TCM Prescription: Fu Fang Shuang Hua Tablets



Prescription Description
Prescription IDTCMF6898
Pinyin NameFu Fang Shuang Hua Pian
Chinese Name复方双花片
English NameFu Fang Shuang Hua Tablets
Function Description清热解毒, 利咽消肿。用于风热外感, 风热乳蛾。证见发热, 微恶风, 头痛, 鼻塞流涕, 咽红而痛或咽喉干燥灼痛
IndicationsTonsillitis disorder, Common cold
Disease ICD-11 Category SC93 [Tonsillitis disorder (TM1), 乳蛾 (TM1) ];
CA00 [Acute nasopharyngitis, 急性鼻咽炎 ];
Human Tissues Associated with IndicationLung, blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1127 Lonicera japonica 金银花 TCMH1127 ITSAI3881-14
TCMH1272 Forsythia suspensa 连翘 TCMH1272 ITSAJ4444-14
TCMH298 Andrographis paniculata 穿心莲 TCMH298 ITSAO3492-14
TCMH127 Isatis indigotica 板蓝根 TCMH127 KJ765825
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT575 PLA2G2A Phospholipase A2 group IIA Hydrolase P14555
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT904 PGR Progesterone receptor Nuclear receptor P06401


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1208 Escherichia coli K12
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1241 Human rhinovirus 14
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1333 Human rhinovirus 1A
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APP, AR, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, GSK3B, HSD17B2, IDO1, IGF1R, MMP2, MMP9, NR3C1, PTGS2, RORC, SRC, TYR 8.13537
[BP] GO:0010033 response to organic substance AKR1B1, APP, AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, GSK3B, HSD17B2, IDO1, IGF1R, KDR, MMP2, NR3C1, PTGS2, RORC, SRC, TYR 7.21333
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, TYR, XDH 6.89455
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FUT7, IDO1, PIM1, PTGS2, TYR, XDH 6.8627
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PTGS2 6.8627
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, CDC25B, CSNK2A1, CYP1B1, FABP3, FLT3, IDO1, IGF1R, KDR, MMP12, MMP2, MMP9, PGR, PIM1, PTGS2, SRC, XDH 6.43788
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GSK3B, HCAR2, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 6.43788
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GSK3B, HCAR2, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 6.43788
[BP] GO:0033993 response to lipid AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, IDO1, NR3C1, PTGS2, RORC, SRC, TYR 6.43788
[BP] GO:0042221 response to chemical AKR1B1, APP, AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, GSK3B, HSD17B2, IDO1, IGF1R, KDR, MMP2, MMP9, NR3C1, PTGS2, RORC, SRC, TYR 6.43788
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GSK3B, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, PTPN1, SRC 6.39345
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GSK3B, HCAR2, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, PTPN1, SRC, XDH 6.33068
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, DHFR 6.30994
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, FABP3, FABP4, FLT3, GSK3B, HCAR2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, XDH 6.29661
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, GSK3B, HSD17B1, HSD17B2, IDO1, PTGS2, TYR, XDH 6.29661
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FLT3, GSK3B, HCAR2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, XDH 6.28835
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GSK3B, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, PTPN1, SRC 5.978
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP2, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, TYR, XDH 5.978
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GSK3B, HCAR2, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, PTPN1, SRC, XDH 5.9236
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.91723
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC 5.88397
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GSK3B, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, PTPN1, SRC 5.74743
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GSK3B, HCAR2, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, PTPN1, SRC, XDH 5.74743
[BP] GO:0014070 response to organic cyclic compound APP, AR, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FLT3, NR3C1, PTGS2, RORC, SRC, TYR 5.70842
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 5.5928
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GSK3B, IDO1, MMP1, MMP12, MMP2, MMP9, SRC, XDH 5.20482
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2 5.09522
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, GSK3B, IGF1R, KDR, MMP2, MMP9, NR3C1, PTGS2, RORC, SRC 5.06389
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DHFR, FABP3, FABP4, FLT3, GSK3B, HCAR2, HSD17B1, HSD17B2, KDR, MET, PTGS2, SRC, XDH 4.83085
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP4, FLT3, FUT7, GSK3B, HSD17B2, KDR, MET, MMP2, MMP9, PGR, PIM1, PTGS2, RORC, SRC, TYR 4.79053
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, TYR, XDH 4.72555
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, PIM1, SRC 4.71135
[BP] GO:0071310 cellular response to organic substance AKR1B1, APP, AR, AXL, CYP1A1, CYP1B1, FABP4, FLT3, GSK3B, IGF1R, KDR, MMP2, NR3C1, PTGS2, RORC, SRC 4.71135
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CYP1B1, GSK3B, IGF1R, MMP2, MMP9, NR3C1, PTGS2, RORC, SRC 4.68483
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, FLT3, GSK3B, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 4.25703
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APP, AR, CA2, CSNK2A1, CYP1A2, FABP3, FLT3, GSK3B, IGF1R, MMP2, NR3C1, PTGS2, SRC 4.25703
[BP] GO:0051716 cellular response to stimulus AKR1B1, APP, AR, AURKB, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP4, FLT3, GSK3B, IGF1R, KDR, MMP2, MMP9, NR3C1, PTGS2, PTPN1, RORC, SRC 4.1565
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, FABP4, FLT3, GSK3B, IDO1, KDR, MET, MMP12, MMP2, MMP9, PTGS2, PTPN1, SRC, XDH 4.14565
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 4.11718
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, TYR, XDH 4.07006
