TCM Prescription: Tong Mai Qiang Shen Wine



Prescription Description
Prescription IDTCMF6962
Pinyin NameTong Mai Qiang Shen Jiu
Chinese Name通脉强肾酒
English NameTong Mai Qiang Shen Wine
Function Description补肾填精, 活血通脉。适用于肾虚引起的腰膝酸软, 畏寒肢冷, 头晕耳鸣, 精神萎靡, 夜尿频多等症; 对心肾阳虚型冠心病也有辅助治疗作用。
IndicationsTinnitus disorder, Kidney yang deficiency pattern, Heart and kidney yang deficiency pattern, Coronary heart disease
Disease ICD-11 Category SC75 [Tinnitus disorder (TM1), 耳鸣 (TM1) ];
SF97 [Kidney yang deficiency pattern (TM1), 肾阳虚证 (TM1) ];
SF6M [Heart and kidney yang deficiency pattern (TM1), 心肾阳虚证 (TM1) ];
BA80.Z [Coronary atherosclerosis, unspecified site, 冠状动脉粥样硬化,未特指部位 ];
Human Tissues Associated with IndicationHeart
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2326 NA 雄蚕蛾 TCMH2326
TCMH2507 Epimedium brevicornum 淫羊藿 TCMH2507 AY362429
TCMH2149 Cuscuta australis 菟丝子 TCMH2149 ITSAP4209-14
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH494 Cordyceps sinensis 冬虫夏草 TCMH494 AF291749
TCMH1740 Cistanche deserticola 肉苁蓉 TCMH1740 ITSAM2511-14
TCMH873 Radix et rhizoma rhodiolae 红景天 TCMH873
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH2226 Stigma croci 西红花 TCMH2226
TCMH184 crystal sugar 冰糖 TCMH184
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT632 PNP Purine nucleoside phosphorylase Transferase P00491
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1191 Bacillus megaterium
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1260 Streptococcus agalactiae
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, MIF, PPARA 7.57589
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.10999
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, MIF, PIM1, PPARA, TYR, XDH 6.93995
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.40112
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.15099
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA9, CBR1, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD17B2, KDR, MET, MIF, MMP2, MMP9, PIM1, PPARA, SRC, TYR 6.12436
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 6.03876
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD17B2, IGF1R, MMP2, MMP9, PPARA, SRC, TYR 5.87818
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HCAR2, HSD17B1, HSD17B2, KDR, MET, MIF, PPARA, SRC, XDH 5.47637
[BP] GO:0010033 response to organic substance AKR1B1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, PPARA, SRC, TYR 5.274
[BP] GO:0008283 cell proliferation ACHE, AURKB, CHRM1, CHRM3, CHRM5, CYP1A1, ESR1, FLT3, MET, MIF, PIM1, SRC, TYR 5.14673
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, CHRM1, CSNK2A1, CYP1B1, ESR1, ESRRA, FABP3, FLT3, IGF1R, KDR, MIF, MMP2, MMP9, PIM1, SRC, XDH 5.14673
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALOX5, AOX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TYR, XDH 5.06066
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 5.00727
[BP] GO:0008202 steroid metabolic process AKR1B1, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD17B1, HSD17B2 5.00683
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC 4.81923
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX5, AOX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP2, PIM1, PPARA, SRC, TYR, XDH 4.81667
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, PPARA, SRC, TYR 4.81667
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, SRC, TYR 4.81667
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.81653
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, APP, AXL, CA2, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, MMP9, PIM1, PPARA, SRC, TYR 4.62585
[BP] GO:0042221 response to chemical AKR1B1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, SRC, TYR 4.62208
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, XDH 4.62208
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, XDH 4.58767
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, SRC, XDH 4.54851
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.393
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP9, PIM1, SRC, XDH 4.26863
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APP, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC 4.26863
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, MIF 4.10815
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1A1, CYP1A2, CYP1B1, TYR 4.06172
[BP] GO:0014070 response to organic cyclic compound APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, SRC, TYR 4.05707
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, MIF 3.97346
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 3.92724
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MIF, MMP9, SRC, XDH 3.91567
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MIF, MMP9, SRC, XDH 3.91567
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.91567
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.91567
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.84499
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, SRC 3.76554
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD17B1, HSD17B2 3.76554
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MIF, MMP9, PIM1, SRC, XDH 3.76554
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MET, MIF, PPARA 3.73376
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.71292
[BP] GO:0009725 response to hormone AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, PPARA, SRC 3.71249
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.71249
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, ALOX5, APP, AXL, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, FABP4, HSD17B2, IGF1R, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TYR 3.68391
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PPARA 3.65401
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.56499
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 3.56499
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MIF, MMP9, PIM1, SRC 3.43706
[BP] GO:0009056 catabolic process ACHE, ADORA1, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MMP1, MMP2, MMP9, SRC, XDH 3.43162
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5 3.42153
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, CHRM1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, SRC 3.3457
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TYR, XDH 3.32572
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.32152
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, CA1, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP2, MMP9, PIM1, PPARA, SRC 3.20962
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, MIF 3.19532
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, ESR1 3.17642
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, SRC 3.15205
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, FABP3, FLT3, HCAR2, PPARA, SRC 3.09573
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 3.0274
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.99607
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, SRC 2.96451
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, SRC 2.91924
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.9104
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MIF, MMP9, SRC, XDH 2.87447
[BP] GO:0009115 None AOX1, XDH 2.86674
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.80789
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, IGF1R, KDR, MIF, MMP9, PIM1, SRC 2.79294
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.79294
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP9, SRC, XDH 2.79294
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.79294
