TCM Prescription: Yu Jin Yin Xie Tablet



Prescription Description
Prescription IDTCMF691
Pinyin NameYu Jin Yin Xie Pian 
Chinese Name郁金银屑片
English NameYu Jin Yin Xie Tablet
Function Description摄领疮
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationSkin
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1673 Gentiana macrophylla 秦艽 TCMH1673 ITSAO2245-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH1920 Acorus tatarinowii 石菖蒲 TCMH1920 ITSAI4409-14
TCMH717 Phellodendron amurense 关黄柏 TCMH717 ITSAM1586-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH544 Curcuma aeruginosa 莪术 TCMH544 ITSAN2146-14
TCMH2329 Realgar 雄黄 TCMH2329
TCMH1406 Strychnos nux-vomica 马钱子粉 TCMH1406 PPBI045-16
TCMH2570 Spina gleditsiae 皂角刺 TCMH2570
TCMH2073 Prunus persica 桃仁 TCMH2073 ITSAN1047-14
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH1753 Boswellia carterii 乳香 TCMH1753
TCMH1552 Sal ammoniaci 硇砂 TCMH1552
TCMH2342 Natrii sulfas exsiccatus 玄明粉 TCMH2342
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH2129 Eupolyphaga sinensis 土鳖虫 TCMH2129 GBMIN33972-13
TCMH1678 Indigo naturalis 青黛 TCMH1678
TCMH1511 Momordica cochinchinensis 木鳖子 TCMH1511 ITSAJ4256-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT594 PTAFR Platelet activating factor receptor GPCR P25105
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT904 PGR Progesterone receptor Nuclear receptor P06401
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1305 Salmonella enteritidis
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, KDR, MAOA, MET, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS1, PTGS2, SLC1A1, SRC, XDH 15.7408
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AR, AXL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, FABP3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, HTR1B, HTR5A, IDO1, IGF1R, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTAFR, PTGES, PTGS2, RELA, RORC, SRC, TYR 15.7408
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.7408
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.7408
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IDO1, IGF1R, KDR, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTAFR, PTGES, PTGS2, RELA, RORC, SRC, TYR 13.2827
[BP] GO:0007187 None ADORA1, CNR1, CNR2, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 13.2184
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, ESR1, FABP3, FABP4, FUT7, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MET, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2 13.2005
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, HTR1B, HTR5A, IDO1, IGF1R, KDR, MMP2, NR3C1, PIK3CA, PPARA, PTAFR, PTGES, PTGS2, RELA, RORC, SRC, TYR 12.9098
[BP] GO:0033993 response to lipid ALPL, AR, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, IDO1, NR3C1, PTAFR, PTGES, PTGS2, RELA, RORC, SRC, TYR 12.7287
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FUT7, HMGCR, HSD17B3, HTR2B, HTR2C, IDO1, PIK3CA, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, TYR, XDH 11.9347
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, AR, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, FLT3, HSD11B2, HTR1B, HTR5A, NR3C1, PTAFR, PTGES, PTGS2, RELA, RORC, SRC, TYR 11.7064
[BP] GO:0007193 None ADORA1, DRD2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 11.501
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8, HTR1B, HTR2A, PTGS2 11.1917
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.9266
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CYP1B1, DRD2, F3, FLT3, GRM1, HMGCR, HTR2A, HTR2B, HTR2C, HTR6, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 10.5521
[BP] GO:0007188 None ADORA1, CNR1, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 10.4263
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FLT3, GRM1, HCAR2, HMGCR, HTR2A, HTR2B, HTR2C, HTR6, KDR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 10.2522
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FLT3, GRM1, HCAR2, HMGCR, HTR2A, HTR2B, HTR2C, HTR6, KDR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 10.2135
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, ESR1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2C 10.202
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 10.114
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.114
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, PTGS1, PTGS2 10.082
[BP] GO:0099536 None CNR1, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, SLC1A1 10.0273
[BP] GO:0099537 None CNR1, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, SLC1A1 10.0273
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, DRD1, DRD2, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1B, HTR2A, PTGS2 10.0125
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, DRD1, DRD2, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1B, HTR2A, PTGS2 10.0125
[BP] GO:0097756 None ADORA1, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 9.85523
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD2, ESR1, F3, FABP3, FLT3, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, IDO1, IGF1R, KDR, MAP2K1, MMP2, MMP9, PGR, PIM1, PTAFR, PTGES, PTGS1, PTGS2, RELA, SRC, XDH 9.72545
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, F3, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IDO1, IGF1R, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTAFR, PTGS2, RELA, RORC, SRC, TYR 9.51164
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 9.25308
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AR, AXL, BCL2, CA1, CA2, CACNA1C, CNR1, CNR2, CSNK2A1, CYP1B1, DRD1, DRD2, ESR1, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP2, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTPN1, RELA, RORC, SRC 9.18723
[BP] GO:0007268 None DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, SLC1A1 9.15297
[BP] GO:0098916 None DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, SLC1A1 9.15297
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, FABP3, HMGCR, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KDR, NR3C1, PTAFR, PTGS2, RELA, SRC 9.09611
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 9.09467
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IDO1, MAOA, NQO2, PTGS1, PTGS2, TYR, XDH 9.05731
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SRC, XDH 9.05434
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, PTGS1, PTGS2 9.04835
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SRC, XDH 8.97088
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.82925
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, FABP3, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SRC, XDH 8.75114
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, FABP3, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SRC, XDH 8.75114
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, PTGS1, PTGS2 8.75114
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, APP, CA2, CNR1, CNR2, DRD1, DRD2, ESR1, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB, PTAFR, SRC 8.73007
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA6, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IDO1, IGF1R, KDR, MAP2K1, MAP3K7, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SRC, TYR 8.64161
[BP] GO:0007154 None ADORA1, AR, AXL, BCL2, CACNA1C, CNR1, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PGR, PTGS2, SLC1A1 8.57811
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, FABP3, FLT3, GRM5, HSD11B2, HTR1B, HTR5A, IGF1R, MMP2, NR3C1, PPARA, PTAFR, PTGS2, RELA, SRC 8.27458
[BP] GO:0003018 None ADORA1, DRD1, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTAFR, PTGS2, SRC 8.17154
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CACNA1C, CNR1, DRD1, DRD2, HCAR2, HMGCR, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PTGS2, SRC 8.0499
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, HMGCR, HSD17B3, HTR1A, MAOA, PTAFR, TYR 8.02359
[BP] GO:0097746 None ADORA1, DRD1, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTAFR, PTGS2 7.98481
[BP] GO:0035296 None ADORA1, DRD1, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTAFR, PTGS2 7.98481
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESR1, F3, FLT3, GRM1, HMGCR, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 7.92741
[BP] GO:0023052 None ADORA1, AR, CACNA1C, CNR1, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PGR, SLC1A1 7.9232
[BP] GO:0007267 None ADORA1, AR, CNR1, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PGR, SLC1A1 7.8983
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DRD2, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 7.87039
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.87007
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, F3, FLT3, GRM1, HMGCR, HTR2A, HTR2B, HTR2C, HTR6, KDR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 7.87007
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, HCAR2, HMGCR, HTR2B, IDO1, IGF1R, KDR, MAP2K1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RELA, SRC, XDH 7.83278
