TCM Prescription: Gu Tong Tie Ointment



Prescription Description
Prescription IDTCMF6920
Pinyin NameGu Tong Tie Gao
Chinese Name骨通贴膏
English NameGu Tong Tie Ointment
Function Description祛风散寒, 活血通络, 消肿止痛。用于寒湿阻络兼血瘀证之局部关节疼痛, 肿胀, 麻木重着, 屈伸不利或活动受限; 退行性骨关节炎见上述证候者。
IndicationsNumbness disorder, Blood stasis pattern, Arthritis, Rheumatoid arthritis
Disease ICD-11 Category SC62 [Numbness disorder (TM1), 麻木 (TM1) ];
SF01 [Blood stasis pattern (TM1), 血瘀证 (TM1) ];
FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病，未特指的 ];
FA20 [Rheumatoid arthritis, 类风湿性关节炎 ];
Human Tissues Associated with IndicationBlood, SkeletaMuscle
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH482 Erycibe obtusifolia 丁公藤 TCMH482 MG730256
TCMH1398 Ephedra sinica 麻黄 TCMH1398 ITSAM882-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH776 Piper kadsura 海风藤 TCMH776 EF450290
TCMH1753 Boswellia carterii 乳香 TCMH1753
TCMH1768 Panax notoginseng 三七 TCMH1768 ITSAO2360-14
TCMH1063 Curcuma longa 姜黄 TCMH1063 ITSAP2805-14
TCMH1228 Capsicum frutescens 辣椒 TCMH1228 ITSAL4555-14
TCMH2585 Cinnamomum camphora 樟脑 TCMH2585 SDH069-14
TCMH1745 NA 肉桂油 TCMH1745
TCMH1092 Stephania sinica 金不换 TCMH1092 KJ566150
TCMH189 Mentholum 薄荷脑 TCMH189
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT320 MMP3 Matrix metalloproteinase 3 Hydrolase P08254
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT466 MAPK9 c-Jun N-terminal kinase 2 Kinase P45984
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT594 PTAFR Platelet activating factor receptor GPCR P25105
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT601 F2 Thrombin Unclassified P00734
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT904 PGR Progesterone receptor Nuclear receptor P06401
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT962 ENPP2 Autotaxin Hydrolase Q13822


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.8513
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.8902
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APP, AR, AXL, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FABP3, HMGCR, HSD17B2, IGF1R, MMP2, MMP3, MMP9, NR3C1, PPARA, PRKCD, PTAFR, PTGES, SRC, TRPV1, TYR 11.9822
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP3, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PRKCD, PTAFR, PTGES, SRC, TRPV1, TYR, XDH 11.7049
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, HMGCR, MIF, PIM1, PPARA, PTAFR, PTGES, TYR, XDH 11.6474
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, FABP3, FABP4, HMGCR, HSD11B1, HSD17B1, HSD17B2, MET, MIF, PPARA, PTGES, TRPV1 10.7848
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 9.77433
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, HMGCR, HSD11B1, HSD17B1, HSD17B2 9.77433
[BP] GO:0010033 response to organic substance AKR1B1, APP, AR, AXL, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KDR, MMP2, NR3C1, PPARA, PRKCD, PTAFR, PTGES, SRC, TRPV1, TYR 9.24319
[BP] GO:0042221 response to chemical AKR1B1, APP, AR, AXL, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KDR, MMP2, MMP3, MMP9, NR3C1, PPARA, PRKCD, PTAFR, PTGES, SRC, TRPV1, TYR 8.43401
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, CSNK2A1, CYP1B1, ESR1, ESRRA, F2, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PGR, PIM1, PTAFR, PTGES, SRC, XDH 8.00487
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, SRC 7.66094
[BP] GO:0014070 response to organic cyclic compound APP, AR, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FLT3, NR3C1, PTAFR, PTGES, SRC, TRPV1, TYR 7.5689
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MIF, MMP1, MMP2, NR3C1, NR3C2, PGR, PIM1, PPARA, PRKCD, PTAFR, PTGES, SRC, TYR, XDH 7.46211
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MIF, PTGES 7.45459
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APP, AR, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, ESRRA, FABP3, FLT3, IGF1R, MMP2, NR3C1, PPARA, PRKCD, PTAFR, SRC, TRPV1 7.29225
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD1, ESR1, F2, F3, FABP3, FABP4, FLT3, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2, KDR, MAOA, MET, MIF, PPARA, PRKCD, PTAFR, SRC, TRPV1, XDH 7.24959
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MIF, PTGES 7.22173
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, TRPV1 7.06898
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, HCAR2, HMGCR, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP3, MMP9, NR3C1, PGR, PIM1, PPARA, PRKCD, PTAFR, SRC, TRPV1, XDH 6.85773
[BP] GO:0033993 response to lipid AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, NR3C1, PTAFR, PTGES, SRC, TYR 6.81996
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, SRC 6.79258
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PIM1, PPARA, SRC 6.62621
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, HMGCR, IGF1R, KDR, MET, MIF, MMP3, MMP9, PIM1, PPARA, PRKCD, SRC, TRPV1, XDH 6.62621
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP3, MMP9, PRKCD, PTGES, SRC 6.60836
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F2, F3, FLT3, HCAR2, HMGCR, KDR, MET, MIF, MMP12, MMP9, PRKCD, SRC, XDH 6.60836
