKS2 7.17002
[BP] GO:0048585 negative regulation of response to stimulus ALOX15, BCL2, CXCL8, CYP19A1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTGS2, PTPRS, SMAD3, SRC, TEK, TERT, XDH 7.10251
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7, GRM5, PTAFR 7.09093
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APP, AXL, CXCL8, CYP1B1, DNMT1, DRD1, EGFR, ESR1, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, PTAFR, PTGS2, SRC 7.06978
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HMGCR, HSPA1A, IGF1R, KDR, KIT, MET, MIF, MMP9, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 7.02179
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 6.98405
[BP] GO:0050790 regulation of catalytic activity ADORA3, APP, AURKB, BCL2, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KIT, MIF, MMP9, NUAK1, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT, TNKS, XDH 6.96389
[BP] GO:0010648 negative regulation of cell communication ACHE, BCL2, CXCL8, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPRS, SMAD3, SRC, TERT, XDH 6.94857
[BP] GO:0023057 negative regulation of signaling ACHE, BCL2, CXCL8, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPRS, SMAD3, SRC, TERT, XDH 6.9332
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 6.9332
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AKR1C3, APP, CXCL8, DNMT1, DRD1, EGFR, ESR1, FLT3, GRM5, IGF1R, INSR, KIT, MMP2, PTAFR, PTGS2, SMAD3, SRC 6.92222
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HMGCR, HSPA1A, IGF1R, KDR, KIT, MET, MIF, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK, TERT 6.92154
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, EGFR, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MIF, MMP12, MMP2, MMP9, NUAK1, PPARA, PTAFR, PTGS1, PTGS2, SMAD3, SRC, TEK, TERT 6.88522
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AXL, BCL2, CA2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, INSR, KDR, KIT, PPARA, PTPRS, SMAD3, SRC, TEK 6.88007
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CXCL8, CYP1B1, DRD2, EGFR, ESRRB, F3, HMGCR, HSPA1A, KDR, KIT, MET, MIF, MMP12, MMP9, PIM1, PTAFR, PTGS2, SLC1A1, SMAD3, SRC, TEK, TERT 6.88007
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CSNK2A1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PTAFR, PTGS2, PTPRS, SRC, TEK, TNKS, XDH 6.86052
[BP] GO:0009628 response to abiotic stimulus AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, EGFR, GRM1, HMGCR, HSPA1A, KIT, MMP2, PPARA, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT 6.66361
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTAFR, PTGS2, TERT 6.59927
[BP] GO:0033993 response to lipid AKR1C3, ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, PTAFR, PTGS2, SRC 6.59117
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PIM1, PPARA, PTGS2, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 6.56785
[BP] GO:0051239 regulation of multicellular organismal process ADORA3, APP, AXL, BCL2, CA2, CXCL8, CYP1B1, DRD2, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PIM1, PTAFR, PTGS2, PTPRS, SLC1A1, SMAD3, SRC, TEK, TERT, TNKS2, XDH 6.49786
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, DRD2, EGFR, F3, INSR, KIT, MET, SRC, TEK, XDH 6.48943
[BP] GO:0051247 positive regulation of protein metabolic process ALOX15, APP, BCL2, CSNK2A1, DNMT1, DRD2, DYRK1A, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, INSR, KDR, KIT, MIF, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, XDH 6.4258
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AKR1C3, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GRIK5, HMGCR, HSPA1A, IGF1R, KDR, MIF, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK, TERT, XDH 6.37256
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, HMGCR, PTAFR 6.34025
[BP] GO:0032270 positive regulation of cellular protein metabolic process ALOX15, APP, BCL2, DNMT1, DRD2, DYRK1A, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, INSR, KDR, KIT, MIF, MMP9, PTAFR, PTGS2, SMAD3, SRC, TEK, XDH 6.22824
[BP] GO:0032502 developmental process ACHE, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HMGCR, INSR, KDR, KIT, MET, MIF, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPRS, SMAD3, SRC, TEK, TERT, TNKS2 6.14844
[BP] GO:0032101 regulation of response to external stimulus CXCL8, CYP19A1, DRD1, DRD2, EGFR, ESR1, F3, FABP4, HMGCR, KDR, MET, MIF, MMP12, PPARA, PTGS2, PTPRS, SMAD3, TEK 6.06587
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD17B1, PTGS1, PTGS2, XDH 5.95986
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD1, DRD2, EGFR, HSPA1A 5.93746
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ALOX15, APP, AXL, BCL2, CA2, CA7, CYP19A1, DRD1, DRD2, EGFR, GPR35, GRIK5, GRM5, HMGCR, HSPA1A, INSR, MIF, MMP12, MMP9, PPARA, PTAFR, PTGS2, SMAD3, SRC, TERT 5.88438
[BP] GO:0042592 homeostatic process AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, DRD1, DRD2, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, INSR, MET, SMAD3, SRC, TERT 5.83405
[BP] GO:0042325 regulation of phosphorylation ALOX15, APP, BCL2, DRD1, DRD2, DUSP3, EGFR, ESRRB, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KDR, KIT, MIF, MMP9, PPARA, PTGS2, SRC, TEK, XDH 5.71866
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, DRD1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TNKS 5.67722
[BP] GO:0031399 regulation of protein modification process ALOX15, APP, BCL2, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, PTGS2, SRC, TEK, XDH 5.67722
[BP] GO:0007165 signal transduction ADORA3, AKR1B1, AKR1C3, APP, AXL, BCL2, CA2, CSNK2A1, CXCL8, CYP1B1, DNMT1, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, KIT, MET, MIF, MMP2, MMP9, NUAK1, PIM1, PPARA, PTAFR, SMAD3, SRC, TEK, TNKS, TNKS2 5.66774
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, DRD1, DRD2, EGFR, HMGCR, KDR, MIF, PTGS2, SRC, TNKS, TNKS2 5.64216
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, EGFR, ESR1, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, INSR, MET, SMAD3 5.62818
[BP] GO:0032787 None AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PPARA, PTGS1, PTGS2 5.60294
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, DNMT1, DRD2, ESR1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 5.58446
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, EGFR, F3, INSR, KIT, MET, SRC, TEK 5.53697
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HMGCR, HSPA1A, IGF1R, KDR, MIF, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK, TERT 5.53697
[BP] GO:0009968 negative regulation of signal transduction BCL2, CXCL8, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPRS, SMAD3, SRC, TERT, XDH 5.51582
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTGS1, PTGS2, PTPRS, SLC1A1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TUBB3, XDH 5.51582
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DNMT1, DRD1, DRD2, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PTAFR, PTGS2, SRC, TEK 5.50317
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1 5.50013
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.41647
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC 5.41282
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CBR1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTGS1, PTGS2, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 5.41056
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 5.36496
[BP] GO:0042327 positive regulation of phosphorylation ALOX15, APP, BCL2, DRD2, EGFR, ESRRB, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, KIT, MIF, MMP9, PTGS2, SRC, TEK, XDH 5.34938
[BP] GO:0015701 bicarbonate transport CA12, CA14, CA2, CA4, CA7, CA9 5.31807
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, ALPL, APP, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FLT3, PTAFR, PTGS2, SRC 5.31756
[BP] GO:0043410 positive regulation of MAPK cascade ALOX15, APP, DRD2, EGFR, FLT3, GRM1, HMGCR, INSR, KDR, KIT, MIF, SRC, TEK, XDH 5.30389
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AXL, BCL2, CA2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESRRA, ESRRB, FLT3, INSR, KDR, KIT, MMP9, PIM1, PPARA, PTGS2, PTPRS, SMAD3, SRC, TEK 5.29018
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.25541
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, DUSP3, DYRK1A, ESR1, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP9, PTGS2, SRC, XDH 5.25541
[BP] GO:0044093 positive regulation of molecular function ABCB1, APP, AURKB, BCL2, DRD2, EGFR, ESR1, ESR2, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, KIT, MET, MIF, MMP9, PTAFR, SMAD3, SRC, TEK, TERT, TNKS, XDH 5.23066
[BP] GO:0001932 regulation of protein phosphorylation ALOX15, APP, BCL2, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KDR, KIT, MIF, MMP9, PTGS2, SRC, TEK, XDH 5.13076
