TCM Prescription: Xiao Er Ke Chuan Ling Granules



Prescription Description
Prescription IDTCMF6943
Pinyin NameXiao Er Ke Chuan Ling Ke Li
Chinese Name小儿咳喘灵颗粒
English NameXiao Er Ke Chuan Ling Granules
Function Description宣肺, 清热, 止咳, 祛痰。用于上呼吸道感染引起的咳嗽。
IndicationsUpper respiratory infection(uri)
Disease ICD-11 Category CA0Z [Upper respiratory tract disorders, unspecified, 上呼吸道疾患，未特指的 ];
Human Tissues Associated with IndicationLung
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1398 Ephedra sinica 麻黄 TCMH1398 ITSAM882-14
TCMH1127 Lonicera japonica 金银花 TCMH1127 ITSAI3881-14
TCMH1219 Semen armeniacae amarum 苦杏仁 TCMH1219
TCMH127 Isatis indigotica 板蓝根 TCMH127 KJ765825
TCMH1931 Gypsum fibrosum 石膏 TCMH1931
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH705 Trichosanthes kirilowii 瓜蒌 TCMH705 ITSAO4359-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT575 PLA2G2A Phospholipase A2 group IIA Hydrolase P14555
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT904 PGR Progesterone receptor Nuclear receptor P06401
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1241 Human rhinovirus 14
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1321 Staphylococcus hominis
TCMT1333 Human rhinovirus 1A
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TYR, XDH 11.9746
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AR, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, FABP3, GSK3B, HSD11B2, HSD17B2, IDO1, IGF1R, MMP2, MMP9, NR3C1, PTGS2, RORC, SRC, TYR 11.9746
[BP] GO:0033993 response to lipid ALPL, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, IDO1, NR3C1, PTGS2, RORC, SRC, TYR 11.3765
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GSK3B, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, MMP2, NR3C1, PTGS2, RORC, SRC, TYR 10.2438
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, FLT3, HSD11B2, NR3C1, PTGS2, RORC, SRC, TYR 9.54253
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, MIF, PTGS2 9.22733
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, IDO1, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PGR, PIM1, PTGS2, SRC, XDH 9.05011
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GSK3B, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, MMP2, MMP9, NR3C1, PTGS2, RORC, SRC, TYR 8.74406
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 8.65596
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TYR, XDH 8.32966
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, GSK3B, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP2, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TYR, XDH 8.32238
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GSK3B, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 7.92391
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FUT7, GBA2, IDO1, MIF, PIM1, PTGS2, TYR, XDH 7.8533
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GSK3B, HSD11B1, HSD17B2, KDR, MET, MIF, MMP2, MMP9, PGR, PIM1, PTGS2, RORC, SRC, TNKS2, TYR 7.8533
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, RORC, SRC 7.75979
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 7.62735
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9, DHFR 7.62735
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, GSK3B, KDR, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 7.52811
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GSK3B, HSD11B2, IGF1R, MMP2, NR3C1, PTGS2, SRC 7.52811
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TYR, XDH 7.52811
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, GSK3B, KDR, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 7.51866
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, PTGS2, TYR, XDH 7.33041
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.06805
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, DHFR, ESR1, F3, FABP3, FABP4, FLT3, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MET, MIF, PTGS2, SRC, TNKS, TNKS2, XDH 7.01443
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, RORC, SRC 6.86811
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GSK3B, IDO1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTGS2, PTPN1, SRC, XDH 6.72684
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PIM1, RORC, SRC 6.72684
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, GSK3B, IDO1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTGS2, PTPN1, SRC 6.72684
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.70657
[BP] GO:0009725 response to hormone AKR1B1, ALPL, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, NR3C1, PTGS2, SRC 6.67995
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.53409
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AR, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, ESRRB, FLT3, GBA2, GSK3B, HSD11B1, HSD17B2, KDR, MMP9, PGR, PIM1, PTGS2, RORC, SRC, TYR 6.21885
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GSK3B, IGF1R, KDR, MMP2, MMP9, NR3C1, PTGS2, RORC, SRC 6.20535
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GSK3B, IDO1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTGS2, PTPN1, SRC, XDH 6.19421
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, GSK3B, IDO1, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTGS2, PTPN1, SRC 6.19421
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GSK3B, IGF1R, KDR, MMP2, NR3C1, PTGS2, RORC, SRC 6.15382
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GSK3B, IDO1, IGF1R, KDR, MIF, MMP9, PIM1, PTGS2, PTPN1, SRC, XDH 6.13229
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, GSK3B, KDR, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 6.09244
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, GSK3B, IDO1, IGF1R, KDR, MIF, MMP9, PIM1, PTGS2, PTPN1, SRC 6.05428
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, GSK3B, IDO1, KDR, MET, MIF, MMP12, MMP2, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 6.01085
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, RORC 5.90424
