TCM Prescription: Pi Min Xiao Capsules



Prescription Description
Prescription IDTCMF6949
Pinyin NamePi Min Xiao Jiao Nang
Chinese Name皮敏消胶囊
English NamePi Min Xiao Capsules
Function Description祛风除湿, 清热解毒, 凉血止痒。用于急慢性荨麻疹, 急性湿疹属风热证或风热挟湿证者。
IndicationsHeat pattern, Eczema
Disease ICD-11 Category SE72 [Heat pattern (TM1), 热证 (TM1) ];
EA8Z [Dermatitis or eczema, unspecified, 皮炎或湿疹，未特指 ];
Human Tissues Associated with IndicationSkin
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1215 Sophora flavescens 苦参 TCMH1215 ITSAM449-14
TCMH211 Atractylodes lancea 苍术 TCMH211 ITSAN4439-14
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH1141 Schizonepeta tenuifolia 荆芥 TCMH1141 ITSAL858-14
TCMH1024 Tribulus terrestris 蒺藜 TCMH1024 ITSAJ4258-14
TCMH112 Dictamnus albus 白藓皮 TCMH112 GBVK982-11
TCMH1866 Cnidium monnieri 蛇床子 TCMH1866 ITSAL2575-14
TCMH206 Fructus xanthii sibirici 苍耳子 TCMH206 KJ496390
TCMH2176 Scolopendra subspinipes mutilans 蜈蚣 TCMH2176
TCMH1678 Indigo naturalis 青黛 TCMH1678
TCMH1632 Taraxacum mongolicum 蒲公英 TCMH1632 ITSAG679-14
TCMH2711 Viola yedoensis 紫花地丁 TCMH2711
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH949 Phellodendron amurense 黄柏 TCMH949 ITSAM1586-14
TCMH972 Coptis chinensis 黄连 TCMH972 ITSAO4469-14
TCMH235 Periostracum cicadae 蝉蜕 TCMH235
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH1513 Paeonia moutan 牡丹皮 TCMH1513
TCMH2225 Cacumen tamaricis 西河柳 TCMH2225
TCMH2706 Lithospermum erythrorhizon 紫草 TCMH2706
TCMH449 Cortex lycii radicis 地骨皮 TCMH449
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT176 SOAT1 Acyl coenzyme A:cholesterol acyltransferase 1 Transferase P35610
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT263 SOAT2 Acyl coenzyme A:cholesterol acyltransferase 2 Transferase O75908
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT355 CSNK1D Casein kinase I delta Kinase P48730
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT417 DYRK2 Dual-specificity tyrosine-phosphorylation regulated kinase 2 Kinase Q92630
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT458 HASPIN Serine/threonine-protein kinase haspin Kinase Q8TF76
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT473 PIM3 Serine/threonine-protein kinase PIM3 Kinase Q86V86
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT640 CTSD Cathepsin D Unclassified P07339
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT763 DYRK3 Dual-specificity tyrosine-phosphorylation regulated kinase 3 Kinase O43781
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT814 CLK1 Dual specificty protein kinase CLK1 Kinase P49759
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT829 NISCH Nischarin Unclassified Q9Y2I1
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT831 DYRK4 Dual specificity tyrosine-phosphorylation-regulated kinase 4 Kinase Q9NR20
TCMT832 DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B Kinase Q9Y463
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HASPIN, HSD17B1, IDO1, IGF1R, KDR, KIT, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, NISCH, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SOAT1, SOAT2, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 12.8896
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, ESR1, FABP3, FABP4, FUT7, HSD17B1, KIT, MET, MIF, PPARA, PTGS2, SOAT1, SOAT2 12.5223
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FUT7, GLO1, IDO1, MIF, NISCH, PIM1, PPARA, PTGS2, SOAT1, SOAT2, XDH 11.1283
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HASPIN, HSD17B1, IDO1, IGF1R, KDR, KIT, MAOA, MET, MIF, MMP1, MMP2, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SOAT1, SOAT2, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 10.4896
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGS2 9.45377
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, FABP3, FABP4, FUT7, KIT, MET, MIF, PPARA, PTGS2, SOAT1, SOAT2 9.3795
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, ALOX15, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, KIT, MMP9, PTGS2, SRC, TERT 9.3795
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGS2 9.23757
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SOAT1, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 9.02891
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APEX1, APP, AURKB, AXL, CBR1, CDC25B, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HASPIN, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NISCH, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SOAT1, SOAT2, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 9.02891
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2 9.00747
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, HSD17B1, SOAT1, SOAT2 8.9467
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APEX1, APP, AURKB, AXL, CBR1, CDC25B, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HASPIN, HSD17B1, IDO1, IGF1R, KDR, KIT, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, NISCH, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SOAT1, SOAT2, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 8.9467
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, F3, FABP3, FABP4, FLT3, HSD17B1, KDR, KIT, MAOA, MET, MIF, NISCH, PPARA, PTGS2, SOAT1, SOAT2, SRC, TERT, TNKS, TNKS2, XDH 8.28107
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SOAT1, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 8.18893
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, IGF1R, KDR, KIT, MET, SRC 8.06559
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AKR1C3, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, DYRK3, ESR1, F3, FLT3, GLO1, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT, TOP2A, XDH 8.02228
[BP] GO:0018212 peptidyl-tyrosine modification AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, IGF1R, KDR, KIT, MET, SRC 8.02228
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AKR1C3, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, DYRK3, ESR1, F3, FLT3, GLO1, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP9, PIM1, PTGS2, PTPN1, SRC, TERT, TOP2A, XDH 8.02228
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FLT3, KDR, KIT, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 8.02228
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FLT3, KDR, KIT, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 7.99369
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK3, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GLO1, KDR, KIT, MET, MIF, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPRS, RORC, SOAT1, SOAT2, SRC, TERT, TNKS2, TOP2A 7.92298
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 7.76695
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGS2 7.74687
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, AKR1C3, APP, CDC25B, CSNK2A1, CYP1B1, DRD2, ESR1, ESRRA, F3, FABP3, FLT3, IDO1, IGF1R, KDR, KIT, MIF, MMP12, MMP2, MMP9, PIM1, PTGS2, SRC, TERT, XDH 7.42719
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MIF, MMP9, NISCH, PTGS2, SRC, TERT 7.13927
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, DYRK2, DYRK3, ESR1, ESR2, F3, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, NISCH, PTGS2, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 7.09576
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PPARA, PTGS2 7.09576
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AKR1C3, ALOX15, APP, AURKB, CDC25B, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SOAT1, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 7.09228