[BP] GO:0071407 cellular response to organic cyclic compound APP, AR, CYP1A1, CYP1B1, FLT3, NR3C1, PTGS2, RORC, SRC 3.99059
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, APP, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FLT3, GSK3B, HSD17B2, KDR, MMP9, PGR, PIM1, PTGS2, RORC, SRC, TYR 3.97673
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 3.97673
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 3.97673
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.89436
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.83859
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.79349
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, GSK3B, HSD17B2, IDO1, IGF1R, KDR, MMP12, MMP2, MMP9, NR3C1, PTGS2, PTPN1, RORC, SRC, TYR 3.77092
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GSK3B, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 3.65022
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, FABP3, FABP4, GSK3B, HCAR2, IDO1, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, XDH 3.64369
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MET, PTGS2 3.64253
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, GSK3B, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC 3.60484
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AXL, CYP1B1, FLT3, KDR, MET, PTGS2, PTPN1, SRC, XDH 3.59451
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GSK3B, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 3.58285
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, FABP3, FABP4, GSK3B, IDO1, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIM1, PTGS2, PTPN1, RORC, SRC, XDH 3.57667
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, FABP4, GSK3B, IGF1R, MET, MMP9, PIM1, PTGS2, PTPN1, SRC 3.53471
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, NR3C1, NR3C2, PGR, RORC, SRC 3.5236
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AXL, CYP19A1, CYP1A2, CYP1B1, FABP4, HSD17B2, IDO1, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS2, RORC, SRC, TYR 3.51631
[BP] GO:0001101 response to acid chemical AKR1B1, DHFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 3.351
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, IGF1R, KDR, MET, MMP9, PTGS2, PTPN1, SRC, XDH 3.34618
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.28417
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2 3.28083
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, DHFR, FABP4, GSK3B, IDO1, IGF1R, MET, MMP12, MMP2, PTGS2, PTPN1, SRC, XDH 3.16203
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 3.13765
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DHFR, FABP3, FLT3, GSK3B, IGF1R, MMP2, PTGS2, SRC, TYR 3.11538
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC 3.06487
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.06487
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, PTGS2, RORC, SRC 3.03191
[BP] GO:0009755 hormone-mediated signaling pathway AR, NR3C1, NR3C2, PGR, RORC, SRC 2.98586
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AR, AURKB, CSNK2A1, DHFR, FABP4, GSK3B, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PTGS2, PTPN1, RORC, SRC, XDH 2.98586
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.98586
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, APP, AURKB, AXL, CDC25B, CSNK2A1, DHFR, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, PTGS2, PTPN1, SRC, XDH 2.98586
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.9852
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HCAR2, HSD17B1, HSD17B2 2.92384
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.91398
[BP] GO:0030522 intracellular receptor signaling pathway AR, NR3C1, PGR, PIM1, RORC, SRC 2.91398
[BP] GO:0022414 reproductive process AKR1B1, APP, AR, AXL, CDC25B, CYP19A1, CYP1A1, HSD17B2, IDO1, MMP2, MMP9, PGR, PTGS2, SRC 2.91398
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 2.91076
[BP] GO:0009725 response to hormone AKR1B1, AR, CA2, CSNK2A1, CYP1A2, FABP3, FLT3, NR3C1, PTGS2, SRC 2.90569
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DHFR, FABP3, FLT3, GSK3B, IGF1R, MMP2, PTGS2, SRC, TYR 2.8854
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.87943
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, KDR, SRC, TYR 2.85053
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, IDO1 2.84506
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AR, AURKB, CDC25B, CSNK2A1, DHFR, FABP3, FLT3, GSK3B, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PTGS2, PTPN1, RORC, SRC, XDH 2.83479
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, KDR, NR3C1, PTGS2, SRC 2.83479
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.81244
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, AR, FLT3, GSK3B, IGF1R, MMP2, NR3C1, PTGS2, SRC 2.81244
[BP] GO:0006793 phosphorus metabolic process ACHE, APP, AURKB, AXL, CDC25B, CSNK2A1, DHFR, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, PTGS2, PTPN1, SRC, XDH 2.80506
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.80506
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.79031
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, IDO1, PIM1, PTGS2, TYR 2.7569
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1B1, DHFR, TYR 2.74505
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PTGS2 2.7342
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.63044
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.63044
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.63044
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.62389
[BP] GO:0043393 regulation of protein binding APP, AURKB, GSK3B, MET, MMP9, SRC 2.62389
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, PTGS2 2.60617
[BP] GO:0048869 cellular developmental process ACHE, APP, AR, AXL, CBR1, CDC25B, CYP1A1, FABP4, FLT3, FUT7, GSK3B, KDR, MET, MMP2, MMP9, PGR, PTGS2, RORC, SRC 2.59797
[BP] GO:0042493 response to drug AKR1B1, AXL, CYP1A1, CYP1B1, DHFR, FABP3, KDR, NR3C1, PTGS2, SRC 2.58949
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.56092
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.5507
