TCM Prescription: Lan Qin Oral Liquid



Prescription Description
Prescription IDTCMF6968
Pinyin NameLan Qin Kou Fu Ye
Chinese Name蓝芩口服液
English NameLan Qin Oral Liquid
Function Description清热解毒, 利咽消肿。用于急性咽炎, 肺胃实热证所致的咽痛, 咽干, 咽部灼热。
IndicationsHeat pattern, Pharyngitis
Disease ICD-11 Category SE72 [Heat pattern (TM1), 热证 (TM1) ];
CA0Z [Upper respiratory tract disorders, unspecified, 上呼吸道疾患，未特指的 ];
Human Tissues Associated with IndicationLung
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH127 Isatis indigotica 板蓝根 TCMH127 KJ765825
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH949 Phellodendron amurense 黄柏 TCMH949 ITSAM1586-14
TCMH1607 Semen sterculiae lychnophorae 胖大海 TCMH1607
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1241 Human rhinovirus 14
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1333 Human rhinovirus 1A
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, KIT, MMP9, PTGS2, SRC, TERT 10.0645
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DRD1, DRD2, FABP3, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MMP2, MMP9, PPARA, PTGS2, SRC, TERT 9.42975
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, FABP3, FABP4, FUT7, HSD17B1, KIT, MET, PPARA, PTGS2 9.42975
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FLT3, GSK3B, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 9.42975
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, DRD1, DRD2, F3, FABP3, FABP4, FLT3, GSK3B, HSD17B1, KDR, KIT, MET, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 9.42975
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FLT3, GSK3B, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 9.42975
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DRD1, DRD2, FABP3, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MMP2, PPARA, PTGS2, SRC 9.39728
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DRD1, DRD2, FABP3, GSK3B, IDO1, IGF1R, MMP2, MMP9, PPARA, PTGS2, SRC 9.05039
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 7.95124
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, FABP3, FUT7, IDO1, PIM1, PPARA, PTGS2, XDH 7.47161
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, DRD1, FABP3, FLT3, GSK3B, IGF1R, KIT, MMP2, PPARA, PTGS2, SRC 7.45841
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 7.39503
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 7.22804
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, F3, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP9, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 7.18771
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, BCL2, CSNK2A1, CYP1B1, DNMT1, DRD2, F3, FABP3, FLT3, IDO1, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PTGS2, SRC, TERT, XDH 7.15663
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DNMT1, DRD1, DRD2, DYRK1A, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, PIM1, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 7.13604
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MMP2, MMP9, PTGS2, SRC, TERT 7.13604
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, F3, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP9, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 7.13343
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, F3, FLT3, GSK3B, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 7.01342
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 6.98154
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, KIT, MMP9, PTGS2, TERT 6.98154
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 6.98154
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTGS2, SRC, TERT 6.97815
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, FABP3, FABP4, FUT7, KIT, MET, PPARA, PTGS2 6.89847
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, DRD2, DYRK1A, FABP4, FLT3, FUT7, GSK3B, KDR, KIT, MET, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS2 6.8765
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DHFR, DRD1, DRD2, DYRK1A, F3, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP2, MMP9, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 6.74829
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, PIM1, SRC 6.74829
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTGS2, SRC, TERT 6.72123
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CSNK2A1, DHFR, DRD1, DRD2, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, PTGS2, PTPRS, SRC, TNKS, XDH 6.65047
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 6.58035
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 6.57025
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTGS2, SRC, TERT, XDH 6.56433
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, F3, FABP4, FLT3, GSK3B, IDO1, KDR, KIT, MET, MMP2, MMP9, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 6.56433
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTGS2, SRC, TERT, XDH 6.34635
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CSNK2A1, DHFR, DRD1, DRD2, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, PTGS2, PTPRS, SRC, TNKS, XDH 6.32334
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CYP1A1, CYP1B1, DNMT1, DRD1, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MMP2, PTGS2, SRC 6.32334
[BP] GO:0006730 one-carbon metabolic process CA12, CA2, CA4, CA7, CA9, DHFR 6.32334
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, DRD2, FLT3, PTGS2, SRC 6.01912
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, DRD1, DRD2 5.93978
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CYP19A1, DHFR, DRD2, DYRK1A, F3, FABP4, GSK3B, IDO1, IGF1R, MET, MMP2, PPARA, PTGS2, PTPRS, SRC, TERT, XDH 5.87655
[BP] GO:0015701 bicarbonate transport CA12, CA14, CA2, CA4, CA7, CA9 5.82086
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 5.79217
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, GSK3B, HSD17B1, IDO1, PTGS2, XDH 5.75719
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DRD1, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MMP2, MMP9, PTGS2, SRC, TERT 5.69357