[BP] GO:0043408 regulation of MAPK cascade ALOX15, APP, DRD2, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, KDR, KIT, MIF, SRC, TEK, XDH 5.10478
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DNMT1, DRD1, DRD2, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PTAFR, PTGS2, SRC, TEK 5.08042
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, HMGCR 5.06474
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DRD2, EGFR, PPARA, SMAD3 5.00098
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTAFR, PTGS2, TERT 4.98977
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DRD2, DUSP3, ESR1, FABP4, GPR35, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, SRC, TNKS 4.98419
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCL2, CA9, CYP1A1, CYP1B1, DRD1, DRD2, EGFR, FABP3, HMGCR, KDR, PTAFR, PTGS2, SRC 4.97331
[BP] GO:0001934 positive regulation of protein phosphorylation ALOX15, APP, BCL2, DRD2, EGFR, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, KIT, MIF, MMP9, PTGS2, SRC, TEK, XDH 4.95302
[BP] GO:0032268 regulation of cellular protein metabolic process ALOX15, APP, BCL2, CSNK2A1, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, PTAFR, PTGS2, SMAD3, SRC, TEK, XDH 4.93687
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1 4.89381
[BP] GO:0019371 None AKR1C3, CBR1, PTGS1, PTGS2 4.88555
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, APP, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, EGFR, INSR, MIF, MMP12, PTAFR, PTGS2, SMAD3, SRC, TERT 4.85019
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DNMT1, DRD1, EGFR, GRM5, IGF1R, INSR, MMP2, PTAFR, PTGS2, SRC 4.82867
[BP] GO:0007612 None APP, DRD1, DRD2, GRM5, HMGCR, INSR, KIT, PTGS2 4.81338
[BP] GO:0031401 positive regulation of protein modification process ALOX15, APP, BCL2, DNMT1, DRD2, DYRK1A, EGFR, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, KIT, MIF, MMP9, PTGS2, SRC, TEK, XDH 4.7664
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, EGFR, GRIK5, INSR, PTGS2, SLC1A1, SMAD3 4.7664
[BP] GO:0046686 response to cadmium ion AKR1C3, CYP1A2, EGFR, KIT, MMP9, TERT 4.76113
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 4.70842
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, EGFR, HMGCR, KDR, MIF, SRC, TEK 4.69051
[BP] GO:0009892 negative regulation of metabolic process AKR1C3, APP, AURKB, BCL2, CSNK2A1, DNMT1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTGS2, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 4.6871
[BP] GO:0080090 regulation of primary metabolic process ADORA3, AKR1C3, ALOX15, APP, AURKB, BCL2, CA9, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 4.67964
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 4.59938
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA3, AKR1C3, ALOX15, APP, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 4.58069
[BP] GO:0071248 cellular response to metal ion AKR1C3, ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 4.56335
[BP] GO:0031324 negative regulation of cellular metabolic process AKR1C3, APP, AURKB, BCL2, CSNK2A1, DNMT1, DRD2, DUSP3, DYRK1A, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTGS2, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 4.54647
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, DUSP3, EGFR, HMGCR, KDR, MIF, SRC, TEK 4.50783
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DNMT1, DRD1, EGFR, GRM5, IGF1R, INSR, MMP2, PTAFR, PTGS2, SRC 4.49906
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.46544
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.46494
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, DRD1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TNKS 4.44083
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, DNMT1, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 4.4299
[BP] GO:0031960 response to corticosteroid AKR1C3, ALPL, BCL2, EGFR, FLT3, PTAFR, PTGS2, SRC 4.42957
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA3, AKR1C3, ALOX15, APP, AURKB, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 4.42701
[BP] GO:0044283 None AKR1B1, AKR1C3, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, HMGCR, MIF, PTAFR, PTGS1, PTGS2 4.40132
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DYRK1A, EGFR, ESR1, KIT, PPARA, SRC 4.3888
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 4.38545
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, EGFR, MMP9, SRC 4.35997
[BP] GO:0048545 response to steroid hormone AKR1C3, ALPL, BCL2, CA2, EGFR, FLT3, PTAFR, PTGS2, SRC 4.35539
[BP] GO:0043085 positive regulation of catalytic activity APP, AURKB, BCL2, DRD2, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, KIT, MIF, PTAFR, SMAD3, SRC, TEK, TERT, TNKS, XDH 4.35247
[BP] GO:0006730 one-carbon metabolic process CA12, CA2, CA4, CA7, CA9 4.34055
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 4.30866
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, MIF, PTGS1, PTGS2 4.28308
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, EGFR, PTGS2, TNKS, TNKS2 4.25518
[BP] GO:0051246 regulation of protein metabolic process ALOX15, APP, BCL2, CSNK2A1, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, PTAFR, PTGS2, SMAD3, SRC, TEK, XDH 4.23671
[BP] GO:0050793 regulation of developmental process APP, AXL, BCL2, CA2, CXCL8, CYP1B1, DRD2, EGFR, ESR1, ESRRA, ESRRB, F3, HMGCR, INSR, KDR, KIT, MIF, NUAK1, PIM1, PPARA, PTGS2, PTPRS, SMAD3, SRC, TEK, TERT, TNKS2, XDH 4.23555
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 4.22266
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD17B1, MIF, PTGS1, PTGS2 4.19391
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, DYRK1A, EGFR, HMGCR, HSPA1A, IGF1R, MET, MIF, NUAK1, PTGS2, PTPRS, TERT, XDH 4.19267
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA3, ALOX15, APP, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 4.19267
[BP] GO:2000377 regulation of reactive oxygen species metabolic process AKR1C3, BCL2, CYP1B1, EGFR, INSR, PTGS2, SMAD3, XDH 4.18702
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, F3, FLT3, FUT7, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGS2, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.16206
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, KIT, MET, MIF, PIM1, SRC, TEK 4.16019
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 4.13523
[BP] GO:0007611 None APP, DRD1, DRD2, EGFR, GRM5, HMGCR, INSR, KIT, PTGS2 4.13523
[BP] GO:0048869 cellular developmental process ACHE, AKR1C3, ALPL, APP, AXL, BCL2, CBR1, CYP1A1, DRD1, DRD2, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, HMGCR, KDR, KIT, MET, MIF, MMP2, MMP9, PTGS2, PTPRS, SMAD3, SRC, TEK, TERT 4.12619
[BP] GO:0006950 response to stress ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CA2, CA9, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, HSPA1A, KIT, MIF, MMP2, MMP9, NUAK1, PPARA, PTAFR, PTGS1, PTGS2, SMAD3, SRC, TEK, TERT 4.12562
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 4.10471
[BP] GO:1904018 positive regulation of vasculature development CXCL8, CYP1B1, F3, KDR, KIT, PTGS2, TEK, TERT 4.0897
[BP] GO:0051172 None APP, AURKB, CSNK2A1, DNMT1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, MIF, MMP12, MMP9, PPARA, PTGS2, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 4.08495
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK, TNKS 4.07941
[BP] GO:0050806 positive regulation of synaptic transmission APP, CA2, CA7, DRD1, DRD2, EGFR, PTGS2 4.0782
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, EGFR, ESR1, FABP3, GPR35, GRM1, GRM5, SMAD3 4.06437
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, PTGS2, SRC, TEK 4.03381
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC, TEK 3.99252
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA12, CA2, CA7, CA9, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTGS1, PTGS2, PTPRS, SLC1A1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 3.98189
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, DRD1, DRD2, HMGCR, KDR, SRC 3.97202
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, DNMT1, EGFR, FABP3, KDR, MMP2, PTAFR, PTGS2, SRC 3.96312
[BP] GO:0051338 regulation of transferase activity APP, AURKB, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KIT, MIF, SRC, TEK, TNKS 3.9525
[BP] GO:0051094 positive regulation of developmental process APP, AXL, BCL2, CA2, CXCL8, CYP1B1, DRD2, ESRRB, F3, HMGCR, INSR, KDR, KIT, PIM1, PTGS2, SMAD3, SRC, TEK, TERT 3.93265
[BP] GO:0040011 locomotion AXL, CXCL8, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, KIT, MET, MIF, MMP1, MMP12, MMP9, PTAFR, SRC, TEK 3.90372
[BP] GO:0044070 regulation of anion transport ABCB1, CA2, CA7, GRM5, MIF, PTAFR 3.90093
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, SRC, TEK 3.90093
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTAFR, PTGS2, SMAD3, SRC, TERT, TNKS, TNKS2 3.89886