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, AR, CDC25B, FABP3, FLT3, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.53732
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, AR, CDC25B, FABP3, FLT3, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.53732
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.53732
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DHFR, FLT3, FUT7, GSK3B, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TYR, XDH 2.53732
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AR, AURKB, CDC25B, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PTGS2, PTPN1, RORC, SRC, XDH 2.53732
[BP] GO:0060748 None AR, PGR 2.52362
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.52362
[BP] GO:0048545 response to steroid hormone AR, CA2, FLT3, NR3C1, PTGS2, SRC 2.50409
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.50409
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.50409
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, CA2, CYP1B1, HCAR2, IDO1, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SRC 2.45567
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.45319
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, AR, CDC25B, FLT3, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.4492
[BP] GO:0043436 oxoacid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, IDO1, PIM1, PTGS2, TYR 2.44366
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, CYP1B1, MMP9, PTGS2, SRC 2.41293
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GSK3B, IDO1, XDH 2.41293
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, HCAR2, KDR, PTGS2, SRC 2.41293
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PTGS2, PTPN1, SRC, XDH 2.41293
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.41008
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, CA2, CYP19A1, GSK3B, HCAR2, MMP12, PTGS2, SRC 2.40077
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, PTGS2 2.40073
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC 2.40073
[BP] GO:0006082 organic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, IDO1, PIM1, PTGS2, TYR 2.40072
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GSK3B, IGF1R, PTGS2, SRC 2.3896
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, IDO1 2.3896
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.37194
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AR, AURKB, CDC25B, FABP3, FLT3, GSK3B, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PTGS2, PTPN1, RORC, SRC, XDH 2.35982
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AR, AURKB, CDC25B, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PTGS2, PTPN1, RORC, SRC, XDH 2.33228
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, AR, CDC25B, FABP4, FLT3, IGF1R, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.33228
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, AR, CDC25B, FLT3, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.32683
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, GSK3B, HCAR2, MMP12, PTGS2, PTPN1, SRC 2.32322
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, AURKB, CDC25B, CSNK2A1, DHFR, FABP4, FLT3, GSK3B, IGF1R, MMP9, PTGS2, PTPN1, SRC, XDH 2.31888
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.31888
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.30853
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.30853
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.30731
[BP] GO:0071383 None AR, FLT3, NR3C1, SRC 2.30556
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CYP1A1, FLT3, MET, PIM1, SRC, TYR 2.303
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2 2.26727
[BP] GO:1904646 cellular response to amyloid-beta APP, GSK3B, IGF1R 2.26049
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, AR, FLT3, KDR, PTPN1, SRC, XDH 2.26049
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, NR3C1, PGR, SRC 2.23249
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.2181
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.21547
[BP] GO:1901655 None AKR1B1, AR, NR3C1, SRC 2.17984
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.17984
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, NR3C1, NR3C2, PGR, RORC 2.1793
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, IDO1 2.16582
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, IDO1, XDH 2.16147
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, FUT7, GSK3B, HCAR2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, TYR, XDH 2.16147
[BP] GO:0001816 cytokine production APP, FABP4, IDO1, PTGS2 2.15223
[BP] GO:1904645 response to amyloid-beta APP, GSK3B, IGF1R 2.15223
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, GSK3B, IGF1R, MMP2, PTGS2, SRC 2.13229
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, CYP1B1, FABP3, IDO1, PTGS2, XDH 2.10908
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.10268
[BP] GO:0010605 negative regulation of macromolecule metabolic process APP, AR, AURKB, CSNK2A1, DHFR, FABP4, GSK3B, IGF1R, KDR, MMP12, MMP9, NR3C1, PGR, PTGS2, PTPN1, RORC, SRC, XDH 2.08466
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.08466
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CYP1A1, PGR, PTGS2, SRC 2.08466
[BP] GO:0032496 response to lipopolysaccharide AXL, CYP1A1, CYP1A2, IDO1, PTGS2, SRC 2.08466
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, PTGS2 2.07158
[BP] GO:0021700 developmental maturation APP, AXL, CDC25B, MMP2, PGR 2.06995
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.06995
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, GSK3B, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 2.06342
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, AR, FLT3, IGF1R, KDR, PTPN1, SRC, XDH 2.06237
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, GSK3B, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 2.05464
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.05454
[BP] GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, MMP9, PTGS2, SRC 2.05311