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, GSK3B, IGF1R, KDR, KIT, MET, MMP9, PPARA, PTGS2, SRC, TERT 5.69357
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 5.69189
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DHFR, DNMT1, DRD1, DRD2, DYRK1A, FABP3, FABP4, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 5.5772
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 5.55106
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, DRD1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS 5.54586
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1 5.52124
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, GSK3B, MET, MMP9, PPARA, SRC, TERT 5.52124
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 5.44524
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, DRD1, DRD2, KDR, PTGS2, SRC, TNKS, TNKS2 5.41151
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 5.39888
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, DRD2, F3, FLT3, KDR, KIT, MET, PTGS2, SRC, XDH 5.34597
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 5.34432
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, BACE1, BCL2, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DHFR, DRD1, DRD2, DYRK1A, F3, FLT3, FUT7, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPRS, SRC, TNKS, TNKS2, XDH 5.33836
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, DRD2, DYRK1A, FLT3, GSK3B, KDR, KIT, MMP9, PIM1, PPARA, PTGS2, PTPRS, SRC 5.338
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 5.33423
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BACE1, CA2, CA7, DRD1, DRD2, KIT, PTGS2 5.30334
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BACE1, CA2, CA7, DRD1, DRD2, KIT, PTGS2 5.30334
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GSK3B, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, SRC, TERT 5.28905
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DYRK1A, F3, FLT3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, XDH 5.24088
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCL2, CA9, CYP1A1, CYP1B1, DHFR, DRD1, DRD2, FABP3, KDR, PTGS2, SRC 5.22968
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DHFR, DNMT1, DRD1, DRD2, DYRK1A, FABP3, FABP4, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 5.21626
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 5.20636
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, GSK3B, IDO1, MMP1, MMP2, MMP9, SRC, XDH 5.20636
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 5.16575
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, DNMT1, DRD2, GSK3B, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC, TNKS, TNKS2 5.15857
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, GSK3B, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, SRC, TERT, XDH 5.11831
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DHFR, DNMT1, DRD1, DRD2, FABP3, FLT3, GSK3B, IGF1R, MMP2, PPARA, PTGS2, SRC 5.09692
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DRD1, DRD2, F3, FABP3, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MMP2, MMP9, PPARA, PTGS2, SRC, TERT 5.07912
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DRD1, DRD2, IDO1 5.05163
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1 4.98685
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, KIT, PPARA, PTGS2, SRC 4.93785
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DHFR, DRD2, PPARA 4.89892
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, GSK3B, MET, MMP9, PPARA, SRC, TERT, TNKS 4.87106
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SRC, TERT 4.83416
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1, DRD2, PTGS2 4.82351
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 4.79338
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, F3, FABP4, IDO1, IGF1R, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGS2, SRC, TNKS2 4.78074
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 4.74872
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SRC, TERT 4.74784
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DHFR, DNMT1, DRD1, DRD2, FABP3, FLT3, GSK3B, IGF1R, MMP2, PPARA, PTGS2, SRC 4.74784
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.67847
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CSNK2A1, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP9, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 4.61793
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, IDO1, PTGS2, SRC 4.55603
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DYRK1A, F3, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP9, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 4.55603
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DYRK1A, GSK3B, KIT, PPARA, SRC 4.55351
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, DRD1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS 4.55351
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, KIT, MMP2, PPARA, PTGS2, SRC, TERT 4.5456
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DRD2, FABP4, GSK3B, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, SRC, TNKS 4.49409
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, KDR, SRC 4.48713
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SRC, TERT 4.4841
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MET, SRC, TNKS 4.44819
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS2 4.42917
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CSNK2A1, DRD2, F3, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PTGS2, TERT 4.41382
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, F3, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP9, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 4.39511
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, DRD1, DRD2, KDR, SRC 4.34278
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, DRD2, GSK3B, IDO1, KIT, MMP2, MMP9, PPARA, PTGS2, SRC, TERT 4.32723