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.79294
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.77552
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, ALOX5, AOX1, APP, AURKB, AXL, CBR1, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TYR, XDH 2.75985
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, CA2, CHRM1, CHRM2, CHRM3, CYP1B1, ESR1, ESRRA, ESRRB, HCAR2, KDR, MET, MIF, MMP9, PIM1, SRC, XDH 2.74896
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP9, SRC, XDH 2.72544
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1 2.6957
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CHRM1, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MIF, MMP2, MMP9, PIM1 2.6957
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, HCAR2, IGF1R, KDR, MET, MIF, MMP9, PPARA, SRC 2.68803
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, SRC 2.66202
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC 2.62953
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, APP, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, SRC 2.62953
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, CA2, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MIF, MMP2, MMP9, PPARA, SRC, TYR 2.52705
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.51066
[BP] GO:0046110 None AOX1, XDH 2.47942
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.47942
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.46322
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3 2.41842
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.40722
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, HCAR2, KDR, MIF, SRC 2.39909
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MET, SRC 2.3849
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PPARA 2.37979
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.36632
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AXL, CYP1B1, FLT3, KDR, MET, MIF, SRC, XDH 2.36632
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.31981
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, SRC, XDH 2.29815
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, SRC 2.28229
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, SRC 2.28229
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, ALOX5, AOX1, APP, AURKB, AXL, CBR1, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TYR, XDH 2.25003
[BP] GO:0006145 None AOX1, XDH 2.25003
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.25003
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.25003
[BP] GO:0071310 cellular response to organic substance AKR1B1, APP, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, SRC 2.23094
[BP] GO:0051716 cellular response to stimulus AKR1B1, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MIF, MMP2, MMP9, SRC 2.20187
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5 2.17994
[BP] GO:0046903 None ALOX5, APP, AXL, CA2, CA9, CHRM1, CHRM3, CHRM5, MIF, MMP9, XDH 2.16325
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PIM1, PPARA, TYR 2.15682
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA 2.14234
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.13178
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, MIF 2.13178
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, MIF 2.13178
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AXL, CSNK2A1, CYP1B1, ESRRA, FABP4, FLT3, KDR, MET, MIF, MMP2, MMP9, SRC, XDH 2.12217
[BP] GO:0016042 lipid catabolic process ADORA1, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.10433
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HCAR2, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, SRC, XDH 2.10238
[BP] GO:0046541 None CHRM1, CHRM3 2.09242
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, MIF 2.05764
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.03886
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, CHRM5, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MIF, MMP9, PPARA, SRC, XDH 2.03886
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AXL, CSNK2A1, CYP1B1, FLT3, KDR, MET, MIF, MMP9, SRC, XDH 2.03079
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.0159
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, CHRM5, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MIF, MMP9, PPARA, SRC, XDH 2.01056
[BP] GO:0010907 None ESRRB, PPARA, SRC 2.01056
[CC] GO:0045202 None ACHE, APP, CHRM1, CHRM2, CHRM3, CHRM5 2.16325
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, IGF1R, KDR, MET 2.13249
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MMP2, PIM1, SRC 2.13178
[CC] GO:0098793 None ADORA1, APP, CHRM1, CHRM2, CHRM3 2.09242
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, CHRM3 1.91045
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PPARA, TYR, XDH 12.6955
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.5257
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP2, MMP9, PIM1, SRC, TYR, XDH 7.10999
[MF] GO:0043167 ion binding ACHE, ALOX5, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TYR, XDH 6.75004
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.66204
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.40112
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.93126
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA 5.06066
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KDR, MET, PPARA 4.80457
[MF] GO:0043169 cation binding ACHE, ALOX5, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PPARA, TYR, XDH 4.30873
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC 4.26863
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 4.22696
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KDR, MET, PPARA 4.18172
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 4.12813
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 4.12813
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 4.12813
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KDR, MET, PPARA 4.05591
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TYR, XDH 4.05591
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.91567
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.84292
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.84292
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.76554
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KDR, MET, PPARA 3.76554
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.75538
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.55174
[MF] GO:0046872 metal ion binding ALOX5, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PPARA, TYR, XDH 3.5163
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AOX1, CBR1, HSD17B1, HSD17B2, XDH 3.46762
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.3457
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 3.19532
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1 3.19532
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 3.00695
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.93703
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.86674
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.86674
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.79294
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5 2.62113
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.49718
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.37047
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, SRC, XDH 2.36632
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP9, PIM1, PPARA, SRC 2.32481
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.27905