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PTGS2 5.85355
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC 5.84356
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, FABP4, FLT3, GSK3B, IGF1R, KDR, MIF, MMP2, MMP9, NR3C1, PTGS2, PTPN1, RORC, SRC 5.66134
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GSK3B, IDO1, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PIM1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 5.50322
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GSK3B, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 5.42372
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, GSK3B, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, NR3C1, PTGS2, PTPN1, RORC, SRC, TYR 5.36535
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GSK3B, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 5.30105
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CDK6, CYP1B1, ESR1, GSK3B, IGF1R, MMP2, MMP9, NR3C1, PTGS2, RORC, SRC 5.12892
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, AR, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, PTGS2, RORC, SRC 5.12492
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, RORC 5.05035
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AR, AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GSK3B, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 4.95583
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, MIF, PTGS2 4.95526
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, IDO1, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS2, RORC, SRC, TNKS2, TYR 4.95526
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GSK3B, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 4.92688
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GSK3B, IDO1, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 4.92688
[BP] GO:0048513 animal organ development ACHE, AR, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, SRC, TYR 4.87301
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCL2, CA2, FLT3, HSD11B2, NR3C1, PTGS2, SRC 4.84624
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, KDR, MIF, PTGS2, SRC, TNKS, TNKS2 4.81613
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.80184
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, MIF, PTGS2 4.78798
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, IDO1, MMP2, MMP9, PGR, PTGS2, SRC 4.76946
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, GSK3B, IDO1, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.76474
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, MMP9, PTGS2, SRC 4.71785
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.70176
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, GSK3B, IGF1R, KDR, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 4.64046
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AXL, BCL2, CYP1B1, F3, FLT3, KDR, MET, MIF, PTGS2, PTPN1, SRC, XDH 4.56782
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, MET, MIF, MMP12, MMP2, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 4.54536
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, GSK3B, IGF1R, KDR, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 4.53548
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, DHFR, FABP3, HSD11B2, KDR, NR3C1, PTGS2, SRC 4.51217
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AR, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GSK3B, KDR, MET, MIF, MMP2, MMP9, PGR, PTGS2, RORC, SRC 4.48322
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.45179
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CDK6, CYP19A1, DHFR, ESR1, F3, FABP4, GSK3B, IDO1, IGF1R, MET, MIF, MMP12, MMP2, PTGS2, PTPN1, SRC, XDH 4.3271
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, MMP9, PTGS2, SRC 4.3271
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, MMP9, PTGS2, SRC 4.31305
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, MIF, MMP9, PTGS2, SRC 4.28611
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, NR3C1, PGR, SRC 4.25746
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AR, AURKB, BCL2, CSNK2A1, DHFR, ESR1, ESR2, ESRRA, FABP4, GSK3B, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 4.22421
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MET, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 4.22421
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, PIM1, SRC 4.18091
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC, TNKS 4.08384
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, MET, MIF, PTGS2 3.93025
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, PGR, PTGS2, SRC 3.8637
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, DHFR, ESR1, F3, FLT3, FUT7, GBA2, GSK3B, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 3.79914
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MIF, MMP9, PTGS2, PTPN1, SRC 3.78633
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, NR3C1, PTGS2, SRC 3.7462
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, MIF, PTGS2 3.7462
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DHFR, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 3.72464
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.72406
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 3.69567
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, GSK3B, IGF1R, MET, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS 3.65903
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, DHFR, GBA2, TYR 3.65903
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.65104
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, BCL2, CYP1A1, ESR1, FLT3, MET, MIF, PIM1, SRC, TYR 3.51969
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DHFR, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 3.4497
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MIF, PTGS2 3.42996