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, PTGS2, TNKS, TNKS2 4.24557
[BP] GO:0015711 organic anion transport ABCB1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA 4.20037
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 4.20037
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP9, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 4.10233
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 4.07323
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, F3, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP9, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 4.06513
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DRD1, DYRK1A, GSK3B, SRC, TNKS 4.03394
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, GSK3B, PTGS2, SRC, TERT 4.01186
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, APP, AURKB, BCL2, CSNK2A1, CYP1B1, DHFR, DRD1, DRD2, F3, FABP4, FLT3, GSK3B, IGF1R, KIT, MET, MMP9, PIM1, PPARA, PTGS2, SRC, TERT, TNKS, XDH 3.90438
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1 3.89259
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, BCL2, CYP19A1, DRD1, DRD2, DYRK1A, GSK3B, IGF1R, MET, MMP9, PPARA, PTGS2, PTPRS, SRC, TERT, XDH 3.8814
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, BCL2, CSNK2A1, DHFR, DRD1, DRD2, F3, FABP4, FLT3, GSK3B, IGF1R, KIT, MMP9, PTGS2, SRC, TERT, TNKS, XDH 3.76191
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DRD1, DYRK1A, GSK3B, SRC, TNKS 3.74523
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1 3.73581
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 3.72574
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, PPARA, PTGS2 3.72297
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, PTGS2 3.71484
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, DRD1, DRD2, FABP3, FABP4, FLT3, MET, SRC, TERT 3.71016
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, DNMT1, GSK3B, KDR, MET, MMP9, SRC, TNKS, TNKS2 3.62884
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CYP1B1, DNMT1, DRD1, GSK3B, IGF1R, MMP2, MMP9, PTGS2, SRC 3.60829
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, PTGS2, SRC 3.60829
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DNMT1, DRD1, GSK3B, IGF1R, MMP2, PTGS2, SRC 3.49542
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.46991
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, F3, FABP4, IDO1, KDR, MET, PPARA, PTGS2, PTPRS 3.44629
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CBR1, CYP1A1, DRD1, DRD2, FABP4, FLT3, FUT7, GSK3B, KDR, KIT, MET, MMP2, MMP9, PTGS2, PTPRS, SRC, TERT 3.44629
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, BCL2, CSNK2A1, DNMT1, DRD2, DYRK1A, F3, FLT3, GSK3B, KDR, KIT, MMP9, PTGS2, SRC, XDH 3.43234
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, F3, KIT, MET, SRC, XDH 3.40862
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, DRD1, DRD2, FABP3, FLT3, KDR, KIT, MMP9, PTGS2, SRC, XDH 3.40862
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, DRD1, DRD2, FABP3, FLT3, KDR, KIT, MMP9, PTGS2, SRC, XDH 3.40862
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.4039
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.4039
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2, TERT 3.39707
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DRD1, DRD2, DYRK1A, GSK3B, IGF1R, MET, MMP9, PTGS2, PTPRS, SRC, TERT, XDH 3.36106
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DRD1, DRD2, DYRK1A, GSK3B, IGF1R, MET, MMP9, PTGS2, PTPRS, SRC, TERT, XDH 3.34915
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, DYRK1A, GSK3B, TNKS 3.34915
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CYP19A1, DRD1, DRD2, GSK3B, MMP9, PPARA, PTGS2, SRC, TERT 3.30637
[BP] GO:0006820 anion transport ABCB1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA 3.29572
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.28782
[BP] GO:0032845 None ADORA1, BCL2, DRD2, SRC, TNKS, TNKS2 3.2742
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DNMT1, DRD1, GSK3B, IGF1R, MMP2, PTGS2, SRC 3.27167
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, DNMT1, DRD1, FLT3, GSK3B, IGF1R, KIT, MMP2, PTGS2, SRC 3.26568
[BP] GO:0001101 response to acid chemical AKR1B1, DHFR, DNMT1, FABP3, KDR, MMP2, PTGS2, SRC 3.24763
[BP] GO:0001816 cytokine production APP, FABP4, IDO1, KIT, PTGS2 3.23896
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, DRD1, DRD2, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PPARA, PTGS2, SRC, XDH 3.22759
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.22073
[BP] GO:0044283 None AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, DHFR, IDO1, PTGS2 3.19791
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, DYRK1A, GSK3B, TNKS 3.19791
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, BCL2, CYP1B1, DRD2, FABP3, IDO1, PTGS2, TERT, XDH 3.16392
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, BCL2, DNMT1, DRD2, DYRK1A, F3, FLT3, GSK3B, KDR, KIT, MMP9, PTGS2, SRC, XDH 3.14102
[BP] GO:0048167 None ADORA1, APP, DRD1, DRD2, KIT, PTGS2 3.13742
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CYP1B1, DRD2, F3, IDO1, KDR, KIT, MET, MMP9, PIM1, PTGS2, SRC, TERT 3.13742
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, IDO1, PIM1, PPARA, PTGS2 3.12606
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, KDR, KIT, PPARA, PTPRS, SRC 3.10951
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, DRD1, DRD2, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PPARA, PTGS2, SRC, XDH 3.10951
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, APP, AURKB, BCL2, DHFR, DRD2, F3, FLT3, GSK3B, KIT, MET, MMP9, SRC, TERT, TNKS, XDH 3.08995
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, MMP9, PTGS2, SRC 3.08995
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, GSK3B, IDO1, XDH 3.0868
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, DRD1, DRD2, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PPARA, PTGS2, SRC, XDH 3.07212