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, CSNK2A1, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MIF, MMP9, TYR, XDH 2.26483
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.25003
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5 2.20187
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HSD17B1, PPARA 2.19206
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.1904
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, HCAR2, IGF1R, KDR, MET 2.14234
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, HCAR2, IGF1R, KDR, MET 2.14234
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.09242
[MF] GO:0042562 hormone binding ACHE, CHRM3, HSD17B1, IGF1R 2.0889


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 12.125
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.7418
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.6499
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.7602
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.2349
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5 3.9606
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 4.1465
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.2349
Metabolic pathways_Homo sapiens_hsa01100 CBR1, FUT7, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, AKR1B1, TYR, CYP19A1, XDH 3.4983
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1 3.4983
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.4983
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.5016
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM3, CHRM1, ADORA3, CHRM5, ADORA1 3.3443
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, CHRM1, ADORA1, PPARA 3.0728
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1 3.3653
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5 2.95
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.6117
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, CHRM1, CHRM5 2.3059
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF, TYR 3.2072
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, KDR, MET, IGF1R 2.1744
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.3933
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.5021
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.3059
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 2.1744
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 2.1215
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.8162
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET 1.6216
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.2901
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.4924
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.4488
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4917
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.3975
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.3631
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.3857
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3975
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.1732
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5 1.4487
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.156
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.2373
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.3975
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.3421
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5 1.1096
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 1.2042
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 1.0866
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0866
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.9626
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.0822
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.9759
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.9097
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9842
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.8844
Taste transduction_Homo sapiens_hsa04742 CHRM3 0.5779
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5779
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.4026
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1744
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.5779
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4345
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.4014
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.5779
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4252
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5779
Tuberculosis_Homo sapiens_hsa05152 SRC 0.4345
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4769
Platelet activation_Homo sapiens_hsa04611 SRC 0.5242
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.4468
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.4647
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.5733
Gap junction_Homo sapiens_hsa04540 SRC 0.5779
Insulin resistance_Homo sapiens_hsa04931 PPARA 0.5519
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4951
Measles_Homo sapiens_hsa05162 CSNK2A1 0.5068
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5733
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.4252
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5779
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5519
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.5109
Peroxisome_Homo sapiens_hsa04146 XDH 0.5779
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5242
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5709
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5759
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.5242
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.5109
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5779
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.568
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5779
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5709
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.5779
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.5299
Axon guidance_Homo sapiens_hsa04360 MET 0.5196
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5779
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6299
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5759
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5759
Glioma_Homo sapiens_hsa05214 IGF1R 0.6299
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6119
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6375
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6295
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6299
Bile secretion_Homo sapiens_hsa04976 CA2 0.6119
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.6379
Shigellosis_Homo sapiens_hsa05131 SRC 0.6299
Malaria_Homo sapiens_hsa05144 MET 0.7071
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7111
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.7091
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7131
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.8623
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.856
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8693
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.8074
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.8496
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8693
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8847
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8844
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 1.0232
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.3443
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3619


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)