[BP] GO:0015711 organic anion transport ABCB1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA, SLC1A1 3.82512
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.82113
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, EGFR, ESR1, HMGCR, HSD17B1 3.81834
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AKR1C3, AOX1, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.80323
[BP] GO:0051726 regulation of cell cycle APP, AURKB, BCL2, CSNK2A1, CXCL8, CYP1A1, DRD2, DUSP3, EGFR, HSPA1A, INSR, MIF, PIM1, PTGS2, SMAD3, SRC, TERT, TNKS 3.79862
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.79642
[BP] GO:0043269 regulation of ion transport ABCB1, APP, BCL2, CA2, CA7, DRD1, DRD2, GPR35, GRM5, MIF, MMP9, PTAFR, PTGS2 3.79614
[BP] GO:0008542 None APP, DRD1, DRD2, HMGCR, KIT 3.78686
[BP] GO:0043405 regulation of MAP kinase activity DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, KIT, MIF, SRC 3.7822
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SMAD3, SRC, TERT, TNKS 3.74974
[BP] GO:0016477 cell migration AXL, CXCL8, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, KIT, MIF, MMP1, MMP12, MMP9, SRC, TEK 3.69351
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process AKR1C3, EGFR, INSR, PTGS2, SMAD3, XDH 3.69351
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GRM5, IGF1R, INSR, PPARA, PTGS2, SRC, TEK 3.69243
[BP] GO:0050890 None APP, DRD1, DRD2, EGFR, GRM5, HMGCR, INSR, KIT, PTGS2 3.68311
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.6662
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.6662
[BP] GO:0051128 regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, DNMT1, DRD2, EGFR, ESR1, ESR2, GRIK5, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 3.6535
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 3.64451
[BP] GO:0032845 None BCL2, DRD2, HMGCR, MIF, SRC, TNKS, TNKS2 3.63699
[BP] GO:0010676 None ESRRB, INSR, PPARA, PTAFR, SRC 3.63622
[BP] GO:0043549 regulation of kinase activity APP, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KIT, MIF, SRC, TEK 3.62134
[BP] GO:0032102 negative regulation of response to external stimulus CYP19A1, DRD1, DRD2, HMGCR, MIF, PPARA, PTPRS, SMAD3, TEK 3.60736
[BP] GO:0032103 positive regulation of response to external stimulus CXCL8, EGFR, F3, FABP4, KDR, MET, MIF, PTGS2, SMAD3 3.60736
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CA9, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTGS1, PTGS2, PTPRS, SLC1A1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 3.60557
[BP] GO:0007632 None APP, DRD1, DRD2, HMGCR, KIT 3.60258
[BP] GO:0007610 None APP, BCL2, DRD1, DRD2, EGFR, GRM1, GRM5, HMGCR, INSR, KIT, PPARA, PTGS2 3.59786
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTGS2, SRC 3.58173
[BP] GO:2000026 regulation of multicellular organismal development APP, AXL, BCL2, CA2, CXCL8, CYP1B1, DRD2, EGFR, ESR1, ESRRA, F3, HMGCR, INSR, KDR, KIT, PIM1, PTGS2, PTPRS, SMAD3, SRC, TEK, TERT, XDH 3.58173
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, EGFR, KDR, PTAFR, PTGS2, SRC 3.58173
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, EGFR, ESR1, GPR35, GRM1, GRM5, SMAD3 3.58173
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PIM1, PPARA, PTGS1, PTGS2 3.5766
[BP] GO:0019216 regulation of lipid metabolic process AKR1C3, CYP1A1, FABP3, FLT3, HMGCR, KIT, PPARA, PTGS2, SRC, TEK 3.57218
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD1, DRD2, EGFR, HMGCR, KIT, PTGS2 3.55128
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, DNMT1, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 3.55128
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A1, DRD1, EGFR, ESR1, ESRRB, INSR, KIT, MMP2, MMP9, PTAFR, PTGS2, SRC 3.55128
[BP] GO:0050927 None CXCL8, F3, KDR, SMAD3 3.55128
[BP] GO:0048169 None APP, DRD2, GRM5, KIT 3.55128
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, MET, MMP12, PPARA, PTAFR, PTGS2, SMAD3, SRC, TERT, TNKS, TNKS2 3.50994
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.50526
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.50526
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.50526
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CYP1A1, DRD2, DUSP3, EGFR, INSR, MIF, SRC, TERT 3.50486
[BP] GO:0050926 None CXCL8, F3, KDR, SMAD3 3.49343
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.49343
[BP] GO:0006693 None AKR1C3, MIF, PTGS1, PTGS2 3.49343
[BP] GO:0006692 None AKR1C3, MIF, PTGS1, PTGS2 3.49343
[BP] GO:0045766 positive regulation of angiogenesis CXCL8, CYP1B1, F3, KDR, PTGS2, TEK, TERT 3.48936
[BP] GO:0003018 None DRD1, EGFR, HMGCR, PTAFR, PTGS2, SRC, TEK 3.47223
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA3, ALOX15, APP, AURKB, BCL2, CA9, CSNK2A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTGS2, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 3.42101
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.42017
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.41311
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CXCL8, CYP1B1, DNMT1, DRD1, DRD2, EGFR, GRM5, IGF1R, INSR, KDR, KIT, MET, MIF, NUAK1, PTAFR, SRC, TEK 3.41311
[BP] GO:0002682 regulation of immune system process ALOX15, APP, AXL, BCL2, CA2, CXCL8, CYP19A1, DRD2, DUSP3, ESR1, ESRRA, HSPA1A, KIT, MIF, MMP12, MMP2, PTAFR, PTPRS, SMAD3, SRC 3.41026
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, SMAD3, SRC, TEK 3.39244
[BP] GO:0022898 None ABCB1, APP, BCL2, DRD2, GPR35, GRM5, MMP9, PTAFR 3.36649
[BP] GO:0031347 regulation of defense response CYP19A1, DRD2, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTGS2, PTPRS, SMAD3, SRC, TEK 3.36472
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, AKR1C3, ALOX15, CYP19A1, CYP3A4, HMGCR, PTAFR 3.36371
[BP] GO:0010359 None ABCB1, GRM5, PTAFR 3.36323
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.36323
[BP] GO:0045859 regulation of protein kinase activity APP, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KIT, MIF, SRC 3.36052
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, CYP3A4, HSD17B1 3.36052
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, MIF, PTGS1, PTGS2 3.32883
[BP] GO:0008406 gonad development AKR1C3, BCL2, CYP19A1, ESR1, INSR, KIT 3.32183
[BP] GO:0048870 cell motility AXL, CXCL8, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, KIT, MIF, MMP1, MMP12, MMP9, SRC, TEK 3.28742
[BP] GO:1901661 None AKR1B1, AKR1B10, AKR1C3, HMGCR 3.27347
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 3.27347
[BP] GO:0042391 None APP, BCL2, DRD1, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 3.26246
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, DNMT1, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MET, MMP12, PPARA, SMAD3, SRC, TERT, TNKS, TNKS2 3.22614
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.22582
[BP] GO:0071276 cellular response to cadmium ion AKR1C3, CYP1A2, EGFR, MMP9 3.22018
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, ALPL, AXL, BCL2, CYP19A1, EGFR, ESR1, ESRRB, INSR, KIT, PTGS2, SRC 3.21057
[BP] GO:0032409 None ABCB1, APP, BCL2, DRD2, GPR35, GRM5, MMP9, PTAFR 3.2057
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, PTGS1 3.1998
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 3.17277
[BP] GO:0050794 regulation of cellular process ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CA9, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTGS1, PTGS2, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 3.1617
[BP] GO:0045913 None ESRRB, INSR, PPARA, PTAFR, SRC 3.15099
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PIM1, PPARA, PTGS1, PTGS2 3.13547
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1, HMGCR 3.1257
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC, TEK 3.1257
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.1257
[BP] GO:0010863 positive regulation of phospholipase C activity EGFR, ESR1, KIT, PTAFR 3.1257
[BP] GO:0072507 divalent inorganic cation homeostasis APP, BCL2, DRD1, DRD2, EGFR, ESR1, GPR35, GRM1, GRM5, SMAD3 3.11825
[BP] GO:0009889 regulation of biosynthetic process ADORA3, AKR1C3, APP, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DNMT1, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, PIM1, PPARA, PTAFR, PTGS2, SMAD3, SRC, TERT, TNKS, TNKS2 3.11592
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.11201
[BP] GO:1901342 regulation of vasculature development CXCL8, CYP1B1, F3, KDR, KIT, PTGS2, TEK, TERT, XDH 3.11201
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, CXCL8, EGFR, FLT3, FUT7, HSPA1A, KIT, MIF, MMP9, PTAFR, SMAD3, SRC 3.08893
[BP] GO:0050920 regulation of chemotaxis CXCL8, CYP19A1, F3, KDR, MET, MIF, SMAD3 3.08221
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, AKR1C3, CSNK2A1, DRD1, DRD2 3.08221
[BP] GO:0008306 None APP, DRD1, DRD2, HMGCR, KIT 3.07772
[BP] GO:0006082 organic acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PIM1, PPARA, PTGS1, PTGS2 3.06197