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CSNK2A1, DRD2, F3, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP2, MMP9, SRC, TNKS, TNKS2 3.06063
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 3.06063
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, DRD1, DRD2, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PTGS2, SRC, XDH 3.06063
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GSK3B, IGF1R, PPARA, PTGS2, SRC 3.04857
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, BCL2, DNMT1, DRD2, DYRK1A, FLT3, KDR, KIT, MMP9, PTGS2, SRC, XDH 3.04306
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, DRD1, FLT3, PTGS2, SRC 3.03711
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, BCL2, DNMT1, DRD1, DRD2, DYRK1A, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PTGS2, SRC, XDH 3.0275
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, BCL2, CA2, CYP1B1, DRD2, F3, GSK3B, IDO1, KDR, KIT, MET, MMP9, PIM1, PTGS2, PTPRS, SRC, TERT, TNKS2, XDH 2.97942
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, APP, BCL2, CA2, CA7, DRD1, DRD2, MMP9, PTGS2 2.95747
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, TUBB3, XDH 2.9524
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, KIT, PPARA, PTGS2, SRC 2.94396
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.93998
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.91977
[BP] GO:0008542 None APP, DRD1, DRD2, KIT 2.89968
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.89744
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, KDR, KIT, PTGS2, TERT 2.88535
[BP] GO:0032225 None DRD1, DRD2, PTGS2 2.86529
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.86529
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, APP, BCL2, CSNK2A1, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MMP9, PTGS2, SRC, XDH 2.8637
[BP] GO:0051094 positive regulation of developmental process APP, AXL, BCL2, CA2, CYP1B1, DRD2, F3, IDO1, KDR, KIT, PIM1, PTGS2, SRC, TERT 2.8637
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AURKB, BCL2, CSNK2A1, DHFR, DNMT1, DRD2, DYRK1A, FABP4, GSK3B, IGF1R, KDR, MET, MMP9, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 2.8523
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, SRC 2.84283
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2 2.80281
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.8016
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.79599
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.79163
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.79163
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, IDO1, PTGS2, SRC 2.79163
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, HSD17B1 2.79163
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, DRD2, FLT3, KDR, KIT, MMP9, PTGS2, SRC, XDH 2.78989
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AURKB, AXL, BACE1, BCL2, CSNK2A1, DRD1, DYRK1A, F3, FLT3, FUT7, GSK3B, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPRS, SRC, TNKS, TNKS2 2.78908
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, IDO1, PIM1, PPARA, PTGS2 2.78638
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, DRD2, FLT3, KDR, KIT, SRC, XDH 2.78638
[BP] GO:0007632 None APP, DRD1, DRD2, KIT 2.7727
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.7727
[BP] GO:0080135 regulation of cellular response to stress APP, DHFR, DYRK1A, GSK3B, IGF1R, MET, PTGS2, PTPRS, TERT, XDH 2.7727
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, KDR, PTGS2, SRC 2.76017
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, DYRK1A, IGF1R, MET, MMP9, PTGS2, SRC, XDH 2.75568
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, FLT3, KIT, MET, PIM1, SRC 2.74966
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD1, DRD2, KIT, PTGS2 2.73617
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, IDO1, PIM1, PPARA, PTGS2 2.72862
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.71155
[BP] GO:2000026 regulation of multicellular organismal development APP, AXL, BCL2, CA2, CYP1B1, DRD2, F3, GSK3B, IDO1, KDR, KIT, PIM1, PTGS2, PTPRS, SRC, TERT, XDH 2.70492
[BP] GO:0051128 regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, DNMT1, DRD2, GSK3B, IGF1R, KDR, KIT, MET, MMP1, MMP9, PTPRS, SRC, TNKS, TNKS2 2.70492
[BP] GO:0046686 response to cadmium ion CYP1A2, KIT, MMP9, TERT 2.70071
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.69272
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, FABP3, FABP4, KIT, MET 2.69047
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, IDO1, PTGS2, SRC 2.65317
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, MET 2.65317
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.65317
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, DRD2, FLT3, KDR, KIT, MMP9, PTGS2, SRC, XDH 2.64644
[BP] GO:0034502 protein localization to chromosome AURKB, TERT, TNKS, TNKS2 2.62789
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, PTGS2 2.62789
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.60058
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A1, DRD1, IDO1, KIT, MMP2, MMP9, PTGS2, SRC 2.59312
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.57946
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.57946
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1 2.57884
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SRC, XDH 2.5779
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD17B1, PTGS2 2.57342
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.55699
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.55699
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.52669
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2, TERT 2.51086
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.50819
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, DNMT1, IGF1R, SRC, TNKS, TNKS2 2.50819