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, AR, CDC25B, FABP4, FLT3, IGF1R, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.04925
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, GSK3B, PGR, RORC, SRC 2.04578
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, AR, CDC25B, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.02785
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3 2.02072
[BP] GO:1901654 None AKR1B1, AR, CSNK2A1, NR3C1, SRC 2.02017
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, AR, CDC25B, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.0003
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, CA1, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, HSD17B2, IDO1, KDR, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, SRC, TYR, XDH 2.86919
[CC] GO:0005829 cytosol AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, CA1, CA2, CA7, CBR1, CDC25B, CSNK2A1, DHFR, FABP3, FABP4, FLT3, GSK3B, HSD17B1, IDO1, NR3C1, NR3C2, PGR, PIM1, PTPN1, SRC, TYR, XDH 2.69385
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.01192
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP 1.81515
[CC] GO:0005783 None ADORA1, APP, CA4, CYP19A1, FLT3, KDR, PTGS2, PTPN1, XDH 1.41376
[MF] GO:0046914 transition metal ion binding ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, TYR, XDH 12.4348
[MF] GO:0043167 ion binding ACHE, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FABP4, FLT3, GSK3B, HSD17B1, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, RORC, SRC, TYR, XDH 8.45412
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FLT3, FUT7, GSK3B, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS2, PTPN1, SRC, TYR, XDH 8.22903
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 8.22903
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, HSD17B1, HSD17B2, IDO1, PTGS2, TYR, XDH 6.42159
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PTPN1, RORC 5.978
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.40325
[MF] GO:0043169 cation binding ACHE, ALOX5, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, RORC, TYR, XDH 4.76212
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, PTGS2, SRC 4.71135
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.70682
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, PTGS2, SRC 4.51577
[MF] GO:0005496 steroid binding AR, HSD17B1, NR3C1, NR3C2, PGR, RORC 4.38597
[MF] GO:0046872 metal ion binding ALOX5, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTGS2, PTPN1, RORC, TYR, XDH 4.38597
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.89504
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, HSD17B1, IDO1, PTGS2, SRC, XDH 3.87807
[MF] GO:0003707 steroid hormone receptor activity AR, NR3C1, NR3C2, PGR, RORC 3.82458
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.73618
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.72619
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, XDH 3.42028
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.29877
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NR3C1 3.16203
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TYR 3.13765
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.06781
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC 3.01239
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.98586
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.92384
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC 2.91963
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.85637
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7 2.83479
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, IDO1, XDH 2.80506
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 2.63044
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC 2.41252
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, RORC 2.34661
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PTPN1, SRC 2.33228
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX5, IDO1, PTGS2 2.303
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX5, IDO1, PTGS2 2.26049
[MF] GO:0008289 lipid binding AR, AXL, FABP3, FABP4, HSD17B1, NR3C1, NR3C2, PGR, RORC 2.21286
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC 2.17432
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.11325
[MF] GO:0051879 Hsp90 protein binding CSNK2A1, KDR, NR3C1 2.08466
[MF] GO:0004064 arylesterase activity CA1, CA2 2.01192


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 10.2693
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 9.8576
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.5527
Metabolic pathways_Homo sapiens_hsa01100 CBR1, AKR1B1, PTGS2, TYR, CYP19A1, DHFR, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH, IDO1 5.1921
Pathways in cancer_Homo sapiens_hsa05200 AR, GSK3B, FLT3, MMP1, MMP2, PTGS2, MMP9, MET, IGF1R 4.8649
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.6198
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1, IDO1 4.3326
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.8465
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2 4.4643
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.3326
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1 3.414
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 3.0357
Focal adhesion_Homo sapiens_hsa04510 GSK3B, SRC, KDR, MET, IGF1R 2.8732
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, PTGS2 2.4992
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.4232
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, PTGS2 2.4232
Prostate cancer_Homo sapiens_hsa05215 AR, GSK3B, IGF1R 2.0393
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.147
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.9834
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PGR, CDC25B, IGF1R 1.9834
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1 2.3118
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 1.9834
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, PTGS2 1.8658
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.7716
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.7924