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC, TEK 3.05038
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR 3.03744
[BP] GO:0055080 cation homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, EGFR, ESR1, GPR35, GRM1, GRM5, SMAD3 3.03744
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 3.00196
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 3.00196
[BP] GO:1900274 regulation of phospholipase C activity EGFR, ESR1, KIT, PTAFR 2.99154
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CYP19A1, CYP3A4, HMGCR, HSD17B1 2.98503
[BP] GO:0016488 None AKR1B10, AKR1C3 2.97034
[BP] GO:0016487 None AKR1B10, AKR1C3 2.97034
[BP] GO:0016107 None AKR1B10, AKR1C3 2.97034
[BP] GO:0009115 None AOX1, XDH 2.97034
[BP] GO:0006714 None AKR1B10, AKR1C3 2.97034
[BP] GO:0034762 None ABCB1, APP, BCL2, CA2, DRD1, DRD2, GPR35, GRM5, MMP9, PTAFR 2.96867
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AURKB, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTAFR, SMAD3, SRC, TERT, TNKS, TNKS2 2.96053
[BP] GO:0007154 None AKR1C3, AXL, BCL2, DRD1, DRD2, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PTGS2, SLC1A1, TEK 2.96053
[BP] GO:0007193 None DRD2, GRM1, GRM3, GRM5, GRM8 2.96053
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CXCL8, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, KIT, MIF, MMP1, MMP12, MMP9, PTGS2, SRC, TEK, TUBB3 2.94958
[BP] GO:0003008 None AKR1B1, AKR1C3, APP, BCL2, CYP1B1, DRD1, DRD2, EGFR, GRM1, GRM5, GRM8, HMGCR, INSR, KIT, PTAFR, PTGS2, SRC, TEK 2.93928
[BP] GO:0071229 cellular response to acid chemical AKR1C3, DNMT1, EGFR, KDR, MMP2, PTAFR, SRC 2.93619
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PTGS2, SMAD3, SRC, TERT 2.9325
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.9325
[BP] GO:0048608 reproductive structure development AKR1C3, AXL, BCL2, CYP19A1, ESR1, INSR, KIT, SRC 2.92476
[BP] GO:0016042 lipid catabolic process AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.92476
[BP] GO:0006820 anion transport ABCB1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA, SLC1A1 2.92476
[BP] GO:0001516 None MIF, PTGS1, PTGS2 2.92207
[BP] GO:0046457 None MIF, PTGS1, PTGS2 2.92207
[BP] GO:0040008 regulation of growth APP, BCL2, CSNK2A1, DRD2, EGFR, ESR2, HSPA1A, INSR, PIM1, PTPRS, SMAD3, TNKS2 2.90742
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, ESR1, GPR35, GRIK5, GRM1, GRM5, SMAD3 2.90742
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, BCL2, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT, TNKS 2.87015
[BP] GO:0070542 None AKR1C3, FABP3, PTAFR, PTGS2, SRC 2.87015
[BP] GO:1901570 None ALOX15, ALOX5, MIF, PTGS1, PTGS2 2.87015
[BP] GO:0006066 None AKR1B1, AKR1B10, AKR1C3, APP, CYP1B1, CYP3A4, HMGCR, PTAFR 2.86585
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.82649
[BP] GO:0030155 regulation of cell adhesion ALOX15, BCL2, CXCL8, CYP1B1, DUSP3, KDR, NUAK1, PPARA, PTAFR, SMAD3, SRC, TEK 2.81106
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.80591
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.80591
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.80469
[BP] GO:0003013 None DRD1, EGFR, HMGCR, PTAFR, PTGS2, SRC, TEK 2.80363
[BP] GO:0001816 cytokine production APP, FABP4, KIT, PTAFR, PTGS2 2.80134
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.79337
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, PTAFR, PTGS2 2.79137
[BP] GO:0030003 cellular cation homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, ESR1, GPR35, GRM1, GRM5, SMAD3 2.78803
[BP] GO:0045934 None AURKB, DNMT1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HSPA1A, MMP12, PPARA, SMAD3, SRC, TERT, TNKS, TNKS2 2.78748
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, DRD1, DRD2, KDR, SRC 2.77087
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.74613
[BP] GO:0044259 multicellular organismal macromolecule metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.7369
[BP] GO:0043551 regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 2.7369
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTGS2, SRC, TERT 2.73651
[BP] GO:0051347 positive regulation of transferase activity AURKB, DRD2, EGFR, FLT3, GRM1, GRM5, INSR, KIT, MIF, SRC, TEK, TNKS 2.73106
[BP] GO:0007268 None DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.71639
[BP] GO:0098916 None DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.71639
[BP] GO:0006874 cellular calcium ion homeostasis APP, BCL2, DRD1, DRD2, ESR1, GPR35, GRM1, GRM5, SMAD3 2.70901
[BP] GO:0006873 cellular ion homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, ESR1, GPR35, GRM1, GRM5, SMAD3 2.7074
[BP] GO:0010605 negative regulation of macromolecule metabolic process APP, AURKB, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, HMGCR, HSPA1A, IGF1R, KDR, MIF, MMP12, MMP9, PPARA, PTGS2, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 2.68028
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.6761
[BP] GO:0070920 None EGFR, ESR1, TERT 2.6761
[BP] GO:0032225 None DRD1, DRD2, PTGS2 2.6761
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.6761
[BP] GO:0099536 None DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.65598
[BP] GO:0099537 None DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.65598
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, KIT, MET, MMP1, SMAD3, SRC, TEK 2.65424
[BP] GO:0008217 None DRD2, PPARA, PTAFR, PTGS1, PTGS2, SMAD3 2.65015
[BP] GO:0008285 negative regulation of cell proliferation ADORA3, APP, BCL2, CXCL8, CYP1B1, DRD2, FABP3, HSPA1A, PTGS2, SMAD3, TERT, XDH 2.63999
[BP] GO:0055074 calcium ion homeostasis APP, BCL2, DRD1, DRD2, ESR1, GPR35, GRM1, GRM5, SMAD3 2.62113
[BP] GO:0008584 None AKR1C3, BCL2, ESR1, INSR, KIT 2.62113
[BP] GO:0032412 None ABCB1, APP, DRD2, GPR35, GRM5, MMP9, PTAFR 2.62097
[BP] GO:0001819 positive regulation of cytokine production CYP1B1, DRD2, HSPA1A, MIF, MMP12, PTAFR, PTGS2, SMAD3, SRC 2.60695
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.60422
[BP] GO:0072503 cellular divalent inorganic cation homeostasis APP, BCL2, DRD1, DRD2, ESR1, GPR35, GRM1, GRM5, SMAD3 2.58358
[BP] GO:0048167 None APP, DRD1, DRD2, GRM5, KIT, PTGS2 2.57911
[BP] GO:0099566 None GRM1, GRM5 2.57439
[BP] GO:0046110 None AOX1, XDH 2.57439
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.57439
[BP] GO:0016095 None AKR1B10, AKR1C3 2.57439
[BP] GO:0010564 regulation of cell cycle process APP, AURKB, BCL2, CSNK2A1, CYP1A1, DRD2, EGFR, HSPA1A, INSR, MIF, TERT, TNKS 2.56282
[BP] GO:0043065 positive regulation of apoptotic process AKR1C3, BCL2, CYP1B1, F3, GRIK5, HMGCR, MMP9, PTGS2, SMAD3, SRC, XDH 2.55927
[BP] GO:0007188 None DRD1, DRD2, GRM1, GRM3, GRM5, GRM8 2.55866
[BP] GO:2000351 None AKR1C3, KDR, TEK, TERT 2.55313
[BP] GO:0010518 positive regulation of phospholipase activity EGFR, ESR1, KIT, PTAFR 2.55313
[BP] GO:0071900 regulation of protein serine/threonine kinase activity DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, KIT, MIF, SRC 2.55283
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, EGFR, FABP3, FABP4, KIT, MET 2.54915
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3 2.54396
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTGS2, SRC 2.53629
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, KDR, KIT, TEK 2.53629
[BP] GO:0016101 None AKR1B10, AKR1C3, CYP1A1, CYP1B1, EGFR 2.53629
[BP] GO:0050730 None APP, EGFR, FLT3, GRM5, KIT, MIF, SRC 2.53629
[BP] GO:0007568 aging AURKB, BCL2, CYP1A1, HMGCR, MIF, PTGS2, TERT 2.53629
[BP] GO:0043068 positive regulation of programmed cell death AKR1C3, BCL2, CYP1B1, F3, GRIK5, HMGCR, MMP9, PTGS2, SMAD3, SRC, XDH 2.53247
[BP] GO:1900542 None DRD1, DRD2, ESRRB, GRM3, GRM8, INSR, PPARA 2.50292
[BP] GO:0001817 regulation of cytokine production AXL, CYP1B1, DRD2, HSPA1A, MIF, MMP12, PTAFR, PTGS2, PTPRS, SMAD3, SRC 2.50282
[BP] GO:0033138 positive regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, MIF, PTGS2 2.49773
[BP] GO:0048168 None APP, DRD2, GRM5, KIT 2.49662
[BP] GO:0031326 regulation of cellular biosynthetic process ADORA3, AKR1C3, APP, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DNMT1, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KIT, MET, MMP12, PIM1, PPARA, PTAFR, PTGS2, SMAD3, SRC, TERT, TNKS, TNKS2 2.49529
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.48479
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.48479
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, DRD2, EGFR, MIF, MMP12, PTGS2, SMAD3, SRC 2.48455
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.47254
[BP] GO:0043550 regulation of lipid kinase activity FLT3, KIT, SRC, TEK 2.47254
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.47017
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.47017
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.47017