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, DYRK2, DYRK3, ESR1, ESR2, F3, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, NISCH, PTGS2, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 6.98306
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, IDO1, MAOA, PTGS2, XDH 6.98306
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2 6.97608
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, DYRK3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, NISCH, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 6.86915
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AKR1C3, ALOX15, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SOAT1, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 6.86078
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AKR1C3, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, DYRK3, ESR1, F3, FLT3, GLO1, IDO1, IGF1R, KDR, MIF, MMP9, PIM1, PTGS2, PTPN1, SRC, TERT, TOP2A, XDH 6.79748
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MIF, MMP9, NISCH, PTGS2, SRC, TERT 6.79707
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.77137
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CLK1, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS 6.72252
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, APEX1, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, IDO1, IGF1R, MMP2, MMP9, PPARA, PTGS2, RORC, SRC 6.68953
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, NISCH, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 6.66085
[BP] GO:0032787 None AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, IDO1, MIF, PPARA, PTGS2 6.66085
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, DYRK3, GLO1, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT 6.64101
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, APEX1, APP, AURKB, AXL, CDC25B, CLK1, CSNK2A1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIM1, PTGS2, PTPN1, PTPRS, SRC, TNKS, XDH 6.59101
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SOAT1, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 6.53007
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX15, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, MAOA, SOAT1, SOAT2 6.53007
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, DYRK3, GLO1, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP9, PIM1, PTGS2, PTPN1, SRC, TERT 6.49384
[BP] GO:0010033 response to organic substance AKR1B1, AKR1C3, ALOX15, APEX1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, IDO1, IGF1R, KDR, KIT, MMP2, PPARA, PTGS2, RORC, SRC 6.43841
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DYRK1A, DYRK1B, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SOAT1, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 6.40351
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MIF, MMP9, NISCH, PTGS2, SRC, TERT 6.33409
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MIF, MMP9, NISCH, PTGS2, SRC, TERT 6.31643
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, IDO1, IGF1R, KDR, KIT, MMP2, MMP9, PPARA, PTGS2, RORC, SRC, TERT 6.29985
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, APEX1, APP, AURKB, AXL, CDC25B, CLK1, CSNK2A1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIM1, PTGS2, PTPN1, PTPRS, SRC, TNKS, XDH 6.19836
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, DYRK2, DYRK3, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP2, MMP9, PPARA, PTGS2, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 6.19013
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD1, DRD2, IDO1, MAOA 6.19013
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AXL, CSNK2A1, CYP1B1, DRD2, F3, FLT3, KDR, KIT, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.15131
[BP] GO:0014070 response to organic cyclic compound AKR1C3, APEX1, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FLT3, PTGS2, RORC, SRC 6.05928
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DYRK1A, DYRK2, DYRK3, ESR1, F3, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 5.98228
[BP] GO:0010038 response to metal ion AKR1C3, ALOX15, APP, CA2, CYP1A1, CYP1A2, DRD2, FABP4, KIT, MMP9, PTGS2, TERT 5.88075
[BP] GO:0046777 protein autophosphorylation AURKB, CLK1, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, PIM1, SRC 5.81762
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.80501
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CYP19A1, DRD2, DYRK1A, DYRK3, ESR1, F3, FABP4, IDO1, IGF1R, MET, MIF, MMP12, MMP2, PPARA, PTGS2, PTPN1, PTPRS, SRC, TERT, XDH 5.75387
[BP] GO:0009719 response to endogenous stimulus AKR1B1, AKR1C3, APEX1, APP, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, ESRRA, FABP3, FLT3, IGF1R, KIT, MMP2, PPARA, PTGS2, SRC 5.72167
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AXL, CSNK2A1, CYP1B1, DRD2, ESRRA, F3, FABP4, FLT3, IDO1, KDR, KIT, MET, MIF, MMP12, MMP2, MMP9, PTGS2, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 5.71165
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CLK1, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, SRC, TNKS, TOP2A 5.70145
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AKR1C3, CDC25B, CSNK2A1, DRD2, ESR1, F3, FLT3, IGF1R, KDR, KIT, MIF, MMP12, MMP2, MMP9, PIM1, PTGS2, TERT 5.65814
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1 5.56117
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CLK1, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS 5.40878
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.39804
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK2, F3, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, NISCH, PPARA, PTGS2, PTPN1, SRC, TERT 5.17062
[BP] GO:0048869 cellular developmental process ACHE, AKR1C3, APP, AXL, CBR1, CDC25B, CYP1A1, DRD1, DRD2, DYRK3, ESR1, ESRRB, FABP4, FLT3, FUT7, GLO1, KDR, KIT, MET, MIF, MMP2, MMP9, PTGS2, PTPRS, RORC, SOAT1, SOAT2, SRC, TERT, TOP2A 5.17062
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, DYRK3, GLO1, IDO1, IGF1R, KDR, MIF, MMP9, PIM1, PTGS2, PTPN1, SRC, TERT 5.11947
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AXL, CYP1B1, DRD2, F3, FLT3, KDR, KIT, MET, MIF, PTGS2, PTPN1, SRC, XDH 5.06685
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, AOX1, APP, AURKB, AXL, CDC25B, CLK1, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, F3, FLT3, FUT7, GLO1, HASPIN, IDO1, IGF1R, KDR, KIT, MAOA, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, TOP2A, XDH 5.06685
[BP] GO:0009725 response to hormone AKR1B1, AKR1C3, APEX1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, KIT, PPARA, PTGS2, SRC 5.04494
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AKR1C3, ALOX15, APEX1, APP, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PTGS2, RORC, SRC, TERT 5.01828
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1 4.98043
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, DRD1, DRD2, DYRK1B, DYRK2, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, PPARA, PTGS2, RORC, SOAT1, SRC, TERT, TNKS, TNKS2, TOP2A 4.82498
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HASPIN, HSD17B1, IDO1, IGF1R, KDR, KIT, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, NISCH, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SOAT1, SOAT2, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, XDH 4.82457
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DYRK1A, DYRK2, DYRK3, ESR1, ESR2, F3, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 4.82457