[BP] GO:0050880 None ADORA1, DRD1, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTAFR, PTGS2 7.75619
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, HCAR2, HMGCR, HTR2B, IDO1, IGF1R, KDR, MAP2K1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC, XDH 7.75619
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, FABP3, FABP4, FUT7, HMGCR, MET, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2 7.7509
[BP] GO:0035150 None ADORA1, DRD1, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTAFR, PTGS2 7.73187
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, F3, FABP3, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SRC, XDH 7.68736
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, PTGS1, PTGS2 7.68505
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, AR, DRD2, FLT3, GRM1, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC, XDH 7.64126
[BP] GO:0009725 response to hormone AKR1B1, ALPL, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, NR3C1, PPARA, PTAFR, PTGS2, RELA, SRC 7.57986
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DRD2, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 7.55488
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 7.4085
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, PTGES, PTGS2, RELA, SRC 7.4085
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, HMGCR, HTR1B, HTR1D, KDR, RELA, SRC 7.35002
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2, DRD2, HTR1B 7.33131
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, HCAR2, HMGCR, HTR2B, IDO1, IGF1R, KDR, MAP2K1, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RELA, SRC, XDH 7.30324
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, DRD2, F3, FABP4, FLT3, GRM1, HMGCR, HTR2A, HTR2B, HTR2C, HTR6, IDO1, KDR, MAP2K1, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, RELA, SRC, XDH 7.29096
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, GRIK5, GRM5, HTR1B, IGF1R, KDR, MMP2, NR3C1, PIK3CA, PTAFR, PTGS2, RELA, RORC, SRC 7.228
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2 7.13745
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, PTGS1, PTGS2 7.08082
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, BCL2, CDC25B, CSNK2A1, DRD2, ESR1, F3, FLT3, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, MMP2, MMP9, PIM1, PTAFR, PTGS2, RELA 6.9657
[BP] GO:0003013 None ADORA1, DRD1, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTAFR, PTGS2, SRC 6.93426
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 6.91037
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, HTR2A, HTR2B, HTR2C, KDR, SRC 6.87319
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, GRIK5, GRM5, HCAR2, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MET, MMP9, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SRC 6.86918
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.81283
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, FABP4, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.80632
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, GRIK5, GRM5, HTR1B, IGF1R, KDR, MMP2, MMP9, NR3C1, PIK3CA, PTAFR, PTGS2, RELA, RORC, SRC 6.79269
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SLC1A1, SRC, XDH 6.683
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, FABP4, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 6.67566
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, DRD1, DRD2, HTR1B, HTR2A, PTGS2 6.66269
[BP] GO:0050795 None ADORA1, CNR1, DRD2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 6.66269
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCL2, CA2, FLT3, HSD11B2, HTR1B, NR3C1, PTAFR, PTGS2, RELA, SRC 6.64963
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DRD2, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, RELA, SRC, XDH 6.63907
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, DRD1, DRD2, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, HTR2A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB 6.494
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, DRD1, DRD2, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HTR2A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB, SRC 6.27733
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, AR, DRD2, FLT3, GRM1, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC, XDH 6.2234
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGES, PTGS1, PTGS2 6.21032
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2, HSD17B3 6.15521
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HCAR2, HMGCR, HTR2A, HTR2B, HTR2C, PPARA, PTGS2, RORC, SRC 6.11555
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, GRM1, HMGCR, HSD11B2, HTR1B, HTR2A, HTR2B, MMP2, PPARA, PTAFR, PTGS2, RELA, SRC, TYR 6.0415
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 5.97806
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DRD2, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.95984
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CYP19A1, DRD1, DRD2, GRIK5, GRM5, HCAR2, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MAP2K1, MMP9, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, SRC 5.95926
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CYP1B1, DRD1, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, NR3C1, PIK3CA, PTAFR, PTGS2, RELA, RORC, SRC 5.91342
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DRD2, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SRC, XDH 5.9058
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, CNR1, CNR2, DRD1, DRD2, FABP3, FLT3, GRM5, HSD11B2, HTR1B, IGF1R, MMP2, PPARA, PTAFR, PTGS2, RELA, SRC, TYR 5.85472
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HMGCR, HTR2B, IDO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC 5.74683
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HMGCR, HTR2B, IDO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, RELA, SRC 5.68076
[BP] GO:0007610 None APP, BCL2, CNR1, DRD1, DRD2, GRM1, GRM5, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IDO1, PPARA, PTGS2 5.66713
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 5.61246
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, DRD1, DRD2, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, SRC, XDH 5.58872
[BP] GO:0003008 None ADORA1, AKR1B1, APP, BCL2, CNR1, CNR2, CYP1B1, DRD1, DRD2, GRM1, GRM5, GRM8, HMGCR, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA, PTAFR, PTGS2, SRC, TYR 5.50802
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, MAP3K7, NR3C1, PGR, PIM1, PPARA, RELA, RORC, SRC 5.50257
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA, SLC1A1 5.40211
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, AR, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, NR3C1, PTAFR, PTGS2, RORC, SRC 5.40155
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, CNR1, CNR2, DRD1, DRD2, FABP3, FLT3, GRM5, HSD11B2, HTR1B, IGF1R, MMP2, PPARA, PTAFR, PTGS2, RELA, SRC, TYR 5.35962
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HTR1B, IGF1R, KDR, MAP2K1, MAP3K7, MMP2, MMP9, NR3C1, PIK3CA, PTAFR, PTGS2, PTPN1, RELA, RORC, SRC 5.2714
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DRD1, DRD2, FABP4, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 5.2464
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, F3, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR2B, HTR2C, IDO1, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SRC, TYR, XDH 5.23946
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SRC, XDH 5.14894
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, HMGCR, HTR2B, IDO1, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, RELA, SRC 5.10077
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.10018
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, SRC 5.05055
[BP] GO:0008217 None ADORA1, AR, CNR1, DRD2, HSD11B2, PPARA, PTAFR, PTGS1, PTGS2 5.02805
[BP] GO:0043269 regulation of ion transport ADORA1, APP, BCL2, CA2, CA7, CACNA1C, CNR1, DRD1, DRD2, GRM5, HTR1A, HTR1B, HTR2A, MMP9, PTAFR, PTGS2 4.99856
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 4.99339
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 4.99339
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC 4.98984
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DRD2, FABP4, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 4.91955
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, HTR1B, NR3C1, PTAFR, PTGS2, SRC 4.89563
[BP] GO:0048513 animal organ development ACHE, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD11B1, HSD17B2, HSD17B3, KDR, MAP2K1, PIK3CA, PPARA, RELA, SRC, TYR 4.84867
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, HTR1B, MMP2, MMP9, PTAFR, PTGS2 4.82458
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CBR1, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, FABP4, FLT3, FUT7, HMGCR, HSD11B1, HSD17B2, HSD17B3, HTR2A, HTR2B, HTR5A, KDR, MAP2K1, MET, MMP2, MMP9, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, RORC, SRC, TYR 4.82458
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, NQO2, PTGS1, RORC 4.81755