[BP] GO:0031324 negative regulation of cellular metabolic process APP, AURKB, BCL2, CSNK2A1, DHFR, DNMT1, DRD2, DYRK1A, FABP4, GSK3B, IGF1R, MET, MMP9, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 2.48781
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.47505
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, DRD2, FLT3, IGF1R, KDR, KIT, SRC, XDH 2.46509
[BP] GO:0050793 regulation of developmental process APP, AXL, BCL2, CA2, CYP1B1, DRD2, F3, GSK3B, IDO1, KDR, KIT, PIM1, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS2, XDH 2.44985
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, PTGS2, SRC 2.44891
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, APP, AURKB, AXL, BACE1, BCL2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FLT3, FUT7, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 2.44698
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, DRD2, TNKS2 2.44205
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ALOX15, APP, BCL2, CSNK2A1, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MMP9, PTGS2, SRC, XDH 2.43191
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.4307
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.4307
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, DHFR, FLT3 2.41028
[BP] GO:0007612 None APP, DRD1, DRD2, KIT, PTGS2 2.41028
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, BCL2, DHFR, DRD2, F3, FLT3, GSK3B, KIT, SRC, TERT, TNKS, XDH 2.41028
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, IDO1 2.40966
[BP] GO:0070213 None TNKS, TNKS2 2.40966
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.40966
[BP] GO:1901342 regulation of vasculature development CYP1B1, F3, KDR, KIT, PTGS2, TERT, XDH 2.40716
[BP] GO:0048169 None APP, DRD2, KIT 2.393
[BP] GO:0007416 None ACHE, APP, DRD1, DRD2 2.39173
[BP] GO:0008306 None APP, DRD1, DRD2, KIT 2.369
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, DRD2, MMP9, PTGS2 2.3524
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.35105
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.35105
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.35105
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APP, AURKB, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 2.31809
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, F3, GSK3B, IDO1, MMP9, PTGS2, SRC, XDH 2.31051
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, PTGS2, SRC, XDH 2.30828
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.30815
[BP] GO:1904646 cellular response to amyloid-beta APP, GSK3B, IGF1R 2.30815
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AURKB, AXL, BACE1, BCL2, CSNK2A1, DRD1, DYRK1A, FLT3, FUT7, GSK3B, IGF1R, KDR, KIT, MET, MMP1, MMP2, PIM1, PTPRS, SRC, TNKS, TNKS2 2.2967
[BP] GO:0031214 biomineral tissue development ALOX15, ALPL, PPARA, PTGS2 2.29285
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, F3, GSK3B, IDO1, MMP9, PTGS2, SRC, XDH 2.2879
[BP] GO:0034097 response to cytokine ALOX15, AXL, BCL2, FABP4, FLT3, GSK3B, PTGS2, SRC 2.2678
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.25265
[BP] GO:0032204 None AURKB, SRC, TNKS, TNKS2 2.23357
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2 2.23357
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, APP, AURKB, BCL2, CA9, CSNK2A1, CYP1A1, CYP1B1, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 2.23333
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F3, KIT, MET, SRC 2.23333
[BP] GO:0021853 None DRD1, DRD2 2.23333
[BP] GO:0099565 chemical synaptic transmission, postsynaptic DRD2, GSK3B 2.23333
[BP] GO:0010641 None F3, SRC 2.23333
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.23333
[BP] GO:1904936 None DRD1, DRD2 2.23333
[BP] GO:0042321 None ADORA1, DRD2 2.23333
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, FABP3, FABP4, MET 2.22951
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.22719
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ALOX15, APP, AURKB, BCL2, CA9, CSNK2A1, CYP1A2, CYP1B1, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 2.22539
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, F3, KDR, PTGS2, TERT 2.212
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, FABP4, IDO1, MMP2, PPARA, PTGS2, PTPRS, SRC 2.20458
[BP] GO:0051100 negative regulation of binding AURKB, GSK3B, MET, PPARA, TNKS 2.20458
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, PTGS2, SRC 2.20458
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC 2.20458
[BP] GO:1904645 response to amyloid-beta APP, GSK3B, IGF1R 2.20458
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, APP, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 2.20344
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7 2.17746
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DHFR, DRD1, DRD2, PTGS2 2.1692
[BP] GO:0001659 None ADORA1, DRD1, DRD2 2.1692
[BP] GO:0010039 response to iron ion BCL2, CYP1A1, DRD2 2.1692
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX15, CYP19A1, CYP3A4, DHFR 2.12748
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, IDO1, XDH 2.12748
[BP] GO:0032092 positive regulation of protein binding APP, GSK3B, MMP9, TERT 2.12717
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GSK3B, IDO1, SRC, XDH 2.12636
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, MMP9 2.12379
[BP] GO:0051099 positive regulation of binding APP, GSK3B, MET, MMP9, TERT 2.12081
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC 2.10282
[BP] GO:0006775 fat-soluble vitamin metabolic process CBR1, CYP1A1, CYP3A4 2.10282
[BP] GO:0030177 positive regulation of Wnt signaling pathway CSNK2A1, SRC, TERT, TNKS, TNKS2 2.10282
[BP] GO:0030336 None ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD2 2.10282
[BP] GO:0021843 None DRD1, DRD2 2.10282
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.10282
[BP] GO:0021830 None DRD1, DRD2 2.10282
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.10282
[BP] GO:0021826 None DRD1, DRD2 2.10282
[BP] GO:2001300 lipoxin metabolic process ALOX15, ALOX5 2.10282
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP3A4 2.10282