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AR, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, F3, GSK3B, IGF1R, KDR, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SRC 3.41962
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AR, AXL, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GSK3B, IGF1R, KDR, MET, MIF, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, SRC, TNKS, TNKS2 3.40793
[BP] GO:0031324 negative regulation of cellular metabolic process APP, AR, AURKB, BCL2, CSNK2A1, DHFR, ESR1, ESR2, ESRRA, FABP4, GSK3B, IGF1R, MET, MIF, MMP12, MMP9, NR3C1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 3.36757
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AR, AXL, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, ESRRB, F3, GSK3B, IDO1, KDR, MET, MIF, MMP12, MMP9, PIM1, PTGS2, SRC, TNKS2, XDH 3.3528
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AR, AURKB, BCL2, CDC25B, DHFR, ESR1, ESR2, F3, FLT3, GSK3B, MET, MIF, MMP9, PTPN1, SRC, TNKS, XDH 3.322
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FLT3, KDR, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 3.322
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FLT3, KDR, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 3.322
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FLT3, GSK3B, IGF1R, KDR, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 3.31904
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 3.3158
[BP] GO:0010605 negative regulation of macromolecule metabolic process APP, AR, AURKB, CSNK2A1, DHFR, ESR1, ESR2, ESRRA, FABP4, GSK3B, IGF1R, KDR, MIF, MMP12, MMP9, NR3C1, PGR, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 3.31003
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DHFR, ESR1, F3, FABP4, FLT3, GSK3B, IGF1R, MIF, MMP9, PTGS2, PTPN1, SRC, TNKS, XDH 3.30524
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 3.27957
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, BCL2, ESR1, ESR2, GSK3B, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 3.21057
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, BCL2, ESR1, ESR2, GSK3B, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 3.19935
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.19935
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, IDO1, MIF, PTGS2 3.19242
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, AR, BCL2, CDC25B, ESRRB, FLT3, KDR, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 3.19242
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.1908
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, KDR, NR3C1, PTGS2, SRC 3.16474
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, GBA2, IDO1, MIF, PIM1, PTGS2, TYR 3.14952
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, GSK3B, PGR, RORC, SRC 3.14807
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, NR3C1, PGR, PTGS2, RORC, SRC, TNKS, TNKS2 3.14549
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC, TNKS 3.13465
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APP, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GSK3B, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 3.12705
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, GSK3B, MET, MMP9, SRC 3.09116
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, AR, BCL2, CDK6, CYP19A1, ESR1, ESR2, GSK3B, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 3.0797
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 3.0797
[BP] GO:0051130 positive regulation of cellular component organization APP, AR, AURKB, AXL, BCL2, ESR1, GSK3B, IGF1R, KDR, MET, MMP1, MMP9, SRC, TNKS, TNKS2 3.063
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, APP, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GSK3B, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 3.05782
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PTGS2 3.04189
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, MIF, MMP9, PTGS2, PTPN1, SRC 3.02696
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, FLT3, HSD11B2, NR3C1, PTGS2 3.00512
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DHFR, FABP3, FLT3, GSK3B, HSD11B2, IGF1R, MMP2, PTGS2, SRC, TYR 2.98403
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, IGF1R, MET, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 2.95445
[BP] GO:0032845 None ADORA1, BCL2, MIF, SRC, TNKS, TNKS2 2.92802
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, IDO1, KDR, MET, MIF, MMP12, MMP9, PIM1, PTGS2, SRC 2.92802
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, IDO1 2.88795
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.8807
[BP] GO:0009115 None AOX1, XDH 2.85281
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.84987
[BP] GO:0001101 response to acid chemical AKR1B1, DHFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.82291
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, FUT7, GBA2, GSK3B, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TYR, XDH 2.8129
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.79967
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GSK3B, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.78318
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, AR, BCL2, CDC25B, FLT3, KDR, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 2.78299
[BP] GO:0043436 oxoacid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, GBA2, IDO1, MIF, PIM1, PTGS2, TYR 2.77568
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, MIF, MMP9, PTGS2, PTPN1, SRC 2.74542
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MET, MMP12, NR3C1, PGR, PTGS2, RORC, SRC, TNKS, TNKS2 2.73055
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, AR, ESR1, FLT3, GSK3B, IGF1R, MMP2, NR3C1, PTGS2, SRC 2.73055
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.72195
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DHFR, FABP3, FLT3, GSK3B, HSD11B2, IGF1R, MMP2, PTGS2, SRC, TYR 2.71605
[BP] GO:0006082 organic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, GBA2, IDO1, MIF, PIM1, PTGS2, TYR 2.71288
