TCM Prescription: Fu Fang Wu Ji Oral Liquid



Prescription Description
Prescription IDTCMF6935
Pinyin NameFu Fang Wu Ji Kou Fu Ye
Chinese Name复方乌鸡口服液
English NameFu Fang Wu Ji Oral Liquid
Function Description补气血, 益肝肾。主治妇女病气血两虚或肝肾两虚的月经量少, 后错; 脾虚或肾虚带下。症见面色白光白, 五心烦热, 腰酸膝软。
IndicationsIrregular menstruation
Disease ICD-11 Category GA20.3 [Abnormal regularity of uterine bleeding, 子宫出血周期异常 ];
Human Tissues Associated with IndicationUterus
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2183 Gallus domesticus 乌鸡 TCMH2183
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH1845 Dioscorea batatas 山药 TCMH1845
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH1513 Paeonia moutan 牡丹皮 TCMH1513
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 12.2695
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.3258
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX12, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FUT7, GLO1, HSPA1A, PIM1, PPARA, TYR, XDH 9.88264
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, PPARA, TRPV1 9.64685
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, TOP2A, TRPV1, TYR, XDH 9.22642
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APEX1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, NR3C1, PPARA, SMAD3, SRC, TEK, TRPV1, TYR 8.44762
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, F10, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, PPARA, SMAD3, SRC, TEK, TRPV1, XDH 8.27376
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 7.92761
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 7.79766
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, HSD17B2, IGF1R, INSR, MMP2, MMP9, NR3C1, PPARA, SRC, TEK, TRPV1, TYR 7.56451
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, APEX1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PPARA, SMAD3, SRC, TEK, TRPV1, TYR 7.18326
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP12, MMP9, SMAD3, SRC, TEK, XDH 7.16736
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP12, MMP9, SMAD3, SRC, TEK, XDH 7.16736
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, KDR, MMP9, PIM1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 7.1633
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, NR3C1, PPARA, SMAD3, SRC, TEK, TRPV1 7.02273
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, NR3C1, PPARA, SRC, TEK, TRPV1 6.892
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX12, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NR3C1, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, TOP2A, TYR, XDH 6.87225
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 6.78433
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.61557
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, TRPV1 6.45711
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SMAD3, SRC, TEK 6.45711
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.45711
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.3633
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, F10, FABP3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 6.3355
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, SMAD3, SRC, TEK 6.2045
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.15057
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APEX1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, SMAD3, SRC, TEK, TRPV1 6.09753
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, APEX1, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 6.05885
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX12, ALOX15, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, TYR, XDH 6.04249
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC 6.03647
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, CSNK2A1, CYP1B1, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, SMAD3, SRC, TEK, XDH 5.89513
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APEX1, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, SMAD3, SRC, TRPV1 5.86512
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, APEX1, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.70739
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.62582
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, HSD11B1, HSD17B1, HSD17B2 5.62142
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, FABP3, FABP4, FUT7, MET, PPARA 5.62142
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, NR3C1, SRC, TEK, TRPV1, TYR 5.59243
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 5.56143
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.55569
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MMP9, PIM1, SMAD3, SRC, TEK 5.55061
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 5.5162
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.5162
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, APEX1, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.32614
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, TRPV1 5.31883
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, APEX1, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.31883
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD11B1, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 5.19588
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, SRC, TEK, XDH 5.19221
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, SMAD3, SRC, TEK, XDH 5.08286
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APEX1, AXL, CYP1A1, CYP1B1, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, NR3C1, SMAD3, SRC, TRPV1 5.04826
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.0226
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA 5.01456
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.01456
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APEX1, AURKB, AXL, CA2, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, F10, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NR3C1, NUAK1, PPARA, SMAD3, SRC, TEK, TOP2A, TRPV1, TYR 5.01456
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APEX1, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, NUAK1, SMAD3, SRC, TOP2A, TRPV1 4.93822
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.93822
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, NR3C1, SRC, TYR 4.8593
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AXL, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, SRC, TEK, XDH 4.8593
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 4.84674
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.84674
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, HCAR2, HSD11B1, HSD17B1, HSD17B2 4.77322
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 4.59472
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, TOP2A, TRPV1, TYR, XDH 4.51253
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APEX1, AURKB, AXL, CA2, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TOP2A, TYR 4.51253
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 4.49739
[BP] GO:0030335 positive regulation of cell migration ALOX12, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.46564
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, APEX1, AXL, CA12, CA2, CA7, EGFR, FABP3, FABP4, FLT3, GPR35, INSR, MET, SMAD3, SRC, TRPV1 4.42091
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, ALPL, AXL, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, FABP4, HSD17B2, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TRPV1, TYR 4.40478
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 4.3506
[BP] GO:2000147 positive regulation of cell motility ALOX12, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.3298
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.21309
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, EGFR, KDR, NR3C1, SRC, TRPV1 4.20744
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PPARA 4.15381
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, SRC, TEK, XDH 4.09916
[BP] GO:0040017 positive regulation of locomotion ALOX12, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.08233
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.06894
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, SRC, TEK 3.99934
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, EGFR, F10, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP9, SMAD3, SRC, TEK, XDH 3.98937