[BP] GO:0010942 positive regulation of cell death BCL2, CYP1B1, F3, GSK3B, IDO1, MMP9, PTGS2, SRC, XDH 2.10282
[BP] GO:0046394 None ALOX15, ALOX5, CYP1A1, DHFR, IDO1, PTGS2 2.09635
[BP] GO:0016053 None ALOX15, ALOX5, CYP1A1, DHFR, IDO1, PTGS2 2.08869
[BP] GO:0032212 positive regulation of telomere maintenance via telomerase AURKB, TNKS, TNKS2 2.07798
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, DHFR, PTGS2, XDH 2.06837
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ALOX15, APP, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 2.06829
[BP] GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, MMP9, PTGS2, SRC 2.05955
[BP] GO:0050890 None ADORA1, APP, DRD1, DRD2, KIT, PTGS2 2.05331
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, SRC 2.05134
[BP] GO:0009968 negative regulation of signal transduction BCL2, DRD2, DYRK1A, GSK3B, IGF1R, MET, MMP9, PTGS2, PTPRS, SRC, TERT, XDH 2.05045
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2 2.04962
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, FUT7, KDR, KIT, MMP1, MMP9, SRC 2.04801
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CYP1B1, DRD1, DRD2, FUT7, KDR, KIT, MMP1, MMP9, PTGS2, SRC, TUBB3 2.02793
[BP] GO:0006066 None AKR1B1, AKR1B10, APP, CYP1B1, CYP3A4, DHFR 2.02793
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA12, CA2, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FLT3, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 2.02793
[BP] GO:0014911 positive regulation of smooth muscle cell migration BCL2, SRC, TERT 2.02335
[BP] GO:0032205 None SRC, TNKS, TNKS2 2.02335
[BP] GO:1904358 positive regulation of telomere maintenance via telomere lengthening AURKB, TNKS, TNKS2 2.02335
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, DRD2, FABP4, FLT3, GSK3B, IGF1R, KIT, SRC, TNKS 2.02219
[BP] GO:0052548 None APP, CSNK2A1, F3, MMP9, PTGS2, SRC, XDH 2.01768
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, PPARA, PTPRS 2.0122
[BP] GO:0032103 positive regulation of response to external stimulus F3, FABP4, IDO1, KDR, MET, PTGS2 2.0122
[BP] GO:2000146 None ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD2 2.00493
[BP] GO:0022603 regulation of anatomical structure morphogenesis BCL2, CYP1B1, F3, KDR, KIT, PIM1, PTGS2, PTPRS, SRC, TERT, XDH 2.00191
[BP] GO:0007610 None APP, BCL2, DRD1, DRD2, IDO1, KIT, PPARA, PTGS2 2.00165
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, FUT7, KDR, KIT, MET, MMP1, MMP9, SRC 2.00165
[BP] GO:0034405 response to fluid shear stress CA2, PTGS2, SRC 2.00165
[BP] GO:0007212 None DRD1, DRD2, GSK3B 2.00165
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGS2 2.00165
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, SRC 2.00165
[BP] GO:0009820 alkaloid metabolic process CYP1A2, CYP3A4 2.00165
[BP] GO:1904180 negative regulation of membrane depolarization BCL2, SRC 2.00165
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA2, CA4, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FLT3, FUT7, GSK3B, IDO1, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, TUBB3, XDH 3.41689
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, F3, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP2, PIM1, PTPRS, SRC, TERT 3.30588
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA2, CA4, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FLT3, FUT7, GSK3B, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, TUBB3, XDH 3.11695
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, F3, FLT3, FUT7, GSK3B, IGF1R, KDR, KIT, MET, MMP2, PIM1, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2 3.04347
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ALOX15, APP, AXL, BACE1, CA2, CA4, CA9, DRD1, DRD2, F3, FLT3, IGF1R, KDR, KIT, MET, PTGS2, PTPRS, SRC 2.89968
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, BACE1, CA4, DRD1, DRD2, F3, FLT3, IGF1R, KDR, MET, PTPRS 2.29285
[CC] GO:0030424 None APP, BACE1, CA2, DRD2, PTPRS, TUBB3 2.15274
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AURKB, BACE1, BCL2, CA2, CA4, CA7, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DRD1, DRD2, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, IDO1, KDR, KIT, MMP2, MMP9, PIM1, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 2.02335
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, BACE1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DNMT1, DYRK1A, F3, FLT3, FUT7, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, TUBB3, XDH 12.8717
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DNMT1, DRD1, DRD2, DYRK1A, F3, FABP3, FABP4, FLT3, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, TUBB3, XDH 12.4791
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, MMP1, MMP2, MMP9, PIM1, PPARA, TNKS, XDH 8.66717
[MF] GO:0004089 carbonate dehydratase activity CA12, CA14, CA2, CA4, CA7, CA9 8.34874
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DRD1, DRD2, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, PPARA, SRC 6.8765
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, HSD17B1, IDO1, PTGS2, XDH 6.00476
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, IDO1, PTGS2, SRC 5.77788
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.61329
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, IDO1, PTGS2, SRC 5.5772
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.39888
[MF] GO:0016836 hydro-lyase activity CA12, CA14, CA2, CA4, CA7, CA9 5.35901
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, APP, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DRD2, IDO1, KIT, MMP1, MMP2, MMP9, PIM1, PPARA, PTGS2, TERT, TNKS, TNKS2, XDH 5.28905
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 5.21626
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 5.14561
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 4.87106
[MF] GO:0016835 carbon-oxygen lyase activity CA12, CA14, CA2, CA4, CA7, CA9 4.72405
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.60081