[BP] GO:0042391 None ADORA1, APP, BCL2, CACNA1C, CNR1, CNR2, DRD1, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 4.80394
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR2B, HTR2C, IDO1, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SRC, TYR, XDH 4.80394
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5, PTAFR 4.80018
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, HTR1A, MAOA, TYR 4.75937
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, IDO1, PPARA, PTGES, PTGS1, PTGS2 4.74608
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, DRD2, F3, HCAR2, HMGCR, HTR2A, HTR2B, IDO1, KDR, MAP2K1, MAP3K7, MET, MMP9, PIM1, PTAFR, PTGS2, RELA, SLC1A1, SRC 4.7354
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, PTPN1, SRC 4.7311
[BP] GO:0006939 None DRD1, DRD2, HTR1D, HTR2A, HTR2B, HTR7 4.7311
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, GRM1, HMGCR, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC 4.70564
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, PTGES, PTGS2, RELA, SRC 4.68896
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, DRD1, DRD2, ESR1, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SRC, XDH 4.68154
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SRC, XDH 4.64686
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, ESR1, GRIK5, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 4.63543
[BP] GO:0019371 None CBR1, PTGES, PTGS1, PTGS2 4.63318
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, HTR1B, KDR, NR3C1, PTAFR, PTGS2, RELA, SRC 4.62457
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, PTGS2, SRC 4.60099
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, DRD1, ESR1, HSD11B2, HSD17B2, HSD17B3, IDO1, MAP2K1, MMP2, MMP9, PGR, PTAFR, PTGS2, SRC 4.52123
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DRD2, FABP4, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 4.51187
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, ESR1, FABP3, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB 4.51187
[BP] GO:0007200 None DRD1, DRD2, ESR1, GRM5, HTR2A, HTR2B, HTR2C 4.47361
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, PTGES, PTGS2, RELA, SRC 4.43529
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 4.43529
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, FLT3, HMGCR, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, PTAFR, PTGS2, PTPN1, SRC, XDH 4.42637
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, FLT3, GRM1, GRM5, HTR2A, HTR2B, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 4.4259
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CACNA1C, CNR1, CYP19A1, DRD2, GRIK5, HCAR2, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, PTAFR, SRC 4.41502
[BP] GO:0044283 None AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD17B3, IDO1, PTAFR, PTGES, PTGS1, PTGS2 4.40498
[BP] GO:0090066 None ADORA1, ALOX15, DRD1, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTAFR, PTGS2 4.37299
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CBR1, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, F3, FABP3, FABP4, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SLC1A1, SRC, TYR, XDH 4.37119
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, DRD1, DRD2, ESR1, F3, FABP4, HMGCR, IDO1, KDR, MAP2K1, MET, PPARA, PTGS2, RELA 4.32844
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 4.30786
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.28211
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SRC, XDH 4.2793
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, DRD1, DRD2, FABP3, GRIA2, GRIA4, GRIK5, HTR2A, HTR2B, HTR2C, PPARA, SLC1A1 4.24949
[BP] GO:0006874 cellular calcium ion homeostasis APP, BCL2, CACNA1C, DRD1, DRD2, ESR1, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB 4.2457
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.21466
[BP] GO:0051967 None ADORA1, DRD2, HTR1B, HTR2A 4.21466
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, DRD2, HTR1B, HTR2A, MMP9, PTGS2 4.20192
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, F3, FABP4, FLT3, GRM1, HMGCR, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGS2, PTPN1, RELA, SRC, XDH 4.19953
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB, PTAFR 4.17876
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, DRD1, DRD2, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, SRC, XDH 4.17071
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA, SLC1A1 4.16149
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9, PTGES, PTGS2 4.16071
[BP] GO:0032845 None ADORA1, BCL2, DRD2, HMGCR, HTR2A, HTR2B, HTR2C, SRC 4.14574
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTAFR, PTPN1, RELA, SRC 4.14271
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, FLT3, GRM1, GRM5, HTR2A, HTR2B, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 4.14257
[BP] GO:0055074 calcium ion homeostasis APP, BCL2, CACNA1C, DRD1, DRD2, ESR1, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB 4.13216
[BP] GO:0009410 None CNR1, CNR2, DRD1, DRD2, HTR1B, NR3C1, PTAFR, RELA 4.11139
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DRD2, FABP4, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 4.10841
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, FLT3, HMGCR, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, PTAFR, PTGS2, PTPN1, SRC, XDH 4.08419
[BP] GO:0072503 cellular divalent inorganic cation homeostasis APP, BCL2, CACNA1C, DRD1, DRD2, ESR1, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB 4.08176
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB, PTAFR 4.08163
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, ESR1, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB 4.07337
[BP] GO:0051046 None ACHE, ADORA1, CACNA1C, CNR1, CYP19A1, DRD2, GRIK5, HCAR2, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, PTAFR, SRC 4.0588
[BP] GO:0046883 regulation of hormone secretion ADORA1, CACNA1C, CNR1, CYP19A1, DRD2, HCAR2, HMGCR, HTR1A, HTR2A, HTR2C 4.05274
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, FLT3, GRM1, HTR2A, HTR2B, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC 4.03958
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.00107
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SLC1A1, SRC, XDH 3.99838
[BP] GO:0030003 cellular cation homeostasis APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, ESR1, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB 3.99447
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGES, PTGS1, PTGS2 3.97101
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 3.94728
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR, HSD17B3, IDO1 3.90442
[BP] GO:0072507 divalent inorganic cation homeostasis APP, BCL2, CACNA1C, DRD1, DRD2, ESR1, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB 3.88041
[BP] GO:0006873 cellular ion homeostasis APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, ESR1, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB 3.87855
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, DRD2, ESR1, FABP4, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 3.85202
[BP] GO:1900543 None DRD2, GRM3, GRM8, HTR1B, HTR1E, PPARA 3.83761
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AR, AURKB, BCL2, CDC25B, DRD2, ESR1, F3, FLT3, GRM1, GRM5, HTR2A, HTR2B, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTAFR, PTPN1, RELA, SRC, XDH 3.83602
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX15, CYP19A1, CYP3A4, HMGCR, HSD17B3, PTAFR, TYR 3.80837
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC 3.80837
[BP] GO:0045980 None DRD2, GRM3, GRM8, HTR1B, HTR1E, PPARA 3.80837
[BP] GO:0014821 None DRD1, DRD2, HTR1D, HTR2B 3.80288
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC 3.79729
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, ESR1, HTR7, PGR, PPARA, RORC, SRC 3.7828
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, AR, DRD1, ESR1, FLT3, GRM5, HTR1B, IGF1R, MMP2, NR3C1, PTAFR, PTGS2, RELA, SRC 3.77673
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, FLT3, HSD11B1, HSD17B2, HSD17B3, HTR5A, KDR, MAP2K1, MMP9, PGR, PIK3CA, PIM1, PPARA, PTGS2, RELA, RORC, SRC, TYR 3.76992
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, FLT3, GRM1, GRM5, HTR2A, HTR2B, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 3.76443
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, CNR2, PIK3CA, PIK3CB, PTAFR, PTGES, PTGS1, PTGS2, RELA 3.72444
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 3.72366
[BP] GO:0045776 None ADORA1, CNR1, DRD2, PPARA, PTAFR 3.72138
[BP] GO:0019725 cellular homeostasis APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, ESR1, GRIK5, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 3.70989
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, DRD1, DRD2, HCAR2, PIK3CB, PTGS2 3.70693
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, MET, PIK3CA 3.70147
[BP] GO:0051952 None ADORA1, CNR1, DRD1, DRD2, HTR1B, HTR2A 3.6925
[BP] GO:0032229 None ADORA1, CNR2, HTR1B 3.68768