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, KDR, MET, IGF1R 1.3974
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.2133
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.432
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.417
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.3501
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.3263
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, SRC 1.3263
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.1239
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3501
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1781
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.3627
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.1001
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, SRC 1.2042
Melanogenesis_Homo sapiens_hsa04916 GSK3B, TYR 1.1239
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, NR3C1 1.0786
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2717
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 1.0835
Insulin resistance_Homo sapiens_hsa04931 PTPN1, GSK3B 1.0835
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 1.1707
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, SRC 1.0625
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0625
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8844
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.0575
Measles_Homo sapiens_hsa05162 GSK3B, CSNK2A1 0.9867
Cell cycle_Homo sapiens_hsa04110 GSK3B, CDC25B 1.0398
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 1.0289
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, GSK3B 0.9867
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.9722
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, IGF1R 0.9867
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B, CSNK2A1 0.9867
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9867
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2 0.9187
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.8986
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0393
Alzheimer's disease_Homo sapiens_hsa05010 GSK3B, APP 0.8986
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7924
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, CSNK2A1 0.8099
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, SRC 0.8431
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1 0.815
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8623
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.3208
HTLV-I infection_Homo sapiens_hsa05166 GSK3B 0.3206
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.3737
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3845
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4257
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4157
Influenza A_Homo sapiens_hsa05164 GSK3B 0.4257
Tuberculosis_Homo sapiens_hsa05152 SRC 0.4254
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.4564
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B 0.4653
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B 0.4643
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.5077
Platelet activation_Homo sapiens_hsa04611 SRC 0.5245
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B 0.5268
Hepatitis C_Homo sapiens_hsa05160 GSK3B 0.5077
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.5223
Dopaminergic synapse_Homo sapiens_hsa04728 GSK3B 0.5114
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.5482
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.569
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.5291
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5797
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5835
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B 0.569
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.5722
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5916
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5916
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5835
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5916
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5916
Gap junction_Homo sapiens_hsa04540 SRC 0.5916
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5835
Small cell lung cancer_Homo sapiens_hsa05222 PTGS2 0.5916
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5916
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B 0.6379
Peroxisome_Homo sapiens_hsa04146 XDH 0.5965
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6371
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6379
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6602
Glioma_Homo sapiens_hsa05214 IGF1R 0.6602
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6615
Bile secretion_Homo sapiens_hsa04976 CA2 0.6394
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.659
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6602
Colorectal cancer_Homo sapiens_hsa05210 GSK3B 0.6602
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.6459
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6602
Shigellosis_Homo sapiens_hsa05131 SRC 0.6602
Endometrial cancer_Homo sapiens_hsa05213 GSK3B 0.7089
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.6914
Malaria_Homo sapiens_hsa05144 MET 0.7222
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.7194
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7423
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 NR3C2 0.8047
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.8321
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.8321
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8645
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8798
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8993
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8719
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8986
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.187
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 0.9867
Folate biosynthesis_Homo sapiens_hsa00790 DHFR 1.0625


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)