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F2, F3, FLT3, HCAR2, HMGCR, KDR, MET, MIF, MMP12, MMP9, PRKCD, SRC, XDH 6.58051
[BP] GO:0009725 response to hormone AKR1B1, AR, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, NR3C1, PPARA, PRKCD, PTAFR, SRC, TRPV1 6.53694
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES 6.51877
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HMGCR, HSD11B1, HSD17B1, HSD17B2, MAOA, TYR, XDH 6.38589
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HCAR2, HMGCR, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP3, MMP9, NR3C1, PGR, PIM1, PPARA, PRKCD, PTAFR, SRC, TRPV1, XDH 5.89945
[BP] GO:0042493 response to drug AKR1B1, AXL, CA3, CA9, CYP1A1, CYP1B1, DRD1, FABP3, HMGCR, KDR, MMP3, NR3C1, PRKCD, PTAFR, SRC, TRPV1 5.89755
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MIF, PTGES 5.89755
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, KDR, MMP3, NR3C1, PRKCD, PTAFR, SRC, TRPV1 5.88495
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PIM1, PRKCD, SRC, TRPV1, XDH 5.81051
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA 5.79956
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, TRPV1 5.79675
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CYP1B1, DRD1, ESR1, IGF1R, MMP2, MMP3, MMP9, NR3C1, PRKCD, PTAFR, SRC, TRPV1 5.78762
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.78553
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.78553
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, MIF, PPARA, PTGES 5.71772
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.5436
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CA2, CA3, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, F2, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KDR, MIF, MMP12, MMP2, MMP3, MMP9, NR3C1, PPARA, PRKCD, PTAFR, PTGES, SRC, TRPV1, TYR 5.48104
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD17B1, HSD17B2 5.33714
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP3, MMP9, NR3C1, PRKCD, PTAFR, SRC, TRPV1 5.33221
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, HMGCR, IGF1R, KDR, MIF, MMP9, PIM1, PRKCD, SRC, TRPV1, XDH 5.23693
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRB, F2, F3, FABP4, HMGCR, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP3, MMP9, PIM1, PPARA, PRKCD, PTAFR, SRC, TRPV1, TYR 5.21163
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FABP4, HMGCR, MET, MIF, PPARA, PTGES 5.20096
[BP] GO:0071407 cellular response to organic cyclic compound APP, AR, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, NR3C1, PTAFR, SRC, TRPV1 5.04887
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA 5.00353
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, CSNK2A1, ESR1, F2, F3, FLT3, HMGCR, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PTAFR 4.93719
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP3, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PRKCD, PTAFR, PTGES, SRC, TRPV1, TYR, XDH 4.8651
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES 4.84068
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F2, F3, HCAR2, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PRKCD, PTAFR, SRC, TRPV1 4.78951
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, DRD1, F2, HCAR2, HMGCR, KDR, MIF, SRC, TRPV1 4.72111
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PPARA, SRC, TYR 4.72111
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.63979
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP3, MMP9, PRKCD, SRC 4.63979
[BP] GO:0071310 cellular response to organic substance AKR1B1, APP, AR, AXL, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, NR3C1, PRKCD, PTAFR, SRC, TRPV1 4.57297
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PRKCD, SRC 4.55806
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, MAOA, MMP1, MMP12, MMP2, MMP3, MMP9, SRC, XDH 4.55777
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP3, MMP9, NR3C1, PIM1, PPARA, PRKCD, PTGES, SRC, TRPV1, XDH 4.55777
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, ESRRA, F2, F3, FABP4, FLT3, HMGCR, KDR, MET, MIF, MMP12, MMP2, MMP3, MMP9, PRKCD, PTAFR, SRC, XDH 4.55028
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AR, AURKB, CSNK2A1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PRKCD, PTAFR, SRC, TRPV1, XDH 4.48213
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, HCAR2, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP3, MMP9, NR3C1, PGR, PIM1, PPARA, PRKCD, PTGES, SRC, TRPV1, XDH 4.4759
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2 4.4494
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1B1, DRD1, HMGCR, MAOA, PTAFR, TYR 4.42803
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP3, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PRKCD, PTGES, SRC, TRPV1, TYR, XDH 4.38571
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PIM1, PRKCD, SRC 4.31767
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, NR3C1, PGR, SRC 4.20015
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AR, AURKB, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PRKCD, PTAFR, SRC, TRPV1, XDH 4.16603