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, HTR1D, IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC 3.67244
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, RELA, SRC, XDH 3.66977
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CACNA1C, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC 3.656
[BP] GO:0007568 aging AURKB, BCL2, CNR1, CYP1A1, HMGCR, HTR2A, MAP2K1, PTGS2, RELA 3.64167
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1, DRD2, PTGS2 3.63962
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD1, DRD2, IDO1, MAOA 3.63651
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, HSD11B2, HTR1A, HTR2C, IDO1, MAP2K1, MAP3K7, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, RELA, SRC 3.57193
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, NR3C1, PTAFR, RELA, SRC 3.54116
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CNR1, CNR2, CYP19A1, DRD2, ESR1, F3, FABP4, HMGCR, IDO1, IGF1R, MAP2K1, MAP3K7, MET, MMP2, PPARA, PTGS2, PTPN1, RELA, SRC, XDH 3.52806
[BP] GO:0055080 cation homeostasis APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, ESR1, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB 3.52806
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, HTR1B, MMP2, MMP9, PTAFR, PTGS2 3.48628
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC 3.48149
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, HTR1A, MAOA 3.47731
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.47091
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.47091
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.47091
[BP] GO:0030815 None DRD2, GRM3, GRM8, HTR1B, HTR1E 3.46388
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, FABP3, FABP4, GRM3, GRM8, HCAR2, HMGCR, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IDO1, IGF1R, KDR, MAP2K1, MET, MMP9, NR3C1, PGR, PIK3CA, PIM1, PPARA, PTGES, PTGS2, PTPN1, RELA, RORC, SRC, XDH 3.41818
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, FLT3, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIM1, SRC 3.41161
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AR, AXL, BCL2, CA2, CACNA1C, CNR1, CYP1B1, DRD2, ESR1, F3, GRM1, HCAR2, HMGCR, HTR2A, HTR2B, HTR2C, IDO1, KDR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIM1, PTAFR, PTGS2, RELA, SLC1A1, SRC, XDH 3.40995
[BP] GO:0030800 None DRD2, GRM3, GRM8, HTR1B, HTR1E 3.38376
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DRD1, GRM5, HTR1B, IGF1R, MMP2, PTAFR, PTGS2, RELA, SRC 3.37843
[BP] GO:0060359 None CNR1, DRD1, DRD2, HTR1B, PTAFR, RELA 3.36092
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTAFR, PTGES, PTGS2, RELA, SRC 3.36031
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, MAP2K1, MET, PIK3CB, PIM1, SRC, TYR 3.35467
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.34038
[BP] GO:2001023 None CNR1, DRD1, DRD2, HTR1B, HTR2A, MET 3.33934
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, GRIK5, HTR1A, MAOA, PTGS2, SLC1A1 3.3343
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AR, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DRD2, ESR1, FABP4, GRM3, GRM8, HCAR2, HMGCR, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MAP2K1, MET, MMP9, NR3C1, PGR, PIK3CA, PPARA, PTGS2, PTPN1, RELA, RORC, SRC, XDH 3.33112
[BP] GO:0051588 None DRD1, DRD2, GRIK5, HTR1A, HTR1B, HTR2C 3.31542
[BP] GO:0006875 cellular metal ion homeostasis APP, BCL2, CACNA1C, DRD1, DRD2, ESR1, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB 3.30829
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, FABP3, FABP4, GRM3, GRM8, HMGCR, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IDO1, IGF1R, KDR, MAP2K1, MET, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PTGES, PTGS2, PTPN1, RELA, RORC, SRC, XDH 3.29938
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, FLT3, HSD11B2, NR3C1, PTAFR, PTGS2 3.29101
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SRC 3.29101
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, IDO1, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR 3.28906
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, DRD1, DRD2, GRM5, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PTAFR, PTPN1, RELA, SRC 3.27236
[BP] GO:0033555 multicellular organismal response to stress BCL2, DRD1, HTR1A, HTR2C, IDO1 3.24788
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, CNR1, HCAR2, HTR2B, MET, PIK3CA, PPARA, RELA 3.24569
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, BCL2, CDC25B, DRD2, ESR1, F3, FLT3, GRM1, GRM5, HTR2A, HTR2B, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTAFR, PTPN1, SRC, XDH 3.22186
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.22186
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SRC 3.19848
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, FLT3, GRM1, HMGCR, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC 3.16963
[BP] GO:0048608 reproductive structure development AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSD17B3, MAP2K1, SRC 3.16229
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, RELA, SRC 3.1564
[BP] GO:0050890 None ADORA1, APP, CNR1, DRD1, DRD2, GRM5, HMGCR, HTR2A, PTGS2 3.14196
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, DRD2, ESR1, FABP4, IDO1, MAP3K7, MMP2, PPARA, PTGS2, PTPN1, RELA, SRC 3.12837
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, ESR1, HSD17B2, HSD17B3, MAP2K1, PGR, PTGS2, SRC 3.11355
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1, HSD17B3 3.10453
[BP] GO:0014059 None CNR1, DRD2, HTR1B, HTR2A 3.10453
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DRD1, GRM5, HTR1B, IGF1R, MMP2, PTAFR, PTGS2, RELA, SRC 3.10401
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GRM5, HSD11B2, IGF1R, PPARA, PTGS2, RELA, SRC 3.10401
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, FLT3, GRM1, HTR2A, HTR2B, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC 3.0839
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, F3, MET, PIK3CA, PIK3CB, SRC, XDH 3.08057
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, HMGCR, HSD11B2, PTGS2, RELA, SRC, TYR 3.07273
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, ESR1, HMGCR, IGF1R, MET, MMP9, PTGS2, PTPN1, RELA, SRC, XDH 3.07273
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CNR1, CYP1B1, F3, GRIK5, HCAR2, HMGCR, IDO1, MMP9, PIK3CB, PTGS2, SRC, XDH 3.06546
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, PTGES, PTGS1, PTGS2 3.0533
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CNR1, CYP1B1, F3, GRIK5, HCAR2, HMGCR, IDO1, MMP9, PIK3CB, PTGS2, SRC, XDH 3.02319
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PTAFR, PTGS2, PTPN1, RELA, SRC, XDH 3.02319
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.01859
[BP] GO:0051480 regulation of cytosolic calcium ion concentration CACNA1C, DRD1, DRD2, ESR1, GRM1, GRM5, HTR2A, HTR2B, HTR2C 3.00608
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD1, DRD2, HMGCR, PTGS2, RELA, TYR 3.00608
[BP] GO:0006952 defense response ADORA1, ADORA3, ALOX15, APP, AXL, BCL2, CNR2, DRD1, HTR1A, HTR2C, PIK3CA, PIK3CB, PTAFR, PTGES, PTGS1, PTGS2, RELA, SRC 3.0053
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 3.0053
[BP] GO:0002209 None BCL2, DRD1, HTR1A, HTR2C 3.0053
[BP] GO:0001662 None BCL2, DRD1, HTR1A, HTR2C 3.0053
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, DRD1, F3, IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC 2.99801
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, DRD1, DRD2, FUT7, HTR2B, HTR6, KDR, MAP2K1, MET, MMP1, MMP9, PIK3CA, PIK3CB, PTAFR, SRC 2.98635
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A 2.95189
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, NR3C1, NR3C2, PGR, PPARA, RORC 2.95133
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SRC 2.94668
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 2.9394
[BP] GO:0060402 None CACNA1C, DRD2, HTR2A, HTR2B, HTR2C 2.9394
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, RELA, SRC 2.93493
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, RELA, SRC 2.93493
[BP] GO:0051094 positive regulation of developmental process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, DRD2, F3, HMGCR, HTR2A, HTR2C, IDO1, KDR, MAP2K1, PIM1, PTGS2, RELA, SRC 2.92609
[BP] GO:0042596 None BCL2, DRD1, HTR1A, HTR2C 2.91095
[BP] GO:0002031 None DRD2, HTR1B, HTR2B 2.91095
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.91095
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, FLT3, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, SRC 2.91009
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESR1, F3, FLT3, GRM1, HMGCR, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, RELA, SRC, XDH 2.89176
[BP] GO:0055065 metal ion homeostasis APP, BCL2, CACNA1C, DRD1, DRD2, ESR1, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB 2.88499
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, DRD1, F3, IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC 2.87806
[BP] GO:0010863 positive regulation of phospholipase C activity ESR1, HTR2A, HTR2B, PTAFR 2.8625