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.47017
[BP] GO:0044057 None ADORA3, DRD2, EGFR, GPR35, GRM1, KIT, PTAFR, PTGS2, SLC1A1, SMAD3 2.46582
[BP] GO:0010628 positive regulation of gene expression APP, DNMT1, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, INSR, KIT, MET, MMP12, PPARA, PTAFR, SMAD3, SRC, TERT, TNKS 2.4641
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DRD1, DYRK1A, SRC, TNKS 2.45521
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.45521
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.44984
[BP] GO:0006140 None DRD1, DRD2, ESRRB, GRM3, GRM8, INSR, PPARA 2.44554
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AURKB, AXL, BACE1, BCL2, CSNK2A1, DRD1, DUSP3, DYRK1A, EGFR, ESR1, F3, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 2.44244
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, SMAD3, SRC, TEK 2.43952
[BP] GO:0009314 response to radiation APP, AURKB, BCL2, DRD1, DRD2, EGFR, HMGCR, KIT, PTGS2 2.43828
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.43429
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.42582
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.42582
[BP] GO:0071363 cellular response to growth factor stimulus APP, CXCL8, EGFR, INSR, KDR, SMAD3, SRC 2.40881
[BP] GO:0048565 None CXCL8, CYP1A1, EGFR, KIT 2.3962
[BP] GO:0044236 multicellular organism metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.38824
[BP] GO:0031348 negative regulation of defense response CYP19A1, DRD2, MMP12, PPARA, SMAD3, TEK 2.38374
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.37949
[BP] GO:1903959 None ABCB1, GRM5, PTAFR 2.37949
[BP] GO:0051968 None DRD1, EGFR, PTGS2 2.37949
[BP] GO:0009991 response to extracellular stimulus AKR1C3, ALPL, AXL, BCL2, CYP1A1, EGFR, HMGCR, PTGS2, SRC 2.37229
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.35584
[BP] GO:0006954 inflammatory response ADORA3, ALOX15, AXL, CXCL8, KIT, MIF, PTAFR, PTGS1, PTGS2 2.35209
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.34563
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.34563
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA3, AKR1C3, APP, CA2, CXCL8, DRD1, DRD2, ESR1, GPR35, GRM1, GRM3, GRM5, GRM8, INSR, PTAFR, SRC 2.34282
[BP] GO:0035295 tube development AKR1B1, CXCL8, CYP1A1, EGFR, KIT, SMAD3 2.34041
[BP] GO:0070213 None TNKS, TNKS2 2.34041
[BP] GO:0006145 None AOX1, XDH 2.34041
[BP] GO:1901529 None ABCB1, PTAFR 2.34041
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.34041
[BP] GO:0022603 regulation of anatomical structure morphogenesis BCL2, CXCL8, CYP1B1, ESR1, F3, KDR, KIT, PIM1, PTGS2, PTPRS, SRC, TEK, TERT, XDH 2.33574
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.33414
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.33414
[BP] GO:0050776 regulation of immune response ALOX15, BCL2, DRD2, DUSP3, ESR1, HSPA1A, KIT, MIF, MMP12, MMP2, PTAFR, PTPRS, SMAD3, SRC 2.3293
[BP] GO:0055065 metal ion homeostasis APP, BCL2, DRD1, DRD2, EGFR, ESR1, GPR35, GRM1, GRM5, SMAD3 2.32896
[BP] GO:0033674 positive regulation of kinase activity DRD2, EGFR, FLT3, GRM1, GRM5, INSR, KIT, MIF, SRC, TEK 2.31255
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, PTAFR, SRC 2.31255
[BP] GO:0010517 regulation of phospholipase activity EGFR, ESR1, KIT, PTAFR 2.30535
[BP] GO:0010942 positive regulation of cell death AKR1C3, BCL2, CYP1B1, F3, GRIK5, HMGCR, MMP9, PTGS2, SMAD3, SRC, XDH 2.30462
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AXL, CYP1A1, DRD1, EGFR, ESR1, KIT, PTGS2, SRC 2.30308
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.28384
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.28091
[BP] GO:0019725 cellular homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, ESR1, GPR35, GRIK5, GRM1, GRM5, SMAD3 2.27199
[BP] GO:0050900 leukocyte migration CXCL8, FUT7, KIT, MIF, MMP1, MMP9, SRC, TEK 2.27199
[BP] GO:0007187 None DRD1, DRD2, GRM1, GRM3, GRM5, GRM8 2.2565
[BP] GO:0051179 None ABCB1, ACHE, AKR1C3, ALOX15, ALOX5, APP, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CA9, CXCL8, DRD1, DRD2, EGFR, ESR1, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, KIT, MIF, MMP12, MMP9, PPARA, PTAFR, SLC1A1, SRC, TERT, TNKS, TNKS2, XDH 2.24758
[BP] GO:0043406 positive regulation of MAP kinase activity EGFR, FLT3, GRM1, INSR, KIT, MIF, SRC 2.24758
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DRD1, DYRK1A, SRC, TNKS 2.24758
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.24383
[BP] GO:0051894 None KDR, SMAD3, TEK 2.24083
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.24083
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.24083
[BP] GO:1903532 None ACHE, CYP19A1, DRD2, EGFR, MIF, MMP12, PTAFR, SRC 2.24021
[BP] GO:0071396 cellular response to lipid AKR1C3, AXL, CXCL8, EGFR, ESR1, FLT3, PTAFR, SRC 2.24021
[BP] GO:0060193 positive regulation of lipase activity EGFR, ESR1, KIT, PTAFR 2.23966
[BP] GO:0051336 regulation of hydrolase activity APP, CSNK2A1, DRD2, EGFR, ESR1, F3, HSPA1A, KIT, MMP9, NUAK1, PTAFR, PTGS2, SMAD3, SRC, XDH 2.22589
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, KDR, SMAD3, SRC, TEK 2.20692
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, DRD1, DRD2, PTGS2 2.19144
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.19144
[BP] GO:0010675 None ESRRB, INSR, PPARA, PTAFR, SRC 2.16996
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.16836
[BP] GO:0051926 negative regulation of calcium ion transport BCL2, DRD2, GPR35, PTGS2 2.16836
[BP] GO:0021853 None DRD1, DRD2 2.1621
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1 2.1621
[BP] GO:0010641 None F3, SRC 2.1621
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.1621
[BP] GO:1904936 None DRD1, DRD2 2.1621
[BP] GO:0033043 regulation of organelle organization ALOX15, AURKB, BCL2, DNMT1, GRIK5, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 2.1621
[BP] GO:0007584 response to nutrient AKR1C3, ALPL, CYP1A1, EGFR, HMGCR, PTGS2 2.15803
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.15783
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.15783
[BP] GO:1903393 None KDR, SMAD3, TEK 2.15783
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling FLT3, KDR, KIT, TEK 2.15552
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CXCL8, CYP1A1, CYP1A2, PTGS2, SRC 2.14933
[BP] GO:0097746 None DRD1, EGFR, HMGCR, PTAFR, PTGS2 2.13767
[BP] GO:0035296 None DRD1, EGFR, HMGCR, PTAFR, PTGS2 2.13767
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, PTGS2 2.13767
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, DRD2, TNKS2 2.13392
[BP] GO:0070848 response to growth factor APP, CXCL8, EGFR, INSR, KDR, SMAD3, SRC 2.13392
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.11618
[BP] GO:1904646 cellular response to amyloid-beta APP, GRM5, IGF1R 2.11618
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, DRD2, EGFR, MIF, MMP12, PTGS2, SMAD3, SRC 2.0953
[BP] GO:0051480 regulation of cytosolic calcium ion concentration DRD1, DRD2, ESR1, GPR35, GRM1, GRM5, SMAD3 2.0841
[BP] GO:0048568 None CXCL8, EGFR, ESRRB, KDR, KIT 2.08224
[BP] GO:2001233 regulation of apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTGS2, SMAD3, SRC, TERT 2.07487
[BP] GO:0051482 None DRD1, GPR35, GRM1 2.07487
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.07487
[BP] GO:0033554 cellular response to stress AKR1B1, AKR1C3, ALOX15, AXL, BCL2, CA2, CA9, CXCL8, CYP1B1, EGFR, HSPA1A, MIF, MMP9, NUAK1, PTGS2, SRC, TERT 2.07486
[BP] GO:0006875 cellular metal ion homeostasis APP, BCL2, DRD1, DRD2, ESR1, GPR35, GRM1, GRM5, SMAD3 2.07376
[BP] GO:0007416 None ACHE, APP, DRD1, DRD2 2.07354
[BP] GO:1903524 None EGFR, PTAFR, PTGS2, SLC1A1 2.07354
[BP] GO:0050921 positive regulation of chemotaxis CXCL8, F3, KDR, MET, SMAD3 2.07354
[BP] GO:0051047 None ACHE, CYP19A1, DRD2, EGFR, MIF, MMP12, PTAFR, SRC 2.07354
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AURKB, AXL, BACE1, BCL2, CSNK2A1, DRD1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP2, NUAK1, PIM1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 2.07354
[BP] GO:0051234 None ABCB1, ACHE, AKR1C3, ALOX15, ALOX5, APP, AXL, CA12, CA14, CA2, CA4, CA7, CA9, CXCL8, DRD1, DRD2, EGFR, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, KIT, MIF, MMP12, MMP9, PPARA, PTAFR, SLC1A1, SRC, TERT, TNKS, XDH 2.07068
[BP] GO:0045321 leukocyte activation ALOX5, AXL, BCL2, CXCL8, FLT3, FUT7, HSPA1A, KIT, MIF, MMP9, PTAFR, SMAD3 2.05637
[BP] GO:1900543 None DRD2, GRM3, GRM8, PPARA 2.05614
[BP] GO:0033135 regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, MIF, PTGS2 2.0477
[BP] GO:0045980 None DRD2, GRM3, GRM8, PPARA 2.0366
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, CYP1B1, ESR1, ESR2, HSPA1A, KIT, PIM1 2.0366
[BP] GO:0051052 regulation of DNA metabolic process AURKB, DNMT1, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 2.0366