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, MET, MIF, MMP9, PTAFR, SRC 4.15276
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, ESR1, F2, F3, FABP4, HMGCR, KDR, MET, MIF, MMP12, PPARA, PRKCD 4.08714
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, MIF, PRKCD, PTAFR 4.08714
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AR, AURKB, CSNK2A1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PRKCD, PTAFR, SRC, TRPV1, XDH 4.05278
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, IGF1R, KDR, MET, MMP12, NR3C1, PGR, PPARA, PRKCD, PTAFR, SRC, TRPV1 4.05278
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, F2, FABP3, FLT3, HCAR2, HMGCR, PPARA, PRKCD, SRC 4.02819
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F2, F3, FLT3, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PRKCD, SRC, XDH 4.02108
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, AR, DRD1, ESR1, FLT3, IGF1R, MMP2, NR3C1, PRKCD, PTAFR, SRC, TRPV1 3.97502
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AR, AURKB, CSNK2A1, CYP2D6, ESR1, ESR2, ESRRA, F2, FABP4, HCAR2, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP3, MMP9, NR3C1, PGR, PPARA, PRKCD, SRC, TRPV1, XDH 3.96493
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, F2, F3, FLT3, HMGCR, KDR, MET, MIF, MMP12, MMP9, PRKCD, SRC, XDH 3.95312
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, F2, KDR, SRC, TRPV1 3.93861
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DRD1, FABP3, FLT3, IGF1R, MMP2, MMP3, PPARA, PRKCD, PTAFR, SRC, TRPV1, TYR 3.87789
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, CA2, CYP1B1, ESRRB, F2, F3, HCAR2, HMGCR, KDR, MET, MIF, MMP12, MMP9, PIM1, PTAFR, SRC, TRPV1 3.87789
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, MIF, PPARA, PTGES 3.87538
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, MET, MIF, MMP9, PTAFR, SRC 3.87538
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, F2, F3, FLT3, HCAR2, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP9, PRKCD, SRC, XDH 3.84891
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, CA2, CYP19A1, DRD1, F2, HCAR2, MIF, MMP12, PRKCD, PTAFR, SRC, TRPV1 3.82317
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, AR, DRD1, ESRRB, F2, FABP3, FLT3, HMGCR, KDR, MIF, MMP9, PRKCD, PTAFR, SRC, XDH 3.82317
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, AR, DRD1, ESRRB, F2, FABP3, FLT3, HMGCR, KDR, MIF, MMP9, PRKCD, PTAFR, SRC, XDH 3.82317
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AXL, CYP1B1, F2, F3, FLT3, HMGCR, KDR, MET, MIF, SRC, XDH 3.76301
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, F2, F3, FLT3, HCAR2, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP9, PRKCD, SRC, XDH 3.75839
[BP] GO:0051716 cellular response to stimulus AKR1B1, APP, AR, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MIF, MMP2, MMP3, MMP9, NR3C1, PRKCD, PTAFR, SRC, TRPV1 3.734
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, HMGCR, IGF1R, KDR, MIF, MMP9, PIM1, PRKCD, SRC 3.71111
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CA3, CYP1A1, CYP1B1, DRD1, HMGCR, KDR, PRKCD, SRC 3.69598
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.64439
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AR, AURKB, CSNK2A1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PRKCD, PTAFR, SRC, XDH 3.63859
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, HMGCR, HSD11B1, HSD17B2, KDR, MET, MIF, MMP2, MMP9, PGR, PIM1, PPARA, PRKCD, SRC, TYR 3.63234
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, ESR1, F2, F3, FABP4, HMGCR, IGF1R, MET, MIF, MMP12, MMP2, MMP3, PPARA, PRKCD, SRC, XDH 3.56771
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, ESR1, FABP4, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PRKCD, SRC 3.53459
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DRD1, FABP3, FLT3, IGF1R, MMP2, PPARA, PRKCD, PTAFR, SRC, TRPV1, TYR 3.53359
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP3, MMP9, TRPV1 3.53359
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, MET, MIF, MMP9, PTAFR, SRC 3.53037
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD1, MAOA 3.52921
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, MET, MIF, MMP9, PTAFR, SRC 3.51966
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DRD1, IGF1R, MMP2, MMP3, PRKCD, PTAFR, SRC, TRPV1 3.48751
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 3.46412
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CYP1A1, ESR1, FLT3, MET, MIF, PIM1, PRKCD, SRC, TYR 3.45475
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP3, MMP9, PRKCD, SRC 3.44266
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AR, AXL, CA1, CA2, CSNK2A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PRKCD, PTAFR, PTGES, SRC, TRPV1 3.39649
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, CA3, CYP1B1, MMP3, MMP9, PRKCD, SRC 3.38915
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, NR3C1, PTAFR, SRC 3.38915
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD11B1, HSD17B1, HSD17B2, MIF, PTGES 3.36924
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP3, MMP9 3.35038