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, F3, FLT3, GSK3B, IGF1R, KDR, MET, MIF, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2 2.70463
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 2.70463
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, AR, BCL2, CDC25B, CSNK2A1, ESR1, F3, FLT3, GSK3B, KDR, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 2.69065
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DHFR, ESR1, ESR2, F3, FABP4, FLT3, GSK3B, IGF1R, MET, MIF, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 2.68857
[BP] GO:2000107 negative regulation of leukocyte apoptotic process AURKB, AXL, IDO1, MIF 2.68066
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, MMP9, PTGS2, SRC 2.67746
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, GSK3B, MET, MMP9, SRC, TNKS 2.67746
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.66556
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, BCL2, CDK6, CYP1B1, FABP3, IDO1, PTGS2, XDH 2.64826
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.63557
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GSK3B, HSD11B2, IGF1R, PTGS2, SRC 2.63557
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 2.63496
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GSK3B, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.63326
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.5973
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GSK3B, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.58578
[BP] GO:0071396 cellular response to lipid AR, AXL, CDK6, ESR1, FLT3, NR3C1, RORC, SRC 2.58446
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, GSK3B, KDR, SRC 2.58359
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MET, MMP12, NR3C1, PGR, RORC, SRC, TNKS, TNKS2 2.58359
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PTGS2, SRC 2.57506
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.57226
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.56107
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.53571
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, AR, BCL2, CDC25B, ESRRB, FABP4, FLT3, IGF1R, KDR, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 2.53215
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, NR3C1, SRC 2.52484
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.51836
[BP] GO:0050793 regulation of developmental process APP, AR, AXL, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, ESRRB, F3, GSK3B, IDO1, KDR, MIF, PIM1, PTGS2, RORC, SRC, TNKS2, XDH 2.51723
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PTGS2, SRC 2.50827
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.50827
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.50827
[BP] GO:0009968 negative regulation of signal transduction AR, BCL2, ESR1, ESR2, GSK3B, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 2.49783
[BP] GO:0060748 None AR, PGR 2.49269
[BP] GO:0046110 None AOX1, XDH 2.49269
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.49269
[BP] GO:0048608 reproductive structure development AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, SRC 2.49147
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.48964
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.47222
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, AR, BCL2, CDC25B, ESR1, F3, FLT3, GSK3B, KDR, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 2.46726
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.4488
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, IDO1, PTGS2, SRC 2.43357
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MET, MMP12, NR3C1, PGR, PTPN1, RORC, SRC, TNKS, TNKS2 2.43357
[BP] GO:2001233 regulation of apoptotic signaling pathway AR, BCL2, GSK3B, MIF, MMP9, PTGS2, PTPN1, SRC 2.42803
[BP] GO:0051172 None APP, AR, AURKB, CSNK2A1, DHFR, ESR1, ESR2, ESRRA, FABP4, IGF1R, MIF, MMP12, MMP9, NR3C1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.42286
[BP] GO:0032103 positive regulation of response to external stimulus F3, FABP4, IDO1, KDR, MET, MIF, PTGS2 2.42286
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.42286
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.41735
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, AR, BCL2, CDC25B, FABP4, FLT3, IGF1R, KDR, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 2.41734
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, GSK3B, IDO1, XDH 2.41087
[BP] GO:0002009 morphogenesis of an epithelium AR, BCL2, CA2, CA9, ESR1, MET, SRC 2.40111
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 2.40078
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.38896
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.38896
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.38896
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 2.36428
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.36428
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, AR, FLT3, KDR, MIF, PTPN1, SRC, XDH 2.35519
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.33331
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PTGS2, SRC 2.33067
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, PTGS2 2.33034
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, ESR1, F3, FABP4, IDO1, KDR, MET, MIF, MMP12, PTGS2 2.3182
[BP] GO:0080135 regulation of cellular response to stress APP, CDK6, DHFR, GSK3B, IGF1R, MET, MIF, PTGS2, PTPN1, XDH 2.30287
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, KDR, SRC 2.30285
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, BCL2, CDC25B, DHFR, ESR1, F3, FLT3, GSK3B, MIF, PTPN1, SRC, TNKS, XDH 2.29777
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, IDO1, PTGS2, SRC 2.29595
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.28896
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.27654
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.27583