[BP] GO:0050727 regulation of inflammatory response CYP19A1, EGFR, ESR1, FABP4, PPARA, PTGS2, SMAD3, TEK 2.0366
[BP] GO:0050880 None DRD1, EGFR, HMGCR, PTAFR, PTGS2 2.0366
[BP] GO:0010760 negative regulation of macrophage chemotaxis CYP19A1, MIF 2.03251
[BP] GO:0021843 None DRD1, DRD2 2.03251
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.03251
[BP] GO:0046113 None AOX1, XDH 2.03251
[BP] GO:1990535 None APP, INSR 2.03251
[BP] GO:0021830 None DRD1, DRD2 2.03251
[BP] GO:1903961 None ABCB1, PTAFR 2.03251
[BP] GO:1904306 None KIT, PTAFR 2.03251
[BP] GO:1904304 None KIT, PTAFR 2.03251
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.03251
[BP] GO:0021826 None DRD1, DRD2 2.03251
[BP] GO:2001300 lipoxin metabolic process ALOX15, ALOX5 2.03251
[BP] GO:0016115 None AKR1B10, AKR1C3 2.03251
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP3A4 2.03251
[BP] GO:0035150 None DRD1, EGFR, HMGCR, PTAFR, PTGS2 2.03248
[BP] GO:1901653 cellular response to peptide AKR1B1, APP, GRM5, IGF1R, INSR, SRC 2.02715
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.02703
[BP] GO:0051248 None APP, CSNK2A1, DNMT1, DUSP3, EGFR, FABP4, HMGCR, HSPA1A, IGF1R, MIF, MMP9, PTGS2, SMAD3, SRC, XDH 2.0151
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CXCL8, CYP1A1, CYP1A2, PTGS2, SRC 2.0151
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.01444
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.01444
[BP] GO:1904645 response to amyloid-beta APP, GRM5, IGF1R 2.01444
[BP] GO:1901575 None ACHE, AKR1B10, AKR1C3, AOX1, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, HSPA1A, XDH 2.01182
[BP] GO:0045765 regulation of angiogenesis CXCL8, CYP1B1, F3, KDR, PTGS2, TEK, TERT 2.00973
[BP] GO:0071383 None AKR1C3, EGFR, FLT3, SRC 2.00973
[CC] GO:0044459 plasma membrane part ABCB1, ADORA3, ALOX15, APP, AXL, BACE1, CA2, CA4, CA9, DRD1, DRD2, DUSP3, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, KIT, MET, PTAFR, PTGS2, PTPRS, SLC1A1, SRC, TEK 6.64361
[CC] GO:0098590 plasma membrane region ABCB1, CA2, CA4, CA9, DRD1, DRD2, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, MET, PTGS2, SLC1A1, SRC, TEK 6.11293
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, APP, AXL, BACE1, CA4, DRD1, DRD2, F3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PTAFR, PTPRS, SLC1A1, TEK 5.30389
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA3, ALOX15, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, EGFR, ESR1, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, KIT, MET, MMP2, PIM1, PTAFR, PTPRS, SLC1A1, SMAD3, SRC, TEK, TERT 5.25541
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA3, ALOX15, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, EGFR, ESR1, F3, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, INSR, KDR, KIT, MET, MMP2, PIM1, PTAFR, PTGS1, PTGS2, PTPRS, SLC1A1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2 4.59938
[CC] GO:0005887 integral component of plasma membrane ADORA3, APP, AXL, BACE1, DRD1, DRD2, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PTAFR, PTPRS, SLC1A1, TEK 4.42076
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, AKR1B1, AKR1B10, AKR1C3, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA4, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GRIA4, GRIK5, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPRS, SLC1A1, SMAD3, SRC, TERT, TNKS, TNKS2, TUBB3, XDH 3.90184
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA3, ALOX15, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, INSR, KDR, KIT, MET, PTAFR, PTGS1, PTGS2, PTPRS, SLC1A1, SRC, TEK 3.74586
[CC] GO:0043226 organelle ABCB1, ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA4, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GRIA4, GRIK5, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, KIT, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPRS, SLC1A1, SMAD3, SRC, TERT, TNKS, TNKS2, TUBB3, XDH 3.55405
[CC] GO:0043005 None APP, BACE1, CA2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, PTPRS, SRC, TUBB3 3.33819
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.32883
[CC] GO:0043235 receptor complex APP, EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, SMAD3 3.19015
[CC] GO:0044421 None ABCB1, ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APP, AXL, CA2, CA4, CBR1, CXCL8, DUSP3, EGFR, ESRRA, F3, FABP3, FABP4, GRIA4, GRM5, HSPA1A, INSR, KIT, MIF, MMP1, MMP12, MMP2, MMP9, PTGS1, PTPRS, SLC1A1, SRC, TUBB3, XDH 3.14281
[CC] GO:0009986 cell surface ABCB1, ACHE, APP, AXL, BACE1, CA4, EGFR, F3, MET, MIF, TEK 2.93928
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, EGFR, FLT3, GRIA2, HMGCR, PTGS1, PTGS2 2.79337
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, EGFR, GRIA2, HMGCR, PTGS1, PTGS2 2.73315
[CC] GO:0120025 None AKR1B1, APP, BACE1, CA2, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, PTPRS, SRC, TEK, TUBB3 2.73106
[CC] GO:0045121 membrane raft APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.70795
[CC] GO:0098857 membrane microdomain APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.68911
[CC] GO:0044456 None ACHE, APP, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PTPRS, SRC 2.67883
[CC] GO:0031090 None ALOX5, APP, BACE1, BCL2, CA4, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, EGFR, FUT7, GRIA2, GRIA4, HMGCR, INSR, PTAFR, PTGS1, PTGS2, SMAD3, SRC, TNKS, TNKS2 2.62476
[CC] GO:0042995 cell projection AKR1B1, APP, BACE1, CA2, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, PTPRS, SRC, TEK, TUBB3 2.48198
[CC] GO:0097458 None APP, BACE1, CA2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, PTGS1, PTGS2, PTPRS, SRC, TUBB3 2.43972
[CC] GO:0044464 cell part ABCB1, ACHE, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, DRD1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTGS1, PTGS2, PTPRS, SLC1A1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TUBB3, XDH 2.39356
[CC] GO:1903561 None ABCB1, AKR1B1, AKR1B10, AKR1C3, ALPL, AOX1, APP, AXL, CA2, CA4, CBR1, DUSP3, F3, FABP3, FABP4, GRIA4, GRM5, HSPA1A, INSR, MIF, MMP9, PTGS1, PTPRS, SLC1A1, SRC, TUBB3 2.3148
[CC] GO:0043230 None ABCB1, AKR1B1, AKR1B10, AKR1C3, ALPL, AOX1, APP, AXL, CA2, CA4, CBR1, DUSP3, F3, FABP3, FABP4, GRIA4, GRM5, HSPA1A, INSR, MIF, MMP9, PTGS1, PTPRS, SLC1A1, SRC, TUBB3 2.31417
[CC] GO:0030424 None APP, BACE1, CA2, DRD2, GRM3, PTPRS, TUBB3 2.30844
[CC] GO:0031982 None ABCB1, AKR1B1, AKR1B10, AKR1C3, ALPL, AOX1, APP, AXL, BACE1, CA2, CA4, CBR1, DRD2, DUSP3, EGFR, F3, FABP3, FABP4, GRIA4, GRM5, HSPA1A, INSR, KDR, KIT, MIF, MMP9, PTGS1, PTPRS, SLC1A1, SRC, TUBB3 2.27199
[CC] GO:0098589 membrane region APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.24824
[CC] GO:0043197 None APP, DRD2, GRIA2, GRIA4, GRM3 2.21639
[CC] GO:0044309 None APP, DRD2, GRIA2, GRIA4, GRM3 2.18606
[CC] GO:0014069 None DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 2.11129
[CC] GO:0099572 None DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 2.11129
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 2.07354
[CC] GO:0070062 None ABCB1, AKR1B1, AKR1B10, AKR1C3, ALPL, AOX1, APP, AXL, CA2, CA4, CBR1, DUSP3, F3, FABP3, FABP4, GRM5, HSPA1A, INSR, MIF, MMP9, PTGS1, PTPRS, SLC1A1, SRC, TUBB3 2.05875
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTAFR, PTGS1, PTGS2, PTPRS, SLC1A1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TUBB3, XDH 12.9853
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, APP, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SMAD3, TNKS, XDH 12.9853
[MF] GO:0003824 catalytic activity ABCB1, ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, DUSP3, DYRK1A, EGFR, F3, FLT3, FUT7, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGS1, PTGS2, PTPRS, SRC, TEK, TERT, TNKS, TNKS2, TUBB3, XDH 10.3618
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 8.57374
[MF] GO:0038023 signaling receptor activity ADORA3, AXL, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, KIT, MET, PPARA, PTAFR, TEK 8.40498
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 8.26473
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.15624
[MF] GO:0004089 carbonate dehydratase activity CA12, CA14, CA2, CA4, CA7, CA9 8.01287
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 7.74195
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH 7.54292
[MF] GO:0004872 receptor activity ADORA3, AXL, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, KIT, MET, PPARA, PTAFR, TEK 7.38384
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PTGS1, PTGS2, SRC 7.28743
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD17B1, PTGS1, PTGS2, XDH 7.26892
[MF] GO:0004871 signal transducer activity ADORA3, AXL, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, KIT, MET, PPARA, PTAFR, SMAD3, TEK 7.20469
[MF] GO:0060089 molecular transducer activity ADORA3, AXL, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, KIT, MET, PPARA, PTAFR, TEK 7.13295