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AKR1C3, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, IDO1, MAOA, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.72419
[BP] GO:0051716 cellular response to stimulus AKR1B1, AKR1C3, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DYRK2, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MIF, MMP2, MMP9, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A 4.64413
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, HASPIN, TERT, TNKS, TNKS2 4.6245
[BP] GO:0033993 response to lipid AKR1C3, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, IDO1, PTGS2, RORC, SRC 4.58883
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, APEX1, APP, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, PTGS2, RORC, SRC 4.58497
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2, NISCH 4.52083
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, DYRK1A, ESR1, KIT, PPARA, RORC, SRC, TOP2A 4.47263
[BP] GO:0071310 cellular response to organic substance AKR1B1, AKR1C3, ALOX15, APEX1, APP, AXL, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, PTGS2, RORC, SRC 4.42113
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, CYP19A1, DRD1, DRD2, DYRK1A, DYRK3, ESR1, ESR2, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTGS2, PTPN1, PTPRS, SRC, TERT, XDH 4.41031
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, IDO1, MIF, PIM1, PPARA, PTGS2 4.41031
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, MMP9, SRC 4.37726
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, DRD1, DRD2, DYRK1B, DYRK2, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MET, MMP12, PPARA, PTGS2, RORC, SOAT1, SRC, TERT, TNKS, TNKS2, TOP2A 4.37603
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APP, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRB, F3, FABP4, IDO1, IGF1R, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, SOAT1, SOAT2, SRC, TNKS2 4.27772
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, DRD1, DRD2, KIT, NISCH, PTGS2 4.27772
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, DRD1, DRD2, KIT, NISCH, PTGS2 4.27772
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1, GLO1, IDO1 4.2731
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, DRD1, DRD2, KDR, MIF, PTGS2, SRC, TNKS, TNKS2 4.22398
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, ESR1, F3, FABP4, IDO1, KDR, MET, MIF, MMP12, PPARA, PTGS2, PTPRS 4.19249
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 4.11944
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, DRD1, DRD2, DYRK1A, DYRK3, ESR1, ESR2, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SRC, TERT, XDH 4.11785
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, DRD1, DRD2, DYRK1A, DYRK3, ESR1, ESR2, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SRC, TERT, XDH 4.10043
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1, DRD2, PTGS2 4.08255
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, AKR1C3, CSNK2A1, DRD1, DRD2, MAOA 4.0026
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA 3.91859
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, IDO1, MIF, PIM1, PPARA, PTGS2 3.89468
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.88967
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, AKR1C3, ALOX15, APEX1, APP, AURKB, CA9, CDC25B, CLK1, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SOAT1, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.87813
[BP] GO:1902532 negative regulation of intracellular signal transduction DRD2, DYRK1A, DYRK3, ESR1, IGF1R, MET, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 3.87813
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, AKR1C3, ALOX15, APEX1, APP, AURKB, CA9, CDC25B, CLK1, CSNK2A1, CYP1B1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SOAT1, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.80842
[BP] GO:0006082 organic acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, IDO1, MIF, PIM1, PPARA, PTGS2 3.80842
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, APP, AXL, CA12, CA2, CA7, DRD1, DRD2, ESR1, FABP3, FABP4, FLT3, MET, SOAT1, SOAT2, SRC, TERT 3.7751
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, CDC25B, DRD1, DRD2, ESRRB, FABP3, FLT3, KDR, KIT, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 3.75387
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, CDC25B, DRD1, DRD2, ESRRB, FABP3, FLT3, KDR, KIT, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 3.75387
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 3.75387
[BP] GO:0030335 positive regulation of cell migration APP, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 3.71955
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AURKB, DRD2, DYRK1B, DYRK2, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MET, MMP12, PPARA, RORC, SOAT1, SRC, TERT, TNKS, TNKS2, TOP2A 3.71461
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APEX1, APP, AXL, CYP1B1, DRD1, ESR1, IGF1R, MMP2, MMP9, PTGS2, RORC, SRC 3.69276
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, AKR1C3, ALOX15, APEX1, APP, AURKB, CA9, CDC25B, CLK1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SOAT1, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.66119
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, AKR1C3, CYP1A1, FABP3, FLT3, KIT, PPARA, PTGS2, RORC, SRC 3.62545
[BP] GO:2000147 positive regulation of cell motility APP, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 3.58349
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, DRD2, F3, KIT, MET, SRC, XDH 3.57988
[BP] GO:0071248 cellular response to metal ion AKR1C3, ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.55928
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.55577
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.55577
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK2, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, IDO1, IGF1R, KDR, KIT, MIF, MMP12, MMP2, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A 3.50809
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HASPIN, HSD17B1, IDO1, IGF1R, KDR, KIT, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, NISCH, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SOAT1, SOAT2, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.48471
[BP] GO:0051272 positive regulation of cellular component movement APP, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 3.48471
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DRD2, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 3.45442
[BP] GO:0046686 response to cadmium ion AKR1C3, CYP1A2, KIT, MMP9, TERT 3.43374
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, DYRK1B, ESR1, ESRRA, ESRRB, FLT3, KDR, KIT, MMP9, PIM1, PPARA, PTGS2, PTPRS, RORC, SRC 3.38629
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, PTGS2, TNKS, TNKS2 3.38629
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.38093
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.38093
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.38093
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, KDR, KIT, PPARA, PTPRS, SRC 3.37522
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, CA9, CDC25B, CLK1, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SOAT1, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.368
[BP] GO:0040017 positive regulation of locomotion APP, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 3.3645
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP3A4 3.28631
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, CYP3A4, HSD17B1 3.28007
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.26606