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, BCL2, CNR2, DRD1, DRD2, ESR1, HMGCR, HTR1B, HTR2A, IGF1R, MET, MMP9, PTGS2, PTPN1, RELA, SRC, XDH 2.83873
[BP] GO:0051282 None CACNA1C, DRD1, DRD2, HTR2A, HTR2B, HTR2C 2.83719
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, IDO1, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR 2.83575
[BP] GO:0007208 None HTR2A, HTR2C 2.83132
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, BCL2, CNR2, DRD1, DRD2, ESR1, HMGCR, HTR1B, HTR2A, IGF1R, MET, MMP9, PTGS2, PTPN1, RELA, SRC, XDH 2.82924
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, BCL2, CA2, CNR1, CNR2, CYP19A1, DRD2, ESR1, HCAR2, IDO1, MAP3K7, MMP2, PIK3CA, PIK3CB, PTAFR, PTPN1, RELA, SRC 2.82574
[BP] GO:1900542 None DRD1, DRD2, GRM3, GRM8, HTR1B, HTR1E, HTR2A, PPARA 2.81337
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.80709
[BP] GO:0007611 None APP, CNR1, DRD1, DRD2, GRM5, HMGCR, HTR2A, PTGS2 2.80239
[BP] GO:0030814 None DRD1, DRD2, GRM3, GRM8, HTR1B, HTR1E 2.78631
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, DRD1, F3, IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC 2.78482
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, HTR6 2.77774
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APP, AR, AURKB, BCL2, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SRC, XDH 2.77774
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, IDO1, PPARA, PTGS2, RELA 2.77621
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, IDO1, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR 2.76116
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, APP, AR, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SRC, XDH 2.76116
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, RELA, SRC 2.76061
[BP] GO:0010942 positive regulation of cell death BCL2, CNR1, CYP1B1, F3, GRIK5, HCAR2, HMGCR, IDO1, MMP9, PIK3CB, PTGS2, SRC, XDH 2.74472
[BP] GO:0006140 None DRD1, DRD2, GRM3, GRM8, HTR1B, HTR1E, HTR2A, PPARA 2.73736
[BP] GO:1900274 regulation of phospholipase C activity ESR1, HTR2A, HTR2B, PTAFR 2.73736
[BP] GO:0032147 activation of protein kinase activity ADORA1, DRD2, GRM1, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PTPN1, SRC 2.73525
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.7352
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, MAP2K1, PIK3CA, RELA, TYR 2.72804
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.71659
[BP] GO:0001516 None PTGES, PTGS1, PTGS2 2.71659
[BP] GO:0046457 None PTGES, PTGS1, PTGS2 2.71659
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DRD2, PPARA 2.696
[BP] GO:0007626 None APP, DRD1, DRD2, GRM1, GRM5, HTR2C, IDO1 2.696
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, DRD1, F3, IGF1R, KDR, MET, MMP9, PTAFR, PTGS2, SRC 2.66737
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration CACNA1C, DRD1, DRD2, ESR1, GRM1, HTR2A, HTR2B, HTR2C 2.66219
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.65663
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, HMGCR, HSD11B2, PTGS2, RELA, SRC, TYR 2.64147
[BP] GO:0060401 None CACNA1C, DRD2, HTR2A, HTR2B, HTR2C 2.63529
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR 2.63258
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.62399
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 2.61101
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 2.60053
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 2.5894
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, NR3C1, PGR, SRC 2.58709
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 2.56062
[BP] GO:1901570 None ALOX15, ALOX5, PTGES, PTGS1, PTGS2 2.53726
[BP] GO:0035094 response to nicotine BCL2, CNR1, DRD2, RELA 2.53682
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, AR, BCL2, CNR1, CNR2, CYP19A1, DRD1, DRD2, ESR1, HMGCR, IGF1R, MET, MMP9, PPARA, PTGS2, PTPN1, RELA, SRC, XDH 2.5331
[BP] GO:0007584 response to nutrient ALPL, CNR1, CYP1A1, HMGCR, PTGS2, RELA, TYR 2.50825
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, BCL2, CYP1B1, DRD2, FABP3, IDO1, MAP2K1, PTGES, PTGS2, XDH 2.50358
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, IDO1, PIK3CB 2.49387
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5, PTAFR 2.49387
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, PTGS2, RELA, TYR 2.49387
[BP] GO:0003012 None ADORA1, DRD1, DRD2, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA 2.49256
[BP] GO:0009894 regulation of catabolic process ADORA1, BCL2, CNR1, CSNK2A1, HCAR2, HTR2A, HTR2B, KDR, MAP3K7, MET, PIK3CA, PIK3CB, PPARA, PTPN1, RELA 2.49161
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, DRD1, DRD2, FUT7, HTR2B, HTR6, KDR, MAP2K1, MMP1, MMP9, PIK3CA, PIK3CB, SRC 2.47663
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.47406
[BP] GO:0001816 cytokine production APP, FABP4, IDO1, PTAFR, PTGS2 2.47363
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CACNA1C, CNR1, DRD2, HCAR2, HMGCR, HTR2B, HTR2C, PTGS2, PTPN1, SRC 2.47213
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, MAOA 2.46939
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, MAOA 2.46939
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.46733
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.46733
[BP] GO:0032225 None DRD1, DRD2, PTGS2 2.46733
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.46733
[BP] GO:0044057 None ADORA1, ADORA3, CACNA1C, DRD2, GRM1, HCAR2, HTR2A, HTR2C, PTAFR, PTGS2, SLC1A1 2.46145
[BP] GO:0007612 None APP, DRD1, DRD2, GRM5, HMGCR, PTGS2 2.45829
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.43813
[BP] GO:0030818 None DRD2, GRM3, GRM8, HTR1B 2.43751
[BP] GO:0099566 None GRM1, GRM5 2.43124
[BP] GO:0060748 None AR, PGR 2.43124
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.43124
[BP] GO:0033602 None CNR1, DRD2 2.43124
[BP] GO:0051283 None DRD2, HTR2A, HTR2B, HTR2C 2.40835
[BP] GO:0051209 None DRD2, HTR2A, HTR2B, HTR2C 2.40835
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, NR3C1, NR3C2, PGR, PPARA, RORC 2.37659
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 2.37659
[BP] GO:0071396 cellular response to lipid AR, AXL, ESR1, FLT3, NR3C1, PTAFR, RELA, RORC, SRC 2.37659
[BP] GO:0030803 None DRD2, GRM3, GRM8, HTR1B 2.37525
[BP] GO:0030799 None DRD1, DRD2, GRM3, GRM8, HTR1B, HTR1E 2.37157
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, DRD1, DRD2, FUT7, HTR2B, HTR6, KDR, MMP1, MMP9, PIK3CA, PIK3CB, SRC 2.36927
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, APP, AR, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1B1, DRD1, DRD2, ESR1, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SRC, XDH 2.36174
[BP] GO:0050433 None CNR1, DRD2, HTR1B, HTR2A 2.34205
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, F3, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR2B, HTR2C, IDO1, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SRC, TYR, XDH 2.31004
[BP] GO:0008542 None APP, DRD1, DRD2, HMGCR 2.30874
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, MMP9, PTGS2, PTPN1, RELA, SRC 2.30702
[BP] GO:0002791 None ACHE, ADORA1, CACNA1C, CNR1, DRD2, HCAR2, HMGCR, HTR2B, HTR2C, SRC 2.30231
[BP] GO:1903522 None ADORA1, ADORA3, CACNA1C, DRD2, HTR2A, PTAFR, PTGS2, SLC1A1 2.29963
[BP] GO:0072330 monocarboxylic acid biosynthetic process ALOX15, CYP1A1, IDO1, PTGES, PTGS1, PTGS2 2.28269
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.28269
[BP] GO:1900372 None DRD2, GRM3, GRM8, HTR1B 2.28168
[BP] GO:0030809 None DRD2, GRM3, GRM8, HTR1B 2.28168
[BP] GO:0010518 positive regulation of phospholipase activity ESR1, HTR2A, HTR2B, PTAFR 2.28168
[BP] GO:0006936 None DRD1, DRD2, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA 2.2771
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CNR1, CYP1A1, DRD1, ESR1, PGR, PTGS2, SRC 2.27212
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.27142
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, HMGCR, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 2.26902
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, HMGCR, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 2.25741
[BP] GO:0007631 None APP, DRD1, DRD2, HTR1B, HTR2C 2.24268
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.24268
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F3, MET, PIK3CA, PIK3CB, SRC 2.23351
[BP] GO:0030100 regulation of endocytosis ALOX15, APP, AXL, DRD2, PIK3CB, PTPN1, SRC 2.22562
[BP] GO:0003014 None ADORA1, AKR1B1, BCL2, DRD2, HSD11B2 2.22538
[BP] GO:0035588 None ADORA1, ADORA3, PTAFR 2.2122
[BP] GO:0048148 None DRD1, DRD2, HTR2A 2.2122
[BP] GO:0048167 None ADORA1, APP, DRD1, DRD2, GRM5, PTGS2 2.20683
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PPARA 2.19633
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CACNA1C, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SRC, XDH 2.19504
[BP] GO:0030817 None DRD1, DRD2, GRM3, GRM8, HTR1B 2.1884
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.17762
[BP] GO:0038171 None CNR1, CNR2 2.17762
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.17762
[BP] GO:0014827 None HTR1D, HTR2B 2.17762