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 7.09093
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PTGS1, PTGS2, SRC 7.02179
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 6.93733
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PTGS1, PTGS2 6.59927
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, DRD1, DRD2, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PPARA, SRC, TEK 6.52972
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, KIT, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGS1, PTGS2, SLC1A1, SMAD3, TERT, TNKS, TNKS2, XDH 6.2233
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 5.8831
[MF] GO:0099600 transmembrane receptor activity ADORA3, AXL, DRD1, DRD2, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, KIT, MET, PTAFR, TEK 5.78425
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, AXL, DRD1, DRD2, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, KIT, MET, PTAFR, TEK 5.78425
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD17B1, PTGS1, PTGS2, SRC, XDH 5.56406
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 5.27193
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR, KIT 5.25541
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, ESR1, ESR2, ESRRA, ESRRB, KIT, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGS1, PTGS2, SLC1A1, SMAD3, TERT, TNKS, TNKS2, XDH 5.14897
[MF] GO:0008270 zinc ion binding CA12, CA2, CA4, CA7, CA9, DNMT1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, SMAD3, TNKS 5.14897
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 4.86376
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, AOX1, CBR1, HMGCR, HSD17B1, XDH 4.81338
[MF] GO:0016836 hydro-lyase activity CA12, CA14, CA2, CA4, CA7, CA9 4.80156
[MF] GO:0019899 enzyme binding APP, AURKB, BACE1, BCL2, CYP1A1, CYP1A2, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, GRM5, HMGCR, HSPA1A, KIT, MET, MIF, PPARA, PTAFR, PTGS2, SMAD3, SRC, TEK, TNKS2 4.59938
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, BCL2, CSNK2A1, DRD2, DYRK1A, EGFR, ESR1, ESR2, FLT3, GRIK5, HMGCR, IGF1R, KDR, KIT, MET, MIF, MMP9, PTGS2, SMAD3, TERT, XDH 4.59009
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 4.44083
[MF] GO:0030594 None DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM5 4.34084
[MF] GO:0043168 anion binding ABCB1, ALOX15, AOX1, APP, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PTAFR, PTPRS, SLC1A1, SRC, TEK, TUBB3, XDH 4.34084
[MF] GO:0016835 carbon-oxygen lyase activity CA12, CA14, CA2, CA4, CA7, CA9 4.09948
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 3.98584
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, AOX1, XDH 3.9525
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1 3.79614
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.74831
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.74831
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 3.58173
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.41311
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TERT 3.40839
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD17B1, PPARA, PTAFR 3.37997
[MF] GO:0036094 small molecule binding ABCB1, AOX1, AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SLC1A1, SRC, TEK, TUBB3, XDH 3.36371
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.36323
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, CBR1, HMGCR, HSD17B1 3.11201
[MF] GO:0000166 nucleotide binding ABCB1, AOX1, AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, EGFR, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TUBB3, XDH 2.98179
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AOX1, AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, EGFR, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TUBB3, XDH 2.97964
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.97034
[MF] GO:0045550 None AKR1B10, AKR1C3 2.97034
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.97034
[MF] GO:0008389 None CYP2A13, CYP2A6 2.97034
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 2.75883
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.57439
[MF] GO:0047718 None AKR1B10, AKR1C3 2.57439
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.57439
[MF] GO:0099583 None GRM1, GRM5 2.57439
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.48479
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.48479
[MF] GO:0097159 organic cyclic compound binding ABCB1, AOX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, PIM1, PPARA, PTGS1, PTGS2, SMAD3, SRC, TEK, TERT, TUBB3, XDH 2.47254
[MF] GO:0019902 phosphatase binding BCL2, EGFR, HMGCR, MET, PPARA, SMAD3 2.46619
[MF] GO:0044877 macromolecular complex binding ACHE, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, SMAD3, SRC 2.46308
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.43547
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.35584
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.34041
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.34041
[MF] GO:0004971 None GRIA2, GRIA4 2.34041
[MF] GO:0051425 None APP, INSR 2.34041
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.34041
[MF] GO:0001540 amyloid-beta binding ACHE, BACE1, GRIA2, INSR 2.28091
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CSNK2A1, DUSP3, DYRK1A, EGFR, F3, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPRS, SRC, TEK 2.28091
[MF] GO:0016829 lyase activity CA12, CA14, CA2, CA4, CA7, CA9 2.24758
[MF] GO:0032403 protein complex binding ACHE, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, SMAD3, SRC 2.24299
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 2.22342
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.21572
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.1621
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.1621
[MF] GO:0043559 insulin binding IGF1R, INSR 2.1621
[MF] GO:0005057 signal transducer activity, downstream of receptor EGFR, INSR, KDR, KIT, SMAD3 2.1621
[MF] GO:0004033 None AKR1B1, AKR1B10, AKR1C3 2.15783
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, PTGS2 2.15783
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 2.12651
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, PTGS2 2.11618
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 2.09682
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.06031
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.03952
[MF] GO:0043546 None AOX1, XDH 2.03251


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, CYP1A1, AKR1C3, CYP1B1, PTGS2, CYP19A1, IGF1R 10.0646
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, GRIA2, GRM5, GPR35, ADORA3, GRIK5, PTAFR, GRM8, DRD1, DRD2, GRM1, GRIA4 7.1357
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA2, CA4, CA7, CA9, CA14 8.368
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, GRM1, EGFR, ESR2, HSPA1A 6.6548
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 7.1357
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, CYP1A2, CYP1A1, AKR1C3, CYP1B1, CYP3A4, CYP19A1 6.8529
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.3914
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, CXCL8, FLT3, MMP1, MMP2, KIT, BCL2, PTGS2, MMP9, MET, EGFR, IGF1R 5.9154
Bladder cancer_Homo sapiens_hsa05219 CXCL8, SRC, MMP1, MMP2, MMP9, EGFR 6.3914
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.3914
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 6.3914
Metabolic pathways_Homo sapiens_hsa01100 CBR1, DNMT1, ALOX15, AKR1C3, AKR1B1, HMGCR, PTGS2, CYP3A4, CYP19A1, PTGS1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, CYP1A2, CYP1A1, AOX1, ALPL, XDH 5.8274
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, CXCL8, INSR, KIT, GRM8, GRM1, EGFR 5.7462
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, TUBB3, DRD1, DRD2, GRM1, EGFR 5.9154
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KIT, KDR, TEK, DRD2, MET, EGFR, IGF1R 5.6176
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, AKR1C3, PTGS2, PTGS1 5.6176
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 4.7226
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, CXCL8, MMP2, BCL2, PIM1, F3 4.4782
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, ABCB1, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR 4.4782
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KIT, KDR, MET, EGFR, IGF1R, HSPA1A 4.0313
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KIT, KDR, TEK, MET, EGFR, IGF1R 3.5071
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 4.2249
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KIT, KDR, BCL2, TEK, MET, EGFR, IGF1R 3.3003
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, PTGS2, GRM1, GRIA4 3.3866
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, BCL2, TEK, EGFR, IGF1R 3.3623