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.23242
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, CDC25B, DRD1, DRD2, ESRRB, FABP4, FLT3, IGF1R, KDR, KIT, MIF, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 3.22644
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, ESR1, HSD17B1 3.21373
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, DRD2, FLT3, KDR, KIT, MIF, PTPN1, SRC, XDH 3.19986
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.1972
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, PTGS2 3.1972
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, MMP9, SRC 3.16701
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, RORC 3.15462
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, DRD1, DRD2, FABP3, KDR, PTGS2, SRC 3.15257
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.10359
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.10359
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, CDC25B, DRD2, ESRRB, FLT3, KDR, KIT, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 3.10044
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK2, IDO1, KIT, MIF, MMP2, MMP9, PPARA, PTGS2, PTPN1, SRC, TERT, TOP2A 3.09081
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, AOX1, APEX1, APP, AURKB, AXL, CDC25B, CLK1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, FUT7, GLO1, HASPIN, IDO1, IGF1R, KDR, KIT, MAOA, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.07293
[BP] GO:0010907 None DYRK2, ESRRB, PPARA, SRC 3.02549
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APEX1, APP, AXL, CYP1B1, MMP9, PTGS2, SRC 3.02411
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SRC, TERT 3.02332
[BP] GO:0044283 None AKR1B1, AKR1C3, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, IDO1, MIF, PTGS2 3.00518
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, DRD1, DRD2, DYRK1B, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MET, MMP12, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TOP2A 3.00207
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, PTGS2, SRC 2.99696
[BP] GO:0019371 None AKR1C3, CBR1, PTGS2 2.99209
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA 2.98159
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, CLK1, CYP1A1, ESR1, FLT3, KIT, MET, MIF, PIM1, SRC 2.97882
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, CA9, CDC25B, CLK1, CSNK2A1, CYP1B1, DRD1, DRD2, DYRK1A, DYRK1B, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SOAT1, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.97377
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD2, MIF, NISCH 2.97377
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.97109
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, CDC25B, DRD1, DRD2, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MIF, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 2.96087
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SRC, TERT 2.95609
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD17B1, MIF, PTGS2 2.93853
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, CDC25B, DRD1, DRD2, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MIF, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 2.9171
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, MMP9, SRC 2.9171
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.89595
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, ESR1, FABP4, IDO1, MMP12, MMP2, PPARA, PTGS2, PTPN1, PTPRS, SRC 2.89595
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2, TERT 2.89595
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, MIF, PTGS2 2.86967
[BP] GO:0006066 None AKR1B1, AKR1B10, AKR1C3, APP, CYP1B1, CYP3A4, SOAT1, SOAT2 2.86749
[BP] GO:0009968 negative regulation of signal transduction DRD2, DYRK1A, DYRK3, ESR1, ESR2, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SRC, TERT, XDH 2.85572
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, CDC25B, CSNK2A1, DRD2, DYRK1A, ESR1, F3, FLT3, KDR, KIT, MIF, MMP9, PTGS2, PTPN1, SOAT1, SRC, XDH 2.85572
[BP] GO:0018107 peptidyl-threonine phosphorylation CLK1, CSNK2A1, DYRK1A, HASPIN, TNKS 2.85572
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AKR1C3, APEX1, APP, AURKB, CSNK2A1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, FABP4, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.85572
[BP] GO:2000146 None ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD2, MIF, NISCH 2.85572
[BP] GO:0016488 None AKR1B10, AKR1C3 2.85572
[BP] GO:0016487 None AKR1B10, AKR1C3 2.85572
[BP] GO:0016107 None AKR1B10, AKR1C3 2.85572
[BP] GO:0009115 None AOX1, XDH 2.85572
[BP] GO:0006714 None AKR1B10, AKR1C3 2.85572
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AKR1C3, APEX1, APP, DRD1, ESR1, FLT3, IGF1R, KIT, MMP2, PTGS2, SRC 2.85565
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, DRD1, KDR, PTGS2, SRC 2.83961
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DRD2, MIF, SRC, TERT 2.83961
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC, TERT 2.81381
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7, MIF 2.78237
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, KDR, SRC 2.7766
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, APP, AXL, CDC25B, CYP19A1, CYP1A1, DRD1, ESR1, ESRRB, IDO1, KIT, MMP2, MMP9, PTGS2, SRC, TOP2A 2.76601
[BP] GO:0001816 cytokine production APP, FABP4, IDO1, KIT, PTGS2 2.76363
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, CDC25B, DRD2, FLT3, KDR, KIT, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 2.76348
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SRC, TERT 2.75618
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.74511
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.74497
[BP] GO:0043518 None DYRK1A, DYRK3, MIF 2.74497
[BP] GO:0018210 peptidyl-threonine modification CLK1, CSNK2A1, DYRK1A, HASPIN, TNKS 2.72515
[BP] GO:0051271 None ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD2, MIF, NISCH 2.71509
[BP] GO:0032845 None ADORA1, DRD2, MIF, SRC, TNKS, TNKS2 2.71007
[BP] GO:0044259 multicellular organismal macromolecule metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.70872
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, CA2, CYP19A1, DRD1, DRD2, MIF, MMP12, PTGS2, SRC, TERT 2.69797
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, CDC25B, DRD1, DRD2, FABP4, FLT3, IGF1R, KDR, KIT, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 2.69741
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, MAOA 2.68841
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, MAOA 2.68841
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.68841
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, DRD2, FLT3, IGF1R, KDR, KIT, MIF, PTPN1, SRC, XDH 2.68692
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, CA2, CYP1B1, DRD2, ESRRB, F3, IDO1, KDR, KIT, MET, MIF, MMP12, MMP9, PIM1, PTGS2, SRC, TERT 2.68186
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.67367
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 2.65343
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ALOX15, APP, AXL, CA2, CA7, CYP19A1, DRD1, DRD2, DYRK2, MIF, MMP12, MMP9, PPARA, PTGS2, PTPN1, SRC, TERT 2.6431
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, DRD1, DRD2, KDR, SRC 2.61515
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AKR1C3, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, IDO1, MAOA, XDH 2.61492
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, F3, KIT, MET, SRC 2.60211