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, APP, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, ESRRB, F2, FLT3, HSD11B1, HSD17B2, KDR, MMP9, PGR, PIM1, PPARA, SRC, TYR 3.28066
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, PRKCD, SRC 3.28019
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, PRKCD, SRC 3.23715
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FABP3, FLT3, PPARA, PRKCD, SRC 3.21763
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, AR, DRD1, ESRRB, F2, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MIF, MMP9, PPARA, PRKCD, PTAFR, SRC, XDH 3.20249
[BP] GO:2001225 regulation of chloride transport CA2, CA7, PTAFR 3.18821
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.18821
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HMGCR 3.18821
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, MMP3, MMP9, PRKCD, SRC 3.17911
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HMGCR, HSD11B1, HSD17B1, HSD17B2 3.17366
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AR, AXL, CA2, CYP1B1, ESR1, ESRRA, ESRRB, F2, F3, HCAR2, HMGCR, KDR, MET, MIF, MMP12, MMP9, PIM1, PRKCD, PTAFR, SRC, TRPV1, XDH 3.17074
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, AR, DRD1, ESRRB, F2, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MIF, MMP9, PPARA, PRKCD, PTAFR, SRC, XDH 3.17074
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.1606
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, F2, HMGCR, MIF, PPARA, PRKCD 3.14892
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP3, MMP9 3.14718
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, F2, F3, FABP4, FLT3, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP2, MMP3, MMP9, PPARA, PRKCD, PTAFR, SRC, XDH 3.11283
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, DRD1, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MET, MMP12, NR3C1, PGR, PPARA, PRKCD, PTAFR, SRC, TRPV1 3.08627
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 3.08169
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, HCAR2, MIF, MMP12, PTAFR, SRC, TRPV1 3.08169
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTAFR 3.08133
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, MIF, PIM1, PPARA, PTGES, TYR 3.06959
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, PRKCD, SRC 3.06352
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, DRD1, HMGCR, MMP2, PPARA, PTAFR, SRC, TRPV1, TYR 3.04623
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP3, MMP9 3.01086
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DRD1, IGF1R, MMP2, PRKCD, PTAFR, SRC, TRPV1 2.98223
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP3, MMP9 2.96233
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, AR, CYP19A1, DRD1, ESR1, ESR2, F2, HMGCR, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PRKCD, SRC, XDH 2.96039
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, AR, DRD1, ESRRB, F2, FABP4, FLT3, HMGCR, IGF1R, KDR, MIF, MMP9, PPARA, PRKCD, SRC, XDH 2.89398
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP3, MMP9 2.8839
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AR, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD1, ESR1, ESR2, F2, F3, FABP4, FLT3, HMGCR, IGF1R, MET, MIF, MMP9, PIM1, PPARA, PRKCD, PTAFR, SRC, TRPV1, XDH 2.8839
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.8828
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP3, MMP9 2.87998
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, CA2, CA7, CYP19A1, DRD1, F2, HCAR2, HMGCR, MIF, MMP12, MMP9, PPARA, PRKCD, PTAFR, SRC, TRPV1 2.86927
[BP] GO:0009115 None AOX1, XDH 2.86927
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP3, MMP9 2.86286
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HCAR2, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP3, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PRKCD, PTAFR, PTGES, SRC, TRPV1, TYR, XDH 2.86048
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, CA12, CA2, CA7, DRD1, ESR1, F2, FABP3, FABP4, FLT3, MET, SRC, TRPV1 2.84964
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.80423
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APP, AR, AURKB, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HCAR2, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP3, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PRKCD, PTAFR, SRC, TRPV1, XDH 2.79187
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, PRKCD, SRC 2.79038
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTAFR, PTGES, SRC 2.77993
[BP] GO:0031324 negative regulation of cellular metabolic process APP, AR, AURKB, CSNK2A1, CYP2D6, ESR1, ESR2, ESRRA, F2, FABP4, HMGCR, IGF1R, MET, MIF, MMP12, MMP3, MMP9, NR3C1, PPARA, PRKCD, SRC, TRPV1, XDH 2.75197
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, MIF, PIM1, PPARA, PTGES, TYR 2.674
[BP] GO:0030335 positive regulation of cell migration APP, DRD1, F3, IGF1R, KDR, MET, MMP9, PTAFR, SRC 2.64882
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.63667
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, MIF, PIM1, PPARA, PTGES, TYR 2.60007