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, HSD17B1, IDO1, PTGS2, SRC, XDH 4.55129
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.40679
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC 4.19632
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, APP, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, IDO1, KIT, MMP1, MMP2, MMP9, PIM1, PPARA, PTGS2, TERT, TNKS, TNKS2, XDH 3.87499
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, IDO1, PTGS2 3.79896
[MF] GO:0043168 anion binding ABCB1, ALOX15, APP, AURKB, AXL, CSNK2A1, DHFR, DYRK1A, F3, FABP3, FABP4, FLT3, GSK3B, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, PTPRS, SRC, TUBB3, XDH 3.77411
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, IDO1, PTGS2 3.74314
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.52084
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC 3.44629
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AURKB, AXL, CSNK2A1, DHFR, DNMT1, DYRK1A, FABP3, FABP4, FLT3, GSK3B, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, TUBB3, XDH 3.41675
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC, TERT 3.13742
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC 3.13158
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS2 3.12706
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 3.01608
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, IDO1, XDH 2.79163
[MF] GO:0016829 lyase activity CA12, CA14, CA2, CA4, CA7, CA9 2.79163
[MF] GO:0000166 nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DHFR, DNMT1, DYRK1A, FLT3, GSK3B, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, TUBB3, XDH 2.72885
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AURKB, AXL, CSNK2A1, DHFR, DNMT1, DYRK1A, FLT3, GSK3B, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, TUBB3, XDH 2.72862
[MF] GO:0008270 zinc ion binding CA12, CA2, CA4, CA7, CA9, DNMT1, MMP1, MMP2, MMP9, PPARA, TNKS 2.71155
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.65317
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.65317
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, XDH 2.41028
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.40966
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.40966
[MF] GO:0042802 identical protein binding ACHE, APP, BCL2, CSNK2A1, DRD2, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, TERT, XDH 2.39173
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.23333
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CSNK2A1, DYRK1A, F3, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PTPRS, SRC 2.19086
[MF] GO:0097367 carbohydrate derivative binding ABCB1, ADORA1, APP, AURKB, AXL, CSNK2A1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, PTPRS, SRC, TUBB3 2.12748
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP3A4 2.07798
[MF] GO:0051213 dioxygenase activity ALOX15, ALOX5, IDO1, PTGS2 2.05955
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DNMT1, DRD1, DRD2, DYRK1A, FLT3, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, PIM1, PPARA, PTGS2, SRC, TERT, TUBB3, XDH 2.02793
[MF] GO:0005021 vascular endothelial growth factor-activated receptor activity FLT3, KDR 2.00165
[MF] GO:0001609 None ADORA1, ADORA3 2.00165


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.1784
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA2, CA4, CA7, CA9, CA14 9.1605
Metabolic pathways_Homo sapiens_hsa01100 CBR1, DNMT1, ALOX15, AKR1B1, PTGS2, CYP3A4, CYP19A1, DHFR, FUT7, AKR1B10, ALOX5, HSD17B1, CYP1A2, CYP1A1, ALPL, XDH, IDO1 5.9212
Pathways in cancer_Homo sapiens_hsa05200 GSK3B, FLT3, MMP1, MMP2, KIT, BCL2, PTGS2, MMP9, MET, IGF1R 5.4292
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 6.162
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 5.4695
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, ABCB1, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET 4.4482
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.4482
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1, IDO1 4.1096
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.5538
Focal adhesion_Homo sapiens_hsa04510 GSK3B, SRC, KDR, BCL2, MET, IGF1R 3.5538
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.1096
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KIT, KDR, DRD2, MET, IGF1R 3.5264
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, PTGS2 3.5264
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.2886
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.8604
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3802
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, KIT, KDR, BCL2, MET, IGF1R 2.5832
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3, DRD1, DRD2 3.0694
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15, PTGS2 2.7095
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.373
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, PTGS2 2.4779
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.4738
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.4174
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.1076
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.2095
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET 2.3507
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, DRD1, DRD2, PPARA 2.002
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, CYP3A4 2.373
Prostate cancer_Homo sapiens_hsa05215 GSK3B, BCL2, IGF1R 2.0511
Ras signaling pathway_Homo sapiens_hsa04014 KIT, KDR, MET, IGF1R 1.8441
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 1.9574
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, CYP3A4 2.2922
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 2.0097
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.6505
Dopaminergic synapse_Homo sapiens_hsa04728 GSK3B, DRD1, DRD2 1.7025
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, DRD1, DRD2 1.6038
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.7791