[BP] GO:0031324 negative regulation of cellular metabolic process AKR1C3, APEX1, APP, AURKB, CSNK2A1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, FABP4, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.60211
[BP] GO:0040013 None ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD2, MIF, NISCH 2.60211
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.60025
[BP] GO:0032225 None DRD1, DRD2, PTGS2 2.60025
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.60025
[BP] GO:0002683 negative regulation of immune system process ADORA1, ALOX15, AXL, CYP19A1, DRD2, IDO1, MIF, MMP12, PTPRS 2.59392
[BP] GO:0048167 None ADORA1, APP, DRD1, DRD2, KIT, PTGS2 2.5804
[BP] GO:2000107 negative regulation of leukocyte apoptotic process AURKB, AXL, IDO1, MIF 2.55852
[BP] GO:0050730 None ADORA1, APP, FLT3, KIT, MIF, PTPN1, SRC 2.54769
[BP] GO:0019538 protein metabolic process ACHE, APP, AURKB, AXL, CDC25B, CLK1, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, F3, FLT3, FUT7, HASPIN, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, SRC, TNKS, TNKS2, TOP2A 2.54769
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, DRD1, DRD2, KIT, MMP2, PPARA, PTGS2, SRC, TERT 2.54169
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway MIF, MMP9, PTGS2, PTPN1, SRC 2.54026
[BP] GO:0008542 None APP, DRD1, DRD2, KIT 2.53068
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.53068
[BP] GO:0010906 None DYRK2, ESRRB, PPARA, RORC, SRC 2.52282
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, APP, AURKB, CDC25B, DRD2, ESR1, ESR2, F3, FLT3, KIT, MET, MIF, MMP9, PTPN1, SRC, TERT, TNKS, XDH 2.51638
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.50225
[BP] GO:0042752 None ADORA1, DRD2, PPARA, RORC, TOP2A 2.48417
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DRD1, DRD2, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC 2.48068
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 2.48051
[BP] GO:0034435 None SOAT1, SOAT2 2.48051
[BP] GO:0034433 None SOAT1, SOAT2 2.48051
[BP] GO:0034434 None SOAT1, SOAT2 2.48051
[BP] GO:0046110 None AOX1, XDH 2.48051
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.48051
[BP] GO:0016095 None AKR1B10, AKR1C3 2.48051
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3 2.47576
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, CLK1, DRD1, DYRK1A, SRC, TNKS 2.44903
[BP] GO:0080135 regulation of cellular response to stress APP, DYRK1A, DYRK3, IGF1R, MET, MIF, PTGS2, PTPN1, PTPRS, TERT, XDH 2.449
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, DRD2, ESR1, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.43703
[BP] GO:0010676 None DYRK2, ESRRB, PPARA, SRC 2.42277
[BP] GO:0007632 None APP, DRD1, DRD2, KIT 2.39275
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.39275
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, APP, AURKB, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F3, FABP4, FLT3, IGF1R, KIT, MET, MIF, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT, TNKS, XDH 2.38132
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, F3, FABP4, FLT3, IGF1R, KIT, MIF, MMP9, PTGS2, PTPN1, SRC, TERT, TNKS, XDH 2.36588
[BP] GO:0044236 multicellular organism metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.35202
[BP] GO:0030154 cell differentiation AKR1C3, AXL, CBR1, CYP1A1, DYRK3, ESR1, FABP4, FLT3, FUT7, GLO1, KDR, KIT, MMP2, MMP9, PTGS2, RORC, SOAT1, SOAT2, TOP2A 2.35172
[BP] GO:0051098 regulation of binding APP, AURKB, MET, MMP9, PPARA, SRC, TERT, TNKS 2.35111
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, KIT, MIF, PTPN1, SRC 2.35111
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, KDR, KIT, PTGS2, TERT 2.32612
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.32274
[BP] GO:1901796 None AURKB, CSNK2A1, DYRK1A, DYRK2, DYRK3, MIF 2.31622
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HASPIN, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NISCH, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SOAT1, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.31622
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, IGF1R, PPARA, PTGS2, SRC 2.30814
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, CDC25B, DRD2, DYRK1A, FLT3, KDR, KIT, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 2.3072
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.29761
[BP] GO:0009889 regulation of biosynthetic process ADORA3, AKR1C3, APEX1, APP, AURKB, CA9, CSNK2A1, CYP1B1, DRD1, DRD2, DYRK1B, DYRK2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, IGF1R, KDR, KIT, MET, MMP12, PIM1, PPARA, PTGS2, RORC, SOAT1, SRC, TERT, TNKS, TNKS2, TOP2A 2.29761
[BP] GO:1901361 None AOX1, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP3A4, IDO1, MAOA, XDH 2.28821
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, DRD2, DYRK2, F3, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2 2.28821
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, DRD2, PPARA 2.28625
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, CA2, CYP1B1, DRD2, ESR1, ESRRA, ESRRB, F3, IDO1, KDR, KIT, MET, MIF, MMP12, MMP9, PIM1, PTGS2, PTPRS, SRC, TERT, TNKS2, XDH 2.28269
[BP] GO:0002521 leukocyte differentiation AXL, FLT3, FUT7, GLO1, KIT, MMP9, RORC 2.28099
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, CA12, CA2, CA7, DRD1, DRD2, ESR1, FABP3, FABP4, MET, SOAT1, SOAT2 2.25635
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.24758
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.24758
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, CA2, CYP19A1, DRD2, ESR1, ESRRA, IDO1, KIT, MIF, MMP12, MMP2, PTPN1, PTPRS, SRC 2.24586
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, PTGS2 2.24584
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4 2.24584
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, CDC25B, DRD2, DYRK1A, ESR1, F3, FLT3, KDR, KIT, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 2.2421
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP3A4, MAOA 2.2421
[BP] GO:0018209 peptidyl-serine modification AURKB, CLK1, DRD1, DYRK1A, SRC, TNKS 2.2421
[BP] GO:0070213 None TNKS, TNKS2 2.2421
[BP] GO:0006145 None AOX1, XDH 2.2421
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.2421
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.2421
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DRD1, DRD2, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC 2.23765
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AKR1C3, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, IDO1, MAOA, SRC, XDH 2.23691
[BP] GO:0051172 None APEX1, APP, AURKB, CSNK2A1, DRD2, DYRK1A, ESR1, ESR2, ESRRA, FABP4, IGF1R, MIF, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.23691
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.23567
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AXL, CA1, CA2, CSNK2A1, CYP1B1, DRD1, DRD2, DYRK2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, MIF, MMP2, MMP9, NISCH, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2 2.22616
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HASPIN, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NISCH, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SOAT1, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.22517
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.2152
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.21351
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, MET 2.19169
[BP] GO:0090068 positive regulation of cell cycle process APEX1, APP, AURKB, CDC25B, CYP1A1, DRD2, TERT 2.18743