[BP] GO:0051098 regulation of binding APP, AURKB, CYP2D6, MET, MMP9, PPARA, PRKCD, SRC 2.60007
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, F2, MMP3, PRKCD, TRPV1, XDH 2.55954
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, DRD1, ESR1, ESR2, HMGCR, IGF1R, MET, MIF, MMP12, MMP9, PRKCD, SRC, XDH 2.55269
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, IGF1R, PPARA, PRKCD, SRC, TRPV1 2.55256
[BP] GO:2000147 positive regulation of cell motility APP, DRD1, F3, IGF1R, KDR, MET, MMP9, PTAFR, SRC 2.54431
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, DRD1, ESR1, ESR2, HMGCR, IGF1R, MET, MIF, MMP12, MMP9, PRKCD, SRC, XDH 2.54316
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, F2, MMP12, PPARA, PRKCD 2.54109
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, AR, ESRRB, F2, FLT3, HMGCR, KDR, MIF, MMP9, PRKCD, SRC, XDH 2.50907
[BP] GO:0010676 None ESRRB, PPARA, PTAFR, SRC 2.49918
[BP] GO:0050994 None ADORA1, HCAR2, PPARA, PRKCD 2.49918
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, FABP3, PPARA, TRPV1 2.49689
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, AR, FLT3, HMGCR, IGF1R, KDR, MIF, PRKCD, SRC, XDH 2.47338
[BP] GO:0051272 positive regulation of cellular component movement APP, DRD1, F3, IGF1R, KDR, MET, MMP9, PTAFR, SRC 2.4675
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.46365
[BP] GO:0060748 None AR, PGR 2.46234
[BP] GO:0046110 None AOX1, XDH 2.46234
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.46234
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, CYP1B1, PRKCD, SRC 2.45394
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, F2, IGF1R, KDR, MET, MMP12, NR3C1, PGR, PPARA, PTAFR, SRC 2.43291
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, MAOA 2.41876
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.40898
[BP] GO:0035588 None ADORA1, ADORA3, PTAFR 2.38437
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, F2, KDR, MET, MIF, MMP1, MMP12, MMP9, PRKCD, PTAFR, SRC 2.38413
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APP, AXL, CA2, CA3, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, F2, MIF, MMP2, MMP3, MMP9, PPARA, PRKCD, PTAFR, PTGES, SRC, TRPV1 2.38385
[BP] GO:0043269 regulation of ion transport ADORA1, APP, CA2, CA7, DRD1, F2, MIF, MMP9, PRKCD, PTAFR 2.38315
[BP] GO:0040017 positive regulation of locomotion APP, DRD1, F3, IGF1R, KDR, MET, MMP9, PTAFR, SRC 2.37467
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2D6, MAOA 2.36011
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 2.36011
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, F2, PPARA, PRKCD 2.34724
[BP] GO:0022414 reproductive process AKR1B1, APP, AR, AXL, CYP19A1, CYP1A1, DRD1, ESR1, ESRRB, HSD17B2, MMP2, MMP9, PGR, PTAFR, SRC 2.33556
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, MET, TRPV1 2.29764
[BP] GO:0006810 None ACHE, ADORA1, ALOX5, APP, AR, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, F2, FABP3, MIF, MMP12, MMP9, PPARA, PRKCD, PTAFR, SRC, TRPV1, XDH 2.28404
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.27979
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, PRKCD 2.27527
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, PRKCD 2.26998
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, AR, DRD1, F2, FABP4, FLT3, HMGCR, IGF1R, KDR, MIF, MMP9, PRKCD, SRC, XDH 2.26363
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, APP, AR, AURKB, CA9, CSNK2A1, CYP1B1, CYP2D6, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP3, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PRKCD, PTAFR, SRC, TRPV1, XDH 2.26363
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1 2.2581
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, AR, FLT3, HMGCR, KDR, MIF, SRC, XDH 2.24744
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.2325
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, AURKB, CSNK2A1, DRD1, ESR1, F2, F3, FABP4, FLT3, HMGCR, IGF1R, MIF, MMP9, PRKCD, PTAFR, SRC, XDH 2.22807
[BP] GO:1902532 negative regulation of intracellular signal transduction ESR1, HMGCR, IGF1R, MET, MIF, MMP9, PRKCD, SRC, XDH 2.22027
[BP] GO:0006145 None AOX1, XDH 2.22027
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.22027
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.22027
[BP] GO:0051179 None ACHE, ADORA1, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, ESR1, F2, FABP3, MIF, MMP12, MMP9, PPARA, PRKCD, PTAFR, SRC, TRPV1, XDH 2.20015
[BP] GO:0051234 None ACHE, ADORA1, ALOX5, APP, AR, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, F2, FABP3, MIF, MMP12, MMP9, PPARA, PRKCD, PTAFR, SRC, TRPV1, XDH 2.1979
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.19095
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTAFR 2.16582
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CSNK2A1, DRD1, FLT3, IGF1R, KDR, MET, PIM1, PRKCD, SRC 2.16582
[BP] GO:0010942 positive regulation of cell death CYP1B1, F3, HCAR2, HMGCR, MMP3, MMP9, PRKCD, SRC, TRPV1, XDH 2.13733
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, CA12, CA2, CA7, DRD1, ESR1, F2, FABP3, FABP4, MET, TRPV1 2.13733