[BP] GO:0070213 None TNKS, TNKS2 2.26338
[BP] GO:0006145 None AOX1, XDH 2.26338
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.26338
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SRC, XDH 2.26296
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.25917
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.24679
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC 2.24459
[BP] GO:0030154 cell differentiation ALPL, AR, AXL, BCL2, CBR1, CDK6, CYP1A1, ESR1, FABP4, FLT3, FUT7, GSK3B, KDR, MMP2, MMP9, PTGS2, RORC 2.23978
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3 2.21209
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.21209
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.20486
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, GSK3B, MIF, MMP12, PTGS2, SRC 2.20451
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, IDO1 2.17487
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CYP1A1, ESR1, PGR, PTGS2, SRC 2.16215
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.16215
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, DHFR, FLT3 2.13953
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, HSD11B2, PTGS2, SRC, TYR 2.12994
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.12116
[BP] GO:1904646 cellular response to amyloid-beta APP, GSK3B, IGF1R 2.12116
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.096
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, GSK3B, IDO1, MMP12, PTGS2, SRC 2.0922
[BP] GO:0044283 None AKR1B1, ALOX5, CYP19A1, CYP1A1, DHFR, IDO1, MIF, PTGS2 2.0922
[BP] GO:0043696 None CDK6, ESRRB 2.08889
[BP] GO:0043697 None CDK6, ESRRB 2.08889
[BP] GO:0010641 None F3, SRC 2.08889
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, PTGS2, TNKS, TNKS2 2.08762
[BP] GO:0071383 None AR, FLT3, NR3C1, SRC 2.08478
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, HSD11B2, MMP2, PTGS2, SRC, TYR 2.072
[BP] GO:0050678 None AR, CDK6, F3, KDR, MMP12, PGR, XDH 2.06486
[BP] GO:0070229 negative regulation of lymphocyte apoptotic process AURKB, IDO1, MIF 2.04895
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.04895
[BP] GO:0022602 ovulation cycle process BCL2, ESR1, PGR, SRC 2.04895
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2 2.04895
[BP] GO:0050730 None ADORA1, APP, FLT3, MIF, PTPN1, SRC 2.04861
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, FABP4, FLT3, GSK3B, IGF1R, MIF, PTPN1, SRC, TNKS 2.03496
[BP] GO:0006091 generation of precursor metabolites and energy AKR1B1, AOX1, CYP19A1, CYP1A2, GSK3B, IDO1, XDH 2.02787
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, AR, FLT3, IGF1R, KDR, MIF, PTPN1, SRC, XDH 2.02411
[BP] GO:0002682 regulation of immune system process ADORA1, APP, AXL, BCL2, CA2, CDK6, CYP19A1, ESR1, ESRRA, IDO1, MIF, MMP12, MMP2, PTPN1, SRC 2.02411
[BP] GO:0040007 None APP, AR, BCL2, CYP19A1, ESR1, SRC, TNKS2 2.02411
[BP] GO:2000026 regulation of multicellular organismal development APP, AR, AXL, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, F3, GSK3B, IDO1, KDR, PIM1, PTGS2, SRC, XDH 2.02016
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, GSK3B, TNKS 2.0193
[BP] GO:0032204 None AURKB, SRC, TNKS, TNKS2 2.0193
[BP] GO:1904645 response to amyloid-beta APP, GSK3B, IGF1R 2.0193
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.01322
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, PTGS2, SRC, XDH 2.01322
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GSK3B, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TYR, XDH 2.01017
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2, GSK3B, IDO1, SRC, XDH 2.01017
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MET, SRC 2.00764
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.00666
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AR, AURKB, BCL2, CA1, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, KDR, MIF, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 3.64383
[CC] GO:0005829 cytosol AKR1B1, AKR1B10, ALOX5, AOX1, APP, AR, AURKB, BCL2, CA1, CA2, CA7, CBR1, CDC25B, CDK6, CSNK2A1, DHFR, FABP3, FABP4, FLT3, GSK3B, HSD17B1, IDO1, MIF, NR3C1, NR3C2, PGR, PIM1, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 2.92802
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, NR3C2, PTGS2, PTPN1 2.18829
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA4, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GSK3B, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, NR3C1, PIM1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TYR, XDH 2.16418
[CC] GO:0097443 sorting endosome KDR, PTPN1 1.96528
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, TNKS, TYR, XDH 17.043
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GSK3B, HSD17B1, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TYR, XDH 11.1865
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, F3, FLT3, FUT7, GBA2, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 11.0397
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NR3C1, NR3C2, PGR, RORC 10.7932
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.2438
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PTPN1, RORC, TNKS 9.64254
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, RORC 9.22733
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, PTGS2, TYR, XDH 7.74672
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, IDO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 6.97694
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PGR, RORC 6.78815
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PGR, RORC 6.78815
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, IDO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 6.67363
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.50881
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 6.44294
[MF] GO:0008289 lipid binding AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, NR3C1, NR3C2, PGR, RORC 5.71225