[BP] GO:0007632 None APP, DRD1, DRD2, HMGCR 2.17429
[BP] GO:0019233 None CNR1, CNR2, GRM1, PTGS2 2.17429
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, DRD1, DRD2, ESR1, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MET, NR3C1, PGR, PPARA, PTAFR, PTGS2, RELA, RORC, SRC 2.16856
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.16066
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 2.13495
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, IDO1, MAOA, MMP1, MMP2, MMP9, PIK3CB, SRC, XDH 2.13137
[BP] GO:0031623 None ACHE, DRD2, HTR1B, HTR2B 2.11572
[BP] GO:0050877 None ADORA1, APP, CNR1, CNR2, CYP1B1, DRD1, DRD2, GRM1, GRM5, GRM8, HMGCR, HTR2A, PTGS2, TYR 2.10903
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ALOX15, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, ESR1, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGS2, PTPN1, RELA, RORC, SRC, XDH 2.10784
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 2.10784
[BP] GO:0050730 None ADORA1, APP, FLT3, GRM5, HTR2A, PTPN1, SRC 2.10784
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9 2.10784
[BP] GO:0050995 None ADORA1, CNR1, HCAR2 2.10784
[BP] GO:0060627 regulation of vesicle-mediated transport ALOX15, APP, AXL, DRD2, GRIK5, MAP2K1, PIK3CB, PTAFR, PTPN1, SRC 2.09811
[BP] GO:0001819 positive regulation of cytokine production CYP1B1, DRD2, HTR2B, IDO1, MAP3K7, PTAFR, PTGS2, RELA, SRC 2.09159
[BP] GO:0007613 None CNR1, DRD1, DRD2, HTR2A, PTGS2 2.07065
[BP] GO:0019932 second-messenger-mediated signaling CACNA1C, DRD1, DRD2, GRM5, HTR2B, HTR5A, KDR 2.06781
[BP] GO:0097553 None DRD2, HTR2A, HTR2B, HTR2C 2.06781
[BP] GO:0072347 None CNR1, DRD2, HTR1B, RELA 2.06781
[BP] GO:0051953 None ADORA1, CNR1, DRD2 2.05698
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.05698
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.05698
[BP] GO:0046890 None FABP3, HMGCR, HTR2A, HTR2B, HTR2C, PTGS2 2.04665
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.03892
[BP] GO:0045936 None DRD2, FABP4, GRM3, GRM8, HMGCR, HTR1B, HTR1E, IGF1R, PPARA, PTPN1, XDH 2.03416
[BP] GO:0051051 negative regulation of transport ADORA1, APP, BCL2, CNR1, DRD2, HMGCR, HTR1B, HTR2A, MMP9, PTGS2 2.03056
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.03029
[BP] GO:0010563 None DRD2, FABP4, GRM3, GRM8, HMGCR, HTR1B, HTR1E, IGF1R, PPARA, PTPN1, XDH 2.03029
[BP] GO:0010517 regulation of phospholipase activity ESR1, HTR2A, HTR2B, PTAFR 2.0178
[BP] GO:0032098 None HTR2C, HTR4, PPARA 2.00787
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.00787
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, PTAFR, PTGES, PTGS2, RELA, SRC 2.00057
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, F3, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP2, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TYR 10.0125
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, CNR1, CNR2, DRD1, DRD2, F3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTAFR, SLC1A1 9.49563
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, F3, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MET, NR3C2, PIK3CA, PIK3CB, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, SLC1A1, SRC, TYR 8.73007
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, CSNK2A1, DRD1, DRD2, ESR1, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTAFR, PTPN1, SLC1A1, SRC 8.65948
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, CNR1, CNR2, DRD1, DRD2, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTAFR, SLC1A1 8.58781
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, DRD1, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTAFR, PTGS2, SLC1A1, SRC 7.82452
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, GRIA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HSD17B3, NR3C2, PTGES, PTGS1, PTGS2 4.67691
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, FLT3, GRIA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HSD17B3, NR3C2, PTGES, PTGS1, PTGS2, PTPN1 4.30786
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CNR1, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, MET, PTGS2, SLC1A1, SRC 4.30786
[CC] GO:0043005 None ADORA1, APP, CA2, CNR1, CNR2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, PTGS2, SRC 4.26402
[CC] GO:0042734 None CNR1, GRIK5, GRM1, GRM3, GRM5, GRM8 4.14574
[CC] GO:0120025 None ADORA1, AKR1B1, APP, CA2, CNR1, CNR2, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, HTR6, PIK3CA, PTGS2, SRC 3.70558
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, CA2, CNR1, CNR2, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, HTR6, PIK3CA, PTGS2, SRC 3.3654
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA4, CA9, CACNA1C, CNR1, CNR2, CYP3A4, DRD1, DRD2, ESR1, F3, FLT3, FUT7, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MET, PTAFR, PTGES, SLC1A1, TYR 3.36092
[CC] GO:0097458 None ADORA1, APP, CA2, CACNA1C, CNR1, CNR2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, HTR5A, IDO1, PTGS1, PTGS2, SRC 3.30829
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.29938
[CC] GO:0014069 None ADORA1, CACNA1C, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 3.25268
[CC] GO:0099572 None ADORA1, CACNA1C, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 3.25268
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AR, AURKB, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CACNA1C, CBR1, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, FABP3, FABP4, FLT3, FUT7, GRIA2, GRIA4, GRIK5, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR2A, HTR4, HTR5A, IDO1, KDR, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, RELA, SRC, TYR, XDH 3.12837
[CC] GO:0044456 None ACHE, ADORA1, APP, CACNA1C, CNR1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC 3.10401
[CC] GO:0016021 None ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA9, CACNA1C, CNR1, CNR2, CYP3A4, DRD1, DRD2, ESR1, F3, FLT3, FUT7, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MET, PTAFR, PTGES, SLC1A1, TYR 3.00835
[CC] GO:0043197 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 2.75318
[CC] GO:0044309 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 2.71958
[CC] GO:0005783 None ADORA1, APP, BCL2, CA4, CYP19A1, FLT3, GRIK5, HMGCR, HSD17B3, HTR5A, KDR, MAP2K1, PTGS2, PTPN1, XDH 2.37659
[CC] GO:0097060 None CNR1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 2.28168
[CC] GO:0098794 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 2.23351
[MF] GO:0030594 None DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.5338
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 15.7408
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.7408
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.7408
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 15.7408
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 15.7408
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, CNR1, CNR2, DRD1, DRD2, ESR1, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, PPARA, PTAFR, RORC 15.7408
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, MMP1, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, TYR, XDH 14.5982
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, CNR1, CNR2, DRD1, DRD2, ESR1, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MAP2K1, MAP3K7, MET, NR3C1, NR3C2, PGR, PPARA, PTAFR, RORC 14.2413
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, CNR1, CNR2, DRD1, DRD2, ESR1, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, PPARA, PTAFR, RORC 14.0116
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SLC1A1, SRC, TYR, XDH 13.7913
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, CNR1, CNR2, DRD1, DRD2, ESR1, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, PPARA, PTAFR, RORC 13.5983
[MF] GO:0099528 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 13.3034
[MF] GO:0008227 None DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 12.9995
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 11.7064
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, DRD1, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTAFR 11.1519
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, DRD1, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTAFR 11.1519
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IDO1, MAOA, NQO2, PTGS1, PTGS2, TYR, XDH 10.7953
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 10.2135
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.0273
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, MAP3K7, MMP1, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, TYR, XDH 9.93838
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 8.77415
[MF] GO:0005496 steroid binding AR, CYP3A4, ESR1, HSD11B2, HSD17B1, NR3C1, NR3C2, PGR, RORC, SHBG 8.23252
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 7.9232
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, IDO1, PTGS1, PTGS2, SRC 7.87007
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.82985
[MF] GO:0004930 None ADORA1, ADORA3, CNR1, CNR2, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PTAFR 7.81978