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, AR, F2, FLT3, HMGCR, KDR, MIF, MMP9, PRKCD, SRC, XDH 2.13065
[BP] GO:0045913 None ESRRB, PPARA, PTAFR, SRC 2.13065
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR 2.10746
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, F2, F3, FLT3, IGF1R, KDR, MET, MIF, MMP2, MMP9, PRKCD, PTAFR, SRC, TRPV1 2.10715
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, F2, HCAR2, HMGCR, MIF, MMP12, PRKCD, SRC 2.08114
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, AR, CSNK2A1, ESR1, F2, F3, FLT3, HMGCR, KDR, MIF, MMP9, PRKCD, PTAFR, SRC, XDH 2.07869
[BP] GO:0010605 negative regulation of macromolecule metabolic process APP, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, F2, FABP4, HMGCR, IGF1R, KDR, MIF, MMP12, MMP9, NR3C1, PGR, PPARA, PRKCD, SRC, TRPV1, XDH 2.06874
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APP, AR, AURKB, CA9, CSNK2A1, CYP1A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HCAR2, HMGCR, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PRKCD, PTAFR, SRC, TRPV1, XDH 2.06182
[BP] GO:0048545 response to steroid hormone AR, CA2, FLT3, NR3C1, PTAFR, SRC 2.05835
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CYP1A1, DRD1, ESR1, PGR, SRC 2.05184
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, PRKCD, SRC 2.05114
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGES 2.04351
[BP] GO:0010641 None F3, SRC 2.04295
[BP] GO:0035587 None ADORA1, ADORA3, PTAFR 2.02767
[BP] GO:0016572 histone phosphorylation AURKB, DRD1, PRKCD 2.02767
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, AXL, F2, MIF, PTAFR, PTGES, TRPV1 2.01707
[BP] GO:0071383 None AR, FLT3, NR3C1, SRC 2.01707
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, F2, KDR, MIF, MMP1, MMP12, MMP9, PRKCD, SRC 2.00206
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, F2, HCAR2 2.00206
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.46412
[CC] GO:0044432 endoplasmic reticulum part APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, F2, FLT3, HMGCR, HSD11B1, HSD17B2, NR3C2, PTGES 3.08169
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AR, AURKB, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, ESR1, ESR2, F2, FABP3, FABP4, FLT3, HMGCR, HSD11B1, HSD17B1, HSD17B2, KDR, MAOA, MIF, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PRKCD, PTAFR, PTGES, SRC, TRPV1, TYR, XDH 3.08169
[CC] GO:0005789 endoplasmic reticulum membrane CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, HMGCR, HSD11B1, HSD17B2, NR3C2, PTGES 2.8059
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, ESR1, F2, F3, FLT3, HCAR2, HMGCR, HSD11B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP2, NR3C2, PGR, PIM1, PRKCD, PTAFR, PTGES, SRC, TRPV1, TYR 2.14412
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP3, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, TYR, XDH 24.0963
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 20.2663
[MF] GO:0043167 ion binding ACHE, ALOX5, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP3, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PRKCD, PTAFR, PTGES, SRC, TRPV1, TYR, XDH 15.9101
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.847
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP3, MMP9, NR3C1, NR3C2, PGR, PPARA 12.4292
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.5212
[MF] GO:0043169 cation binding ACHE, ALOX5, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, MMP1, MMP12, MMP2, MMP3, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PRKCD, TRPV1, TYR, XDH 10.5931
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, F2, F3, FLT3, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP3, MMP9, PIM1, PRKCD, PTGES, SRC, TYR, XDH 9.66887
[MF] GO:0046872 metal ion binding ALOX5, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F2, MMP1, MMP12, MMP2, MMP3, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PRKCD, TRPV1, TYR, XDH 9.42962
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA 9.25861
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 8.52662
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, NR3C1, NR3C2, PGR 7.83342
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HMGCR, HSD11B1, HSD17B1, HSD17B2, MAOA, TYR, XDH 7.5566
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 7.54824
[MF] GO:0008289 lipid binding AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, HSD17B1, NR3C1, NR3C2, PGR, PPARA, PTAFR, TRPV1 7.1901
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 7.06898
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, XDH 6.9409
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PGR, PPARA 6.74967
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PGR, PPARA 6.74967
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, PPARA, PTAFR, TRPV1 6.55838
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 6.25446
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, PPARA, PTAFR, TRPV1 5.70018
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HMGCR, HSD17B1, PTGES, SRC, XDH 5.50043
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 5.48104