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.66869
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, HSD11B2, HSD17B1, IDO1, PTGS2, SRC, XDH 4.76474
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.45179
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, PTGS2, SRC 4.25833
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, PTGS2, SRC 4.06234
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.70982
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.67334
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.51615
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 3.51271
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.45491
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, RORC 3.4446
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.4383
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.35373
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.33299
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, CDK6, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, RORC 3.24083
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.02696
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NR3C1 2.88943
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, RORC 2.87653
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC 2.87332
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.85281
[MF] GO:0003845 None HSD11B1, HSD11B2 2.85281
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TYR 2.78318
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.76598
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.73139
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.71221
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, BCL2, CSNK2A1, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MIF, MMP9, PGR, PTGS2, TYR, XDH 2.67746
[MF] GO:0019899 enzyme binding APP, AR, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, ESR1, ESR2, ESRRB, F3, GSK3B, MET, MIF, NR3C1, PGR, PTGS2, PTPN1, SRC, TNKS2 2.66249
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.49783
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, RORC 2.46015
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC 2.42447
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC 2.31493
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.26338
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GSK3B, HSD11B2, HSD17B1, IDO1, IGF1R, KDR, MET, MMP12, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, XDH 2.23745
[MF] GO:0097159 organic cyclic compound binding ADORA1, AOX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GSK3B, HSD11B2, HSD17B1, IDO1, IGF1R, KDR, MET, MMP12, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, XDH 2.17828
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX5, IDO1, PTGS2 2.16215
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PTPN1, SRC 2.12116
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX5, IDO1, PTGS2 2.12116
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.08889
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC 2.04895


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.5581
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.1254
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 9.1904
Metabolic pathways_Homo sapiens_hsa01100 CBR1, AKR1B1, PTGS2, TYR, GBA2, CYP19A1, DHFR, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, IDO1 6.5511
Pathways in cancer_Homo sapiens_hsa05200 AR, GSK3B, CDK6, FLT3, MMP1, MMP2, BCL2, PTGS2, MMP9, MET, IGF1R 5.7908
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 5.3483
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2 5.2576
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.215
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 4.1658
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 4.215
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.215
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 3.712
Focal adhesion_Homo sapiens_hsa04510 GSK3B, SRC, KDR, BCL2, MET, IGF1R 3.2924
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.9477
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, SRC, ESR1, ESR2 3.0706
Prostate cancer_Homo sapiens_hsa05215 AR, GSK3B, BCL2, IGF1R 2.7924
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.6052
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, CDK6, KDR, BCL2, MET, IGF1R 2.2431
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 2.1406
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, PTGS2 2.2431
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF, TYR 2.7924
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.1902
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, PTGS2 2.1882
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 2.0848
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.1464
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8857
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2, PTGS2 1.8857
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PGR, CDC25B, IGF1R 1.7582
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.7049
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1 2.1048
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.8088
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, PTGS2 1.6461
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, SRC, ESR1 1.6064
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.4935
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.5896
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.6012
Measles_Homo sapiens_hsa05162 GSK3B, CDK6, CSNK2A1 1.4935
Cell cycle_Homo sapiens_hsa04110 GSK3B, CDK6, CDC25B 1.5896
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.3527
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, ESRRB, IGF1R 1.4589
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, CSNK2A1, BCL2 1.1494
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.0436
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9314