Hepatitis B_Homo sapiens_hsa05161 SRC, BCL2, MMP9 1.5943
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, GSK3B, APP 1.454
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, CSNK2A1, BCL2 1.2949
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.3355
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, SRC 1.2095
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1952
Melanogenesis_Homo sapiens_hsa04916 GSK3B, KIT 1.127
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, SRC 1.3321
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 1.0717
Insulin resistance_Homo sapiens_hsa04931 GSK3B, PPARA 1.0726
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 1.0722
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.1105
Small cell lung cancer_Homo sapiens_hsa05222 BCL2, PTGS2 1.2113
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.1952
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3541
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.2077
Colorectal cancer_Homo sapiens_hsa05210 GSK3B, BCL2 1.4217
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2826
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, SRC 1.0431
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, CYP3A4 1.3506
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B, BCL2 1.0362
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 1.0431
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0431
Measles_Homo sapiens_hsa05162 GSK3B, CSNK2A1 0.9638
Hepatitis C_Homo sapiens_hsa05160 GSK3B, PPARA 0.9727
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 0.9983
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.9535
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.454
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B, PPARA 0.9126
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9535
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, IGF1R 0.9535
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B, CSNK2A1 0.9535
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.9
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2 0.9
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.8636
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.8277
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.8277
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, SRC 0.8058
HTLV-I infection_Homo sapiens_hsa05166 GSK3B, TERT 0.6373
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.5909
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.3384
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3489
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3967
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3894
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3792
Calcium signaling pathway_Homo sapiens_hsa04020 DRD1 0.3851
Influenza A_Homo sapiens_hsa05164 GSK3B 0.3894
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B 0.4254
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4455
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4326
Insulin signaling pathway_Homo sapiens_hsa04910 GSK3B 0.4455
Phagosome_Homo sapiens_hsa04145 TUBB3 0.4254
Phospholipase D signaling pathway_Homo sapiens_hsa04072 KIT 0.4389
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.6153
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4571
Platelet activation_Homo sapiens_hsa04611 SRC 0.4789
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4789
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4789
Cell cycle_Homo sapiens_hsa04110 GSK3B 0.4789
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.5411
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.537
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5411
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B 0.5296
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5421
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5418
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5415
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.537
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5549
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5556
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5552
Peroxisome_Homo sapiens_hsa04146 XDH 0.5743
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B 0.6123
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9038
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5894
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6123
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.611
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6205
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6373
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6354
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.6338
Glioma_Homo sapiens_hsa05214 IGF1R 0.6373
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6373
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6476
Shigellosis_Homo sapiens_hsa05131 SRC 0.6373
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7815
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8601
Endometrial cancer_Homo sapiens_hsa05213 GSK3B 0.6914
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.678
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.678
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6946
Malaria_Homo sapiens_hsa05144 MET 0.7016
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0706
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.6981
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.7357
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.7314
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.8199
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8551
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9024
Folate biosynthesis_Homo sapiens_hsa00790 DHFR, ALPL 2.4174
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 0.9727
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2095


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)