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, PPARA, PTAFR, TRPV1 5.48104
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, SRC 5.35428
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HMGCR, HSD11B1, HSD17B1, HSD17B2, XDH 5.18351
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, SRC 5.13956
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, DRD1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, PPARA, PTAFR, TRPV1 5.01827
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 4.78951
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6 4.57087
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, DRD1, FLT3, IGF1R, KDR, MET, PIM1, PPARA, PRKCD, SRC, TRPV1 3.78191
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.43797
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, PRKCD, SRC 3.34985
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD17B1, HSD17B2 3.28948
[MF] GO:0017171 serine hydrolase activity ACHE, F2, F3, MMP1, MMP12, MMP2, MMP3, MMP9 3.11144
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.01086
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NR3C1 2.87626
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.86927
[MF] GO:0008389 None CYP2A13, CYP2A6 2.86927
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.75449
[MF] GO:0004252 None F2, F3, MMP1, MMP12, MMP2, MMP3, MMP9 2.60007
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, CSNK2A1, ESR1, ESR2, FLT3, HMGCR, IGF1R, KDR, MET, MIF, MMP9, PGR, TRPV1, TYR, XDH 2.52517
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.45394
[MF] GO:0004222 metalloendopeptidase activity MMP1, MMP12, MMP2, MMP3, MMP9 2.34724
[MF] GO:0008236 None F2, F3, MMP1, MMP12, MMP2, MMP3, MMP9 2.34724
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.22027
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PRKCD, SRC 2.17216
[MF] GO:0035586 None ADORA1, ADORA3, PTAFR 2.14412
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.0604
[MF] GO:0019899 enzyme binding APP, AR, AURKB, CYP1A1, CYP1A2, CYP2A6, ESR1, ESR2, ESRRB, F3, HMGCR, MET, MIF, NR3C1, PGR, PPARA, PRKCD, PTAFR, SRC 2.0604
[MF] GO:0043168 anion binding AOX1, APP, AURKB, AXL, CSNK2A1, F2, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, MET, PIM1, PRKCD, PTAFR, PTGES, SRC, TRPV1, XDH 2.04351
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.04295


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 21.4104
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.7118
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 7.4184
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 6.8265
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 5.2571
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, PRKCD, MMP9, ESR1, ESR2 4.8049
Metabolic pathways_Homo sapiens_hsa01100 MAOA, AKR1B1, HMGCR, TYR, CYP19A1, HSD11B1, CYP2A6, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, XDH, PTGES 4.4743
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.1879
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.2296
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP2D6, CYP1A2, AOX1 4.3582
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, PTAFR, ADORA1, TRPV1, DRD1, NR3C1, F2 3.454
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, MIF, TYR 4.2296
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.9846
Pathways in cancer_Homo sapiens_hsa05200 AR, FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.6315
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.2476
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.0816
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PRKCD, PIM1, F3 2.6315
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.1739
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP3, MMP9, MET, IGF1R 2.6315
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAOA, CYP2D6, ALOX5 2.4825
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.9987
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, PRKCD 1.7455
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, PRKCD, TRPV1 1.6876
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1, DRD1, PPARA 1.6876
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.6853
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.6476
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.3963
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.5027
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC, PRKCD 1.3963
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET 1.2687
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.2954
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.2921
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.0351
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2687
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, DRD1 1.2316
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2747
Prostate cancer_Homo sapiens_hsa05215 AR, IGF1R 1.0651
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2316
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9136
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.212