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15, PTGS2, PTGS1 3.2354
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, EGFR, IGF1R 3.0263
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, PTGS2, PTGS1 3.3003
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.782
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, DRD1, DRD2 3.4652
Hepatitis B_Homo sapiens_hsa05161 SMAD3, CXCL8, SRC, BCL2, MMP9 2.8122
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, GRM1, EGFR, IGF1R 2.9846
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET, EGFR 3.0263
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 CXCL8, SRC, MET, EGFR 3.0263
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 CXCL8, FLT3, KIT, KDR, MET, EGFR 2.4697
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, PTAFR, DRD1, GRM1, EGFR 2.4519
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1, CYP3A4 3.0263
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, DRD1, DRD2, PPARA, GRIA4 2.2679
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0263
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 CXCL8, FLT3, MMP9, MET, IGF1R 2.4519
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, HMGCR, CYP3A4 2.9923
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CXCL8, CSNK2A1, BCL2, PTGS2 2.5902
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, DRD1, DRD2, GRIA4 2.1431
Prostate cancer_Homo sapiens_hsa05215 BCL2, EGFR, IGF1R 1.7383
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.7268
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.2004
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.1456
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 1.9893
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.1431
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.9801
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.0922
Rheumatoid arthritis_Homo sapiens_hsa05323 CXCL8, MMP1, TEK 1.7324
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, DRD1, GRIA4 2.0525
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.4622
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.0626
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, HMGCR, IGF1R 1.4115
Hepatitis C_Homo sapiens_hsa05160 CXCL8, PPARA, EGFR 1.3441
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.2824
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 CXCL8, INSR, PPARA 1.2377
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.2047
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2, EGFR 1.2047
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 0.9817
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, HSPA1A 0.8058
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.24
Insulin resistance_Homo sapiens_hsa04931 INSR, PPARA 0.8492
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 0.8471
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2542
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2638
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 0.8453
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2757
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.4519
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, CXCL8 0.8798
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 0.9817
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.7411
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.727
Platelet activation_Homo sapiens_hsa04611 SRC, PTGS1 0.8027
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8091
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.8091
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.6293
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 0.9416
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7335
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2 0.8058
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3136
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 0.9385
Phagosome_Homo sapiens_hsa04145 TUBB3 0.3136
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR 0.6297
Influenza A_Homo sapiens_hsa05164 CXCL8, HSPA1A 0.6094
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.727
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3208
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.6295
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6077
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.6077
Insulin signaling pathway_Homo sapiens_hsa04910 INSR 0.3357
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3357
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.528
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3445
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 0.9817
Small cell lung cancer_Homo sapiens_hsa05222 BCL2, PTGS2 0.9842
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, TERT 0.4522
Chemokine signaling pathway_Homo sapiens_hsa04062 CXCL8, SRC 0.5947
Cell cycle_Homo sapiens_hsa04110 SMAD3 0.3645
Axon guidance_Homo sapiens_hsa04360 MET 0.3593
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3645
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.37
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.055
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 CXCL8 0.4095
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.4235
Melanogenesis_Homo sapiens_hsa04916 KIT 0.4235
Amoebiasis_Homo sapiens_hsa05146 CXCL8 0.4235
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4235
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4235
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4235
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4249
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4241
Morphine addiction_Homo sapiens_hsa05032 DRD1 0.4372
Taste transduction_Homo sapiens_hsa04742 GRM1 0.4522
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4403
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.451
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.1886
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4393
Salmonella infection_Homo sapiens_hsa05132 CXCL8 0.4455
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4382
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.1819
Peroxisome_Homo sapiens_hsa04146 XDH 0.4522
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.2047
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.4773
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4609
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.4773
Pertussis_Homo sapiens_hsa05133 CXCL8 0.4737
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4755
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4672
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4864
Shigellosis_Homo sapiens_hsa05131 CXCL8, SRC 1.1886
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 CXCL8 0.4864
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2377
Legionellosis_Homo sapiens_hsa05134 CXCL8, HSPA1A 1.2764
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5018
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.5042
Malaria_Homo sapiens_hsa05144 CXCL8, MET 1.3452
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.3254
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 CXCL8 0.5476
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.551
Staphylococcus aureus infection_Homo sapiens_hsa05150 PTAFR 0.551
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.551
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.5691
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 2.9846
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.5947
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5947
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5947
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.4928
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.634
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6077
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.6077
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.6735
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7064
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF 1.5906
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.574
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7501
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.659
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7185
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7335
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7567
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9031
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7501
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.808
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.8824
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9488
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.1668
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2377


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)