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0636
Melanogenesis_Homo sapiens_hsa04916 GSK3B, TYR 1.0038
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.2712
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, SRC 1.0919
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 0.95
Insulin resistance_Homo sapiens_hsa04931 PTPN1, GSK3B 0.9508
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 0.9504
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 0.9876
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, NR3C1 0.9112
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3527
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2632
Colorectal cancer_Homo sapiens_hsa05210 GSK3B, BCL2 1.3013
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.164
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.9314
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B, BCL2 0.9285
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9314
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2592
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3332
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, GSK3B 0.8468
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B, CSNK2A1 0.8362
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8468
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.2553
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 0.9031
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2 0.7899
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.7607
Alzheimer's disease_Homo sapiens_hsa05010 GSK3B, APP 0.7607
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7291
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.654
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, SRC 0.699
HTLV-I infection_Homo sapiens_hsa05166 GSK3B 0.2437
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2439
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.2918
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, NR3C2 1.6012
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3308
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3505
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3436
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1 0.311
Influenza A_Homo sapiens_hsa05164 GSK3B 0.3436
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3851
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B 0.3803
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B 0.3815
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4008
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4152
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.743
Hepatitis C_Homo sapiens_hsa05160 GSK3B 0.4152
Platelet activation_Homo sapiens_hsa04611 SRC 0.4323
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4298
Dopaminergic synapse_Homo sapiens_hsa04728 GSK3B 0.4193
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B 0.4864
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5013
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.4936
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5061
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5058
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5054
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5147
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5153
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5164
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5164
Gap junction_Homo sapiens_hsa04540 SRC 0.5164
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5158
Peroxisome_Homo sapiens_hsa04146 XDH 0.5272
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5648
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B 0.5648
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7049
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.636
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5423
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5648
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5635
Bile secretion_Homo sapiens_hsa04976 CA2 0.5648
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.584
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.584
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.584
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5709
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9031
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.584
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5964
Shigellosis_Homo sapiens_hsa05131 SRC 0.584
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.584
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.6192
Endometrial cancer_Homo sapiens_hsa05213 GSK3B 0.64
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.6221
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6432
Malaria_Homo sapiens_hsa05144 MET 0.6503
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.654
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.6467
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.654
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.654
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.654
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.7486
Folate biosynthesis_Homo sapiens_hsa00790 DHFR, ALPL 2.2189
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7833
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7951
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7951
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8242
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7899
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8139
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.9314
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 0.9052
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9314
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0314
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2711


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)