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PGR, IGF1R 1.021
TNF signaling pathway_Homo sapiens_hsa04668 MMP3, MMP9 0.9462
Insulin resistance_Homo sapiens_hsa04931 PRKCD, PPARA 0.9462
Cocaine addiction_Homo sapiens_hsa05030 MAOA, DRD1 1.3945
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.0637
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2289
Gap junction_Homo sapiens_hsa04540 SRC, DRD1 1.0659
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGES 1.2655
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.4104
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.145
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, MMP3 1.0644
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.1879
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR 1.212
Complement and coagulation cascades_Homo sapiens_hsa04610 F2, F3 1.1434
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9136
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9136
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.908
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.8035
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, DRD1 0.8665
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 0.8897
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.8145
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, IGF1R 0.7385
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6876
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.7665
Calcium signaling pathway_Homo sapiens_hsa04020 PTAFR, DRD1 0.6992
Alcoholism_Homo sapiens_hsa05034 MAOA, DRD1 0.6992
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.7383
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC, PRKCD 0.6857
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, F2 0.624
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5904
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8496
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.3029
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3018
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3354
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3266
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3353
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6623
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3468
Parkinson's disease_Homo sapiens_hsa05012 DRD1 0.3919
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3748
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3633
Measles_Homo sapiens_hsa05162 CSNK2A1 0.3992
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3919
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4032
Platelet activation_Homo sapiens_hsa04611 SRC 0.4219
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4032
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PRKCD 0.4239
Axon guidance_Homo sapiens_hsa04360 MET 0.4117
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4399
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4239
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCD 0.4239
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.4629
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCD 0.4765
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4661
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4835
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4661
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4765
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4765
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4765
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4835
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4765
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4835
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4835
Peroxisome_Homo sapiens_hsa04146 XDH 0.4919
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5311
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5478
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5672
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5659
Glioma_Homo sapiens_hsa05214 IGF1R 0.5672
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5672
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5792
Shigellosis_Homo sapiens_hsa05131 SRC 0.5672
Staphylococcus aureus infection_Homo sapiens_hsa05150 PTAFR 0.6014
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA, MIF 2.0756
Malaria_Homo sapiens_hsa05144 MET 0.6392
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.6364
Type II diabetes mellitus_Homo sapiens_hsa04930 PRKCD 0.6423
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6423
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6423
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 NR3C2 0.6992
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6944
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.786
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.786
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8035
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.8333
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8633
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.24


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)