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, SRC, TEK 3.93757
[BP] GO:0009056 catabolic process ACHE, ADORA1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.90662
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.8952
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, TOP2A, TRPV1, TYR, XDH 3.87761
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TRPV1, TYR 3.8523
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.84424
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.71869
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.68067
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.68067
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 3.6131
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK 3.6131
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 3.59339
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, IGF1R, INSR, PPARA, SRC, TEK, TRPV1 3.52911
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GLO1, GPR35, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIM1, PPARA, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 3.52669
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TRPV1, TYR 3.52566
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, EGFR, PPARA, SMAD3 3.52566
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, EGFR, FLT3, NR3C1, SRC, TRPV1 3.52303
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, AURKB, AXL, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, XDH 3.51877
[BP] GO:0001503 ossification ALOX15, ALPL, EGFR, MMP2, MMP9, TEK 3.51877
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, HSD11B1, HSD17B2, INSR, KDR, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TYR 3.40931
[BP] GO:0080134 regulation of response to stress ADORA1, ALOX12, CYP19A1, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 3.40087
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PIM1, PPARA, TYR 3.344
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, EGFR, HSPA1A, MMP2, PPARA, SMAD3, SRC, TEK, TRPV1, TYR 3.344
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GLO1, GPR35, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIM1, PPARA, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 3.344
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 3.29874
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, EGFR, FABP3, KDR, NR3C1, SRC, TRPV1 3.28278
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TOP2A 3.25708
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, AURKB, AXL, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, XDH 3.25337
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.23466
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, TEK 3.22884
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CYP1B1, EGFR, IGF1R, INSR, MMP2, MMP9, NR3C1, SRC, TRPV1 3.19092
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 3.0464
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.98573
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.97226
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, CA12, CA2, CA7, EGFR, FABP3, FABP4, GPR35, INSR, MET, SMAD3, TRPV1 2.93553
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.92927
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PIM1, PPARA, TYR 2.92176
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.88808
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, SMAD3, TRPV1 2.88808
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.88808
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PIM1, PPARA, TYR 2.85203
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, EGFR, FLT3, IGF1R, INSR, MMP2, NR3C1, SMAD3, SRC, TRPV1 2.85203
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.85203
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.85203
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.85203
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, SMAD3, TRPV1, XDH 2.84776
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.8296
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX12, ALOX15, CYP19A1, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, SMAD3, SRC, TEK, XDH 2.75545
[BP] GO:0071363 cellular response to growth factor stimulus EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 2.75545
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, TYR 2.75545
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.7535
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 2.74717
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, AXL, CA2, CA7, CYP19A1, EGFR, GPR35, HCAR2, HSPA1A, INSR, MMP12, MMP9, PPARA, SMAD3, SRC, TRPV1 2.74249
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, SRC, TEK, XDH 2.69031
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, INSR, SMAD3, TRPV1, XDH 2.66923
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.66555
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK 2.65544
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.65544
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.65544
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.65544
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.65544
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.64578
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.64433
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DUSP3, EGFR, F10, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, TOP2A, TYR, XDH 2.64433
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, CYP1A1, CYP1A2, CYP1B1, EGFR 2.64433
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, EGFR, HCAR2, KDR, SRC, TRPV1 2.63587
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, AXL, CA2, CYP1B1, EGFR, HCAR2, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, SMAD3, SRC, TEK, TRPV1 2.63587
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, PPARA, SRC, TEK 2.62601
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, NR3C1, SRC 2.58756
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, MMP2, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, TOP2A, TRPV1 2.58756
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.58756
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 2.58756
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.58756
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.5842
[BP] GO:0006721 terpenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 2.57366
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.5672
[BP] GO:0016042 lipid catabolic process ADORA1, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.56537
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.56077
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 2.55642
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.53418
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.53418
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, EGFR, HCAR2, MMP12, SRC, TRPV1 2.50803
[BP] GO:0043434 None APEX1, FABP3, INSR, PPARA, SRC, TEK, TRPV1 2.50002
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.50002
[BP] GO:0070848 response to growth factor EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 2.50002
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 2.47314
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.46386
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.46386
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.46106
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, EGFR, FLT3, INSR, KDR, SRC, TEK, XDH 2.45467
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, EGFR, FABP4, KDR, MET, MMP12, PPARA, SMAD3, TEK 2.44345
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, EGFR, IGF1R, INSR, MMP2, SRC, TRPV1 2.43177
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, FABP4, HSPA1A, MMP12, MMP2, PPARA, SMAD3, SRC, TEK 2.42734
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, MET, TRPV1 2.41853
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4 2.41853
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.40592
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, EGFR, FLT3, MET, PIM1, SRC, TEK, TYR 2.39298
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.39165
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, CYP1A1, CYP1B1, KDR, SRC 2.39165
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.37484
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, AURKB, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TOP2A 2.37484