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, KDR, MIF, PTPN1, SRC 2.18743
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, FUT7, KDR, KIT, MIF, MMP1, MMP12, MMP9, SRC 2.18518
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.17023
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.17023
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.16544
[BP] GO:0010675 None DYRK2, ESRRB, PPARA, RORC, SRC 2.14961
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, MIF, PPARA, PTPRS 2.14831
[BP] GO:0032103 positive regulation of response to external stimulus F3, FABP4, IDO1, KDR, MET, MIF, PTGS2 2.14831
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.14831
[BP] GO:0044267 cellular protein metabolic process APP, AURKB, AXL, CDC25B, CLK1, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, FLT3, FUT7, HASPIN, IGF1R, KDR, KIT, MET, MMP1, MMP2, PIM1, PTPN1, PTPRS, SRC, TNKS, TNKS2, TOP2A 2.1416
[BP] GO:0006464 cellular protein modification process APP, AURKB, AXL, CDC25B, CLK1, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, FLT3, FUT7, HASPIN, IGF1R, KDR, KIT, MET, PIM1, PTPN1, PTPRS, SRC, TNKS, TNKS2, TOP2A 2.13148
[BP] GO:0036211 protein modification process APP, AURKB, AXL, CDC25B, CLK1, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, FLT3, FUT7, HASPIN, IGF1R, KDR, KIT, MET, PIM1, PTPN1, PTPRS, SRC, TNKS, TNKS2, TOP2A 2.13148
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.12855
[BP] GO:0006081 None AKR1B10, AKR1C3, CYP1B1, GLO1 2.12855
[BP] GO:0048169 None APP, DRD2, KIT 2.12855
[BP] GO:0051179 None ABCB1, ACHE, ADORA1, AKR1C3, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD1, DRD2, ESR1, FABP3, HASPIN, KIT, MIF, MMP12, MMP9, NISCH, PPARA, SOAT1, SOAT2, SRC, TERT, TNKS, TNKS2, XDH 2.12756
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, KDR, MIF, SRC 2.11782
[BP] GO:0042632 None FABP3, FABP4, SOAT1, SOAT2 2.1075
[BP] GO:0055092 None FABP3, FABP4, SOAT1, SOAT2 2.1075
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.09906
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, APP, CA2, CA7, DRD1, DRD2, MIF, MMP9, PTGS2 2.08988
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CYP19A1, CYP3A4, HSD17B1 2.08988
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.08988
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.08988
[BP] GO:0006693 None AKR1C3, MIF, PTGS2 2.08988
[BP] GO:0006692 None AKR1C3, MIF, PTGS2 2.08988
[BP] GO:0021853 None DRD1, DRD2 2.07738
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1 2.07738
[BP] GO:0010641 None F3, SRC 2.07738
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.07738
[BP] GO:1904936 None DRD1, DRD2 2.07738
[BP] GO:0042321 None ADORA1, DRD2 2.07738
[BP] GO:0045913 None DYRK2, ESRRB, PPARA, SRC 2.07563
[BP] GO:0016125 None APP, CYP19A1, CYP1B1, SOAT1, SOAT2 2.07142
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2, TERT 2.07142
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.05396
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, CDC25B, DRD1, DRD2, DYRK1A, FABP4, FLT3, IGF1R, KDR, KIT, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 2.0532
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.05088
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SRC, XDH 2.04046
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DRD1, IGF1R, MMP2, PTGS2, SRC 2.03732
[BP] GO:1901992 positive regulation of mitotic cell cycle phase transition APEX1, APP, CYP1A1, TERT 2.03732
[BP] GO:0007416 None ACHE, APP, DRD1, DRD2 2.03732
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DRD2, FABP4, FLT3, IGF1R, KIT, MIF, PTPN1, SRC, TNKS 2.0331
[BP] GO:0008306 None APP, DRD1, DRD2, KIT 2.01852
[BP] GO:0016572 histone phosphorylation AURKB, DRD1, HASPIN 2.01852
[BP] GO:0042417 None DRD1, DRD2, MAOA 2.01852
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.01852
[BP] GO:0050793 regulation of developmental process APP, AXL, CA2, CYP1B1, DRD2, ESR1, ESRRA, ESRRB, F3, IDO1, KDR, KIT, MIF, PIM1, PPARA, PTGS2, PTPRS, RORC, SRC, TERT, TNKS2, XDH 2.01756
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, CDC25B, CSNK2A1, CYP1A1, DRD2, MIF, PIM1, PTGS2, SRC, TERT, TNKS, TOP2A 2.00613
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, FUT7, KDR, KIT, MET, MIF, MMP1, MMP12, MMP9, SRC 2.00272
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.00025
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, AOX1, APEX1, APP, AURKB, AXL, CA1, CA2, CA4, CBR1, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HASPIN, IGF1R, KDR, KIT, MAOA, MIF, MMP12, MMP2, MMP9, NISCH, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SOAT1, SOAT2, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, XDH 5.17062
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, AOX1, APEX1, APP, AURKB, AXL, CA1, CA2, CA4, CA9, CBR1, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HASPIN, IDO1, IGF1R, KDR, KIT, MAOA, MIF, MMP12, MMP2, MMP9, NISCH, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SOAT1, SOAT2, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, XDH 5.01245
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APEX1, APP, AURKB, CA1, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, DYRK2, DYRK3, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, IDO1, KDR, KIT, MAOA, MIF, MMP2, MMP9, NISCH, PIM1, PTGS2, PTPN1, PTPRS, SOAT1, SOAT2, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.00271
[CC] GO:0043231 intracellular membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, APEX1, APP, AURKB, CA4, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, FUT7, GLO1, HASPIN, IGF1R, KDR, KIT, MAOA, MMP12, MMP2, PIM1, PPARA, PTGS2, PTPN1, RORC, SOAT1, SOAT2, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, XDH 2.7752
[CC] GO:0043229 intracellular organelle ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, APEX1, APP, AURKB, CA4, CA9, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, FUT7, GLO1, HASPIN, IDO1, IGF1R, KDR, KIT, MAOA, MMP12, MMP2, NISCH, PIM1, PPARA, PTGS2, PTPN1, RORC, SOAT1, SOAT2, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, XDH 2.4662
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HASPIN, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SOAT1, SOAT2, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, XDH 18.6947
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DYRK2, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TNKS, XDH 16.8465
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DYRK1A, DYRK1B, DYRK2, DYRK3, F3, FLT3, FUT7, GLO1, HASPIN, HSD17B1, IDO1, IGF1R, KDR, KIT, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS2, PTPN1, PTPRS, SOAT1, SOAT2, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, XDH 16.8182
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.68506
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, GLO1, IDO1, KIT, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, TERT, TNKS, TNKS2, TOP2A, XDH 9.02891
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, IDO1, MAOA, PTGS2, XDH 8.23878
[MF] GO:0004713 protein tyrosine kinase activity AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, IGF1R, KDR, KIT, MET, SRC 8.16746
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 8.14933
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIM1, PPARA, SRC, TOP2A 7.63414
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH 7.63414
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, GLO1, IDO1, KIT, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, TERT, TNKS, TNKS2, TOP2A, XDH 7.63414