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, IDO1, PTGS1, PTGS2, SRC 7.57986
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD11B2, HSD17B1, IDO1, NQO2, PTGES, PTGS1, PTGS2, SRC, XDH 7.13745
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, MMP1, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PPARA, PTPN1, RORC 6.87319
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 6.6041
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, XDH 6.48335
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, F3, FLT3, FUT7, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, PTPN1, SRC, TYR, XDH 6.18404
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, DRD1, DRD2, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MAP2K1, MAP3K7, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC 6.04318
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PTGS1, PTGS2, TYR 5.96389
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH 5.84926
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 5.81909
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, NR3C1, NR3C2, PGR, PPARA, RORC 5.53379
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR 5.3822
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 5.30934
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, CYP3A4, ESR1, F3, FABP3, FABP4, HSD11B2, HSD17B1, NR3C1, NR3C2, PGR, PPARA, PTAFR, RORC, SHBG 5.12921
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 4.87508
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.58621
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NQO2, NR3C1, SHBG 4.53464
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.43529
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 4.13515
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, IDO1, MAP3K7, MMP1, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, TYR, XDH 4.13515
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, PGR, PPARA, RORC 3.42187
[MF] GO:0004879 nuclear receptor activity AR, ESR1, PGR, PPARA, RORC 3.42187
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, IDO1, PTGS2 3.22186
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, IDO1, PTGS2 3.15928
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.14874
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 2.99801
[MF] GO:0097159 organic cyclic compound binding ADORA1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, FLT3, HMGCR, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, IGF1R, KDR, MAP2K1, MAP3K7, MET, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RELA, RORC, SHBG, SRC, XDH 2.94402
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 2.93493
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 2.91095
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.83132
[MF] GO:0003845 None HSD11B1, HSD11B2 2.83132
[MF] GO:0008389 None CYP2A13, CYP2A6 2.83132
[MF] GO:0071886 None HTR2A, HTR2C 2.83132
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 2.66737
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.56148
[MF] GO:0003674 molecular_function ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CBR1, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, F3, FABP3, FABP4, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IDO1, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTAFR, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SHBG, SLC1A1, SRC, TYR, XDH 2.51535
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.43124
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.43124
[MF] GO:0004949 None CNR1, CNR2 2.43124
[MF] GO:0099583 None GRM1, GRM5 2.43124
[MF] GO:0051213 dioxygenase activity ALOX15, ALOX5, IDO1, PTGS1, PTGS2 2.33557
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.27142
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.27142
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIM1, SRC 2.24268
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.17762
[MF] GO:0004971 None GRIA2, GRIA4 2.17762
[MF] GO:0005497 None AR, SHBG 2.17762
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.17762
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PIM1, SRC 2.10784
[MF] GO:1901363 heterocyclic compound binding ADORA1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, FLT3, HMGCR, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, IGF1R, KDR, MAP2K1, MAP3K7, MET, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RELA, RORC, SRC, XDH 2.10784
[MF] GO:0042802 identical protein binding ACHE, APP, BCL2, CSNK2A1, DRD2, ESR1, FLT3, GRIK5, HMGCR, IGF1R, KDR, MAP3K7, MET, MMP9, NQO2, PGR, PTGS2, RELA, TYR, XDH 2.0905


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRIA2, GRIK5, PTAFR, HTR2B, HTR2C, HTR2A, NR3C1, HTR4, GRM1, GRM3, HTR6, GRM5, HTR7, CNR2, CNR1, ADORA3, GRM8, ADORA1, DRD1, DRD2, GRIA4, HTR1E, HTR1D, HTR1A, HTR1B, HTR5A 23.2511
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAP2K1, HTR1E, MAOA, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, CACNA1C, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, ALOX5 21.6463
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, MAP2K1, HTR1E, HTR1D, HTR1A, HTR1B, CACNA1C, PIK3CB, HTR4, RELA, HCAR2, HTR6, PIK3CA, ADORA1, DRD1, DRD2, PPARA, GRIA4 15.6227
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 17.1951
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP3A4, CYP19A1 11.0606
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, GRM5, HTR7, PTAFR, HTR2B, HTR2C, CACNA1C, HTR2A, DRD1, HTR5A, HTR4, GRM1 8.5546
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.4953
Gap junction_Homo sapiens_hsa04540 GRM5, MAP2K1, SRC, HTR2B, HTR2C, HTR2A, DRD1, DRD2, GRM1 7.9846
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MAOA, ALOX15, HSD17B3, AKR1B1, HMGCR, PTGS2, TYR, CYP3A4, CYP19A1, PTGS1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, PTGES, IDO1 7.0713
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 8.2128
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, CACNA1C, GRM1, GRIA4 7.0713
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 7.2921
Pathways in cancer_Homo sapiens_hsa05200 MAP2K1, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, RELA, IGF1R, AR, PIK3CA, BCL2, MET 6.0067
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 6.0636
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, GRM1 6.3468
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, PIK3CA, BCL2, PIK3CB, RELA, IGF1R 5.5049
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3, RELA 5.2598
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, PIK3CA, FLT3, PIM1, PIK3CB, RELA 5.4441
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 5.4671
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, PIK3CA, SRC, CNR1, KDR, PIK3CB, DRD2, MET, IGF1R 5.1008
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, MAOA, DRD1, DRD2, RELA 5.7698
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, PIK3CA, SRC, KDR, PIK3CB, PTGS2 5.2885
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, CNR1, CACNA1C, PTGS2, GRM1, GRIA4 5.2598
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, PIK3CA, PIK3CB, PTGS2, MMP9, MAP3K7, RELA 5.0616
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, PTGS2, PTGES, PTGS1 5.2672
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, PIK3CA, SRC, PIK3CB, ESR1, RELA 4.9974
Focal adhesion_Homo sapiens_hsa04510 MAP2K1, PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 4.3984
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB, RELA 4.8837
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, PIK3CA, SRC, BCL2, PIK3CB, MMP9, RELA 4.3717
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, MAP2K1, PIK3CA, GRM8, PIK3CB, GRM1 4.3984
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B, CACNA1C, GRM1 4.6983
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MAP3K7, MET, IGF1R 4.9638
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, HTR2B, HTR2C, PIK3CB, HTR2A 4.3419
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, HTR7, PIK3CA, KDR, PIK3CB, MET, RELA, IGF1R 4.1049
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 4.105
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, PIK3CA, PGR, PIK3CB, CDC25B, IGF1R 4.3419
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, MAP2K1, PIK3CA, BCL2, CACNA1C, PIK3CB 4.0847
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, PIK3CA, BCL2, PIK3CB, RELA, IGF1R 4.2291
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, MAP3K7, RELA 3.9694
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, MAOA, CACNA1C, DRD1, DRD2, GRIA4 3.7757
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9 4.9638
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, CYP1B1, IDO1 4.9974
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, PIK3CA, SRC, CACNA1C, PIK3CB, PTGS2 3.3142
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, PIK3CA, ADORA3, ADORA1, CACNA1C, PIK3CB 3.207
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, MAOA, CACNA1C, DRD1, GRIA4 4.0729
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 MAP2K1, PIK3CA, KDR, BCL2, PIK3CB, MET, RELA, IGF1R 3.0409