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, EGFR, HSPA1A 2.36981
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, TOP2A, TRPV1, TYR, XDH 2.35798
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.35438
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, CA2, CYP19A1, EGFR, HCAR2, INSR, MMP12, SMAD3, SRC, TRPV1 2.33787
[BP] GO:0030155 regulation of cell adhesion ALOX12, ALOX15, CYP1B1, DUSP3, KDR, NUAK1, PPARA, SMAD3, SRC, TEK 2.33274
[BP] GO:0006720 isoprenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 2.33025
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.33025
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP1A1, CYP1B1, CYP3A4, TYR 2.32621
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.31029
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, KDR, SRC, TRPV1 2.30645
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.29206
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.27243
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.27243
[BP] GO:0051894 None KDR, SMAD3, TEK 2.27243
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.27243
[BP] GO:0016310 phosphorylation AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.25984
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, EGFR, IGF1R, INSR, MMP2, SRC, TRPV1 2.24993
[BP] GO:0010038 response to metal ion ALOX15, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.21291
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, DUSP3, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, SRC 2.21291
[BP] GO:0048545 response to steroid hormone ALPL, CA2, EGFR, FLT3, NR3C1, SRC 2.2124
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, AURKB, AXL, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.2013
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, SRC 2.19818
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.19007
[BP] GO:1903393 None KDR, SMAD3, TEK 2.19007
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.15738
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.13887
[BP] GO:0071383 None EGFR, FLT3, NR3C1, SRC 2.11903
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.095
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.095
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.08503
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9 2.08503
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK, TRPV1 2.08145
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, SRC 2.08145
[BP] GO:0042060 None ALOX15, EGFR, PPARA, SMAD3 2.07073
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.03243
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.03243
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.03201
[BP] GO:0048732 gland development CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.02088
[BP] GO:1901890 None KDR, SMAD3, TEK 2.00043
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.00043
[BP] GO:0006691 None ALOX12, ALOX15, ALOX5 2.00043
[BP] GO:1901655 None AKR1B1, EGFR, NR3C1, SRC 2.00043
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.00043
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.50803
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, F10, FLT3, FUT7, GLO1, GPR35, HCAR2, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MET, MMP2, PIM1, SMAD3, SRC, TEK, TRPV1, TYR 2.37484
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, EGFR, F10, FLT3, GLO1, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MMP2, PIM1, SMAD3, SRC, TEK, TRPV1 2.35438
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, APEX1, AURKB, CA1, CA2, CA4, CA5A, CA5B, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MMP2, MMP9, NR3C1, PIM1, SMAD3, SRC, TOP2A, TRPV1, TYR, XDH 2.27243
[CC] GO:0032589 None ADORA1, INSR, TRPV1 1.71043
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 17.4567
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, SMAD3, TYR, XDH 16.9066
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, F10, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, SRC, TEK, TOP2A, TYR, XDH 14.4778
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, F10, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, TOP2A, TRPV1, TYR, XDH 13.8547
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.6542
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.3559
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 8.9969
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 8.58522
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH 8.34049
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, SMAD3, TOP2A, TRPV1, TYR, XDH 8.30335
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, SMAD3, TOP2A, TRPV1, TYR, XDH 7.91217
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.66573
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX12, ALOX15, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, TYR, XDH 7.16736
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 7.16736
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.95163
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK, TOP2A, TRPV1 6.87225
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, PPARA, SMAD3 6.58352
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR 6.42558
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.62142
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 5.61062
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC 5.55961
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC 5.33726
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR 5.01456
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 4.71209
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.51253
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, NR3C1 4.16249
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, SMAD3, SRC 4.08229
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.71289
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, SMAD3, SRC 3.66908
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.35614
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.35614
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.34945
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, SRC, XDH 3.32375
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.85203
[MF] GO:0008389 None CYP2A13, CYP2A6 2.85203
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, TRPV1 2.79465
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, TRPV1, XDH 2.77272
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, TRPV1 2.69031
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.68726
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, TRPV1 2.66555
[MF] GO:0043168 anion binding ALOX15, AURKB, AXL, CSNK2A1, EGFR, F10, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, TRPV1, XDH 2.61868
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSPA1A, KDR, NR3C1 2.5951
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, TEK, TRPV1 2.5914
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.50002
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.50002
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.50002
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.33274
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, F10, FABP3, FABP4, HSD17B1, NR3C1, PPARA, TRPV1 2.30632
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.27243
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.27243
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.27243
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, TRPV1, XDH 2.21291
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, TRPV1, XDH 2.2124
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, SMAD3, TEK, TRPV1 2.2029
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, HSD11B1, HSD17B1, HSD17B2, XDH 2.19818
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5 2.19007
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.14485
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5 2.14485
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, TEK, TRPV1 2.1347
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CSNK2A1, DUSP3, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, SRC, TEK 2.09694
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.095
[MF] GO:0043559 insulin binding IGF1R, INSR 2.095