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, RORC, SOAT1, SOAT2 7.46694
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, IDO1, PTGS2, SRC 7.30642
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, IDO1, PTGS2, SRC 7.03555
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, TNKS 6.86915
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 6.86078
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.64902
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, IDO1, PTGS2, SOAT1, SOAT2, SRC, XDH 6.63348
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.19013
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 5.94212
[MF] GO:0004672 protein kinase activity AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIM1, SRC 5.86246
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD17B1, NISCH, PPARA, RORC, SOAT1, SOAT2 5.68689
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PTGS2 5.56257
[MF] GO:0043168 anion binding ABCB1, ALOX15, AOX1, APP, AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, F3, FABP3, FABP4, FLT3, HASPIN, HSD17B1, IGF1R, KDR, KIT, MET, NISCH, PIM1, PTPRS, SOAT1, SOAT2, SRC, TOP2A, TUBB3, XDH 5.43352
[MF] GO:0004712 protein serine/threonine/tyrosine kinase activity AURKB, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3 5.43352
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 5.26063
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.06685
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.06685
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 4.99663
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIM1, SRC 4.8825
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.6245
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.50853
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, AOX1, APEX1, APP, AURKB, AXL, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, FLT3, HASPIN, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP12, PIM1, PPARA, PTGS2, PTPN1, RORC, SOAT1, SOAT2, SRC, TERT, TOP2A, TUBB3, XDH 4.45821
[MF] GO:0016301 kinase activity AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIM1, SRC 4.41347
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 4.41031
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AOX1, AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FABP3, FABP4, FLT3, HASPIN, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SOAT1, SOAT2, SRC, TOP2A, TUBB3, XDH 4.25364
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIM1, SRC, TERT 4.21358
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 3.95325
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, AOX1, XDH 3.89468
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, AOX1, CBR1, HSD17B1, XDH 3.77506
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, IDO1, PTGS2 3.38629
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, IDO1, PTGS2 3.3352
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, CSNK2A1, DRD2, DYRK1A, ESR1, ESR2, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP9, NISCH, PTGS2, TERT, TOP2A, XDH 3.31188
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 3.2676
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.23242
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, NISCH, PIM1, PPARA, PTPN1, SRC 3.10437
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, F3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, PTPRS, SRC 3.01138
[MF] GO:1901363 heterocyclic compound binding ABCB1, ADORA1, AOX1, APEX1, APP, AURKB, AXL, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, FLT3, HASPIN, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP12, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TOP2A, TUBB3, XDH 2.97377
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, NISCH, PPARA, PTPN1, SRC 2.8669
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP2A 2.85572
[MF] GO:0000166 nucleotide binding ABCB1, AOX1, AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP2A, TUBB3, XDH 2.85572
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AOX1, AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP2A, TUBB3, XDH 2.85572
[MF] GO:0034736 None SOAT1, SOAT2 2.85572
[MF] GO:0045550 None AKR1B10, AKR1C3 2.85572
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.85572
[MF] GO:0004772 None SOAT1, SOAT2 2.85572
[MF] GO:0008389 None CYP2A13, CYP2A6 2.85572
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP2A 2.75332
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP2A 2.72323
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, PPARA, RORC 2.71509
[MF] GO:0097367 carbohydrate derivative binding ABCB1, ADORA1, APP, AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIM1, PTPRS, SRC, TOP2A, TUBB3 2.68841
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.48051
[MF] GO:0047718 None AKR1B10, AKR1C3 2.48051
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.48051
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.35111
[MF] GO:0035639 purine ribonucleoside triphosphate binding ABCB1, AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP2A, TUBB3 2.34087
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, HASPIN, PIM1 2.2942
[MF] GO:0032555 purine ribonucleotide binding ABCB1, AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP2A, TUBB3 2.2421
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.2421
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.2421
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.2421
[MF] GO:0017076 purine nucleotide binding ABCB1, AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP2A, TUBB3 2.2152
[MF] GO:0032553 ribonucleotide binding ABCB1, AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP2A, TUBB3 2.20889
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, PPARA, RORC 2.19575
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, CBR1, HSD17B1 2.17909
[MF] GO:0004033 None AKR1B1, AKR1B10, AKR1C3 2.08988
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.07738
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.07738
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, KIT, MET, PPARA, RORC 2.07352
[MF] GO:0016740 transferase activity AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, FUT7, HASPIN, IGF1R, KDR, KIT, MET, PIM1, SOAT1, SOAT2, SRC, TERT, TNKS, TNKS2 2.03372


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, CYP1A1, AKR1C3, CYP1B1, PTGS2, CYP19A1, IGF1R 8.9602
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.6015
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 7.3568
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 6.5874
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, CYP1A2, CYP1A1, AKR1C3, CYP1B1, CYP3A4, CYP19A1 7.0691
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.5312
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MAOA, ALOX15, AKR1C3, AKR1B1, PTGS2, CYP3A4, CYP19A1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, CYP1A2, CYP1A1, AOX1, XDH, IDO1 4.8586
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, AKR1C3, PTGS2 4.2015
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 3.8474
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 4.1451
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP1A2, AOX1, CYP3A4 4.058
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.9458
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 3.4279
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, KIT, PTGS2, MMP9, MET, IGF1R 2.9658
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAOA, ALOX5, ALOX15, PTGS2 3.1997