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, MAP2K1, CACNA1C, GRM1 4.0847
Melanoma_Homo sapiens_hsa05218 MAP2K1, PIK3CA, PIK3CB, MET, IGF1R 3.9694
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, PIK3CA, FLT3, PIK3CB, MET 4.0729
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.2294
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.207
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2, RELA 3.5948
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA, RELA 3.1583
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2, MAP3K7, RELA 3.4417
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 MAP2K1, PIK3CA, SRC, PIK3CB, ESR1 3.0409
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, PIK3CA, BCL2, PIK3CB, RELA 3.0302
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, MAP3K7, RELA 2.8904
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, HMGCR, MAP3K7, IGF1R 2.9821
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 2.8904
Apoptosis_Homo sapiens_hsa04210 MAP2K1, PIK3CA, BCL2, PIK3CB, RELA 2.7986
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, MAP3K7, RELA 2.8441
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, PIK3CA, PIK3CB, GRM1, IGF1R 2.8824
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.3462
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.209
Glioma_Homo sapiens_hsa05214 MAP2K1, PIK3CA, PIK3CB, IGF1R 3.0409
Long-term depression_Homo sapiens_hsa04730 GRIA2, MAP2K1, GRM1, IGF1R 3.138
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2311
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, PIK3CA, SRC, PIK3CB, RELA 2.2847
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.24
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1, PIK3CA, BCL2, PIK3CB 3.0906
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, PIK3CA, PIK3CB, RELA 3.0302
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.1752
Axon guidance_Homo sapiens_hsa04360 MET 0.322
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.3271
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, MMP2, CACNA1C 2.594
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, PIK3CA, PIK3CB, RELA 2.9076
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, RELA, IGF1R 2.547
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, PGR, IGF1R 2.1674
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, PIK3CA, PIK3CB, MET 3.0302
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, RELA 2.0561
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, PIK3CA, PIK3CB, RELA 2.9076
ErbB signaling pathway_Homo sapiens_hsa04012 MAP2K1, PIK3CA, SRC, PIK3CB 2.6611
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, MAP2K1, PIK3CA, PIK3CB 2.0026
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, CACNA1C, MAP3K7, RELA, CDC25B 1.7989
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.2224
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, PIK3CA, PIK3CB, IGF1R 1.9792
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3915
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 1.8401
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA, RELA 1.9038
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, CACNA1C, PIK3CB 1.93
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, CYP3A4 3.0409
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4072
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4062
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.7462
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.6192
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.2244
Influenza A_Homo sapiens_hsa05164 MAP2K1, PIK3CA, PIK3CB, RELA 1.7095
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, PIK3CB, RELA 0.762
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4233
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.7201
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4233
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA, DRD1, DRD2 1.6847
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.4233
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7289
Salmonella infection_Homo sapiens_hsa05132 RELA 0.4264
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4233
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4233
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.4279
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 MAP2K1, PIK3CA, SRC, PIK3CB 1.4634
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, MAP3K7 0.7201
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB, RELA 1.5167
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.0441
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP1A2, CYP3A4 2.9821
Peroxisome_Homo sapiens_hsa04146 XDH 0.4338
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2, RELA 1.0808
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4371
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4338
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.8283
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.4453
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4433
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1, PIK3CA, PIK3CB 1.3396
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 0.8044
Pertussis_Homo sapiens_hsa05133 RELA 0.4567
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.9821
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4588
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.4588
Melanogenesis_Homo sapiens_hsa04916 MAP2K1, TYR 0.927
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1, PIK3CA, PIK3CB 1.7104
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 0.9385
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB, RELA 1.6124
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB, RELA 1.6461
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1, PIK3CA, PIK3CB 1.6424
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, CACNA1C, GRIA4 1.6938
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.9876
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.5064
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB, NR3C2 3.8002
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.0094
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1, PIK3CA, PIK3CB 2.0319
Staphylococcus aureus infection_Homo sapiens_hsa05150 PTAFR 0.5535
Leishmaniasis_Homo sapiens_hsa05140 PTGS2, MAP3K7, RELA 1.9658
Legionellosis_Homo sapiens_hsa05134 RELA 0.5575
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, CYP3A4 1.9889
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.1681
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.0915
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, RELA 2.0319
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.1604
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.1681
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.5911
Malaria_Homo sapiens_hsa05144 MET 0.596
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.2244
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.2683
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6092
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.2192
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1, PIK3CA, PIK3CB 2.2361
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC, RELA 1.2192
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1, PIK3CA, PIK3CB 2.318
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.3018
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.278
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, CACNA1C, PIK3CB 2.4076
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.3837
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6666
Prion diseases_Homo sapiens_hsa05020 MAP2K1 0.7165
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.7165
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.7655
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.4558
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7476
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.4778
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1 0.7913
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.5669
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8005
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7577
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7913
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.762
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 2.9772
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, TYR 1.6578
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.712
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.8268
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6424
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8595
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9658
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.9566
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0279
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.068


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)