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD17B1, HSD17B2 2.07255
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.07255
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, TEK, TRPV1 2.0086


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 19.0061
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 9.7577
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 9.3894
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 7.0962
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.0962
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.8589
Metabolic pathways_Homo sapiens_hsa01100 ALOX15, AKR1B1, ALOX12, TYR, CYP3A4, CYP19A1, HSD11B1, CYP2A6, FUT7, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 4.934
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.492
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, EGFR, IGF1R 4.3828
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 4.3134
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.8049
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R 3.542
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, EGFR, HSPA1A 3.806
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.2406
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, CYP3A4 3.3539
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2798
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, TEK, MET, EGFR, IGF1R 2.4203
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.6038
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.702
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.3791
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.7364
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.4051
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1, TRPV1, NR3C1 2.152
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.2869
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, EGFR 2.0413
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.6038
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, ALOX12 2.3107
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.245
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2415
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.2163
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.0413
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.1343
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, CYP3A4 2.2379
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1 1.8687
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 1.8938
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.9727
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, ALOX15, ALOX12 1.7542
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.5074
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.4602
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.326
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1, PPARA 1.1727
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, HSPA1A 0.9718
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.2836
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.0932
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.326
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3617
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 1.0921
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.2806
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.065
Insulin resistance_Homo sapiens_hsa04931 INSR, PPARA 0.9718
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.0927
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1722
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.0915
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.9255
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.2303
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.8453
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9255
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.9197
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8551
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.9017
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.833
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.833
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.8289
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8356
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8153
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.791
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.6704
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.6457
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.2569
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3223
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3611
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3546
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3483
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.3539
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3542
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3546
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3802
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3876
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3481
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4264
Insulin signaling pathway_Homo sapiens_hsa04910 INSR 0.4171
Platelet activation_Homo sapiens_hsa04611 SRC 0.4468
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4468
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4722
Cell cycle_Homo sapiens_hsa04110 SMAD3 0.4468
Axon guidance_Homo sapiens_hsa04360 MET 0.4419
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4537
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.4957
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4722
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4957
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4957
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4885
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4957
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4989
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5071
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4989
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5029
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5209
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5114
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5114
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5113
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5532
Peroxisome_Homo sapiens_hsa04146 XDH 0.5211
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5541
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5522
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5358
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5414
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5605
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5789
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5804
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5929
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.3218
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.5849
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.5804
Shigellosis_Homo sapiens_hsa05131 SRC 0.5804
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6107
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.5948
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6302
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6128
Malaria_Homo sapiens_hsa05144 MET 0.6457
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.647
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.7153
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0413
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7486
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7104
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.7836
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8153
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.776
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7486
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.7685
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7617
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.7426
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8153
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8153
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9813


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)