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.7338
MicroRNAs in cancer_Homo sapiens_hsa05206 ABCB1, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 2.9658
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KIT, KDR, DRD2, MET, IGF1R 2.942
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.9658
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3, DRD1, DRD2 2.6467
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 1.8745
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, PTGS2 2.1505
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.1445
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.0752
Cocaine addiction_Homo sapiens_hsa05030 MAOA, DRD1, DRD2 2.3024
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET 1.988
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.9404
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.3652
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, MIF 2.6796
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.6981
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1, F3 1.6012
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, DRD1, DRD2, PPARA 1.5919
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, CYP3A4 1.9404
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.5802
Ras signaling pathway_Homo sapiens_hsa04014 KIT, KDR, MET, IGF1R 1.4278
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 2.9052
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.2242
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, DRD1, DRD2 1.3652
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, DRD1, DRD2 1.1807
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KIT, KDR, MET, IGF1R 0.957
Alcoholism_Homo sapiens_hsa05034 MAOA, DRD1, DRD2 1.067
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.9278
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.8854
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.0752
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, DRD1 1.1042
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.8119
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 0.8119
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.9278
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.9622
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 0.9385
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0171
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.7729
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.1011
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 0.9183
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7729
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.1807
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.7673
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.6824
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.6784
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.6824
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.6853
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.6474
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2 0.6474
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.6196
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.1988
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.1988
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.2425
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.2526
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2515
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2771
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.272
Calcium signaling pathway_Homo sapiens_hsa04020 DRD1 0.2769
Tuberculosis_Homo sapiens_hsa05152 SRC 0.277
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.288
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.272
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.315
Phagosome_Homo sapiens_hsa04145 TUBB3 0.312
Measles_Homo sapiens_hsa05162 CSNK2A1 0.3353
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.328
Phospholipase D signaling pathway_Homo sapiens_hsa04072 KIT 0.3269
Platelet activation_Homo sapiens_hsa04611 SRC 0.352
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3316
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.3391
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3391
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.352
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.352
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.352
Axon guidance_Homo sapiens_hsa04360 MET 0.3476
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.3716
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.3543
Melanogenesis_Homo sapiens_hsa04916 KIT 0.3973
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.3942
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3973
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.3973
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.3998
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4111
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.4111
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.3998
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.3973
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.3998
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4111
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4111
Small cell lung cancer_Homo sapiens_hsa05222 PTGS2 0.4111
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4111
Peroxisome_Homo sapiens_hsa04146 XDH 0.4154
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4494
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4293
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.45
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4614
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.4804
Glioma_Homo sapiens_hsa05214 IGF1R 0.4804
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4793
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.4804
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.4876
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6486
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.4804
Shigellosis_Homo sapiens_hsa05131 SRC 0.4804
Legionellosis_Homo sapiens_hsa05134 CLK1 0.5164
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.5164
Malaria_Homo sapiens_hsa05144 MET 0.5467
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6054
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.5438
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5528
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5498
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5493
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.5738
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6066
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.6442
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8523
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6066
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6708
Base excision repair_Homo sapiens_hsa03410 APEX1 0.6511
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.6803
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.6936
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA, MIF 2.0338
Steroid biosynthesis_Homo sapiens_hsa00100 SOAT1, SOAT2 1.9404
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.6784
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.6853
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.7199
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.1756


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)